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https://www.readbyqxmd.com/read/29349601/prospective-feasibility-analysis-of-a%C3%A2-novel-off-line-approach-for-mr-guided-radiotherapy
#1
Tilman Bostel, Asja Pfaffenberger, Stefan Delorme, Constantin Dreher, Gernot Echner, Peter Haering, Clemens Lang, Mona Splinter, Frederik Laun, Marco Müller, Oliver Jäkel, Jürgen Debus, Peter E Huber, Florian Sterzing, Nils H Nicolay
BACKGROUND: The present work aimed to analyze the feasibility of a shuttle-based MRI-guided radiation therapy (MRgRT) in the treatment of pelvic malignancies. PATIENTS AND METHODS: 20 patients with pelvic malignancies were included in this prospective feasibility analysis. Patients underwent daily MRI in treatment position prior to radiotherapy at the German Cancer Research Center. Positional inaccuracies, time and patient compliance were assessed for the application of off-line MRgRT...
January 18, 2018: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/29346106/spatial-position-measurement-system-for-surgical-navigation-using-3-d-image-marker-based-tracking-tools-with-compact-volume
#2
Zhencheng Fan, Guowen Chen, Junchen Wang, Hongen Liao
We develop a spatial position measurement system using three-dimensional (3-D) image marker-based tracking tools targeted at surgical navigation in minimally invasive surgery. We generate 3-D image markers with spatial information encoded to 2-D images, design tracking tools with the 3-D image markers, and analyze the tracking tools' theoretical spatial errors, which are primarily limited by the spatial distribution of reconstructed fiducial 3-D markers. A pattern analysis-based positional measurement algorithm is developed to calculate the tool's spatial information using its spatial configuration...
February 2018: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/29345604/a-new-approach-of-three-dimensional-guidance-in-paediatric-cath-lab-segmented-and-tessellated-heart-models-for-cardiovascular-interventions-in-chd
#3
Nicole Ehret, Muhannad Alkassar, Sven Dittrich, Robert Cesnjevar, André Rüffer, Michael Uder, Oliver Rompel, Matthias Hammon, Martin Glöckler
BACKGROUND: Optimal imaging is essential for catheter-based interventions in CHD. The three-dimensional models in volume-rendering technique currently in use are not standardised. This paper investigates the feasibility and impact of novel three-dimensional guidance with segmented and tessellated three-dimensional heart models in catheterisation of CHD. In addition, a nearly radiation-free two- to three-dimensional registration and a biplane overlay were used. Methods and results We analysed 60 consecutive cases in which segmented tessellated three-dimensional heart models were merged with live fluoroscopy images and aligned using the tracheal bifurcation as a fiducial mark...
January 18, 2018: Cardiology in the Young
https://www.readbyqxmd.com/read/29340290/tailoring-four-dimensional-cone-beam-ct-acquisition-settings-for-fiducial-marker-based-image-guidance-in-radiation-therapy
#4
Peng Jin, Niek van Wieringen, Maarten C C M Hulshof, Arjan Bel, Tanja Alderliesten
Use of four-dimensional cone-beam CT (4D-CBCT) and fiducial markers for image guidance during radiation therapy (RT) of mobile tumors is challenging due to the trade-off among image quality, imaging dose, and scanning time. This study aimed to investigate different 4D-CBCT acquisition settings for good visibility of fiducial markers in 4D-CBCT. Using these 4D-CBCTs, the feasibility of marker-based 4D registration for RT setup verification and manual respiration-induced motion quantification was investigated...
April 2018: Journal of Medical Imaging
https://www.readbyqxmd.com/read/29338305/safety-and-feasibility-of-prostate-stereotactic-ablative-radiotherapy-using-multi-modality-imaging-and-flattening-filter-free
#5
Aileen Duffton, Azmat Sadozye, Lynsey Devlin, Nicholas MacLeod, Carolynn Lamb, Suzanne Smith, Philip McLoone, Muthu Sankaralingam, John Foster, Stephanie Paterson, Stefanie Keatings, David Dodds
PURPOSE: To investigate feasibility and safety of SABR in the management of prostate cancer while employing MR/CT fusion for delineation, fiducial markers seeds for positioning and Varian Rapidarc with FFF delivery. METHODS: Forty-one patients were treated for low-intermediate risk prostate cancer with initial PSA (iPSA) of ≤20ng/ml, Gleason score 6-7. Patients had MR/CT fusion for delineation of prostate +/-seminal vesicles. CT/MR fusion images were used for delineation and planned using flattening filter free modality...
January 17, 2018: British Journal of Radiology
https://www.readbyqxmd.com/read/29329997/clinical-log-data-analysis-for-assessing-the-accuracy-of-the-cyberknife-fiducial-free-lung-tumor-tracking-system
#6
Masao Nakayama, Hideki Nishimura, Hiroshi Mayahara, Masaki Nakamura, Kazuyuki Uehara, Shinji Tsudou, Aya Harada, Hiroaki Akasaka, Ryohei Sasaki
PURPOSE: The CyberKnife Xsight Lung Tracking (XLT) and 1-View tracking systems can synchronize beam targeting to a visible lung tumor with respiratory motion during irradiation without requiring internal fiducial markers. The systems use a correlation model that relates external marker positions to tumor positions as well as a prediction model that predicts the target's future position. In this study, the correlation and prediction model uncertainties related to the CyberKnife fiducial-free tumor tracking system were evaluated using clinical log data...
November 4, 2017: Practical Radiation Oncology
https://www.readbyqxmd.com/read/29323372/highly-stable-lipid-encapsulation-of-fluorescent-nanodiamonds-for-bioimaging-applications
#7
Shingo Sotoma, Feng-Jen Hsieh, Yen-Wei Chen, Pei-Chang Tsai, Huan-Cheng Chang
Highly stable lipid-encapsulated fluorescent nanodiamonds (FNDs) are produced by photo-crosslinking of diacetylene-containing lipids physically attached to the FND surface. Not only is this coating method simple and fast, but also it gives the FND-lipid hybrids favorable properties for bioapplications. The hybrids are useful as fluorescent biolabels as well as fiducial markers for correlative light and electron microscopy.
January 11, 2018: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/29317629/3d-single-molecule-super-resolution-microscopy-with-a-tilted-light-sheet
#8
Anna-Karin Gustavsson, Petar N Petrov, Maurice Y Lee, Yoav Shechtman, W E Moerner
Tilted light sheet microscopy with 3D point spread functions (TILT3D) combines a novel, tilted light sheet illumination strategy with long axial range point spread functions (PSFs) for low-background, 3D super-localization of single molecules as well as 3D super-resolution imaging in thick cells. Because the axial positions of the single emitters are encoded in the shape of each single-molecule image rather than in the position or thickness of the light sheet, the light sheet need not be extremely thin. TILT3D is built upon a standard inverted microscope and has minimal custom parts...
January 9, 2018: Nature Communications
https://www.readbyqxmd.com/read/29297208/method-for-accurate-registration-of-tissue-autofluorescence-imaging-data-with-corresponding-histology-a-means-for-enhanced-tumor-margin-assessment
#9
Jakob Unger, Tianchen Sun, Yi-Ling Chen, Jennifer E Phipps, Richard J Bold, Morgan A Darrow, Kwan-Liu Ma, Laura Marcu
An important step in establishing the diagnostic potential for emerging optical imaging techniques is accurate registration between imaging data and the corresponding tissue histopathology typically used as gold standard in clinical diagnostics. We present a method to precisely register data acquired with a point-scanning spectroscopic imaging technique from fresh surgical tissue specimen blocks with corresponding histological sections. Using a visible aiming beam to augment point-scanning multispectral time-resolved fluorescence spectroscopy on video images, we evaluate two different markers for the registration with histology: fiducial markers using a 405-nm CW laser and the tissue block's outer shape characteristics...
January 2018: Journal of Biomedical Optics
https://www.readbyqxmd.com/read/29285686/novel-real-time-tumor-contouring-method-using-deep-learning-to-prevent-mistracking-in-x-ray-fluoroscopy
#10
Toshiyuki Terunuma, Aoi Tokui, Takeji Sakae
Robustness to obstacles is the most important factor necessary to achieve accurate tumor tracking without fiducial markers. Some high-density structures, such as bone, are enhanced on X-ray fluoroscopic images, which cause tumor mistracking. Tumor tracking should be performed by controlling "importance recognition": the understanding that soft-tissue is an important tracking feature and bone structure is unimportant. We propose a new real-time tumor-contouring method that uses deep learning with importance recognition control...
December 28, 2017: Radiological Physics and Technology
https://www.readbyqxmd.com/read/29279195/minimizing-fiducial-localization-error-using-sphere-based-registration-in-jaw-tracking
#11
Amir H Abdi, Alan G Hannam, Ian K Stavness, Sidney Fels
Some of the jaw tracking methods may be limited in terms of their accuracy or clinical applicability. This article introduces the sphere-based registration method to minimize the fiducial (reference landmark) localization error (FLE) in tracking and coregistration of physical and virtual dental models, to enable an effective clinical analysis of the patient's masticatory functions. In this method, spheres (registration fiducials) are placed on the corresponding polygonal concavities of the physical and virtual dental models based on the geometrical principle that establishes a unique spatial position for a sphere inside an infinite trihedron...
December 15, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/29273204/locking-the-elbow-improved-antibody-fab-fragments-as-chaperones-for-structure-determination
#12
Lucas J Bailey, Kimberly M Sheehy, Pawel K Dominik, Vinson Liang, Huan Rui, Michael Clark, Mateusz Jaskolowski, Yejoon Kim, Dawid Deneka, Wei-Jen Tang, Anthony A Kossiakoff
Antibody Fab fragments have been exploited with significant success to facilitate the structure determination of challenging macromolecules as crystallization chaperones and as molecular fiducial marks for single particle cryo-EM approaches. However, the inherent flexibility of the "elbow" regions, which link the constant and variable domains of the Fab can introduce disorder and thus, diminish their effectiveness. We have developed a phage display engineering strategy to generate synthetic Fab variants that significantly reduces elbow flexibility, while maintaining their high affinity and stability...
December 19, 2017: Journal of Molecular Biology
https://www.readbyqxmd.com/read/29258694/systematic-intrafraction-shifts-of-mediastinal-lymph-node-targets-between-setup-imaging-and-radiation-treatment-delivery-in-lung-cancer-patients
#13
Mai Lykkegaard Schmidt, Lone Hoffmann, Ditte S Møller, Marianne Marquard Knap, Torben Riis Rasmussen, Birgitte Holst Folkersen, Per Rugaard Poulsen
BACKGROUND AND PURPOSE: Internal target motion results in geometrical uncertainties in lung cancer radiotherapy. In this study, we determined the intrafraction motion and baseline shifts of mediastinal lymph node (LN) targets between setup imaging and treatment delivery. MATERIAL AND METHODS: Ten lung cancer patients with 2-4 fiducial markers implanted in LN targets received intensity-modulated radiotherapy with a daily setup cone-beam CT (CBCT) scan used for online soft-tissue match on the primary tumor...
December 16, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29250970/-image-guided-radiotherapy-for-muscle-invasive-bladder-cancer-with-intravesical-lipiodol-injection-a-new-option-for-bladder-sparing-treatment
#14
Jorgo Kliton, Csaba Polgár, Péter Tenke, Gábor Kovács, Tibor Major, Gábor Stelczer, Péter Ágoston
INTRODUCTION AND AIM: To implement lipiodol as a fiducial marker of the tumor bed for image-guided radiotherapy with simultaneous integrated boost technique as part of radiochemotherapy for muscle invasive bladder tumors. METHOD: Since April 2016, radiochemotherapy was performed in 3 male patients with muscle invasive, transitional cell bladder carcinoma. Prior to radiochemotherapy, tumor bed resection was performed for each patient, at the same time 10 ml of lipiodol solution was injected submucosally into the resection site, thus marking the tumor bed for escalated dose irradiation...
December 2017: Orvosi Hetilap
https://www.readbyqxmd.com/read/29243669/simultaneous-tumor-and-surrogate-motion-tracking-with-dynamic-mri-for-radiation-therapy-planning
#15
Seyoun Park, Rana Farah, Steven M Shea, Erik J Tryggestad, Russell Hales, Junghoon Lee
Respiration-induced tumor motion is a major obstacle for achieving high-precision radiotherapy of cancers in the thoracic and abdominal regions. Surrogate-based estimation and tracking methods are commonly used in radiotherapy, but with limited understanding of quantified correlation to tumor motion. In this study, we propose a method to simultaneously track the lung tumor and external surrogates to evaluate their spatial correlation in a quantitative way using dynamic MRI, which allows real-time acquisition without ionizing radiation exposure...
December 15, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29238628/intraprostatic-fiducials-compared-with-bony-anatomy-and-skin-marks-for-image-guided-radiation-therapy-of-prostate-cancer
#16
Juliette Moreau, Julian Biau, Jean-Louis Achard, Ivan Toledano, Charles Benhaim, Fabrice Kwiatkowski, Geneviève Loos, Michel Lapeyre
Purpose Prostate motion occurs during radiotherapy for localized prostate cancer. We evaluated the input of intraprostatic fiducials for image-guided radiation therapy and compared it with bony anatomy and skin marks. Methods Eleven patients were implanted with three fiducial markers in the prostate. Daily sets of orthogonal kV-kV images were compared with digitally reconstructed radiography. Data were recorded for skin marks, bony anatomy, and fiducial markers. The variations were analyzed along three principal axes (left-right: LR, superoinferior: SI, and anteroposterior: AP)...
October 12, 2017: Curēus
https://www.readbyqxmd.com/read/29229307/localizing-implanted-fiducial-markers-using-undersampled-co-rasor-mr-imaging
#17
Evan McNabb, Raimond Wong, Michael D Noseworthy
The goal of this work was to use an undersampled, dual-plane centre-out radial sampling acquisition pulse sequence, with off-resonance reception, to localize fiducial markers with reduced acquisition time. Two iterative reconstruction techniques, conjugate gradient CG-SENSE and the variational penalty Total Generalized Variation (TGV), were investigated to minimize the undersampling artifacts in off-resonant radialimaging. Simulations of a field perturber were performed at sub-millimeter resolution and reconstructed to display signal pileups that can be radially compressed towards the geometric center of the perturber for high contrast visualization, but contrast is non-recoverable as the echo time increases...
December 8, 2017: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/29219593/first-dark-matter-search-results-from-the-xenon1t-experiment
#18
E Aprile, J Aalbers, F Agostini, M Alfonsi, F D Amaro, M Anthony, F Arneodo, P Barrow, L Baudis, B Bauermeister, M L Benabderrahmane, T Berger, P A Breur, A Brown, A Brown, E Brown, S Bruenner, G Bruno, R Budnik, L Bütikofer, J Calvén, J M R Cardoso, M Cervantes, D Cichon, D Coderre, A P Colijn, J Conrad, J P Cussonneau, M P Decowski, P de Perio, P Di Gangi, A Di Giovanni, S Diglio, G Eurin, J Fei, A D Ferella, A Fieguth, W Fulgione, A Gallo Rosso, M Galloway, F Gao, M Garbini, R Gardner, C Geis, L W Goetzke, L Grandi, Z Greene, C Grignon, C Hasterok, E Hogenbirk, J Howlett, R Itay, B Kaminsky, S Kazama, G Kessler, A Kish, H Landsman, R F Lang, D Lellouch, L Levinson, Q Lin, S Lindemann, M Lindner, F Lombardi, J A M Lopes, A Manfredini, I Mariş, T Marrodán Undagoitia, J Masbou, F V Massoli, D Masson, D Mayani, M Messina, K Micheneau, A Molinario, K Morå, M Murra, J Naganoma, K Ni, U Oberlack, P Pakarha, B Pelssers, R Persiani, F Piastra, J Pienaar, V Pizzella, M-C Piro, G Plante, N Priel, L Rauch, S Reichard, C Reuter, B Riedel, A Rizzo, S Rosendahl, N Rupp, R Saldanha, J M F Dos Santos, G Sartorelli, M Scheibelhut, S Schindler, J Schreiner, M Schumann, L Scotto Lavina, M Selvi, P Shagin, E Shockley, M Silva, H Simgen, M V Sivers, A Stein, S Thapa, D Thers, A Tiseni, G Trinchero, C Tunnell, M Vargas, N Upole, H Wang, Z Wang, Y Wei, C Weinheimer, J Wulf, J Ye, Y Zhang, T Zhu
We report the first dark matter search results from XENON1T, a ∼2000-kg-target-mass dual-phase (liquid-gas) xenon time projection chamber in operation at the Laboratori Nazionali del Gran Sasso in Italy and the first ton-scale detector of this kind. The blinded search used 34.2 live days of data acquired between November 2016 and January 2017. Inside the (1042±12)-kg fiducial mass and in the [5,40]  keV_{nr} energy range of interest for weakly interacting massive particle (WIMP) dark matter searches, the electronic recoil background was (1...
November 3, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/29218332/evaluating-author-and-user-experience-for-an-audio-haptic-system-for-annotation-of-physical-models
#19
James M Coughlan, Joshua Miele
We describe three usability studies involving a prototype system for creation and haptic exploration of labeled locations on 3D objects. The system uses a computer, webcam, and fiducial markers to associate a physical 3D object in the camera's view with a predefined digital map of labeled locations ("hotspots"), and to do real-time finger tracking, allowing a blind or visually impaired user to explore the object and hear individual labels spoken as each hotspot is touched. This paper describes: (a) a formative study with blind users exploring pre-annotated objects to assess system usability and accuracy; (b) a focus group of blind participants who used the system and, through structured and unstructured discussion, provided feedback on its practicality, possible applications, and real-world potential; and (c) a formative study in which a sighted adult used the system to add labels to on-screen images of objects, demonstrating the practicality of remote annotation of 3D models...
October 2017: ASSETS Association for Computing Machinery
https://www.readbyqxmd.com/read/29214516/advances-in-stereotactic-navigation-for-pelvic-surgery
#20
A R Wijsmuller, L G C Romagnolo, V Agnus, C Giraudeau, A G F Melani, B Dallemagne, J Marescaux
BACKGROUND: Stereotactic navigation could improve the quality of surgery for rectal cancer. Critical challenges related to soft tissue stereotactic pelvic navigation include the potential difference in patient anatomy between intraoperative lithotomy and preoperative supine position for imaging. The objective of this study was to determine the difference in patient anatomy, sacral tilt, and skin fiducial position between these different patient positions and to investigate the feasibility and optimal set-up for stereotactic pelvic navigation...
December 6, 2017: Surgical Endoscopy
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