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https://www.readbyqxmd.com/read/29331952/inter-relationship-between-ocular-perfusion-pressure-blood-pressure-intraocular-pressure-profiles-and-primary-open-angle-glaucoma-the-singapore-epidemiology-of-eye-diseases-study
#1
Yih-Chung Tham, Sing-Hui Lim, Preeti Gupta, Tin Aung, Tien Y Wong, Ching-Yu Cheng
OBJECTIVE: To elucidate the inter-relationship between ocular perfusion pressure (OPP), blood pressure (BP), intraocular pressure (IOP) profiles and primary open-angle glaucoma (POAG) in a multiethnic Asian population. METHODS: Participants were recruited from the Singapore Epidemiology of Eye Diseases Study and underwent standardised ocular and systemic examinations. POAG was defined according to the International Society for Geographical and Epidemiological Ophthalmology criteria...
January 13, 2018: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/29328847/an-anaesthesia-perspective-on-carotid-body-tumour-cbt-excision-a-twenty-year-case-series-at-the-singapore-general-hospital
#2
Deanna Wj Ng, Chris I Yam, Loong T Wong, Darren Lk Koh
Carotid body tumours (CBT) are extremely rare neoplasms that arise from chemoreceptor cells at the bifurcation of the carotid artery. This rarity poses a challenge for the anaesthetist when dealing with surgeries for the removal of CBT. Reports of associated perioperative morbidity range from twenty to forty percent. This paper reviews the perioperative anaesthetic management of CBT patients and challenges in our institution's 20 year experience on 13 surgical CBT resections.
October 2017: Journal of Perioperative Practice
https://www.readbyqxmd.com/read/29323125/author-correction-hot-carrier-cooling-mechanisms-in-halide-perovskites
#3
Jianhui Fu, Qiang Xu, Guifang Han, Bo Wu, Cheng Hon Alfred Huan, Meng Lee Leek, Tze Chien Sum
The original version of this Article omitted an affiliation of Cheng Hon Alfred Huan: 'Institute of Materials Research and Engineering (IMRE), A*STAR, 2 Fusionopolis Way, Innovis #08-03 138634, Singapore'.This has now been corrected in both the PDF and HTML versions of the article.
January 11, 2018: Nature Communications
https://www.readbyqxmd.com/read/29321603/plasma-adiponectin-levels-and-type-2-diabetes-risk-a-nested-case-control-study-in-a-chinese-population-and-an-updated-meta-analysis
#4
Yeli Wang, Rui-Wei Meng, Setor K Kunutsor, Rajiv Chowdhury, Jian-Min Yuan, Woon-Puay Koh, An Pan
Results from previous prospective studies assessing the relation between adiponectin and type 2 diabetes (T2D) were not entirely consistent, and evidence in Chinese population is scarce. Moreover, the last meta-analysis did not examine the impact of metabolic variables on the adiponectin-T2D association. Therefore, we prospectively evaluated the adiponectin-T2D association among 571 T2D cases and 571 age-sex-matched controls nested within the Singapore Chinese Health Study (SCHS). Furthermore, we conducted an updated meta-analysis by searching prospective studies on Pubmed till September 2016...
January 10, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29321127/effectiveness-of-a-technology-based-supportive-educational-parenting-program-on-parental-outcomes-in-singapore-protocol-for-a-randomized-controlled-trial
#5
Shefaly Shorey, Yvonne Peng Mei Ng, An Ling Siew, Joanne Yoong, Evalotte Mörelius
BACKGROUND: Supportive educational programs during the perinatal period are scarce in Singapore. There is no continuity of care available in terms of support from community care nurses in Singapore. Parents are left on their own most of the time, which results in a stressful transition to parenthood. There is a need for easily accessible technology-based educational programs that can support parents during this crucial perinatal period. OBJECTIVE: The aim of this study was to describe the study protocol of a randomized controlled trial on a technology-based supportive educational parenting program...
January 10, 2018: JMIR Research Protocols
https://www.readbyqxmd.com/read/29318605/leukocyte-telomere-length-in-relation-to-risk-of-lung-adenocarcinoma-incidence-findings-from-the-singapore-chinese-health-study
#6
Jian-Min Yuan, Kenneth B Beckman, Renwei Wang, Caroline Bull, Jennifer Adams-Haduch, Joyce Y Huang, Aizhen Jin, Patricia Opresko, Anne B Newman, Yun-Ling Zheng, Michael Fenech, Woon-Puay Koh
Telomeres are crucial in the maintenance of chromosome integrity and genomic stability. Critically short telomeres can trigger programmed cell death while cells with longer telomeres may have increased likelihood of replicative errors, resulting in genetic mutations and chromosomal alterations, and ultimately promoting oncogenesis. Data on telomere length and lung cancer risk from large prospective cohort studies are spare. Relative telomere length in peripheral blood leukocytes was quantified using a validated monochrome multiplex quantitative polymerase chain reaction (qPCR) method in 26,540 participants of the Singapore Chinese Health Study...
January 10, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29318089/falls-cognitive-function-and-balance-profiles-of-singapore-community-dwelling-elderly-individuals-key-risk-factors
#7
Mei Teng Woo, Keith Davids, Jarmo Liukkonen, Jia Yi Chow, Timo Jaakkola
Objective: This study compared occurrence of falls, cognitive function, and balance profiles across participants in elderly age categories, investigating associations between the 3 aspects in a sample of Singapore's elderly population. Method: Community-dwelling elderly individuals (N = 385) were randomly recruited and grouped into "young-old (65-74 years)," "medium-old (75-84 years)," and "oldest-old (above 85 years)" groups. The Fallproof Health and Activity questionnaire, adapted Mini-Mental State Examination (MMSE), and Berg Balance Scale (BBS) tests were used to survey information related to falls, cognition, and balance profiles...
December 2017: Geriatric Orthopaedic Surgery & Rehabilitation
https://www.readbyqxmd.com/read/29316293/estimating-radiotherapy-demands-in-south-east-asia-countries-in-2025-and-2035-using-evidence-based-optimal-radiotherapy-fractions
#8
Noorazrul Yahya, Nurhaziqah Roslan
BACKGROUND AND PURPOSE: As about 50% of cancer patients may require radiotherapy, the demand of radiotherapy as the main treatment to treat cancer is likely to rise due to rising cancer incidence. This study aims to quantify the radiotherapy demand in countries in Southeast Asia (SEA) in 2025 and 2035 using evidence-based optimal radiotherapy fractions. MATERIALS AND METHODS: SEA country-specific cancer incidence by tumor site for 2015, 2025 and 2035 was extracted from the GLOBOCAN database...
January 8, 2018: Asia-Pacific Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29311490/severe-visceral-pentastomiasis-in-an-oriental-small-clawed-otter-with-functional-thyroid-carcinoma
#9
Chia-Da Hsu, Yaoprapa Mathura
In January 2016, a 20-year-old female oriental small-clawed otter (Aonyx cinereus) from Night Safari in Singapore was euthanized and diagnosed with a thyroid gland carcinoma. Postmortem examination and histology also revealed metastasis to the regional lymph nodes and severe visceral pentastomiasis. Grossly, the lymph nodes were infested, and encapsulation was observed on the visceral serosal surface. Histopathologically, the lymph nodes were encysted by a thick fibrous connective capsule with minimal inflammatory response...
January 1, 2018: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/29310965/evaluation-of-primary-angle-closure-glaucoma-susceptibility-loci-in-patients-with-early-stages-of-angle-closure-disease
#10
Monisha E Nongpiur, Ching-Yu Cheng, Roopam Duvesh, Saravanan Vijayan, Mani Baskaran, Chiea-Chuen Khor, John Allen, Srinivasan Kavitha, Rengaraj Venkatesh, David Goh, Rahat Husain, Pui Yi Boey, Desmond Quek, Ching Lin Ho, Tina T Wong, Shamira Perera, Tien Yin Wong, Subbiah R Krishnadas, Periasamy Sundaresan, Tin Aung, Eranga N Vithana
PURPOSE: To investigate whether newly identified genetic loci for primary angle-closure glaucoma (PACG) are associated with early stage angle-closure disease defined as primary angle closure suspect (PACS). DESIGN: Case-control study. PARTICIPANTS: A total of 1397 PACS patients and 943 controls of Chinese ethnicity from Singapore and 604 PACS patients and 287 controls of Indian ethnicity. METHODS: The 8 PACG single nucleotide polymorphisms (SNPs; rs11024102 at PLEKHA7, rs3753841 at COL11A1, rs1015213 located between PCMTD1 and ST18 son chromosome 8q, rs3816415 at EPDR1, rs1258267 at CHAT, rs736893 at GLIS3, rs7494379 at FERMT2, and rs3739821 mapping in between DPM2 and FAM102A) were genotyped by Taqman assays...
January 5, 2018: Ophthalmology
https://www.readbyqxmd.com/read/29304787/factors-associated-with-prolonged-length-of-stay-for-elective-hepatobiliary-and-neurosurgery-patients-a-retrospective-medical-record-review
#11
Siu Yin Lee, Soo-Hoon Lee, Jenny H H Tan, Howard S L Foo, Phillip H Phan, Alfred W C Kow, Sein Lwin, Penelope M Y Seah, Siti Zubaidah Mordiffi
BACKGROUND: Patients with prolonged length of hospital stay (LOS) not only increase their risks of nosocomial infections but also deny other patients access to inpatient care. Hepatobiliary (HPB) malignancies have some of highest incidences in East and Southeast Asia and the management of patients undergoing HPB surgeries have yet to be standardized. With improved neurosurgery techniques for intracranial aneurysms and tumors, neurosurgeries (NS) can be expected to increase. Elective surgeries account for far more operations than emergencies surgeries...
January 5, 2018: BMC Health Services Research
https://www.readbyqxmd.com/read/29304553/hearing-impairment-and-hearing-aid-usage-in-singapore
#12
Eu Chin Ho, HanYu Zhang, Warren Ming Wu Ong, KeXin Li, Yen Tze Eileen Bei, Satya Vijay Reddy Medapati, Aruni Seneviratna
OBJECTIVE: To examine the epidemiological and audiological profile, pattern of hearing aid (HA) fitting and usage among HA users in Singapore. DESIGN: Retrospective cross-sectional study. STUDY SAMPLE: Cohort of 1068 subjects issued with HAs at a tertiary hospital between 2001 and 2013. RESULTS: Mean age was 70 years with 50.8% male. Mean hearing loss (HL) was 63.1 dB and 69.5% had at least moderate-severe HL. Sensorineural HL was present in 66...
January 5, 2018: International Journal of Audiology
https://www.readbyqxmd.com/read/29301903/draft-genome-sequence-of-singapore-klebsiella-pneumoniae-subsp-pneumoniae-isolate-ds32358_14-which-contains-the-carbapenemase-gene-blavim-1
#13
Tse H Koh, Nurdyana Binte Abdul Rahman, Jeanette W P Teo, My-Van La, Balamurugan Periaswamy, Swaine L Chen
We sequenced the first blaVIM-1-positive Klebsiella pneumoniae strain isolated in Singapore. The isolate belongs to multilocus sequence type 2542 (ST2542), and blaVIM-1 was the first gene in an integron that also contained aacA4, aphA15, aadA1, catB2, qacEdelta1, and sul1.
January 4, 2018: Genome Announcements
https://www.readbyqxmd.com/read/29301119/cause-and-clinical-presentation-of-anaphylaxis-in-singapore-from-infancy-to-old-age
#14
Si Hui Goh, Jian Yi Soh, Wenyin Loh, Khai Pin Lee, Sze Chin Tan, Wei Jian Kenneth Heng, Irwani Ibrahim, Bee Wah Lee, Wen Chin Chiang
BACKGROUND: The study objective was to compare age-related differences in the cause and clinical presentation of anaphylaxis. METHODS: We conducted a prospective study of patients visiting the emergency department for anaphylaxis. Data were collected from 3 emergency departments from 1 April 2014 to 31 December 2015. Patient electronic records with the diagnoses of allergy, angioedema, urticaria, and anaphylaxis (ICD-9 codes 9953, 9951, 7080, 9950, 7089) were screened and cases fulfilling World Allergy Organisation criteria for anaphylaxis were included...
January 5, 2018: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/29299282/inducing-broadcast-coral-spawning-ex-situ-closed-system-mesocosm-design-and-husbandry-protocol
#15
Jamie Craggs, James R Guest, Michelle Davis, Jeremy Simmons, Ehsan Dashti, Michael Sweet
For many corals, the timing of broadcast spawning correlates strongly with a number of environmental signals (seasonal temperature, lunar, and diel cycles). Robust experimental studies examining the role of these putative cues in triggering spawning have been lacking until recently because it has not been possible to predictably induce spawning in fully closed artificial mesocosms. Here, we present a closed system mesocosm aquarium design that utilizes microprocessor technology to accurately replicate environmental conditions, including photoperiod, seasonal insolation, lunar cycles, and seasonal temperature from Singapore and the Great Barrier Reef (GBR), Australia...
December 2017: Ecology and Evolution
https://www.readbyqxmd.com/read/29298714/paediatric-palliative-care-improves-patient-outcomes-and-reduces-healthcare-costs-evaluation-of-a-home-based-program
#16
P H Chong, J A De Castro Molina, K Teo, W S Tan
BACKGROUND: Around the world, different models of paediatric palliative care have responded to the unique needs of children with life shortening conditions. However, research confirming their utility and impact is still lacking. This study compared patient-related outcomes and healthcare expenditures between those who received home-based paediatric palliative care and standard care. The quality of life and caregiver burden for patients receiving home-based paediatric palliative care were also tracked over the first year of enrolment to evaluate the service's longitudinal impact...
January 3, 2018: BMC Palliative Care
https://www.readbyqxmd.com/read/29297089/cricoid-ridge-ossification-mimicking-ingested-fish-bone-on-plain-radiography-prevalence-in-singapore
#17
Sheldon Jin Keat Ng, Joseph King Tak Lee, Yee Liang Thian
INTRODUCTION: Ossification of the cricoid ridge mimicking impacted upper aerodigestive tract fish bone has been described in several case reports. We performed this study to determine the prevalence of such ossification in an adult population from Singapore and to identify specific imaging features that may be used as aid in differentiating patients with cricoid ridge ossification from those having an upper aerodigestive tract impacted fish bone. METHODS: We retrospectively evaluated 442 lateral neck radiographs of patients aged 16 years and above that were performed in the adult emergency department at the National University Hospital, Singapore, during the four-month period between 1 September 2014 and 31 December 2014...
January 3, 2018: Singapore Medical Journal
https://www.readbyqxmd.com/read/29297088/changes-in-operative-experience-after-the-introduction-of-residency-an-objective-comparison-of-surgical-and-endoscopic-volumes
#18
Kherru Sarah Sim, Jin Yao Teo, Peng Chung Cheow
INTRODUCTION: The SingHealth Residency General Surgery Programme replaced the basic and advanced specialist training (AST) system in Singapore in 2010. The relative merits of both systems continue to be debated, especially concerning the operational readiness of graduating residents. We set out to compare the operative and endoscopic volumes of graduates from the AST system with those from the first graduating batch of the residency programme during their registrar (or equivalent) years, as a reflection of procedural experience gained during traineeship...
January 3, 2018: Singapore Medical Journal
https://www.readbyqxmd.com/read/29297087/biobrane-dressing-for-paediatric-burns-in-singapore-a-retrospective-review
#19
Cong Fan, Chong Han Pek, Yong Chen Por, Gale Jue Shuang Lim
INTRODUCTION: The ideal burn dressing for children should aim to alleviate pain, decrease length of hospital stay and minimise complications, such as conversion and infection. The current literature is still inconclusive with regard to the gold standard burn dressing for the paediatric population. METHODS: We retrospectively reviewed children with superficial partial thickness burns admitted to our paediatric burn unit from January 2014 to April 2015. A total of 30 patients were included in our study, of which 13 had Biobrane dressing...
January 3, 2018: Singapore Medical Journal
https://www.readbyqxmd.com/read/29297086/juronghealth-research-symposium-2017-to-equip-enable-enhance-singapore-5-october-2017-proceedings-and-abstracts
#20
(no author information available yet)
No abstract text is available yet for this article.
December 2017: Singapore Medical Journal
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