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https://www.readbyqxmd.com/read/28903091/environmental-relevant-concentrations-of-a-chlorpyrifos-commercial-formulation-affect-two-neotropical-fish-species-cheirodon-interruptus-and-cnesterodon-decemmaculatus
#1
Alejo Fabian Bonifacio, María Laura Ballesteros, Rocío Inés Bonansea, Iohanna Filippi, María Valeria Amé, Andrea Cecilia Hued
The increase of cultivated areas together with the intensive use of pesticides have greatly contributed to impair the quality of aquatic systems along different areas of South America. The main goal of the present study was to assess the effects of a commercial formulation of chlorpyrifos at environmentally relevant concentrations on two native fish species, Cheirodon interruptus and Cnesterodon decemmaculatus. Adult individuals were exposed during 48 h to the following concentrations: 0.084 nl/l (Ci-Cf 1) and 0...
August 30, 2017: Chemosphere
https://www.readbyqxmd.com/read/28900508/direct-macromolecular-drug-delivery-to-cerebral-ischemia-area-using-neutrophil-mediated-nanoparticles
#2
Chun Zhang, Cheng-Li Ling, Liang Pang, Qi Wang, Jing-Xin Liu, Bing-Shan Wang, Jian-Ming Liang, Yi-Zhen Guo, Jing Qin, Jian-Xin Wang
Delivery of macromolecular drugs to the brain is impeded by the blood brain barrier. The recruitment of leukocytes to lesions in the brain, a typical feature of neuroinflammation response which occurs in cerebral ischemia, offers a unique opportunity to deliver drugs to inflammation sites in the brain. In the present study, cross-linked dendrigraft poly-L-lysine (DGL) nanoparticles containing cis-aconitic anhydride-modified catalase and modified with PGP, an endogenous tripeptide that acts as a ligand with high affinity to neutrophils, were developed to form the cl PGP-PEG-DGL/CAT-Aco system...
2017: Theranostics
https://www.readbyqxmd.com/read/28886447/early-life-experience-contributes-to-the-developmental-programming-of-depressive-like-behaviour-neuroinflammation-and-oxidative-stress
#3
Gislaine Z Réus, Gabrielly C Fernandes, Airam B de Moura, Ritele H Silva, Ana Caroline Darabas, Thays G de Souza, Helena M Abelaira, Celso Carneiro, Diogo Wendhausen, Monique Michels, Bruna Pescador, Felipe Dal-Pizzol, Danielle S Macêdo, João Quevedo
This study used an animal model of depression induced by maternal care deprivation (MCD) to investigate whether depressive behaviour, neuroinflammation and oxidative stress were underlying factors in developmental programming after early life stress. At postnatal days (PND) 20, 30, 40, and 60, individual subsets of animals were evaluated in behavioural tests and then euthanized to assess cytokine levels and oxidative stress parameters in the prefrontal cortex (PFC), hippocampus and serum. The results showed that MCD did not induce behavioural changes at PND 30 and 40...
September 1, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/28876432/hospitalization-due-to-exacerbation-of-copd-real-life-outcomes
#4
Lilia Azzi Collet da Rocha Camargo, Maria Vera Oliveira Castellano, Fábio Checchia Ferreira, Flávio Vieira de Faria, Nelson Carvas
Introduction: Hospitalization due to chronic obstructive pulmonary disease exacerbation (eCOPD) may indicate worse prognosis. It is important to know the profile of hospitalized patients and their outcome of hospitalization to customize and optimize treatment. Method: Evaluation of patients hospitalized for eCOPD, with ≥ 10 pack/years and ≥ 1 previous spirometry with airway obstruction over the course of one year at the pulmonology service of a general hospital, applying: COPD assessment test (CAT); mMRc and Visual Analogue Scale (VAS) for dyspnea; hospitalized anxiety and depression questionnaire (HAD); Divo's comorbidities and Cote index; spirometry; and laboratory tests including number of eosinophils, C-reactive protein (CRP), brain natriuretic protein (BNP)...
June 2017: Revista da Associação Médica Brasileira
https://www.readbyqxmd.com/read/28875311/bisphenol-a-exposure-perturbs-visual-function-of-adult-cats-by-remodeling-the-neuronal-activity-in-the-primary-visual-pathway
#5
Guangwei Xu, Fan Hu, Xuan Wang, Bing Zhang, Yifeng Zhou
Bisphenol A (BPA), a common environmental xenoestrogen, has been implicated in physiological and behavioral impairment, but the neuronal basis remains elusive. Although various synaptic mechanisms have been shown to mediate BPA-induced brain deficits, there are almost no reports addressing its underlying physiological mechanisms at the individual neuron level, particularly in the primary visual system. In the present study, using multiple-channel recording technique, we recorded the responses of single neurons in the primary visual system of cats to various direction stimuli both before and after BPA exposure...
September 5, 2017: Archives of Toxicology
https://www.readbyqxmd.com/read/28867383/protective-effects-of-kinetin-against-aluminum-chloride-and-d-galactose-induced-cognitive-impairment-and-oxidative-damage-in-mouse
#6
Yunpeng Wei, Dan Liu, Yin Zheng, Honglian Li, Chaoshuang Hao, Wuqing Ouyang
Increasing evidence indicates that aluminum exposure and oxidative stress play crucial roles in the initiation and development of Alzheimer's disease (AD). Aluminum chloride (AlCl3) and d-galactose (d-gal) combined treatment of mice is considered as an easy and cheap way to obtain an animal model of AD. Kinetin is a plant cytokinin, which is also reported to exert neuro-protective effects in vivo and in vitro. Thus, in this study, neuro-protective effects of kinetin were investigated in an AD model of mice induced by AlCl3 and d-gal...
September 1, 2017: Brain Research Bulletin
https://www.readbyqxmd.com/read/28865890/natriuretic-propeptides-as-markers-of-atrial-fibrillation-burden-and-recurrence-from-the-amio-cat-trial
#7
Stine Darkner, Jens Peter Goetze, Xu Chen, Kristoffer Henningsen, Steen Pehrson, Jesper Hastrup Svendsen
Natriuretic peptides are established plasma markers of systolic heart failure, but their usefulness for the evaluation of atrial fibrillation (AF) is unknown. We examined mid-regional pro-atrial natriuretic peptide (MR-proANP) and N-terminal pro-brain natriuretic peptide (NT-proBNP) in patients undergoing ablation for AF. A subpopulation of 102 patients (median age 60 [52;65], 82% male) from the AMIO-CAT trial (Recurrence of arrhythmia following short-term oral AMIOdarone after CATheter ablation for atrial fibrillation: a double-blind, randomized, placebo-controlled study) undergoing ablation for paroxysmal (n = 55) or persistent (n = 47) AF was studied...
July 24, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28864874/close-interpersonal-proximity-modulates-visuomotor-processing-of-object-affordances-in-shared-social-space
#8
Elizabeth J Saccone, Ancret Szpak, Owen Churches, Michael E R Nicholls
Research suggests that the human brain codes manipulable objects as possibilities for action, or affordances, particularly objects close to the body. Near-body space is not only a zone for body-environment interaction but also is socially relevant, as we are driven to preserve our near-body, personal space from others. The current, novel study investigated how close proximity of a stranger modulates visuomotor processing of object affordances in shared, social space. Participants performed a behavioural object recognition task both alone and with a human confederate...
September 1, 2017: Attention, Perception & Psychophysics
https://www.readbyqxmd.com/read/28854184/exploring-virulence-and-immunogenicity-in-the-emerging-pathogen-sporothrix-brasiliensis
#9
Paula Portella Della Terra, Anderson Messias Rodrigues, Geisa Ferreira Fernandes, Angela Satie Nishikaku, Eva Burger, Zoilo Pires de Camargo
Sporotrichosis is a polymorphic chronic infection of humans and animals classically acquired after traumatic inoculation with soil and plant material contaminated with Sporothrix spp. propagules. An alternative and successful route of transmission is bites and scratches from diseased cats, through which Sporothrix yeasts are inoculated into mammalian tissue. The development of a murine model of subcutaneous sporotrichosis mimicking the alternative route of transmission is essential to understanding disease pathogenesis and the development of novel therapeutic strategies...
August 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28846745/comparison-of-cognitive-and-brain-grey-matter-volume-profiles-between-multiple-sclerosis-and-neuromyelitis-optica-spectrum-disorder
#10
Hiroki Masuda, Shigeki Hirano, Nobuyoshi Takahashi, Etsuko Hatsugano, Akiyuki Uzawa, Tomohiko Uchida, Ryohei Ohtani, Satoshi Kuwabara, Masahiro Mori
OBJECTIVE: Brain regions responsible for cognitive dysfunction in MS and neuromyelitis optica spectrum disorder (NMOSD) are not known. Our aim of this study was to investigate whether cognitive function and brain volume differed between MS and NMOSD in Japanese patients. METHODS: Brain MRI and neuropsychological tests including the Wechsler Adult Intelligence Scale-III (WAIS-III), Wechsler Memory Scale-Revised (WMS-R), Trail Making Test (TMT) and Clinical Assessment for Attention (CAT) were performed...
2017: PloS One
https://www.readbyqxmd.com/read/28843649/change-in-nomenclature-for-the-immunologic-synapse-from-troxis-necrosis-to-trogocytosis
#11
Samuel W French
The immunologic synapse mechanism of liver necrosis was termed Troxis Necrosis meaning "nibbling". (Wang MX et al. and French SW. Exp Mol Pathol 2001, 71: 137-146). This mechanism of liver injury was first named "Piecemeal Necrosis" by Hans Popper. It is involved in autoimmune hepatitis, HCV, HBV, primary biliary cirrhosis and steatohepatitis. This process involves the T cell receptor (TCR) which binds to the hepatocyte antigen presenting major histocompatibility complex (MHC) on the hepatocytic plasma membrane which quickly leads to the removal of the complex from the liver and uptake by the CD4 lymphocyte...
August 24, 2017: Experimental and Molecular Pathology
https://www.readbyqxmd.com/read/28833532/the-relationship-between-brachycephalic-head-features-in-modern-persian-cats-and-dysmorphologies-of-the-skull-and-internal-hydrocephalus
#12
M J Schmidt, M Kampschulte, S Enderlein, D Gorgas, J Lang, E Ludewig, A Fischer, A Meyer-Lindenberg, A R Schaubmar, K Failing, N Ondreka
BACKGROUND: Cat breeders observed a frequent occurrence of internal hydrocephalus in Persian cats with extreme brachycephalic head morphology. OBJECTIVE: To investigate a possible relationship among the grade of brachycephaly, ventricular dilatation, and skull dysmorphologies in Persian cats. ANIMALS: 92 Persian-, 10 Domestic shorthair cats. METHODS: The grade of brachycephaly was determined on skull models based on CT datasets...
September 2017: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/28811686/influence-of-the-flavonoid-quercetin-on-antioxidant-status-lipid-peroxidation-and-histopathological-changes-in-hyperammonemic-rats
#13
Sivamani Kanimozhi, Pakkiri Bhavani, Perumal Subramanian
We have studied the ability of quercetin (a bioflavonoid) in tackling oxidative stress to alleviate the symptoms during ammonium chloride-induced hyperammonemia. Hyperammonemia was induced by the treatment of ammonium chloride (AC) 100 mg/kg b.w for 56 days. Hyperammonemic rats exhibited reduced urea (in plasma) and increased ammonia (in blood), uric acid (in plasma), creatinine (in serum), oxidative stress markers (thiobarbituric acid reactive substances (TBARS) and hydroperoxides (HP) and decreased levels of antioxidants (enzymatic and non-enzymatic) superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), reduced glutathione (GSH) in plasma and tissues (liver and brain) vitamins E and C (in plasma))...
July 2017: Indian Journal of Clinical Biochemistry: IJCB
https://www.readbyqxmd.com/read/28810533/deltamethrin-induced-oxidative-stress-in-kidney-and-brain-of-rats-protective-effect-of-artemisia-campestris-essential-oil
#14
Mongi Saoudi, Riadh Badraoui, Houda Bouhajja, Marwa Ncir, Fatma Rahmouni, Malek Grati, Kamel Jamoussi, Abdelfattah El Feki
Artemisia campestris (Asteraceae) is widely used in traditional medicine in Southern Tunisia as a decoction for its antivenom, anti-inflammatory, antirheumatic, and antimicrobial activities. A. campestris essential oil (ACEO) was obtained by hydrodistillation from the aerial parts, since it has beneficial and therapeutic effects. Deltamethrin is a synthetic pyrethroid with broad spectrum activities against acaricides and insects and widely used for veterinary and agricultural purposes. Exposure to deltamethrin leads to nephrotoxic and neurotoxic side effects for human and many species including birds and fish...
August 11, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28810519/the-beneficial-role-of-naringin-a-citrus-bioflavonoid-against-oxidative-stress-induced-neurobehavioral-disorders-and-cognitive-dysfunction-in-rodents-a-systematic-review-and-meta-analysis
#15
REVIEW
Gollapalle Lakshminarayanashastry Viswanatha, H Shylaja, Yogananda Moolemath
OBJECTIVES: Naringin is a bioflavonoid, very abundantly found in citrus species. In literature, naringin has been scientifically well documented for its beneficial effects in various neurological disorders. In this systematic review and meta-analysis, we have made an attempt to correlate the protective role of naringin against oxidative stress-induced neurological disorders in rodents. METHODS: The systematic search was performed using electronic databases; the search was mainly focused on the role of naringin in oxidative stress-induced neuropathological conditions in rodents...
August 10, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28809861/high-frequency-measurement-of-depressive-severity-in-a-patient-treated-for-severe-treatment-resistant-depression-with-deep-brain-stimulation
#16
S Sani, J Busnello, R Kochanski, Y Cohen, R D Gibbons
Although there have been previous studies of deep-brain stimulation (DBS), we present, to our knowledge, the first example of high-frequency depressive severity measurement-based DBS treatment in particular and psychiatric treatment in general. Daily post-surgical e-mail prompts for a period of 6 months resulted in 93 administrations of a computerized adaptive test (CAT) of depression severity (CAT-Depression Inventory or CAT-DI) via the internet. There was an average of 3.37 weekly measurements with an average separation of 2...
August 15, 2017: Translational Psychiatry
https://www.readbyqxmd.com/read/28799110/alteration-of-membrane-integrity-and-respiratory-function-of-brain-mitochondria-in-the-rats-chronically-exposed-to-a-low-dose-of-acetamiprid
#17
Salim Gasmi, Mohammed Kebieche, Rachid Rouabhi, Chouaib Touahria, Asma Lahouel, Zohra Lakroun, Sara Henine, Rachid Soulimani
The pesticides are used in several fields of agriculture and farms to protect crops against harmful insects and herbs. The increased and uncontrolled use of these pollutants is very hazardous for the population health. Consumption of contaminated food matrices with these pesticides could impair the cell integrity and its molecular function. The main aim of this present study was to evaluate the alteration of the integrity of mitochondrial membranes and respiratory chain potential in the brain of rats exposed during 90 days to acetamiprid (AC), organochlorine of the new generation...
August 10, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28797854/why-computerized-adaptive-testing-in-pediatric-brain-tumor-clinics
#18
Jin-Shei Lai, Jennifer L Beaumont, Cindy J Nowinski, David Cella, William F Hartsell, John Han-Chih Chang, Peter E Manley, Stewart Goldman
CONTEXT: Monitoring of health-related quality of life (HRQOL) and symptoms of patients with brain tumors is needed yet not always feasible. This is partially due to lack of brief-yet-precise assessments with minimal administration burden that are easily incorporated into clinics. Dynamic computerized adaptive testing (CAT) or static fixed-length short-forms, derived from psychometrically-sound item banks, are designed to fill this void. OBJECTIVE: This study evaluated the comparability of scores obtained from CATs and short-forms...
August 7, 2017: Journal of Pain and Symptom Management
https://www.readbyqxmd.com/read/28791002/antibody-detection-isolation-genotyping-and-virulence-of-toxoplasma-gondii-in-captive-felids-from-china
#19
Yu-Rong Yang, Yong-Jie Feng, Yao-Yao Lu, Hui Dong, Tong-Yi Li, Yi-Bao Jiang, Xing-Quan Zhu, Long-Xian Zhang
The felids are the only definitive hosts of Toxoplasma gondii, which could excrete oocysts into the environment and provide an infection source for toxoplasmosis in various warm-blooded animal species, particularly the captive felids that live close to human communities. The infection rate of the captive felids is a perfect standard in detecting the presence of Toxoplasma gondii oocysts in the environment. In this study, sera or tissue samples from zoo (1 young tiger, 2 adult tigers, 6 young lions), farm (10 masked palm civets), and pet hospital (28 cats) from Henan Province (China) were collected...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28772233/functional-mri-based-identification-of-brain-regions-activated-by-mechanical-noxious-stimulation-and-modulatory-effect-of-remifentanil-in-cats
#20
Dai Nagakubo, Yuji Hamamoto, Daisuke Hasegawa, Masatoshi Kamata, Tomoya Iizuka, Kanako Muta, Naoki Fujita, Takayuki Nakagawa, Ryohei Nishimura
This study was conducted to identify the brain regions corresponding to mechanical noxious stimulation in cats using functional magnetic resonance imaging (fMRI) and to investigate the modulatory effect of remifentanil on the activation of these regions. Six healthy cats were anesthetized using a constant-rate infusion of alfaxalone. Cats were allocated to one of three treatment groups: remifentanil 0 (saline), 0.25, and 0.5μg/kg/min. A 3.0-T MRI unit was used to collect fMRI data. During the fMRI scanning, mechanical noxious stimulation was applied by tail clamping...
July 24, 2017: Research in Veterinary Science
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