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Fragility index

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https://www.readbyqxmd.com/read/29038673/thiazides-and-osteoporotic-spinal-fractures-a-suspected-linkage-investigated-by-means-of-a-two-center-case-control-study
#1
Renato De Vecchis, Carmelina Ariano, Giuseppina Di Biase, Michel Noutsias
BACKGROUND: An alleged association of chronic use of thiazide diuretics with an increased risk of bone fragility fractures has been highlighted by a relatively recent prospective cohort study. However, the concept that thiazides exert a beneficial effect on osteoporosis is still a predominant view. This effect would be mediated by the decrease in renal clearance of calcium ions, a pharmacological feature recognized for a long time now to this class of drugs, as opposed to the increase in calcium urinary excretion attributed instead to loop diuretics, i...
November 2017: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/29037877/unbreakable-an-analysis-of-the-fragility-of-randomized-trials-that-support-diabetes-treatment-guidelines
#2
B Chase Kruse, B Matt Vassar
AIMS: To analyze the robustness of randomized controlled trials (RCTs) referenced in the American Diabetes Association's Standards of Medical Care in Diabetes-2017 using the Fragility Index (FI) and Fragility Quotient (FQ). METHODS: We performed a systematic survey of all RCTs referenced in the Standards of Medical Care in Diabetes-2017. One investigator screened for trials and then recorded data from them, including sample size per group, event rate per group, and the dichotomous outcome analyzed by trialists...
October 13, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29020086/violence-insecurity-and-the-risk-of-polio-a-systematic-analysis
#3
Kia Guarino, Arend Voorman, Maxime Gasteen, Donte Stewart, Jay Wenger
BACKGROUND: Since the introduction of polio vaccines in the 1950's and 60's, eradication of poliovirus from the world has been technically feasible. Progress towards this goal, however, has been uneven and influenced by social and political factors that challenge the implementation of robust immunization programs. While violence and insecurity are often cited as barriers to eradication, current global risk models are largely based on virologic and immunologic indicators measured at national levels...
2017: PloS One
https://www.readbyqxmd.com/read/29019551/caries-experience-and-salivary-aspects-in-individuals-with-fragile-x-syndrome
#4
Cristhiane Olívia Ferreira do Amaral, Fabiana Gouveia Straioto, Marcelo Henrique Napimoga, Elizabeth Ferreira Martinez
Fragile X syndrome (FXS) is the most common cause of hereditary mental retardation, but studies on the oral health condition of these patients are rare. The aim of this study was to determine the experience of dental caries in individuals with FXS, by examining the saliva profile, oral hygiene, socioeconomic characteristics and use of controlled drugs in these patients. Dental health was estimated using the decayed, missing and filled teeth index (DMF-T) and sialometry, and the pH value and buffering capacity of the saliva, colony forming units of S...
September 28, 2017: Brazilian Oral Research
https://www.readbyqxmd.com/read/28987093/presence-of-global-and-local-%C3%AE-relaxations-in-an-alkyl-phosphate-glass-former
#5
Tao Wu, Xiao Jin, Manoj K Saini, Ying Dan Liu, K L Ngai, Li-Min Wang
The dynamics of a molecular glass former, tributyl phosphate (TBP), with an alkyl phosphate structure (three alkyl branches emanating from a polar core of PO4) is studied in the supercooled regime by dielectric and thermal (or enthalpic) relaxations. The dielectric fragility index md and the stretching exponent βd of the Kohlrausch-Williams-Watts correlation function are determined. Analyses of the enthalpic relaxation data by the Tool-Narayanaswamy-Moynihan-Hodge formalism yield the enthalpic fragility index mH and stretching exponent βH...
October 7, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28984698/relative-importance-assigned-to-health-care-rationing-principles-at-the-bedside-evidence-from-a-portuguese-and-bulgarian-survey
#6
Micaela Moreira Pinho, Ana Pinto Borges
Activity was undertaken to develop a Prioritization Scoring Index for Portugal and Bulgaria that weights the importance given to ethical rationing principles that should guide decisions at the bedside. Data from two random samples of 355 Portuguese and 298 Bulgarian members of the public were collected from an online questionnaire. Questions asked about the level of importance given to specific issues related to patient's prioritization criteria. Responses were analyzed quantitatively with the SPSS. In the process of selecting the patient to treat, Portuguese and Bulgarian respondents seem unanimous in giving greater importance to (i) the treatment outcomes, (ii) the severity of illness, (iii) children, and (iv) patients' fragility...
October 3, 2017: Health Care Manager
https://www.readbyqxmd.com/read/28974557/utility-of-dxa-screening-for-diagnosis-of-osteoporosis-in-us-veterans-aged-70-years-and-older
#7
Joanna Khatib, Kim Stote, Aidar R Gosmanov
Dual energy X-ray absorptiometry (DXA) is recommended for osteoporosis screening in men aged 70 years and older but supportive data is limited. The aim of this study was to determine the efficacy of DXA for the diagnosis of increased fragility in this group of subjects. We retrospectively identified men aged 70 years and older without prior history of fracture and/or conditions predisposing to low bone mineral density (BMD) who attended the VA endocrinology clinic and performed DXA for osteoporosis screening...
October 2, 2017: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
https://www.readbyqxmd.com/read/28966518/therapeutic-efficacy-of-combination-therapy-using-oral-cyclosporine-with-a-dietary-supplement-pantogar%C3%A2-in-twenty-nail-dystrophy
#8
Su Jin Oh, Jeong Eun Kim, Joo Yeon Ko, Young Suck Ro
BACKGROUND: Twenty-nail dystrophy (TND) is an acquired idiopathic disease characterized by dull, thin, lusterless, and fragile nails with fissuring, small regular pits, and excessive longitudinal ridging. Although various treatment modalities have been performed in order to treat TND, the effects of these treatments are controversial. OBJECTIVE: To evaluate the effectiveness of oral cyclosporine in TND. METHODS: A total of 38 patients with TND were treated with combination therapy using oral cyclosporine with a pantothenic acid complex-based dietary supplement (Pantogar®; Merz Pharmaceuticals GmbH, Germany), whereas 44 patients were treated with the pantothenic acid complex-based dietary supplement alone...
October 2017: Annals of Dermatology
https://www.readbyqxmd.com/read/28955705/heart-rate-variability-more-than-heart-beats
#9
REVIEW
Gernot Ernst
Heart-rate variability (HRV) is frequently introduced as mirroring imbalances within the autonomous nerve system. Many investigations are based on the paradigm that increased sympathetic tone is associated with decreased parasympathetic tone and vice versa. But HRV is probably more than an indicator for probable disturbances in the autonomous system. Some perturbations trigger not reciprocal, but parallel changes of vagal and sympathetic nerve activity. HRV has also been considered as a surrogate parameter of the complex interaction between brain and cardiovascular system...
2017: Frontiers in Public Health
https://www.readbyqxmd.com/read/28929722/-self-perceived-health-status-among-immigrants-in-italy
#10
Alessio Petrelli, Anteo Di Napoli, Alessandra Rossi, Lidia Gargiulo, Concetta Mirisola, Gianfranco Costanzo
OBJECTIVES: to evaluate self-perceived health status of immigrants in Italy. DESIGN: cross-sectional study based on the representative national samples of the multipurpose surveys "Health conditions and use of health services" conducted in 2005 and 2013 by the Italian National Institute of Statistics (Istat). SETTING AND PARTICIPANTS: the study was conducted on the age group of 18-64: No. 80,661 in 2005, among which 3.2% were immigrants, and No...
May 2017: Epidemiologia e Prevenzione
https://www.readbyqxmd.com/read/28927589/molecular-dynamics-of-carrageenan-composites-reinforced-with-cloisite-na-montmorillonite-nanoclay
#11
M J Sanchis, M Carsí, M Culebras, C M Gómez, S Rodriguez, F G Torres
Nanocomposites comprising biodegradable carrageenan and glycerol (KCg) as the host polymer, with different contents of natural montmorillonite (MMT) as filler, were prepared by a solution casting process. Different techniques have been used to determine the interaction/behavior among the different components of the samples such as Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), Transmission electron microscope (TEM) and, mainly, Dielectric relaxation spectroscopy (DRS). FTIR indicates hydrogen interaction between carrageenan matrix and silicate that is confirmed by the XRD data indicating some kind of carrageenan intercalation between the MMT layers...
November 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28899123/subchondral-bone-microarchitecture-analysis-in-the-proximal-tibia-at-7-t-mri
#12
Christoph A Agten, Stephen Honig, Punam K Saha, Ravinder Regatte, Gregory Chang
Background Bone remodels in response to mechanical loads and osteoporosis results from impaired ability of bone to remodel. Bone microarchitecture analysis provides information on bone quality beyond bone mineral density (BMD). Purpose To compare subchondral bone microarchitecture parameters in the medial and lateral tibia plateau in individuals with and without fragility fractures. Material and Methods Twelve female patients (mean age = 58 ± 15 years; six with and six without previous fragility fractures) were examined with dual-energy X-ray absorptiometry (DXA) and 7-T magnetic resonance imaging (MRI) of the proximal tibia...
January 1, 2017: Acta Radiologica
https://www.readbyqxmd.com/read/28890857/how-long-should-the-fully-hillside-closed-forest-protection-be-implemented-on-the-loess-plateau-shaanxi-china
#13
Lin Hou, Sijia Hou
BACKGROUND: Restoration of degraded forest ecosystem is crucial for regional sustainable development. To protect the country's fragile and fragmented environment, the Chinese government initiated an ecological engineering project, the Natural Forest Protection Program, in seventeen provinces in China beginning in 1998. Fully hillside-closed forest protection (vegetation restoration naturally without any artificial disturbance) was one of vital measures of the Natural Forest Protection Program applied nation wide...
2017: PeerJ
https://www.readbyqxmd.com/read/28874773/cortical-and-trabecular-morphology-is-altered-in-the-limb-bones-of-mice-artificially-selected-for-faster-skeletal-growth
#14
Saira Farooq, Shannon Leussink, Leah M Sparrow, Marta Marchini, Hayley M Britz, Sarah L Manske, Campbell Rolian
Bone strength is influenced by mineral density and macro- and microstructure. Research into factors that contribute to bone morphology and strength has focused on genetic, environmental and morphological factors (e.g., body mass index), but little is known regarding the impact of rates of skeletal elongation on adult skeletal morphology and strength. Using micro-CT, we examined the impact of rates of skeletal elongation on bone cortical and trabecular morphology, and on rates of estrogen-dependent bone loss in the tibia in CD-1 mice, and in mice with accelerated skeletal growth (Longshanks)...
September 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28869637/evaluation-of-functional-and-structural-changes-affecting-the-lumbar-spine-in-professional-field-hockey-players
#15
Małgorzata Barbara Ogurkowska, Krzysztof Kawałek
PURPOSE: The aim of this study was to evaluate functional and structural changes in the lumbar spine which occurred as a consequence of playing field hockey. METHODS: The research group consisted of 20 male professional field hockey players. Computed tomography scans were collected to define the radiological density of the vertebral bodies and to calculate Young's modulus. An electrogoniometer was used to measure the range of movement. Geometric parameters, such as Lumbar Lordosis Angle, Index of Lumbar Lordosis, Whitmann-Ferguson Angle and Anterior Pelvic Tilt, were also measured...
2017: Acta of Bioengineering and Biomechanics
https://www.readbyqxmd.com/read/28856552/behavioral-markers-of-emergent-stranger-anxiety-in-infants-and-toddlers-with-fragile-x-syndrome
#16
Bridgette Tonnsen, Jessica Scherr, Debra Reisinger, Jane Roberts
Studying anxiety in neurogenetic syndromes may inform the intersection of biological and developmental risks, facilitating effective and targeted interventions. We longitudinally examined stranger fear in infants and toddlers with fragile X syndrome (FXS; n = 46) and typical controls (n = 33), as well as associations between observed stranger fear and rating scales of anxiety, withdrawal and autism features within FXS. Results indicated atypical facial fear in FXS, although facial fear did not index anxiety, autistic symptoms or social withdrawal...
August 30, 2017: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/28854917/combination-of-measures-of-handgrip-strength-and-red-cell-distribution-width-can-predict-in-hospital-complications-better-than-the-asa-grade-after-hip-fracture-surgery-in-the-elderly
#17
Hyung-Min Ji, Jun Han, Hi-Won Bae, Ye-Yeon Won
BACKGROUND: Early detection of a high-risk patient following hip fracture surgery is of paramount clinical importance. American Society of Anesthesiologists (ASA) grading is an easy and efficient index in predicting a worse outcome. The red cell distribution width (RDW) and handgrip strength, are gaining interest as a prediction tool as well. Accordingly, the objective of this study was to investigate the potential association between ASA, RDW and grip strength and detect the effects of combining RDW and grip strength for predicting early complication after hip fracture surgery in the elderly...
August 30, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28851521/incidence-of-bone-protection-and-associated-fragility-injuries-in-patients-with-proximal-femur-fractures
#18
Ignacio Aguado-Maestro, Michalis Panteli, Manuel García-Alonso, Alejandro Bañuelos-Díaz, Peter V Giannoudis
OBJECTIVES: Our aim was to investigate whether patients presenting with fragility fractures of the proximal femur are receiving osteoporosis treatment and to assess the number of other fragility fractures they have sustained prior to admission. METHODS: All patients presenting to our institution with fragility fractures of the proximal femur within an 18-month period (January 2012-August 2013) were included. Patient demographics; fracture classification (AO/OTA); American Society of Anesthesiologists (ASA) grade; Abbreviated Mental Test Score (AMTS) on admission; type of operation; time to operation; peri-operative complications; length of hospital stay (LOS); walking status; osteoporotic medication; Dual-energy X-ray absorptiometry (DEXA) results; additional fragility fractures; and mortality were collected and analysed...
August 26, 2017: Injury
https://www.readbyqxmd.com/read/28842782/optimal-post-operative-radiation-after-soft-tissue-sarcoma-resection-is-achieved-in-less-than-two-thirds-of-cases
#19
Laurent Casabianca, Sarah Kreps, Sylvie Helfre, Martin Housset, Philippe Anract, David J Biau
PURPOSE: Local control of soft tissue sarcomas frequently involves adjuvant radiation to the surgical resection. When opting for post-operative radiation, care should be taken that radiation is started within some reasonable time after the surgery. We were interested to the proportion of patients who did not recieve optimal post-operative radiation and the variables associated. METHODS: We retrospectively analyzed a series of 77 patients operated on for an extremity soft-tissue sarcoma and due for post-operative radiotherapy...
August 25, 2017: International Orthopaedics
https://www.readbyqxmd.com/read/28842728/discrepancy-between-bone-density-and-bone-material-strength-index-in-three-siblings-with-camurati-engelmann-disease
#20
S Herrera, R Soriano, X Nogués, R Güerri-Fernandez, D Grinberg, N García-Giralt, N Martínez-Gil, S Castejón, A González-Lizarán, S Balcells, A Diez-Perez
Camurati-Engelmann (CE) is a very rare disease affecting one in every million persons worldwide. It is characterized by an enlargement of long bones. We aimed to assess bone characteristics in three siblings with different tools. Even if there was an excess of bone density, quality seemed to be deteriorated. INTRODUCTION: CE disease is a rare monogenic disorder affecting approximately one in every million persons worldwide. It is mainly characterized by a progressive hyperostosis of the periosteum and endosteum of the diaphysis of long bones...
August 25, 2017: Osteoporosis International
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