Simon T Gustavsson, Tim J Enz, James R Tribble, Mattias Nilsson, Anna Lindqvist, Christina Lindén, Anna Hagström, Carola Rutigliani, Emma Lardner, Gustav Stålhammar, Pete A Williams, Gauti Jóhannesson
PURPOSE: To investigate whether nicotinamide (NAM) modulates retinal vasculature in glaucoma. METHODS: This was a prospective controlled clinical trial investigating animal and human histopathology. Participants included normotensive and ocular hypertensive rats, postmortem human ocular tissue, glaucoma patients (n = 90), and healthy controls (n = 30). The study utilized histopathology, computer-assisted retinal vasculature analysis, optical coherence tomography angiography (OCTA), and NAM treatment...
November 1, 2023: Investigative Ophthalmology & Visual Science