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https://www.readbyqxmd.com/read/28812120/risk-adapted-robotic-stereotactic-body-radiation-therapy-for-inoperable-early-stage-non-small-cell-lung-cancer
#1
Susanne Temming, Martin Kocher, Erich Stoelben, Lars Hagmeyer, De-Hua Chang, Konrad Frank, Khosro Hekmat, Juergen Wolf, Wolfgang W Baus, Robert Semrau, Christian Baues, S Marnitz
PURPOSE: To evaluate efficacy and toxicity of stereotactic body radiation therapy (SBRT) with CyberKnife® (Accuray, Sunnyvale, CA, USA) in a selected cohort of primary, medically inoperable early-stage non-small cell lung cancer (NSCLC) patients. METHODS: From 2012 to 2016, 106 patients (median age 74 years, range 50-94 years) with primary NSCLC were treated with SBRT using CyberKnife®. Histologic confirmation was available in 87 patients (82%). For mediastinal staging, 92 patients (87%) underwent (18)F-fluorodeoxyglucose positron-emission tomography (18-FDG-PET) and/or endobronchial ultrasound (EBUS)-guided lymph node biopsy or mediastinoscopy...
August 15, 2017: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/28808749/bioxmark-for-high-precision-radiotherapy-in-an-orthotopic-pancreatic-tumor-mouse-model-experiences-with-a-liquid-fiducial-marker
#2
S Dobiasch, S Kampfer, R Burkhardt, D Schilling, T E Schmid, J J Wilkens, S E Combs
BACKGROUND AND PURPOSE: High-precision radiotherapy (RT) requires precise positioning, particularly with high single doses. Fiducial markers in combination with onboard imaging are excellent tools to support this. The purpose of this study is to establish a pancreatic cancer mouse model for high-precision image-guided RT (IGRT) using the liquid fiducial marker BioXmark (Nanovi, Kongens Lyngby, Denmark). METHODS: In an animal-based cancer model, different volumes of BioXmark (10-50 µl), application forms, and imaging modalities-cone-beam computer tomography (CBCT) incorporated in either the Small Animal Radiation Research Platform (SARRP) or the small-animal micro-CT Scanner (SkyScan; Bruker, Brussels, Belgium)-as well as subsequent RT with the SARRP system were analyzed to derive recommendations for BioXmark...
August 14, 2017: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/28807758/insulinoma-enucleation-after-echoendoscopic-fiducial-placement
#3
Sébastien Gaujoux, Seray Genc, Sarah Leblanc, Bertrand Dousset, Frédéric Prat
No abstract text is available yet for this article.
August 11, 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/28803447/registration-free-automatic-identification-of-gold-fiducial-markers-in-mri-target-delineation-images-for-prostate-radiotherapy
#4
Christian Gustafsson, Juha Korhonen, Emilia Persson, Adalsteinn Gunnlaugsson, Tufve Nyholm, Lars E Olsson
PURPOSE: The superior soft tissue contrast of magnetic resonance imaging (MRI) compared to computed tomography (CT) has urged the integration of MRI and elimination of CT in radiotherapy treatment (RT) for prostate. An intraprostatic gold fiducial marker (GFM) appear hyperintense on CT. On T2 weighted (T2w) MRI target delineation images the GFM appear as a small signal void similar to calcifications and post biopsy fibrosis. It can therefore be difficult to identify the markers without CT...
August 13, 2017: Medical Physics
https://www.readbyqxmd.com/read/28801767/experimental-validation-of-predicted-application-accuracies-for-computer-assisted-cas-intraoperative-navigation-with-paired-point-registration
#5
Martina Perwög, Zoltan Bardosi, Wolfgang Freysinger
PURPOSE: The target registration error (TRE) is a crucial parameter to estimate the potential usefulness of computer-assisted navigation intraoperatively. Both image-to-patient registration on base of rigid-body registration and TRE prediction methods are available for spatially isotropic and anisotropic data. This study presents a thorough validation of data obtained in an experimental operating room setting with CT images. METHODS: Optical tracking was used to register a plastic skull, an anatomic specimen, and a volunteer to their respective CT images...
August 11, 2017: International Journal of Computer Assisted Radiology and Surgery
https://www.readbyqxmd.com/read/28770553/perioperative-technical-complications-in-deep-brain-stimulation-surgeries
#6
Onur Alptekin, Ersoy Kocabicak, Felix S Gubler, Linda Ackermans, Pieter L Kubben, Yasin Temel
AIM: Deep brain stimulation (DBS) surgeries are multi-faceted and the various steps are interconnected. Since its first implementation, the method of DBS surgery has undergone changes. We have encountered several expected and also non-expected perioperative technical complications in the past seventeen years. Here, we describe the stereotactic frame, stereotactic localizer and planning station related complications and how we have managed them as much as possible. MATERIAL AND METHODS: This study is a retrospective qualitative analysis of the documented technical events encountered during DBS surgeries from 1999 onwards...
June 14, 2017: Turkish Neurosurgery
https://www.readbyqxmd.com/read/28756594/decreased-acute-toxicities-of-intensity-modulated-radiation-therapy-for-localized-prostate-cancer-with-prostate-based-versus-bone-based-image-guidance
#7
Kiyonao Nakamura, Takashi Mizowaki, Haruo Inokuchi, Itaru Ikeda, Takahiro Inoue, Tomomi Kamba, Osamu Ogawa, Masahiro Hiraoka
BACKGROUND: Intensity-modulated radiation therapy (IMRT) is a major therapeutic option for localized prostate cancer. Image-guided radiation therapy (IGRT) allows tumor visualization and corrects the errors caused by daily internal movement of the prostate. The current study retrospectively compared the acute toxicities and biochemical tumor control outcomes of prostate IMRT achieved using two IGRT techniques: bony structure-based IGRT (B-IGRT) and prostate-based IGRT (P-IGRT). METHODS: Between February 2011 and July 2014, 96 patients with low- or intermediate-risk prostate cancer were treated using P-IGRT based on cone-beam computed tomography (CBCT; 76 Gy) without fiducial markers...
July 29, 2017: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28756247/autom-a-novel-automatic-platform-for-electron-tomography-reconstruction
#8
Renmin Han, Xiaohua Wan, Zihao Wang, Yu Hao, Jingrong Zhang, Yu Chen, Xin Gao, Zhiyong Liu, Fei Ren, Fei Sun, Fa Zhang
We have developed a software package towards automatic electron tomography (ET): Automatic Tomography (AuTom). The presented package has the following characteristics: accurate alignment modules for marker-free datasets containing substantial biological structures; fully automatic alignment modules for datasets with fiducial markers; wide coverage of reconstruction methods including a new iterative method based on the compressed-sensing theory that suppresses the "missing wedge" effect; and multi-platform acceleration solutions that support faster iterative algebraic reconstruction...
July 26, 2017: Journal of Structural Biology
https://www.readbyqxmd.com/read/28754888/gyrocardiography-a-new-non-invasive-monitoring-method-for-the-assessment-of-cardiac-mechanics-and-the-estimation-of-hemodynamic-variables
#9
Mojtaba Jafari Tadi, Eero Lehtonen, Antti Saraste, Jarno Tuominen, Juho Koskinen, Mika Teräs, Juhani Airaksinen, Mikko Pänkäälä, Tero Koivisto
Gyrocardiography (GCG) is a new non-invasive technique for assessing heart motions by using a sensor of angular motion - gyroscope - attached to the skin of the chest. In this study, we conducted simultaneous recordings of electrocardiography (ECG), GCG, and echocardiography in a group of subjects consisting of nine healthy volunteer men. Annotation of underlying fiducial points in GCG is presented and compared to opening and closing points of heart valves measured by a pulse wave Doppler. Comparison between GCG and synchronized tissue Doppler imaging (TDI) data shows that the GCG signal is also capable of providing temporal information on the systolic and early diastolic peak velocities of the myocardium...
July 28, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28739211/investigating-the-surface-dose-contribution-of-intrafractional-kv-imaging-in-cyberknife-based-stereotactic-radiosurgery
#10
Abdulmecit Canbolat, Faruk Zorlu, Pervin Hurmuz, Mete Yeginer, Gokhan Ozyigit
CyberKnife treatment consists of hundreds of noncoplanar beams and numerous intrafractional images that can be taken during a single treatment fraction; thus, doses because of imaging should be considered in this technique. The aim of this study is to investigate the in-field and out-of-field surface doses induced from kV imaging system during stereotactic radiosurgery (SRS) treatment. The imaging-induced surface doses were measured at the center of the imaging field and within ±15-cm distance from the center in both craniocaudal and lateral directions...
July 21, 2017: Medical Dosimetry: Official Journal of the American Association of Medical Dosimetrists
https://www.readbyqxmd.com/read/28718001/a-new-device-for-fiducial-registration-of-image-guided-navigation-system-for-liver-rfa
#11
Nobutaka Doba, Hiroyuki Fukuda, Kazushi Numata, Yoshiteru Hao, Kouji Hara, Akito Nozaki, Masaaki Kondo, Makoto Chuma, Katsuaki Tanaka, Shigeo Takebayashi, Norihiro Koizumi, Akira Kobayashi, Junichi Tokuda, Shin Maeda
PURPOSE: Radiofrequency ablation for liver tumors (liver RFA) is widely performed under ultrasound guidance. However, discriminating between the tumor and the needle is often difficult because of cavitation caused by RFA-induced coagulation. An unclear ultrasound image can lead to complications and tumor residue. Therefore, image-guided navigation systems based on fiducial registration have been developed. Fiducial points are usually set on a patient's skin. But the use of internal fiducial points can improve the accuracy of navigation...
July 17, 2017: International Journal of Computer Assisted Radiology and Surgery
https://www.readbyqxmd.com/read/28716090/clinical-workflow-for-mr-only-simulation-and-planning-in-prostate
#12
Neelam Tyagi, Sandra Fontenla, Michael Zelefsky, Marcia Chong-Ton, Kyle Ostergren, Niral Shah, Lizette Warner, Mo Kadbi, Jim Mechalakos, Margie Hunt
PURPOSE: To describe the details and experience of implementing a MR-only workflow in the clinic for simulation and planning of prostate cancer patients. METHODS: Forty-eight prostate cancer patients from June 2016 - Dec 2016 receiving external beam radiotherapy were scheduled to undergo MR-only simulation. MR images were acquired for contouring (T2w axial, coronal, sagittal), synthetic-CT generation (3D FFE-based) and fiducial identification (3D bFFE-based). The total acquisition time was 25 min...
July 17, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/28707918/large-electroweak-corrections-to-vector-boson-scattering-at-the-large-hadron-collider
#13
Benedikt Biedermann, Ansgar Denner, Mathieu Pellen
For the first time full next-to-leading-order electroweak corrections to off-shell vector-boson scattering are presented. The computation features the complete matrix elements, including all nonresonant and off-shell contributions, to the electroweak process pp→μ^{+}ν_{μ}e^{+}ν_{e}jj and is fully differential. We find surprisingly large corrections, reaching -16% for the fiducial cross section, as an intrinsic feature of the vector-boson-scattering processes. We elucidate the origin of these large electroweak corrections upon using the double-pole approximation and the effective vector-boson approximation along with leading-logarithmic corrections...
June 30, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28702337/linear-ebus-guided-fiducial-marker-placement-to-guide-radiotherapy-for-endobronchial-radiographically-occult-synchronous-primary-squamous-cell-carcinoma-of-the-lung
#14
David Maurice Chambers, Gregory John Pfister, Umair Ahmad Gauhar
Radiation therapy has emerged as a useful alternative therapy for patients with early-stage, non-resectable lung cancer. In patients whose malignancies are difficult to localize on computed tomography imaging, such therapy becomes difficult. Fiducial markers are frequently placed in peripheral pulmonary lesions to assist radiation therapy. Although placement of markers under linear endobronchial ultrasonography within mediastinal and hilar lymph nodes has been reported, no strategy has been described to assist radiotherapy of purely endobronchial tumors...
2017: Respiratory Medicine Case Reports
https://www.readbyqxmd.com/read/28700740/navigation-accuracy-after-automatic-and-hybrid-surface-registration-in-sinus-and-skull-base-surgery
#15
Tanja Daniela Grauvogel, Paul Engelskirchen, Wiebke Semper-Hogg, Juergen Grauvogel, Roland Laszig
OBJECTIVE: Computer-aided-surgery in ENT surgery is mainly used for sinus surgery but navigation accuracy still reaches its limits for skull base procedures. Knowledge of navigation accuracy in distinct anatomical regions is therefore mandatory. This study examined whether navigation accuracy can be improved in specific anatomical localizations by using hybrid registration technique. STUDY DESIGN: Experimental phantom study. SETTING: Operating room...
2017: PloS One
https://www.readbyqxmd.com/read/28697122/the-emerging-role-of-endoscopists-in-treating-unresectable-pancreatic-cancer
#16
Adrianne Tsen, Matthew Van Norman, Sreedevi Atluri, Laura Rosenkranz
Pancreatic adenocarcinoma is the eighth leading cause of cancer deaths worldwide in men and ninth leading cause in women. Surgical resection offers the only chance of potential cure; however, only 9.4% of patients present at the localized, resectable stage, whereas the rest present at the locally advanced or metastatic, unresectable stages. Because of the guarded outcomes following systemic chemoradiation and the associated systemic toxicities, locoregional therapies have recently gained popularity. Various endoscopic techniques (endoscopic ultrasound [EUS]-guided ablative therapies, fine-needle instillation of antitumor agents, stereotactic body radiation therapy with EUS-guided fiducial marker placement, and EUS-guided brachytherapy) have been explored over the past several years...
August 2017: Pancreas
https://www.readbyqxmd.com/read/28690355/evaluation-of-lung-tumor-motion-management-in-radiation-therapy-with-dynamic-mri
#17
Seyoun Park, Rana Farah, Steven M Shea, Erik Tryggestad, Russell Hales, Junghoon Lee
Surrogate-based tumor motion estimation and tracing methods are commonly used in radiotherapy despite the lack of continuous real time 3D tumor and surrogate data. In this study, we propose a method to simultaneously track the tumor and external surrogates with dynamic MRI, which allows us to evaluate their reproducible correlation. Four MRI-compatible fiducials are placed on the patient's chest and upper abdomen, and multi-slice 2D cine MRIs are acquired to capture the lung and whole tumor, followed by two-slice 2D cine MRIs to simultaneously track the tumor and fiducials, all in sagittal orientation...
February 11, 2017: Proceedings of SPIE
https://www.readbyqxmd.com/read/28675442/a-generic-multi-module-phantom-for-testing-geometry-of-a-linac-c-arm-as-a-part-of-quality-control-in-radiotherapy
#18
Zbisław Tabor, Damian Kabat, Monika Tomaszuk, Radosław Kycia, Zbigniew Latała
PURPOSE: To develop an assumption-free methodology for testing geometry of linacs. METHODS: The problem of projecting a fiducial positioned in a predefined point in a 3D space and attached rigidly to a treatment table of a radiotherapeutic device onto an imaging plane with unknown characteristics from a source with unknown coordinates is formulated. The problem of determining these unknowns is formulated as an optimization problem. The problem of determining the gantry/the collimator rotation axis and angle from projection of additional fiducials is also formulated and solved...
July 4, 2017: Medical Physics
https://www.readbyqxmd.com/read/28673889/presurgical-planning-for-supratentorial-lesions-with-free-slicer-software-and-sina-app
#19
Ji-Gang Chen, Kai-Wei Han, Dan-Feng Zhang, Zhen-Xing Li, Yi-Ming Li, Li-Jun Hou
BACKGROUND: Neuronavigation system is widely used in the localization of intracranial lesions with satisfactory accuracy. However, it's expensive and difficult to learn. Therefore, simple and practical augmented reality (AR) system using mobile devices might be an alternative technique. OBJECTIVE: We aim to introduce a mobile AR system for the localization of supratentorial lesions. Its practicability and accuracy were examined by clinical application in patients and comparison with standard neuronavigation system...
June 30, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28671659/highly-multiplexed-super-resolution-imaging-of-t-cells-using-madstorm
#20
Jason Yi, Asit Manna, Valarie A Barr, Jennifer Hong, Keir C Neuman, Lawrence E Samelson
Imaging heterogeneous cellular structures using single molecule localization microscopy has been hindered by inadequate localization precision and multiplexing ability. Using fluorescent nano-diamond fiducial markers, we describe the drift correction and alignment procedures required to obtain high precision in single molecule localization microscopy. In addition, a new multiplexing strategy, madSTORM, is described in which multiple molecules are targeted in the same cell using sequential binding and elution of fluorescent antibodies...
June 24, 2017: Journal of Visualized Experiments: JoVE
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