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https://www.readbyqxmd.com/read/29448339/cooperative-behavior-of-molecular-motions-giving-rise-to-two-glass-transitions-in-the-same-supercooled-mesophase-of-a-smectogenic-liquid-crystal-dimer
#1
David O López, Josep Salud, María Rosario de la Fuente, Nerea Sebastián, Sergio Diez-Berart
In the present work, a detailed analysis of the glassy behavior and the relaxation dynamics of the liquid crystal dimer α-(4-cyanobiphenyl-4'-yloxy)-ω-(1-pyrenimine-benzylidene-4'-oxy) heptane (CBO7O.Py) throughout both nematic and smectic-A mesophases by means of broadband dielectric spectroscopy has been performed. CBO7O.Py shows three different dielectric relaxation modes and two glass transition (T_{g}) temperatures: The higher T_{g} is due to the freezing of the molecular motions responsible for the relaxation mode with the lowest frequency (μ_{1L}); the lower T_{g} is due to the motions responsible for the two relaxation modes with highest frequencies (μ_{1H} and μ_{2}), which converge just at their corresponding T_{g}...
January 2018: Physical Review. E
https://www.readbyqxmd.com/read/29410171/how-fragile-are-clinical-trial-outcomes-that-support-the-chest-clinical-practice-guidelines-for-venous-thromboembolism
#2
Elizabeth Edwards, Cole Wayant, Jonathan Besas, Justin Chronister, Matt Vassar
BACKGROUND: Venous thromboembolism (VTE) remains a health concern for global populations. Clinical practice guidelines are necessary to guide physicians in the prophylaxis and treatment of VTE. METHODS: Our investigation assessed the robustness of the underlying evidence in 21 randomized controlled trials (RCTs) used to support treatment recommendations in the 2016 CHEST Guideline and Expert Panel Report on Antithrombotic Therapy for VTE Disease. We calculated the fragility index and fragility quotient for qualifying outcomes within RCTs...
February 1, 2018: Chest
https://www.readbyqxmd.com/read/29394101/risperidone-treatment-for-irritability-in-fragile-x-syndrome
#3
Kelli C Dominick, Logan K Wink, Ernest V Pedapati, Rebecca Shaffer, John A Sweeney, Craig A Erickson
OBJECTIVE: The goal of this study was to assess the effectiveness of risperidone monoantipsychotic therapy targeting irritability in patients with Fragile X syndrome (FXS) in a naturalistic outpatient clinical setting. METHODS: We examined the use of risperidone, predominantly in combination with other nonantipsychotic psychotropic agents, targeting irritability in 21 male patients with FXS with a retrospective analysis of a prospectively collected large developmental disabilities-specific treatment database...
February 2, 2018: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/29391054/supar-is-associated-with-risk-of-future-acute-surgery-and-post-operative-mortality-in-acutely-admitted-medical-patients
#4
Jeppe Meyer, Morten Alstrup, Line J H Rasmussen, Martin Schultz, Steen Ladelund, Thomas H Haupt, Jens Tingleff, Kasper Iversen, Jesper Eugen-Olsen
BACKGROUND: Acutely admitted medical patients are often fragile and in risk of future surgery. The biomarker soluble urokinase plasminogen activator receptor (suPAR) is a predictor of readmission and mortality in the acute care setting. We aimed to investigate if suPAR also predicts acute surgery, which is associated with higher mortality than elective surgery, and if it predicts post-operative mortality. METHODS: A retrospective registry-based cohort study of 17,312 patients admitted to an acute medical unit in Denmark, from 18 November 2013 until 30 September 2015...
February 1, 2018: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine
https://www.readbyqxmd.com/read/29389010/changes-in-bone-mineral-density-and-bone-turnover-markers-during-treatment-with-teriparatide-in-pregnancy-and-lactation-associated-osteoporosis
#5
Namki Hong, Jo Eun Kim, Su Jin Lee, Se Hwa Kim, Yumie Rhee
CONTEXT: Teriparatide (TPTD) therapy has been proposed as a potential treatment strategy in severe cases of pregnancy- and lactation-associated osteoporosis (PLO) characterised by the occurrence of fragility fractures in the third trimester or early postpartum. OBJECTIVE: To investigate the changes in bone mineral density (BMD) and bone turnover markers in patients with PLO with and without TPTD treatment. DESIGN: Retrospective cohort study...
February 1, 2018: Clinical Endocrinology
https://www.readbyqxmd.com/read/29387910/bone-density-and-microarchitecture-in-hepatitis-c-and-hiv-coinfected-postmenopausal-minority-women
#6
M T Yin, A RoyChoudhury, K Nishiyama, T Lang, J Shah, S Olender, D C Ferris, C Zeana, A Sharma, B Zingman, M Bucovsky, I Colon, E Shane
We found that HIV+/HCV+ women had 7-8% lower areal bone mineral density (aBMD) by dual-energy x-ray absorptiometry (DXA) at the spine, hip, and radius (p < 0.01) and 5-7% lower volumetric BMD (vBMD) by central quantitative computed tomography (cQCT) at the spine and hip (p < 0.05). These data suggest that true deficits in vBMD may contribute to bone fragility and excess fractures reported in HIV+/HCV+ women. INTRODUCTION: aBMD by DXA is lower in persons coinfected with HIV and HCV (HIV+/HCV+) than with HIV monoinfection (HIV+)...
February 1, 2018: Osteoporosis International
https://www.readbyqxmd.com/read/29384682/determination-of-fragility-in-organic-small-molecular-glass-forming-liquids-comparison-of-calorimetric-and-spectroscopic-data-and-commentary-on-pharmaceutical-importance
#7
Paroma Chakravarty, Keyurkumar Pandya, Karthik Nagapudi
The fragility index (m) and conversely the strength parameter (D) are widely used to categorize glass forming liquids and are used to characterize temperature-dependency of viscosity and relaxation time as the supercooled liquid approaches glass transition. The currently used calorimetric methods in pharmaceutical literature lead to wide variability in measured values of m. In this work, a modulated differential scanning calorimetry (DSC) method is introduced that can directly determine m with minimal variability...
January 31, 2018: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/29369077/is-there-an-optimum-duration-of-fluid-bolus-in-pediatric-septic-shock-a-critical-appraisal-of-fluid-bolus-over-15-20-versus-5-10-minutes-each-in-the-first-hour-of-resuscitation-in-children-with-septic-shock-a-randomized-controlled-trial-by-sankar-et-al-pediatr
#8
Mark J Russell, Hari Krishnan Kanthimathinathan
OBJECTIVES: To review the findings and discuss the implications of a longer duration for fluid boluses in the resuscitation of children with septic shock. DATA SOURCES: We performed a PubMed.gov search using the criteria "Fluid Bolus" and "Children" and "Septic Shock," which yielded 29 references. STUDY SELECTION: One trial compared different durations of fluid boluses in pediatric septic shock and was therefore selected for critical appraisal...
January 23, 2018: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/29368309/are-we-treating-osteoporotic-fractures-of-the-hip-adequately-a-middle-eastern-cohort-study
#9
K Venugopal Menon, Huda Hamed Salim Al Harthy, Khalid Shafi Khalid Al Habsi, Hind Abdullah Hamed Al Ruzaiqi
Fragility hip fractures treated in a center in the Middle East were retrospectively studied for adequacy of osteoporosis management. Of the 318 patients treated, over 70% did not have a structured investigation and about 30% did not receive any therapeutic supplements. Our series showed a preventable 8.8% secondary fracture rate. PURPOSE: To study the adequacy of evaluation and treatment of osteoporosis after fragility fractures of the hip. The study also attempts to estimate the prevalence of secondary fractures after the original injury...
January 24, 2018: Archives of Osteoporosis
https://www.readbyqxmd.com/read/29364518/protective-effect-of-denosumab-on-bone-in-older-women-with-primary-hyperparathyroidism
#10
Cristina Eller-Vainicher, Serena Palmieri, Elisa Cairoli, Giovanni Goggi, Alfredo Scillitani, Maura Arosio, Alberto Falchetti, Iacopo Chiodini
OBJECTIVES: To determine the effect of denosumab, which is used in primary osteoporosis (PO), in primary hyperparathyroidism (PHPT)-related osteoporosis. DESIGN: Retrospective, longitudinal study. SETTING: Outpatient osteoporosis clinic. PARTICIPANTS: Older women with PHPT (78.6 ± 5.5) (n = 25) and PO (78.8 ± 5.2) (n = 25) matched on age, body mass index, familial history of hip fracture, femoral bone mineral density (BMD), and personal history of fragility fractures...
January 24, 2018: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/29348038/children-with-fragile-x-syndrome-display-threat-specific-biases-toward-emotion
#11
Jessica L Burris, Ryan A Barry-Anwar, Riley N Sims, Randi J Hagerman, Flora Tassone, Susan M Rivera
BACKGROUND: Fragile X syndrome (FXS) is the most common form of inherited intellectual disability. FXS is caused by a silencing of the FMR1 gene that results in a loss or absence of the gene's protein product, fragile X mental retardation protein. The phenotype of FXS is consistently associated with heightened anxiety, although no previous study has investigated attentional bias toward threat, a hallmark of anxiety disorders, in individuals with FXS. METHODS: The current study employed a passive-viewing eye-tracking version of the dot probe task to investigate attentional biases toward emotional faces in young children with FXS (n = 47) and without FXS (n = 94)...
September 2017: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
https://www.readbyqxmd.com/read/29340971/denosumab-or-oral-bisphosphonates-in-primary-osteoporosis-a-real-life-study
#12
E Cairoli, S Palmieri, G Goggi, L Roggero, M Arosio, I Chiodini, C Eller-Vainicher
PURPOSE: To compare the response to denosumab (DMAb) therapy with that of oral bisphosphonate (BISPH) treatment in postmenopausal women with primary osteoporosis (PO). METHODS: In this retrospective study, we compared data of 75 PO female patients treated for 24 months with DMab (DMAb Group, age 72.6 ± 8.9 years) with those of 75 PO patients treated with oral bisphosphonates (BISPH Group), matched for age, body mass index, femoral bone mineral density (BMD), prevalent fragility fractures and familiar history of hip fracture...
January 16, 2018: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/29333043/picroside-i-and-picroside-ii-from-tissue-cultures-of-picrorhiza-kurroa
#13
Yamjala Ganeshkumar, Ajmera Ramarao, Ciddi Veeresham
Background: Picrorhiza kurroa (PK) belongs to Scrophulariaceae family and is a representative endemic, medicinal herb, widely distributed throughout the higher altitudes of alpine Himalayas from west to east, between 3000 and 4500 m above mean sea level. Objective: The objective of the present study is to assess the production of picroside I and picroside II from tissue cultures of PK. Materials and Methods: Auxiliary shoot tips of PK were incubated in Murashige and Skoog medium supplemented with indole-3-butyric acid and kinetin phytohormones...
December 2017: Pharmacognosy Research
https://www.readbyqxmd.com/read/29331300/cigarette-smoking-and-hip-volumetric-bone-mineral-density-and-cortical-volume-loss-in-older-adults-the-ages-reykjavik-study
#14
Elisa A Marques, Martine Elbejjani, Vilmundur Gudnason, Gunnar Sigurdsson, Thomas Lang, Sigurdur Sigurdsson, Thor Aspelund, Kristin Siggeirsdottir, Lenore Launer, Gudny Eiriksdottir, Tamara B Harris
This study aimed to explore the relationships of several indicators of cigarette smoking habits (smoking status, pack-years, age at smoking initiation and smoking cessation) with quantitative computed tomographic (QCT)-derived proximal femur bone measures (trabecular vBMD, integral vBMD and the ratio of cortical to total tissue volume (cvol/ivol)) and with subsequent change in these measures over the next five years. A total of 2673 older adults (55.9% women), aged 66-92 years at baseline from the Age, Gene/Environment Susceptibility (AGES)-Reykjavik Study, who had two QCT scans of the hip were studied...
January 10, 2018: Bone
https://www.readbyqxmd.com/read/29329713/baseline-and-pre-operative-1-year-mortality-risk-factors-in-a-cohort-of-509-hip-fracture-patients-consecutively-admitted-to-a-co-managed-orthogeriatric-unit-fonda-cohort
#15
Rocío Menéndez-Colino, Teresa Alarcon, Pilar Gotor, Rocío Queipo, Raquel Ramírez-Martín, Angel Otero, Juan I González-Montalvo
INTRODUCTION: The aim of this study was to determine the patient characteristics that predict 1-year mortality after a hip fracture (HF). METHODS: All patients admitted consecutively with fragility HF during 1 year in a co-managed orthogeriatric unit of a university hospital (FONDA cohort) were assesed. Baseline and admission demographic, clinical, functional, analytical and body-composition variables were collected in the first 72 h after admission. A protocol designed to minimize the consequences of the HF was applied...
January 6, 2018: Injury
https://www.readbyqxmd.com/read/29322222/urinary-pentosidine-levels-negatively-associates-with-trabecular-bone-scores-in-patients-with-type-2-diabetes-mellitus
#16
Y J Choi, S Y Ock, Y Jin, J S Lee, S H Kim, Y -S Chung
Pentosidine levels were higher in diabetic patients with vertebral fractures. Trabecular bone scores were negatively associated with pentosidine levels in diabetic patients only. Our results provide further evidence that AGEs are associated with the pathogenesis of bone fragility in patients with T2DM. INTRODUCTION: Type 2 diabetes mellitus (T2DM) is associated with fracture risk. Pentosidine, an advanced glycation end product (AGE), is associated with prevalent vertebral fractures (VFs) in patients with T2DM...
January 10, 2018: Osteoporosis International
https://www.readbyqxmd.com/read/29314261/future-osteoporotic-fracture-risk-related-to-lumbar-vertebral-trabecular-attenuation-measured-at-routine-body-ct
#17
Scott J Lee, Peter M Graffy, Ryan D Zea, Timothy J Ziemlewicz, Perry J Pickhardt
We sought to determine if vertebral trabecular attenuation values measured on routine body CT scans obtained for a variety of unrelated indications can predict future osteoporotic fractures at multiple skeletal sites. For this HIPAA-compliant and IRB-approved retrospective cohort study, trabecular attenuation of the first lumbar vertebra was measured in 1966 consecutive older adults who underwent chest and/or abdominal CT at a single institution over the course of one year. New pathologic fragility fractures that occurred after a patient's CT study date were identified through an electronic health record database query using ICD-9 codes for vertebral, hip, and extremity fractures...
January 3, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29301284/vitamin-d-status-and-the-relationship-with-bone-fragility-fractures-in-hiv-infected-patients-a-case-control-study
#18
Marco Atteritano, Luigi Mirarchi, Emmanuele Venanzi-Rullo, Domenico Santoro, Chiara Iaria, Antonino Catalano, Antonino Lasco, Vincenzo Arcoraci, Alberto Lo Gullo, Alessandra Bitto, Francesco Squadrito, Antonio Cascio
HIV-infected patients show high risk of fracture. The aims of our study were to determine the prevalence of vertebral fractures (VFs) and their associations with vitamin D in HIV patients. 100 patients with HIV infection and 100 healthy age- and sex-matched controls were studied. Bone mineral density was measured by quantitative ultrasound at the non-dominant heel. Serum osteocalcin and C-terminal telopeptide of collagen type 1 served as bone turnover markers. Bone ultrasound measurements were significantly lower in patients compared with controls (Stiffness Index (SI): 80...
January 2, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29273826/frax-based-intervention-and-assessment-thresholds-in-seven-latin-american-countries
#19
P Clark, E Denova-Gutiérrez, C Zerbini, A Sanchez, O Messina, J J Jaller, C Campusano, C H Orces, G Riera, H Johansson, J A Kanis
Age-specific intervention and assessment thresholds were developed for seven Latin American countries. The intervention threshold ranged from 1.2% (Ecuador) to 27.5% (Argentina) at the age of 50 and 90 years, respectively. In the Latin American countries, FRAX offers a substantial advance for the detection of subjects at high fracture risk. INTRODUCTION: Intervention thresholds are proposed using the Fracture Risk Assessment (FRAX) tool. We recommended their use to calculate the ten-year probability of fragility fracture (FF) in both, men and women with or without the inclusion of bone mineral density (BMD)...
December 23, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/29258874/is-fatty-acid-composition-of-human-bone-marrow-significant-to-bone-health
#20
Ana María Pino, J Pablo Rodríguez
The bone marrow adipose tissue (BMAT) is a conserved component of the marrow microenvironment, providing storage and release of energy and stabilizing the marrow extent. Also, it is recognized both the amount and quality of BMAT are relevant to preserve the functional relationships between BMAT, bone, and blood cell production. In this article we ponder the information supporting the tenet that the quality of BMAT is relevant to bone health. In the human adult the distribution of BMAT is heterogeneous over the entire skeleton, and both BMAT accumulation and bone loss come about with aging in healthy populations...
December 16, 2017: Bone
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