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https://www.readbyqxmd.com/read/27903019/osteochondroma-presenting-as-a-calcified-mass-in-the-sellar-region-and-review-of-the-literature
#1
Kazuya Sekiguchi, Satoshi Tsutsumi, Sho Arai, Senshu Nonaka, Takamoto Suzuki, Hisato Ishii, Hiroshi Izumi, Yukimasa Yasumoto
Objective Osteochondroma (OC) is the most common benign bone neoplasm. It infrequently occurs in the cranial cavity as a calcified lesion and very rarely presents in the sellar region. The present study summarizes the knowledge about OCs of the sellar region. Methods We searched the literature search for the clinical appearance of OCs and other calcified pathologies occurring in the sellar region. Results A total of 21 English-language articles published from 1961 to 2015 documented cases of calcified lesions in the sellar region including cerebral aneurysm, chondroid chordoma, chondroma, craniopharyngioma, OC, odontome, osteoma, pituitary adenoma, pituitary stone, Rathke cleft cyst, retinoblastoma, schwannoma, and xanthogranuloma...
November 30, 2016: Journal of Neurological Surgery. Part A, Central European Neurosurgery
https://www.readbyqxmd.com/read/27901492/genomic-and-transcriptomic-characterization-of-skull-base-chordoma
#2
Jason K Sa, In-Hee Lee, Sang Duk Hong, Doo-Sik Kong, Do-Hyun Nam
Skull base chordoma is a primary rare malignant bone-origin tumor showing relatively slow growth pattern and locally destructive lesions, which can only be characterized by histologic components. There is no available prognostic or therapeutic biomarker to predict clinical outcome or treatment response and the molecular mechanisms underlying chordoma development still remain unexplored. Therefore, we sought out to identify novel somatic variations that are associated with chordoma progression and potentially employed as therapeutic targets...
November 25, 2016: Oncotarget
https://www.readbyqxmd.com/read/27900552/giant-chordoma-in-the-thoracolumbar-spine-a-case-report-and-literature-review
#3
Feifei Pu, Baichuan Wang, Jianxiang Liu, Fengxia Chen, Zengwu Shao
STUDY DESIGN: Case report. PURPOSE: We present a rare case of a giant chordoma in the thoracolumbar spine and review the current literature. We describe its complicated clinical progression, hoping to shed light on the clinical management of this complex tumor. METHODS: We present a previously healthy 41-year-old man who experienced progressive low back pain at T10-L2 for the past 2 years. A giant tumor was detected on magnetic resonance imaging, and aspiration biopsy was used to obtain a definite pathological diagnosis...
November 29, 2016: European Spine Journal
https://www.readbyqxmd.com/read/27869082/reoptimization-of-intensity-modulated-proton-therapy-plans-based-on-linear-energy-transfer
#4
Jan Unkelbach, Pablo Botas, Drosoula Giantsoudi, Bram L Gorissen, Harald Paganetti
PURPOSE: We describe a treatment plan optimization method for intensity modulated proton therapy (IMPT) that avoids high values of linear energy transfer (LET) in critical structures located within or near the target volume while limiting degradation of the best possible physical dose distribution. METHODS AND MATERIALS: To allow fast optimization based on dose and LET, a GPU-based Monte Carlo code was extended to provide dose-averaged LET in addition to dose for all pencil beams...
December 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27857879/stat3-inhibition-as-a-therapeutic-strategy-for-chordoma
#5
Anthony C Wang, John H Owen, Waleed M Abuzeid, Shawn L Hervey-Jumper, Xiaobing He, Mikel Gurrea, Meijuan Lin, David B Altshuler, Richard F Keep, Mark E Prince, Thomas E Carey, Xing Fan, Erin L McKean, Stephen E Sullivan
Objective Signal transducer and activator of transcription (STAT) proteins regulate key cellular fate decisions including proliferation and apoptosis. STAT3 overexpression induces tumor growth in multiple neoplasms. STAT3 is constitutively activated in chordoma, a tumor with a high recurrence rate despite maximal surgical and radiation treatment. We hypothesized that a novel small molecule inhibitor of STAT3 (FLLL32) would induce significant cytotoxicity in sacral and clival chordoma cells. Methods Sacral (UCh1) and clival (UM-CHOR-1) chordoma cell lines were grown in culture (the latter derived from primary tumor explants)...
December 2016: Journal of Neurological Surgery. Part B, Skull Base
https://www.readbyqxmd.com/read/27856381/what-questionnaires-to-use-when-measuring-quality-of-life-in-sacral-tumor-patients-the-updated-sacral-tumor-survey
#6
Olivier D R van Wulfften Palthe, Stein J Janssen, Jay S Wunder, Peter C Ferguson, Guo Wei, Peter S Rose, Micheal J Yaszemski, Franklin H Sim, Patrick J Boland, John H Healey, Francis J Hornicek, Joseph H Schwab
BACKGROUND CONTEXT: Patient reported outcomes are becoming increasingly important when investigating results of patient and disease management. In sacral tumor patients symptoms can vary substantially, therefore no single questionnaire can adequately account for the full spectrum of symptoms and disability. PURPOSE: The purpose of this study is to analyze redundancy within the current sacral tumor survey and make a recommendation for an updated version based on the results and patient and expert opinions...
November 14, 2016: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/27844229/one-step-reconstruction-with-a-3d-printed-custom-made-prosthesis-after-total-en-bloc-sacrectomy-a-technical-note
#7
Ran Wei, Wei Guo, Tao Ji, Yidan Zhang, Haijie Liang
BACKGROUND: Surgeries for primary malignancies involving upper sacrum require total en bloc sacrectomy followed by complex mechanical reconstruction, which might be simplified by application of the three-dimensional (3D) printing technique. PURPOSES: To describe the design of a 3D-printed custom-made prosthesis for reconstruction after total en bloc sacrectomy, the surgical technique, and the clinical and functional outcome of a patient. METHODS: A 62-year-old patient with recurrent sacral chordoma was admitted in our center...
November 14, 2016: European Spine Journal
https://www.readbyqxmd.com/read/27822356/efficacy-of-pazopanib-and-sunitinib-in-advanced-axial-chordoma-a-single-reference-centre-case-series
#8
Astrid Lipplaa, Sander Dijkstra, Hans Gelderblom
BACKGROUND: Chordomas are rare malignant tumours of the axial skeleton and skull base supposed to arise from cellular remnants of the notochord. These tumours have the potential to metastasize (30-40 %), usually in the later course of the disease. However, the greatest morbidity is usually a result of loco-regional recurrence with infiltration and destruction of surrounding bone and soft tissue. Patients with unresectable or metastatic chordoma are faced with a poor prognosis since cytotoxic chemotherapy or other systemic therapies have not proven their efficacy yet...
2016: Clinical Sarcoma Research
https://www.readbyqxmd.com/read/27819871/atypical-notochordal-cell-tumors-a-series-of-notochordal-derived-tumors-that-defy-current-classification-schemes
#9
Jodi M Carter, Doris E Wenger, Peter S Rose, Carrie Y Inwards
By the current WHO classification, benign notochordal cell tumor (BNCT) and chordoma comprise the entire spectrum of notochordal-derived tumors. They have defined radiologic and histologic criteria, and differ considerably in management and clinical outcome. Chordomas are malignant tumors; they show progressive, destructive growth and have the capacity for metastasis. In contrast, BNCT are benign and show limited intraosseous growth. Patients with BNCT can be managed with serial imaging or conservative excision, whereas patients with spinal/sacral chordomas typically undergo radical en bloc resection often with adjuvant therapy and significant morbidity...
November 4, 2016: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/27760458/chordomas-and-chondrosarcomas-the-role-of-radiation-therapy
#10
Karen De Amorim Bernstein, Thomas DeLaney
Achieving negative surgical margins can be challenging for skull base and spinal/paraspinal sarcomas. Data shows that pre- or post-operative radiation therapy improves local control. Delivery of sufficient dose of radiation can be difficult because of the proximity to normal organs/tissues that are sensitive to radiation therapy and therefore dose-limiting. A comprehensive literature search was conducted using PubMed search engine. The scarcity of prospective, randomized data limits the ability to generate definitive treatment recommendations...
October 2016: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/27755208/cutaneous-metastasis-from-sacral-chordoma
#11
Kristyna Gleghorn, Brandon Goodwin, Ramon Sanchez
Chordoma is a rare primary bone malignancy of notochord origin, representing 1-4% of malignant bone tumors. Typically, chordomas follow a slow progressive course with aggressive local extension, multiple recurrences, and metastases. Of particular interest to this case, cutaneous metastasis is exceedingly rare. Diagnosis of this entity can be a challenge due to the rarity of chordoma, as well as the infrequent presentation of distant cutaneous metastasis and non-specific clinical skin findings. We report a case of a 61-year-old male with a history of sacral chordoma treated by wide local excision 8 years prior to presentation developed a nodule on his scalp for 6 weeks...
October 14, 2016: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/27753788/tumor-size-as-a-prognostic-factor-in-spinal-chordoma-a-systematic-literature-review
#12
Ming-Xiang Zou, Guo-Hua Lv, Xiao-Bin Wang, Jing Li
No abstract text is available yet for this article.
October 6, 2016: Spine
https://www.readbyqxmd.com/read/27753782/management-of-locally-recurrent-chordoma-of-the-mobile-spine-and-sacrum-a-systematic-review
#13
Tamir Ailon, Radmehr Torabi, Charles G Fisher, Laurence D Rhines, Michelle J Clarke, Chetan Bettegowda, Stefano Boriani, Yoshiya J Yamada, Norio Kawahara, Peter P Varga, John H Shin, Arjun Saghal, Ziya L Gokaslan
STUDY DESIGN: Systematic review. OBJECTIVE: To determine evidence-based guidelines for the management of locally recurrent spinal chordoma. SUMMARY OF BACKGROUND DATA: Chordoma of the spine is a low-grade malignant tumor with a strong propensity for local recurrence. Salvage therapy is challenging due to its relentless nature and refractoriness to adjuvant therapies. There are currently no guidelines regarding the best management of recurrent chordoma...
October 15, 2016: Spine
https://www.readbyqxmd.com/read/27737652/ct-guided-cryoablation-for-locally-recurrent-or-metastatic-bone-and-soft-tissue-tumor-initial-experience
#14
Michiro Susa, Kazutaka Kikuta, Robert Nakayama, Kazumasa Nishimoto, Keisuke Horiuchi, Sota Oguro, Masanori Inoue, Hideki Yashiro, Seishi Nakatsuka, Masaya Nakamura, Morio Matsumoto, Kazuhiro Chiba, Hideo Morioka
BACKGROUND: Historically, local control of recurrent sarcomas has been limited to radiotherapy when surgical re-resection is not feasible. For metastatic carcinomas to the bone or soft tissue, radiotherapy and some interventional radiology treatment along with other systemic therapies have been widely advocated due to the possibility of disseminated disease. These techniques are effective in alleviating pain and achieving local control for some tumor types, but it has not been effective for prolonged local control of most tumors...
October 13, 2016: BMC Cancer
https://www.readbyqxmd.com/read/27733205/erratum-to-surgical-spacer-placement-prior-carbon-ion-radiotherapy-cirt-an-effective-feasible-strategy-to-improve-the-treatment-for-sacral-chordoma
#15
Lorenzo Cobianchi, Andrea Peloso, Barbara Vischioni, Denis Panizza, Maria Rosaria Fiore, Piero Fossati, Viviana Vitolo, Alberto Iannalfi, Mario Ciocca, Silvia Brugnatelli, Tommaso Dominioni, Dario Bugada, Marcello Maestri, Mario Alessiani, Francesca Valvo, Roberto Orecchia, Paolo Dionigi
No abstract text is available yet for this article.
October 12, 2016: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/27729085/chordoma-dedifferentiation-after-proton-beam-therapy-a-case-report-and-review-of-the-literature
#16
Joseph Frankl, Cassi Grotepas, Baldassare Stea, G Michael Lemole, Alexander Chiu, Rihan Khan
BACKGROUND: Chordoma is a rare invasive bone tumor that may occur anywhere along the neuraxis. A total of three primary histological varieties have been identified: conventional, chondroid, and dedifferentiated. CASE PRESENTATION: We report a case of an 8-year-old white girl who presented with conventional chordoma, was treated with surgical resection and mixed proton and photon beam therapy, and had a recurrence in the resection cavity 2.5 years later with dedifferentiated morphology...
October 12, 2016: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/27722873/bayesian-pretest-probability-estimation-for-primary-malignant-bone-tumors-based-on-the-surveillance-epidemiology-and-end-results-program-seer-database
#17
Matthias Benndorf, Jakob Neubauer, Mathias Langer, Elmar Kotter
PURPOSE: In the diagnostic process of primary bone tumors, patient age, tumor localization and to a lesser extent sex affect the differential diagnosis. We therefore aim to develop a pretest probability calculator for primary malignant bone tumors based on population data taking these variables into account. METHODS: We access the SEER (Surveillance, Epidemiology and End Results Program of the National Cancer Institute, 2015 release) database and analyze data of all primary malignant bone tumors diagnosed between 1973 and 2012...
October 8, 2016: International Journal of Computer Assisted Radiology and Surgery
https://www.readbyqxmd.com/read/27721781/pudendal-neuralgia-as-the-initial-manifestation-of-infiltrative-sacrococcygeal-chordoma
#18
Sira Carrasco García de León, José Manuel Flores Barragán, Natalia Villasanti Rivas
Sacrococcygeal chordoma is a malignant tumour originating from remnants of the notochord. Chordomas are slow-growing tumours whose symptoms develop insidiously. We present the case of a 72-year-old woman with a 6-month history of genital pain radiating to the perianal area and exacerbating when she was in a sitting position. MRI and PET studies revealed a large mass in the sacrococcygeal region causing bone destruction and invasion of neurovascular structures. The immunohistochemical study of the surgical specimen determined it to be chordoma...
May 2016: Case Reports in Neurology
https://www.readbyqxmd.com/read/27712643/sacral-chordoma
#19
Ryan C Romano, Melanie C Bois, Lori A Erickson
No abstract text is available yet for this article.
October 2016: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/27696380/phase-2-study-of-dasatinib-in-patients-with-alveolar-soft-part-sarcoma-chondrosarcoma-chordoma-epithelioid-sarcoma-or-solitary-fibrous-tumor
#20
Scott M Schuetze, Vanessa Bolejack, Edwin Choy, Kristen N Ganjoo, Arthur P Staddon, Warren A Chow, Hussein A Tawbi, Brian L Samuels, Shreyaskumar R Patel, Margaret von Mehren, Gina D'Amato, Kirsten M Leu, David M Loeb, Charles A Forscher, Mohammed M Milhem, Daniel A Rushing, David R Lucas, Rashmi Chugh, Denise K Reinke, Laurence H Baker
BACKGROUND: Alveolar soft part sarcoma (ASPS), chondrosarcoma (CS), chordoma, epithelioid sarcoma, and solitary fibrous tumor (SFT) are malignant tumors that are relatively resistant to chemotherapy and for which more effective drug therapy is needed. METHODS: The 5 listed subtypes were enrolled into a single indolent sarcoma cohort in a phase 2 study of dasatinib using a Bayesian continuous monitoring rule for enrollment. The primary objective was to estimate the 6-month progression-free survival (PFS) rate according to the Choi criteria with a target of ≥50%...
October 3, 2016: Cancer
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