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https://www.readbyqxmd.com/read/28538220/identification-of-caries-risk-determinants-in-toddlers-results-of-the-gusto-birth-cohort-study
#1
C Un Lam, L W Khin, A C Kalhan, R Yee, Y S Lee, M F-F Chong, K Kwek, S M Saw, K Godfrey, Y S Chong, C-Y Hsu
The aim of this study was to identify risk determinants leading to early childhood caries (ECC) and visible plaque (VP) in toddlers. Data for mother-child pairs participating in the Growing Up in Singapore towards Healthy Outcomes (GUSTO) birth cohort were collected from pregnancy to toddlerhood. Oral examinations were performed in 543 children during their clinic visit at 24 months to detect ECC and VP. Following logistic regression, ECC and VP were jointly regressed as primary and secondary outcomes, respectively, using the bivariate probit model...
May 25, 2017: Caries Research
https://www.readbyqxmd.com/read/28535164/meat-dietary-heme-iron-and-risk-of-type-2-diabetes-the-singapore-chinese-health-study
#2
Mohammad Talaei, Ye-Li Wang, Jian-Min Yuan, An Pan, Woon-Puay Koh
We evaluated the relations of red meat, poultry, fish and shellfish, as well as heme iron intake, with risk of type 2 diabetes (T2D).The Singapore Chinese Health Study is a population-based cohort that recruited 63,257 Chinese adults aged 45-74 years from 1993 to 1998. Usual diet was evaluated by a validated 165-item semi-quantitative food-frequency questionnaire at recruitment. Physician-diagnosed T2D was self-reported during two follow-up interviews in 1999-2004 and 2006-2010. During a mean follow-up of 10...
May 23, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28533530/the-impact-of-hand-foot-and-mouth-disease-control-policies-in-singapore-a-qualitative-analysis-of-public-perceptions
#3
Karen Siegel, Alex R Cook, Hanh La
Hand foot and mouth disease (HFMD) is a widespread pediatric disease in Asia. Most cases are relatively mild and caused by Coxsackie viruses, but in epidemics caused by Enterovirus 71, severe complications can occur. In response to the deaths of dozens of children in a 1997 outbreak (Podin in BMC Public Health 6:180,1 Abubakar in Virus Res 61(1):1-9,2 WHO in3), Singapore practices childcare centre surveillance, case-isolation, and short-term closure of centres. We conducted 44 in-depth interviews with teachers, principals, and parents at four childcare centres in Singapore to better understand experiences with current control policies...
May 2017: Journal of Public Health Policy
https://www.readbyqxmd.com/read/28533235/the-tet39-determinant-and-the-msre-mphe-genes-in-acinetobacter-plasmids-are-each-part-of-discrete-modules-flanked-by-inversely-oriented-pdif-xerc-xerd-sites
#4
Grace A Blackwell, Ruth M Hall
The tet39 tetracycline resistance determinant and the macrolide resistance genes msrE and mphE were found in an 18.2 kb plasmid, pS30-1, recovered from a GC2 Acinetobacter baumannii isolate from Singapore, that conferred resistance to tetracycline and erythromycin. pS30-1 also contains mobA and mobC genes encoding MOBQ family proteins but attempts to mobilise pS30-1 utilising a co-resident conjugative repAci6 plasmid were unsuccessful. Eight pdif sites, consisting of inversely-oriented binding sites for the XerC and XerD recombinases separated by 6 bp, were detected in pS30-1...
May 22, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28528130/increased-body-mass-index-is-a-risk-factor-for-end-stage-renal-disease-in-the-chinese-singapore-population
#5
Quan-Lan Jasmine Lew, Tazeen Hasan Jafar, Mohammad Talaei, Aizhen Jin, Khuan Yew Chow, Jian-Min Yuan, Woon-Puay Koh
The relationship between body mass index (BMI) and end-stage renal disease (ESRD) is confounded by co-morbidities associated with both conditions. Furthermore, the association at low range BMI is controversial. We studied this association in the Singapore Chinese Health Study, a population-based prospective cohort that recruited Singaporean Chinese men and women 45-74 years of age from 1993 to 1998. Self-reported weight, height, lifestyle factors, usual diet, and medical history were collected via an interviewer-administered questionnaire...
May 18, 2017: Kidney International
https://www.readbyqxmd.com/read/28527892/outbreak-of-zika-virus-infection-in-singapore-an-epidemiological-entomological-virological-and-clinical-analysis
#6
(no author information available yet)
BACKGROUND: An outbreak of Zika virus infection was detected in Singapore in August, 2016. We report the first comprehensive analysis of a national response to an outbreak of Zika virus infection in Asia. METHODS: In the first phase of the outbreak, patients with suspected Zika virus infection were isolated in two national referral hospitals until their serum tested negative for the virus. Enhanced vector control and community engagement measures were deployed in disease clusters, including stepped-up mosquito larvicide and adulticide use, community participation in source reduction (destruction of mosquito breeding sites), and work with the local media to promote awareness of the outbreak...
May 17, 2017: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/28527891/zika-virus-in-singapore-unanswered-questions
#7
Didier Musso, Marion C Lanteri
No abstract text is available yet for this article.
May 17, 2017: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/28525619/epidemiology-and-clinical-characteristics-of-invasive-mould-infections-a-multicenter-retrospective-analysis-in-five-asian-countries
#8
R Porpon, Y C Chen, A Chakrabarti, R Y Li, R M Shivaprakash, J Yu, H C Kung, S Watcharananan, A L Tan, S E Saffari, B H Tan
Formal, large-scale, multicenter studies of invasive mould infection (IMI) in Asia are rare. This 1-year, retrospective study was designed to assess the incidence and clinical determinants of IMI in centers in five countries (Thailand, Taiwan, Singapore, China, India). Patients treated in a single year (2012) were identified through discharge diagnoses, microbiology, and histopathology logs, and entered based on published definitions of IMI. A total of 155 cases were included (median age 54 years; 47.7% male)...
May 19, 2017: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
https://www.readbyqxmd.com/read/28520939/dietary-intake-of-antioxidant-vitamins-and-carotenoids-and-risk-of-developing-active-tuberculosis-in-a-prospective-population-based-cohort
#9
Avril Z Soh, Cynthia B E Chee, Yee-Tang Wang, Jian-Min Yuan, Woon-Puay Koh
Antioxidants may protect against oxidative stress, which is associated with tuberculosis disease. However, direct evidence for the protective association between dietary antioxidants and tuberculosis incidence in humans has been lacking. The relation between intake of antioxidant vitamins (A, C, D, E) and individual carotenoids (α-carotene, β-carotene, β-cryptoxanthin, lycopene, lutein) and tuberculosis incidence was examined in the Singapore Chinese Health Study, a prospective cohort of 63,257 adults 45-74 years old enrolled during 1993-1998...
May 18, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28514505/the-trajectory-of-experience-of-critical-care-nurses-in-providing-end-of-life-care-a-qualitative-descriptive-study
#10
Keh Kiong Ong, Kit Cheng Ting, Yeow Leng Chow
AIM AND OBJECTIVES: To understand the perceptions of critical care nurses towards providing end-of-life care. BACKGROUND: There has been an increasing interest in end-of-life care in the critical care setting. In Singapore, approximately half of deaths in the hospital occur during or after critical care. While nurses are well-positioned to provide end-of-life care to patients and their family members, they faced barriers to providing end-of-life care. Also, providing end-of-life care has profound positive and negative psychological effects on nurses, with the latter being more prominent...
May 17, 2017: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/28511040/removal-of-selected-ppcps-edcs-and-antibiotic-resistance-genes-in-landfill-leachate-by-a-full-scale-constructed-wetlands-system
#11
Xinzhu Yi, Ngoc Han Tran, Tingru Yin, Yiliang He, Karina Yew-Hoong Gin
Landfill leachate could be a significant source of emerging contaminants (ECs) and antibiotic resistance genes (ARGs) into the environment. This study provides the first information on the occurrence of selected ECs and ARGs in raw leachate from 16-year old closed landfill site in Singapore. Among the investigated ECs, acetaminophen (ACT), bisphenol A (BPA), clofibric acid (CA), caffeine (CF), crotamiton (CTMT), diclofenac (DCF), N,N-diethyl-m-toluamide (DEET), gemfibrozil (GFZ), lincomycin (LIN), salicylic acid (SA), and sulfamethazine (SMZ) were the most frequently detected compounds in raw landfill leachate...
May 8, 2017: Water Research
https://www.readbyqxmd.com/read/28508411/the-relationship-between-symptom-prevalence-body-image-and-quality-of-life-in-asian-gynecologic-cancer-patients
#12
Irene Teo, Yin Bun Cheung, Yong Kuei Lim, Namuduri Rama Padmavathi, Victoria Long, Komal Tewani
OBJECTIVE: Gynecologic cancer is associated with long-term effects that can be both physical and emotional. We examined symptom prevalence and body image disturbance in patients with gynecologic cancer, and their association with quality of life. Predictors of clinically-relevant body image disturbance were examined. METHODS: A sample of patients in Singapore (n = 104) was assessed for symptom prevalence, quality of life, and body image dissatisfaction. Clinical factors were extracted from medical records...
May 15, 2017: Psycho-oncology
https://www.readbyqxmd.com/read/28503699/eating-psychopathology-and-psychosocial-impairment-in-patients-treated-at-a-singapore-eating-disorders-treatment-programme
#13
Kah Wee Ng, Angeline Kuek, Huei Yen Lee
INTRODUCTION: There is limited data on the psychopathology of eating disorders in Singapore. This study: (a) describes levels of eating psychopathology and psychosocial impairment among individuals diagnosed with eating disorders at our hospital; and (b) compares the related psychopathology of these patients. METHODS: Between 1 August 2010 and 31 July 2012, 257 individuals who met the diagnostic criteria for eating disorders completed the Eating Disorder Examination Questionnaire (EDE-Q) and Clinical Impairment Assessment questionnaire (CIA)...
May 15, 2017: Singapore Medical Journal
https://www.readbyqxmd.com/read/28503698/breast-reconstruction-rate-and-profile-in-a-singapore-patient-population-a-national-university-hospital-experience
#14
Nadia Sim, Sharon Soh, Chuan Han Ang, Chor Hoong Hing, Han Jing Lee, Vigneswaran Nallathamby, Yan Lin Yap, Wei Chen Ong, Thiam Chye Lim, Jane Lim
INTRODUCTION: Breast reconstruction is an integral part of breast cancer management, with the aim of restoring a breast to its natural form. There is increasing awareness among women that it is a safe procedure and its benefits extend beyond aesthetics. Our aim was to establish the rate of breast reconstruction and provide an overview of the patients who underwent breast reconstruction at National University Hospital (NUH), Singapore. METHODS: We evaluated factors, such as ethnicity, age, time and type of implant, for their impact on a patient's decision to proceed with breast reconstruction...
May 15, 2017: Singapore Medical Journal
https://www.readbyqxmd.com/read/28501376/six-year-incidence-of-age-related-macular-degeneration-in-asian-malays-the-singapore-malay-eye-study
#15
Chui Ming Gemmy Cheung, Peng Guan Ong, Kumari Neelam, Pok Chien Tan, Yuan Shi, Paul Mitchell, Jie Jin Wang, Charumathi Sabanayagam, Ching-Yu Cheng, Tien Yin Wong
PURPOSE: To determine the 6-year incidence of early and late age-related macular degeneration (AMD) in a Singaporean Malay population and to validate the Age-Related Eye Disease Study (AREDS) simplified severity scale in Asians. DESIGN: Prospective, population cohort study. PARTICIPANTS: The Singapore Malay Eye Study baseline participants (age, ≥40 years; 2006-2008) were followed up in 2011 through 2013, and 1901 of 3280 of eligible participants (72...
May 10, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28500747/investigating-biogeographic-boundaries-of-the-sunda-shelf-a-phylogenetic-analysis-of-two-island-populations-of-macaca-fascicularis
#16
A R Klegarth, S A Sanders, A D Gloss, K E Lane-deGraaf, L Jones-Engel, A Fuentes, H Hollocher
OBJECTIVES: Cyclical submergence and re-emergence of the Sunda Shelf throughout the Pleistocene served as a dynamic biogeographic landscape, across which long-tailed macaques (Macaca fascicularis) have migrated and evolved. Here, we tested the integrity of the previously reported continental-insular haplotype divide reported among Y and mitochondrial DNA lineages across multiple studies. MATERIALS AND METHODS: The continental-insular haplotype divide was tested by heavily sampling wild macaques from two important biogeographic regions within Sundaland: (1) Singapore, the southernmost tip of continental Asia and (2) Bali, Indonesia, the southeastern edge of the Indonesian archipelago, immediately west of Wallace's line...
May 13, 2017: American Journal of Physical Anthropology
https://www.readbyqxmd.com/read/28493905/melioidosis-clinical-impact-and-public-health-threat-in-the-tropics
#17
REVIEW
Ramar Perumal Samy, Bradley G Stiles, Gautam Sethi, Lina H K Lim
This review briefly summarizes the geographical distribution and clinical impact of melioidosis, especially in the tropics. Burkholderia pseudomallei (a gram-negative bacterium) is the major causative agent for melioidosis, which is prevalent in Singapore, Malaysia, Thailand, Vietnam, and Northern Australia. Melioidosis patients are increasingly being recognized in other parts of the world. The bacteria are intrinsically resistant to many antimicrobial agents, but prolonged treatment, especially with combinations of antibiotics, may be effective...
May 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28492872/urinary-isoprostane-levels-and-age-related-macular-degeneration
#18
Charumathi Sabanayagam, Weng Kit Lye, Andrzej Januszewski, Riswana Banu Binte Mohammed Abdul, Gemmy Chui Ming Cheung, Neelam Kumari, Tien Y Wong, Ching-Yu Cheng, Ecosse Lamoureux
Purpose: Oxidative stress, characterized by an excessive production of reactive oxygen intermediates has been suggested to play a role in the pathogenesis of age-related macular degeneration (AMD). We examined the association of urinary F2-isoprostanes (F2-IsoPs), a marker of lipid peroxidation and the most reliable marker of oxidative damage with AMD. Methods: We included 238 adults with AMD and 390 age- and sex-matched controls without AMD who participated in a population-based cross-sectional study in Singapore (Singapore Chinese Eye Study, 2009-2011)...
May 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28492404/trend-and-outcomes-of-video-laryngoscope-use-across-picus
#19
Jocelyn R Grunwell, Pradip P Kamat, Michael Miksa, Ashwin Krishna, Karen Walson, Dennis Simon, Conrad Krawiec, Ryan Breuer, Jan Hau Lee, Eleanor Gradidge, Keiko Tarquinio, Asha Shenoi, Justine Shults, Vinay Nadkarni, Akira Nishisaki
OBJECTIVE: Video (indirect) laryngoscopy is used as a primary tracheal intubation device for difficult airways in emergency departments and in adult ICUs. The use and outcomes of video laryngoscopy compared with direct laryngoscopy has not been quantified in PICUs or cardiac ICUs. DESIGN: Retrospective review of prospectively collected observational data from a multicenter tracheal intubation database (National Emergency Airway Registry for Children) from July 2010 to June 2015...
May 10, 2017: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/28491891/a-report-of-adult-human-adenovirus-infections-in-a-tertiary-hospital
#20
Shirin Kalimuddin, Yvonne F Z Chan, Ian Q Wu, Qiao Li Tan, Kavitha G Murthee, Ban Hock Tan, Lynette L E Oon, Yong Yang, Raymond T P Lin, Udayan Joseph, October M Sessions, Gavin J D Smith, Eng Eong Ooi, Jenny G H Low
We describe a review of human adenovirus (HAdV) infections occurring among adults in a tertiary hospital in Singapore from February to May 2013. A similar increase in cases was observed among children and military personnel during the same time period. The majority of isolates were identified as HAdV-7, likely an emerging pathogen in Asia.
2017: Open Forum Infectious Diseases
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