Sudarsan Krishnasamy, Bobbity Deepthi, Nivedita Kamath, Arpana Iyengar, Christy Cathreen Thomas, Susan Uthup, Anshuman Saha, Georgie Mathew, Indira Agarwal, Karalanglin Tiewsoh, Nowneet Kumar Bhat, Kausik Mandal, Sriram Krishnamurthy
BACKGROUND: Three types of primary hyperoxaluria (PH) are recognized. However, data on PH type 2 (PH2), caused by defects in the GRHPR gene, are limited. METHODS: We reviewed the medical records of patients < 18 years of age with genetically-proven PH2 from seven centres across India to identify the age of onset, patterns of clinical presentation, short-term outcomes and genetic profile, and to determine if genotype-phenotype correlation exists. RESULTS: We report 20 patients (all with nephrolithiasis or nephrocalcinosis) diagnosed to have PH2 at a median (IQR) age of 21...
November 2, 2023: Pediatric Nephrology