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Chordomas

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https://www.readbyqxmd.com/read/28346646/metastatic-chordoma-of-the-tongue-case-report
#1
Sultan Bişkin, Rabiye Uslu Erdemir, Sultan Şevik Eliçora, Sevim Aydınlı, Şükrü Oğuz Özdamar
Chordomas are rare bone tumors that arise from notochord remnants. They most commonly occur in the sacrum, but they also can be seen in the skull base, cervical spine, and thoracolumbar vertebrae. Chordomas account for 1 to 4% of all primary skeletal tumors. They are usually indolent, locally growing tumors. Distant metastasis has been reported in 3 to 48% of cases. When metastasis occurs, it is usually observed in the lung, bone, and liver. To the best of our knowledge, no case of a chordoma metastasis to the tongue has been previously reported in the literature...
March 2017: Ear, Nose, & Throat Journal
https://www.readbyqxmd.com/read/28327915/vascularized-fibular-strut-autografts-in-spinal-reconstruction-after-resection-of-vertebral-chordoma-or-chondrosarcoma-a-retrospective-series
#2
Vijay Yanamadala, Peter A Rozman, Jay I Kumar, Joseph H Schwab, Sang-Gil Lee, Francis J Hornicek, William T Curry
BACKGROUND: Margin-free en bloc resection is the best medical practice for primary vertebral chordoma and chondrosarcoma. Spinal reconstruction following total spondylectomy requires reconstructive interbody graft (allograft, devascularized autograft, vascularized autograft, or cage constructs) and instrumentation. An important consideration when choosing grafts and instrumentation is the durability and the long-term success of the fusion without subsidence. OBJECTIVE: To evaluate the potential use of vascularized fibular autograft as a reconstructive strategy after en bloc resection...
January 13, 2017: Neurosurgery
https://www.readbyqxmd.com/read/28315176/symptom-burden-and-life-challenges-reported-by-adult-chordoma-patients-and-their-caregivers
#3
Paula H Song, Hadi Beyhaghi, Josh Sommer, Antonia V Bennett
PURPOSE: This study aims to characterize the symptom burden and life challenges that chordoma patients and their caregivers experience. METHODS: In this cross-sectional study, we analyzed data from the Chordoma Foundation online community survey conducted in 2014. Frequency counts and percentages were calculated to determine the prevalence of self-reported symptoms and life challenges in the sample. We used Fisher's exact test to compare self-reported symptoms among subgroups with different disease status, tumor locations, and treatments received...
March 17, 2017: Quality of Life Research
https://www.readbyqxmd.com/read/28304223/metastatic-clival-chordoma-a-case-report-of-multiple-extraneural-metastases-following-resection-and-proton-beam-radiotherapy-in-a-5-year-old-boy
#4
Martin J Rutkowski, Harjus S Birk, Matthew D Wood, Arie Perry, Theodore Nicolaides, Christopher P Ames, Nalin Gupta
The authors report the case of a 5-year-old boy in whom extraneural metastases developed 5 years after he underwent an occipitocervical fusion and transoral approach to treat a clival chordoma without local recurrence. Following primary resection, the patient's postoperative course was complicated by recurrent meningitis secondary to CSF leak, which responded to antibiotics, and communicating hydrocephalus, for which a ventriculoperitoneal shunt was placed. The patient then underwent postoperative proton beam radiotherapy...
March 17, 2017: Journal of Neurosurgery. Pediatrics
https://www.readbyqxmd.com/read/28297453/spot-scanning-proton-therapy-minimizes-neutron-dose-in-the-setting-of-radiation-therapy-administered-during-pregnancy
#5
Xin Wang, Falk Poenisch, Narayan Sahoo, Ronald X Zhu, MingFwu Lii, Michael T Gillin, Jing Li, David Grosshans
This is a real case study to minimize the neutron dose equivalent (H) to a fetus using spot scanning proton beams with favorable beam energies and angles. Minimum neutron dose exposure to the fetus was achieved with iterative planning under the guidance of neutron H measurement. Two highly conformal treatment plans, each with three spot scanning beams, were planned to treat a 25-year-old pregnant female with aggressive recurrent chordoma of the base of skull who elected not to proceed with termination. Each plan was scheduled for delivery every other day for robust target coverage...
September 2016: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28291405/letter-to-the-editor-influence-of-age-on-survival-outcomes-in-patients-with-spinal-chordoma
#6
Ming-Xiang Zou, Jing Li, Xiao-Bin Wang, Guo-Hua Lv
No abstract text is available yet for this article.
February 24, 2017: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/28272674/the-role-of-egfr-hepatocyte-growth-factor-receptor-c-met-c-erbb2-her2-neu-and-clinicopathological-parameters-in-the-pathogenesis-and-prognosis-of-chordoma
#7
Zeynep Tosuner, Süheyla Uyar Bozkurt, Türker Kiliç, Baran Yilmaz
OBJECTIVE: Chordoma is a rare malignant bone tumor with a poor outcome. Although radiotherapy and gamma knife surgery have been used for treatment, providing a cure for the tumor is not easy, because of the frequent recurrences. Molecular targeted therapy against tyrosine kinases has been effective in the treatment of malignancies such as breast and lung cancers and brain tumors. We aimed to analyse the histopathological features of chordomas and the immunoexpression profiles of the three receptor tyrosine kinases of EGFR, c-Met and c-Erb-B2 in chordomas...
February 4, 2017: Türk Patoloji Dergisi
https://www.readbyqxmd.com/read/28247842/leukemia-inhibitory-factor-promotes-aggressiveness-of-chordoma
#8
Sukru Gulluoglu, Mesut Sahin, Emre Can Tuysuz, Cumhur Kaan Yaltirik, Aysegul Kuskucu, Ferda Ozkan, Fikrettin Sahin, Ugur Ture, Omer Faruk Bayrak
Chordomas are rare tumors of the spine and skull base that are locally destructive and resistant to chemo- and radiation therapy, with a poor prognosis and limited therapeutic options. Chordoma patients have a long life expectancy with high mortality from the disease. Cancer stem cells, which are known to exist in chordomas, have extensive proliferative and self-renewal potential, and are responsible for maintaining tumor heterogeneity along with chemotherapy and radiotherapy resistance. The leukemia inhibitory factor has multiple functions in stem-cell biology, the immune response, and cancer, and is potentially a key molecule that allows cancer stem cells to self-renew...
February 28, 2017: Oncology Research
https://www.readbyqxmd.com/read/28242157/-cervical-paraspinal-chordoma-a-condition-we-should-know-a-case-report
#9
Juan Mesa-Quesada, Elisa Roldán-Romero, Jesús A Lozano-Sánchez, Macarena Centeno-Haro, Rosa M Ortega-Salas, Francisco Bravo-Rodríguez
Chordoma is a rare, slow-growing tumour arising from remnants of the notochord. It is most often located in the base of the skull and the sacrococcygeal region, being located in the cervical region in only 6% of cases. A rare case is presented of a left para-spinal chordoma, of which less than 10 cases have been reported in literature. It was located at C2-C4 level in a young male with no personal history of interest. Radiographic findings suggested that this was a slow-growing tumour, of cystic dominance, which eroded the bone structures and encompassed the left vertebral artery...
February 24, 2017: Neurocirugía
https://www.readbyqxmd.com/read/28228324/extended-maxillotomy-for-skull-base-access-in-contemporary-management-of-chordomas-rationale-and-technical-aspect
#10
Muhammad Fahmi Abdul Jalil, Rowan D Story, Myron Rogers
Minimally invasive approaches to the central skull base have been popularized over the last decade and have to a large extent displaced 'open' procedures. However, traditional skull base surgery still has its role especially when dealing with a large clival chordoma where maximal surgical resection is the principal goal to maximize patient survival. In this paper, we present a case of a 25year-old male patient with chordoma in the inferior clivus which was initially debulked via a transnasal endoscopic approach...
February 19, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28218953/glial-papillary-tumour-of-the-spinal-cord-with-smarcb1-ini1-loss-and-favourable-long-term-outcome
#11
Martin Hasselblatt, Anastasia Dewi Kurniawan, Stephanie Rozsnoki, Pascal D Johann, Susanne Bens, Florian Oyen, Reinhard Schneppenheim, Reiner Siebert, David Capper, Marcel Kool, Christoph Schul, Werner Paulus
Rhabdoid phenotype and biallelic mutations of the SMARCB1 gene causing loss of SMARCB1/INI1 protein expression are the hallmark of atypical teratoid/rhabdoid tumour (AT/RT), a highly malignant central nervous system tumour mainly affecting infants [1]. Loss of SMARCB1/INI1 protein expression has also been described in a variety of other rhabdoid and non-rhabdoid tumour entities including cribriform neuroepithelial tumour (CRINET) [2], poorly differentiated chordoma [3] as well as rhabdoid peripheral nerve sheath tumour [4] and familial schwannomatosis [5]...
February 20, 2017: Neuropathology and Applied Neurobiology
https://www.readbyqxmd.com/read/28216213/expression-of-cathepsin-k-in-skull-base-chordoma
#12
Kaibing Tian, Junpeng Ma, Liang Wang, Ke Wang, Da Li, Shuyu Hao, Yang Yang, Jiang Du, Guijun Jia, Liwei Zhang, Zhen Wu, Junting Zhang
OBJECTIVE: The objective of this study is to explore the association between cathepsin K and the clinical characteristics of skull base chordoma (SBC). METHODS: In this study, 58 paraffin-embedded samples and 85 frozen samples of 94 patients were included. All clinical data corresponding to these patients were available. Immunohistochemical staining and Quantitative Real-time polymerase chain reaction were performed. Positive rate of Immunohistochemical staining slices and delta CT value of Quantitative Real-time polymerase chain reaction represent the cathepsin K expression level in protein and gene level separately...
February 12, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28188186/nccn-guidelines-insights-bone-cancer-version-2-2017
#13
J Sybil Biermann, Warren Chow, Damon R Reed, David Lucas, Douglas R Adkins, Mark Agulnik, Robert S Benjamin, Brian Brigman, G Thomas Budd, William T Curry, Aarati Didwania, Nicola Fabbri, Francis J Hornicek, Joseph B Kuechle, Dieter Lindskog, Joel Mayerson, Sean V McGarry, Lynn Million, Carol D Morris, Sujana Movva, Richard J O'Donnell, R Lor Randall, Peter Rose, Victor M Santana, Robert L Satcher, Herbert Schwartz, Herrick J Siegel, Katherine Thornton, Victor Villalobos, Mary Anne Bergman, Jillian L Scavone
The NCCN Guidelines for Bone Cancer provide interdisciplinary recommendations for treating chordoma, chondrosarcoma, giant cell tumor of bone, Ewing sarcoma, and osteosarcoma. These NCCN Guidelines Insights summarize the NCCN Bone Cancer Panel's guideline recommendations for treating Ewing sarcoma. The data underlying these treatment recommendations are also discussed.
February 2017: Journal of the National Comprehensive Cancer Network: JNCCN
https://www.readbyqxmd.com/read/28184416/best-practices-for-the-management-of-local-regional-recurrent-chordoma-a-position-paper-by-the-chordoma-global-consensus-group
#14
S Stacchiotti, A Gronchi, P Fossati, T Akiyama, C Alapetite, M Baumann, J Y Blay, S Bolle, S Boriani, P Bruzzi, R Capanna, A Caraceni, R Casadei, V Colia, J Debus, T Delaney, A Desai, P Dileo, S Dijkstra, F Doglietto, A Flanagan, S Froelich, P A Gardner, H Gelderblom, Z L Gokaslan, R Haas, C Heery, N Hindi, P Hohenberger, F Hornicek, R Imai, L Jeys, R L Jones, B Kasper, A Kawai, M Krengli, A Leithner, I Logowska, J Martin Broto, D Mazzatenta, C Morosi, P Nicolai, O J Norum, S Patel, N Penel, P Picci, S Pilotti, S Radaelli, F Ricchini, P Rutkowski, S Scheipl, C Sen, E Tamborini, K A Thornton, B Timmermann, V Torri, P U Tunn, M Uhl, Y Yamada, D C Weber, D Vanel, P P Varga, C LA Vleggeert-Lankamp, P G Casali, J Sommer
No abstract text is available yet for this article.
February 9, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/28182320/proton-beam-therapy-for-bone-sarcomas-of-the-skull-base-and-spine-a-retrospective-nationwide-multicenter-study-in-japan
#15
Yusuke Demizu, Masashi Mizumoto, Tsuyoshi Onoe, Naoki Nakamura, Yasuhiro Kikuchi, Tetsushi Shibata, Tomoaki Okimoto, Sakurai Hideyuki, Tetsuo Akimoto, Kota Ono, Takashi Daimon, Shigeyuki Murayama
We conducted a retrospective, nationwide multicenter study to evaluate the clinical outcomes of proton beam therapy for bone sarcomas of the skull base and spine in Japan. Eligibility criteria included: (1) histologically proven bone sarcomas of the skull base or spine, (2) no metastases, (3) ≥20 years of age, and (4) no prior treatment with radiotherapy. Of the 103 patients treated between January 2004 and January 2012, we retrospectively analyzed data from 96 patients who were followed-up for >6 months or had died within 6 months...
February 9, 2017: Cancer Science
https://www.readbyqxmd.com/read/28179707/cervical-chordoma-involving-c3-c4-a-case-report
#16
Muhammad Imran, Atiq Ahmed Khan, Syed Muneeb Younus
Chordoma is a rare, indolent but locally invasive, osteolytic, slow growing, low grade, primary bone malignancy, derived from the embryonic remnants of the notochord. It is a midline tumour and it predominantly emerges from the axial skeleton. The most commonly observed location of a chordoma is in the sacrococcygeal region ( 50 to 55% ) followed by the cranio occipital region ( 25 to 30% )We present a case of a 30 years old lady who came to us with complaints of difficulty in walking and inability to hold objects in both hands...
December 2016: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/28175529/365%C3%A2-epigenetic-profiling-reveals-a-unique-histone-code-in-chordoma
#17
Nelson Moussazadeh, Samuel H Berman, Ilya Laufer, Mrinal Gounder, Yupeng Zheng, Joshua Sommer, Mark H Bilsky, Neil L Kelleher, Cameron Brennan
No abstract text is available yet for this article.
August 1, 2016: Neurosurgery
https://www.readbyqxmd.com/read/28175422/130%C3%A2-skull-base-chordomas-in-children-and-young-adults
#18
M Maher Hulou, Marcio S Rassi, Kaith Almefty, Wenya Linda Bi, Ian F Dunn, Timothy R Smith, Ossama Al-Mefty
No abstract text is available yet for this article.
August 1, 2016: Neurosurgery
https://www.readbyqxmd.com/read/28166150/68ga-dota-tate-pet-ct-for-molecular-imaging-of-somatostatin-receptor-expression-in-metastasizing-chordoma-comparison-with-18f-fdg
#19
Thorsten Derlin, Jan M Sohns, Katja Hueper
Chordoma is a rare slow-growing neoplasm of neuroectodermal origin, which frequently recurs after removal and has the potential to metastasize. We present the case of a 53-year-old man with metastasizing chordoma who underwent F-FDG and Ga-DOTA-TATE PET/CT for restaging of disease and for evaluation of targeted radionuclide therapy potential. On both F-FDG and Ga-DOTA-TATE PET scans, increased tracer accumulation was observed in chordoma metastases. Besides the increased glucose metabolism in chordoma, this case highlights the potential of Ga-DOTA-TATE PET/CT for restaging of chordoma as well the option of targeted radionuclide therapy in this entity...
February 3, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28153624/the-adult-apical-ligament-of-the-dens-does-not-contain-notochordal-tissue-application-to-better-understanding-the-origins-of-skull-base-chordomas
#20
Christian Fisahn, Cameron Schmidt, Steven Rostad, Rong Li, Tarush Rustagi, Fernando Alonso, Mohammadali M Shoja, Joe Iwanaga, Jens R Chapman, Rod J Oskouian, R Shane Tubbs
INTRODUCTION: The apical ligament has long been reported to contain notochord remnants and thus might serve as a site of origin of chordoma formation at the skull base. However, to our knowledge, the histological study of the apical ligament using histological staining specific for notochordal tissue has not been previously performed. Therefore, the current study was undertaken. METHODS: Fifteen apical ligament samples underwent histological examination with specific markers for notochordal differentiation...
January 30, 2017: World Neurosurgery
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