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Glaucoma OCT angiography

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https://www.readbyqxmd.com/read/29462016/diurnal-variations-of-peripapillary-and-macular-vessel-density-in-glaucomatous-eyes-using-ocular-coherence-tomography-angiography
#1
Kaweh Mansouri, Harsha L Rao, Kirsten Hoskens, Elisa D'Alessandro, Elsa M Flores-Reyes, André Mermoud, Robert N Weinreb
PURPOSE: To investigate the diurnal variation in peripapillary and macular vessel density (VD) measurements using optical coherence tomography angiography (OCT-A) and its correlation to intraocular pressure (IOP) changes in glaucoma patients. METHODS: Prospective, observational cross-sectional study including 37 patients (74 eyes; age, 63.8±12.9▒y) with open angle glaucoma. OCT-A imaging and IOP measurements were performed at 08:00, 11:00, 14:00, and 16:00 on a single day...
February 16, 2018: Journal of Glaucoma
https://www.readbyqxmd.com/read/29462015/macular-vessel-density-in-glaucomatous-eyes-with-focal-lamina-cribrosa-defects
#2
Elham Ghahari, Christopher Bowd, Linda M Zangwill, Min Hee Suh, Takuhei Shoji, Kyle A Hasenstab, Luke J Saunders, Sasan Moghimi, Huiyuan Hou, Patricia Isabel C Manalastas, Rafaella C Penteado, Robert N Weinreb
PURPOSE: To compare optical coherence tomography angiography (OCTA) measured macular vessel density and spectral domain optical coherence tomography (SDOCT) measured macular ganglion cell complex (GCC) thickness in primary open-angle glaucoma (POAG) eyes with and without focal lamina cribrosa (LC) defects. METHODS: In this cross-sectional, case-control study of patients with POAG, 46 eyes of 46 patients with LC defects and 54 eyes of 54 patients without observable LC defects were included...
February 16, 2018: Journal of Glaucoma
https://www.readbyqxmd.com/read/29409880/the-effects-of-graded-intraocular-pressure-challenge-on-the-optic-nerve-head
#3
Nimesh Patel, Faith McAllister, Laura Pardon, Ronald Harwerth
Intraocular pressure (IOP) is an important risk factor for glaucoma, and the response of the ONH and surrounding tissues to elevated IOP are often investigated to better understand pathophysiology. In vivo structure including that of the optic nerve head (ONH) and surrounding tissue of the eye are often assessed using optical coherence tomography (OCT). With advances in OCT technology, both large vessels and capillaries can be imaged non-invasively (OCT Angiography). Because a significant portion of retinal thickness is comprised of vasculature, the purpose of the current study was to investigate OCT structural and vascular changes in healthy non-human primate eyes with systematic graded increases and decreases in IOP...
February 1, 2018: Experimental Eye Research
https://www.readbyqxmd.com/read/29394201/structural-and-functional-associations-of-macular-microcirculation-in-the-ganglion-cell-inner-plexiform-layer-in-glaucoma-using-optical-coherence-tomography-angiography
#4
Grace M Richter, Ingy Madi, Zhongdi Chu, Bruce Burkemper, Ryuna Chang, Arman Zaman, Beau Sylvester, Alena Reznik, Amir Kashani, Ruikang K Wang, Rohit Varma
PURPOSE: To quantify retinal microvasculature within the macular ganglion cell-inner plexiform layer (GCIPL) in primary open angle glaucoma (POAG) and normal eyes, determine association of vessel parameters with structural and functional measures, and report diagnostic accuracy of vessel parameters. METHODS: POAG and normal patients underwent 6▒mm×6▒mm macula scans (Angioplex optical coherence tomography angiography [OCTA]; Cirrus HD-OCT 5000); and Humphrey Field Analyzer II-i 24-2 visual field (VF) (Zeiss, Dublin, CA)...
February 1, 2018: Journal of Glaucoma
https://www.readbyqxmd.com/read/29392641/optical-coherence-tomography-angiography-findings-of-an-optic-disc-melanocytoma-in-a-glaucoma-eye
#5
Yoshiyuki Kita, Gábor Hollό, Akiko Murai, Ritsuko Kita, Akito Hirakata
PURPOSE: To determine the optical coherence tomography angiography (OCTA) characteristics of a case of optic disc melanocytoma (ODM) associated with glaucomatous visual field and retinal nerve fiber layer (RNFL) defects in normal tension glaucoma. METHODS: The left eye of a 37-year-old female patient followed for a stable ODM for 10 years was investigated with OCT, OCTA, fluorescein (FA), and indocyanine green (ICGA) angiography. The ODM was unchanged, but a previously unknown inferotemporal neuroretinal rim loss and inferotemporal and superotemporal wedge shape glaucomatous RNFL thinning were seen with corresponding glaucomatous visual field defects...
February 1, 2018: International Ophthalmology
https://www.readbyqxmd.com/read/29390233/oct-angiography-of-the-central-macular-capillary-network-in-glaucoma-patients-and-healthy-controls
#6
Olena Müller, Margarita G Todorova, Torsten Schlote
PURPOSE: We aimed to investigate central macular microvasculature by optical coherence tomography angiography (OCTA) and to analyse its relation to alterations in classical parameters of optical coherence tomography (OCT) in glaucoma patients. METHODS: Using OCTA (Avanti incl. AngioVue; Optovue, Inc., Fremont, CA), the superficial flow (SF) and the superficial non-flow (SNF) area of the macula, as well as the S-ETDRS (based on Early Treatment Diabetic Retinopathy charts)...
February 1, 2018: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/29332249/correlation-of-flow-density-as-measured-using-optical-coherence-tomography-angiography-with-structural-and-functional-parameters-in-glaucoma-patients
#7
Maged Alnawaiseh, Larissa Lahme, Viktoria Müller, André Rosentreter, Nicole Eter
PURPOSE: To evaluate the correlation between flow density, as measured by optical coherence tomography angiography (OCTA), and structural and functional parameters in patients with open-angle glaucoma. METHODS: Thirty-four eyes of 34 patients with open-angle glaucoma and 35 eyes of 35 healthy subjects were prospectively included in this study. OCTA was performed using RTVue XR Avanti with AngioVue. The macula was imaged with a 3 × 3 mm scan and the optic nerve head (ONH) with a 4...
January 13, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/29303879/comparison-of-peripapillary-oct-angiography-vessel-density-and-retinal-nerve-fiber-layer-thickness-measurements-for-their-ability-to-detect-progression-in-glaucoma
#8
Gábor Holló
PURPOSE: To investigate the applicability of peripapillary optical coherence tomography angiography angioflow vessel-density measurements in the retinal nerve fiber layer for the detection of glaucomatous progression; and to compare its performance with that of retinal nerve fiber layer thickness (RNFLT) measurements. METHODS: Prospective RNFLT and vessel-density measurements with the same Angiovue/RTVue-XR instrument were made immediately after each other on one eye of 9 normal, 20 under treatment ocular hypertensive (OHT) and 24 under treatment open-angle glaucoma patients at 6-month intervals for 2 years (5 visits for all eyes)...
January 4, 2018: Journal of Glaucoma
https://www.readbyqxmd.com/read/29303870/the-association-between-macula-and-onh-optical-coherence-tomography-angiography-oct-a-vessel-densities-in-glaucoma-glaucoma-suspect-and-healthy-eyes
#9
Patricia Isabel C Manalastas, Linda M Zangwill, Fabio B Daga, Mark A Christopher, Luke J Saunders, Takuhei Shoji, Tadamichi Akagi, Rafaella C Penteado, Adeleh Yarmohammadi, Min Hee Suh, Felipe A Medeiros, Robert N Weinreb
PURPOSE: To evaluate strength of associations between Optical Coherence Tomography-Angiography (OCT-A) vessel density (VD) measurements in the macula and peripapillary region of the optic nerve head (ONH) with standard structural OCT thickness measures. METHODS: This cross-sectional study included 333 eyes of 219 primary open angle glaucoma patients, 41 glaucoma suspects, and 73 healthy participants from the Diagnostics Innovations in Glaucoma Study (DIGS) with good quality OCT-A images...
January 4, 2018: Journal of Glaucoma
https://www.readbyqxmd.com/read/29260124/utility-of-optical-coherence-tomography-angiography-in-detecting-glaucomatous-damage-in-a-uveitic-patient-with-disc-congestion-a-case-report
#10
Jiun Lap Do, Beau Sylvester, Anoush Shahidzadeh, Ruikang K Wang, Zhongdi Chu, Vivek Patel, Grace Marie Richter
Purpose: To report a case of uveitic glaucoma with a congested optic disc where optical coherence tomography angiography (OCT-A) provided diagnostic utility in assessing glaucomatous damage but optical coherence tomography (OCT) alone had limited utility. Observations: We report a case of a 33-year-old Caucasian female referred to the USC Roski Eye Institute for uncontrolled intraocular pressure (IOP) in the left eye. She was managed by an outside provider for 6 months, where her IOP ranged from 28 to 42 mm Hg in the left eye on maximally tolerated medical therapy...
December 2017: American Journal of Ophthalmology Case Reports
https://www.readbyqxmd.com/read/29224927/central-visual-field-damage-and-parapapillary-choroidal-microvasculature-dropout-in-primary-open-angle-glaucoma
#11
Eun Ji Lee, Tae-Woo Kim, Ji-Ah Kim, Jeong-Ah Kim
PURPOSE: To determine whether microvasculature dropout (MvD) in the parapapillary choroid is related to the presence of central visual field defects in primary open-angle glaucoma (POAG). DESIGN: Cross-sectional observational study. PARTICIPANTS: Thirty-two POAG patients with an initial parafoveal scotoma (IPFS) within a 10° radius in 1 hemifield and 42 POAG patients with an initial nasal step (INS) within the nasal periphery outside 10° of fixation in 1 hemifield...
December 7, 2017: Ophthalmology
https://www.readbyqxmd.com/read/29199863/optical-coherence-tomography-based-scattering-properties-of-retinal-vessels-in-glaucoma-patients
#12
Robert Kromer, Sebastian Boelefahr, Brendan Eck, Shafin Rahman, Maren Klemm
PURPOSE: Clinical trials have demonstrated that retinal blood flow deficiencies are present in patients with open-angle glaucoma (OAG). We introduce a method for facilitating retinal vessel analysis: The intensity of the distal shadow of vessels in optical coherence tomography (OCT) caused by the scattered signal is analyzed, compared between healthy subjects and OAG patients and correlated with OCT angiography (OCT-A) flow density. PATIENTS AND METHODS: We recruited 80 patients with diagnosed OAG (mean age 63...
December 4, 2017: Current Eye Research
https://www.readbyqxmd.com/read/29183045/peripapillary-microvascular-improvement-and-lamina-cribrosa-depth-reduction-after-trabeculectomy-in-primary-open-angle-glaucoma
#13
Joong Won Shin, Kyung Rim Sung, Ki Bang Uhm, Jaehyuck Jo, Yeji Moon, Min Kyung Song, Ji Yoon Song
Purpose: To evaluate peripapillary microvascular changes in patients with primary open-angle glaucoma (POAG) after trabeculectomy using optical coherence tomography (OCT) angiography, and to determine the influence of lamina cribrosa (LC) displacement on changes in peripapillary microvasculature. Methods: The peripapillary retinal microvasculature and LC were imaged using OCT angiography and OCT-enhanced depth imaging, respectively. The microvasculature and LC depth (LCD) were measured before, and 1 week, 1 month, and 3 months after trabeculectomy...
November 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29174012/peripapillary-and-macular-vessel-density-in-patients-with-primary-open-angle-glaucoma-and-unilateral-visual-field-loss
#14
Adeleh Yarmohammadi, Linda M Zangwill, Patricia Isabel C Manalastas, Nathanael J Fuller, Alberto Diniz-Filho, Luke J Saunders, Min Hee Suh, Kyle Hasenstab, Robert N Weinreb
PURPOSE: To characterize OCT angiography (OCT-A) vessel density of patients with primary open-angle glaucoma (POAG) with unilateral visual field (VF) loss. DESIGN: Cross-sectional study. PARTICIPANTS: A total of 33 patients with POAG with a VF defect in 1 eye (mean VF mean deviation [MD], -3.9±3.1 decibels [dB]) and normal VF in the other eye (mean VF MD, -0.2±0.9 dB) and 33 healthy eyes. METHODS: All subjects underwent OCT-A imaging, spectral-domain (SD)-OCT imaging, and VF testing...
November 22, 2017: Ophthalmology
https://www.readbyqxmd.com/read/29171726/factors-associated-with-deep-circulation-in-the-peripapillary-chorioretinal-atrophy-zone-in-normal-tension-glaucoma-with-myopic-disc
#15
Naoki Kiyota, Hiroshi Kunikata, Seri Takahashi, Yukihiro Shiga, Kazuko Omodaka, Toru Nakazawa
PURPOSE: To investigate factors associated with choroidal microcirculation in the peripapillary chorioretinal atrophy (PPA) zone in eyes with normal-tension glaucoma (NTG) and myopic disc. METHODS: In 100 eyes of 100 NTG patients with myopic disc and 20 eyes of 20 age-matched myopic controls, 4.5 × 4.5 mm scans were made of the optic nerve head with optical coherence tomography angiography (OCTA). Peripapillary chorioretinal atrophy (PPA) area and PPA superficial choroidal image intensity (PPA-CI) were calculated with image j software...
November 24, 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/29140817/new-developments-in-optical-coherence-tomography-imaging-for-glaucoma
#16
Jean-Claude Mwanza, Donald L Budenz
PURPOSE OF REVIEW: Since its introduction in ophthalmology, optical coherence tomography (OCT) has undergone significant advances in imaging protocols, algorithms, and addition of new parameters which have maximized its potential for diagnosing, evaluating the response to treatment, and assessing the progression of various ocular diseases, including glaucoma. This review provides an update on recent developments in OCT with respect to the management of glaucoma. RECENT FINDINGS: Most recent notable developments include the introduction of the minimum distance band, which is a three-dimensional optic nerve head parameter, and Swept-Source OCT with its single wide-field scanning capability...
November 14, 2017: Current Opinion in Ophthalmology
https://www.readbyqxmd.com/read/29114838/optical-coherence-tomography-angiography-macular-and-peripapillary-vessel-perfusion-density-in-healthy-subjects-glaucoma-suspects-and-glaucoma-patients
#17
COMPARATIVE STUDY
Giacinto Triolo, Alessandro Rabiolo, Nathan D Shemonski, Ali Fard, Federico Di Matteo, Riccardo Sacconi, Paolo Bettin, Stephanie Magazzeni, Giuseppe Querques, Luis E Vazquez, Piero Barboni, Francesco Bandello
Purpose: To evaluate macular and peripapillary vessel perfusion density (VD) in glaucoma suspects (GS) and glaucoma patients; to correlate ganglion cell-inner plexiform layer (GCIPL) and retinal nerve fiber layer (RNFL) thicknesses with macular and peripapillary VD; and to evaluate the diagnostic accuracy of the structural and vascular parameters. Methods: A consecutive series of GS, glaucoma patients, and healthy subjects was prospectively recruited from July 1, 2016, to January 31, 2017...
November 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29101405/parapapillary-deep-layer-microvasculature-dropout-in-primary-open-angle-glaucoma-eyes-with-a-parapapillary-%C3%AE-zone
#18
Eun Ji Lee, Tae-Woo Kim, Ji-Ah Kim, Jeong-Ah Kim
Purpose: To explore the clinical characteristics of parapapillary deep-layer microvasculature dropout (MvD) associated with parapapillary γ-zone in primary open-angle glaucoma (POAG). Methods: A total of 150 eyes with POAG and 75 age- and axial length-matched control eyes, both having parapapillary γ-zone as determined by spectral-domain (SD) optical coherence tomography (OCT), were included. Parapapillary MvD was defined as a focal sectoral capillary dropout without any visible microvascular network identified in deep-layer en-face images obtained using swept-source OCT angiography (OCTA)...
November 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29101122/topographic-correlation-between-juxtapapillary-choroidal-thickness-and-parapapillary-deep-layer-microvasculature-dropout-in-primary-open-angle-glaucoma
#19
Seung Hyen Lee, Eun Ji Lee, Tae-Woo Kim
PURPOSE: To investigate the topographic relationship between parapapillary deep-layer microvasculature dropout (MvD) as assessed by optical coherence tomography (OCT) angiography (OCTA) and the juxtapapillary choroidal thickness (JPCT) in primary open-angle glaucoma (POAG). METHODS: A total of 194 eyes (138 POAG and 56 control eyes) having parapapillary atrophy (PPA) were imaged using the swept-source OCT and OCTA to examine the microstructure of PPA and measure the JPCT, and to determine the presence of the MvD...
November 3, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/29049726/comparison-of-sectoral-structure-function-relationships-in-glaucoma-vessel-density-versus-thickness-in-the-peripapillary-retinal-nerve-fiber-layer
#20
COMPARATIVE STUDY
Kimikazu Sakaguchi, Tomomi Higashide, Sachiko Udagawa, Shinji Ohkubo, Kazuhisa Sugiyama
Purpose: To compare the sectoral structure-function relationships in glaucoma between two structural parameters, vessel density (VD) and thickness, in the peripapillary retinal nerve fiber layer (RNFL). Methods: Optical coherence tomography (OCT) angiography (AngioVue/RTVue-XR) for VD and OCT (RS-3000) for peripapillary RNFL thickness were performed in 129 eyes from 129 subjects (94 glaucoma, 17 glaucoma suspects, and 18 normal eyes). Humphrey visual field (VF) tests were performed using a SITA standard 24-2 program...
October 1, 2017: Investigative Ophthalmology & Visual Science
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