Paul R Massey, David M Wang, Fadi Murad, Patrick Mulvaney, Kevin Moore, Jean-Phillip Okhovat, Eleanor Russell-Goldman, William M Lin, Adriano Piris, Shyamala C Huilgol, Emily S Ruiz, Chrysalyne D Schmults
IMPORTANCE: Perineural invasion (PNI) is an adverse risk feature in cutaneous squamous cell carcinoma (CSCC) that affects patient prognosis and disease management. However, research comparing different PNI patterns on patient outcomes is limited. OBJECTIVE: To compare 4 assessments of PNI in CSCC, their associations with poor outcomes, and implications for their inclusion in the Brigham and Women's Hospital (BWH) staging system. DESIGN, SETTING, AND PARTICIPANTS: This retrospective cohort study was performed at a single tertiary care institution and compared 4 PNI assessments: nerve caliber, number of involved nerves per section, PNI maximal depth, and PNI location with respect to tumor...
October 18, 2023: JAMA Dermatology