keyword
https://read.qxmd.com/read/37900897/tetrahydrocannabinol-in-pediatrics-room-for-improvement
#21
JOURNAL ARTICLE
Charlotte de Gier, Christian Scharinger, Rosa H Stark, Philipp Steurer, Claudia M Klier
INTRODUCTION: The use of medical cannabis in pediatrics is not common in clinical practice, and there is a lack of prospective studies, especially in pediatric subpopulations. This study aimed to provide data on the off-label administration of tetrahydrocannabinol (∆9-THC) in a pediatric tertiary center in Austria. METHODS: A retrospective data analysis was performed to assess the use of ∆9-THC at the Department of Pediatrics and Adolescent Medicine at the Comprehensive Center of Pediatrics (Medical University Vienna) from 2016 to 2018...
2023: Medical cannabis and cannabinoids
https://read.qxmd.com/read/37897816/prognostic-scoring-system-for-surgical-treatment-of-intramedullary-spinal-cord-metastases
#22
JOURNAL ARTICLE
Roberto Gazzeri, Stefano Telera, Marcelo Galarza, Isabella Sperduti, Alex Alfieri
Although rare, intramedullary spinal cord metastases (ISCMs) are on the rise, most likely due to prolonged survival and improved outcomes as a result of the advances in cancer treatment for cancer patients. While the management of these lesions remains controversial, surgery for ISCM has recently been advocated for selected patients. We performed a retrospective analysis on 30 patients who were surgically treated for intramedullary spinal cord metastases in order to determine a preoperative prognostic scoring system to guide patient selection for surgical interventions...
October 26, 2023: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://read.qxmd.com/read/37883725/radiotherapy-for-brain-metastases-near-the-end-of-life-characterizing-patients-and-tumor-features
#23
JOURNAL ARTICLE
Saulo Brito Silva, Rafael Balsini Barreto, Fernanda Cristina Gonçalves de Oliveira, Gabriela Schmidt Defende Martin, Ofelia Maria Yukie Takiguchi, Iasmin Alves Chirichela, Mário Henrique Furlanetto Miranda, Denize Bodnar, Luiz Augusto Alves Reis, Gabriel Clemente Brito Pereira, Isabela Lacerda Miranda, Bruno Rodriguez Pereira, Gustavo Viani Arruda, Fernanda Maris Peria
PURPOSE: Patients with brain metastases are often referred for brain radiotherapy (BrRT) when exclusive palliative management would be more appropriate. To assess the indication of BrRT during end-of-life (EOL) care and evaluate the characteristics of the patients who underwent the treatment. METHODS: This retrospective study comprised patients from four independent oncology centers who had undergone BrRT for metastases. The variables included were Karnofsky performance status (KPS), primary tumor site, metastatic status, neurologic symptomatic status, the number and size of metastases, posterior fossa or meningeal involvement, type of BrRT, having undergone brain metastasectomy, and the availability of systemic therapies after BrRT...
September 2023: JCO global oncology
https://read.qxmd.com/read/37856136/unforeseen-gifts-seeking-meaning-while-caring-for-children-diagnosed-with-dipg
#24
JOURNAL ARTICLE
Megan R Schaefer
No abstract text is available yet for this article.
October 19, 2023: Pediatric Blood & Cancer
https://read.qxmd.com/read/37787999/intratumoral-delivery-of-chimeric-antigen-receptor-t-cells-targeting-cd133-effectively-treats-brain-metastases
#25
JOURNAL ARTICLE
Agata M Kieliszek, Daniel Mobilio, Deepak Upreti, Darin Bloemberg, Laura Escudero, Jacek M Kwiecien, Zahra Alizada, Kui Zhai, Patrick Ang, Shawn C Chafe, Parvez Vora, Chitra Venugopal, Sheila K Singh
PURPOSE: Brain metastases (BM) are mainly treated palliatively with an expected survival of less than 12 months post-diagnosis. In many solid tumors, the human neural stem cell marker glycoprotein CD133 is a marker of a tumor-initiating cell population that contributes to therapy resistance, relapse, and metastasis. EXPERIMENTAL DESIGN: Here, we use a variant of our previously described CD133 binder to generate second generation CD133-specific chimeric antigen receptor T cells (CAR-T) to demonstrate its specificity and efficacy against multiple patient-derived BM cell lines with variable CD133 antigen expression...
October 3, 2023: Clinical Cancer Research
https://read.qxmd.com/read/37786226/patient-free-simulation-analysis-of-hospitalized-patients-treated-without-ct-simulation
#26
JOURNAL ARTICLE
E M Davies, K L Stephans, A Novak, E J Murray, W Vuong, S S Kilic, A Halima, J H Suh, S R Campbell
PURPOSE/OBJECTIVE(S): Palliative radiation therapy (RT) can be a necessary element of treatment for hospitalized cancer patients who may be critically ill. We have implemented patient-free simulation machine starts using existing diagnostic imaging for treatment planning, eliminating the need for simulation. We hypothesize machine starts reduce time in the department without detriment to clinical outcomes. MATERIALS/METHODS: An IRB-approved database of patients receiving RT was queried for hospitalized patients treated with a machine start...
October 1, 2023: International Journal of Radiation Oncology, Biology, Physics
https://read.qxmd.com/read/37785768/temporal-incidence-and-patterns-of-distant-failure-for-human-papillomavirus-hpv-related-oropharyngeal-cancer
#27
JOURNAL ARTICLE
J Gaffney, A Ramzan, T Dinizulu, D O Onamusi, G Motamedi-Ghahfarokhi, H Mistry, G Price, K Garcez, C Hughes, D D Thomson, L W Lee, Y Jain, J M Price, A McPartlin
PURPOSE/OBJECTIVE(S): HPV related oropharyngeal cancer (HPV-OPC) enjoys improved treatment outcomes relative to non-HPV related disease but suffers from similar rates of distant metastases (DM) following treatment. Emerging data supports radical intent therapy for oligometastatic relapsed HPV-OPC, suggesting early diagnosis of DM may be beneficial to outcome. We assess temporal patterns in distance relapse to investigate rationalization of post treatment imaging. MATERIALS/METHODS: A retrospective single center cohort study was carried out of consecutive HPV-OPC treated with radical intent (chemo)radiotherapy ((CT)RT) between 2011 and 2020...
October 1, 2023: International Journal of Radiation Oncology, Biology, Physics
https://read.qxmd.com/read/37784892/patient-reported-outcomes-following-palliative-whole-brain-radiation-therapy-in-patients-with-brain-metastasis
#28
JOURNAL ARTICLE
B C Adegboyega, A O Joseph, O A Alabi, J Omomila, L Ngema, V Ainsworth, J Chin, W Ngwa
PURPOSE/OBJECTIVE(S): Brain metastases (BM) are a common occurrence in patients with advanced cancers, and extremely challenging to treat, resulting in short survival periods. Consequently, whole brain radiation therapy (WBRT) remains the standard palliative intervention for patients with BM. The present study set to evaluate the efficacy of WBRT by assessing the quality of life (QoL) and survival outcomes in WBRT-treated patients with BM. It was hypothesized that the WBRT would enhance the QoL through alleviation of symptoms and functionality, and prolong patient survival...
October 1, 2023: International Journal of Radiation Oncology, Biology, Physics
https://read.qxmd.com/read/37784656/palliative-whole-brain-radiotherapy-international-state-of-practice-2022
#29
JOURNAL ARTICLE
E Keit, S F Lee, M Woodward, K Shiue, I Desideri, E Oldenburger, M Beinz, M B Agyeman, M Theodorou, M Froid, C B Simone, H H M Yu, J Yarney, A Rembielak, D Rades, P Hoskin, P A S Johnstone
PURPOSE/OBJECTIVE(S): Increasing technology of radiation treatment planning and delivery, better systemic therapies, and randomized trials in the population of patients (pts) with brain metastases have provided robust targeted options. This has resulted in palliative whole brain radiation therapy (WBRT) being used far less frequently than previously. Most centers preferentially use stereotactic radiation surgery (SRS) for pts with several lesions and may reserve WBRT for those with poor performance, with rapidly progressive disease, or with leptomeningeal presentation...
October 1, 2023: International Journal of Radiation Oncology, Biology, Physics
https://read.qxmd.com/read/37784649/quality-of-palliative-radiation-therapy-assessed-using-quality-indicators-a-multicenter-survey
#30
JOURNAL ARTICLE
T Saito, N Shikama, T Takahashi, N Nakamura, H Aoyama, K Nakajima, M Koizumi, S Sekii, T Ebara, H Kiyohara, K Higuchi, A Yorozu, T Nishimura, Y Ejima, H Harada, N Araki, M Miwa, K Yamada, T Kawamoto, H Onishi, N Imano
PURPOSE/OBJECTIVE(S): Clinical practice is not always performed in accordance with guideline recommendations. Quality indicators (QIs) are valuable tools for evaluating the quality of healthcare systems. We sought to identify potential gaps between clinical practice and evidence using QIs previously developed using a modified Delphi method. MATERIALS/METHODS: We used seven QIs (Table 1) to assess the quality of radiation therapy for bone (BoM) and brain metastases (BrM) at 29 centers; 13 (45%) were academic (12 university hospitals and 1 cancer center) and 16 (55%) were nonacademic hospitals...
October 1, 2023: International Journal of Radiation Oncology, Biology, Physics
https://read.qxmd.com/read/37753318/hospice-and-palliative-care-for-patients-in-the-intensive-care-unit-current-status-in-countries-other-than-korea
#31
JOURNAL ARTICLE
Minkyu Jung
Although most patients prefer dying at home, patients whose condition rapidly becomes critical need care in the intensive care unit (ICU), and it is rare for them to die at home with their families. Therefore, interest in hospice and palliative care for patients in the ICU is increasing. Hospice and palliative care (PC) is necessary for all patients with life-threatening diseases. The following patients need palliative care in the ICU: patients with chronic critical illnesses who need tracheostomy, percutaneous gastrostomy tube, and extracorporeal life support; patients aged 80 years or older; stage 4 cancer patients; patients with specific acute diseases with a poor prognosis (e...
March 1, 2023: J Hosp Palliat Care
https://read.qxmd.com/read/37751050/palliative-care-in-neuro-oncology-an-update
#32
REVIEW
John Y Rhee, Sumita Strander, Alyx Podgurski, Daniel Chiu, Kate Brizzi, Deborah A Forst
PURPOSE OF REVIEW: While the benefits of palliative care for patients with cancer are well established, palliative care in neuro-oncology is still in its early stages. However, in recent years, there has been increasing attention drawn to the need for better palliative care for patients with brain tumors. RECENT FINDINGS: There is a growing body of literature demonstrating the high symptom burden and significant supportive care and information needs of these patients and their caregivers...
September 26, 2023: Current Neurology and Neuroscience Reports
https://read.qxmd.com/read/37679652/frequency-of-social-burden-and-underage-children-in-neuro-oncological-patients
#33
JOURNAL ARTICLE
Marcel A Kamp, Christiane von Sass, Donjetë Januzi, Maxine Dibué, Katharina Libourius, Anna C Lawson McLean, Peter Baumgarten, Aaron Lawson McLean, Nazife Dinc, Christian A Senft
OBJECTIVE: Brain tumours can cause significant burden for patients and their families, including physical, psychological, and social challenges. This burden can be particularly difficult for patients with malignant brain tumours and those with underage children. However, the frequency of social burden among neuro-oncological patients and the proportion of patients with underaged children is currently unknown. The aim of this retrospective study is to determine the frequency of social and family dysfunction among neuro-oncological patients, the percentage of such patients who have underage children, and to assess their associated burden...
September 7, 2023: Journal of Cancer Research and Clinical Oncology
https://read.qxmd.com/read/37646983/palliative-care-for-children-with-central-nervous-system-tumors-results-of-a-spanish-multicenter-study
#34
JOURNAL ARTICLE
Maria Pérez-Torres Lobato, Lucía Navarro-Marchena, Iñigo de Noriega, Miriam Morey Olivé, Palma Solano-Páez, Eloísa Rubio Pérez, Carmen Garrido Colino, Miriam García Abos, María Tallón García, Beatriz Huidobro Labarga, Raquel Portugal Rodríguez, Blanca López Ibor, Álvaro Lassaletta, Andrés Morgenstern Isaak, Ofelia Cruz Martínez, Lorena Valero Arrese, Anna Llort Sales, Luis Gros Subias, Catalina Márquez Vega, Lucas Moreno, Eduardo Quiroga-Cantero
BACKGROUND: Brain tumors represent the most common cause of cancer-related death in children. Few studies concerning the palliative phase in children with brain tumors are available. OBJECTIVES: (i) To describe the palliative phase in children with brain tumors; (ii) to determine whether the use of palliative sedation (PS) depends on the place of death, the age of the patient, or if they received specific palliative care (PC). METHODS: Retrospective multicenter study between 2010 and 2021, including children from one month to 18 years, who had died of a brain tumor...
August 30, 2023: Clinical & Translational Oncology
https://read.qxmd.com/read/37634617/european-cancer-organisation-essential-requirements-for-quality-cancer-care-adult-glioma
#35
EDITORIAL
Alessandro Bozzao, Damien Weber, Simon Crompton, Graça Braz, Dégi Csaba, Frederic Dhermain, Gaetano Finocchiaro, Thomas Flannery, Christof Kramm, Ian Law, Gianluca Marucci, Kathy Oliver, Christoph Ostgathe, Rosina Paterra, Gianfranco Pesce, Marion Smits, Riccardo Soffietti, Robert Terkola, Colin Watts, Alberto Costa, Philip Poortmans
European Cancer Organisation Essential Requirements for Quality Cancer Care (ERQCCs) are explanations of the organisation and actions necessary to provide high-quality care to patients with a specific cancer type. They are compiled by a working group of European experts representing disciplines involved in cancer care, and provide oncology teams, patients, policymakers and managers with an overview of the essential requirements in any healthcare system. The focus here is on adult glioma. Gliomas make up approximately 80% of all primary malignant brain tumours...
August 25, 2023: Journal of Cancer Policy
https://read.qxmd.com/read/37606711/-chemobrain-in-childhood-cancer-survivors-the-impact-on-social-academic-and-daily-living-skills-a-qualitative-systematic-review
#36
REVIEW
Ines Semendric, Danielle Pollock, Olivia J Haller, Rebecca P George, Lyndsey E Collins-Praino, Alexandra L Whittaker
PURPOSE: To examine children's experiences of chemotherapy-induced cognitive impairment--colloquially "chemobrain"--and the impact on children's social, academic, and daily living skills via a qualitative systematic review. Experiencing chemotherapy as a child, when the brain is still developing, may cause lifelong detriment to survivors' lives. There is a significant gap in understanding their lived experience, including the self-identified barriers that children face following treatment...
August 22, 2023: Supportive Care in Cancer
https://read.qxmd.com/read/37539468/exploring-the-experience-of-a-cognitive-rehabilitation-intervention-for-cancer-related-cognitive-change-in-people-living-with-cancer-an-interpretative-phenomenological-analysis
#37
JOURNAL ARTICLE
Andrea Joyce, Lindsey Burns, Kareena McAloney-Kocaman
OBJECTIVES: Some cancer patients experience cancer-related cognitive change (CRCC). Cognitive rehabilitation interventions (CRIs) have recently been developed to help mitigate the impact of CRCC, which, untreated, can impact resumption of daily life post-cancer treatment. The experience of participants is important to understand but largely absent within research literature. This study aimed to explore how those with CRCC experience the phenomenon following completion of a CRI. METHODS: This study comprised a qualitative phenomenological approach...
August 4, 2023: Palliative & Supportive Care
https://read.qxmd.com/read/37500926/prospective-randomized-clinical-studies-involving-reirradiation-update-of-a%C3%A2-systematic-review
#38
REVIEW
Carsten Nieder, Jonas Willmann, Nicolaus H Andratschke
BACKGROUND: Reirradiation is a potentially useful option for many patients with recurrent cancer, aiming at cure or symptom palliation, depending on disease/recurrence type and stage. The purpose of this follow-up study to a previous review from 2016 was to summarize all recently published randomized trials. Points of interest again included identifcation of methodological strengths and weaknesses, practice-changing results, and open questions. MATERIAL AND METHODS: Systematic review of trials published between 2015 and February 2023...
July 27, 2023: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://read.qxmd.com/read/37431225/emergent-radiotherapy-for-brain-and-leptomeningeal-metastases-a-narrative-review
#39
JOURNAL ARTICLE
Andrew B Barbour, Peter Zaki, Tresa M McGranahan, Vyshak Venur, Balamurugan Vellayappan, Joshua Palmer, Lia M Halasz, Jonathan T Yang, Molly Blau, Yolanda D Tseng, Samuel T Chao, John H Suh, Matthew Foote, Kristin J Redmond, Stephanie E Combs, Eric L Chang, Arjun Sahgal, Simon S Lo
BACKGROUND AND OBJECTIVE: As novel systemic therapies allow patients to live longer with cancer, the risk of developing central nervous system (CNS) metastases increases and providers will more frequently encounter emergent presentation of brain metastases (BM) and leptomeningeal metastases (LM). Management of these metastases requires appropriate work-up and well-coordinated multidisciplinary care. We set out to perform a review of emergent radiotherapy (RT) for CNS metastases, specifically focusing on BM and LM...
June 27, 2023: Annals of Palliative Medicine
https://read.qxmd.com/read/37398764/rectum-to-medulla-oblongata-colorectal-cancer-metastasizing-to-the-brainstem
#40
Rachaita Lakra, Philip Bouchette, Milin Rana, Shreedhar Kulkarni
Metastasis with colorectal cancer (CRC) is commonly seen in the liver, lungs and peritoneal cavity. Brainstem involvement with CRC is not studied with no prior reported cases. We report a case of CRC, admitted for apneic spells and dry cough and later found to have metastasis to the left anterolateral medulla oblongata. A 28-year-old male, with a past medical history of asthma, and colorectal adenocarcinoma metastatic to the brain, presented to the emergency department with complaints of a dry cough, altered mental status and shortness of breath...
May 2023: Curēus
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