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Glaucoma OCT angiography

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https://www.readbyqxmd.com/read/29907322/macular-and-optic-nerve-head-vessel-density-and-progressive-retinal-nerve-fiber-layer-loss-in-glaucoma
#1
Sasan Moghimi, Linda M Zangwill, Rafaella C Penteado, Kyle Hasenstab, Elham Ghahari, Huiyuan Hou, Mark Christopher, Adeleh Yarmohammadi, Patricia Isabel C Manalastas, Takuhei Shoji, Christopher Bowd, Robert N Weinreb
PURPOSE: To investigate prospectively the relationship between macular and peripapillary vessel density and progressive retinal nerve fiber layer (RNFL) loss in patients with mild to moderate primary open-angle glaucoma. DESIGN: Prospective, observational study. PARTICIPANTS: One hundred thirty-two eyes of 83 patients with glaucoma followed up for at least 2 years (average: 27.3±3.36 months). METHODS: Measurements of macular whole image vessel density (m-wiVD) and optic nerve head whole image vessel density (onh-wiVD) were acquired at baseline using OCT angiography...
June 12, 2018: Ophthalmology
https://www.readbyqxmd.com/read/29862185/vessel-density-in-oct-angiography-permits-differentiation-between-normal-and-glaucomatous-optic-nerve-heads
#2
Claudia Lommatzsch, Kai Rothaus, Joerg Michael Koch, Carsten Heinz, Swaantje Grisanti
AIM: To evaluate whether optical coherence tomography angiography (OCTA) can detect altered vessel density (VD) at the optic nerve head (ONH) in glaucoma patients. Special attention is paid to the accuracy of the OCTA technique for distinguishing healthy from glaucomatous eyes. METHODS: A total of 171 eyes were examined by the OCTA system AngioVue™ (Optovue): 97 eyes diagnosed with glaucoma and 74 healthy control eyes. The papillary and peripapillary VD was measured...
2018: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/29861577/application-of-optical-coherence-tomography-in-the-detection-and-classification-of-cognitive-decline
#3
REVIEW
Moon J Lee, Alison G Abraham, Bonnielin K Swenor, A Richey Sharrett, Pradeep Y Ramulu
Aim: This review aims to critically analyze the current literature on the relationship of optical coherence tomography (OCT) measures to cognition and dementia. Background: Optical coherence tomography, a noninvasive method of imaging neuroretinal layers, and OCT angiography, a highly precise method of examining retinal vasculature, have widely been used to aid in the diagnosis and monitoring of a variety of ocular diseases. There is now an increasing body of evidence relating the structural and microvascular changes of the retina to cognitive impairment...
January 2018: Journal of Current Glaucoma Practice
https://www.readbyqxmd.com/read/29859144/microstructure-of-parapapillary-atrophy-is-associated-with-parapapillary-microvasculature-in-myopic-eyes
#4
Mi Sun Sung, Hwan Heo, Sang Woo Park
PURPOSE: To evaluate the clinical characteristics of β-PPA in myopic eyes and determine whether the microstructure of β-PPA is associated with parapapillary microvasculature by using optical coherence tomography (OCT) angiography. DESIGN: Cross-sectional study METHODS: This study included 80 subjects with myopia with β-PPA. Spherical equivalent (SE) refractive error, axial length, horizontal tilt angle, and the width of β-PPA were evaluated. The microstructure of β-PPA and subfoveal choroidal thickness were evaluated using enhanced-depth imaging OCT and eyes were classified into 3 groups based on the presence of Bruch's membrane (BM), a PPA+BM only group, a PPA+BM and PPA-BM group, and a PPA-BM only group...
May 30, 2018: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/29858182/relationship-between-vessel-density-and-visual-field-sensitivity-in-glaucomatous-eyes-with-high-myopia
#5
Joong Won Shin, Junki Kwon, Jiyun Lee, Michael S Kook
AIMS: To investigate the global and regional relationships between peripapillary vessel density (pVD) and visual field mean sensitivity (VFMS) in glaucomatous eyes with and without high myopia in comparison with those between peripapillary retinal nerve fibre layer thickness (pRNFLT) and VFMS. METHODS: A total of 130 eyes from 130 patients with glaucoma consisting of those with and without high myopia were included in a consecutive manner. High myopia was defined as a spherical equivalent <-6...
June 1, 2018: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/29852029/optical-coherence-tomography-angiography-compared-with-optical-coherence-tomography-macular-measurements-for-detection-of-glaucoma
#6
Kelvin H Wan, Alexander K N Lam, Christopher Kai-Shun Leung
Importance: Whether optical coherence tomography angiography (OCT-A) outperforms OCT to detect glaucoma remains inconclusive. Objective: To compare (1) the diagnostic performance for detection of glaucoma and (2) the structure-function association between inner macular vessel density and inner macular thickness. Design, Setting, and Participants: This cross-sectional study included 115 patients with glaucoma and 35 healthy individuals for measurements of retinal thickness and retinal vessel density, segmented between the anterior boundary of internal limiting membrane and the posterior boundary of the inner plexiform layer, over the 3 × 3-mm2 macula using swept-source OCT...
May 31, 2018: JAMA Ophthalmology
https://www.readbyqxmd.com/read/29794471/optical-coherence-tomography-angiography-in-glaucoma-a-review
#7
Lukas Van Melkebeke, João Barbosa-Breda, Marc Huygens, Ingeborg Stalmans
BACKGROUND: Glaucoma is the leading cause of irreversible blindness worldwide. Several techniques exist for the diagnosis and follow-up of patients. Optical coherence tomography (OCT) angiography (OCTA) is a recently developed technique that provides a quantitative assessment of the microcirculation of the retina and choroid in a fast, noninvasive way. Despite it being a novel technique, several publications have already been done in the glaucoma field. However, a summary of findings is currently lacking...
May 24, 2018: Ophthalmic Research
https://www.readbyqxmd.com/read/29762268/influence-of-removing-the-large-retinal-vessels-related-effect-on-peripapillary-vessel-density-progression-analysis-in-glaucoma
#8
Gábor Holló
PURPOSE: To investigate the usefulness of removing the large vessel-related information from peripapillary optical coherence tomography (OCT) angiography progression analysis. Peripapillary vessel density (VD) image series which had shown no progression with an earlier software version that did not separate capillary and large vessel-related effects were reevaluated for selective peripapillary capillary VD progression. METHODS: Prospective retinal nerve fiber layer thickness (RNFLT) and peripapillary VD measurements were made using the Angiovue/RTvue-XR OCT on one eye of 9 normal, 20 under treatment ocular hypertensive (OHT) and 24 under treatment open-angle glaucoma patients at 6-month intervals for 2 years (5 visits)...
May 12, 2018: Journal of Glaucoma
https://www.readbyqxmd.com/read/29757019/optical-coherence-tomography-angiography-in-glaucoma-care
#9
Sunee Chansangpetch, Shan C Lin
Rapid improvements in optical coherence tomography (OCT) technology have allowed for enhancement of both image resolution and scanning speed, and the development of vascular assessment modality. Optical coherence tomography angiography (OCTA) is the non-invasive in vivo imaging of the vasculature located within the retina and optic nerve head area. The principle of OCTA is to use the variations in OCT signals caused by moving particles as the contrast mechanism for imaging of flow. Several algorithms which aim to maximize the contrast signal and minimize the noise have been developed including the phase-based techniques, intensity-based techniques (e...
May 14, 2018: Current Eye Research
https://www.readbyqxmd.com/read/29747355/-analysis-on-the-clinical-and-retinal-imaging-characteristics-of-autosomal-recessive-bestrophinopathy
#10
Q Li, X Y Peng, X N Wang, Y Li, L Tian
Objective: To study the clinical and imaging features of autosomal recessive bestrophinopathy (ARB). Methods: Retrospective study. The clinical and imaging data of 14 participants were analyzed in using autofluorescence (AF), fluorescein angiography (FA) and spectral-domain optical coherence tomography (SD-OCT). Ten patients were screened for mutations in BEST1 gene. Results: Retinopathy of ARB were shown as bilaterally and circularly distributed yellow subretinal deposits in the mid-peripheral and posterior retina, which was observed more clearly by AF and FA...
April 11, 2018: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://www.readbyqxmd.com/read/29664832/optical-coherence-tomography-angiography-macular-vascular-density-measurements-and-the-central-10-2-visual-field-in-glaucoma
#11
Rafaella C Penteado, Linda M Zangwill, Fábio B Daga, Luke J Saunders, Patricia I C Manalastas, Takuhei Shoji, Tadamichi Akagi, Mark Christopher, Adeleh Yarmohammadi, Sasan Moghimi, Robert N Weinreb
PURPOSE: To evaluate the association between macula vascular density assessed by optical coherence tomography angiography (OCT-A) and central visual field (VF) threshold sensitivities in healthy, glaucoma suspect, and glaucoma patients. METHODS: A total of 185 eyes from 38 healthy participants, 31 glaucoma suspects, 72 mild glaucoma patients, and 44 moderate/severe glaucoma patients from the Diagnostic Innovations in Glaucoma Study who underwent OCT-A images of the macula and 10-2 VF testing were enrolled in this observational cross-sectional study...
June 2018: Journal of Glaucoma
https://www.readbyqxmd.com/read/29651340/changes-in-flow-density-measured-using-optical-coherence-tomography-angiography-after-istent-insertion-in-combination-with-phacoemulsification-in-patients-with-open-angle-glaucoma
#12
Maged Alnawaiseh, Viktoria Müller, Larissa Lahme, Ralph Laurent Merté, Nicole Eter
Purpose: To evaluate changes in flow density after the implantation of a trabecular microbypass stent (iStent) in combination with cataract surgery. Methods: A total of 48 eyes of 48 patients, who underwent either cataract surgery alone (cataract group) or cataract surgery with implantation of two iStent inject devices (iStent group), were prospectively included in this study. Intraocular pressure (IOP) and flow density data before and after surgery were extracted and analyzed...
2018: Journal of Ophthalmology
https://www.readbyqxmd.com/read/29651339/comparison-of-optical-coherence-tomography-angiography-and-laser-speckle-flowgraphy-for-the-diagnosis-of-normal-tension-glaucoma
#13
Asuka Takeyama, Kyoko Ishida, Ayako Anraku, Masahiro Ishida, Goji Tomita
Purpose: To compare optical coherence tomography angiography (OCT-A) and laser speckle flowgraphy (LSFG) for the diagnosis of normal-tension glaucoma (NTG). Methods: Twenty-eight eyes of 28 patients with NTG and 25 eyes of 25 normal subjects matched for age, refractive errors, systemic blood pressure, and central corneal thickness were evaluated. OCT-A was used to measure whole image vessel density, inside disc vessel density, and peripapillary vessel density; using LSFG, mean blur rate (MBR) inside the whole optic nerve head (ONH) area (MBRA ), and MBR of the vessel area (MBRV ) and tissue area (MBRT ) inside the ONH, were determined...
2018: Journal of Ophthalmology
https://www.readbyqxmd.com/read/29613982/association-between-the-deep-layer-microvasculature-dropout-and-the-visual-field-damage-in-glaucoma
#14
Min Hee Suh, Jun Woo Park, Hae Rang Kim
PURPOSE: To compare the visual field (VF) sensitivity according to the presence of parapapillary deep-layer microvasculature dropout (MvD_P) and focal lamina cribrosa (LC) defect. MATERIALS AND METHODS: Among 158 open-angle glaucoma patients, 4 groups were formed according to the presence of MvD_P and focal LC defect determined by optical coherence tomography (OCT) angiography and by enhanced depth imaging spectral-domain OCT, respectively: (1) eyes without either focal LC defect or MvD_P (group 1); (2) eyes with focal LC defect but no MvD_P (group 2); (3) eyes without focal LC defect but with MvD_P (group 3); (4) eyes with both focal LC defect and MvD_P (group 4)...
June 2018: Journal of Glaucoma
https://www.readbyqxmd.com/read/29580976/inter-eye-asymmetry-of-optical-coherence-tomography-angiography-vessel-density-in-bilateral-glaucoma-glaucoma-suspect-and-healthy-eyes
#15
Huiyuan Hou, Sasan Moghimi, Linda M Zangwill, Takuhei Shoji, Elham Ghahari, Patricia Isabel C Manalastas, Rafaella C Penteado, Robert N Weinreb
PURPOSE: To investigate inter-eye retinal vessel density asymmetry in healthy, glaucoma suspect, and mild-to-moderate glaucoma subjects, and its potential utility for early detection of glaucomatous damage. DESIGN: Cross-sectional study. METHODS: In 153 subjects including 55 healthy, 32 glaucoma suspect, and 66 glaucoma subjects enrolled in the Diagnostic Innovations in Glaucoma Study (DIGS), vessel density was obtained from optical coherence tomography angiography (OCT-A) macular and optic nerve head scans...
June 2018: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/29520478/increase-in-the-oct-angiographic-peripapillary-vessel-density-by-rock-inhibitor-ripasudil-instillation-a-comparison-with-brimonidine
#16
Etsuo Chihara, Galina Dimitrova, Tomoyuki Chihara
PURPOSE: To assess the responses of the superficial peripapillary retinal vessel density (VD) and prelaminar flow index (PLFI) to topical Rho-assisted coiled-coil forming protein kinase (ROCK) inhibitor ripasudil and alpha-2 agonist brimonidine using optical coherence tomography angiography. METHODS: This is a prospective, non-randomized, comparative cohort study. We studied the response of optical coherence tomography angiography (OCTA) parameters to drugs in 24 eyes treated with ripasudil and 23 eyes treated with brimonidine at the Sensho-kai Eye Institute...
March 8, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/29486903/choroidal-microvasculature-dropout-is-associated-with-progressive-retinal-nerve-fiber-layer-thinning-in-glaucoma-with-disc-hemorrhage
#17
Hae-Young Lopilly Park, Jin Woo Kim, Chan Kee Park
OBJECTIVE: We used OCT angiography (OCT-A) to investigate parapapillary choroidal microvasculature dropout (MvD) in glaucomatous eyes with or without disc hemorrhage (DH), and the association with changes in retinal nerve fiber layer (RNFL) thickness. DESIGN: An observational case-control study. PARTICIPANTS: Eighty-two open-angle glaucoma (OAG) eyes with DH and 68 OAG eyes without DH that underwent at least 4 serial OCT examinations were included...
February 24, 2018: Ophthalmology
https://www.readbyqxmd.com/read/29462016/diurnal-variations-of-peripapillary-and-macular-vessel-density-in-glaucomatous-eyes-using-optical-coherence-tomography-angiography
#18
Kaweh Mansouri, Harsha L Rao, Kirsten Hoskens, Elisa D'Alessandro, Elsa M Flores-Reyes, André Mermoud, Robert N Weinreb
PURPOSE: The purpose of this study was to investigate the diurnal variation in peripapillary and macular vessel density (VD) measurements using optical coherence tomographic angiography (OCT-A) and its correlation to intraocular pressure (IOP) changes in glaucoma patients. METHODS: Prospective, observational cross-sectional study including 37 patients (74 eyes; age, 63.8±12.9 y) with open-angle glaucoma. OCT-A imaging and IOP measurements were performed at 08:00, 11:00, 14:00, and 16:00 timepoints on a single day...
April 2018: Journal of Glaucoma
https://www.readbyqxmd.com/read/29462015/macular-vessel-density-in-glaucomatous-eyes-with-focal-lamina-cribrosa-defects
#19
Elham Ghahari, Christopher Bowd, Linda M Zangwill, Min Hee Suh, Takuhei Shoji, Kyle A Hasenstab, Luke J Saunders, Sasan Moghimi, Huiyuan Hou, Patricia I C Manalastas, Rafaella C Penteado, Robert N Weinreb
PURPOSE: To compare optical coherence tomography angiography (OCTA) measured macular vessel density and spectral domain optical coherence tomography (SDOCT) measured macular ganglion cell complex (GCC) thickness in primary open-angle glaucoma eyes with and without focal lamina cribrosa (LC) defects. METHODS: In this cross-sectional, case-control study of patients with primary open-angle glaucoma, 46 eyes of 46 patients with LC defects and 54 eyes of 54 patients without observable LC defects were included...
April 2018: Journal of Glaucoma
https://www.readbyqxmd.com/read/29409880/the-effects-of-graded-intraocular-pressure-challenge-on-the-optic-nerve-head
#20
Nimesh Patel, Faith McAllister, Laura Pardon, Ronald Harwerth
Intraocular pressure (IOP) is an important risk factor for glaucoma, and the response of the ONH and surrounding tissues to elevated IOP are often investigated to better understand pathophysiology. In vivo structure including that of the optic nerve head (ONH) and surrounding tissue of the eye are often assessed using optical coherence tomography (OCT). With advances in OCT technology, both large vessels and capillaries can be imaged non-invasively (OCT Angiography). Because a significant portion of retinal thickness is comprised of vasculature, the purpose of the current study was to investigate OCT structural and vascular changes in healthy non-human primate eyes with systematic graded increases and decreases in IOP...
April 2018: Experimental Eye Research
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