Geoffrey Hinsinger, Lucile Du Trieu De Terdonck, Serge Urbach, Nicolas Salvetat, Manon Rival, Manon Galoppin, Chantal Ripoll, Renaud Cezar, Sabine Laurent-Chabalier, Christophe Demattei, Hanane Agherbi, Giovanni Castelnovo, Sylvain Lehmann, Valérie Rigau, Philippe Marin, Eric Thouvenot
BACKGROUND AND OBJECTIVES: The aim of this study was to identify novel biomarkers for multiple sclerosis (MS) diagnosis and prognosis, addressing the critical need for specific and prognostically valuable markers in the field. METHODS: We conducted an extensive proteomic investigation, combining analysis of (1) CSF proteome from symptomatic controls, fast and slow converters after clinically isolated syndromes, and patients with relapsing-remitting MS (n = 10 per group) using label-free quantitative proteomics and (2) oligodendrocyte secretome changes under proinflammatory or proapoptotic conditions using stable isotope labeling by amino acids in cell culture...
May 2024: Neurology® Neuroimmunology & Neuroinflammation