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https://www.readbyqxmd.com/read/28434799/improved-outcomes-with-dose-escalation-in-localized-prostate-cancer-treated-with-precision-image-guided-radiotherapy
#1
Hamid Raziee, Fabio Y Moraes, Jure Murgic, Melvin L K Chua, Melania Pintilie, Peter Chung, Cynthia Ménard, Andrew Bayley, Mary Gospodarowicz, Padraig Warde, Tim Craig, Charles Catton, Robert G Bristow, David A Jaffray, Alejandro Berlin
BACKGROUND AND PURPOSE: Dose-escalated radiotherapy (DE) improves outcomes in localized prostate cancer (PCa). The impact of DE in the context of image-guided radiotherapy (IGRT) remains unknown. Herein, we determined outcomes of three sequential cohorts treated with progressive DE-IGRT. MATERIALS AND METHODS: We analyzed data from 1998 to 2012. Patients treated with radical radiotherapy were included, with three sequential institutional schedules: (A) 75.6Gy, (B) 79...
April 20, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28429161/on-the-in-vivo-function-of-the-mitral-heart-valve-leaflet-insights-into-tissue-interstitial-cell-biomechanical-coupling
#2
Chung-Hao Lee, Will Zhang, Kristen Feaver, Robert C Gorman, Joseph H Gorman, Michael S Sacks
There continues to be a critical need for developing data-informed computational modeling techniques that enable systematic evaluations of mitral valve (MV) function. This is important for a better understanding of MV organ-level biomechanical performance, in vivo functional tissue stresses, and the biosynthetic responses of MV interstitial cells (MVICs) in the normal, pathophysiological, and surgically repaired states. In the present study, we utilized extant ovine MV population-averaged 3D fiducial marker data to quantify the MV anterior leaflet (MVAL) deformations in various kinematic states...
April 20, 2017: Biomechanics and Modeling in Mechanobiology
https://www.readbyqxmd.com/read/28414927/integration-of-free-hand-3d-ultrasound-and-mobile-c-arm-cone-beam-ct-feasibility-and-characterization-for-real-time-guidance-of-needle-insertion
#3
E Marinetto, A Uneri, T De Silva, S Reaungamornrat, W Zbijewski, A Sisniega, S Vogt, G Kleinszig, J Pascau, J H Siewerdsen
This work presents development of an integrated ultrasound (US)-cone-beam CT (CBCT) system for image-guided needle interventions, combining a low-cost ultrasound system (Interson VC 7.5MHz, Pleasanton, CA) with a mobile C-arm for fluoroscopy and CBCT via use of a surgical tracker. Imaging performance of the ultrasound system was characterized in terms of depth-dependent contrast-to-noise ratio (CNR) and spatial resolution. US-CBCT system was evaluated in phantom studies simulating three needle-based procedures: drug delivery, tumor ablation, and lumbar puncture...
April 3, 2017: Computerized Medical Imaging and Graphics: the Official Journal of the Computerized Medical Imaging Society
https://www.readbyqxmd.com/read/28403196/validation-of-automatic-measurement-of-qt-interval-variability
#4
Peter R Rijnbeek, Marten E van den Berg, Gerard van Herpen, Henk J Ritsema van Eck, Jan A Kors
BACKGROUND: Increased variability of beat-to-beat QT-interval durations on the electrocardiogram (ECG) has been associated with increased risk for fatal and non-fatal cardiac events. However, techniques for the measurement of QT variability (QTV) have not been validated since a gold standard is not available. In this study, we propose a validation method and illustrate its use for the validation of two automatic QTV measurement techniques. METHODS: Our method generates artificial standard 12-lead ECGs based on the averaged P-QRS-T complexes from a variety of existing ECG signals, with simulated intrinsic (QT interval) and extrinsic (noise, baseline wander, signal length) variations...
2017: PloS One
https://www.readbyqxmd.com/read/28399830/electromagnetic-navigation-bronchoscopy-to-access-lung-lesions-in-1-000-subjects-first-results-of-the-prospective-multicenter-navigate-study
#5
Sandeep J Khandhar, Mark R Bowling, Javier Flandes, Thomas R Gildea, Kristin L Hood, William S Krimsky, Douglas J Minnich, Septimiu D Murgu, Michael Pritchett, Eric M Toloza, Momen M Wahidi, Jennifer J Wolvers, Erik E Folch
BACKGROUND: Electromagnetic navigation bronchoscopy (ENB) is an image-guided, minimally invasive approach that uses a flexible catheter to access pulmonary lesions. METHODS: NAVIGATE is a prospective, multicenter study of the superDimension™ navigation system. A prespecified 1-month interim analysis of the first 1,000 primary cohort subjects enrolled at 29 sites in the United States and Europe is described. Enrollment and 24-month follow-up are ongoing. RESULTS: ENB index procedures were conducted for lung lesion biopsy (n = 964), fiducial marker placement (n = 210), pleural dye marking (n = 17), and/or lymph node biopsy (n = 334; primarily endobronchial ultrasound-guided)...
April 11, 2017: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/28398630/mitigating-differential-baseline-shifts-in-locally-advanced-lung-cancer-patients-using-an-average-anatomy-model
#6
Mehrsima Abdoli, Simon R van Kranen, Uros Stankovic, Maddalena M G Rossi, Jose S A Belderbos, Jan-Jakob Sonke
BACKGROUND AND PURPOSE: Differential baseline shifts between primary tumor and involved lymph nodes in locally advanced lung cancer patients compromise the accuracy of radiotherapy. The purpose of this study was to evaluate the performance of an average anatomy model (AAM) derived from repeat imaging and deformable registration to reduce these geometrical uncertainties. METHODS AND MATERIALS: An in-house implementation of a B-Spline deformable image registration (DIR) algorithm was first validated using three different validation approaches: 1) a circle method to test the consistency of the DIR, 2) fiducial marker target registration error, and 3) the recovery of a known deformation vector field (DVF)...
April 11, 2017: Medical Physics
https://www.readbyqxmd.com/read/28391669/endoscopic-ultrasound-guided-direct-intervention-for-solid-pancreatic-tumors
#7
REVIEW
Jimin Han, Kenneth J Chang
Development and use of linear-array echoendoscope and endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) have made endoscopic ultrasound (EUS) more of an interventional procedure than a purely diagnostic procedure. This is a literature review of previously published clinical studies on EUS-guided direct intervention for solid pancreatic tumors, including EUS-guided fine needle injection (EUS-FNI) of antitumor agents, EUS-guided fiducial marker placement, EUS-guided brachytherapy and EUS-guided tumor ablation...
March 2017: Clinical Endoscopy
https://www.readbyqxmd.com/read/28390652/a-fast-noise-tolerant-ecg-feature-recognition-algorithm-based-on-probabilistic-analysis-of-gradient-discontinuity
#8
Peter A Watterson
PURPOSE: Improvement in real-time electrocardiogram (ECG) interpretation is still needed, especially for QT estimation. This paper proposes a fast algorithm for ECG feature recognition, based on locating turning points in the waveform gradient. METHODS: The algorithm places the fiducial point at the maximal value of a probabilistic decision function, assessing line intervals of best fit before and after the point and the point location relative to R-wave peaks already found...
March 14, 2017: Journal of Electrocardiology
https://www.readbyqxmd.com/read/28386757/contact-less-stylus-for-surgical-navigation-registration-without-digitization
#9
Elvis C S Chen, Burton Ma, Terry M Peters
PURPOSE: We present a laser-based, contact-less, stylus for the purpose of fiducial registration and digitization in the context of surgical navigation. METHODS: We augmented a laser pointer with a spatial measurement device and used the laser beam as a means to locate a fiducial in 3D space. We developed a method for calibrating the orientation of the laser beam with respect to its attached tracking target. Digitization of a fiducial was formulated as a line intersection problem, and registration was formulated as a point-to-line registration problem...
April 6, 2017: International Journal of Computer Assisted Radiology and Surgery
https://www.readbyqxmd.com/read/28380995/wavelength-calibration-of-a-high-resolution-spectrograph-with-a-partially-stabilized-15-ghz-astrocomb-from-550-to-890-nm
#10
Richard A McCracken, Éric Depagne, Rudolf B Kuhn, Nicolas Erasmus, Lisa A Crause, Derryck T Reid
A visible astrocomb spanning 555-890 nm has been implemented on the 10-m Southern African Large Telescope, delivering complete calibration of one channel of its high-resolution spectrograph and an accurate determination of its resolving power. A novel co-coupling method allowed simultaneous observation of on-sky, Th-Ar lamp and astrocomb channels, reducing the wavelength calibration uncertainty by a factor of two compared to that obtained using only Th-Ar lines. The excellent passive stability of the master frequency comb laser enabled broadband astrocomb generation without the need for carrier-envelope offset frequency locking, and an atomically referenced narrow linewidth diode laser provided an absolute fiducial marker for wavelength calibration...
March 20, 2017: Optics Express
https://www.readbyqxmd.com/read/28379660/quality-of-life-after-post-prostatectomy-intensity-modulated-radiation-therapy-to-the-prostate-bed-with-or-without-the-use-of-gold-fiducial-markers-for-image-guidance-or-higher-total-radiotherapy-doses
#11
Yazan A Abuodeh, Arash O Naghavi, Tzu-Hua Juan, Zhenjun Ma, Richard B Wilder
PURPOSE: To evaluate quality of life (QoL) after post-prostatectomy intensity modulated radiation therapy (IMRT) in the "adjuvant" setting starting within 4 months of radical prostatectomy for adverse features; and "salvage" setting for a PSA≥0.2ng/mL. MATERIALS AND METHODS: Retrospective review of 130 patients who underwent IMRT to the prostate bed±gold fiducial marker placement for image guidance to 64.8-72.0Gy (median, 70.2Gy) between 2004 and 2013. Higher doses were defined as 70...
April 6, 2017: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/28374321/reduced-late-urinary-toxicity-with-high-dose-intensity-modulated-radiotherapy-using-intra-prostate-fiducial-markers-for-localized-prostate-cancer
#12
A Zapatero, M Roch, D Büchser, P Castro, L Fernández-Banda, G Pozo, O Liñán, C Martin de Vidales, A Cruz-Conde, F García-Vicente
BACKGROUND/PURPOSE: To evaluate the impact of intensity-modulated radiotherapy (IMRT) with intra-prostate fiducial markers image-guided radiotherapy (IGRT) on the incidence of late urinary toxicity compared to 3D conformal radiotherapy (3DCRT) for patients with prostate cancer (PC). METHODS AND MATERIALS: We selected 733 consecutive patients with localized PC treated with dose-escalation radiotherapy between 2001 and 2014. Eligibility criteria were radiation dose >72...
April 3, 2017: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/28370061/implementation-of-facial-recognition-with-microsoft-kinect-v2-sensor-for-patient-verification
#13
Evan Silverstein, Michael Snyder
PURPOSE: To present a straightforward implementation of facial recognition using the Microsoft Kinect v2 sensor for the purpose of patient identification in a radiotherapy setting. MATERIALS AND METHODS: A facial recognition system was created with the Microsoft Kinect v2 using a facial mapping library distributed with the Kinect v2 SDK as a basis for the algorithm. The system extracts 31 fiducial points representing various facial landmarks which are used in both the creation of a reference data set and subsequent evaluations of real-time sensor data in the matching algorithm...
March 30, 2017: Medical Physics
https://www.readbyqxmd.com/read/28361324/coffee-the-key-to-safer-image-guided-surgery-a-granular-jamming-cap-for-non-invasive-rigid-fixation-of-fiducial-markers-to-the-patient
#14
Patrick S Wellborn, Neal P Dillon, Paul T Russell, Robert J Webster
PURPOSE: Accurate image guidance requires a rigid connection between tracked fiducial markers and the patient, which cannot be guaranteed by current non-invasive attachment techniques. We propose a new granular jamming approach to firmly, yet non-invasively, connect fiducials to the patient. METHODS: Our granular jamming cap surrounds the head and conforms to the contours of the patient's skull. When a vacuum is drawn, the device solidifies in a manner conceptually like a vacuum-packed bag of ground coffee, providing a rigid structure that can firmly hold fiducial markers to the patient's skull...
March 30, 2017: International Journal of Computer Assisted Radiology and Surgery
https://www.readbyqxmd.com/read/28359341/monitoring-of-breathing-motion-in-image-guided-pbs-proton-therapy-comparative-analysis-of-optical-and-electromagnetic-technologies
#15
Giovanni Fattori, Sairos Safai, Pablo Fernández Carmona, Marta Peroni, Rosalind Perrin, Damien Charles Weber, Antony John Lomax
BACKGROUND: Motion monitoring is essential when treating non-static tumours with pencil beam scanned protons. 4D medical imaging typically relies on the detected body surface displacement, considered as a surrogate of the patient's anatomical changes, a concept similarly applied by most motion mitigation techniques. In this study, we investigate benefits and pitfalls of optical and electromagnetic tracking, key technologies for non-invasive surface motion monitoring, in the specific environment of image-guided, gantry-based proton therapy...
March 31, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/28343301/comparison-of-optical-see-through-head-mounted-displays-for-surgical-interventions-with-object-anchored-2d-display
#16
Long Qian, Alexander Barthel, Alex Johnson, Greg Osgood, Peter Kazanzides, Nassir Navab, Bernhard Fuerst
PURPOSE: Optical see-through head-mounted displays (OST-HMD) feature an unhindered and instantaneous view of the surgery site and can enable a mixed reality experience for surgeons during procedures. In this paper, we present a systematic approach to identify the criteria for evaluation of OST-HMD technologies for specific clinical scenarios, which benefit from using an object-anchored 2D-display visualizing medical information. METHODS: Criteria for evaluating the performance of OST-HMDs for visualization of medical information and its usage are identified and proposed...
March 25, 2017: International Journal of Computer Assisted Radiology and Surgery
https://www.readbyqxmd.com/read/28342124/laparoscopic-image-based-navigation-for-microwave-ablation-of-liver-tumors-a-multi-center-study-laparoscopic-navigation-for-hepatic-ablation
#17
Tinguely Pascale, Fusaglia Matteo, Freedman Jacob, Banz Vanessa, Weber Stefan, Candinas Daniel, Nilsson Henrik
BACKGROUND: Stereotactic navigation technology has been proposed to augment accuracy in targeting intrahepatic lesions for local ablation therapy. This retrospective study evaluated accuracy, efficacy, and safety when using laparoscopic image-guided microwave ablation (LIMA) for malignant liver tumors. METHODS: All patients treated for malignant liver lesions using LIMA at two European centers between 2013 and 2015 were included for analysis. A landmark-based registration technique was applied for intraoperative tumor localization and positioning of ablation probes...
March 24, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/28335794/tumor-motion-changes-in-stereotactic-body-radiotherapy-for-liver-tumors-an-evaluation-based-on-four-dimensional-cone-beam-computed-tomography-and-fiducial-markers
#18
Yoshinobu Shimohigashi, Ryo Toya, Tetsuo Saito, Osamu Ikeda, Masato Maruyama, Keisuke Yonemura, Yuji Nakaguchi, Yudai Kai, Yasuyuki Yamashita, Natsuo Oya, Fujio Araki
BACKGROUND: For stereotactic body radiation therapy (SBRT) of liver tumors, tumor motion induced by respiration must be taken into account in planning and treatment. We evaluated whether liver tumor motion at the planning simulation represents liver tumor motion during SBRT, and estimated inter- and intrafractional tumor motion changes in patients undergoing liver SBRT. METHODS: Ten patients underwent four-dimensional cone-beam computed tomography (4D-CBCT) image-guided liver SBRT with abdominal compression (AC) and fiducial markers...
March 23, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/28335382/feasibility%C3%A2-of%C3%A2-assessing%C3%A2-diet%C3%A2-with%C3%A2-a%C3%A2-mobile%C3%A2-food%C3%A2-record%C3%A2-for%C3%A2-adolescents%C3%A2-and%C3%A2-young%C3%A2-adults%C3%A2-with%C3%A2-down%C3%A2-syndrome
#19
Katherine E Bathgate, Jill L Sherriff, Helen Leonard, Satvinder S Dhaliwal, Edward J Delp, Carol J Boushey, Deborah A Kerr
Technology-based methods for assessing diet in those with disability remains largely unexplored. The aim was to assess the feasibility of assessing diet with an image-based mobile food record application (mFR) in 51 adolescents and young adults with Down syndrome (PANDs). Adherence was also assessed with the instruction to include a fiducial marker object in the before and after eating images. The PANDs sample completed a four-day mFR and results were compared with a sample of young adults from the Connecting Health and Technology study (CHAT, n = 244)...
March 13, 2017: Nutrients
https://www.readbyqxmd.com/read/28332159/electromagnetically-tracked-personalized-templates-for-surgical-navigation
#20
Andrew W L Dickinson, Michelle L Zec, David R Pichora, Brian J Rasquinha, Randy E Ellis
PURPOSE: An electromagnetic (EM) surgical tracking system was developed for orthopedic navigation. The reportedly poor accuracy of point-based EM navigation was improved by using anatomical impressions, which were EM-tracked personalized templates. Lines, rather than points, were consistently used for calibration and error evaluation. METHODS: Technical accuracy was tested using models derived from CT scans of ten cadaver shoulders. Tracked impressions were first designed, calibrated, and tested using lines as fiducial objects...
March 22, 2017: International Journal of Computer Assisted Radiology and Surgery
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