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https://www.readbyqxmd.com/read/28914752/ct-attenuation-of-pericoronary-adipose-tissue-in-normal-versus-atherosclerotic-coronary-segments-as-defined-by-intravascular-ultrasound
#1
Mohamed Marwan, Michaela Hell, Annika Schuhbäck, Sören Gauss, Daniel Bittner, Tobias Pflederer, Stephan Achenbach
BACKGROUND: The factors influencing genesis of atherosclerosis at specific regions within the coronary arterial system are currently uncertain. Local mechanical factors such as shear stress as well as metabolic factors, including inflammatory mediators released from epicardial fat, have been proposed. We analyzed computed tomographic (CT) attenuation of pericoronary adipose tissue in normal versus atherosclerotic coronary segments as defined by intravascular ultrasound (IVUS). PATIENTS AND METHODS: We evaluated the data sets of 29 patients who were referred for invasive coronary angiography and in whom IVUS of 1 coronary vessel was performed for clinical reasons...
September 2017: Journal of Computer Assisted Tomography
https://www.readbyqxmd.com/read/28893302/comprehensive-target-geometric-errors-and-margin-assessment-in-stereotactic-partial-breast-irradiation
#2
Xin Zhen, Bo Zhao, Zhuoyu Wang, Robert Timmerman, Ann Spangler, Nathan Kim, Asal Rahimi, Xuejun Gu
BACKGROUND: Recently developed stereotactic partial breast irradiation (S-PBI) allows delivery of a high biologically potent dose to the target while sparing adjacent critical organs and normal tissue. With S-PBI tumoricidal doses, accurate and precise dose delivery is critical to achieve high treatment quality. This study is to investigate both rigid and non-rigid components of target geometric error and their corresponding margins in S-PBI and identify correlated clinical factors. METHODS: Forty-three early-stage breast cancer patients with implanted gold fiducial markers were enrolled in the study...
September 11, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/28890087/-therapeutic-innovations-in-radiation-oncology-for-localized-prostate-cancer
#3
G Créhange, L Cormier
Intensity-modulated radiation therapy, image-guided radiation therapy with fiducial markers and prostate brachytherapy allow the delivery of dose escalation for localized prostate cancer with very low rates of long-term toxicity and sequelae. Nowadays, modern radiotherapy techniques make it possible to shorten treatment time with hypofractionation, to better protect surrounding healthy tissues and to escalate the dose even further. Advances in radiotherapy are closely linked to advances in magnetic resonance imaging (MRI) and/or PET imaging...
September 7, 2017: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
https://www.readbyqxmd.com/read/28888826/intramural-duodenal-hematoma-post-eus-guided-placement-of-fiducial-radiopaque-markers
#4
Ihab I El Hajj, Jeffrey J Easler, Stuart Sherman, Mohammad Al-Haddad
No abstract text is available yet for this article.
August 24, 2017: Digestive and Liver Disease
https://www.readbyqxmd.com/read/28887836/a-novel-method-for-quantification-of-beam-s-eye-view-tumor-tracking-performance
#5
Yue-Houng Hu, Marios Myronakis, Joerg Rottmann, Adam Wang, Daniel Morf, Daniel Shedlock, Paul Baturin, Josh Star-Lack, Ross Berbeco
PURPOSE: In-treatment imaging using an electronic portal imaging device (EPID) can be used to confirm patient and tumor positioning. Real-time tumor tracking performance using current digital megavolt (MV) imagers is hindered by poor image quality. Novel EPID designs may help to improve quantum noise response, while also preserving the high spatial resolution of the current clinical detector. Recently investigated EPID design improvements include but are not limited to multi-layer imager (MLI) architecture, thick crystalline and amorphous scintillators, and phosphor pixilation and focusing...
September 9, 2017: Medical Physics
https://www.readbyqxmd.com/read/28881251/registration-and-fusion-quantification-of-augmented-reality-based-nasal-endoscopic-surgery
#6
Yakui Chu, Jian Yang, Shaodong Ma, Danni Ai, Wenjie Li, Hong Song, Liang Li, Duanduan Chen, Lei Chen, Yongtian Wang
This paper quantifies the registration and fusion display errors of augmented reality-based nasal endoscopic surgery (ARNES). We comparatively investigated the spatial calibration process for front-end endoscopy and redefined the accuracy level of a calibrated endoscope by using a calibration tool with improved structural reliability. We also studied how registration accuracy was combined with the number and distribution of the deployed fiducial points (FPs) for positioning and the measured registration time...
August 3, 2017: Medical Image Analysis
https://www.readbyqxmd.com/read/28874723/inducing-fluorescence-of-uranyl-acetate-as-a-dual-purpose-contrast-agent-for-correlative-light-electron-microscopy-with-nanometre-precision
#7
Maarten W Tuijtel, Aat A Mulder, Clara C Posthuma, Barbara van der Hoeven, Abraham J Koster, Montserrat Bárcena, Frank G A Faas, Thomas H Sharp
Correlative light-electron microscopy (CLEM) combines the high spatial resolution of transmission electron microscopy (TEM) with the capability of fluorescence light microscopy (FLM) to locate rare or transient cellular events within a large field of view. CLEM is therefore a powerful technique to study cellular processes. Aligning images derived from both imaging modalities is a prerequisite to correlate the two microscopy data sets, and poor alignment can limit interpretability of the data. Here, we describe how uranyl acetate, a commonly-used contrast agent for TEM, can be induced to fluoresce brightly at cryogenic temperatures (-195 °C) and imaged by cryoFLM using standard filter sets...
September 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28865127/evaluation-of-an-acute-oral-gavage-method-for-the-evaluation-of-pesticide-toxicity-in-terrestrial-amphibians
#8
Douglas J Fort, Michael B Mathis, Faith Kee, Paul Whatling, David Clerkin, Jane Staveley, Clifford Habig
Development of an acute oral toxicity test with a terrestrial-phase amphibian was considered necessary to remove the uncertainty within the field of agrochemical risk assessments. The bullfrog (Lithobates catesbeianus) was selected for use as it is a representative of the family Ranidae and historically this species has been used as an amphibian test model species. Prior to definitive study, oral gavage methods were developed with fenthion and tetraethyl pyrophosphate (TEPP). Dimethoate and malathion were subsequently tested with both male and female juvenile bullfrogs in comprehensive acute oral LD50 studies...
September 2, 2017: Environmental Toxicology and Chemistry
https://www.readbyqxmd.com/read/28862492/three-dimensional-positional-assessment-of-glenoid-fossae-and-mandibular-condyles-in-patients-with-class-ii-subdivision-malocclusion
#9
Juliana Macêdo de Mattos, Juan Martin Palomo, Antonio Carlos de Oliveira Ruellas, Paula Loureiro Cheib, Manhal Eliliwi, Bernardo Quiroga Souki
OBJECTIVES: To test the null hypotheses that the positions of the glenoid fossae and mandibular condyles are identical on the Class I and Class II sides of patients with Class II subdivision malocclusion. MATERIALS AND METHODS: Retrospective three-dimensional (3D) assessments of the positions of the glenoid fossae and mandibular condyles were made in patients with Class II malocclusion. Relative to a fiducial reference at the anterior cranial base, distances from the glenoid fossae and condyles were calculated in pretreatment cone beam computed tomographic scans of 82 patients: 41 with Class II and 41 with Class II subdivision malocclusions...
September 1, 2017: Angle Orthodontist
https://www.readbyqxmd.com/read/28854802/meet-interesting-abbreviations-in-clinical-mass-spectrometry-from-compound-classification-by-reims-to-multimodal-and-mass-spectrometry-imaging-msi
#10
D Luptáková, T Pluháček, A Palyzová, J Přichystal, J Balog, K Lemr, I Juránek, V Havlíček
This feature article discusses two modern mass spectrometry abbreviations in their clinical applications. Rapid evaporative ionization mass spectrometry (REIMS) is reported as a molecular classification tool useful for spectral features definition prior to mass spectrometry imaging (MSI). REIMS is appreciated not only as an ionization technique coupled with a surgical device but particularly as a biomarker discovery tool. For more complex understanding of pathological processes at cellular and molecular levels, the importance of multimodal approach in imaging applications is documented in the context of fiducial markers needed for hyperspectral data fusion collected by optical microscopy, elemental and molecular MSI...
2017: Acta Virologica
https://www.readbyqxmd.com/read/28846610/a-qrs-detection-and-r-point-recognition-method-for-wearable-single-lead-ecg-devices
#11
Chieh-Li Chen, Chun-Te Chuang
In the new-generation wearable Electrocardiogram (ECG) system, signal processing with low power consumption is required to transmit data when detecting dangerous rhythms and to record signals when detecting abnormal rhythms. The QRS complex is a combination of three of the graphic deflection seen on a typical ECG. This study proposes a real-time QRS detection and R point recognition method with low computational complexity while maintaining a high accuracy. The enhancement of QRS segments and restraining of P and T waves are carried out by the proposed ECG signal transformation, which also leads to the elimination of baseline wandering...
August 26, 2017: Sensors
https://www.readbyqxmd.com/read/28844603/t2-star-weighted-angiography-swan-allows-to-concomitantly-assess-the-prostate-contour-while-detecting-fiducials-before-mr-based-intensity-modulated-radiation-therapy-in-prostate-carcinoma
#12
Pierre-Antoine Dirajlal, Eva Jambon, Agnes Albat-Esquirou, Chloe Galmiche, Jean-Christophe Bernhard, Nicolas Grenier, Thibaud Haaser, François H Cornelis
PURPOSE: To evaluate the performance of T2 star-weighted angiography (SWAN) to concomitantly assess the prostate contour while detecting fiducials before magnetic resonance (MR)-based intensity-modulated radiation therapy (IMRT) in prostate carcinoma. MATERIALS AND METHODS: Forty patients (mean age: 73.1 ± 7.5 years; average Gleason score: 7 ± 1; average prostate-specific antigen: 14.7 ± 11.6 ng/mL) underwent MR and computed tomography imaging before fiducial-based IMRT...
August 22, 2017: Academic Radiology
https://www.readbyqxmd.com/read/28840171/estimation-of-subject-coregistration-errors-during-multimodal-preclinical-imaging-using-separate-instruments-origins-and-avoidance-of-artifacts
#13
Jean-Philippe Dillenseger, Christian Goetz, Amira Sayeh, Chris Healy, Isabelle Duluc, Jean-Noël Freund, André Constantinesco, Gaëlle Aubertin-Kirch, Philippe Choquet
We use high-resolution [Formula: see text] data in multiple experiments to estimate the sources of error during coregistration of images acquired on separate preclinical instruments. In combination with experiments with phantoms, we completed in vivo imaging on mice, aimed at identifying the possible sources of registration errors, caused either by transport of the animal, movement of the animal itself, or methods of coregistration. The same imaging cell was used as a holder for phantoms and animals. For all procedures, rigid coregistration was carried out using a common landmark coregistration system, placed inside the imaging cell...
July 2017: Journal of Medical Imaging
https://www.readbyqxmd.com/read/28825917/evaluation-of-an-automatic-mr-based-gold-fiducial-marker-localisation-method-for-mr-only-prostate-radiotherapy
#14
Matteo Maspero, Cornelis A T Van den Berg, Frank Zijlstra, Gonda G Sikkes, Hans C J de Boer, Gert J Meijer, Linda G W Kerkmeijer, Max A Viergever, Jan J W Lagendijk, Peter R Seevinck
An MR-only radiotherapy planning (RTP) workflow would reduce cost, radiation exposure and uncertainties introduced by CT-MRI registrations. In the case of prostate treatment, one of the remaining challenges currently withholding implementation of an RTP workflow is the MR-based localisation of intraprostatic gold Fiducial Markers (FMs), which is crucial for accurate patient positioning. Currently, MR-based FM localisation is clinically performed manually. This is sub-optimal as manual interaction increases workload...
August 21, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28812120/risk-adapted-robotic-stereotactic-body-radiation-therapy-for-inoperable-early-stage-non-small-cell-lung-cancer
#15
Susanne Temming, Martin Kocher, Erich Stoelben, Lars Hagmeyer, De-Hua Chang, Konrad Frank, Khosro Hekmat, Juergen Wolf, Wolfgang W Baus, Robert Semrau, Christian Baues, S Marnitz
PURPOSE: To evaluate efficacy and toxicity of stereotactic body radiation therapy (SBRT) with CyberKnife® (Accuray, Sunnyvale, CA, USA) in a selected cohort of primary, medically inoperable early-stage non-small cell lung cancer (NSCLC) patients. METHODS: From 2012 to 2016, 106 patients (median age 74 years, range 50-94 years) with primary NSCLC were treated with SBRT using CyberKnife®. Histologic confirmation was available in 87 patients (82%). For mediastinal staging, 92 patients (87%) underwent (18)F-fluorodeoxyglucose positron-emission tomography (18-FDG-PET) and/or endobronchial ultrasound (EBUS)-guided lymph node biopsy or mediastinoscopy...
August 15, 2017: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/28808749/bioxmark-for-high-precision-radiotherapy-in-an-orthotopic-pancreatic-tumor-mouse-model-experiences-with-a-liquid-fiducial-marker
#16
S Dobiasch, S Kampfer, R Burkhardt, D Schilling, T E Schmid, J J Wilkens, S E Combs
BACKGROUND AND PURPOSE: High-precision radiotherapy (RT) requires precise positioning, particularly with high single doses. Fiducial markers in combination with onboard imaging are excellent tools to support this. The purpose of this study is to establish a pancreatic cancer mouse model for high-precision image-guided RT (IGRT) using the liquid fiducial marker BioXmark (Nanovi, Kongens Lyngby, Denmark). METHODS: In an animal-based cancer model, different volumes of BioXmark (10-50 µl), application forms, and imaging modalities-cone-beam computer tomography (CBCT) incorporated in either the Small Animal Radiation Research Platform (SARRP) or the small-animal micro-CT Scanner (SkyScan; Bruker, Brussels, Belgium)-as well as subsequent RT with the SARRP system were analyzed to derive recommendations for BioXmark...
August 14, 2017: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/28807758/insulinoma-enucleation-after-echoendoscopic-fiducial-placement
#17
Sébastien Gaujoux, Seray Genc, Sarah Leblanc, Bertrand Dousset, Frédéric Prat
No abstract text is available yet for this article.
August 11, 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/28803447/registration-free-automatic-identification-of-gold-fiducial-markers-in-mri-target-delineation-images-for-prostate-radiotherapy
#18
Christian Gustafsson, Juha Korhonen, Emilia Persson, Adalsteinn Gunnlaugsson, Tufve Nyholm, Lars E Olsson
PURPOSE: The superior soft tissue contrast of magnetic resonance imaging (MRI) compared to computed tomography (CT) has urged the integration of MRI and elimination of CT in radiotherapy treatment (RT) for prostate. An intraprostatic gold fiducial marker (GFM) appear hyperintense on CT. On T2 weighted (T2w) MRI target delineation images the GFM appear as a small signal void similar to calcifications and post biopsy fibrosis. It can therefore be difficult to identify the markers without CT...
August 13, 2017: Medical Physics
https://www.readbyqxmd.com/read/28801767/experimental-validation-of-predicted-application-accuracies-for-computer-assisted-cas-intraoperative-navigation-with-paired-point-registration
#19
Martina Perwög, Zoltan Bardosi, Wolfgang Freysinger
PURPOSE: The target registration error (TRE) is a crucial parameter to estimate the potential usefulness of computer-assisted navigation intraoperatively. Both image-to-patient registration on base of rigid-body registration and TRE prediction methods are available for spatially isotropic and anisotropic data. This study presents a thorough validation of data obtained in an experimental operating room setting with CT images. METHODS: Optical tracking was used to register a plastic skull, an anatomic specimen, and a volunteer to their respective CT images...
August 11, 2017: International Journal of Computer Assisted Radiology and Surgery
https://www.readbyqxmd.com/read/28770553/perioperative-technical-complications-in-deep-brain-stimulation-surgeries
#20
Onur Alptekin, Ersoy Kocabicak, Felix S Gubler, Linda Ackermans, Pieter L Kubben, Yasin Temel
AIM: Deep brain stimulation (DBS) surgeries are multi-faceted and the various steps are interconnected. Since its first implementation, the method of DBS surgery has undergone changes. We have encountered several expected and also non-expected perioperative technical complications in the past seventeen years. Here, we describe the stereotactic frame, stereotactic localizer and planning station related complications and how we have managed them as much as possible. MATERIAL AND METHODS: This study is a retrospective qualitative analysis of the documented technical events encountered during DBS surgeries from 1999 onwards...
June 14, 2017: Turkish Neurosurgery
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