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Glaucoma OCT angiography

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https://www.readbyqxmd.com/read/29664832/optical-coherence-tomography-angiography-macular-vascular-density-measurements-and-the-central-10-2-visual-field-in-glaucoma
#1
Rafaella C Penteado, Linda M Zangwill, Fábio B Daga, Luke J Saunders, Patricia Isabel C Manalastas, Takuhei Shoji, Tadamichi Akagi, Mark Christopher, Adeleh Yarmohammadi, Sasan Moghimi, Robert N Weinreb
PURPOSE: To evaluate the association between macula vascular density assessed by optical coherence tomography angiography (OCT-A) and central visual field (VF) threshold sensitivities in healthy, glaucoma suspect and glaucoma patients. METHODS: A total of 185 eyes from 38 healthy participants, 31 glaucoma suspects, 72 mild glaucoma patients, and 44 moderate/severe glaucoma patients from the Diagnostic Innovations in Glaucoma Study who underwent OCT-A images of the macula and 10-2 VF testing were enrolled in this observational cross-sectional study...
April 16, 2018: Journal of Glaucoma
https://www.readbyqxmd.com/read/29651340/changes-in-flow-density-measured-using-optical-coherence-tomography-angiography-after-istent-insertion-in-combination-with-phacoemulsification-in-patients-with-open-angle-glaucoma
#2
Maged Alnawaiseh, Viktoria Müller, Larissa Lahme, Ralph Laurent Merté, Nicole Eter
Purpose: To evaluate changes in flow density after the implantation of a trabecular microbypass stent (iStent) in combination with cataract surgery. Methods: A total of 48 eyes of 48 patients, who underwent either cataract surgery alone (cataract group) or cataract surgery with implantation of two iStent inject devices (iStent group), were prospectively included in this study. Intraocular pressure (IOP) and flow density data before and after surgery were extracted and analyzed...
2018: Journal of Ophthalmology
https://www.readbyqxmd.com/read/29651339/comparison-of-optical-coherence-tomography-angiography-and-laser-speckle-flowgraphy-for-the-diagnosis-of-normal-tension-glaucoma
#3
Asuka Takeyama, Kyoko Ishida, Ayako Anraku, Masahiro Ishida, Goji Tomita
Purpose: To compare optical coherence tomography angiography (OCT-A) and laser speckle flowgraphy (LSFG) for the diagnosis of normal-tension glaucoma (NTG). Methods: Twenty-eight eyes of 28 patients with NTG and 25 eyes of 25 normal subjects matched for age, refractive errors, systemic blood pressure, and central corneal thickness were evaluated. OCT-A was used to measure whole image vessel density, inside disc vessel density, and peripapillary vessel density; using LSFG, mean blur rate (MBR) inside the whole optic nerve head (ONH) area (MBRA ), and MBR of the vessel area (MBRV ) and tissue area (MBRT ) inside the ONH, were determined...
2018: Journal of Ophthalmology
https://www.readbyqxmd.com/read/29613982/association-between-the-deep-layer-microvasculature-dropout-and-the-visual-field-damage-in-glaucoma
#4
Min Hee Suh, Jun Woo Park, Hae Rang Kim
PURPOSE: To compare the visual field (VF) sensitivity according to the presence of parapapillary deep-layer microvasculature dropout (MvD_P) and focal lamina cribrosa (LC) defect. METHODS: Among 158 open-angle glaucoma patients, 4 groups were formed according to the presence of MvD_P and focal LC defect determined by optical coherence tomography (OCT) angiography and by enhanced depth imaging spectral-domain OCT, respectively: (1) eyes without either focal LC defect or MvD_P (group 1); (2) eyes with focal LC defect but no MvD_P (group 2); (3) eyes without focal LC defect but with MvD_P (group 3); (4) eyes with both focal LC defect and MvD_P (group 4)...
April 2, 2018: Journal of Glaucoma
https://www.readbyqxmd.com/read/29580976/inter-eye-asymmetry-of-optical-coherence-tomography-angiography-vessel-density-in-bilateral-glaucoma-glaucoma-suspect-and-healthy-eyes
#5
Huiyuan Hou, Sasan Moghimi, Linda M Zangwill, Takuhei Shoji, Elham Ghahari, Patricia Isabel C Manalastas, Rafaella C Penteado, Robert N Weinreb
PURPOSE: To investigate inter-eye retinal vessel density asymmetry in healthy, glaucoma suspect, and mild to moderate glaucoma subjects, and its potential utility for early detection of glaucomatous damage. DESIGN: Cross-sectional study. METHODS: 153 subjects including 55 healthy, 32 glaucoma suspect, and 66 glaucoma subjects enrolled in the Diagnostic Innovations in Glaucoma Study(DIGS). Vessel density was obtained from optical coherence tomography angiography (OCT-A) macular and optic nerve head scans...
March 23, 2018: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/29520478/increase-in-the-oct-angiographic-peripapillary-vessel-density-by-rock-inhibitor-ripasudil-instillation-a-comparison-with-brimonidine
#6
Etsuo Chihara, Galina Dimitrova, Tomoyuki Chihara
PURPOSE: To assess the responses of the superficial peripapillary retinal vessel density (VD) and prelaminar flow index (PLFI) to topical Rho-assisted coiled-coil forming protein kinase (ROCK) inhibitor ripasudil and alpha-2 agonist brimonidine using optical coherence tomography angiography. METHODS: This is a prospective, non-randomized, comparative cohort study. We studied the response of optical coherence tomography angiography (OCTA) parameters to drugs in 24 eyes treated with ripasudil and 23 eyes treated with brimonidine at the Sensho-kai Eye Institute...
March 8, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/29486903/choroidal-microvasculature-dropout-is-associated-with-progressive-retinal-nerve-fiber-layer-thinning-in-glaucoma-with-disc-hemorrhage
#7
Hae-Young Lopilly Park, Jin Woo Kim, Chan Kee Park
OBJECTIVE: We used OCT angiography (OCT-A) to investigate parapapillary choroidal microvasculature dropout (MvD) in glaucomatous eyes with or without disc hemorrhage (DH), and the association with changes in retinal nerve fiber layer (RNFL) thickness. DESIGN: An observational case-control study. PARTICIPANTS: Eighty-two open-angle glaucoma (OAG) eyes with DH and 68 OAG eyes without DH that underwent at least 4 serial OCT examinations were included...
February 24, 2018: Ophthalmology
https://www.readbyqxmd.com/read/29462016/diurnal-variations-of-peripapillary-and-macular-vessel-density-in-glaucomatous-eyes-using-ocular-coherence-tomography-angiography
#8
Kaweh Mansouri, Harsha L Rao, Kirsten Hoskens, Elisa D'Alessandro, Elsa M Flores-Reyes, André Mermoud, Robert N Weinreb
PURPOSE: To investigate the diurnal variation in peripapillary and macular vessel density (VD) measurements using optical coherence tomography angiography (OCT-A) and its correlation to intraocular pressure (IOP) changes in glaucoma patients. METHODS: Prospective, observational cross-sectional study including 37 patients (74 eyes; age, 63.8±12.9▒y) with open angle glaucoma. OCT-A imaging and IOP measurements were performed at 08:00, 11:00, 14:00, and 16:00 on a single day...
February 16, 2018: Journal of Glaucoma
https://www.readbyqxmd.com/read/29462015/macular-vessel-density-in-glaucomatous-eyes-with-focal-lamina-cribrosa-defects
#9
Elham Ghahari, Christopher Bowd, Linda M Zangwill, Min Hee Suh, Takuhei Shoji, Kyle A Hasenstab, Luke J Saunders, Sasan Moghimi, Huiyuan Hou, Patricia I C Manalastas, Rafaella C Penteado, Robert N Weinreb
PURPOSE: To compare optical coherence tomography angiography (OCTA) measured macular vessel density and spectral domain optical coherence tomography (SDOCT) measured macular ganglion cell complex (GCC) thickness in primary open-angle glaucoma eyes with and without focal lamina cribrosa (LC) defects. METHODS: In this cross-sectional, case-control study of patients with primary open-angle glaucoma, 46 eyes of 46 patients with LC defects and 54 eyes of 54 patients without observable LC defects were included...
April 2018: Journal of Glaucoma
https://www.readbyqxmd.com/read/29409880/the-effects-of-graded-intraocular-pressure-challenge-on-the-optic-nerve-head
#10
Nimesh Patel, Faith McAllister, Laura Pardon, Ronald Harwerth
Intraocular pressure (IOP) is an important risk factor for glaucoma, and the response of the ONH and surrounding tissues to elevated IOP are often investigated to better understand pathophysiology. In vivo structure including that of the optic nerve head (ONH) and surrounding tissue of the eye are often assessed using optical coherence tomography (OCT). With advances in OCT technology, both large vessels and capillaries can be imaged non-invasively (OCT Angiography). Because a significant portion of retinal thickness is comprised of vasculature, the purpose of the current study was to investigate OCT structural and vascular changes in healthy non-human primate eyes with systematic graded increases and decreases in IOP...
April 2018: Experimental Eye Research
https://www.readbyqxmd.com/read/29394201/structural-and-functional-associations-of-macular-microcirculation-in-the-ganglion-cell-inner-plexiform-layer-in-glaucoma-using-optical-coherence-tomography-angiography
#11
Grace M Richter, Ingy Madi, Zhongdi Chu, Bruce Burkemper, Ryuna Chang, Arman Zaman, Beau Sylvester, Alena Reznik, Amir Kashani, Ruikang K Wang, Rohit Varma
PURPOSE: To quantify retinal microvasculature within the macular ganglion cell-inner plexiform layer (GCIPL) in primary open angle glaucoma (POAG) and normal eyes, determine association of vessel parameters with structural and functional measures, and report diagnostic accuracy of vessel parameters. METHODS: POAG and normal patients underwent 6▒mm×6▒mm macula scans (Angioplex optical coherence tomography angiography [OCTA]; Cirrus HD-OCT 5000); and Humphrey Field Analyzer II-i 24-2 visual field (VF) (Zeiss, Dublin, CA)...
February 1, 2018: Journal of Glaucoma
https://www.readbyqxmd.com/read/29392641/optical-coherence-tomography-angiography-findings-of-an-optic-disc-melanocytoma-in-a-glaucoma-eye
#12
Yoshiyuki Kita, Gábor Hollό, Akiko Murai, Ritsuko Kita, Akito Hirakata
PURPOSE: To determine the optical coherence tomography angiography (OCTA) characteristics of a case of optic disc melanocytoma (ODM) associated with glaucomatous visual field and retinal nerve fiber layer (RNFL) defects in normal tension glaucoma. METHODS: The left eye of a 37-year-old female patient followed for a stable ODM for 10 years was investigated with OCT, OCTA, fluorescein (FA), and indocyanine green (ICGA) angiography. The ODM was unchanged, but a previously unknown inferotemporal neuroretinal rim loss and inferotemporal and superotemporal wedge shape glaucomatous RNFL thinning were seen with corresponding glaucomatous visual field defects...
February 1, 2018: International Ophthalmology
https://www.readbyqxmd.com/read/29390233/oct-angiography-of-the-central-macular-capillary-network-in-glaucoma-patients-and-healthy-controls
#13
Olena Müller, Margarita G Todorova, Torsten Schlote
PURPOSE: We aimed to investigate central macular microvasculature by optical coherence tomography angiography (OCTA) and to analyse its relation to alterations in classical parameters of optical coherence tomography (OCT) in glaucoma patients. METHODS: Using OCTA (Avanti incl. AngioVue; Optovue, Inc., Fremont, CA), the superficial flow (SF) and the superficial non-flow (SNF) area of the macula, as well as the S-ETDRS (based on Early Treatment Diabetic Retinopathy charts)...
February 1, 2018: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/29332249/correlation-of-flow-density-as-measured-using-optical-coherence-tomography-angiography-with-structural-and-functional-parameters-in-glaucoma-patients
#14
Maged Alnawaiseh, Larissa Lahme, Viktoria Müller, André Rosentreter, Nicole Eter
PURPOSE: To evaluate the correlation between flow density, as measured by optical coherence tomography angiography (OCTA), and structural and functional parameters in patients with open-angle glaucoma. METHODS: Thirty-four eyes of 34 patients with open-angle glaucoma and 35 eyes of 35 healthy subjects were prospectively included in this study. OCTA was performed using RTVue XR Avanti with AngioVue. The macula was imaged with a 3 × 3 mm scan and the optic nerve head (ONH) with a 4...
March 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/29303879/comparison-of-peripapillary-oct-angiography-vessel-density-and-retinal-nerve-fiber-layer-thickness-measurements-for-their-ability-to-detect-progression-in-glaucoma
#15
Gábor Holló
PURPOSE: The aim of this study was to investigate the applicability of peripapillary optical coherence tomography angiography angioflow vessel density measurements in the retinal nerve fiber layer for the detection of glaucomatous progression and to compare its performance with that of retinal nerve fiber layer thickness (RNFLT) measurements. METHODS: Prospective RNFLT and vessel density measurements with the same Angiovue/RTVue-XR instrument were made immediately one after another on 1 eye of 9 normal eyes, 20 under treatment ocular hypertension eyes, and 24 under treatment open angle glaucoma eyes at 6-month intervals for 2 years (5 visits for all eyes)...
March 2018: Journal of Glaucoma
https://www.readbyqxmd.com/read/29303870/the-association-between-macula-and-onh-optical-coherence-tomography-angiography-oct-a-vessel-densities-in-glaucoma-glaucoma-suspect-and-healthy-eyes
#16
Patricia I C Manalastas, Linda M Zangwill, Fabio B Daga, Mark A Christopher, Luke J Saunders, Takuhei Shoji, Tadamichi Akagi, Rafaella C Penteado, Adeleh Yarmohammadi, Min H Suh, Felipe A Medeiros, Robert N Weinreb
PURPOSE: To evaluate strength of associations between optical coherence tomography (OCT)-angiography vessel density (VD) measurements in the macula and peripapillary region of the optic nerve head (ONH) with standard structural OCT thickness measures. MATERIALS AND METHODS: This cross-sectional study included 333 eyes of 219 primary open-angle glaucoma patients, 41 glaucoma suspects, and 73 healthy participants from the Diagnostic Innovations in Glaucoma Study (DIGS) with good quality OCT angiography images...
March 2018: Journal of Glaucoma
https://www.readbyqxmd.com/read/29260124/utility-of-optical-coherence-tomography-angiography-in-detecting-glaucomatous-damage-in-a-uveitic-patient-with-disc-congestion-a-case-report
#17
Jiun Lap Do, Beau Sylvester, Anoush Shahidzadeh, Ruikang K Wang, Zhongdi Chu, Vivek Patel, Grace Marie Richter
Purpose: To report a case of uveitic glaucoma with a congested optic disc where optical coherence tomography angiography (OCT-A) provided diagnostic utility in assessing glaucomatous damage but optical coherence tomography (OCT) alone had limited utility. Observations: We report a case of a 33-year-old Caucasian female referred to the USC Roski Eye Institute for uncontrolled intraocular pressure (IOP) in the left eye. She was managed by an outside provider for 6 months, where her IOP ranged from 28 to 42 mm Hg in the left eye on maximally tolerated medical therapy...
December 2017: American Journal of Ophthalmology Case Reports
https://www.readbyqxmd.com/read/29224927/central-visual-field-damage-and-parapapillary-choroidal-microvasculature-dropout-in-primary-open-angle-glaucoma
#18
Eun Ji Lee, Tae-Woo Kim, Ji-Ah Kim, Jeong-Ah Kim
PURPOSE: To determine whether microvasculature dropout (MvD) in the parapapillary choroid is related to the presence of central visual field defects in primary open-angle glaucoma (POAG). DESIGN: Cross-sectional observational study. PARTICIPANTS: Thirty-two POAG patients with an initial parafoveal scotoma (IPFS) within a 10° radius in 1 hemifield and 42 POAG patients with an initial nasal step (INS) within the nasal periphery outside 10° of fixation in 1 hemifield...
December 7, 2017: Ophthalmology
https://www.readbyqxmd.com/read/29199863/optical-coherence-tomography-based-scattering-properties-of-retinal-vessels-in-glaucoma-patients
#19
Robert Kromer, Sebastian Boelefahr, Brendan Eck, Shafin Rahman, Maren Klemm
PURPOSE: Clinical trials have demonstrated that retinal blood flow deficiencies are present in patients with open-angle glaucoma (OAG). We introduce a method for facilitating retinal vessel analysis: The intensity of the distal shadow of vessels in optical coherence tomography (OCT) caused by the scattered signal is analyzed, compared between healthy subjects and OAG patients and correlated with OCT angiography (OCT-A) flow density. PATIENTS AND METHODS: We recruited 80 patients with diagnosed OAG (mean age 63...
December 4, 2017: Current Eye Research
https://www.readbyqxmd.com/read/29183045/peripapillary-microvascular-improvement-and-lamina-cribrosa-depth-reduction-after-trabeculectomy-in-primary-open-angle-glaucoma
#20
Joong Won Shin, Kyung Rim Sung, Ki Bang Uhm, Jaehyuck Jo, Yeji Moon, Min Kyung Song, Ji Yoon Song
Purpose: To evaluate peripapillary microvascular changes in patients with primary open-angle glaucoma (POAG) after trabeculectomy using optical coherence tomography (OCT) angiography, and to determine the influence of lamina cribrosa (LC) displacement on changes in peripapillary microvasculature. Methods: The peripapillary retinal microvasculature and LC were imaged using OCT angiography and OCT-enhanced depth imaging, respectively. The microvasculature and LC depth (LCD) were measured before, and 1 week, 1 month, and 3 months after trabeculectomy...
November 1, 2017: Investigative Ophthalmology & Visual Science
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