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JOURNAL ARTICLE
Shibo Chen, Qingquan Liu, Jianjun Yan
Shift work has been found to disrupt the circadian system, leading to negative health effects. The objective of this study was to assess the progress and frontiers in research on the health-related influence of shift work. The study analyzed 3,696 data points from Web of Science, using the bibliometric software CiteSpace to visualize and analyze the field. The results showed a steady increase in annual publications, particularly in the last 5 years, with a rapid increase in publications from China. The United States contributed the most to the number of publications and worldwide collaborations...
April 8, 2024: Chronobiology International
#2
JOURNAL ARTICLE
Cassie B MacRae, Kristina C Grieco, Isaac H Solomon
Medical autopsies have decreased in frequency due in part to advances in radiological techniques and increased availability of molecular and other ancillary testing. However, premortem diagnosis of CNS disease remains challenging; while ∼90% of brain tumor biopsies are diagnostic, only 20%-70% of biopsies for presumed nonneoplastic disease result in a specific diagnosis. The added benefits of performing an autopsy following surgical brain biopsy are not well defined. A retrospective analysis was performed of patients who underwent brain biopsy and autopsy at Brigham and Women's Hospital from 2003 to 2022...
March 19, 2024: Journal of Neuropathology and Experimental Neurology
#3
JOURNAL ARTICLE
Andrea Gilmore, Brianna Castillo, Nicholas Golda, Kara Braudis, Emily Smith
BACKGROUND: Mohs micrographic surgery (MMS) is used for the treatment of high-risk cutaneous squamous cell carcinoma (cSCC). MMS examines the surgical margins in real time and does not commonly examine the central component of the tumor. OBJECTIVE: To determine if debulk specimens provide additional details relevant to tumor staging not gained from routine MMS. METHODS: A retrospective chart review of debulk specimens taken during MMS for cSCC was performed...
June 2024: JAAD international
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JOURNAL ARTICLE
Christopher Gilligan, Willem Volschenk, Marc Russo, Matthew Green, Christopher Gilmore, Vivek Mehta, Kristiaan Deckers, Kris De Smedt, Usman Latif, Dawood Sayed, Peter Georgius, Jonathan Gentile, Bruce Mitchell, Meredith Langhorst, Frank Huygen, Ganesan Baranidharan, Vikas Patel, Eugene Mironer, Edgar Ross, Alexios Carayannopoulos, Salim Hayek, Ashish Gulve, Jean-Pierre Van Buyten, Antoine Tohmeh, Jeffrey Fischgrund, Shivanand Lad, Farshad Ahadian, Timothy Deer, William Klemme, Richard Rauck, James Rathmell, Greg Maislin, Jan Pieter Heemels, Sam Eldabe
BACKGROUND: Adults with refractory, mechanical chronic low back pain associated with impaired neuromuscular control of the lumbar multifidus muscle have few treatment options that provide long-term clinical benefit. This study hypothesized that restorative neurostimulation, a rehabilitative treatment that activates the lumbar multifidus muscles to overcome underlying dysfunction, is safe and provides relevant and durable clinical benefit to patients with this specific etiology. MATERIALS AND METHODS: In this prospective five-year longitudinal follow-up of the ReActiv8-B pivotal trial, participants (N = 204) had activity-limiting, moderate-to-severe, refractory, mechanical chronic low back pain, a positive prone instability test result indicating impaired multifidus muscle control, and no indications for spine surgery...
March 11, 2024: Neuromodulation: Journal of the International Neuromodulation Society
#5
JOURNAL ARTICLE
Shahin A Saberi, Sydney Moore, Sienna Li, Rory Vu Mather, Mary B Daniels, Amrita Shahani, Antje Barreveld, Todd Griswold, Patrick McGuire, Hilary S Connery
BACKGROUND: Naloxone is an effective and safe opioid reversal medication now approved by the U.S. Food and Drug Administration (FDA) for use with or without a prescription. Despite this, naloxone dissemination lags at a time when U.S. opioid-related mortality expands. The authors proposed distributing naloxone to all U.S. medical students using established statewide standing prescription orders for naloxone, eliminating the financial burden of over-the-counter costs on students and streamlining workflow for the pharmacy...
March 6, 2024: BMC Medical Education
#6
JOURNAL ARTICLE
Dimitrios Rallis, Aimilia Eirini Papathanasiou, Helen Christou
CONTEXT: In utero exposure to maternal obesity or diabetes is considered a pro-inflammatory state. OBJECTIVE: To evaluate whether cord blood proprotein convertase subtilisin/kexin-type 9 (PCSK9), which is regulated by inflammation and metabolic derangements, is elevated in neonates born to overweight, obese, or diabetic mothers. METHODS: A retrospective study in full-term neonates born between 2010 and 2023, at Brigham and Women's Hospital...
February 19, 2024: Journal of the Endocrine Society
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JOURNAL ARTICLE
Martin Kauke-Navarro, Sam Sadigh, Catherine A A Lee, Adriana C Panayi, Leonard Knoedler, Samuel Knoedler, Viola Stoegner, Lioba Huelsboemer, Azzi Jamil, Christine Ko, Christine G Lian, George F Murphy, Bohdan Pomahac
BACKGROUND: Apart from the skin, little is known about the immunological processes in deeper tissues, which are typically not accessible to biopsy and inspection, of vascularized composite allografts (VCAs). Face transplant patients develop prominent adenopathy shortly after transplantation that resolves over time. The mechanisms underlying this process are not understood. MATERIALS AND METHODS: A retrospective cohort study was conducted on 9 patients who underwent 10 facial VCAs at the Brigham and Women's Hospital, Boston, MA, between April 2009 and July 2019...
February 7, 2024: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
#8
JOURNAL ARTICLE
Ashley Wysong, Ally-Khan Somani, Sherrif F Ibrahim, Javier Cañueto, Alison L Fitzgerald, Jennifer J Siegel, Anesh Prasai, Matthew S Goldberg, Aaron S Farberg, Christie Regula, Anna Bar, Julia Kasprzak, David G Brodland, Shlomo A Koyfman, Sarah T Arron
INTRODUCTION: The validated 40-gene expression profile (40-GEP) test independently stratifies risk of regional or distant metastasis for cutaneous squamous cell carcinoma (cSCC) tumors with high-risk clinicopathologic features. This study evaluated the stratification of risk by the 40-GEP test in a large cohort of tumors with one or more high-risk factors and in clinically relevant subgroups, including tumors within National Comprehensive Cancer Network (NCCN) high- and very-high-risk groups, lower-stage BWH T1 and T2a tumors, and patients > 65 years old...
March 1, 2024: Dermatology and Therapy
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JOURNAL ARTICLE
Laura E Smith, Trancy Escobar, Andrea McCabe, James Grafton, Margaret Higgins, Melissa Littlefield, Soumi Ray, Peggy Leung, Alexander Fiksdal, Roaa M Khinkar, Reg B Wilcox, Carolyn Yuse, Katie Fillipon, Thomas Walsh, Charles A Morris, Shelly Anderson, Madelyn Pearson, Mallika L Mendu
PURPOSE/OBJECTIVES: The onset of the coronavirus disease 2019 pandemic increased the demand for inpatient services and led to widespread staffing shortages in the acute and post-acute setting, contributing to delayed inpatient throughput and leading to capacity crises. Novel strategies are needed to facilitate the efficient progression of hospitalized patients when medically ready for lower levels of care. The authors have developed a foundational strategic framework for patient progression to ensure capture of patient progression data, enhance efficiency, and optimal utilization of post-acute resources in increasingly complex and resource-constrained acute and post-acute environments...
March 1, 2024: Professional Case Management
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JOURNAL ARTICLE
Lauren E Merz, Miriam A Osei, Aliza Green, Charlotte M Story, Kelly M Schuering, Maureen Okam Achebe
PROBLEM: Approximately 100,000 individuals in the United States have sickle cell disease (SCD). These individuals face multiple barriers to equitable care. At Brigham and Women's Hospital, existing health inequities for these patients were compounded by admitting, rounding, and team structures that assigned patients with SCD to multiple medicine teams with a hematologist attending, leading to delays in patient care and gaps in residents' hematology knowledge. APPROACH: A hematology-general medicine hybrid team was created in September 2021 to enhance trainee knowledge, skill, and confidence in managing hematology conditions and improve the quality of care delivered to individuals with SCD...
February 27, 2024: Academic Medicine
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JOURNAL ARTICLE
Joyce H Lee, Diana D Shi, Kee-Young Shin, Elizabeth Buckley, Lauren Gunasti, Emily Hall, Eileen Mann, Beverly Spicer, Yu-Hui Chen, Lubna Hammoudeh, Victoria Brennan, Mai Anh Huynh, Alexander Spektor, Monica S Krishnan, Tracy A Balboni, Lauren M Hertan
PURPOSE: Stereotactic body radiation therapy (SBRT) is a promising treatment for oligometastatic disease in bone because of its delivery of high dose to target tissue and minimal dose to surrounding tissue. The purpose of this study is to assess the efficacy and toxicity of this treatment in patients with previously unirradiated oligometastatic bony disease. METHODS AND MATERIALS: In this prospective phase II trial, patients with oligometastatic bone disease, defined as ≤3 active sites of disease, were treated with SBRT at Brigham and Women's Hospital/Dana Farber Cancer Center and Beth Israel Deaconess Medical Center between December 2016 and May 2019...
April 2024: Advances in Radiation Oncology
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JOURNAL ARTICLE
Nikos Papadimitriou, Conghui Qu, Tabitha A Harrison, Alaina M Bever, Richard M Martin, Konstantinos K Tsilidis, Polly A Newcomb, Stephen N Thibodeau, Christina C Newton, Caroline Y Um, Mireia Obón-Santacana, Victor Moreno, Hermann Brenner, Marko Mandic, Jenny Chang-Claude, Michael Hoffmeister, Andrew J Pellatt, Robert E Schoen, Sophia Harlid, Shuji Ogino, Tomotaka Ugai, Daniel D Buchanan, Brigid M Lynch, Stephen B Gruber, Yin Cao, Li Hsu, Jeroen R Huyghe, Yi Lin, Robert S Steinfelder, Wei Sun, Bethany Van Guelpen, Syed H Zaidi, Amanda E Toland, Sonja I Berndt, Wen-Yi Huang, Elom K Aglago, David A Drew, Amy J French, Peter Georgeson, Marios Giannakis, Meredith Hullar, Johnathan A Nowak, Claire E Thomas, Loic Le Marchand, Iona Cheng, Steven Gallinger, Mark A Jenkins, Marc J Gunter, Peter T Campbell, Ulrike Peters, Mingyang Song, Amanda I Phipps, Neil Murphy
BACKGROUND: Obesity has been positively associated with most molecular subtypes of colorectal cancer (CRC); however, the magnitude and the causality of these associations is uncertain. METHODS: We used Mendelian randomization (MR) to examine potential causal relationships between body size traits (body mass index [BMI], waist circumference, and body fat percentage) with risks of Jass classification types and individual subtypes of CRC (microsatellite instability [MSI] status, CpG island methylator phenotype [CIMP] status, BRAF and KRAS mutations)...
February 12, 2024: EBioMedicine
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JOURNAL ARTICLE
Saksham Gupta, Samantha E Hoffman, Neel H Mehta, Blake Hauser, Marcelle Altshuler, Joshua D Bernstock, Timothy R Smith, Omar Arnaout, Edward R Laws
PURPOSE: Pituitary adenomas are the most common tumor of the pituitary gland and comprise nearly 15% of all intracranial masses. These tumors are stratified into functional or silent categories based on their pattern of hormone expression and secretion. Preliminary evidence supports differential clinical outcomes between some functional pituitary adenoma (FPA) subtypes and silent pituitary adenoma (SPA) subtypes. METHODS: We collected and analyzed the medical records of all patients undergoing resection of SPAs or FPAs from a single high-volume neurosurgeon between 2007 and 2018 at Brigham and Women's Hospital...
February 12, 2024: Pituitary
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JOURNAL ARTICLE
Negar Molazadeh, Philippe A Bilodeau, Rebecca Salky, Gauruv Bose, Itay Lotan, Gabriela Romanow, Monique R Anderson, Marcelo Matiello, Tanuja Chitnis, Michael Levy
BACKGROUND: Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) is an autoimmune disease that can present as a monophasic or relapsing disease course. Here, we investigate the predictors of developing relapsing disease with a focus on the index event. METHODS: MOGAD patients followed at Massachusetts General Hospital and Brigham and Women's Hospital were included. Data on demographic, clinical, and laboratory features were collected. Time-to-event survival analysis was performed using a Cox proportional hazards model...
January 30, 2024: Journal of the Neurological Sciences
#15
JOURNAL ARTICLE
Abhijit Bhattaru, Chaitanya Rojulpote, Mahesh Vidula, Jeffrey Duda, Matthew T Maclean, Sophia Swago, Elizabeth Thompson, James Gee, Janice Pieretti, Brian Drachman, Adam Cohen, Sharmila Dorbala, Paco E Bravo, Walter R Witschey
PURPOSE: We employed deep learning to automatically detect myocardial bone-seeking uptake, as a marker of transthyretin cardiac amyloid cardiomyopathy (ATTR-CM) in patients undergoing 99mTc-pyrophosphate (PYP) or hydroxydiphosphonate (HDP) single-photon emission computed tomography (SPECT)/computed tomography (CT). METHODS: We identified a primary cohort of 77 subjects at Brigham and Women's Hospital and a validation cohort of 93 consecutive patients imaged at the University of Pennsylvania who underwent SPECT/CT with PYP and HDP respectively for evaluation of ATTR-CM...
January 31, 2024: Journal of Nuclear Cardiology
#16
JOURNAL ARTICLE
Peter Novak, David M Systrom, Sadie P Marciano, Alexandra Knief, Donna Felsenstein, Matthew P Giannetti, Matthew J Hamilton, Jennifer Nicoloro-SantaBarbara, Tara V Saco, Mariana Castells, Khosro Farhad, David M Pilgrim, William J Mullally
Autonomic symptom questionnaires are frequently used to assess dysautonomia. It is unknown whether subjective dysautonomia obtained from autonomic questionnaires correlates with objective dysautonomia measured by quantitative autonomic testing. The objective of our study was to determine correlations between subjective and objective measures of dysautonomia. This was a retrospective cross-sectional study conducted at Brigham and Women's Faulkner Hospital Autonomic Laboratory between 2017 and 2023 evaluating the patients who completed autonomic testing...
January 30, 2024: Scientific Reports
#17
JOURNAL ARTICLE
Delaney M Corcoran, Mary P Kovacevic, Heather Dell'Orfano, Katelyn W Sylvester, Jean M Connors
INTRODUCTION: Brigham and Women's Hospital (BWH) historically used titratable weight-based heparin nomograms with as needed boluses managed by extracorporeal membrane oxygenation (ECMO) specialists to achieve a pre-determined goal activated partial thromboplastin time (aPTT). Due to concern amongst providers that as needed boluses may lead to supratherapeutic aPTT's and subsequent bleeding, new nomograms without as needed boluses were implemented. The purpose of this retrospective observational analysis is to provide a comparison in safety and efficacy between the heparin nomograms with as needed boluses and the new nomograms without boluses...
January 30, 2024: Critical Pathways in Cardiology
#18
Julia F Charles, Alan O Malabanan, Stan Krolczyk, Kathryn M Dahir
OBJECTIVES: Rare metabolic bone diseases can present with symptoms mimicking more common rheumatological conditions including spondyloarthritis, osteoarthritis, and fibromyalgia. Increasing awareness of these rare diseases within the rheumatology community is vital to ensure that affected patients are diagnosed and appropriately treated. The literature includes several reports of tumour-induced osteomalacia initially diagnosed as rheumatic disease, but other rare diseases such as X-linked hypophosphatemia (XLH) and hypophosphatasia (HPP) also deserve attention...
2024: Case Reports in Rheumatology
#19
JOURNAL ARTICLE
James C Ross, Raul San José Estépar, Sam Ash, Carrie Pistenmaa, MeiLan Han, Surya P Bhatt, Sandeep Bodduluri, David Sparrow, Jean-Paul Charbonnier, George R Washko, Alejandro A Diaz
BACKGROUND: Abnormal lung function trajectories are associated with increased risk of chronic obstructive pulmonary disease (COPD) and premature mortality; several risk factors for following these trajectories have been identified. Airway under-sizing dysanapsis (small airway lumens relative to lung size), is associated with an increased risk for COPD. The relationship between dysanapsis and lung function trajectories at risk for adverse outcomes of COPD is largely unexplored. We test the hypothesis that dysanapsis differentially affects distinct lung function trajectories associated with adverse outcomes of COPD...
February 2024: EClinicalMedicine
#20
REVIEW
Fatemehsadat Pezeshkian, Miles McAllister, Anupama Singh, Michael T Jaklitsch, Ritu R Gill, Raphael Bueno, Antonio Coppolino
Lung cancer screening techniques using low-dose computed tomography (LDCT) scans have improved over the last decade. This means that there is an increased rate of detection of small, often non-palpable, nodules and ground-glass opacities. Obtaining a definitive diagnosis of these nodules using techniques such as percutaneous image-guided biopsy or intraoperative localization is challenging, and these nodules have traditionally undergone routine surveillance. Image-guided video-assisted thoracoscopic surgery (iVATS), which is performed in a hybrid operating room, has made it more feasible to biopsy and resect these nodules...
December 30, 2023: Journal of Thoracic Disease
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