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https://www.readbyqxmd.com/read/29786463/hybrid-diffusion-imaging-in-mild-traumatic-brain-injury
#1
Yu-Chien Wu, Sourajit Mitra Mustafi, Jaroslaw Harezlak, Chandana Kodiweera, Laura A Flashman, Thomas McAllister
Mild traumatic brain injury (mTBI) is an important public health problem. Although conventional medical imaging techniques can detect moderate-to-severe injuries, they are relatively insensitive to mTBI. In this study, we used hybrid diffusion imaging (HYDI) to detect white-matter alterations in nineteen patients with mTBI and 23 other trauma-control patients. Within 15 days (SD=10) of brain injury, all subjects underwent magnetic-resonance HYDI and were assessed with battery of neuropsychological tests of sustained attention, memory, and executive function...
May 22, 2018: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29785584/interferon-free-therapy-in-hepatitis-c-virus-hcv-monoinfected-and-hcv-hiv-coinfected-patients-effect-on-cognitive-function-fatigue-and-mental-health
#2
Felix Kleefeld, Sophie Heller, Patrick Ingiliz, Heiko Jessen, Anders Petersen, Ute Kopp, Antje Kraft, Katrin Hahn
The efficacy and safety of interferon-free therapies for hepatitis C virus (HCV) infection have been reported. Considering the accumulating evidence for a direct central nervous system infection by HCV, we aim to evaluate the effect of direct acting antivirals (DAA) therapy on cognitive function in HCV patients. We conducted a longitudinal analysis of the cognitive performance of 22 patients (8 HCV+, 14 HCV+/HIV+) who completed neuropsychological testing at baseline and at week 12 after DAA therapy. In 20 patients, we analyzed specific attention parameters derived from an experimental testing based on the Theory of Visual Attention (TVA)...
May 21, 2018: Journal of Neurovirology
https://www.readbyqxmd.com/read/29784453/executive-summary-of-outpatient-parenteral-antimicrobial-therapy-guidelines-of-the-spanish-society-of-clinical-microbiology-and-infectious-diseases-and-the-spanish-domiciliary-hospitalisation-society
#3
Luis Eduardo López Cortés, Abel Mujal Martínez, Magdalena Fernández Martínez de Mandojana, Natalia Martín, Mercè Gil Bermejo, Joan Solà Aznar, Eulalia Villegas Bruguera, Maria José Peláez Cantero, Pilar Retamar Gentil, Miriam Delgado Vicente, Víctor José González-Ramallo, Miguel Ángel Ponce González, Manuel Mirón Rubio, M Montserrat Gómez Rodríguez de Mendarozqueta, Miguel Ángel Goenaga Sánchez, Pedro Sanroma Mendizábal, Elena Delgado Mejía, Marcos Pajarón Guerrero
Outpatient parenteral antimicrobial therapy (OPAT) programmes make it possible to start or complete intravenous antimicrobial therapy for practically any type of infection at home, provided that patient selection is appropriate for the type of OPAT programme available. Although the clinical management of infections in the home setting is comparable in many respects to that offered in conventional hospitalization (selection of antibiotics, duration of treatment, etc.), there are many aspects that are specific to this care modality...
May 18, 2018: Enfermedades Infecciosas y Microbiología Clínica
https://www.readbyqxmd.com/read/29759422/executive-summary-of-the-gesida-national-aids-plan-consensus-document-on-antiretroviral-therapy-in-adults-infected-by-the-human-immunodeficiency-virus-updated-january-2018
#4
(no author information available yet)
This update to the document on antiretroviral therapy (ART) in adults, which has been prepared jointly by GeSIDA and the Spanish National AIDS Plan for the last two decades, supersedes the document published in 2017.1 The update provides physicians treating HIV-1-infected adults with evidence-based recommendations to guide their therapeutic decisions. The main difference with respect to the previous document concerns recommended initial ART regimens, only three of which are maintained as preferential. All three include dolutegravir or raltegravir, together with emtricitabine/tenofovir alafenamide or abacavir/lamivudine...
May 11, 2018: Enfermedades Infecciosas y Microbiología Clínica
https://www.readbyqxmd.com/read/29743246/correction-to-2017-acc-aha-aapa-abc-acpm-ags-apha-ash-aspc-nma-pcna-guideline-for-the-prevention-detection-evaluation-and-management-of-high-blood-pressure-in-adults-executive-summary-a-report-of-the-american-college-of-cardiology-american-heart-association
#5
https://www.readbyqxmd.com/read/29737410/executive-summary-of-the-clinical-guidelines-of-pharmacotherapy-for-neuropathic-pain-second-edition-by-the-japanese-society-of-pain-clinicians
#6
REVIEW
Masahiko Sumitani, Tetsuya Sakai, Yoichi Matsuda, Hiroaki Abe, Shigeki Yamaguchi, Toyoshi Hosokawa, Sei Fukui
Neuropathic pain has a substantial effect on quality of life (QOL). The Japanese Society of Pain Clinicians (JSPC) has developed clinical guidelines of pharmacotherapy for neuropathic pain. These guidelines offer clarity on recommendations based on both the most recent scientific evidence and expert opinions. Understanding the concept, disease entity, and burden of neuropathic pain, as well as its screening and diagnosis are important steps before starting pharmacotherapy. As well as other guidelines, the guidelines propose several lines of pharmacotherapies in a step-wise manner...
May 8, 2018: Journal of Anesthesia
https://www.readbyqxmd.com/read/29733006/barriers-and-opportunities-related-to-extracorporeal-cardiopulmonary-resuscitation-for-out-of-hospital-cardiac-arrest-in-canada-a-report-from-the-first-meeting-of-the-canadian-ecpr-research-working-group
#7
Steven C Brooks, Sam D Shemie, Sylvia Torrance, Laura Hornby, Clay Gillrie, Brian Grunau, A Dave Nagpal, Andrew Baker, Jim Christenson, John Gill, Laurie Morrison
For a French translation of the executive summary, please see the Supplementary Material at DOI: 10.107/cem.2017.429.
May 7, 2018: CJEM
https://www.readbyqxmd.com/read/29731212/no-292-abnormal-uterine-bleeding-in-pre-menopausal-women
#8
Sukhbir Singh, Carolyn Best, Sheila Dunn, Nicholas Leyland, Wendy Lynn Wolfman
BACKGROUND: Abnormal uterine bleeding is the direct cause of a significant health care burden for women, their families, and society as a whole. Up to 30% of women will seek medical assistance for this problem during their reproductive years. This guideline replaces previous clinical guidelines on the topic and is aimed to enable health care providers with the tools to provide the latest evidence-based care in the diagnosis and the medical and surgical management of this common problem...
May 2018: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
https://www.readbyqxmd.com/read/29727626/effects-of-prefrontal-tdcs-on-executive-function-methodological-considerations-revealed-by-meta-analysis
#9
Michael J Imburgio, Joseph M Orr
A meta-analysis of studies using single-session transcranial direct current stimulation (tDCS) to target the dorsolateral prefrontal cortex (DLPFC) was undertaken to examine the effect of stimulation on executive function (EF) in healthy samples. 27 studies were included in analyses, yielding 71 effect sizes. The most relevant measure for each task was determined a priori and used to calculate Hedge's g. Methodological characteristics of each study were examined individually as potential moderators of effect size...
May 1, 2018: Neuropsychologia
https://www.readbyqxmd.com/read/29720875/patient-engagement-in-type-2-diabetes-mellitus-research-what-patients-want
#10
Kristina F Simacek, Tanya Nelson, Mignon Miller-Baldi, Susan C Bolge
Background: As patients are the ultimate stakeholder in their health, their perspectives should be included along with researchers, providers, and funders of research design, execution, and interpretation. Despite the high prevalence of type 2 diabetes mellitus (T2DM), patients are rarely directly included in these decisions. Purpose: We sought to determine areas of research most important to patients with T2DM, identify ways through which patients with T2DM want to engage in research, and evaluate online patient research networks as a source for obtaining patient perspectives on research engagement...
2018: Patient Preference and Adherence
https://www.readbyqxmd.com/read/29718103/a-powerful-approach-reveals-numerous-expression-quantitative-trait-haplotypes-in-multiple-tissues
#11
Dingge Ying, Mulin Jun Li, Pak Chung Sham, Miaoxin Li
Motivation: Recently many studies showed single nucleotide polymorphisms (SNPs) affect gene expression and contribute to development of complex traits/diseases in a tissue context-dependent manner. However, little is known about haplotype's influence on gene expression and complex traits, which reflects the interaction effect between SNPs. Results: In the present study, we firstly proposed a regulatory region guided eQTL haplotype association analysis approach, and then systematically investigate the expression quantitative trait loci (eQTL) haplotypes in 20 different tissues by the approach...
April 26, 2018: Bioinformatics
https://www.readbyqxmd.com/read/29714591/investigation-of-the-study-characteristics-affecting-clinical-trial-quality-using-the-protocol-deviations-leading-to-exclusion-of-subjects-from-the-per-protocol-set-data-in-studies-for-new-drug-application-a-retrospective-analysis
#12
Norihito Kohara, Masayuki Kaneko, Mamoru Narukawa
BACKGROUND: The concept of the risk-based approach has been introduced as an effort to secure the quality of clinical trials. In the risk-based approach, identification and evaluation of risk in advance are considered important. For recently completed clinical trials, we investigated the relationship between study characteristics and protocol deviations leading to the exclusion of subjects from Per Protocol Set (PPS) efficacy analysis. METHODS: New drugs approved in Japan in the fiscal year 2014-2015 were targeted in the research...
January 1, 2018: Therapeutic Innovation & Regulatory Science
https://www.readbyqxmd.com/read/29701548/global-neurosurgery-the-current-capacity-and-deficit-in-the-provision-of-essential-neurosurgical-care-executive-summary-of-the-global-neurosurgery-initiative-at-the-program-in-global-surgery-and-social-change
#13
Michael C Dewan, Abbas Rattani, Graham Fieggen, Miguel A Arraez, Franco Servadei, Frederick A Boop, Walter D Johnson, Benjamin C Warf, Kee B Park
OBJECTIVE Worldwide disparities in the provision of surgical care result in otherwise preventable disability and death. There is a growing need to quantify the global burden of neurosurgical disease specifically, and the workforce necessary to meet this demand. METHODS Results from a multinational collaborative effort to describe the global neurosurgical burden were aggregated and summarized. First, country registries, third-party modeled data, and meta-analyzed published data were combined to generate incidence and volume figures for 10 common neurosurgical conditions...
April 27, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29701527/executive-summary-of-the-merck-animal-health-veterinary-wellbeing-study
#14
John O Volk, Ulrich Schimmack, Elizabeth B Strand, Linda K Lord, Colin W Siren
No abstract text is available yet for this article.
May 15, 2018: Journal of the American Veterinary Medical Association
https://www.readbyqxmd.com/read/29698290/wound-ostomy-and-continence-nursing-scope-and-standards-of-practice-2nd-edition-an-executive-summary
#15
(no author information available yet)
Wound, ostomy, and continence (WOC) nursing was recognized as a nursing specialty by the American Nurses Association in February 2010, and the Society published the original scope and standards of WOC nursing practice in May 2010. The Wound, Ostomy, and Continence Nursing: Scope and Standards of Practice, 2nd Edition is the definitive resource promoting excellence in professional practice, quality care, and improved patient outcomes in WOC specialty practice. It can be used to articulate the value of WOC nurses to administrators, legislators, payers, patients, and others...
April 25, 2018: Journal of Wound, Ostomy, and Continence Nursing
https://www.readbyqxmd.com/read/29685846/standardization-of-laboratory-lipid-profile-assessment-a-call-for-action-with-a-special-focus-on-the-2016-esc-eas-dyslipidemia-guidelines-executive-summary-a-consensus-endorsed-by-the-cardiovascular-risk-and-prevention-group-of-the-portuguese-internal-medicine
#16
Pedro Marques da Silva, João Sequeira Duarte, Pedro von Hafe, Victor Gil, Jorge Nunes de Oliveira, Germano de Sousa
Even with improvements in lifestyle interventions, better control of cardiovascular (CV) risk factors, and improvements in CV outcomes, cardiovascular disease (CVD) remains the leading cause of morbidity and mortality in Portugal and Europe. Atherogenic dyslipidemias, particularly hypercholesterolemia, have a crucial causal role in the development of atherosclerotic CVD. The clinical approach to a patient with dyslipidemia requires an accurate diagnosis, based on harmonized and standardized lipid and lipoprotein laboratory assessments...
April 20, 2018: Portuguese Journal of Cardiology: An Official Journal of the Portuguese Society of Cardiology
https://www.readbyqxmd.com/read/29668110/phenylbutyl-isoselenocyanate-induces-reactive-oxygen-species-to-inhibit-androgen-receptor-and-to-initiate-p53-mediated-apoptosis-in-lncap-prostate-cancer-cells
#17
Wei Wu, Deepkamal Karelia, Kartick Pramanik, Shantu G Amin, Arun K Sharma, Cheng Jiang, Junxuan Lu
Previous studies have established the in vivo bioavailability and efficacious dosages of phenylbutyl isoselenocyanate (ISC-4), a selenium-substituted isothiocyanate, against mouse xenograft models of human melanoma and colorectal cancer. To explore its potential attributes against prostate cancer, we treated human LNCaP prostate cancer cells with ISC-4 and examined their apoptosis responses, and interrogated the signaling mechanisms through pharmacological and siRNA knockdown approaches. Our results show that ISC-4 was more potent at inducing apoptosis than its sulfur analog phenylbutyl isothiocyanate (PBITC) without suppressing protein kinase AKT Ser473 phosphorylation...
April 18, 2018: Molecular Carcinogenesis
https://www.readbyqxmd.com/read/29643258/prevalence-of-poststroke-neurocognitive-disorders-using-national-institute-of-neurological-disorders-and-stroke-canadian-stroke-network-vascog-criteria-vascular-behavioral-and-cognitive-disorders-and-optimized-criteria-of-cognitive-deficit
#18
Mélanie Barbay, Hervé Taillia, Claudine Nédélec-Ciceri, Flavie Bompaire, Camille Bonnin, Jérôme Varvat, Françoise Grangette, Momar Diouf, Emmanuel Wiener, Jean-Louis Mas, Martine Roussel, Olivier Godefroy
BACKGROUND AND PURPOSE: The prevalence of poststroke neurocognitive disorder (NCD) has yet to be accurately determined. The primary objective of the present study was to optimize operationalization of the criterion for NCD by using an external validity criterion. METHODS: The GRECOG-VASC cohort (Groupe de Réflexion pour l'Évaluation Cognitive Vasculaire) of 404 stroke patients with cerebral infarct (91.3%) or hemorrhage (18.7%) was assessed 6 months poststroke and 1003 healthy controls, with the National Institute of Neurological Disorders and Stroke-Canadian Stroke Network standardized battery...
April 11, 2018: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/29625752/linear-magnetic-clutch-to-automatically-control-torque-output
#19
Nan-Chyuan Tsai, Chi-Ting Yeh, Hsin-Lin Chiu
A novel eddy-current Magnetic Clutch (MC) unit with its torque-adjustable mechanism is proposed by this research. As to mechanical structure, the MC unit is mainly constituted by a squirrel-cage inner rotor and a magnet-embedded outer rotor. The transmitted output torque can be adjusted by either the Overlapped Length (OL) or the relative angular velocity between outer rotor and inner rotor. Firstly, the mathematical model of the MC system is developed. Secondly, the features and characterization of the MC unit are explored by intensive experiments under various overlapped length and relative rotational speed between inner rotor and outer rotor...
April 3, 2018: ISA Transactions
https://www.readbyqxmd.com/read/29574144/consensus-paper-on-the-executive-summary-of-the-international-conference-on-mediterranean-diet-and-health-a-lifelong-approach-an-italian-initiative-supported-by-the-mediterranean-diet-foundation-and-the-menarini-foundation
#20
Virginia Boccardi, Riccardo Calvani, Federica Limongi, Anna Marseglia, Alexandra Mason, Marianna Noale, Domenico Rogoli, Nicola Veronese, Gaetano Crepaldi, Stefania Maggi
The Mediterranean Diet Foundation, in collaboration with the International Menarini Foundation, organized the "International Conference on Mediterranean Diet and Health: A Lifelong Approach." The Conference was held in Ostuni (Puglia, Italy) from March 30 to April 1, 2017. The event received the endorsement of the American Federation for Aging Research, the Research Consortium "Luigi Amaducci," the European Nutrition for Health Alliance, the European Union Geriatric Medicine Society, the Clinical Section of the International Association of Gerontology and Geriatrics-European Region, the National Research Council Research Project on Aging, the Italian Society of Gerontology and Geriatrics, and the Italian Society of Clinical Nutrition and Metabolism...
February 8, 2018: Nutrition
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