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Fragility index

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https://www.readbyqxmd.com/read/29677054/effects-of-acute-aerobic-exercise-on-arterial-stiffness-and-cerebrovascular-pulsatility-in-adults-with-and-without-hypertension
#1
Wesley K Lefferts, Jacob P DeBlois, Candace N Receno, Tiago V Barreira, Tom D Brutsaert, Robert L Carhart, Kevin S Heffernan
OBJECTIVES: Stiffer central arteries, as seen in hypertension (HTN), foster transmission of pulsatile hemodynamics into fragile cerebral vessels. Aerobic exercise is recommended for adults with HTN, but its effects on arterial stiffness and pulsatility in this group are unclear. This study sought to investigate the effect of acute aerobic exercise on arterial stiffness and cerebrovascular pulsatility in 30 adults with treated HTN and 30 age, sex, and BMI-matched adults without HTN (56 ± 6 years, BMI 28...
April 19, 2018: Journal of Hypertension
https://www.readbyqxmd.com/read/29673324/gabriel-richet-when-medicine-combines-with-courage
#2
EDITORIAL
Pierre Ronco
Gabriel Richet, one of the fathers of the French and international Nephrology, was a man remarkable for his courage, vision and empathy. He was proud and brave, and he presented himself proud of being brave. He opens his interview speaking about his youth, when he was injured, and went back to the fight. He cites the number of stitches he received, but doesn't cite being decorated with the Légion d'Honneur, one of the highest honours of the French Republic. This anecdote perfectly illustrates his elegance and detachment from awards and self-satisfaction...
April 19, 2018: BMC Nephrology
https://www.readbyqxmd.com/read/29667007/failure-in-diagnosis-and-under-treatment-of-osteoporosis-in-elderly-patients-with-fragility-fractures
#3
Sofia Bougioukli, Panagoula Κollia, Theodora Koromila, Sokratis Varitimidis, Michael Hantes, Theofilos Karachalios, Κonstantinos Ν Malizos, Zoe H Dailiana
We evaluated whether osteoporosis is adequately managed and treated in patients suffering from fragility fractures. Factors that influenced osteoporosis diagnosis and treatment rates were also assessed. To this end, patients with the principal diagnosis of low-energy hip, vertebral, or distal radius fractures were recruited for the study. Collected data included risk factors for osteoporosis, history of previous fractures, known history of osteoporosis, and osteoporosis treatment at the time of admission. The patients' prefracture risk profile was also assessed to determine whether osteoporosis could have been identified prior to the index fracture...
April 17, 2018: Journal of Bone and Mineral Metabolism
https://www.readbyqxmd.com/read/29662857/cryohemolysis-erythrocyte-osmotic-fragility-and-supplementary-hematimetric-indices-in-the-diagnosis-of-hereditary-spherocytosis
#4
Ledesma Achem Miryam Emilse, Haro Cecilia, Terán Magdalena María, Mónaco María Eugenia, Issé Blanca Alicia, Sandra Stella Lazarte
Background: Hereditary spherocytosis (HS) is a chronic hemolytic anemia characterized by microspherocytes in the peripheral blood and increased erythrocyte osmotic fragility (EOF). This study evaluated the cryohemolysis test (CHT); initial hemolysis (IH); immediate and incubated hemolysis percentage in 5.5 g/L NaCl (H5.5); mean corpuscular hemoglobin concentration (MCHC); red blood cell distribution width (RDW); and Hb/MCHC, Hb/RDW, and MCHC/RDW ratios for the diagnosis of HS. Methods: Data from 13 patients with HS were evaluated at the Instituto de Bioquímica Aplicada and compared with data from 14 unaffected individuals and 11 patients with anemia due to another etiology...
March 2018: Blood Research
https://www.readbyqxmd.com/read/29661684/trabecular-bone-score-and-hip-structural-analysis-in-patients-with-atypical-femur-fractures
#5
Sanne K C Buitendijk, Denise M van de Laarschot, Alexandra A A Smits, Fjorda Koromani, Fernando Rivadeneira, Thomas J Beck, M Carola Zillikens
Bisphosphonate use has declined dramatically in recent years, partly because of fear of rare side effects like atypical femur fractures (AFFs). It is therefore desirable to have a diagnostic method to identify those at risk of AFF to prevent this serious complication. We compared trabecular microarchitecture and hip geometry between 30 patients with AFF and 141 controls of similar age and sex, using bisphosphonates. Trabecular bone score (TBS) and hip structural analysis (HSA) were used to assess trabecular microarchitecture and macroscopic hip geometry from dual-energy X-ray absorptiometry images of the lumbar spine and hip, respectively...
March 22, 2018: Journal of Clinical Densitometry
https://www.readbyqxmd.com/read/29661411/the-fragility-of-statistically-significant-findings-in-randomised-controlled-anaesthesiology-trials-systematic-review-of-the-medical-literature
#6
REVIEW
G Mazzinari, L Ball, A Serpa Neto, C L Errando, A M Dondorp, L D Bos, M Gama de Abreu, P Pelosi, M J Schultz
The fragility index (FI), the number of events the statistical significance a result depends on, and the number of patients lost to follow-up are important parameters for interpreting randomised clinical trial results. We evaluated these two parameters in randomised controlled trials in anaesthesiology. For this, we performed a systematic search of the medical literature, seeking articles reporting on anaesthesiology trials with a statistically significant difference in the primary outcome and published in the top five general medicine journals, or the top 15 anaesthesiology journals...
May 2018: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/29623400/biomechanical-properties-of-the-patellar-tendon-in-children-with-heritable-connective-tissue-disorders
#7
Jacob K Jensen, Rie H Nygaard, Rene B Svensson, Hanne D Hove, S Peter Magnusson, Michael Kjær, Christian Couppé
PURPOSE: Hereditary connective tissue disorders (HCTDs), such as classic Ehlers-Danlos syndrome (cEDS) and Marfan syndrome (MS) share overlapping features like hypermobility and tissue fragility. In clinical practice it remains a challenge to distinguish children and adolescents with HCTD from healthy children. The purpose of this study was to investigate the biomechanical properties of the patellar tendon and joint laxity (Beighton score) in children with HCTDs (n = 7) compared to healthy controls (n = 14)...
April 5, 2018: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/29613924/assessing-the-risk-benefit-ratio-of-scoliosis-surgery-in-cerebral-palsy-surgery-is-worth-it
#8
Firoz Miyanji, Luigi A Nasto, Paul D Sponseller, Suken A Shah, Amer F Samdani, Baron Lonner, Burt Yaszay, David H Clements, Unni Narayanan, Peter O Newton
BACKGROUND: The true benefits of scoliosis surgery in cerebral palsy (CP) remain uncertain. Our aims were to determine the benefits of spinal fusion according to health-related quality of life (HRQoL) improvement at long-term follow-up and to explore the effect of surgery-related complications on clinical outcomes. METHODS: The cases of consecutive patients who had Gross Motor Function Classification System (GMFCS) level-IV or V cerebral palsy with 5-year follow-up from a prospective, longitudinal, multicenter database were analyzed...
April 4, 2018: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/29604851/interplay-of-intermolecular-interactions-and-flexibility-to-mediate-glass-forming-ability-and-fragility-a-study-of-chemical-analogs
#9
Manoj K Saini, Xiao Jin, Tao Wu, Yingdan Liu, Li-Min Wang
We have investigated the enthalpic and dielectric relaxations of four groups of quinoline analogs having similar structural properties (i.e., rigidity, stiffness, and bulkiness) but a different steric character and the nature of intermolecular interactions and flexibility. The dielectric fragility index (md ) and the enthalpic one (mH ), determined by the Tool-Narayanaswamy-Moynihan-Hodge formalism, are comparable. Generally, for the four sets of molecules of similar structures, both the interactions and flexibility are found to be critical in making the large span of fragility (i...
March 28, 2018: Journal of Chemical Physics
https://www.readbyqxmd.com/read/29581271/l%C3%A3-vy-flight-movements-prevent-extinctions-and-maximize-population-abundances-in-fragile-lotka-volterra-systems
#10
Teodoro Dannemann, Denis Boyer, Octavio Miramontes
Multiple-scale mobility is ubiquitous in nature and has become instrumental for understanding and modeling animal foraging behavior. However, the impact of individual movements on the long-term stability of populations remains largely unexplored. We analyze deterministic and stochastic Lotka-Volterra systems, where mobile predators consume scarce resources (prey) confined in patches. In fragile systems (that is, those unfavorable to species coexistence), the predator species has a maximized abundance and is resilient to degraded prey conditions when individual mobility is multiple scaled...
March 26, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29572869/a-new-approach-to-assess-the-effect-of-photodamage-on-corneocyte-envelope-maturity-using-combined-hydrophobicity-and-mechanical-fragility-assays
#11
D Guneri, R Voegeli, S J Gurgul, M R Munday, A V Rawlings
BACKGROUND: The maturity of the corneocyte envelope (CE) provides information about the barrier functionality of the stratum corneum (SC). Corneocytes are enclosed by the CE, a protein-lipid matrix, contributing to mechanical resistance and hydrophobicity of the SC. OBJECTIVES: The aim of the work was to develop a novel and robust approach to characterize CE maturity based on rigidity, hydrophobicity, and surface area. This offers an alternative approach to the Nile red staining and antigenicity of involucrin to characterise the CE...
March 23, 2018: International Journal of Cosmetic Science
https://www.readbyqxmd.com/read/29572562/autosomal-recessive-osteogenesis-imperfecta-caused-by-a-novel-homozygous-col1a2-mutation
#12
Alice Costantini, Symeon Tournis, Anders Kämpe, Noor Ul Ain, Fulya Taylan, Artemis Doulgeraki, Outi Mäkitie
Osteogenesis imperfecta (OI) is a skeletal dysplasia characterized by brittle bones and extraskeletal manifestations. The disease phenotype varies greatly. Most commonly, OI arises from monoallelic mutations in one of the two genes encoding type I collagen, COL1A1 and COL1A2 and is inherited as an autosomal dominant trait. Here, we describe a consanguineous family with autosomal recessive OI caused by a novel homozygous glycine substitution in COL1A2, NM_000089.3: c.604G>A, p.(Gly202Ser), detected by whole-genome sequencing...
March 23, 2018: Calcified Tissue International
https://www.readbyqxmd.com/read/29572151/fire-resistant-behaviour-of-cellulosic-textile-functionalized-with-wastage-plant-bio-molecules-a-comparative-scientific-report
#13
Santanu Basak, S Wazed Ali
Three different wastage plant based bio-molecules named banana peel powder (Musa acuminata) (BPP), coconut shell (Cocos nucifera) extract (CSE) and pomegranate rind (Punica granatum) extract (PRE) have been explored as fire resistant material on the cellulosic polymer (cotton fabric). To this end, extracts have been applied to the cotton fabric in different concentration at elevated temperature for specific time period. Treated cotton fabric showed 6 (BPP), 8.5 (CSE) and 12 (PRE) times lower vertical burning rate compared to the control cotton fabric...
March 20, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29569390/the-fragility-of-statistically-significant-findings-from-randomized-controlled-trials-in-the-urologic-literature
#14
Vikram M Narayan, Shreyas Gandhi, Kristin Chrouser, Nathan Evaniew, Philipp Dahm
OBJECTIVES: To use the fragility index to evaluate the robustness of statistically significant findings from urological RCTs. MATERIALS AND METHODS: The "fragility index" is defined as the minimum number of patients in one arm of a trial whose status would have to change from "event" to "non-event," such that a statistically significant result becomes non-significant. We identified all RCTs published in 4 major urology journals between 2011-2015, and we determined the fragility index values for those trials reporting statistically significant results of dichotomous outcomes using the Fisher exact test...
March 22, 2018: BJU International
https://www.readbyqxmd.com/read/29564475/increased-rate-of-osteoporosis-low-lean-mass-and-fragility-fractures-in-copd-patients-association-with-disease-severity
#15
R Q Graumam, M M Pinheiro, L E Nery, C H M Castro
A very high rate of osteoporosis, fractures, and low lean mass was observed in patients with chronic obstructive pulmonary disease (COPD). Disease severity was associated with bone and muscle adverse outcomes, while age ≥ 63.5 years old, low lean mass, higher iPTH, and a T-score below - 2.5 were all associated with higher risk of fracture. INTRODUCTION: Osteoporosis is frequently neglected in patients with COPD. We aimed at evaluating the rate of osteoporosis, fractures, and low lean mass in patients with COPD...
March 21, 2018: Osteoporosis International
https://www.readbyqxmd.com/read/29564042/predictors-of-intraoperative-fractures-during-hemiarthroplasty-for-the-treatment-of-fragility-hip-fractures
#16
Nayef Aslam-Pervez, Osman Riaz, Shivkumar Gopal, Fahad Hossain
Background: The aim of our study was to determine the rate and preoperative predictors of intraoperative fracture (IOF) during hip hemiarthroplasty (HA) in patients who have sustained a fragility hip fracture injury. Methods: We reviewed 626 patients who underwent HA at our institution using the National Hip Fracture Database. Various patient- and surgery-related data including demographic information, cement usage, surgeon grade, time to surgery, and operative duration were collected...
March 2018: Clinics in Orthopedic Surgery
https://www.readbyqxmd.com/read/29558352/-malnutrition-and-obesity-among-patients-with-rheumatoid-arthritis-and-chronic-inflammatory-process
#17
Teresa Małecka-Massalska, Aleksandra Majdan
Chronic inflammatory status in patients with rheumatoid arthritis (RA) due to metabolic changes has an effect on body composition. Up to two thirds of patients may be affected by the loss of body cell mass and, thereby, malnutrition including its most severe form - cachexia. Among patients with RA and malnutrition, the total body weight is not reduced and the muscle loss is partially compensated by an increase in body fat. The excess of visceral and trunk adipose tissue is the main factor of increased prevalence of insulin resistance and metabolic syndrome in RA patients...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29543173/widening-viewing-angles-of-automultiscopic-displays-using-refractive-inserts
#18
Geng Lyu, Xukun Shen, Taku Komura, Kartic Subr, Lijun Teng
Displays that can portray environments that are perceivable from multiple views are known as multiscopic displays. Some multiscopic displays enable realistic perception of 3D environments without the need for cumbersome mounts or fragile head-tracking algorithms. These automultiscopic displays carefully control the distribution of emitted light over space, direction (angle) and time so that even a static image displayed can encode parallax across viewing directions (Iightfield). This allows simultaneous observation by multiple viewers, each perceiving 3D from their own (correct) perspective...
April 2018: IEEE Transactions on Visualization and Computer Graphics
https://www.readbyqxmd.com/read/29532733/has-development-assistance-for-health-facilitated-the-rise-of-more-peaceful-societies-in-sub-saharan-africa
#19
Vin Gupta, Alexandre Mason-Sharma, Zoe M Lyon, Endel John Orav, Ashish K Jha, Vanessa B Kerry
Growing evidence suggests that health aid can serve humanitarian and diplomatic ends. This study utilised the Fragile States Index (FSI) for the 47 nations of the World Health Organizations' Africa region for the years 2005-2014 and data on health and non-health development aid spending from the United States (US) for those same years. Absolute amounts of health and non-health aid flows from the US were used as predictors of state fragility. We used time-lagged, fixed-effects multivariable regression modelling with change in FSI as the outcome of interest...
March 13, 2018: Global Public Health
https://www.readbyqxmd.com/read/29524013/monitoring-land-cover-change-and-its-dynamic-mechanism-on-the-qehan-lake-basin-inner-mongolia-north-china-during-1977-2013
#20
Xi Chun, Mei Yong, Jiyao Liu, Wenjun Liang
The Qehan Lake Basin is located in the north of the Otindag Sandy Land, where the fragile eco-environment is sensitive to climate change and human activity. We analyzed land cover change and the concomitant processes of ecological change based on multi-spectral scanning (MSS), thematic mapper (TM), and enhanced TM (ETM+) images. The results showed that from 1977 to 2000, the area of dune sand increased significantly by 840.2 km2 , while the area of high cover grassland (HCGL), medium cover grassland (MCGL), and low cover grassland (LCGL) reduced by 140...
March 9, 2018: Environmental Monitoring and Assessment
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