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JOURNAL ARTICLE
Emma D Johnson, James D Chalmers
No abstract text is available yet for this article.
January 22, 2024: Lancet Respiratory Medicine
#22
JOURNAL ARTICLE
Eva Polverino, Anthony De Soyza, Katerina Dimakou, Letizia Traversi, Apostolos Bossios, Megan L Crichton, Felix C Ringshausen, Montserrat Vendrell, Pierre-Régis Burgel, Charles S Haworth, Michael R Loebinger, Natalie Lorent, Isabell Pink, Melissa McDonnell, Sabina Skrgat, Luis M Carro, Oriol Sibila, Menno van der Eerden, Paula Kauppi, Amelia Shoemark, Adelina Amorim, Jeremy S Brown, John R Hurst, Marc Miravitlles, Rosario Menendez, Antoni Torres, Tobias Welte, Francesco Blasi, Josje Altenburg, Michal Shteinberg, Wim Boersma, Stuart J Elborn, Pieter C Goeminne, Stefano Aliberti, James D Chalmers
RATIONALE AND OBJECTIVE: Bronchiectasis and COPD are associated conditions but misdiagnosis is believed to be common. A recently published international consensus definition of bronchiectasis (BE) and COPD association: The ROSE criteria (radiological bronchiectasis(R), obstruction: FEV1/FVC ratio<0.7 (O), symptoms (S) and exposure:≥10 pack year smoking (E) allows objective diagnosis of the BE-COPD association. METHODS: Analysis of the EMBARC registry, a prospective observational study of patients with CT confirmed bronchiectasis from 28 countries...
January 25, 2024: American Journal of Respiratory and Critical Care Medicine
#23
JOURNAL ARTICLE
Micheál Mac Aogáin, Fransiskus Xaverius Ivan, Tavleen Kaur Jaggi, Hollian Richardson, Amelia Shoemark, Jayanth Kumar Narayana, Alison J Dicker, Mariko Siyue Koh, Ken Cheah Hooi Lee, Ong Thun How, Mau Ern Poh, Ka Kiat Chin, Albert Lim Yick Hou, Puah Ser Hon, Teck Boon Low, John Arputhan Abisheganaden, Katerina Dimakou, Antonia Digalaki, Chrysavgi Kosti, Anna Gkousiou, Philip M Hansbro, Francesco Blasi, Stefano Aliberti, James D Chalmers, Sanjay H Chotirmall
INTRODUCTION: Application of whole-genome shotgun metagenomics to the airway microbiome in bronchiectasis highlights a diverse pool of antimicrobial resistance genes: the 'resistome', the clinical significance of which remains unclear. METHODS: Individuals with bronchiectasis were prospectively recruited into cross-sectional and longitudinal cohorts (n=280) including the international multicentre cross-sectional Cohort of Asian and Matched European Bronchiectasis 2 study (CAMEB 2; n=251) and two independent cohorts, one describing patients experiencing acute exacerbation and a further cohort of patients undergoing P...
January 25, 2024: American Journal of Respiratory and Critical Care Medicine
#24
JOURNAL ARTICLE
Markus Scholz, Katrin Horn, Janne Pott, Matthias Wuttke, Andreas Kühnapfel, M Kamal Nasr, Holger Kirsten, Yong Li, Anselm Hoppmann, Mathias Gorski, Sahar Ghasemi, Man Li, Adrienne Tin, Jin-Fang Chai, Massimiliano Cocca, Judy Wang, Teresa Nutile, Masato Akiyama, Bjørn Olav Åsvold, Nisha Bansal, Mary L Biggs, Thibaud Boutin, Hermann Brenner, Ben Brumpton, Ralph Burkhardt, Jianwen Cai, Archie Campbell, Harry Campbell, John Chalmers, Daniel I Chasman, Miao Ling Chee, Miao Li Chee, Xu Chen, Ching-Yu Cheng, Renata Cifkova, Martha Daviglus, Graciela Delgado, Katalin Dittrich, Todd L Edwards, Karlhans Endlich, J Michael Gaziano, Ayush Giri, Franco Giulianini, Scott D Gordon, Daniel F Gudbjartsson, Stein Hallan, Pavel Hamet, Catharina A Hartman, Caroline Hayward, Iris M Heid, Jacklyn N Hellwege, Bernd Holleczek, Hilma Holm, Nina Hutri-Kähönen, Kristian Hveem, Berend Isermann, Jost B Jonas, Peter K Joshi, Yoichiro Kamatani, Masahiro Kanai, Mika Kastarinen, Chiea Chuen Khor, Wieland Kiess, Marcus E Kleber, Antje Körner, Peter Kovacs, Alena Krajcoviechova, Holly Kramer, Bernhard K Krämer, Mikko Kuokkanen, Mika Kähönen, Leslie A Lange, James P Lash, Terho Lehtimäki, Hengtong Li, Bridget M Lin, Jianjun Liu, Markus Loeffler, Leo-Pekka Lyytikäinen, Patrik K E Magnusson, Nicholas G Martin, Koichi Matsuda, Yuri Milaneschi, Pashupati P Mishra, Nina Mononen, Grant W Montgomery, Dennis O Mook-Kanamori, Josyf C Mychaleckyj, Winfried März, Matthias Nauck, Kjell Nikus, Ilja M Nolte, Raymond Noordam, Yukinori Okada, Isleifur Olafsson, Albertine J Oldehinkel, Brenda W J H Penninx, Markus Perola, Nicola Pirastu, Ozren Polasek, David J Porteous, Tanja Poulain, Bruce M Psaty, Ton J Rabelink, Laura M Raffield, Olli T Raitakari, Humaira Rasheed, Dermot F Reilly, Kenneth M Rice, Anne Richmond, Paul M Ridker, Jerome I Rotter, Igor Rudan, Charumathi Sabanayagam, Veikko Salomaa, Neil Schneiderman, Ben Schöttker, Mario Sims, Harold Snieder, Klaus J Stark, Kari Stefansson, Hannah Stocker, Michael Stumvoll, Patrick Sulem, Gardar Sveinbjornsson, Per O Svensson, E-Shyong Tai, Kent D Taylor, Bamidele O Tayo, Andrej Teren, Yih-Chung Tham, Joachim Thiery, Chris H L Thio, Laurent F Thomas, Johanne Tremblay, Anke Tönjes, Peter J van der Most, Veronique Vitart, Uwe Völker, Ya Xing Wang, Chaolong Wang, Wen Bin Wei, John B Whitfield, Sarah H Wild, James F Wilson, Thomas W Winkler, Tien-Yin Wong, Mark Woodward, Xueling Sim, Audrey Y Chu, Mary F Feitosa, Unnur Thorsteinsdottir, Adriana M Hung, Alexander Teumer, Nora Franceschini, Afshin Parsa, Anna Köttgen, Pascal Schlosser, Cristian Pattaro
X-chromosomal genetic variants are understudied but can yield valuable insights into sexually dimorphic human traits and diseases. We performed a sex-stratified cross-ancestry X-chromosome-wide association meta-analysis of seven kidney-related traits (n = 908,697), identifying 23 loci genome-wide significantly associated with two of the traits: 7 for uric acid and 16 for estimated glomerular filtration rate (eGFR), including four novel eGFR loci containing the functionally plausible prioritized genes ACSL4, CLDN2, TSPAN6 and the female-specific DRP2...
January 18, 2024: Nature Communications
#25
JOURNAL ARTICLE
Post-acute COVID-19 neuropsychiatric symptoms are not associated with ongoing nervous system injury.
Maxime Taquet, Zuzanna Skorniewska, Henrik Zetterberg, John R Geddes, Catherine J Mummery, James D Chalmers, Ling-Pei Ho, Alex Horsley, Michael Marks, Krisnah Poinasamy, Betty Raman, Olivia C Leavy, Matthew Richardson, Omer Elneima, Hamish J C McAuley, Aarti Shikotra, Amisha Singapuri, Marco Sereno, Ruth M Saunders, Victoria Claire Harris, Linzy Houchen-Wolloff, Parisa Mansoori, Neil J Greening, Ewen M Harrison, Annemarie B Docherty, Nazir I Lone, Jennifer Quint, William Greenhalf, Louise V Wain, Christopher E Brightling, Rachael E Evans, Paul J Harrison, Ivan Koychev
A proportion of patients infected with severe acute respiratory syndrome coronavirus 2 experience a range of neuropsychiatric symptoms months after infection, including cognitive deficits, depression and anxiety. The mechanisms underpinning such symptoms remain elusive. Recent research has demonstrated that nervous system injury can occur during COVID-19. Whether ongoing neural injury in the months after COVID-19 accounts for the ongoing or emergent neuropsychiatric symptoms is unclear. Within a large prospective cohort study of adult survivors who were hospitalized for severe acute respiratory syndrome coronavirus 2 infection, we analysed plasma markers of nervous system injury and astrocytic activation, measured 6 months post-infection: neurofilament light, glial fibrillary acidic protein and total tau protein...
2024: Brain communications
#26
JOURNAL ARTICLE
Kerri Devine, Clark D Russell, Giovanny R Blanco, Brian R Walker, Natalie Z M Homer, Scott G Denham, Joanna P Simpson, Olivia C Leavy, Omer Elneima, Hamish J C McAuley, Aarti Shikotra, Amisha Singapuri, Marco Sereno, Ruth M Saunders, Victoria C Harris, Linzy Houchen-Wolloff, Neil J Greening, Nazir I Lone, Mathew Thorpe, William Greenhalf, James D Chalmers, Ling-Pei Ho, Alex Horsley, Michael Marks, Betty Raman, Shona C Moore, Jake Dunning, Malcolm G Semple, Ruth Andrew, Louise V Wain, Rachael A Evans, Christopher E Brightling, John Kenneth Baillie, Rebecca M Reynolds
OBJECTIVE: Endocrine systems are disrupted in acute illness, and symptoms reported following coronavirus disease 2019 (COVID-19) are similar to those found with clinical hormone deficiencies. We hypothesised that people with severe acute COVID-19 and with post-COVID symptoms have glucocorticoid and sex hormone deficiencies. DESIGN/PATIENTS: Samples were obtained for analysis from two UK multicentre cohorts during hospitalisation with COVID-19 (International Severe Acute Respiratory Infection Consortium/World Health Organisation [WHO] Clinical Characterization Protocol for Severe Emerging Infections in the UK study), and at follow-up 5 months after hospitalisation (Post-hospitalisation COVID-19 study)...
January 17, 2024: Clinical Endocrinology
#27
JOURNAL ARTICLE
Michal Shteinberg, Arietta Spinou, Pieter Goeminne, Megan Crichton, Charles Haworth, James D Chalmers
Specialists caring for people with bronchiectasis recommend specialised nebulisers for inhaled antibiotics, but are often limited by availability and cost of nebulisation devices https://bit.ly/40FvFdZ.
January 2024: ERJ Open Research
#28
RANDOMIZED CONTROLLED TRIAL
Sarah Derby, Mark R Jackson, Karin Williams, Jamie Stobo, Caroline Kelly, Lorna Sweeting, Shumaila Shad, Christopher Herbert, Susan C Short, Aoife Williamson, Allan James, Stefan Nowicki, Helen Bulbeck, Anthony J Chalmers
PURPOSE: Patients with glioblastoma who are older or have poor performance status (PS) experience particularly poor clinical outcomes. At the time of study initiation, these patients were treated with short-course radiation therapy (40 Gy in 15 fractions). Olaparib is an oral inhibitor of the DNA repair enzyme poly (ADP-ribose) polymerase (PARP) that is well tolerated as a single agent but exacerbates acute radiation toxicity in extracranial sites. Preclinical data predicted that PARP inhibitors would enhance radiosensitivity in glioblastoma without exacerbating adverse effects on the normal brain...
April 1, 2024: International Journal of Radiation Oncology, Biology, Physics
#29
JOURNAL ARTICLE
Renate Kos, Myrofora Goutaki, Helene E Kobbernagel, Bruna Rubbo, Amelia Shoemark, Stefano Aliberti, Josje Altenburg, Pinelopi Anagnostopoulou, Rodrigo A Athanazio, Nicole Beydon, Sharon D Dell, Nagehan Emiralioglu, Thomas W Ferkol, Michael R Loebinger, Natalie Lorent, Bernard Maître, June Marthin, Lucy C Morgan, Kim G Nielsen, Felix C Ringshausen, Michal Shteinberg, Harm A W M Tiddens, Anke H Maitland-Van der Zee, James D Chalmers, Jane S A Lucas, Eric G Haarman
BACKGROUND: Consistent use of reliable and clinically appropriate outcome measures is a priority for clinical trials, with clear definitions to allow comparability. We aimed to develop a core outcome set (COS) for pulmonary disease interventions in primary ciliary dyskinesia (PCD). METHODS: A multidisciplinary international PCD expert panel was set up. A list of outcomes was created based on published literature. Using a modified three-round e-Delphi technique, the panel was asked to decide on relevant end-points related to pulmonary disease interventions and how they should be reported...
January 2024: ERJ Open Research
#30
JOURNAL ARTICLE
Michal Shteinberg, James D Chalmers, Jayanth K Narayana, Alison J Dicker, Michal A Rahat, Elina Simanovitch, Lucy Bidgood, Shai Cohen, Nili Stein, Nizar Abo-Hilu, James Abbott, Sharon Avital, Einat Fireman-Klein, Hollian Richardson, Emad Muhammad, Jenny Jrbashyan, Sonia Schneer, Najwan Nasrallah, Iya Eisenberg, Sanjay H Chotirmall, Yochai Adir
RATIONALE: Bronchiectasis is an airway inflammatory disease frequently associated with chronic rhinosinusitis (CRS). An eosinophilic endotype of bronchiectasis has recently been described, but detailed testing to differentiate eosinophilic bronchiectasis from asthma has not been performed. OBJECTIVE: This prospective observational study aimed to test the hypotheses that bronchiectasis with CRS is enriched for the eosinophilic phenotype in comparison with bronchiectasis alone and that the eosinophilic bronchiectasis phenotype exists as a separate entity from bronchiectasis associated with asthma...
January 9, 2024: Annals of the American Thoracic Society
#31
JOURNAL ARTICLE
Brendon L Neuen, Min Jun, James Wick, Sradha Kotwal, Sunil V Badve, Meg J Jardine, Martin Gallagher, John Chalmers, Kellie Nallaiah, Vlado Perkovic, David Peiris, Anthony Rodgers, Mark Woodward, Paul E Ronksley
BACKGROUND: Sodium glucose co-transporter 2 (SGLT2) inhibitors reduce the risk of kidney failure and death in patients with chronic kidney disease (CKD) but are underused. We evaluated the number of patients with CKD in Australia that would be eligible for treatment and estimated the number of cardiorenal and kidney failure events that could be averted with improved uptake of SGLT2 inhibitors. METHODS: This cross-sectional observational study leveraged nationally representative primary care data from 392 Australian general practices (MedicineInsight) between 1 January 2020 and 31 December 2021...
February 2024: The Lancet Regional Health. Western Pacific
#32
EDITORIAL
Don D Sin, James D Chalmers
No abstract text is available yet for this article.
January 2024: European Respiratory Journal
#33
JOURNAL ARTICLE
James N Moy, Ariff Mohammed Amin, Claire Chalmers-Watson, Rezwona Chowdhury, Camilla Forssten, Jun Fu, Sarit Ghosh, Jeffrey D Harris, Simon Kordowich, Yin Li, Wenchi Lin, Stuart Mackay-Thomas, Marc Mickiewicz, Nikesh Patel, Salvador Resino, Tamsin Sevenoaks, Michael A Tugetman, Jorge Valencia, Roy Vijesurier, Nikki White, Christopher W Woods, Patrick T Kennedy, Pablo Ryan
BACKGROUND: The Panbio™ COVID-19 IgG Rapid Test Device ("Panbio™") detects IgG antibodies against the SARS-CoV-2 spike protein from viral infection or vaccination. OBJECTIVES: To determine the diagnostic sensitivity and specificity of the Panbio™ professional use test, using fingerstick whole blood and venous plasma. STUDY DESIGN: Fingerstick whole blood and venous plasma from each participant were tested with Panbio™ and compared against the SARS-CoV-2 IgG II assay on the Abbott Architect™ platform (Europe) or the equivalent AdviseDx SARS-CoV-2 IgG II Abbott Alinity i™ platform (US)...
December 2023: Heliyon
#34
JOURNAL ARTICLE
Merete B Long, Andrew Jm Howden, Holly R Keir, Christina M Rollings, Yan Hui Giam, Thomas Pembridge, Lilia Delgado, Hani Abo-Leyah, Amy F Lloyd, Gabriel Sollberger, Rebecca Hull, Amy Gilmour, Chloe Hughes, Benjamin Jm New, Diane Cassidy, Amelia Shoemark, Hollian Richardson, Angus I Lamond, Doreen A Cantrell, James D Chalmers, Alejandro J Brenes
BACKGROUND: Neutrophils are important in the pathophysiology of COVID-19 but the molecular changes contributing to altered neutrophil phenotypes following SARS-CoV-2 infection are not fully understood. We used quantitative mass spectrometry-based proteomics to explore neutrophil phenotypes immediately following acute SARS-CoV-2 infection and during recovery. METHODS: Prospective observational study of hospitalised patients with PCR-confirmed SARS-CoV-2 infection (May-December 2020)...
December 14, 2023: European Respiratory Journal
#35
REVIEW
Anne B Chang, Jeanette Boyd, Andrew Bush, Adam T Hill, Zena Powell, Angela Zacharasiewicz, Efthymia Alexopoulou, Andrew J Collaro, James D Chalmers, Carolina Constant, Konstantinos Douros, Rebecca Fortescue, Matthias Griese, Jonathan Grigg, Andreas Hector, Bulent Karadag, Oleksandr Mazulov, Fabio Midulla, Alexander Moeller, Marijke Proesmans, Christine Wilson, Stephanie T Yerkovich, Ahmad Kantar, Keith Grimwood
Improving the treatment of non-cystic fibrosis bronchiectasis in children and adolescents requires high-quality research with outcomes that meet study objectives and are meaningful for patients and their parents and caregivers. In the absence of systematic reviews or agreement on the health outcomes that should be measured in paediatric bronchiectasis, we established an international, multidisciplinary panel of experts to develop a core outcome set (COS) that incorporates patient and parent perspectives. We undertook a systematic review from which a list of 21 outcomes was constructed; these outcomes were used to inform the development of separate surveys for ranking by parents and patients and by health-care professionals...
December 6, 2023: Lancet Respiratory Medicine
#36
JOURNAL ARTICLE
Annika Åstrand, Steven J Kiddle, Rohith Siva Ganesh Mudedla, Sanchita Porwal, Kaushik Chafekar, Shubh Agrawal, Carlos Seminario, James D Chalmers, Ioannis Psallidas
RATIONALE: Bronchiectasis is a chronic, progressive disease of bronchial dilation, inflammation, and scarring leading to impaired mucociliary clearance and increased susceptibility to infection. Identified causes include previous severe respiratory infections. A small, single-center UK study demonstrated a reduction in bronchiectasis exacerbations during the first year of the COVID-19 pandemic. No studies have been conducted in a US (commercially insured) cohort to date. OBJECTIVE: To explore the impact of the COVID-19 pandemic on the frequency of exacerbations in a large cohort of commercially insured US patients with bronchiectasis by testing the hypothesis that US patients with bronchiectasis had fewer exacerbations during the pandemic...
November 14, 2023: Annals of the American Thoracic Society
#37
JOURNAL ARTICLE
Tom Wilkinson, Anthony De Soyza, Miles Carroll, James D Chalmers, Michael G Crooks, Gareth Griffiths, Manu Shankar-Hari, Ling-Pei Ho, Alex Horsley, Chris Kell, Beatriz Lara, Biswa Mishra, Rachel Moate, Clive Page, Hitesh Pandya, Jason Raw, Fred Reid, Dinesh Saralaya, Ian C Scott, Salman Siddiqui, Andy Ustianowski, Natalie van Zuydam, Ashley Woodcock, Dave Singh
BACKGROUND: Increased serum interleukin (IL)-33 predicts poor outcomes in patients hospitalised with coronavirus disease 2019 (COVID-19). We examined the efficacy and safety of tozorakimab, a monoclonal antibody that neutralises IL-33, in improving outcomes in ACCORD-2 (EudraCT: 2020-001736-95). METHODS: ACCORD-2 was an open-label, phase 2a study in adults hospitalised with COVID-19. Patients were randomised 1:1 to tozorakimab 300 mg plus standard of care (SoC) or SoC alone...
September 2023: ERJ Open Research
#38
EDITORIAL
Beatriz Herrero-Cortina, Arietta Spinou, Ana Oliveira, Brenda O'Neill, Cristina Jácome, Simone Dal Corso, William Poncin, Gerard Muñoz, Deniz Inal-Ince, Victoria Alcaraz-Serrano, Gregory Reychler, Angela Bellofiore, Annette Posthumus, James D Chalmers, Annemarie L Lee
No abstract text is available yet for this article.
October 2023: European Respiratory Journal
#39
EDITORIAL
James D Chalmers, Amelia Shoemark
No abstract text is available yet for this article.
October 2023: Chest
#40
JOURNAL ARTICLE
Miguel Barbosa, James D Chalmers
Bronchiectasis is a final common pathway of a wide variety of underlying conditions including infectious, autoimmune, allergic, genetic and inflammatory conditions. Patients experience a chronic disease with variable clinical symptoms and course, but most experience cough, sputum production and recurrent exacerbations. Symptoms of bronchiectasis lead to poor quality of life and exacerbations are the major driver of morbidity and mortality. Patients are often chronically infected with bacteria with the most common being Pseudomonas aeruginosa and Haemophilus influenzae...
September 30, 2023: La Presse Médicale
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