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https://www.readbyqxmd.com/read/28498065/effect-of-interval-and-continuous-aerobic-training-on-basal-serum-and-plasma-bdnf-values-in-seniors-a-systematic-review-of-intervention-studies
#1
Lievyn Enette, Thomas Vogel, Jean Luc Fanon, Pierre Olivier Lang
The purpose of this systematic review was to provide a comprehensive analysis of the available clinical trials analyzing, in seniors, the effect of aerobic interval training (IAT) and continuous aerobic training (CAT) on peripheral Brain-derived neurotropic factor (BDNF) concentration. We identified 14 randomized or not-randomized intervention studies published up to January 2017 through a computer-assisted search (PUBMED, Pedro, and Science direct data bases). The 5 trials considering IAT and the 9 CAT totalized 988 individuals (age range: 58...
May 12, 2017: Rejuvenation Research
https://www.readbyqxmd.com/read/28493674/surface-enhanced-spatially-offset-raman-spectroscopy-detection-of-neurochemicals-through-the-skull
#2
Amber S Moody, Peymon C Baghernejad, Kelsey R Webb, Bhavya Sharma
The ability to noninvasively detect neurotransmitters through the skull would aid in understanding brain function and the development of neurological diseases. Surface enhanced spatially offset Raman spectroscopy (SESORS) is a powerful technique that combines the sensitivity of surface-enhanced Raman spectroscopy (SERS) with the ability of spatially offset Raman spectroscopy (SORS) to probe subsurface layers. Here we present SERS measurements of neurotransmitters (melatonin, serotonin, and epinephrine) at various concentrations followed by the SESORS measurements of the neurotransmitters to a concentration as low as 100 μM in a brain tissue mimic through a cat skull...
May 16, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28493068/cathepsin-s-increases-tau-oligomer-formation-through-limited-cleavage-but-only-il-6-not-cathespin-s-serum-levels-correlate-with-disease-severity-in-the-neurodegenerative-tauopathy-progressive-supranuclear-palsy
#3
Georg Nübling, M Schuberth, K Feldmer, A Giese, L M Holdt, D Teupser, S Lorenzl
Limited cleavage promotes the aggregation propensity of protein tau in neurodegenerative tauopathies. Cathepsin S (CatS) is overexpressed in brains of patients suffering from tauopathies such as Alzheimer's disease (AD). Furthermore, CatS serum levels correlate with survival in the elderly. The current study investigates whether limited cleavage by CatS promotes tau aggregation, and whether CatS serum levels may correlate with disease severity in tauopathies. Oligomer formation of fluorescently labeled protein tau was monitored by single particle fluorescence spectroscopy after coincubation with CatS...
May 10, 2017: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
https://www.readbyqxmd.com/read/28489966/acrylamide-induced-disturbance-of-the-redox-balance-in-the-chick-embryonic-brain
#4
Marta Batoryna, Marcin Lis, Grzegorz Formicki
This study was undertaken to determine the redox balance in the developing brain after exposure to acrylamide (ACR), a potent neurotoxin. The studies were performed using an in ovo chick embryo model. The antioxidant enzymes SOD, GPx, CAT, and reduced glutathione (GSH) were used as indicators of the redox balance. Eggs were injected with ACR doses of 40 mg kg(-1) egg mass (2.4 mg egg(-1)) on embryonic day 17 (E17). The activity of the antioxidant enzymes and the concentration of GSH were measured at E17, E18, and E19 in the medulla oblongata, cerebrum, cerebellum, and optic lobe...
May 10, 2017: Journal of Environmental Science and Health. Part. B, Pesticides, Food Contaminants, and Agricultural Wastes
https://www.readbyqxmd.com/read/28482759/caffeine-prevents-high-intensity-exercise-induced-increase-in-enzymatic-antioxidant-and-na-k-atpase-activities-and-reduction-of-anxiolytic-like-behaviour-in-rats
#5
Juliano M Vieira, Fabiano B Carvalho, Jessié M Gutierres, Mayara S P Soares, Pathise S Oliveira, Maribel A Rubin, Vera M Morsch, Maria Rosa Schetinger, Roselia M Spanevello
OBJECTIVE: Here we investigated the impact of chronic high-intensity interval training (HIIT) and caffeine consumption on the activities of Na(+)-K(+)-ATPase and enzymes of the antioxidant system, as well as anxiolytic-like behaviour in the rat brain. METHODS: Animals were divided into groups: control, caffeine (4 mg/kg), caffeine (8 mg/kg), HIIT, HIIT plus caffeine (4 mg/kg) and HIIT plus caffeine (8 mg/kg). Rats were trained three times per week for 6 weeks, and caffeine was administered 30 minutes before training...
May 8, 2017: Redox Report: Communications in Free Radical Research
https://www.readbyqxmd.com/read/28477202/acute-and-chronic-treatment-with-quetiapine-induces-antidepressant-like-behavior-and-exerts-antioxidant-effects-in-the-rat-brain
#6
Zuleide M Ignácio, Gislaine Z Réus, Helena M Abelaira, Airam B de Moura, Thays G de Souza, Danyela Matos, Mariana P Goldim, Khiany Mathias, Leandro Garbossa, Fabricia Petronilho, João Quevedo
Many studies note that changes in oxidative balance are involved in the pathogenesis of major depressive disorder (MDD) and in the success of some antidepressants. Quetiapine exerts a therapeutic response and induces changes in physiological mechanisms that appear to underlie MDD. The objective of this study was to evaluate the antidepressant and antioxidant effects of quetiapine (20 mg /kg) in adult animals. Sixty minutes after an acute treatment or the last administration of chronic treatment (14 days) with quetiapine, animals were subjected to the forced swimming test (FST) to evaluate mobility parameters...
May 6, 2017: Metabolic Brain Disease
https://www.readbyqxmd.com/read/28472953/protective-effects-of-carnosol-against-oxidative-stress-induced-brain-damage-by-chronic-stress-in-rats
#7
Saeed Samarghandian, Mohsen Azimi-Nezhad, Abasalt Borji, Mohammad Samini, Tahereh Farkhondeh
BACKGROUND: Oxidative stress through chronic stress destroys the brain function. There are many documents have shown that carnosol may have a therapeutic effect versus free radical induced diseases. The current research focused the protective effect of carnosol against the brain injury induced by the restraint stress. METHODS: The restraint stress induced by keeping animals in restrainers for 21 consecutive days. Thereafter, the rats were injected carnosol or vehicle for 21 consecutive days...
May 4, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28458103/changes-in-the-interictal-and-early-postictal-diffusion-and-perfusion-magnetic-resonance-parameters-in-familial-spontaneous-epileptic-cats
#8
Yuji Hamamoto, Daisuke Hasegawa, Shunta Mizoguchi, Yoshihiko Yu, Masae Wada, Takayuki Kuwabara, Aki Fujiwara-Igarashi, Michio Fujita
OBJECTIVE: The familial spontaneous epileptic cat (FSEC) is thought to be a good genetic model of mesial temporal lobe epilepsy. In the current study, cerebral diffusion and perfusion magnetic resonance imaging (MRI) were used to confirm the functional deficit zone in the FSEC and evaluate the effect of a single seizure on different brain regions. METHODS: Six FSECs and six healthy control cats were used in this study. MRI was performed in the interictal state (resting state for control) and postictal state immediately after the vestibular stimulation-induced generalized epileptic seizure (control cats received the same stimulation as the FSECs)...
April 23, 2017: Epilepsy Research
https://www.readbyqxmd.com/read/28458069/postnatal-development-and-behavior-effects-of-in-utero-exposure-of-rats-to-radiofrequency-waves-emitted-from-conventional-wifi-devices
#9
Haifa Othman, Mohamed Ammari, Kaïs Rtibi, Noura Bensaid, Mohsen Sakly, Hafedh Abdelmelek
The present work investigated the effects of prenatal exposure to radiofrequency waves of conventional WiFi devices on postnatal development and behavior of rat offspring. Ten Wistar albino pregnant rats were randomly assigned to two groups (n=5). The experimental group was exposed to a 2.45GHz WiFi signal for 2h a day throughout gestation period. Control females were subjected to the same conditions as treated group without applying WiFi radiations. After delivery, the offspring was tested for physical and neurodevelopment during its 17 postnatal days (PND), then for anxiety (PND 28) and motricity (PND 40-43), as well as for cerebral oxidative stress response and cholinesterase activity in brain and serum (PND 28 and 43)...
April 22, 2017: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/28457881/vulnerability-of-white-matter-tracts-and-cognition-to-the-sod2-polymorphism-a-preliminary-study-of-antioxidant-defense-genes-in-brain-aging
#10
Lauren E Salminen, Peter R Schofield, Kerrie D Pierce, Steven E Bruce, Michael G Griffin, David F Tate, Ryan P Cabeen, David H Laidlaw, Thomas E Conturo, Jacob D Bolzenius, Robert H Paul
Oxidative stress is a key mechanism of the aging process that can cause damage to brain white matter and cognitive functions. Polymorphisms in the superoxide dismutase 2 (SOD2) and catalase (CAT) genes have been associated with abnormalities in antioxidant enzyme activity in the aging brain, suggesting a risk for enhanced oxidative damage to white matter and cognition among older individuals with these genetic variants. The present study compared differences in white matter microstructure and cognition among 96 older adults with and without genetic risk factors of SOD2 (rs4880) and CAT (rs1001179)...
April 27, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28450539/multisensory-integration-uses-a-real-time-unisensory-multisensory-transform
#11
Ryan L Miller, Barry E Stein, Benjamin A Rowland
The manner in which the brain integrates different sensory inputs to facilitate perception and behavior has been the subject of numerous speculations. By examining multisensory neurons in cat superior colliculus, the present study demonstrated that two operational principles are sufficient to understand how this remarkable result is achieved: (1) unisensory signals are integrated continuously and in real time as soon as they arrive at their common target neuron and (2) the resultant multisensory computation is modified in shape and timing by a delayed, calibrating inhibition...
May 17, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28450153/epidural-focal-brain-cooling-abolishes-neocortical-seizures-in-cats-and-non-human-primates
#12
Takao Inoue, Masami Fujii, Hiroyuki Kida, Toshitaka Yamakawa, Yuichi Maruta, Tatsuji Tokiwa, Yeting He, Sadahiro Nomura, Yuji Owada, Takeshi Yamakawa, Michiyasu Suzuki
Focal brain cooling (FBC) is under investigation in preclinical trials of intractable epilepsy (IE), including status epilepticus (SE). This method has been studied in rodents as a possible treatment for epileptic disorders, but more evidence from large animal studies is required. To provide evidence that FBC is a safe and effective therapy for IE, we investigated if FBC using a titanium cooling plate can reduce or terminate focal neocortical seizures without having a significant impact on brain tissue. Two cats and two macaque monkeys were chronically implanted with an epidural FBC device over the somatosensory and motor cortex...
April 24, 2017: Neuroscience Research
https://www.readbyqxmd.com/read/28445615/status-epilepticus-in-dogs-and-cats-part-1-etiopathogenesis-epidemiology-and-diagnosis
#13
Susan Blades Golubovic, John H Rossmeisl
OBJECTIVE: To review current knowledge of the etiopathogenesis, diagnosis, and consequences of status epilepticus (SE) in veterinary patients. DATA SOURCES: Human and veterinary literature, including clinical and laboratory research and reviews. ETIOPATHOGENESIS: Status epilepticus is a common emergency in dogs and cats, and may be the first manifestation of a seizure disorder. It results from the failure of termination of an isolated seizure...
May 2017: Journal of Veterinary Emergency and Critical Care
https://www.readbyqxmd.com/read/28440655/species-and-tissue-specific-profiles-of-polybrominated-diphenyl-ethers-and-their-hydroxylated-and-methoxylated-derivatives-in-cats-and-dogs
#14
Kei Nomiyama, Kohki Takaguchi, Hazuki Mizukawa, Yasuko Nagano, Tomoko Oshihoi, Susumu Nakatsu, Tatsuya Kunisue, Shinsuke Tanabe
The adverse effects of elevated polybrominated diphenyl ether (PBDE) levels, reported in the blood of domestic dogs and cats, are considered to be of great concern. However, the tissue distribution of PBDEs and their derivatives in these animals is poorly understood. This study determined the concentrations and profiles of PBDEs, hydroxylated PBDEs (OH-PBDEs), methoxylated PBDEs (MeO-PBDEs), and 2,4,6-tribromophenol (2,4,6-tri-BPh) in the blood, livers, bile, and brains of dogs and cats in Japan. Higher tissue concentrations of PBDEs were found in cats, with the dominant congener being BDE209...
May 2, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28438969/intracellular-in-vivo-dynamics-of-thalamocortical-synapses-in-visual-cortex
#15
Madineh Sedigh-Sarvestani, Leif Vigeland, Ivan Fernandez-Lamo, Morgan Taylor, Larry A Palmer, Diego Contreras
Seminal studies of the thalamocortical (TC) circuit in the visual system of the cat have been central to our understanding of sensory encoding. However, TC synaptic properties remain poorly understood. We used paired recordings, in the lateral geniculate nucleus (LGN) and primary visual cortex (V1), to provide the first in vivo characterization of sensory-driven TC potentials in V1. The amplitudes of EPSPs we characterized were smaller than those previously reported in vitro. Consistent with prior findings, connected LGN-V1 pairs were only found when their receptive fields (RFs) overlapped, and the probability of connection increased steeply with degree of RF overlap and response similarity...
April 24, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28435763/toxoplasma-infection-in-an-immunocompetent-host-possible-risk-of-living-with-multiple-cats
#16
Halis Kaan Akturk, David Sotello, Allen Ameri, Ahmed S Abuzaid, Ana Marcella Rivas, Priyanka Vashisht
A 32-year-old man presented with agitation, headache, and confusion. He was immunocompetent and had been living with multiple cats for many years. His vital signs were stable. He was afebrile. Multiple blood tests did not show any serious problem. Brain magnetic resonance imaging (MRI) revealed multiple ring-enhancing white matter lesions. Cerebrospinal fluid analysis did not show any signs of infection. Based on a presumptive diagnosis of multiple sclerosis, high-dose corticosteroid treatment was started. However, this caused worsening of the symptoms and increased the size of the lesions...
March 19, 2017: Curēus
https://www.readbyqxmd.com/read/28433933/functional-foods-in-pet-nutrition-focus-on-dogs-and-cats
#17
REVIEW
Alessandro Di Cerbo, Julio Cesar Morales-Medina, Beniamino Palmieri, Federica Pezzuto, Raffaella Cocco, Gonzalo Flores, Tommaso Iannitti
Functional foods provide health benefits if they are consumed on a regular basis as part of a varied diet. In this review, we discuss the availability and role of functional foods in pet nutrition with a focus on dogs and cats. Indeed, functional foods modify gastrointestinal physiology, promote changes in biochemical parameters, improve brain functions and may reduce or minimize the risk of developing specific pathologies. This evidence derives largely from clinical studies while only limited evidence is available from studies in dogs and cats...
April 7, 2017: Research in Veterinary Science
https://www.readbyqxmd.com/read/28433747/chemical-composition-of-ocimum-sanctum-by-lc-esi-ms-ms-analysis-and-its-protective-effects-against-smoke-induced-lung-and-neuronal-tissue-damage-in-rats
#18
M P Venuprasad, Hemanth Kumar Kandikattu, Sakina Razack, Narayanappa Amruta, Farhath Khanum
Smoke induced oxidative stress is known to cause various cancers and associated health problems including lung cancer. Herbal extracts have been reported as antioxidant supplements which attenuate free radical induced oxidative damage of tissues, among which Ocimum sanctum has been reported as the elixir of life due to its innumerable health benefits. In the present study, we investigated the protective effect of O. sanctum against cracker smoke induced lung and brain tissue damage. The results of the study demonstrate that O...
April 20, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28432986/the-effects-of-thymoquinone-on-hippocampal-cytokine-level-brain-oxidative-stress-status-and-memory-deficits-induced-by-lipopolysaccharide-in-rats
#19
Rahimeh Bargi, Fereshteh Asgharzadeh, Farimah Beheshti, Mahmoud Hosseini, Hamid Reza Sadeghnia, Majid Khazaei
OBJECTIVE: The study objective was to determine the protective effects of thymoquinone (TQ) on brain tissues oxidative stress status, hippocampal cytokine level, and learning and memory deficits induced by lipopolysaccharide (LPS) in rats. METHODS: Animals were randomly divided into the following groups and treated: (1) Control (saline), (2) LPS (1mg/kg i.p.), (3-5) 2, 5 or 10mg/kg TQ extract 30min before LPS injection. The treatment was started since two weeks before the behavioral experiments and continued during the behavioral tests (LPS injected 2h before each behavioral experiment)...
April 19, 2017: Cytokine
https://www.readbyqxmd.com/read/28429406/haplodeficiency-of-cathepsin-d-does-not-affect-cerebral-amyloidosis-and-autophagy-in-app-ps1-transgenic-mice
#20
Shaowu Cheng, Willayat Y Wani, David A Hottman, Angela Jeong, Dongfeng Cao, Kyle J LeBlanc, Paul Saftig, Jianhua Zhang, Ling Li
Autophagy and lysosomal function are important for protein homeostasis and their dysfunction have been associated with Alzheimer's disease (AD). Increased immunoreactivities of an important lysosomal protease, cathepsin D (Cat D), are evident in amyloid plaques and neurons in patients with AD. The current study tests the hypothesis that deleting one allele of the cathepsin D gene (Ctsd) impacts cerebral β-amyloidosis in APPsw/PS1dE9 (APP/PS1) double transgenic mice. Despite a significant 38% decrease of Cat D level in APP/PS1/Ctsd+/- compared to APP/PS1/Ctsd+/+ mice, no changes in steady state levels and deposition of Aβ were found in the brain...
April 21, 2017: Journal of Neurochemistry
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