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https://www.readbyqxmd.com/read/29241640/association-of-anti-cyclic-citrullinated-protein-antibodies-erosions-and-rheumatoid-factor-with-disease-activity-and-work-productivity-a-patient-registry-study
#1
Evo Alemao, Zhenchao Guo, Michelle L Frits, Christine K Iannaccone, Nancy A Shadick, Michael E Weinblatt
OBJECTIVES: To evaluate associations between the presence of anti-cyclic citrullinated protein antibodies (anti-CCP) and rheumatoid factor (RF) and other outcomes, including joint erosions and both clinical and economic endpoints, in patients with rheumatoid arthritis (RA). METHODS: Data from the Brigham and Women's Hospital Rheumatoid Arthritis Sequential Study (BRASS), a prospective registry of adult RA patients with established or recent-onset RA, were analyzed...
October 13, 2017: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/29217138/durable-remission-for-a-woman-with-refractory-choriocarcinoma-treated-with-anti-endoglin-monoclonal-antibody-and-bevacizumab-a-case-from-the-new-england-trophoblastic-disease-center-brigham-and-women-s-hospital-and-dana-farber-cancer-institute
#2
Michael J Worley, Kevin M Elias, Neil S Horowitz, Bradley J Quade, Ross S Berkowitz
A 36-year-old with metastatic and refractory choriocarcinoma following single- and multi-agent chemotherapy and surgical metastectomy experienced a durable remission after receiving therapy with an anti-endoglin monoclonal antibody and bevacizumab. Treatment options and scientific advances in this disease are highlighted.
December 4, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/29203688/antihyperglycemic-agents-are-inversely-associated-with-intracranial-aneurysm-rupture
#3
Anil Can, Victor M Castro, Sheng Yu, Dmitriy Dligach, Sean Finan, Vivian S Gainer, Nancy A Shadick, Guergana Savova, Shawn Murphy, Tianxi Cai, Scott T Weiss, Rose Du
BACKGROUND AND PURPOSE: Previous studies have suggested a protective effect of diabetes mellitus on aneurysmal subarachnoid hemorrhage risk. However, reports are inconsistent, and objective measures of hyperglycemia in these studies are lacking. Our aim was to investigate the association between aneurysmal subarachnoid hemorrhage and antihyperglycemic agent use and glycated hemoglobin levels. METHODS: The medical records of 4701 patients with 6411 intracranial aneurysms, including 1201 prospective patients, diagnosed at the Massachusetts General Hospital and Brigham and Women's Hospital between 1990 and 2016 were reviewed and analyzed...
December 4, 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/29202938/prevalence-of-monoclonal-gammopathy-in-wild-type-transthyretin-amyloidosis
#4
Hallie I Geller, Avinainder Singh, Tara M Mirto, Robert Padera, Richard Mitchell, Jacob P Laubach, Rodney H Falk
OBJECTIVE: To evaluate the prevalence of monoclonal gammopathy (MG) in patients with wild-type transthyretin amyloidosis (ATTRwt) (formerly known as senile amyloidosis). PATIENTS AND METHODS: We retrospectively analyzed the serum protein electrophoresis and serum immunofixation results, free light chain (FLC) levels, and renal function of 113 consecutive patients with ATTRwt seen at the Brigham and Women's Hospital's Cardiac Amyloidosis Program between February 21, 2006, and November 9, 2016...
December 2017: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/29195494/implementation-of-a-workplace-intervention-using-financial-rewards-to-promote-adherence-to-physical-activity-guidelines-a-feasibility-study
#5
Elena Losina, Savannah R Smith, Ilana M Usiskin, Kristina M Klara, Griffin L Michl, Bhushan R Deshpande, Heidi Y Yang, Karen C Smith, Jamie E Collins, Jeffrey N Katz
BACKGROUND: We designed and implemented the Brigham and Women's Wellness Initiative (B-Well), a single-arm study to examine the feasibility of a workplace program that used individual and team-based financial incentives to increase physical activity among sedentary hospital employees. METHODS: We enrolled sedentary, non-clinician employees of a tertiary medical center who self-reported low physical activity. Eligible participants formed or joined teams of three members and wore Fitbit Flex activity monitors for two pre-intervention weeks followed by 24 weeks during which they could earn monetary rewards...
December 1, 2017: BMC Public Health
https://www.readbyqxmd.com/read/29191375/rheumatologic-symptoms-in-oncologic-patients-on-pd-1-inhibitors
#6
Wilson F Kuswanto, Lindsey A MacFarlane, Lydia Gedmintas, Alexandra Mulloy, Toni K Choueiri, Bonnie L Bermas
OBJECTIVE: Immune checkpoint inhibitors are effective cancer therapies that have been associated with immune-related adverse events (irAEs). Recent reports of irAEs describe symptoms resembling classic rheumatologic syndromes, most notably associated with cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) inhibitor blockade. Though cases have been described, there are fewer reports of rheumatologic disease associated with programmed cell death protein-1 (PD-1) inhibitors. Here, we describe a series of four patients presenting to the Brigham and Women's Hospital (BWH) Arthritis Center with de novo polymyalgia rheumatica (PMR)-type conditions and/or peripheral synovitis after treatment with PD-1/PD-Ligand 1 (PD-L1) pathway inhibitors...
October 31, 2017: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/29188853/computerized-cognitive-testing-for-use-in-clinical-trials-a-comparison-of-the-nih-toolbox-and-cogstate-c3-batteries
#7
R F Buckley, K P Sparks, K V Papp, M Dekhtyar, C Martin, S Burnham, R A Sperling, D M Rentz
BACKGROUND: As prevention trials for Alzheimer's disease move into asymptomatic populations, identifying older individuals who manifest the earliest cognitive signs of Alzheimer's disease is critical. Computerized cognitive testing has the potential to replace current gold standard paper and pencil measures and may be a more efficient means of assessing cognition. However, more empirical evidence about the comparability of novel computerized batteries to paper and pencil measures is required...
2017: Journal of Prevention of Alzheimer's Disease
https://www.readbyqxmd.com/read/29167275/residual-convolutional-neural-network-for-determination-of-idh-status-in-low-and-high-grade-gliomas-from-mr-imaging
#8
Ken Chang, Harrison X Bai, Hao Zhou, Chang Su, Wenya Linda Bi, Ena Agbodza, Vasileios K Kavouridis, Joeky T Senders, Alessandro Boaro, Andrew L Beers, Biqi Zhang, Alexandra Capellini, Weihua Liao, Qin Shen, Xuejun Li, Bo Xiao, Jane Cryan, Shakti Ramkissoon, Lori Ramkissoon, Keith L Ligon, Patrick Y Wen, Ranjit S Bindra, John H Woo, Omar Arnaout, Elizabeth Gerstner, Paul J Zhang, Bruce Rosen, Li Yang, Raymond Y Huang, Jayashree Kalpathy-Cramer
PURPOSE: Isocitrate dehydrogenase (<IDH) mutations in glioma patients confer longer survival and may guide treatment decision-making. We aimed to predict the IDH status of gliomas from MR imaging by applying a residual convolutional neural network to pre-operative radiographic data. EXPERIMENTAL DESIGN: Preoperative imaging was acquired for 201 patients from the Hospital of University of Pennsylvania (HUP), 157 patients from Brigham and Women's Hospital (BWH), and 138 patients from The Cancer Imaging Archive (TCIA) and divided into training, validation, and testing sets...
November 22, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29156486/-update-in-obstetric-anesthesia-tried-and-trusted-methods-controversies-and-new-perspectives
#9
Peter Kranke, Thorsten Annecke, Dorothee H Bremerich, Daniel Chappell, Thierry Girard, Wiebke Gogarten, Robert Hanß, Lutz Kaufner, Sophie Neuhaus, Tobias Ninke, Thomas Standl, Stefan Weber, Yvonne Jelting, Thomas Volk
Since 1975, a plethora of lectures within the context of annual meetings relevant for the clinical care has been summarized in "what's new in obstetric anesthesia" by the society for Obstetric anesthesia and Perinatology which can be recommended to everyone interested in anaesthesiology in the delivery room. After the death of Gerard W. Ostheimer, Professor of Anaesthesiology at Brigham and Women's Hospital in Boston, Massachusetts, it became renamed the Gerard W. Ostheimer "what's new in obstetric anesthesia" lecture to honor his contributions to regional anesthesia and obstetric anaesthesia...
November 2017: Anästhesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie: AINS
https://www.readbyqxmd.com/read/29133219/dietary-fatty-acid-modification-for-the-treatment-of-aspirin-exacerbated-respiratory-disease-a-prospective-pilot-trial
#10
Thomas R Schneider, Christina B Johns, Marina L Palumbo, Katherine C Murphy, Katherine N Cahill, Tanya M Laidlaw
BACKGROUND: The high levels of eicosanoid production and the clinical efficacy of leukotriene-modifying pharmacotherapies for patients with aspirin-exacerbated respiratory disease (AERD) suggest that other interventions targeting arachidonic acid dysregulation may also improve disease control. OBJECTIVE: To assess the utility of a high omega-3/low omega-6 diet for the treatment of AERD. METHODS: Prospective, nonblinded dietary intervention in 10 adult patients with AERD at Brigham and Women's Hospital in Boston, MA...
November 10, 2017: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/29129576/cardiometabolic-outcomes-and-mortality-in-medically-treated-primary-aldosteronism-a-retrospective-cohort-study
#11
Gregory L Hundemer, Gary C Curhan, Nicholas Yozamp, Molin Wang, Anand Vaidya
BACKGROUND: Mineralocorticoid receptor (MR) antagonists are the recommended medical therapy for primary aldosteronism. Whether this recommendation effectively reduces cardiometabolic risk is not well understood. We aimed to investigate the risk of incident cardiovascular events in patients with primary aldosteronism treated with MR antagonists compared with patients with essential hypertension. METHODS: We did a cohort study using patients from a research registry from Brigham and Women's Hospital, Massachusetts General Hospital, and their affiliated partner hospitals...
November 9, 2017: Lancet Diabetes & Endocrinology
https://www.readbyqxmd.com/read/29127864/assessment-of-the-quality-of-anticoagulation-management-in-patients-with-pulmonary-arterial-hypertension
#12
Tamara Roldan, Elena Villamañán, Juan J Rios, Aaron B Waxman
BACKGROUND: Studies assessing the quality of anticoagulation therapy in patients with pulmonary arterial hypertension (PAH) have not been conducted. OBJECTIVE: To assess the quality of anticoagulation management, the rate of anticoagulation-related complications in patients with PAH, and to identify risk factors for poor anticoagulation. METHODS: This observational, retrospective cohort study included patients with confirmed PAH taking a regimen of oral anticoagulants from two centers: Brigham and Women's Hospital in Boston, and Hospital Universitario La Paz in Madrid from January 2009 to August 2015...
November 2, 2017: Thrombosis Research
https://www.readbyqxmd.com/read/29124043/activities-of-daily-living-measured-by-the-harvard-automated-phone-task-track-with-cognitive-decline-over-time-in-non-demented-elderly
#13
Gad A Marshall, Sarah L Aghjayan, Maria Dekhtyar, Joseph J Locascio, Kamal Jethwani, Rebecca E Amariglio, Keith A Johnson, Reisa A Sperling, Dorene M Rentz
Background: Impairment in activities of daily living is a major burden to both patients and caregivers. Mild impairment in instrumental activities of daily living is often seen at the stage of mild cognitive impairment. The field of Alzheimer's disease is moving toward earlier diagnosis and intervention and more sensitive and ecologically valid assessments of instrumental or complex activities of daily living are needed. The Harvard Automated Phone Task, a novel performance-based activities of daily living instrument, has the potential to fill this gap...
2017: Journal of Prevention of Alzheimer's Disease
https://www.readbyqxmd.com/read/29123016/the-use-of-hyperbaric-oxygen-for-the-prevention-and-management-of-osteoradionecrosis-of-the-jaw-a-dana-farber-brigham-and-women-s-cancer-center-multidisciplinary-guideline
#14
Ahmed Sultan, Glenn J Hanna, Danielle N Margalit, Nicole Chau, Laura A Goguen, Francisco M Marty, Guilherme Rabinowits, Jonathan D Schoenfeld, Stephen T Sonis, Tom Thomas, Roy B Tishler, Nathaniel S Treister, Alessandro Villa, Sook-Bin Woo, Robert Haddad, Hani Mawardi
No abstract text is available yet for this article.
November 2017: Oncologist
https://www.readbyqxmd.com/read/29103103/heroin-use-is-associated-with-ruptured-saccular-aneurysms
#15
Anil Can, Victor M Castro, Yildirim H Ozdemir, Sarajune Dagen, Dmitriy Dligach, Sean Finan, Sheng Yu, Vivian Gainer, Nancy A Shadick, Guergana Savova, Shawn Murphy, Tianxi Cai, Scott T Weiss, Rose Du
While cocaine use is thought to be associated with aneurysmal rupture, it is not known whether heroin use increases the risk of rupture in patients with non-mycotic saccular aneurysms. Our goal was to investigate the association between heroin and cocaine use and the rupture of saccular non-mycotic aneurysms. The medical records of 4701 patients with 6411 intracranial aneurysms, including 1201 prospective patients, diagnosed at the Brigham and Women's Hospital and Massachusetts General Hospital between 1990 and 2016 were reviewed and analyzed...
November 4, 2017: Translational Stroke Research
https://www.readbyqxmd.com/read/29098284/association-of-alterations-in-main-driver-genes-with-outcomes-of-patients-with-resected-pancreatic-ductal-adenocarcinoma
#16
Zhi Rong Qian, Douglas A Rubinson, Jonathan A Nowak, Vicente Morales-Oyarvide, Richard F Dunne, Margaret M Kozak, Marisa W Welch, Lauren K Brais, Annacarolina Da Silva, Tingting Li, Wanwan Li, Atsuhiro Masuda, Juhong Yang, Yan Shi, Mancang Gu, Yohei Masugi, Justin Bui, Caitlin L Zellers, Chen Yuan, Ana Babic, Natalia Khalaf, Andrew Aguirre, Kimmie Ng, Rebecca A Miksad, Andrea J Bullock, Daniel T Chang, Jennifer F Tseng, Thomas E Clancy, David C Linehan, Jennifer J Findeis-Hosey, Leona A Doyle, Aaron R Thorner, Matthew Ducar, Bruce Wollison, Angelica Laing, William C Hahn, Matthew Meyerson, Charles S Fuchs, Shuji Ogino, Jason L Hornick, Aram F Hezel, Albert C Koong, Brian M Wolpin
Importance: Although patients with resected pancreatic adenocarcinoma are at high risk for disease recurrence, few biomarkers are available to inform patient outcomes. Objective: To evaluate the alterations of the 4 main driver genes in pancreatic adenocarcinoma and patient outcomes after cancer resection. Design, Setting, and Participants: This study analyzed protein expression and DNA alterations for the KRAS, CDKN2A, SMAD4, and TP53 genes by immunohistochemistry and next-generation sequencing in formalin-fixed, paraffin-embedded tumors in 356 patients with resected pancreatic adenocarcinoma who were treated at the Dana-Farber/Brigham and Women's Cancer Center (October 26, 2002, to May 21, 2012), University of Rochester Medical Center (March 1, 2006, to November 1, 2013), or Stanford Cancer Institute (September 26, 1995, to May 22, 2013)...
November 2, 2017: JAMA Oncology
https://www.readbyqxmd.com/read/29069090/the-meld-plus-a-generalizable-prediction-risk-score-in-cirrhosis
#17
Uri Kartoun, Kathleen E Corey, Tracey G Simon, Hui Zheng, Rahul Aggarwal, Kenney Ng, Stanley Y Shaw
BACKGROUND AND AIMS: Accurate assessment of the risk of mortality following a cirrhosis-related admission can enable health-care providers to identify high-risk patients and modify treatment plans to decrease the risk of mortality. METHODS: We developed a post-discharge mortality prediction model for patients with a cirrhosis-related admission using a population of 314,292 patients who received care either at Massachusetts General Hospital (MGH) or Brigham and Women's Hospital (BWH) between 1992 and 2010...
2017: PloS One
https://www.readbyqxmd.com/read/29055473/the-effect-of-alcohol-and-red-wine-consumption-on-clinical-and-mri-outcomes-in-multiple-sclerosis
#18
Camilo Diaz-Cruz, Alicia S Chua, Muhammad Taimur Malik, Tamara Kaplan, Bonnie I Glanz, Svetlana Egorova, Charles R G Guttmann, Rohit Bakshi, Howard L Weiner, Brian C Healy, Tanuja Chitnis
BACKGROUND: Alcohol and in particular red wine have both immunomodulatory and neuroprotective properties, and may exert an effect on the disease course of multiple sclerosis (MS). OBJECTIVE: To assess the association between alcohol and red wine consumption and MS course. METHODS: MS patients enrolled in the Comprehensive Longitudinal Investigation of Multiple Sclerosis at the Brigham and Women's Hospital (CLIMB) who completed a self-administered questionnaire about their past year drinking habits at a single time point were included in the study...
October 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/29052706/association-of-an-electroencephalography-based-risk-score-with-seizure-probability-in-hospitalized-patients
#19
Aaron F Struck, Berk Ustun, Andres Rodriguez Ruiz, Jong Woo Lee, Suzette M LaRoche, Lawrence J Hirsch, Emily J Gilmore, Jan Vlachy, Hiba Arif Haider, Cynthia Rudin, M Brandon Westover
Importance: Continuous electroencephalography (EEG) use in critically ill patients is expanding. There is no validated method to combine risk factors and guide clinicians in assessing seizure risk. Objective: To use seizure risk factors from EEG and clinical history to create a simple scoring system associated with the probability of seizures in patients with acute illness. Design, Setting, and Participants: We used a prospective multicenter (Emory University Hospital, Brigham and Women's Hospital, and Yale University Hospital) database containing clinical and electrographic variables on 5427 continuous EEG sessions from eligible patients if they had continuous EEG for clinical indications, excluding epilepsy monitoring unit admissions...
December 1, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/29050063/-update-in-obstetric-anesthesia-tried-and-trusted-methods-controversies-and-new-perspectives-part-1
#20
Peter Kranke, Thorsten Annecke, Dorothee H Bremerich, Daniel Chappell, Thierry Girard, Wiebke Gogarten, Robert Hanß, Lutz Kaufner, Sophie Neuhaus, Tobias Ninke, Thomas Standl, Stefan Weber, Yvonne Jelting, Thomas Volk
Since 1975, a plethora of lectures within the context of annual meetings relevant for the clinical care has been summarized in "what's new in obstetric anesthesia" by the Society for Obstetric Anesthesia and Perinatology which can be recommended to everyone interested in anaesthesiology in the delivery room. After the death of Gerard W. Ostheimer, Professor of Anaesthesiology at Brigham and Women's Hospital in Boston, Massachusetts, it became renamed the Gerard W. Ostheimer "what's new in obstetric anesthesia" lecture to honor his contributions to regional anesthesia and obstetric anaesthesia...
October 2017: Anästhesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie: AINS
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