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"Katz, J"

S P Mehta, A Sankar, V Venkataramanan, L S Lohmander, J N Katz, G A Hawker, L Gossec, E M Roos, J-F Maillefert, M Kloppenburg, M Dougados, A M Davis
OBJECTIVE: To evaluate the internal consistency and construct validity of the Physical Function short-forms for the Hip and Knee Injury Osteoarthritis Outcome Scores (HOOS-PS/KOOS-PS) and the Intermittent and Constant Osteoarthritis Pain (ICOAP) in a nine country study of patients consulting for total hip or knee replacement (THR or TKR). METHODS: Patients completed HOOS-PS or KOOS-PS, ICOAP and Western Ontario and McMaster Universities' Osteoarthritis Index (WOMAC) pain and physical function subscales at their consultation visit...
August 4, 2016: Osteoarthritis and Cartilage
Ccg Chen, D Barry, S K Khatry, E M Klasen, M Singh, S C LeClerq, J Katz, J M Tielsch, L C Mullany
OBJECTIVE: To validate a symptom-based fistula screening questionnaire and estimate obstetric fistula (OF) prevalence in rural Nepal. DESIGN: Cross-sectional and nested case-control study. SETTING: Sarlahi District, Nepal. POPULATION: Parous, reproductive age women. METHODS: The questionnaire assessed symptoms of vesicovaginal and rectovaginal fistula (VVF and RVF, respectively), stress and urge urinary incontinence (SUI and UUI, respectively), fecal incontinence (FI), and included interviewer observations on the smell and presence of urine and/or stool...
July 27, 2016: BJOG: An International Journal of Obstetrics and Gynaecology
L Gedmintas, E A Wright, Y Dong, E Lehmann, J N Katz, D H Solomon, E Losina
: This study aims to determine what factors are associated with increased risk of fracture among patients with HIV, in particular whether an important medication used to treat HIV, tenofovir, is associated with fracture. Our study found that while co-infection with hepatitis C and markers of HIV severity were associated with fracture, tenofovir was not. INTRODUCTION: Growing evidence suggests that tenofovir disoproxil fumarate decreases bone density among patients with HIV, but there are conflicting reports as to whether this decrease in bone density translates to higher fracture risk...
July 15, 2016: Osteoporosis International
C Neuville, V Tassin, D Pesme, M-C Monteil, P-E Masson-Laborde, C Baccou, P Fremerye, F Philippe, P Seytor, D Teychenné, W Seka, J Katz, R Bahr, S Depierreux
The indirect-drive scheme to inertial confinement fusion uses a large number of laser beams arranged in a symmetric angular distribution. Collective laser plasma instabilities can therefore develop that couple all the incident laser waves located in a cone to the daughter wave growing along the cone symmetry axis [D. F. DuBois et al., Phys. Fluids B 4, 241 (1992)]. With complementary diagnostics of Thomson scattering and of the scattered light, we demonstrate the occurrence of collective stimulated Brillouin sidescattering driving collective acoustic waves in indirect-drive experiments...
June 10, 2016: Physical Review Letters
J Sylvan Katz
Innovation systems are sometimes referred to as complex systems, something that is intuitively understood but poorly defined. A complex system dynamically evolves in non-linear ways giving it unique properties that distinguish it from other systems. In particular, a common signature of complex systems is scale-invariant emergent properties. A scale-invariant property can be identified because it is solely described by a power law function, f(x) = kxα, where the exponent, α, is a measure of scale-invariance...
2016: PloS One
W R Donaldson, J Katz, R Huff, E M Hill, J H Kelly, J Kwiatkowski, R B Brannon, R Boni
A timing system is demonstrated for the OMEGA Laser System that guarantees all 60 beams will arrive on target simultaneously with a root mean square variability of 4 ps. The system relies on placing a scattering sphere at the target position to couple the ultraviolet light from each beam into a single photodetector.
May 2016: Review of Scientific Instruments
C Stoeckl, R Boni, F Ehrne, C J Forrest, V Yu Glebov, J Katz, D J Lonobile, J Magoon, S P Regan, M J Shoup, A Sorce, C Sorce, T C Sangster, D Weiner
A next-generation neutron temporal diagnostic (NTD) capable of recording high-quality data for the highest anticipated yield cryogenic deuterium-tritium (DT) implosion experiments was recently installed at the Omega Laser Facility. A high-quality measurement of the neutron production width is required to determine the hot-spot pressure achieved in inertial confinement fusion experiments-a key metric in assessing the quality of these implosions. The design of this NTD is based on a fast-rise-time plastic scintillator, which converts the neutron kinetic energy to 350- to 450-nm-wavelength light...
May 2016: Review of Scientific Instruments
R K Follett, J A Delettrez, D H Edgell, V N Goncharov, R J Henchen, J Katz, D T Michel, J F Myatt, J Shaw, A A Solodov, C Stoeckl, B Yaakobi, D H Froula
Multilayer direct-drive inertial-confinement-fusion targets are shown to significantly reduce two-plasmon decay (TPD) driven hot-electron production while maintaining high hydrodynamic efficiency. Implosion experiments on the OMEGA laser used targets with silicon layered between an inner beryllium and outer silicon-doped plastic ablator. A factor-of-5 reduction in hot-electron generation (>50  keV) was observed in the multilayer targets relative to pure CH targets. Three-dimensional simulations of the TPD-driven hot-electron production using a laser-plasma interaction code (lpse) that includes nonlinear and kinetic effects show good agreement with the measurements...
April 15, 2016: Physical Review Letters
J Katz, M-A d'Albis, J Boisgontier, C Poupon, J-F Mangin, P Guevara, D Duclap, N Hamdani, J Petit, D Monnet, P Le Corvoisier, M Leboyer, R Delorme, J Houenou
OBJECTIVE: High-functioning autism (HFA) and schizophrenia (SZ) are two of the main neurodevelopmental disorders, sharing several clinical dimensions and risk factors. Their exact relationship is poorly understood, and few studies have directly compared both disorders. Our aim was thus to directly compare neuroanatomy of HFA and SZ using a multimodal MRI design. METHODS: We scanned 79 male adult subjects with 3T MRI (23 with HFA, 24 with SZ and 32 healthy controls, with similar non-verbal IQ)...
July 2016: Acta Psychiatrica Scandinavica
R R Edwards, A J Dolman, E Michna, J N Katz, S S Nedeljkovic, D Janfaza, Z Isaac, M O Martel, R N Jamison, A D Wasan
OBJECTIVE: Opioids are frequently prescribed for chronic low back pain (CLBP), but there are broad individual differences in the benefits and risks of opioid therapy, including the development opioid-induced hyperalgesia. This study examined quantitative sensory testing (QST) data among a group of CLBP patients undergoing sustained oral opioid treatment. We investigated whether individual differences in psychological characteristics were related to opioid-induced changes in pain perception and pain modulation...
March 1, 2016: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
N Amram, G Hacohen-Kleiman, S Sragovich, A Malishkevich, J Katz, O Touloumi, R Lagoudaki, N C Grigoriadis, E Giladi, A Yeheskel, M Pasmanik-Chor, Y Jouroukhin, I Gozes
Activity-dependent neuroprotective protein (ADNP), essential for brain formation, is a frequent autism spectrum disorder (ASD)-mutated gene. ADNP associates with microtubule end-binding proteins (EBs) through its SxIP motif, to regulate dendritic spine formation and brain plasticity. Here, we reveal SKIP, a novel four-amino-acid peptide representing an EB-binding site, as a replacement therapy in an outbred Adnp-deficient mouse model. We discovered, for the first time, axonal transport deficits in Adnp(+/-) mice (measured by manganese-enhanced magnetic resonance imaging), with significant male-female differences...
October 2016: Molecular Psychiatry
H Clarke, G M Pagé, C J L McCartney, A Huang, P Stratford, J Andrion, D Kennedy, I T Awad, J Gollish, J Kay, J Katz
BACKGROUND: This study examined whether a perioperative regimen of pregabalin added to celecoxib improved pain scores and functional outcomes postdischarge up to 3 months after total hip arthroplasty (primary outcome) and acute postoperative pain and adverse effects (secondary outcomes). METHODS: One hundred and eighty-four patients were enrolled in a randomized, double-blind, placebo-controlled study. Two hours before receiving a spinal anaesthetic and undergoing surgery, patients received celecoxib 400 mg p...
December 2015: British Journal of Anaesthesia
S Narayanan, A Wilson, J Katz, S Fernando
No abstract text is available yet for this article.
November 2015: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
F Eckstein, J E Collins, M C Nevitt, J A Lynch, V B Kraus, J N Katz, E Losina, W Wirth, A Guermazi, F W Roemer, D J Hunter
OBJECTIVE: To investigate the association of cartilage thickness change over 24 months, as determined by magnetic resonance imaging (MRI), with knee osteoarthritis (OA) progression at 24-48 months. METHODS: This nested case-control study included 600 knees with a baseline Kellgren/Lawrence (K/L) grade of 1-3 from 600 Osteoarthritis Initiative (OAI) participants. Case knees (n = 194) had both medial tibiofemoral radiographic joint space loss (≥0.7 mm) and a persistent increase in the Western Ontario and McMaster Universities Osteoarthritis Index pain score (≥9 on a 0-100 scale) 24-48 months from baseline...
December 2015: Arthritis & Rheumatology
P K Drain, J M Kleene, S M Coleman, E Losina, J N Katz, J Giddy, D Ross, K A Freedberg, I V Bassett
OBJECTIVES: The World Health Organization (WHO) recommends screening HIV-infected people for cryptococcal antigens to identify cryptococcosis, a major cause of AIDS-related deaths. As the burden of cryptococcosis is unknown in South Africa's KwaZulu-Natal province, we assessed the cryptococcal antigenuria prevalence among newly diagnosed HIV-infected adults there. METHODS: We conducted a cross-sectional study of newly diagnosed HIV-infected adults who received voluntary HIV testing in an out-patient clinic...
November 2015: HIV Medicine
J N Katz, E Losina, L S Lohmander
To highlight methodological challenges in the design and conduct of randomized trials of surgical interventions and to propose strategies for addressing these challenges. This paper focuses on three broad areas: enrollment; intervention; and assessment including implications for analysis. For each challenge raised in the paper, we propose potential solutions. Enrollment poses challenges in maintaining investigator equipoise, managing conflict of interest and anticipating that patient preferences for specific treatments may reduce enrollment...
May 2015: Osteoarthritis and Cartilage
E Losina, J Ranstam, J E Collins, T J Schnitzer, J N Katz
To highlight methodologic challenges pertinent to design, analysis, and reporting of results of randomized clinical trials in OA and offer practical suggestions to overcome these challenges. The topics covered in this paper include subject selection, randomization, approaches to handling missing data, subgroup analysis, sample size, and issues related to changing design mid-way through the study. Special attention is given to standardizing the reporting of results and economic analyses. Key findings include the importance of blinding and concealment, the distinction between superiority and non-inferiority trials, the need to minimize missing data, and appropriate analysis and interpretation of subgroup effects...
May 2015: Osteoarthritis and Cartilage
R K Follett, D H Edgell, R J Henchen, S X Hu, J Katz, D T Michel, J F Myatt, J Shaw, D H Froula
A 263-nm Thomson-scattering beam was used to directly probe two-plasmon-decay (TPD) excited electron plasma waves (EPWs) driven by between two and five 351-nm beams on the OMEGA Laser System. The amplitude of these waves was nearly independent of the number of drive beams at constant overlapped intensity, showing that the observed EPWs are common to the multiple beams. In an experimental configuration where the Thomson-scattering diagnostic was not wave matched to the common TPD EPWs, a broad spectrum of TPD-driven EPWs was observed, indicative of nonlinear effects associated with TPD saturation...
March 2015: Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics
M G Pagé, E M Romero Escobar, J Katz, H Clarke
No abstract text is available yet for this article.
June 2015: Pain
A L Northcutt, M R Hutchinson, X Wang, M V Baratta, T Hiranita, T A Cochran, M B Pomrenze, E L Galer, T A Kopajtic, C M Li, J Amat, G Larson, D C Cooper, Y Huang, C E O'Neill, H Yin, N R Zahniser, J L Katz, K C Rice, S F Maier, R K Bachtell, L R Watkins
The initial reinforcing properties of drugs of abuse, such as cocaine, are largely attributed to their ability to activate the mesolimbic dopamine system. Resulting increases in extracellular dopamine in the nucleus accumbens (NAc) are traditionally thought to result from cocaine's ability to block dopamine transporters (DATs). Here we demonstrate that cocaine also interacts with the immunosurveillance receptor complex, Toll-like receptor 4 (TLR4), on microglial cells to initiate central innate immune signaling...
December 2015: Molecular Psychiatry
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