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Glaucoma OCT angiography

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https://www.readbyqxmd.com/read/29224927/central-visual-field-damage-and-parapapillary-choroidal-microvasculature-dropout-in-primary-open-angle-glaucoma
#1
Eun Ji Lee, Tae-Woo Kim, Ji-Ah Kim, Jeong-Ah Kim
PURPOSE: To determine whether microvasculature dropout (MvD) in the parapapillary choroid is related to the presence of central visual field defects in primary open-angle glaucoma (POAG). DESIGN: Cross-sectional observational study. PARTICIPANTS: Thirty-two POAG patients with an initial parafoveal scotoma (IPFS) within a 10° radius in 1 hemifield and 42 POAG patients with an initial nasal step (INS) within the nasal periphery outside 10° of fixation in 1 hemifield...
December 7, 2017: Ophthalmology
https://www.readbyqxmd.com/read/29199863/optical-coherence-tomography-based-scattering-properties-of-retinal-vessels-in-glaucoma-patients
#2
Robert Kromer, Sebastian Boelefahr, Brendan Eck, Shafin Rahman, Maren Klemm
PURPOSE: Clinical trials have demonstrated that retinal blood flow deficiencies are present in patients with open-angle glaucoma (OAG). We introduce a method for facilitating retinal vessel analysis: The intensity of the distal shadow of vessels in optical coherence tomography (OCT) caused by the scattered signal is analyzed, compared between healthy subjects and OAG patients and correlated with OCT angiography (OCT-A) flow density. PATIENTS AND METHODS: We recruited 80 patients with diagnosed OAG (mean age 63...
December 4, 2017: Current Eye Research
https://www.readbyqxmd.com/read/29183045/peripapillary-microvascular-improvement-and-lamina-cribrosa-depth-reduction-after-trabeculectomy-in-primary-open-angle-glaucoma
#3
Joong Won Shin, Kyung Rim Sung, Ki Bang Uhm, Jaehyuck Jo, Yeji Moon, Min Kyung Song, Ji Yoon Song
Purpose: To evaluate peripapillary microvascular changes in patients with primary open-angle glaucoma (POAG) after trabeculectomy using optical coherence tomography (OCT) angiography, and to determine the influence of lamina cribrosa (LC) displacement on changes in peripapillary microvasculature. Methods: The peripapillary retinal microvasculature and LC were imaged using OCT angiography and OCT-enhanced depth imaging, respectively. The microvasculature and LC depth (LCD) were measured before, and 1 week, 1 month, and 3 months after trabeculectomy...
November 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29174012/peripapillary-and-macular-vessel-density-in-patients-with-primary-open-angle-glaucoma-and-unilateral-visual-field-loss
#4
Adeleh Yarmohammadi, Linda M Zangwill, Patricia Isabel C Manalastas, Nathanael J Fuller, Alberto Diniz-Filho, Luke J Saunders, Min Hee Suh, Kyle Hasenstab, Robert N Weinreb
PURPOSE: To characterize OCT angiography (OCT-A) vessel density of patients with primary open-angle glaucoma (POAG) with unilateral visual field (VF) loss. DESIGN: Cross-sectional study. PARTICIPANTS: A total of 33 patients with POAG with a VF defect in 1 eye (mean VF mean deviation [MD], -3.9±3.1 decibels [dB]) and normal VF in the other eye (mean VF MD, -0.2±0.9 dB) and 33 healthy eyes. METHODS: All subjects underwent OCT-A imaging, spectral-domain (SD)-OCT imaging, and VF testing...
November 21, 2017: Ophthalmology
https://www.readbyqxmd.com/read/29171726/factors-associated-with-deep-circulation-in-the-peripapillary-chorioretinal-atrophy-zone-in-normal-tension-glaucoma-with-myopic-disc
#5
Naoki Kiyota, Hiroshi Kunikata, Seri Takahashi, Yukihiro Shiga, Kazuko Omodaka, Toru Nakazawa
PURPOSE: To investigate factors associated with choroidal microcirculation in the peripapillary chorioretinal atrophy (PPA) zone in eyes with normal-tension glaucoma (NTG) and myopic disc. METHODS: In 100 eyes of 100 NTG patients with myopic disc and 20 eyes of 20 age-matched myopic controls, 4.5 × 4.5 mm scans were made of the optic nerve head with optical coherence tomography angiography (OCTA). Peripapillary chorioretinal atrophy (PPA) area and PPA superficial choroidal image intensity (PPA-CI) were calculated with image j software...
November 24, 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/29140817/new-developments-in-optical-coherence-tomography-imaging-for-glaucoma
#6
Jean-Claude Mwanza, Donald L Budenz
PURPOSE OF REVIEW: Since its introduction in ophthalmology, optical coherence tomography (OCT) has undergone significant advances in imaging protocols, algorithms, and addition of new parameters which have maximized its potential for diagnosing, evaluating the response to treatment, and assessing the progression of various ocular diseases, including glaucoma. This review provides an update on recent developments in OCT with respect to the management of glaucoma. RECENT FINDINGS: Most recent notable developments include the introduction of the minimum distance band, which is a three-dimensional optic nerve head parameter, and Swept-Source OCT with its single wide-field scanning capability...
November 14, 2017: Current Opinion in Ophthalmology
https://www.readbyqxmd.com/read/29114838/optical-coherence-tomography-angiography-macular-and-peripapillary-vessel-perfusion-density-in-healthy-subjects-glaucoma-suspects-and-glaucoma-patients
#7
COMPARATIVE STUDY
Giacinto Triolo, Alessandro Rabiolo, Nathan D Shemonski, Ali Fard, Federico Di Matteo, Riccardo Sacconi, Paolo Bettin, Stephanie Magazzeni, Giuseppe Querques, Luis E Vazquez, Piero Barboni, Francesco Bandello
Purpose: To evaluate macular and peripapillary vessel perfusion density (VD) in glaucoma suspects (GS) and glaucoma patients; to correlate ganglion cell-inner plexiform layer (GCIPL) and retinal nerve fiber layer (RNFL) thicknesses with macular and peripapillary VD; and to evaluate the diagnostic accuracy of the structural and vascular parameters. Methods: A consecutive series of GS, glaucoma patients, and healthy subjects was prospectively recruited from July 1, 2016, to January 31, 2017...
November 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29101405/parapapillary-deep-layer-microvasculature-dropout-in-primary-open-angle-glaucoma-eyes-with-a-parapapillary-%C3%AE-zone
#8
Eun Ji Lee, Tae-Woo Kim, Ji-Ah Kim, Jeong-Ah Kim
Purpose: To explore the clinical characteristics of parapapillary deep-layer microvasculature dropout (MvD) associated with parapapillary γ-zone in primary open-angle glaucoma (POAG). Methods: A total of 150 eyes with POAG and 75 age- and axial length-matched control eyes, both having parapapillary γ-zone as determined by spectral-domain (SD) optical coherence tomography (OCT), were included. Parapapillary MvD was defined as a focal sectoral capillary dropout without any visible microvascular network identified in deep-layer en-face images obtained using swept-source OCT angiography (OCTA)...
November 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29101122/topographic-correlation-between-juxtapapillary-choroidal-thickness-and-parapapillary-deep-layer-microvasculature-dropout-in-primary-open-angle-glaucoma
#9
Seung Hyen Lee, Eun Ji Lee, Tae-Woo Kim
PURPOSE: To investigate the topographic relationship between parapapillary deep-layer microvasculature dropout (MvD) as assessed by optical coherence tomography (OCT) angiography (OCTA) and the juxtapapillary choroidal thickness (JPCT) in primary open-angle glaucoma (POAG). METHODS: A total of 194 eyes (138 POAG and 56 control eyes) having parapapillary atrophy (PPA) were imaged using the swept-source OCT and OCTA to examine the microstructure of PPA and measure the JPCT, and to determine the presence of the MvD...
November 3, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/29049726/comparison-of-sectoral-structure-function-relationships-in-glaucoma-vessel-density-versus-thickness-in-the-peripapillary-retinal-nerve-fiber-layer
#10
COMPARATIVE STUDY
Kimikazu Sakaguchi, Tomomi Higashide, Sachiko Udagawa, Shinji Ohkubo, Kazuhisa Sugiyama
Purpose: To compare the sectoral structure-function relationships in glaucoma between two structural parameters, vessel density (VD) and thickness, in the peripapillary retinal nerve fiber layer (RNFL). Methods: Optical coherence tomography (OCT) angiography (AngioVue/RTVue-XR) for VD and OCT (RS-3000) for peripapillary RNFL thickness were performed in 129 eyes from 129 subjects (94 glaucoma, 17 glaucoma suspects, and 18 normal eyes). Humphrey visual field (VF) tests were performed using a SITA standard 24-2 program...
October 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29049718/wide-field-oct-angiography-investigation-of-the-relationship-between-radial-peripapillary-capillary-plexus-density-and-nerve-fiber-layer-thickness
#11
Yali Jia, Joseph M Simonett, Jie Wang, Xiaohui Hua, Liang Liu, Thomas S Hwang, David Huang
Purpose: To characterize the density and distribution of the radial peripapillary capillary plexus (RPCP) and its relationship with retinal nerve fiber layer (NFL) thickness in healthy subjects. Methods: Using spectral-domain optical coherence tomography (OCT), split-spectrum amplitude decorrelation angiography algorithm and automated montaging, wide-field OCT angiography (OCTA) was used to measure the RPCP capillary density (CD) and NFL thickness. Polar sector-average CD and thickness maps were also created on each eye...
October 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28991833/optical-coherence-tomography-angiography-vessel-density-measurements-in-eyes-with-primary-open-angle-glaucoma-and-disc-hemorrhage
#12
Harsha L Rao, Zia S Pradhan, Robert N Weinreb, Srilakshmi Dasari, Mohammed Riyazuddin, Jayasree P Venugopal, Narendra K Puttaiah, Dhanaraj A S Rao, Sathi Devi, Kaweh Mansouri, Carroll A B Webers
PURPOSE: To compare the vessel density measurements of optic nerve head, peripapillary and macular regions in severity-matched primary open-angle glaucoma (POAG) eyes with and without disc hemorrhage (DH) using optical coherence tomography (OCT) angiography, and to compare their diagnostic abilities with that of the rim area, retinal nerve fiber layer and the ganglion cell complex thickness measurements on OCT. METHODS: In a cross-sectional study, 66 eyes of 46 control subjects, 34 eyes of 33 POAG patients with DH (median mean deviation=-3...
October 2017: Journal of Glaucoma
https://www.readbyqxmd.com/read/28934255/quantitative-optical-coherence-tomography-angiography-of-macular-vascular-structure-and-foveal-avascular-zone-in-glaucoma
#13
Jaewan Choi, Junki Kwon, Joong Won Shin, Jiyun Lee, Saem Lee, Michael S Kook
OBJECTIVE: The study aimed to evaluate the quantitative characteristics of the macular vessel density (VD) and foveal avascular zone (FAZ) in glaucoma using optical coherence tomography angiography (OCT-A). DESIGN: Cross-sectional, age- and sex-matched case-control study. METHODS: Fifty-two eyes of 52 patients with primary open angle glaucoma and 52 eyes from 52 healthy participants were recruited retrospectively. OCT-A was performed on a 3 x 3-mm macular region centered on the fovea...
2017: PloS One
https://www.readbyqxmd.com/read/28928966/optical-coherence-tomography-angiography-in-glaucoma-a-mini-review
#14
REVIEW
Kelvin H Wan, Christopher K S Leung
The advent of optical coherence tomography angiography (OCT-A) provides a new opportunity to visualize the retinal vasculature in a non-invasive and dye-free manner which may help identify vascular abnormalities in glaucoma. While a reduction in retinal and optic nerve head vessel densities and blood flow indexes measured by OCT-A has been demonstrated in patients with glaucoma in many studies, it is unclear whether OCT-A provides additional information for the detection and monitoring of glaucoma compared with OCT measurements such as retinal nerve fiber layer thickness, neuroretinal rim width, and ganglion cell inner plexiform layer thickness...
2017: F1000Research
https://www.readbyqxmd.com/read/28924335/optical-coherence-tomography-angiography-to-better-understand-glaucoma
#15
EDITORIAL
Gábor Holló
The term optical coherence tomography angiography (OCTA) comprises different OCT-based technologies which all allow noninvasive assessment of retinal perfusion, based on moving red blood cells. The main areas where OCTA is currently used are investigation of perfusion and vascular structure of the macular retina (e.g., in macular degenerations and diabetic macular diseases) and the disk and peripapillary retina (in glaucoma and other optic disk diseases). The current editorial provides a brief overview on the potential of OCTA and its use to measure perfusion in the peripapillary retina in glaucoma...
May 2017: Journal of Current Glaucoma Practice
https://www.readbyqxmd.com/read/28915256/optical-coherence-tomography-angiography-of-the-peripapillary-capillaries-in-primary-open-angle-and-normal-tension-glaucoma
#16
Ryoko Igarashi, Shun Ochiai, Yuta Sakaue, Aki Suetake, Ryu Iikawa, Testuya Togano, Fuuko Miyamoto, Daiki Miyamoto, Takeo Fukuchi
OBJECTIVES: To evaluate the vascular architecture of the radial peripapillary capillaries (RPCs) and its relation with visual function in patients with open-angle glaucoma (OAG) and normal-tension glaucoma using spectral-domain optical coherence tomography (SD-OCT) angiography. SUBJECTS AND METHODS: Clear OCT angiography images of blood vessels in the optic disc and peripapillary retina were obtained from 52 patients (52 eyes) aged 55.42±10.64 (range 28-72) years with primary OAG...
2017: PloS One
https://www.readbyqxmd.com/read/28910159/glaucoma-diagnostic-ability-of-the-optical-coherence-tomography-angiography-vessel-density-parameters
#17
Jae Keun Chung, Young Hoon Hwang, Jae Min Wi, Mijin Kim, Jong Jin Jung
PURPOSE: To investigate the glaucoma diagnostic abilities of vessel density parameters as determined by optical coherence tomography (OCT) angiography in different stages of glaucoma. MATERIALS AND METHODS: A total of 113 healthy eyes and 140 glaucomatous eyes were enrolled. Diagnostic abilities of the OCT vessel density parameters in the optic nerve head (ONH), peripapillary, and macular regions were evaluated by calculating the area under the receiver operation characteristic curves (AUCs)...
November 2017: Current Eye Research
https://www.readbyqxmd.com/read/28859176/comparison-of-peripapillary-vessel-density-between-preperimetric-and-perimetric-glaucoma-evaluated-by-oct-angiography
#18
Si Bum Kim, Eun Jung Lee, Jong Chul Han, Changwon Kee
PURPOSE: To determine peripapillary vessel density in eyes with perimetric glaucoma (PG) or preperimetric glaucoma (PPG) compared to normal controls using optical coherence tomography-angiography (OCT-A). METHODS: We recruited 13 patients with unilateral perimetric normal-tension glaucoma (NTG) and fellow preperimetric NTG showing only inferotemporal retinal nerve fiber layer (RNFL) defect in red-free RNFL photography in both eyes. We also enrolled 9 healthy controls...
2017: PloS One
https://www.readbyqxmd.com/read/28858159/reproducibility-of-optical-coherence-tomography-angiography-macular-and-optic-nerve-head-vascular-density-in-glaucoma-and-healthy-eyes
#19
Patricia I C Manalastas, Linda M Zangwill, Luke J Saunders, Kaweh Mansouri, Akram Belghith, Min Hee Suh, Adeleh Yarmohammadi, Rafaella C Penteado, Tadamichi Akagi, Takuhei Shoji, Robert N Weinreb
PURPOSE: Optical coherence tomography angiography (OCT-A) is a noninvasive technology that allows visualization of retinal blood vessels. It is important to determine reproducibility of measurements as low precision can impair its diagnostic capabilities. The purpose of this study is to determine intravisit and intervisit reproducibility of optic nerve head (ONH) and macular vessel density measurements with OCT-A. PATIENTS AND METHODS: Fifteen healthy volunteers and 14 glaucoma patients completed 2 OCT-A (AngioVue; Optovue Inc...
October 2017: Journal of Glaucoma
https://www.readbyqxmd.com/read/28797550/optical-coherence-tomography-angiography-of-the-peripapillary-retina-in-primary-angle-closure-glaucoma
#20
Shunhua Zhang, Chan Wu, Liang Liu, Yali Jia, Yao Zhang, Yang Zhang, Hua Zhang, Yong Zhong, David Huang
PURPOSE: To measure the change of peripapillary retinal vessel density (VD) in eyes with a history of acute primary angle-closure glaucoma (PACG). DESIGN: Case-control study. METHODS: Twenty-one consecutive Chinese patients with history of unilateral acute PACG were enrolled. Eyes with acute PACG constituted the case group, while the contralateral eyes without attack constituted the control. All patients underwent ophthalmic examinations including best-corrected visual acuity, intraocular pressure, and visual field (VF)...
October 2017: American Journal of Ophthalmology
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