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https://www.readbyqxmd.com/read/29900159/is-sarcopenia-a-potential-risk-factor-for-distal-radius-fracture-analysis-using-propensity-score-matching
#1
Jun-Ku Lee, Byung-Ho Yoon, Chi Hoon Oh, Jung Gon Kim, Soo-Hong Han
Background: Cases of low-energy-induced distal radius fracture (DRF) are increasing. Sarcopenia is considered to be an independent risk factor for fragility fractures. We compared body appendicular lean muscle mass (ALM) and bone mineral density (BMD) in patients with DRF and a comparable control population. This study aimed to investigate the correlation between skeletal muscle mass and DRF. Methods: We performed a retrospective review of patients diagnosed with fragility DRF...
May 2018: Journal of Bone Metabolism
https://www.readbyqxmd.com/read/29883332/-malnutrition-and-obesity-among-patients-with-rheumatoid-arthritis-and-chronic-inflammatory-process
#2
Teresa Małecka-Massalska, Aleksandra Majdan
Chronic inflammatory status in patients with rheumatoid arthritis (RA) due to metabolic changes has an effect on body composition. Up to two thirds of patients may be affected by the loss of body cell mass and, thereby, malnutrition including its most severe form - cachexia. Among patients with RA and malnutrition, the total body weight is not reduced and the muscle loss is partially compensated by an increase in body fat. The excess of visceral and trunk adipose tissue is the main factor of increased prevalence of insulin resistance and metabolic syndrome in RA patients...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29860666/long-term-effects-of-functional-impairment-on-fracture-risk-and-mortality-in-postmenopausal-women
#3
T Rikkonen, K Poole, J Sirola, R Sund, R Honkanen, H Kröger
Our findings imply that simple functional tests can predict both hip fracture risk and excess mortality in postmenopausal women. Since the tests characterize general functional capacity (one-legged stance, squatting down, and grip strength), these simple measures should have clinical utility in the assessment of women at risk of falls and fragility fracture. INTRODUCTION: Functional impairment is associated with the risk of fall, which is the leading cause of hip fracture. We aimed to determine how clinical assessments of functional impairment predict long-term hip fracture and mortality...
June 2, 2018: Osteoporosis International
https://www.readbyqxmd.com/read/29860664/real-world-antidiabetic-drug-use-and-fracture-risk-in-12-277-patients-with-type-2-diabetes-mellitus-a-nested-case-control-study
#4
E Losada, B Soldevila, M S Ali, D Martínez-Laguna, X Nogués, M Puig-Domingo, A Díez-Pérez, D Mauricio, D Prieto-Alhambra
We conducted a nested case-control study to study the association between antidiabetic treatments (alone or in combination) use and fracture risk among incident type 2 Diabetes mellitus patients. We found an increased risk of bone fracture with insulin therapy compared to metformin monotherapy. INTRODUCTION: Patients with type 2 diabetes mellitus (T2DM) have an increased risk of fragility fractures, to which antidiabetic therapies may contribute. We aimed to characterize the risk of fracture associated with different antidiabetic treatments as usually prescribed to T2DM patients in actual practice conditions...
June 2, 2018: Osteoporosis International
https://www.readbyqxmd.com/read/29797895/-modis-driven-estimation-of-regional-evapotranspiration-in-karst-area-of-southwest-china-based-on-the-penman-monteith-leuning-algorithm
#5
Hao Zhe Zhong, Xian Li Xu, Rong Fei Zhang, Mei Xian Liu
Karst area in southwestern China is characterized with complex topography, low soil water capacity, and fragile ecosystem. Accurate estimation of regional evapotranspiration is essential for ecological restoration and water resources management in southwestern China. Based on observed evapotranspiration and meteorological data, this study aimed to estimate spatial upscale evapotranspiration using the MOD15A2 LAI and Penman-Monteith-Leuning (PML) model, within which the stomatal conductance and soil wetness index were optimized by the least-square method...
May 2018: Ying Yong Sheng Tai Xue Bao, the Journal of Applied Ecology
https://www.readbyqxmd.com/read/29795053/adherence-to-the-recommended-prevention-strategies-before-and-after-a-hip-fragility-fracture-what-makes-us-go-blind
#6
Alexandra Daniel, Mary Lucy Marques, Luísa Brites, Carolina Torres, Andréa Marques, José António Pereira da Silva
OBJECTIVES: Our main objective was to evaluate the percentage of patients under anti-osteoporotic treatment (OT) at the time of hip fracture (HF) and one and four years after the HF event. We compared these results with the percentage of patients who should be under treatment at all three stages, according to the recently published Portuguese cost-effectiveness recommendations (PCER) for OT. Data regarding occurrence of new fragility fractures and mortality were also determined, one and four years after the HF event...
May 24, 2018: Acta Reumatológica Portuguesa
https://www.readbyqxmd.com/read/29783670/adult-premenopausal-bone-health-related-to-reproductive-characteristics-population-based-data-from-the-canadian-multicentre-osteoporosis-study-cam-os
#7
Azita Goshtasebi, Claudie Berger, Susan I Barr, Christopher S Kovacs, Tanveer Towheed, K Shawn Davison, Jerilynn C Prior
Amenorrhea is important for women's bone health. However, few have reported reproductive, anthropometric (body mass index [BMI], height) and bone health (areal bone mineral density [BMD], prevalent fractures) in a population-based study. The purposes of this cross-sectional study of women in the randomly-selected Canadian Multicentre Osteoporosis Study (CaM os ) population were: (1) to describe reproductive, demographic, anthropometric and lifestyle variables; and (2) in menstruating women, to relate reproductive and other variables to BMD at the lumbar spine (L1-4, LS), femoral neck (FN) and total hip (TH) sites and to prevalent fragility fractures...
May 18, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29776756/sex-hormone-binding-globulin-is-a-biomarker-associated-with-nonvertebral-fracture-in-men-on-dialysis-therapy
#8
Jasna Aleksova, Phillip Wong, Robert McLachlan, Kay Weng Choy, Peter R Ebeling, Frances Milat, Grahame J Elder
Gonadal hormones impact bone health and higher values of sex hormone-binding globulin (SHBG) have been independently associated with fracture risk in men without chronic kidney disease. People with chronic kidney disease have a greatly increased fracture risk, and gonadal dysfunction is common in men receiving dialysis treatment. Nevertheless, in these men the effect of gonadal steroids and SHBG on bone mineral density (BMD) and fracture risk is unknown. Here we investigate relationships between gonadal steroids, SHBG, BMD and fracture in men on long-term dialysis therapy, awaiting kidney or simultaneous pancreas kidney transplantation...
May 15, 2018: Kidney International
https://www.readbyqxmd.com/read/29769605/sex-difference-in-bone-architecture-and-bone-fragility-in-vietnamese
#9
Lan T Ho-Pham, Thao P Ho-Le, Linh D Mai, Tam M Do, Minh C Doan, Tuan V Nguyen
This study sought to define the sex-difference in trabecular and cortical bone parameters in Vietnamese individuals. The study involved 1404 women and 864 men aged between 20 and 86 years who were recruited from Ho Chi Minh City, Vietnam. Trabecular and cortical volumetric BMD were measured at the proximal tibia and proximal radius at 4%, 38%, and 66% points, using a peripheral quantitative computed tomography XCT2000 (Stratec, Germany). Polar strength strain index was estimated from cortical bone parameters...
May 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29766482/-fragile-x-syndrome-new-therapeutic-strategies
#10
S Zeidler, B Dierckx, K Lubbers, A M van Eeghen, C R Lincke, J A Kievit, R Willemsen, A Rietman
Fragile X syndrome (fxs) is the most common hereditary cause of intellectual disability and autism spectrum disorders. Targeted treatment is currently lacking. In the past decades an enormous amount of knowledge has been obtained concerning the involved molecular pathways, introducing potential targets for disease modifying therapy.<br/> AIM: To present an overview of the development of targeted treatment for fxs.<br/> METHOD: Several important publications were collected and indexed.<br/> RESULTS: While preclinical animal model studies with targeted interventions are promising, the translation to the clinic has been disappointing...
2018: Tijdschrift Voor Psychiatrie
https://www.readbyqxmd.com/read/29760963/effectiveness-of-a-day-rehabilitation-program-in-improving-functional-outcome-and-reducing-mortality-and-readmission-of-elderly-patients-with-fragility-hip-fractures
#11
Tak Man Wong, Frankie K L Leung, Tak Wing Lau, Christian Fang, Felix H W Chan, Jun Wu
Introduction: The incidence of hip fracture is projected to increase in the next 25 years as the world population ages. Hip fracture is often associated with subsequent readmission and mortality. Nevertheless, elderly patients often may not achieve the same level of functional ability as prior to their injury. Several studies have shown that close collaboration between orthopedic surgeons and geriatricians can improve such outcomes and Geriatric Day Hospital (GDH) is one of the examples of collaboration to improve such outcomes...
2018: Geriatric Orthopaedic Surgery & Rehabilitation
https://www.readbyqxmd.com/read/29754981/dialysis-patients-undergoing-total-knee-arthroplasty-have-significantly-increased-odds-of-perioperative-adverse-events-independent-of-demographic-and-comorbidity-factors
#12
Taylor D Ottesen, Cheryl K Zogg, Monique S Haynes, Rohil Malpani, Kirthi S Bellamkonda, Jonathan N Grauer
BACKGROUND: The prevalence of dialysis-dependent patients is growing, and an increasing number of these patients are being considered for total knee arthroplasty (TKA). Studies assessing the preoperative risk associated with TKA in this population are limited to institutional cohorts with small sample sizes or national inpatient databases that lack follow-up data. METHODS: The 2006-2015 National Surgical Quality Improvement Program databases were queried for adult patients undergoing elective TKA...
April 19, 2018: Journal of Arthroplasty
https://www.readbyqxmd.com/read/29730983/the-challenge-of-aging-and-pharmacoterapeutic-complexity-in-the-hiv-patient
#13
Ramón Morillo-Verdugo, José Ramón Blanco Ramos, Laila Abdel-Kader Martín, María Álvarez de Sotomayor
OBJECTIVE: To describe the current knowledge and management of aging and  pharmacotherapeutic complexity in HIV + patients. METHOD: A review of literature was carried out, including articles, originals or  reviews, published in English or Spanish, from 2007 to 2017, which analysed the aging and pharmacotherapeutic complexity in HIV + patients. The terms  «Polypharmacy»/»Polypharmacy», «Aging»/»Aging», «Frailty»/»Fragility»,  «Pharmacotherapeutic Complexity»/»Medication Regimen Complexity» and  «HIV»/"HIV» were combined...
May 1, 2018: Farmacia Hospitalaria
https://www.readbyqxmd.com/read/29727737/morbidity-and-mortality-after-fragility-hip-fracture-surgery-in-patients-receiving-vitamin-k-antagonists-and-direct-oral-anticoagulants
#14
Tal Frenkel Rutenberg, Steven Velkes, Maria Vitenberg, Avi Leader, Yael Halavy, Pia Raanani, Mustafa Yassin, Galia Spectre
INTRODUCTION: Early surgical treatment is recommended to reduce morbidity and mortality in patients with fragility hip fractures. Anticoagulation treatment poses a surgical challenge. While the action of vitamin K antagonists (VKAs) can be reversed, for direct oral anticoagulants (DOACs) antidote is only available for dabigatran. We aimed to assess the outcomes of patients treated with VKAs or DOACs undergoing surgical treatment for fragility hip fractures. MATERIALS AND METHODS: A retrospective study of patients presenting with proximal femoral fractures between January 2012 and June 2016...
June 2018: Thrombosis Research
https://www.readbyqxmd.com/read/29721240/mexican-patients-with-hiv-have-a-high-prevalence-of-vertebral-fractures
#15
José Antonio Mata-Marín, Carla I Arroyo-Anduiza, María de Los Ángeles Berrospe-Silva, Alberto Chaparro-Sánchez, Ana Gil-Avila, Jesús Gaytán-Martínez
Low bone mineral density (BMD) and fragility fractures are common in individuals infected with HIV, who are undergoing antiretroviral therapy (ART). In high-income countries, dual energy X-ray absorptiometrry is typically used to evaluate osteopenia or osteoporosis in HIV infected individuals. However, this technology is unavailable in low andmiddle income countries, so a different approach is needed. The aim of this study was to use X-ray scans of the spine to determine the prevalence of and associated risk factors for vertebral fractures in HIVinfected patients in a tertiary-care hospital in Mexico...
March 29, 2018: Infectious Disease Reports
https://www.readbyqxmd.com/read/29719664/indigestible-neutral-detergent-fibers-relationship-between-forage-fragility-and-neutral-detergent-fibers-digestibility-in-total-mixed-ration-and-some-feedstuffs-in-dairy-cattle
#16
Mostafa Soufizadeh, Rasoul Pirmohammadi, Yunes Alijoo, Hamed Khalilvandi Behroozyar
Indigestible neutral detergent fibers (iNDF) accurately predict forage digestibility when measured in situ . The objective of this study was to determine the effects of rumen incubation times on the estimated concentrations of iNDF for four forages (alfalfa hay, corn silage, wheat straw and orchard grass), four concentrates (barley grain, soybean meal, beet pulp and wheat bran) and two total mixed ration samples in dairy cows. The iNDF contents of the samples were evaluated in 10 feeds using three ruminally cannulated Holstein cows in a completely randomized design...
2018: Veterinary Research Forum
https://www.readbyqxmd.com/read/29710580/development-and-validation-of-an-environmental-fragility-index-efi-for-the-neotropical-savannah-biome
#17
Diego R Macedo, Robert M Hughes, Philip R Kaufmann, Marcos Callisto
Augmented production and transport of fine sediments resulting from increased human activities are major threats to freshwater ecosystems, including reservoirs and their ecosystem services. To support large scale assessment of the likelihood of soil erosion and reservoir sedimentation, we developed and validated an environmental fragility index (EFI) for the Brazilian neotropical savannah. The EFI was derived from measured geoclimatic controls on sediment production (rainfall, variation of elevation and slope, geology) and anthropogenic pressures (natural cover, road density, distance from roads and urban centers) in 111 catchments upstream of four large hydroelectric reservoirs...
April 23, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29687967/vertebral-compression-fractures-associated-with-yoga-a-case-series
#18
Jad G Sfeir, Matthew T Drake, Vikram J Sonawane, Mehrsheed Sinaki
BACKGROUND: The importance of exercise in skeletal health is increasingly recognized by both patients and providers. However, the safety of prescribed or recreational exercise in at-risk populations remains under-reported and under-publicized. Yoga has gained widespread popularity due to its physical and psychological benefits. When practiced in a population at increased fracture risk, however, some yoga poses may increase fracture risk, particularly at the spine, rather than increasing BMD as noted in recent popular press reports...
April 24, 2018: European Journal of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/29683494/the-fragility-of-statistically-significant-findings-from-randomized-trials-in-head-and-neck-surgery
#19
Christopher W Noel, Caitlin McMullen, Christopher Yao, Eric Monteiro, David P Goldstein, Antoine Eskander, John R de Almeida
OBJECTIVES: The Fragility Index (FI) is a novel tool for evaluating the robustness of statistically significant findings in a randomized control trial (RCT). It measures the number of events upon which statistical significance depends. We sought to calculate the FI scores for RCTs in the head and neck cancer literature where surgery was a primary intervention. DATA SOURCES: Potential articles were identified in PubMed (MEDLINE), Embase, and Cochrane without publication date restrictions...
April 23, 2018: Laryngoscope
https://www.readbyqxmd.com/read/29682316/physical-properties-of-the-tunic-in-the-pinkish-brown-salp-pegea-confoederata-tunicata-thaliacea
#20
Daisuke Sakai, Hiroshi Kakiuchida, Jun Nishikawa, Euichi Hirose
Background: Invisibility in the water column is a crucial strategy for gelatinous zooplanktons in avoiding detection by visual predators, especially for animals distributed in the euphotic zone during the daytime; i.e., surface dwellers that do not undergo diel vertical migration. Salps, a member of the subphylum Tunicata (Urochordata), usually have a transparent body that is entirely covered with a cellulosic matrix, called the tunic. Some non-migrator species are known to exhibit a nano-scale nipple array on the tunic surface...
2018: Zoological Letters
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