keyword
https://read.qxmd.com/read/38226329/vulnerability-and-colorectal-screening-during-the-pandemic
#21
JOURNAL ARTICLE
Roopa S Bhat, Suzanne Brodney, Yuchiao Chang, Meghan Rieu-Werden, Folasade P May, Jennifer S Haas
OBJECTIVE: Disparities in colorectal cancer (CRC) screening prevalence across United States neighborhoods may reflect social inequities that create barriers to accessing and completing preventive health services. Our objective was to identify whether neighborhood social vulnerability was associated with a change in CRC screening prevalence in Boston neighborhoods during the COVID-19 pandemic. METHODS: Adults ages 50-74 years due for CRC screening who received primary care at one of 35 primary care practices affiliated with Massachusetts General Hospital or Brigham and Women's Hospital (Boston, MA), 3/1/2020 to 3/1/2022...
January 2024: Preventive Medicine Reports
https://read.qxmd.com/read/38197147/footprint-of-emergency-medicine-physicians-in-disaster-medicine-publications-a-bibliometric-analysis
#22
JOURNAL ARTICLE
Nurcan Biçakçi, Sercan Biçakçi
INTRODUCTION: Investigating the developments in the ever-growing field of disaster medicine and revealing the scientific trends will make an important contribution to researchers in related fields. This study aims to identify the contributions of emergency medicine physicians (EMPs) and trends in disaster medicine publications. METHODS: The expressions "disaster medicine" or "disaster*" and "medicine*" were searched in the Web of Science (WoS) database. Research and review papers produced by EMPs from 2001 through 2021 were included in the study...
January 10, 2024: Prehospital and Disaster Medicine
https://read.qxmd.com/read/38195100/oral-antibiotics-for-treatment-of-gram-negative-bacteremia-in-solid-organ-transplant-recipients-a-propensity-score-weighted-retrospective-observational-study
#23
JOURNAL ARTICLE
Eliezer Zachary Nussbaum, Sophia Koo, Camille N Kotton
BACKGROUND: We assessed the safety and efficacy of oral antibiotic step-down therapy for uncomplicated gram-negative blood stream infections in solid organ transplant recipients. METHODS: We identified all solid organ transplant recipients within the Massachusetts General and Brigham and Women's Hospital systems from 2016-2021 with uncomplicated gram-negative bacteremia involving an organism susceptible to an acceptably bioavailable oral antibiotic agent. Using inverse probability of treatment-weighted models based on propensity scores adjusting for potential clinical confounders, we compared outcomes of those transitioned to oral antibiotics vs those who continued IV therapy for the duration of treatment...
January 9, 2024: Clinical Infectious Diseases
https://read.qxmd.com/read/38190313/the-european-heart-journal-s-top-contributing-institutions-the-heart-and-vascular-center-at-brigham-and-women-s-hospital
#24
JOURNAL ARTICLE
Judith Ozkan
No abstract text is available yet for this article.
January 8, 2024: European Heart Journal
https://read.qxmd.com/read/38168253/self-supervised-artificial-intelligence-predicts-recurrence-metastasis-and-disease-specific-death-from-primary-cutaneous-squamous-cell-carcinoma-at-diagnosis
#25
John Carucci, Nicolas Coudray, Michelle Juarez, Maressa Criscito, Adalberto Quiros, Reason Wilken, Stephanie Jackson Cullison, Mary Stevenson, Nicole Doudican, Ke Yuan, Jamie Aquino, Daniel Klufas, Jeffrey North, Siegrid Yu, Fadi Murad, Emily Ruiz, Chrysalyne Schmults, Aristotelis Tsirigos
Primary cutaneous squamous cell carcinoma (cSCC) is responsible for ~ 10,000 deaths annually in the United States. Stratification of risk of poor outcome (PO) including recurrence, metastasis and disease specific death (DSD) at initial biopsy would significantly impact clinical decision-making during the initial post operative period where intervention has been shown to be most effective.. In this multi-institutional study, we developed a state-of-the-art self-supervised deep-learning approach with interpretability power and demonstrated its ability to predict poor outcomes of cSCCs at the time of initial biopsy...
December 13, 2023: Research Square
https://read.qxmd.com/read/38159106/automation-of-functional-mobility-assessments-at-home-using-a-multimodal-sensor-system-integrating-inertial-measurement-units-and-computer-vision-imu-vision
#26
JOURNAL ARTICLE
Johanna Spangler, Marc Mitjans, Ashley Collimore, Aysha Gomes-Pires, David M Levine, Roberto Tron, Lou Awad
OBJECTIVE: Functional movement assessments are routinely used to evaluate and track changes in mobility. The objective of this study was to evaluate a multimodal movement monitoring system developed for autonomous, home-based, functional movement assessment. METHODS: Fifty frail and pre-frail adults were recruited from the Brigham and Women's Hospital at Home program to evaluate the feasibility and accuracy of applying the multimodal movement monitoring system to autonomously recognize and score functional activities collected in the home...
December 30, 2023: Physical Therapy
https://read.qxmd.com/read/38152028/an-update-on-long-term-mental-health-in-eight-face-transplant-recipients-a-single-center-experience
#27
JOURNAL ARTICLE
Lioba Huelsboemer, Viola A Stögner, Helia Hosseini, Sacha Hauc, Sam Boroumand, Neil Parikh, Alexa Blood, Vikram Mookerjee, Martin Kauke-Navarro, Marie-Christine Nizzi, Bohdan Pomahac
OBJECTIVE: Face transplantation is a groundbreaking and complex surgical intervention offering profound physical and psychological benefits to patients with severe facial disfigurements. This report provides an update on the long-term psychosocial outcome of eight face transplant recipients. METHOD: All transplant recipients were initially transplanted at Brigham and Women´s Hospital (Boston, USA) between 2011 and 2020 and are seen as outpatient patients at Yale New Haven Hospital (New Haven, USA)...
December 28, 2023: International Journal of Psychiatry in Medicine
https://read.qxmd.com/read/38151738/validation-of-a-questionnaire-assessing-smell-loss-in-an-international-aspirin-exacerbated-respiratory-disease-population
#28
JOURNAL ARTICLE
Marie Lundberg, Rie Maurer, Raffi Tchekmedyian, Jyotsna Mullur, Jillian C Bensko, Kathleen M Buchheit, Tanya M Laidlaw
Background: Olfactory dysfunction (OD) and smell loss affects aspects of patients' everyday life and lowers their quality of life. OD questionnaires are considered one of the core-outcome measures in chronic rhinosinusitis, but many existing smell loss questionnaires contained pandemic-prohibitive questions on social gatherings or restaurant visits, were too culture specific or gender specific, or were overly long and cumbersome. Objective: We aimed to develop a new brief questionnaire to assess the impact and consequences of smell loss and its burden on daily life...
January 1, 2024: Allergy and Asthma Proceedings:
https://read.qxmd.com/read/38135330/implementation-of-a-scalable-online-weight-management-programme-in-clinical-settings-protocol-for-the-props-2-0-programme-partnerships-for-reducing-overweight-and-obesity-with-patient-centered-strategies-2-0
#29
JOURNAL ARTICLE
JoAnn Cho, Sarah H Noonan, Richard Fay, Caroline M Apovian, Ashley C McCarthy, Alexander J Blood, Lipika Samal, Naomi Fisher, John E Orav, Jorge Plutzky, Jason P Block, David Westfall Bates, Ronen Rozenblum, Michela Tucci, Marian McPartlin, Willam J Gordon, Katherine D McManus, Cheryl Morrison-Deutsch, Benjamin M Scirica, Heather J Baer
INTRODUCTION: There is an urgent need for scalable strategies for treating overweight and obesity in clinical settings. PROPS 2.0 (Partnerships for Reducing Overweight and Obesity with Patient-Centered Strategies 2.0) aims to adapt and implement the combined intervention from the PROPS Study at scale, in a diverse cross-section of patients and providers. METHODS AND ANALYSIS: We are implementing PROPS 2.0 across a variety of clinics at Brigham and Women's Hospital, targeting enrolment of 5000 patients...
December 21, 2023: BMJ Open
https://read.qxmd.com/read/37991774/evaluation-of-dermsat-7-for-assessing-treatment-satisfaction-in-patients-with-acne
#30
JOURNAL ARTICLE
Ali Shields, April W Armstrong, Manraj N Kaur, Alison Layton, Diane Thiboutot, Jerry Tan, John S Barbieri
IMPORTANCE: Treatment satisfaction is important to achieving therapeutic success in patients with inflammatory dermatological diseases, such as acne. OBJECTIVE: To evaluate the structural validity, internal consistency, and construct validity of the DermSat-7, a questionnaire-based measure of treatment satisfaction, in patients with acne seen in routine clinical practice. DESIGN, SETTING, AND PARTICIPANTS: This cross-sectional study included adults with acne who were fluent in English and treated at an outpatient clinic at Brigham and Women's Hospital between July 2022 and May 2023...
November 22, 2023: JAMA Dermatology
https://read.qxmd.com/read/37991757/system-level-factors-and-time-spent-on-electronic-health-records-by-primary-care-physicians
#31
JOURNAL ARTICLE
Lisa S Rotenstein, A Jay Holmgren, Daniel M Horn, Stuart Lipsitz, Russell Phillips, Richard Gitomer, David W Bates
IMPORTANCE: Primary care physicians (PCPs) spend the most time on the electronic health record (EHR) of any specialty. Thus, it is critical to understand what factors contribute to varying levels of PCP time spent on EHRs. OBJECTIVE: To characterize variation in EHR time across PCPs and primary care clinics, and to describe how specific PCP, patient panel, clinic, and team collaboration factors are associated with PCPs' time spent on EHRs. DESIGN, SETTING, AND PARTICIPANTS: This cross-sectional study included 307 PCPs practicing across 31 primary care clinics at Massachusetts General Hospital and Brigham and Women's Hospital during 2021...
November 1, 2023: JAMA Network Open
https://read.qxmd.com/read/37962141/performance-of-staging-systems-for-non-head-and-neck-cutaneous-squamous-cell-carcinoma
#32
JOURNAL ARTICLE
Ricardo Guerra, Kathryn T Shahwan, Melica Nikahd, Madison Hyer, David R Carr
BACKGROUND: The performance of staging systems in non-head and neck cutaneous squamous cell carcinomas has not been well established. OBJECTIVE: To evaluate the performance of the American Joint Committee on Cancer 8th Edition and Brigham and Women's Hospital staging systems in non-head and neck squamous cell carcinomas. MATERIALS AND METHODS: Eligible tumors were identified and staged from an existing retrospective database. Cumulative incidence function curves of any poor outcome were generated...
November 2, 2023: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://read.qxmd.com/read/37954812/40-gene-expression-profile-representative-of-metastatic-risk-of-squamous-cell-carcinoma-in-a-mohs-surgical-patient
#33
Kristin N Slater, Elizabeth Ryder, Carlos Gomez-Meade
This case study examines using a 40-gene expression profile (40-GEP) as an independent predictor of metastatic risk in a 74-year-old male with cutaneous squamous cell carcinoma on the scalp. The patient's previous medical history included melanoma and non-melanoma skin cancers. While conventional staging methods, such as the American Joint Committee on Cancer 8th edition (AJCC8) and Brigham and Women's Hospital (BWH) staging, indicated a higher metastatic risk, the 40-GEP testing classified the patient as low risk (Class 1 result) for metastasis within three years...
October 2023: Curēus
https://read.qxmd.com/read/37943268/seasonal-patterns-in-tetracycline-associated-hyperpigmentation-among-patients-with-acne-vulgaris
#34
JOURNAL ARTICLE
Katherine Young, Angel D Pagan, Jaewon Yoon, Ethiopia Getachew, Bonnie Leung, Nga Nguyen, Yevgeniy R Semenov, Arash Mostaghimi, Nicholas Theodosakis
BACKGROUND: Oral tetracyclines (TCNs) are commonly prescribed for acne, but they have been shown to increase the risk of hyperpigmentation, particularly in the setting of sun exposure. OBJECTIVE: We evaluated seasonal trends in TCN-associated hyperpigmentation incidence in addition to Google search trends for hyperpigmentation-related terms. METHODS: We performed a retrospective review of acne patients seen at Massachusetts General Brigham and Women’s Hospital between 1992 and 2022...
November 1, 2023: Journal of Drugs in Dermatology: JDD
https://read.qxmd.com/read/37910651/outcomes-of-squamous-cell-carcinoma-of-the-lip-treated-with-mohs-micrographic-surgery-a-retrospective-cohort-study
#35
JOURNAL ARTICLE
Umer Nadir, Kim Le, Kevin Shi, Divya Srivastava, Rajiv I Nijhawan
BACKGROUND: Cutaneous squamous cell carcinomas (cSCCs) of the lip have been reported to be at higher risk for poorer post-treatment outcomes. OBJECTIVE: To examine outcomes of patients with SCC of the lip treated with Mohs micrographic surgery (MMS) and identify factors for recurrence. MATERIALS AND METHODS: This retrospective review of a single tertiary referral center's Mohs case logs from 2010 to 2019 identified cases of lip SCC. Clinicopathologic characteristics and outcomes (local recurrence [LR], metastasis, and disease-specific death) were reviewed...
November 1, 2023: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://read.qxmd.com/read/37910643/evaluating-predictors-of-patient-satisfaction-with-facial-appearance-after-mohs-micrographic-surgery-using-the-face-q
#36
JOURNAL ARTICLE
William C Lau, Kevin Moore, Abigail Waldman
BACKGROUND: Although patient satisfaction with reconstructive outcomes after facial skin cancer resection is an important consideration in Mohs surgery, there is limited information evaluating this concern using validated patient-reported outcome tools. OBJECTIVE: To characterize predictors that may be associated with increased postoperative patient satisfaction with facial appearance after Mohs surgery using the FACE-Q/Skin Cancer survey, a patient-reported outcome tool that has been validated in various studies...
October 30, 2023: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://read.qxmd.com/read/37898791/functional-principal-component-analysis-and-sparse-group-lasso-to-identify-associations-between-biomarker-trajectories-and-mortality-among-hospitalized-sars-cov-2-infected-individuals
#37
JOURNAL ARTICLE
Tingyi Cao, Harrison T Reeder, Andrea S Foulkes
BACKGROUND: A substantial body of clinical research involving individuals infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has evaluated the association between in-hospital biomarkers and severe SARS-CoV-2 outcomes, including intubation and death. However, most existing studies considered each of multiple biomarkers independently and focused analysis on baseline or peak values. METHODS: We propose a two-stage analytic strategy combining functional principal component analysis (FPCA) and sparse-group LASSO (SGL) to characterize associations between biomarkers and 30-day mortality rates...
October 28, 2023: BMC Medical Research Methodology
https://read.qxmd.com/read/37873025/does-the-association-between-psychosocial-factors-and-opioid-use-after-elective-spine-surgery-differ-by-sex-in-older-adults
#38
JOURNAL ARTICLE
Linda S Aglio, Elisabetta Mezzalira, Sarah M Corey, Kara G Fields, Blake M Hauser, Maria J Susano, Deborah J Culley, Kristin L Schreiber, Nicole J Kelly-Aglio, Megan E Patton, Rania A Mekary, Robert R Edwards
PURPOSE: Psychosocial disorders have been linked to chronic postoperative opioid use and the development of postoperative pain. The potential interaction between sex and psychosocial factors with respect to opioid use after elective spine surgery in the elderly has not yet been evaluated. Our aim was to assess whether any observed association of anxiety or depression indicators with opioid consumption in the first 72 hours after elective spine surgery varies by sex in adults ≥65 years...
2023: Journal of Pain Research
https://read.qxmd.com/read/37851425/extensive-perineural-invasion-vs-nerve-caliber-to-assess-cutaneous-squamous-cell-carcinoma-prognosis
#39
JOURNAL ARTICLE
Paul R Massey, David M Wang, Fadi Murad, Patrick Mulvaney, Kevin Moore, Jean-Phillip Okhovat, Eleanor Russell-Goldman, William M Lin, Adriano Piris, Shyamala C Huilgol, Emily S Ruiz, Chrysalyne D Schmults
IMPORTANCE: Perineural invasion (PNI) is an adverse risk feature in cutaneous squamous cell carcinoma (CSCC) that affects patient prognosis and disease management. However, research comparing different PNI patterns on patient outcomes is limited. OBJECTIVE: To compare 4 assessments of PNI in CSCC, their associations with poor outcomes, and implications for their inclusion in the Brigham and Women's Hospital (BWH) staging system. DESIGN, SETTING, AND PARTICIPANTS: This retrospective cohort study was performed at a single tertiary care institution and compared 4 PNI assessments: nerve caliber, number of involved nerves per section, PNI maximal depth, and PNI location with respect to tumor...
October 18, 2023: JAMA Dermatology
https://read.qxmd.com/read/37813595/increasing-neurofilament-and-glial-fibrillary-acidic-protein-after-treatment-discontinuation-predicts-multiple-sclerosis-disease-activity
#40
JOURNAL ARTICLE
Gauruv Bose, Brian C Healy, Shrishti Saxena, Fermisk Saleh, Bonnie I Glanz, Rohit Bakshi, Howard L Weiner, Tanuja Chitnis
BACKGROUND AND OBJECTIVES: Stable patients with multiple sclerosis (MS) may discontinue treatment, but the risk of disease activity is unknown. Serum neurofilament light chain (sNfL) and serum glial fibrillary acidic protein (sGFAP) are biomarkers of subclinical disease activity and may help risk stratification. In this study, sNfL and sGFAP levels in stable patients were evaluated before and after treatment discontinuation to determine association with disease activity. METHODS: This observational study included patients enrolled in the Comprehensive Longitudinal Investigation in MS at the Brigham and Women's Hospital who discontinued treatment after >2 years disease activity-free...
November 2023: Neurology® Neuroimmunology & Neuroinflammation
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