keyword
MENU ▼
Read by QxMD icon Read
search

Macaque brain

keyword
https://www.readbyqxmd.com/read/28710037/rna-editing-independently-occurs-at-three-mir-376a-1-sites-and-may-compromise-the-stability-of-the-microrna-hairpin
#1
Alicia Gallego, Diego A Hartasánchez, Marina Brasó-Vives, Eva Garcia-Ramallo, Maria Lopez-Valenzuela, Neus Baena, Miriam Guitart, Hugo Fernández-Bellon, Ivanela Kondova, Ronald Bontrop, Yukio Kawahara, Yolanda Espinosa-Parrilla
RNA editing is being recognized as an important post-transcriptional mechanism that may have crucial roles in introducing genetic variation and phenotypic diversity. Despite microRNA editing recurrence, defining its biological relevance is still under extended debate. To better understand microRNA editing function and regulation we performed an exhaustive characterization of the A-to-I site-specific patterns in mir-376a-1, a mammalian microRNA which RNA editing is involved in the regulation of development and in disease...
July 11, 2017: Gene
https://www.readbyqxmd.com/read/28707157/parcellation-of-macaque-cortex-with-anatomical-connectivity-profiles
#2
Jiaojian Wang, Zhentao Zuo, Sangma Xie, Yifan Miao, Yuanye Ma, Xudong Zhao, Tianzi Jiang
The macaque model has been widely used to investigate the brain mechanisms of specific cognitive functions and psychiatric disorders. However, a detailed functional architecture map of the macaque cortex in vivo is still lacking. Here, we aimed to construct a new macaque cortex atlas based on its anatomical connectivity profiles using in vivo diffusion MRI. First, we defined the macaque cortical seed areas using the NeuroMaps atlas. Then, we applied the anatomical connectivity patterns-based parcellation approach to parcellate the macaque cortex into 80 subareas in each hemisphere, which were approximately symmetric between the two hemispheres...
July 13, 2017: Brain Topography
https://www.readbyqxmd.com/read/28695214/response-to-lieberman-on-monkey-vocal-tracts-are-speech-ready
#3
W Tecumseh Fitch, Bart de Boer, Neil Mathur, Asif A Ghazanfar
Macaques do have a speech-ready vocal tract, but lack a speech-ready brain to control it.
July 2017: Science Advances
https://www.readbyqxmd.com/read/28693885/post-exposure-treatment-with-the-oxime-rs194b-rapidly-reverses-early-and-advanced-symptoms-in-macaques-exposed-to-sarin-vapor
#4
Yvonne J Rosenberg, Lingjun Mao, Xiaoming Jiang, Jonathan Lees, Limin Zhang, Zoran Radic, Palmer Taylor
Organophosphate (OP) nerve agents and pesticides trigger a common mechanism of neurotoxicity resulting from critical targeting and inhibition of acetylcholinesterases (AChE) in central and peripheral synapses in the cholinergic nervous system. Therapeutic countermeasures have thus focused on either administering an oxime post-exposure, that can rapidly reactivate OP-inhibited AChE, or by preventing OP poisoning through administering pre-exposure treatments that scavenge OPs before they inhibit their physiological AChE targets...
July 8, 2017: Chemico-biological Interactions
https://www.readbyqxmd.com/read/28687705/annotation-and-cluster-analysis-of-spatiotemporal-and-sex-related-lncrna-expression-in-rhesus-macaque-brain
#5
Siling Liu, Zhengbo Wang, Dong Chen, Bowen Zhang, Renrong Tian, Jing Wu, Ying Zhang, Kaiyu Xu, Liumeng Yang, Chao Cheng, Jian Ma, Longbao Lv, Yongtang Zheng, Xintian Hu, Yi Zhang, Xiangting Wang, Jiali Li
Long noncoding RNA (lncRNA)-mediated epigenetic regulation plays important roles in wide range of biological processes and diseases. Here, we applied comprehensive analyses of RNA-seq and CAGE-seq (cap analysis of gene expression and sequencing) to characterize the dynamic changes in lncRNA expression in rhesus macaque brain in four age groups from postnatal to aged periods. We identified 18 anatomically diverse lncRNA modules and 14 mRNA modules representing spatial, age and sex specificities. Spatiotemporal- and sex-biased changes in lncRNA expression are in general higher than that observed in mRNA expression...
July 7, 2017: Genome Research
https://www.readbyqxmd.com/read/28687313/two-different-mirror-neuron-networks-the-sensorimotor-hand-and-limbic-face-pathways
#6
REVIEW
P F Ferrari, M Gerbella, G Coudé, S Rozzi
The vast majority of functional studies investigating mirror neurons (MNs) explored their properties in relation to hand actions, and very few investigated how MNs respond to mouth actions or communicative gestures. Since hand and mouth MNs were recorded in two partially overlapping sectors of the ventral precentral cortex of the macaque monkey, there is a general assumption that they share a same neuroanatomical network, with the parietal cortex as a main source of visual information. In the current review, we challenge this perspective and describe the connectivity pattern of mouth MNs sector...
July 4, 2017: Neuroscience
https://www.readbyqxmd.com/read/28671956/a-multiscale-cerebral-neurochemical-connectome-of-the-rat-brain
#7
Hamid R Noori, Judith Schöttler, Maria Ercsey-Ravasz, Alejandro Cosa-Linan, Melinda Varga, Zoltan Toroczkai, Rainer Spanagel
Understanding the rat neurochemical connectome is fundamental for exploring neuronal information processing. By using advanced data mining, supervised machine learning, and network analysis, this study integrates over 5 decades of neuroanatomical investigations into a multiscale, multilayer neurochemical connectome of the rat brain. This neurochemical connectivity database (ChemNetDB) is supported by comprehensive systematically-determined receptor distribution maps. The rat connectome has an onion-type structural organization and shares a number of structural features with mesoscale connectomes of mouse and macaque...
July 2017: PLoS Biology
https://www.readbyqxmd.com/read/28668502/bdnf-as-a-possible-modulator-of-eeg-oscillatory-response-at-the-parietal-cortex-during-visuo-tactile-integration-processes-using-a-rubber-hand
#8
Ryosuke Hiramoto, Noriaki Kanayama, Takashi Nakao, Tomoya Matsumoto, Hirona Konishi, Satoru Sakurai, Go Okada, Yasumasa Okamoto, Shigeto Yamawaki
Multisensory integration of visuo-tactile information presented on the body or a dummy body has a strong impact on body image. Previous research shows that alteration of body image induced by visuo-tactile integration is closely related to the activation of the parietal cortex, a sensory association area. The expression of brain-derived neurotrophic factor (BDNF) in the parietal area of macaque monkeys is thought to modulate the activation of the parietal cortex and alter the extension of body image during tool-use learning...
June 28, 2017: Neuroscience Research
https://www.readbyqxmd.com/read/28659785/the-impact-of-aging-on-brain-pituitary-adenylate-cyclase-activating-polypeptide-pathology-and-cognition-in-mice-and-rhesus-macaques
#9
Pengcheng Han, Megan Nielsen, Melissa Song, Junxiang Yin, Michele R Permenter, Julie A Vogt, James R Engle, Brittany N Dugger, Thomas G Beach, Carol A Barnes, Jiong Shi
Pituitary adenylate cyclase activating polypeptide (PACAP) is associated with Alzheimer's disease (AD), but its age-related effects are unknown. We chose the rhesus macaque due to its closeness to human anatomy and physiology. We examined four variables: aging, cognitive performance, amyloid plaques and PACAP. Delayed nonmatching-to-sample recognition memory scores declined with age and correlated with PACAP levels in the striatum, parietal and temporal lobes. Because amyloid plaques were the only AD pathology in the old rhesus macaque, we further studied human amyloid precursor protein (hAPP) transgenic mice...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/28655928/brain-activity-changes-in-a-macaque-model-of-oxaliplatin-induced-neuropathic-cold-hypersensitivity
#10
Kazuaki Nagasaka, Kazunori Yamanaka, Shinya Ogawa, Hiroyuki Takamatsu, Noriyuki Higo
The antineoplastic agent oxaliplatin induces a painful peripheral neuropathy characterized by an acute cold hypersensitivity. There is a lack of effective treatments to manage oxaliplatin-induced cold hypersensitivity which is due, in part, to a lack of understanding of the pathophysiology of oxaliplatin-induced cold hypersensitivity. Thus, brain activity in oxaliplatin-treated macaques was examined using functional magnetic resonance imaging (fMRI). Oxaliplatin treatment reduced tail withdrawal latency to a cold (10 °C) stimulus, indicating cold hypersensitivity and increased activation in the secondary somatosensory cortex (SII) and the anterior insular cortex (Ins) was observed...
June 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28647390/neural-synergies-for-controlling-reach-and-grasp-movement-in-macaques
#11
Yaoyao Hao, Shaomin Zhang, Qiaosheng Zhang, Guanglin Li, Weidong Chen, Xiaoxiang Zheng
It has been suggested that the brain adopts a simplified strategy to coordinate a large number of degrees of freedom in motor control. Synergies have been proposed as a strategy to produce movements by recruitment of a small number of fixed modular patterns. However, there is no direct support for a synergistic organization of the brain itself. In this study, we recorded neural activities from the dorsal premotor cortex (PMd) of monkeys trained to reach and grasp differently shaped objects (grasping task) or the same object in different positions (reaching task)...
June 22, 2017: Neuroscience
https://www.readbyqxmd.com/read/28641988/wavy-multistratified-amacrine-cells-in-the-monkey-retina-contain-immunoreactive-secretoneurin
#12
Andrea S Bordt, Ye Long, Nobuo Kouyama, Elizabeth S Yamada, Jens Hannibal, David W Marshak
The goals of this study were to describe the morphology, neurotransmitter content and synaptic connections of neurons in primate retinas that contain the neuropeptide secretoneurin. Amacrine cells were labeled with antibodies to secretoneurin in macaque and baboon retinas. Their processes formed three distinct plexuses in the inner plexiform layer: one in the outermost stratum, one in the center and one in the innermost stratum. In light microscopic double immunolabeling experiments, GABA was colocalized with secretoneurin in these cells, but glycine transporter 1 and Substance P were not...
June 19, 2017: Peptides
https://www.readbyqxmd.com/read/28634624/population-averaged-macaque-brain-atlas-with-high-resolution-ex-vivo-dti-integrated-into-in-vivo-space
#13
Lei Feng, Tina Jeon, Qiaowen Yu, Minhui Ouyang, Qinmu Peng, Virendra Mishra, Mihovil Pletikos, Nenad Sestan, Michael I Miller, Susumu Mori, Steven Hsiao, Shuwei Liu, Hao Huang
Animal models of the rhesus macaque (Macaca mulatta), the most widely used nonhuman primate, have been irreplaceable in neurobiological studies. However, a population-averaged macaque brain diffusion tensor imaging (DTI) atlas, including comprehensive gray and white matter labeling as well as bony and facial landmarks guiding invasive experimental procedures, is not available. The macaque white matter tract pathways and microstructures have been rarely recorded. Here, we established a population-averaged macaque brain atlas with high-resolution ex vivo DTI integrated into in vivo space incorporating bony and facial landmarks, and delineated microstructures and three-dimensional pathways of major white matter tracts in vivo MRI/DTI and ex vivo (postmortem) DTI of ten rhesus macaque brains were acquired...
June 20, 2017: Brain Structure & Function
https://www.readbyqxmd.com/read/28628526/determinants-of-hiv-1-cd4-independent-brain-adaptation
#14
Madina Shakirzyanova, Xiang-Peng Kong, Cecilia Cheng-Mayer
BACKGROUND: HIV-1 is known to adapt to the local environment in its usage of receptors and it can become CD4 independent in the brain where the receptor is scarce. This adaptation is through amino acid variations, but the patterns of such variation are not yet well understood. Given that infection of long-lived CD4-low and CD4-negative cells in anatomic compartments such as the brain expand cell tropism in vivo and may serve as potential viral reservoirs that pose challenge for HIV eradication, understanding the evolution to CD4-independence and envelope conformation associated with infection in the absence of CD4 will not only broaden our insights into HIV pathogenesis, but may guide functional cure strategies as well...
June 15, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28625485/motor-cortical-visuomotor-feedback-activity-is-initially-isolated-from-downstream-targets-in-output-null-neural-state-space-dimensions
#15
Sergey D Stavisky, Jonathan C Kao, Stephen I Ryu, Krishna V Shenoy
Neural circuits must transform new inputs into outputs without prematurely affecting downstream circuits while still maintaining other ongoing communication with these targets. We investigated how this isolation is achieved in the motor cortex when macaques received visual feedback signaling a movement perturbation. To overcome limitations in estimating the mapping from cortex to arm movements, we also conducted brain-machine interface (BMI) experiments where we could definitively identify neural firing patterns as output-null or output-potent...
July 5, 2017: Neuron
https://www.readbyqxmd.com/read/28607170/oxytocin-and-serotonin-brain-mechanisms-in-the-non-human-primate
#16
Arthur Lefevre, Nathalie Richard, Mina Jazayeri, Pierre-Aurélien Beuriat, Sylvain Fieux, Luc Zimmer, Jean-René Duhamel, Angela Sirigu
Oxytocin is increasingly studied for its therapeutic potential in psychiatric disorders which are associated with the deregulation of several neurotransmission systems. Studies in rodents demonstrated that the interaction between oxytocin (OT) and serotonin (5-HT) is critical for several aspects of social behavior. Using PET-scan in humans we have recently found that 5-HT 1A receptor (5-HT1AR) function is modified after intra-nasal oxytocin intake. However, the underlying mechanism between OT and 5-HT remains unclear...
June 12, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28575666/the-code-for-facial-identity-in-the-primate-brain
#17
Le Chang, Doris Y Tsao
Primates recognize complex objects such as faces with remarkable speed and reliability. Here, we reveal the brain's code for facial identity. Experiments in macaques demonstrate an extraordinarily simple transformation between faces and responses of cells in face patches. By formatting faces as points in a high-dimensional linear space, we discovered that each face cell's firing rate is proportional to the projection of an incoming face stimulus onto a single axis in this space, allowing a face cell ensemble to encode the location of any face in the space...
June 1, 2017: Cell
https://www.readbyqxmd.com/read/28561903/arcuate-nucleus-neuropeptide-coexpression-and-connections-to-gonadotrophin-releasing-hormone-neurones-in-the-female-rhesus-macaque
#18
C True, D Takahashi, M Kirigiti, S R Lindsley, C Moctezuma, A Arik, M S Smith, P Kievit, K L Grove
The underlying hypothalamic neurocircuitry by which metabolism and feeding regulates reproductive function has been well-studied in the rodent; however, recent data have demonstrated significant neuroanatomical differences in the human brain. The present study had three objectives, centred on arcuate nucleus neuropeptides regulating feeding and reproduction: (i) to characterise coexpression patterns in the female nonhuman primate; (ii) to establish whether these neuronal populations make potential contacts with gonadotophin-releasing hormone (GnRH) neurones; and (iii) to determine whether these contacts differ between the low and high GnRH-releasing states of pre-puberty and adulthood, respectively...
June 2017: Journal of Neuroendocrinology
https://www.readbyqxmd.com/read/28545042/hierarchical-ordering-with-partial-pairwise-hierarchical-relationships-on-the-macaque-brain-data-sets
#19
Woosang Lim, Jungsoo Lee, Yongsub Lim, Doo-Hwan Bae, Haesun Park, Dae-Shik Kim, Kyomin Jung
Hierarchical organizations of information processing in the brain networks have been known to exist and widely studied. To find proper hierarchical structures in the macaque brain, the traditional methods need the entire pairwise hierarchical relationships between cortical areas. In this paper, we present a new method that discovers hierarchical structures of macaque brain networks by using partial information of pairwise hierarchical relationships. Our method uses a graph-based manifold learning to exploit inherent relationship, and computes pseudo distances of hierarchical levels for every pair of cortical areas...
2017: PloS One
https://www.readbyqxmd.com/read/28532347/strabismus-and-the-oculomotor-system-insights-from-macaque-models
#20
Vallabh E Das
Disrupting binocular vision in infancy leads to strabismus and oftentimes to a variety of associated visual sensory deficits and oculomotor abnormalities. Investigation of this disorder has been aided by the development of various animal models, each of which has advantages and disadvantages. In comparison to studies of binocular visual responses in cortical structures, investigations of neural oculomotor structures that mediate the misalignment and abnormalities of eye movements have been more recent, and these studies have shown that different brain areas are intimately involved in driving several aspects of the strabismic condition, including horizontal misalignment, dissociated deviations, A and V patterns of strabismus, disconjugate eye movements, nystagmus, and fixation switch...
October 14, 2016: Annual Review of Vision Science
keyword
keyword
115765
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"