keyword
MENU ▼
Read by QxMD icon Read
search

james chalmers

keyword
https://www.readbyqxmd.com/read/29788953/-the-missing-ingredient-the-patient-perspective-of-health-related-quality-of-life-in-bronchiectasis-a-qualitative-study
#1
Emily K Dudgeon, Megan Crichton, James D Chalmers
BACKGROUND: Bronchiectasis is a heterogeneous disease which affects quality of life. Measuring symptoms and quality of life has proved challenging and research is limited by extrapolation of questionnaires and treatments from other diseases. The objective of this study was to identify the major contributors to quality of life in bronchiectasis and to evaluate existing health related quality of life questionnaires in bronchiectasis. METHODS: Eight adults with bronchiectasis participated in one to one semi-structured interviews...
May 22, 2018: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/29788944/bronchiectasis-an-emerging-global-epidemic
#2
EDITORIAL
Sanjay H Chotirmall, James D Chalmers
Bronchiectasis has an increasing profile within respiratory medicine. This chronic and irreversible airways disease is common but suffers from a lack of evidenced based therapy for patients and, a lack of understanding of its inherent heterogeneity. Research focused on bronchiectasis must therefore be prioritized if we are to adequately address this evolving clinical problem. This special issue on bronchiectasis focuses on its clinical, microbiological and therapeutic aspects. By bringing together a unique collection of original research and review articles, we hope this issue will showcase international research efforts, encourage future research collaborations and stimulate debate...
May 22, 2018: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/29788932/geographic-variation-in-the-aetiology-epidemiology-and-microbiology-of-bronchiectasis
#3
REVIEW
Ravishankar Chandrasekaran, Micheál Mac Aogáin, James D Chalmers, Stuart J Elborn, Sanjay H Chotirmall
Bronchiectasis is a disease associated with chronic progressive and irreversible dilatation of the bronchi and is characterised by chronic infection and associated inflammation. The prevalence of bronchiectasis is age-related and there is some geographical variation in incidence, prevalence and clinical features. Most bronchiectasis is reported to be idiopathic however post-infectious aetiologies dominate across Asia especially secondary to tuberculosis. Most focus to date has been on the study of airway bacteria, both as colonisers and causes of exacerbations...
May 22, 2018: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/29642882/assessing-the-healthcare-resource-use-associated-with-inappropriate-prescribing-of-inhaled-corticosteroids-for-people-with-chronic-obstructive-pulmonary-disease-copd-in-gold-groups-a-or-b-an-observational-study-using-the-clinical-practice-research-datalink
#4
James D Chalmers, Chris Poole, Samantha Webster, Abigail Tebboth, Scott Dickinson, Alicia Gayle
BACKGROUND: Recent recommendations from the Global Initiative for Chronic Obstructive Lung Disease (GOLD) position inhaled corticosteroids (ICS) for use in chronic obstructive pulmonary disease (COPD) patients experiencing exacerbations (≥ 2 or ≥ 1 requiring hospitalisation); i.e. GOLD groups C and D. However, it is known that ICS is frequently prescribed for patients with less severe COPD. Potential drivers of inappropriate ICS use may be historical clinical guidance or a belief among physicians that intervening early with ICS would improve outcomes and reduce resource use...
April 11, 2018: Respiratory Research
https://www.readbyqxmd.com/read/29611441/juvenile-cerebral-ischemia-reveals-age-dependent-bdnf-trkb-signaling-changes-novel-mechanism-of-recovery-and-therapeutic-intervention
#5
Robert M Dietz, James E Orfila, Krista M Rodgers, Olivia P Patsos, Guiying Deng, Nicholas Chalmers, Nidia Quillinan, Richard J Traystman, Paco S Herson
Global ischemia in childhood often leads to poor neurologic outcomes, including learning and memory deficits. Using our novel model of childhood cardiac arrest/cardiopulmonary resuscitation (CA/CPR), we investigate the mechanism of ischemia-induced cognitive deficits and recovery. Memory is impaired seven days after juvenile CA/CPR and completely recovers by 30 days. Consistent with this remarkable recovery not observed in adults, hippocampal long-term potentiation (LTP) is impaired 7-14 days after CA/CPR, recovering by 30 days...
January 1, 2018: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/29605214/burden-of-pneumococcal-community-acquired-pneumonia-in-adults-across-europe-a-literature-review
#6
REVIEW
Antoni Torres, Catia Cillóniz, Francesco Blasi, James D Chalmers, Jacques Gaillat, Nathalie Dartois, Heinz-Josef Schmitt, Tobias Welte
BACKGROUND: The burden of community-acquired pneumonia (CAP) caused by Streptococcus pneumoniae (pneumococcus) among adults in Europe is poorly defined. METHODS: Structured searches of PubMed were conducted to identify the incidence of pneumococcal CAP among adults across Europe. RESULTS: The overall incidence rates for CAP was 68-7000 per 100,000 and the incidence in hospitalised CAP cases of all causes was 16-3581 per 100,000. In general the incidence of CAP increased consistently with age...
April 2018: Respiratory Medicine
https://www.readbyqxmd.com/read/29594237/paradigm-2-two-parallel-phase-i-studies-of-olaparib-and-radiotherapy-or-olaparib-and-radiotherapy-plus-temozolomide-in-patients-with-newly-diagnosed-glioblastoma-with-treatment-stratified-by-mgmt-status
#7
Ben Fulton, Susan C Short, Allan James, Stefan Nowicki, Catherine McBain, Sarah Jefferies, Caroline Kelly, Jon Stobo, Anna Morris, Aoife Williamson, Anthony J Chalmers
Glioblastoma has a dismal prognosis and molecular targeted agents have failed to improve outcomes to date. PARADIGM-2 is a phase I dose escalation study evaluating olaparib plus radiotherapy ± temozolomide in newly diagnosed glioblastoma, using MGMT methylation status to stratify patients and inform treatment schedules.
January 2018: Clinical and Translational Radiation Oncology
https://www.readbyqxmd.com/read/29587336/oral-versus-inhaled-antibiotics-for-bronchiectasis
#8
REVIEW
Sally Spencer, Lambert M Felix, Stephen J Milan, Rebecca Normansell, Pieter C Goeminne, James D Chalmers, Tim Donovan
BACKGROUND: Bronchiectasis is a chronic inflammatory disease characterised by a recurrent cycle of respiratory bacterial infections associated with cough, sputum production and impaired quality of life. Antibiotics are the main therapeutic option for managing bronchiectasis exacerbations. Evidence suggests that inhaled antibiotics may be associated with more effective eradication of infective organisms and a lower risk of developing antibiotic resistance when compared with orally administered antibiotics...
March 27, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29567837/the-brd3-et-domain-recognizes-a-short-peptide-motif-through-a-mechanism-that-is-conserved-across-chromatin-remodelers-and-transcriptional-regulators
#9
Dorothy C Wai, Taylor N Szyszka, Amy E Campbell, Cherry Kwong, Lorna E Wilkinson-White, Ana P G Silva, Jason K K Low, Ann H Kwan, Roland Gamsjaeger, James N Chalmers, Wayne M Patrick, Bin Lu, Christopher R Vakoc, Gerd A Blobel, Joel P Mackay
Members of the bromodomain and extra-terminal domain (BET) family of proteins (bromodomain-containing (BRD) 2, 3, 4 and T) are widely expressed and highly conserved regulators of gene expression in eukaryotes. These proteins have been intimately linked to human disease and more than a dozen clinical trials are currently underway to test BET-protein inhibitors as modulators of cancer therapies. However, although it is clear that these proteins use their bromodomains to bind both histones and transcription factors bearing acetylated lysine residues, the molecular mechanisms by which BET-family proteins regulate gene expression are not well defined...
March 22, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29558164/the-elusive-hunt-for-a-reliable-biomarker-in-community-acquired-pneumonia-are-we-searching-for-something-that-can-t-exist
#10
Grant Waterer, James Chalmers
No abstract text is available yet for this article.
March 20, 2018: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29543980/macrolide-antibiotics-for-bronchiectasis
#11
REVIEW
Carol Kelly, James D Chalmers, Iain Crossingham, Nicola Relph, Lambert M Felix, David J Evans, Stephen J Milan, Sally Spencer
BACKGROUND: Bronchiectasis is a chronic respiratory disease characterised by abnormal and irreversible dilatation and distortion of the smaller airways. Bacterial colonisation of the damaged airways leads to chronic cough and sputum production, often with breathlessness and further structural damage to the airways. Long-term macrolide antibiotic therapy may suppress bacterial infection and reduce inflammation, leading to fewer exacerbations, fewer symptoms, improved lung function, and improved quality of life...
March 15, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29514308/genetic-diversity-of-cryptosporidium-hominis-in-a-bangladeshi-community-as-revealed-by-whole-genome-sequencing
#12
Carol A Gilchrist, James A Cotton, Cecelia Burkey, Tuhinur Arju, Allissia Gilmartin, Ye Lin, Emtiaz Ahmed, Kevin Steiner, Masud Alam, Shahnawaz Ahmed, Guy Robinson, Sultan Uz Zaman, Mamun Kabir, Mandy Sanders, Rachel M Chalmers, Tahmeed Ahmed, Jennie Z Ma, Rashidul Haque, A S G Faruque, Matthew Berriman, William A Petri
We studied the genetic diversity of Cryptosporidium hominis infections in slum dwelling infants from Dhaka over a two-year period. C. hominis infections were common during the monsoon, and were genetically diverse as measured by gp60 genotyping and whole genome resequencing. Recombination in the parasite was evidenced by the decay of linkage disequilibrium in the genome over less than 300 bp. Regions of the genome with high levels of polymorphism were also identified.  Yet to be determined is if genomic diversity is responsible in part for the high rate of reinfection, seasonality and varied clinical presentations of cryptosporidiosis in this population...
March 5, 2018: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29501241/identification-of-pseudomonas-aeruginosa-and-airway-bacterial-colonization-by-an-electronic-nose-in-bronchiectasis
#13
Guillermo Suarez-Cuartin, Jordi Giner, José Luis Merino, Ana Rodrigo-Troyano, Anna Feliu, Lidia Perea, Ferran Sanchez-Reus, Diego Castillo, Vicente Plaza, James D Chalmers, Oriol Sibila
RATIONALE: Airway colonization by Potentially Pathogenic Microorganisms (PPM) in bronchiectasis is associated with worse clinical outcomes. The electronic nose is a non-invasive technology capable of distinguishing volatile organic compounds (VOC) in exhaled breath. We aim to explore if an electronic nose can reliably discriminate airway bacterial colonization in patients with bronchiectasis. METHODS: Seventy-three clinically stable bronchiectasis patients were included...
March 2018: Respiratory Medicine
https://www.readbyqxmd.com/read/29493334/bronchiectasis-exacerbations-are-heart-breaking
#14
James D Chalmers
No abstract text is available yet for this article.
March 2018: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/29478908/bronchiectasis-new-therapies-and-new-perspectives
#15
REVIEW
James D Chalmers, Sanjay H Chotirmall
European Respiratory Society guidelines for the management of adult bronchiectasis highlight the paucity of treatment options available for patients with this disorder. No treatments have been licensed by regulatory agencies worldwide, and most therapies used in clinical practice are based on very little evidence. Development of new treatments is needed urgently. We did a systematic review of scientific literature and clinical trial registries to identify agents in early-to-late clinical development for bronchiectasis in adults...
February 22, 2018: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/29474808/rebuttal-from-dr-chalmers
#16
EDITORIAL
James D Chalmers
No abstract text is available yet for this article.
April 2018: Chest
https://www.readbyqxmd.com/read/29474807/point-should-an-attempt-be-made-to-withdraw-inhaled-corticosteroids-in-all-patients-with-stable-gold-3-30-%C3%A2-fev-1-50-predicted-copd-yes
#17
EDITORIAL
https://www.readbyqxmd.com/read/29386336/the-independent-contribution-of-pseudomonas-aeruginosa-infection-to-long-term-clinical-outcomes-in-bronchiectasis
#18
David Araújo, Michal Shteinberg, Stefano Aliberti, Pieter C Goeminne, Adam T Hill, Thomas C Fardon, Dusanka Obradovic, Glenda Stone, Marion Trautmann, Angela Davis, Katerina Dimakou, Eva Polverino, Anthony De Soyza, Melissa J McDonnell, James D Chalmers
Pseudomonas aeruginosa is responsible for chronic infection in many bronchiectasis patients but it is not known whether it is associated with worse clinical outcomes independent of the underlying severity of disease.This study analysed data from 2596 bronchiectasis patients included from 10 different bronchiectasis clinical centres across Europe and Israel, with a 5-year follow-up period. Prevalence of P. aeruginosa chronic infection and its independent impact on exacerbations, hospitalisations, quality of life and mortality was assessed...
February 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/29371393/respire-breathing-new-life-into-bronchiectasis
#19
EDITORIAL
Sanjay H Chotirmall, James D Chalmers
No abstract text is available yet for this article.
January 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/29357265/characterisation-of-the-frequent-exacerbator-phenotype-in-bronchiectasis
#20
James D Chalmers, Stefano Aliberti, Anna Filonenko, Michal Shteinberg, Pieter C Goeminne, Adam T Hill, Thomas C Fardon, Dusanka Obradovic, Christoph Gerlinger, Giovanni Sotgiu, Elisabeth Operschall, Robert M Rutherford, Katerina Dimakou, Eva Polverino, Anthony De Soyza, Melissa J McDonnell
RATIONALE: Exacerbations are key events in the natural history of bronchiectasis, but clinical predictors and outcomes of frequently exacerbating patients are not well described. OBJECTIVES: To establish if there is a "frequent exacerbator phenotype" in bronchiectasis and the impact of exacerbations on long-term clinical outcomes. METHODS: We studied bronchiectasis patients enrolled from 10 clinical centres in Europe and Israel, with up to 5-years follow-up...
January 22, 2018: American Journal of Respiratory and Critical Care Medicine
keyword
keyword
115780
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"