keyword
MENU ▼
Read by QxMD icon Read
search

"Brigham and Women's"

keyword
https://www.readbyqxmd.com/read/27881497/discovering-and-developing-successful-cardiovascular-therapeutics-a-conversation-with-james-n-topper-md-phd
#1
James N Topper, John D Rutherford
Dr James (also known as Jamie) N. Topper, MD, PhD, serves as Managing General Partner at Frazier Healthcare Partners, where he leads the Life Science Venture practice. In 2011, and 2016, he was named to the Midas List of leading venture capitalists, and, in 2013, he was recognized by Forbes as one of the top 10 healthcare investors. He has >25 years of experience working with entrepreneurs to found and build successful therapeutics-focused companies. Dr Topper holds a BS from the University of Michigan. He received an MD and PhD (in biophysics) from Stanford University School of Medicine...
November 15, 2016: Circulation
https://www.readbyqxmd.com/read/27849352/medical-home-transformation-and-breast-cancer-screening
#2
Amy W Baughman, Phyllis Brawarsky, Tracy Onega, Tor D Tosteson, Qianfei Wang, Anna N A Tosteson, Jennifer S Haas
OBJECTIVES: The patient-centered medical home (PCMH) continues to gain momentum as a primary care delivery system. We evaluated whether medical home transformation of primary care practices is associated with the use of breast cancer screening, a broadly endorsed preventive service. STUDY DESIGN: Retrospective cohort study evaluating 12 Brigham and Women's Hospital (BWH)-affiliated primary care clinics in greater Boston, Massachusetts. METHODS: Practice transformation was measured quarterly using a continuous PCMH transformation score (range = 0-100) modeled after National Committee for Quality Assurance recognition requirements...
November 1, 2016: American Journal of Managed Care
https://www.readbyqxmd.com/read/27831999/safety-of-propofol-for-oxygenator-exchange-in-extracorporeal-membrane-oxygenation
#3
Benjamin Hohlfelder, Paul M Szumita, Susan Lagambina, Gerald Weinhouse, Jeremy R DeGrado
The purpose of this analysis is to describe the safety of propofol administration in adult ECMO patients. We performed a prospective cohort analysis of patients utilizing ECMO at Brigham and Women's Hospital between February 2013 and October 2015. Patients were included if they utilized ECMO for at least 48 hours. The major endpoint of the analysis was the median oxygenator lifespan. Oxygenator exchanges were analyzed by the number of patients requiring an oxygenator exchange and the number of oxygenator exchanges per ECMO day...
November 9, 2016: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/27826755/using-machine-learning-to-parse-breast-pathology-reports
#4
Adam Yala, Regina Barzilay, Laura Salama, Molly Griffin, Grace Sollender, Aditya Bardia, Constance Lehman, Julliette M Buckley, Suzanne B Coopey, Fernanda Polubriaginof, Judy E Garber, Barbara L Smith, Michele A Gadd, Michelle C Specht, Thomas M Gudewicz, Anthony J Guidi, Alphonse Taghian, Kevin S Hughes
PURPOSE: Extracting information from electronic medical record is a time-consuming and expensive process when done manually. Rule-based and machine learning techniques are two approaches to solving this problem. In this study, we trained a machine learning model on pathology reports to extract pertinent tumor characteristics, which enabled us to create a large database of attribute searchable pathology reports. This database can be used to identify cohorts of patients with characteristics of interest...
November 8, 2016: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/27815294/q-a-omid-farokhzad-on-nanomedicine-in-cancer
#5
(no author information available yet)
Omid Farokhzad, MD, director of the Center for Nanomedicine at Brigham and Women's Hospital in Boston, MA, discusses the challenges of moving nanotherapies from the realm of academic innovation to the clinic, stressing the importance of thoroughly understanding the nano-bio interface and its complexities for successful translation.
November 4, 2016: Cancer Discovery
https://www.readbyqxmd.com/read/27794636/brigham-and-women-s-hospital-three-time-winner-of-the-american-pain-society-clinical-centers-of-excellence-award
#6
Edgar Ross
Edgar Ross speaks to Jade Parker, Commissioning Editor: Dr Edgar Ross is a member of the Anesthesia Department at Brigham and Women's Hospital. His main office is in Chesnut Hill, an ambulatory care center for Brigham and Women's hospital. He received his medical degree from Wayne State University School of Medicine and has been in practice for more than 30 years, 20 years in his current position at Brigham and Women's Hospital. His two main clinical interests are; the phone app which is designed to become the main clinical tool for patients and second, the relationship between opioids and angiogenesis...
January 2017: Pain Management
https://www.readbyqxmd.com/read/27789360/readmissions-after-umbilical-cord-blood-transplantation-and-impact-on-overall-survival
#7
Jennifer Crombie, Laura Spring, Shuli Li, Robert J Soiffer, Joseph H Antin, Edwin P Alyea, Brett Glotzbecker
Patients treated with allogeneic hematopoietic stem cell transplantation (SCT) have high rates of readmission, but the incidence after umbilical cord blood transplantation (UCBT) is poorly described. The goal of this study was to identify the incidence and risk factors for readmission after UCBT and the impact of readmission on overall survival (OS). A retrospective review of patients receiving a UCBT at Dana-Farber/Brigham and Women's Hospital between January 1, 2004 and December 31, 2013 was performed. The readmission rates 30 days after discharge from the UCBT admission and at day +100 after the UCBT were examined...
October 24, 2016: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/27773764/opened-proton-pump-inhibitor-capsules-reduce-time-to-healing%C3%A2-compared-with-intact-capsules-for-marginal-ulceration%C3%A2-following-roux-en-y-gastric-bypass
#8
Allison R Schulman, Walter Chan, Aiofe Devery, Michele B Ryan, Christopher C Thompson
BACKGROUND & AIMS: Marginal ulceration, or ulceration at the gastrojejunal anastomosis, is a common complication of Roux-en-Y gastric bypass (RYGB). Acidity likely contributes to the pathophysiology, and proton pump inhibitors (PPIs) frequently are prescribed for treatment. However, patients with gastric bypass only have a small gastric pouch and rapid small-bowel transit, which limits the opportunity for capsule breakdown and PPI absorption. Soluble PPIs (open capsules [OCs]) might be absorbed more easily than intact capsules (ICs)...
October 20, 2016: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/27772698/comparison-of-ambulatory-high-dose-intravenous-diuretic-therapy-to-standard-hospitalization-and-diuretic-therapy-for-treatment-of-acute-decompensated-heart-failure
#9
Leo F Buckley, Enrique Seoane-Vazquez, Judy W M Cheng, Ahmed Aldemerdash, Irene M Cooper, Lina Matta, Danika S Medina, Mandeep R Mehra, Kristina Navarro-Velez, Elaine L Shea, Joanne R Weintraub, Lynne W Stevenson, Akshay S Desai
Innovative treatment strategies for decompensated heart failure (HF) are required to achieve cost savings and improvements in outcomes. We developed a decision analytic model from a hospital perspective to compare 2 strategies for the treatment of decompensated HF, ambulatory diuretic infusion therapy, and hospitalization (standard care), with respect to total HF hospitalizations and costs. The ambulatory diuretic therapy strategy included outpatient treatment with high doses of intravenous loop diuretics in a specialized HF unit whereas standard care included hospitalization for intravenous loop diuretic therapy...
November 1, 2016: American Journal of Cardiology
https://www.readbyqxmd.com/read/27758967/intravenous-immune-globulin-stewardship-program-at-a-tertiary-academic-medical-center
#10
Megan A Rocchio, James W Schurr, Aaron P Hussey, Paul M Szumita
BACKGROUND: In October 2010, a pharmacist-driven stewardship program was implemented at the Brigham and Women's Hospital to ensure continued adherence to the prescribing guideline, focusing on indications for intravenous immune globulin (IVIG) use and dosing per ideal body weight. OBJECTIVE: The primary objective was to describe an IVIG stewardship program at a tertiary academic medical center. METHODS: This was a prospective, observational study from January 2013 through December 2014...
October 6, 2016: Annals of Pharmacotherapy
https://www.readbyqxmd.com/read/27720683/the-role-of-face-transplantation-in-the-self-inflicted-gunshot-wound
#11
Harriet Kiwanuka, Mario A Aycart, David F Gitlin, Elaine Devine, Bridget J Perry, Thet-Su Win, Ericka M Bueno, Muayyad Alhefzi, Nicco Krezdorn, Bohdan Pomahac
BACKGROUND: Facial self-inflicted gunshot wounds (SIGSWs) cause a devastating midfacial defect and pose a challenging problem to the reconstructive surgeon. Face transplantation (FT) has the potential for near-normal restoration in otherwise non-reconstructible defects. Two out of 7 FT recipients at Brigham and Women's Hospital (BWH) sustained SIGSWs. In this study, we illustrate the role of FT in the management of SIGSWs through an aesthetic, functional, and psychosocial examination of outcomes...
September 8, 2016: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://www.readbyqxmd.com/read/27707594/the-positive-impact-of-radiologic-imaging-on-high-stage-cutaneous-squamous-cell-carcinoma-management
#12
Emily Stamell Ruiz, Pritesh S Karia, Frederick C Morgan, Chrysalyne D Schmults
BACKGROUND: There is limited evidence on the utility of radiologic imaging for prognostic staging of cutaneous squamous cell carcinoma (CSCC). OBJECTIVE: Review utilization of radiologic imaging of high-stage CSCCs to evaluate whether imaging impacted management and outcomes. METHODS: Tumors classified as Brigham and Women's Hospital (BWH) tumor (T) stage T2B or T3 over a 13-year period were reviewed to identify whether imaging was performed and whether results affected treatment...
October 1, 2016: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/27665586/breast-cancer-screening-initiation-after-turning-40%C3%A2-years-of-age-within-the-prospr-consortium
#13
Elisabeth F Beaber, Anna N A Tosteson, Jennifer S Haas, Tracy Onega, Brian L Sprague, Donald L Weaver, Anne Marie McCarthy, Chyke A Doubeni, Virginia P Quinn, Celette Sugg Skinner, Ann G Zauber, William E Barlow
PURPOSE: Although United States clinical guidelines differ, the earliest recommended age for average risk breast cancer screening is 40 years. Little is known about factors influencing screening initiation. METHODS: We conducted a cohort study within the National Cancer Institute-funded Population-based Research Optimizing Screening through Personalized Regimens (PROSPR) consortium. We identified 3413 women on their 40th birthday in primary care networks at Geisel School of Medicine at Dartmouth (DH) and Brigham and Women's Hospital (BWH) during 2011-2013 with no prior breast imaging or breast cancer...
November 2016: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/27632672/human-sepsis-eicosanoid-and-proresolving-lipid-mediator-temporal-profiles-correlations-with-survival-and-clinical-outcomes
#14
Jesmond Dalli, Romain A Colas, Carolina Quintana, Diana Barragan-Bradford, Shelley Hurwitz, Bruce D Levy, Augustine M Choi, Charles N Serhan, Rebecca M Baron
OBJECTIVE: To identify and measure recently described chemical mediators, termed specialized pro-resolving mediators that actively regulate the resolution of acute-inflammation, and correlate measurements with clinical outcomes. DESIGN: Herein, deidentified plasma was collected from sepsis patients (n = 22 subjects) within 48 hours of admission to the ICU and on days 3 and 7 thereafter and subjected to lipid mediator profiling. SETTING: Brigham and Women's Hospital Medical Intensive Care Unit...
September 14, 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27627773/-principal-causes-for-recurrent-carpal-tunnel-syndrome
#15
M F Vázquez-Alonso, C Abdala-Dergal
The frequent causes of relapsing carpal tunnel syndrome were analyzed. Nine patients were followed-up from January 1st to December 31st, 2011. They underwent a physical exam and imaging tests. Pain was measured in all of them with the VAS, and the Brigham and Womens Hospital questionnaire was used to assess disability. Patients included seven females and two males; mean age was 52 years. Major causes for relapse included postoperative fibrosis with incomplete release in seven patients and incomplete release in two patients in whom minimally invasive approaches were used...
January 2016: Acta Ortopédica Mexicana
https://www.readbyqxmd.com/read/27567434/candidal-carriage-predicts-candidiasis-during-topical-immunosuppressive-therapy-a-preliminary-retrospective-cohort-study
#16
Sara Tejani, Ahmed Sultan, Ivan Stojanov, Sook-Bin Woo
OBJECTIVES: To determine (1) the prevalence of candidal carriage in patients with oral mucosal disease to be treated with topical immunosuppressive therapy, and (2) the incidence of oral candidiasis among carriers and noncarriers after initiation of therapy to assess any correlation between carriage and the development of candidiasis. STUDY DESIGN: Records of patients who underwent swab cultures for Candida between January 2009 and October 2014 at the Brigham and Women's Hospital in Boston, Massachusetts, were retrospectively reviewed...
October 2016: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
https://www.readbyqxmd.com/read/27470290/fludarabine-busulfan-versus-fludarabine-melphalan-conditioning-in-patients-undergoing-reduced-intensity-conditioning-hematopoietic-stem-cell-transplantation-for-lymphoma
#17
Natasha Kekre, Francisco J Marquez-Malaver, Monica Cabrero, Jl Piñana, Albert Esquirol, Robert J Soiffer, Dolores Caballero, M J Terol, Rodrigo Martino, Joseph H Antin, L Lopez-Corral, Carlos Solano, Philippe Armand, Jose A Pérez-Simon
There is at present little data to guide the choice of conditioning for patients with lymphoma undergoing reduced-intensity conditioning (RIC) allogeneic stem cell transplantation (SCT). In this study, we compared the outcomes of patients undergoing RIC SCT who received fludarabine and melphalan (FluMel), the standard RIC regimen used by the Spanish Group of Transplantation, and fludarabine and busulfan (FluBu), the standard RIC regimen used by the Dana-Farber Cancer Institute/Brigham and Women's Hospital. We analyzed 136 patients undergoing RIC SCT for lymphoma with either FluBu (n = 61) or FluMel (n = 75) conditioning between 2007 and 2014...
October 2016: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/27467562/vitamin-d-and-bronchopulmonary-dysplasia-in-preterm-infants
#18
K E Joung, H H Burris, L J Van Marter, T F McElrath, Z Michael, P Tabatabai, A A Litonjua, S T Weiss, H Christou
OBJECTIVE: Vitamin D deficiency is associated with asthma and reactive airway disease in childhood but its potential contribution to bronchopulmonary dysplasia (BPD) in preterm infants is unknown. Preterm infants have lower levels of 25-hydroxyvitamin D (25(OH)D) at birth and are at risk for nutritional deficiencies after birth. The objective of the study was to evaluate the association of 25(OH)D concentrations at birth and at 36 weeks' corrected gestational age with BPD in preterm infants born before 29 completed weeks of gestation...
October 2016: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/27467226/metastatic-cutaneous-squamous-cell-carcinoma-the-importance-of-t2-stratification-and-hematologic-malignancy-in-prognostication
#19
Mary L Stevenson, Randie Kim, Shane A Meehan, Anna C Pavlick, John A Carucci
BACKGROUND: While infrequent, nodal metastases in cutaneous squamous cell carcinoma (cSCC) can result in death from disease. Identification of those at risk for metastases is key to improved prognostication and treatment. OBJECTIVE: To review metastatic cSCC at the study institution. METHODS AND MATERIALS: Sixteen patients with metastatic cSCC were identified at the New York University Dermatologic Associates and Cancer Associates from 1998 to 2013...
August 2016: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/27465417/five-year-institutional-bibliometric-profiles-for-119-north-american-neurosurgical-residency-programs-an-update
#20
Ryan P Lee, Garrett T Venable, Mallory L Roberts, Kara A Parikh, Douglas R Taylor, Nickalus Khan, L Madison Michael, Paul Klimo
BACKGROUND: We recently performed a comprehensive bibliometric analysis of 103 US neurosurgical departments and found the ih(5)-index as meaningful and reproducible using public data. The present report expands this analysis by adding 14 Canadian and 2 additional US programs. METHODS: Departments were included if listed on the American Association of Neurological Surgeons residency directory. Each institution was considered a single entity, and original research articles with neurosurgeon faculty authors were only counted once per institution, although a single article may have been credited toward multiple institutions, if applicable...
July 25, 2016: World Neurosurgery
keyword
keyword
11579
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"