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https://www.readbyqxmd.com/read/29331520/vitamin-c-attenuates-biochemical-and-genotoxic-damage-in-common-carp-cyprinus-carpio-upon-joint-exposure-to-combined-toxic-doses-of-fipronil-and-buprofezin-insecticides
#1
Madiha Ghazanfar, Sana Shahid, Irfan Zia Qureshi
In the present study, potential protective role of Vitamin C (l-ascorbic acid) was investigated in aquaria acclimated common carp (Cyprinus carpio) following exposure for 96 h to combined toxic doses of fipronil (FP) and buprofezin (BPFN) insecticides in combination (FP: 200 μg/L; 4.57 × 10-7 mol/L and BPFN: 50 mg/L; 1.64 × 10-4 mol/L). At end of 96 h exposure, fish were supplemented with low (25 mg/L) and high (50 mg/L) doses of Vitamin C, added once daily to aquaria water for continuous three weeks...
January 5, 2018: Aquatic Toxicology
https://www.readbyqxmd.com/read/29317251/organoselenium-group-is-critical-for-antioxidant-activity-of-7-chloro-4-phenylselenyl-quinoline
#2
Ane G Vogt, Guilherme T Voss, Renata L de Oliveira, Jaini J Paltian, Luis F B Duarte, Diego Alves, Cristiano R Jesse, Silvane S Roman, Juliano A Roehrs, Ethel A Wilhelm, Cristiane Luchese
The quinolone compounds have been reported for many biological properties, especially as potent antioxidants. This study investigated the antioxidant effect of 7-chloro-4-phenylselenyl-quinoline (PSQ), a quinolone derivative with organoselenium group, against oxidative stress induced by sodium nitroprusside (SNP) in brains of mice. A second objective was to verify the importance of phenylselenyl group presents at position 4 of the quinoline structure to antioxidant effect of compound. So, it was compared the antioxidant effect of PSQ with a quinoline without organoseleniun group (7-chloroquinoline [QN])...
January 6, 2018: Chemico-biological Interactions
https://www.readbyqxmd.com/read/29317239/protective-effect-of-mitochondrial-targeted-antioxidant-mitoq-against-iron-ion-56fe-radiation-induced-brain-injury-in-mice
#3
Lu Gan, Zhenhua Wang, Jing Si, Rong Zhou, Chao Sun, Yang Liu, Yancheng Ye, Yanshan Zhang, Zhiyuan Liu, Hong Zhang
Exposure to iron ion 56Fe radiation (IR) during space missions poses a significant risk to the central nervous system and radiation exposure is intimately linked to the production of reactive oxygen species (ROS). MitoQ is a mitochondria-targeted antioxidant that has been shown to decrease oxidative damage and lower mitochondrial ROS in a number of animal models. Therefore, the present study aimed to investigate role of the mitochondrial targeted antioxidant MitoQ against 56Fe particle irradiation-induced oxidative damage and mitochondria dysfunction in the mouse brains...
January 6, 2018: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/29310227/quantitative-analysis-of-drug-distribution-by-ambient-mass-spectrometry-imaging-method-with-signal-extinction-normalization-strategy-and-inkjet-printing-technology
#4
Zhigang Luo, Jingjing He, Jiuming He, Lan Huang, Xiaowei Song, Xin Li, Zeper Abliz
Quantitative mass spectrometry imaging (MSI) is a robust approach that provides both quantitative and spatial information for drug candidates' research. However, because of complicated signal suppression and interference, acquiring accurate quantitative information from MSI data remains a challenge, especially for whole-body tissue sample. Ambient MSI techniques using spray-based ionization appear to be ideal for pharmaceutical quantitative MSI analysis. However, it is more challenging, as it involves almost no sample preparation and is more susceptible to ion suppression/enhancement...
March 1, 2018: Talanta
https://www.readbyqxmd.com/read/29302617/genetic-pathways-of-neuroregeneration-in-a-novel-mild-traumatic-brain-injury-model-in-adult-zebrafish
#5
Amanda L Maheras, Brian Dix, Olivia M S Carmo, Aleena E Young, Vanessa N Gill, Julia L Sun, Aleah R Booker, Helen A Thomason, Anastasia E Ibrahim, Lauren Stanislaw, Jennifer C Dallego, Cat N Ngo, Audrey Chen, Barbara K Fortini, Rory D Spence
Mild traumatic brain injuries (mTBIs) are one of the most prevalent neurological disorders, and humans are severely limited in their ability to repair and regenerate central nervous system (CNS) tissue postinjury. However, zebrafish (Danio rerio) maintain the remarkable ability to undergo complete and functional neuroregeneration as an adult. We wish to extend knowledge of the known mechanisms of neuroregeneration by analyzing the differentially expressed genes (DEGs) in a novel adult zebrafish model of mTBI...
January 2018: ENeuro
https://www.readbyqxmd.com/read/29295636/caffeine-prevents-bilirubin-induced-cytotoxicity-in-cultured-newborn-rat-astrocytes
#6
Mehmet Deliktaş, Hacer Ergin, Aydın Demiray, Hakan Akça, Özmert M A Özdemir, Mehmet Bülent Özdemir
OBJECTIVE: Unconjugated bilirubin (UCB) may cause neurotoxicity in preterm neonates due to immaturity of UGT1A1 leading to bilirubin accumulation in the brain. Caffeine used in the treatment of apnea of prematurity was reported to decrease mechanical ventilation requirement, the frequencies of bronchopulmonary dysplasia, patent ductus arteriosus, cerebral palsy and neurodevelopmental disorders in very low birth weight infants. However, the effect of caffeine on hyperbilirubinemia was not yet clarified...
January 2, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29290043/the-effects-of-vitamin-e-on-brain-derived-neurotrophic-factor-tissues-oxidative-damage-and-learning-and-memory-of-juvenile-hypothyroid-rats
#7
Yousef Baghcheghi, Farimah Beheshti, Mohammad Naser Shafei, Hossein Salmani, Hamid Reza Sadeghnia, Mohammad Soukhtanloo, Akbar Anaeigoudari, Mahmoud Hosseini
The effects of vitamin E (Vit E) on brain derived neurotrophic factor (BDNF) and brain tissues oxidative damage as well as on learning and memory impairments in juvenile hypothyroid rats were examined. The rats were grouped as: (1) Control; (2) Propylthiouracil (PTU); (3) PTU-Vit E and (4) Vit E. PTU was added to their drinking water (0.05%) during 6 weeks. Vit E (20 mg/kg) was daily injected (IP). Morris water maze (MWM) and passive avoidance (PA) were carried out. The animals were deeply anesthetized and the brain tissues were removed for biochemical measurements...
December 30, 2017: Metabolic Brain Disease
https://www.readbyqxmd.com/read/29279081/toxoplasma-gondii-a-study-of-oocyst-re-shedding-in-domestic-cats
#8
Dauton Luiz Zulpo, Ana Sue Sammi, Joeleni Rosa Dos Santos, João Pedro Sasse, Thais Agostinho Martins, Ana Flávia Minutti, Sérgio Tosi Cardim, Luiz Daniel de Barros, Italmar Teodorico Navarro, João Luis Garcia
The aim of the present study was to evaluate the re-shedding of T. gondii oocysts in cats fed tissue cysts of homologous and heterologous strains 12, 24 and 36 months after the first infection. Thirteen cats were used in the present study and were divided into four groups: G1 (n=2), G2 (n=3), G3 (n=5), and G4 (n=3). G1, G3 and G4 cats were infected with brain cysts of ME49 and G2 with TgDoveBr8, both genotype II strains of T. gondii. The G1 and G2 cats were re-infected after twelve months with brain cysts of VEG strain (genotype III), and G3 cats were re-infected with TgDoveBr1 (genotype II)...
January 15, 2018: Veterinary Parasitology
https://www.readbyqxmd.com/read/29279026/cortical-visual-connections-via-the-corpus-callosum-are-asymmetrical-in-human-infantile-esotropia
#9
Marcel P M Ten Tusscher, Anne Cees Houtman, Johan De Mey, Peter Van Schuerbeek
PURPOSE: Besides chiasmal hemidecussation, interhemispheric connections are likely important in human binocularity. The corpus callosum (CC) is the major fiber bundle in the mammalian brain which mostly connects homologous cortical areas in the two hemispheres. Visual interhemispheric connections were found abnormal in strabismic cats. No studies have investigated these pathways in humans with infantile strabismus. METHODS: Diffusion tensor imaging was used in four subjects with infantile esotropia (IE) and nine control subjects with normal binocularity, in order to study interhemispheric fibers in the CC connecting the right and left primary visual cortical areas...
December 26, 2017: Strabismus
https://www.readbyqxmd.com/read/29277119/brain-derived-neurotropic-factor-bdnf-heterozygous-mice-are-more-susceptible-to-synaptic-protein-loss-in-cerebral-cortex-during-high-fat-diet
#10
İsmail Abidin, Selcen Aydin-Abidin, Akin Bodur, İmran İnce, Ahmet Alver
In this study we aimed to investigate whether reduced BDNF levels aggravate the susceptibility of the brain to hazardous effects of high fat diet. For this purpose, we fed BDNF heterozygous mice and wild type littermates with normal and high fat diet for 16 weeks. Concentrations of two synaptic proteins (SNAP-25 and PSD-95) and oxidative stress parameters (MDA, SOD, CAT) were evaluated in the cortex after diet period. Interestingly, body weights of BDNF heterozygous groups fed with control diet were higher than their littermates and heterozygous mice fed with HFD were the heaviest in all experimental groups...
December 25, 2017: Archives of Physiology and Biochemistry
https://www.readbyqxmd.com/read/29276216/malva-sylvestris-attenuates-cognitive-deficits-in-a-repetitive-mild-traumatic-brain-injury-rat-model-by-reducing-neuronal-degeneration-and-astrocytosis-in-the-hippocampus
#11
Hailin Qin, Jie Qin, Junmin Hu, He Huang, Lianting Ma
BACKGROUND The aim of our study was to evaluate the effect of Malva sylvestris (MS) on cognitive dysfunction in a repetitive mild traumatic brain injury (MTBI). MATERIAL AND METHODS MTBI was induced in all the study animals by hitting a metallic pendulum near the parietal-occipital area of the skull three times a day for ten days. Animals were treated with MS (250 mg/kg and 500 mg/kg) intragastrically per day for seven consecutive days. Cognitive function was estimated by the Morris water maze (MWM) method...
December 25, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29261511/biomechanistic-insights-into-the-roles-of-oxidative-stress-in-generating-complex-neurological-disorders
#12
Mohammad Yusuf, Maria Khan, Majed A Robaian, Riaz A Khan
Neurological diseases like Alzheimer's, epilepsy, Parkinsonism, depression, Huntington's disease, and amyotrophic lateral sclerosis prevailing globally are considered to be deeply influenced by oxidative stress based changes in the biochemical settings of the organs. The excess oxygen concentration triggers the production of reactive oxygen species and even the intrinsic antioxidant enzyme system, i.e., SOD, CAT and GSHPx fails to manage their levels and keep them under desirable limits. This consequently leads to oxidation of protein, lipids, and nucleic acids in the brain resulting in apoptosis, proteopathy, proteasomes and mitochondrion dysfunction, glial cell activation as well as neuroinflammation...
June 27, 2017: Biological Chemistry
https://www.readbyqxmd.com/read/29250976/attenuation-of-brain-mitochondria-oxidative-damage-by-albizia-julibrissin-durazz-neuroprotective-and-antiemetic-effects
#13
Mohammad Ali Ebrahimzadeh, Hamed Fathi, Ali Ziar, Hamidreza Mohammadi
Medicinal plants, as new drugs, are considered for treatment of insomnia, anxiety, depression, confusion, nausea, and vomiting symptoms. The current study aimed to evaluate the neuroprotective and antiemetic effects of Albizia. julibrissin Durazz. flower extract in the chickens. Emesis was induced by copper sulfate and ipecac (60 and 600 mg/kg, orally, respectively) and the methanolic extract (50, 100, and 200 mg/kg) were injected intraperitoneally (i.p.). Mitochondrial function, lipid peroxidation (LPO), protein carbonyl (PC) content, and catalase activity as biomarkers of oxidative damage were evaluated in the brain mitochondria...
December 18, 2017: Drug and Chemical Toxicology
https://www.readbyqxmd.com/read/29249925/determining-excitatory-and-inhibitory-neuronal-activity-from-multimodal-fmri-data-using-a-generative-hemodynamic-model
#14
Martin Havlicek, Dimo Ivanov, Alard Roebroeck, Kamil Uludağ
Hemodynamic responses, in general, and the blood oxygenation level-dependent (BOLD) fMRI signal, in particular, provide an indirect measure of neuronal activity. There is strong evidence that the BOLD response correlates well with post-synaptic changes, induced by changes in the excitatory and inhibitory (E-I) balance between active neuronal populations. Typical BOLD responses exhibit transients, such as the early-overshoot and post-stimulus undershoot, that can be linked to transients in neuronal activity, but they can also result from vascular uncoupling between cerebral blood flow (CBF) and venous cerebral blood volume (venous CBV)...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29247305/neurologic-disease-in-feline-immunodeficiency-virus-infection-disease-mechanisms-and-therapeutic-interventions-for-neuroaids
#15
Christopher Power
Feline immunodeficiency virus (FIV) is a lentivirus that causes immunosuppression through virus-mediated CD4+ T cell depletion in feline species. FIV infection is complicated by virus-induced disease in the nervous system. FIV enters the brain soon after primary infection and is detected as FIV-encoded RNA, DNA, and proteins in microglia, macrophages, and astrocytes. FIV infection activates neuroinflammatory pathways including cytokines, chemokines, proteases, and ROS with accompanying neuronal injury and loss...
December 15, 2017: Journal of Neurovirology
https://www.readbyqxmd.com/read/29245273/a-delayed-diagnosis-of-x-linked-hyper-igm-syndrome-complicated-with-toxoplasmic-encephalitis-in-a-child-a-case-report-and-literature-review
#16
Xiaoliang Liu, Kaiyu Zhou, Dan Yu, Xiaotang Cai, Yimin Hua, Hui Zhou, Chuan Wang
INTRODUCTION: The X-linked hyper-immunoglobulin M syndrome (XHIGM) is an uncommon primary combined immunodeficiency disease caused by CD40L gene mutations. A delayed or missed diagnosis of XHIGM is common and concerning, owing to atypical immunoglobulin profile and phenotype of some patients, low recognition, and limited knowledge of clinicians on XHIGM in some underdeveloped areas. Opportunistic infections are a prominent clinical feature of XHIGM. However, toxoplasma encephalitis occurs sporadically and is extremely rare in patients with XHIGM...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29230640/new-class-of-reduced-computationally-efficient-neuronal-models-for-large-scale-simulations-of-brain-dynamics
#17
Maxim Komarov, Giri Krishnan, Sylvain Chauvette, Nikolai Rulkov, Igor Timofeev, Maxim Bazhenov
During slow-wave sleep, brain electrical activity is dominated by the slow (< 1 Hz) electroencephalogram (EEG) oscillations characterized by the periodic transitions between active (or Up) and silent (or Down) states in the membrane voltage of the cortical and thalamic neurons. Sleep slow oscillation is believed to play critical role in consolidation of recent memories. Past computational studies, based on the Hodgkin-Huxley type neuronal models, revealed possible intracellular and network mechanisms of the neuronal activity during sleep, however, they failed to explore the large-scale cortical network dynamics depending on collective behavior in the large populations of neurons...
December 12, 2017: Journal of Computational Neuroscience
https://www.readbyqxmd.com/read/29228782/antioxidant-defence-in-the-brain-of-one-day-old-chickens-exposed-in-ovo-to-acrylamide
#18
M Batoryna, M W Lis, G Formicki
1. Acrylamide (ACR) is a potent neurotoxicant, although information on its toxic influence on the developing neural system is still limited. We examined the effect of in-ovo-injected ACR on the antioxidant system activity in the brain of new hatched chickens. This model eliminated the mother's contribution to embryonic development. It was also recognised as an adequate model for animal embryonic development. 2. ACR was injected on day 4 of embryogenesis- in doses of 1.25 and 2.50 mg per egg (n=40 eggs per group/120 eggs)...
December 12, 2017: British Poultry Science
https://www.readbyqxmd.com/read/29223124/activation-of-mitochondrial-katp-channels-mediates-neuroprotection-induced-by-chronic-morphine-preconditioning-in-hippocampal-ca-1-neurons-following-cerebral-ischemia
#19
Maedeh Arabian, Nahid Aboutaleb, Mansoureh Soleimani, Marjan Ajami, Rouhollah Habibey, Hamidreza Pazoki-Toroudi
PURPOSE: Pharmacologic preconditioning, through activating several mechanisms and mediators, can increase the tolerance of different tissues against ischemia/reperfusion (I/R) injury. Recent studies have shown that morphine preconditioning has protective effects in different organs, especially in the heart. Nevertheless, its mechanisms are not well elucidated in the brain. The present study aimed to clarify whether the activation of mitochondrial KATP (mKATP) channels in chronic morphine (CM) preconditioning could decrease hippocampus damage following I/R injury...
December 6, 2017: Advances in Medical Sciences
https://www.readbyqxmd.com/read/29214257/piceatannol-attenuates-behavioral-disorder-and-neurological-deficits-in-aging-mice-via-activating-the-nrf2-pathway
#20
Yan Zhang, Li-Hong Zhang, Xi Chen, Ning Zhang, Guang Li
Aging is a complex process that is accompanied by neurological damage. Chronic injection of d-galactose (d-gal) can accelerate the aging process similar to natural aging and is commonly used to build an aging model to investigate aging. In the present study, the effects of piceatannol on d-gal-induced aging in mice were evaluated. Piceatannol treatment showed an observable anti-aging effect. Results obtained in vivo showed that piceatannol retained spontaneous motor activity and enhanced spatial learning and memory abilities in mice in which aging was induced by d-gal...
December 7, 2017: Food & Function
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