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https://www.readbyqxmd.com/read/28327053/predictive-parameters-for-imatinib-failure-in-patients-with-chronic-myeloid-leukemia
#1
Danijela Lekovic, Mirjana Gotic, Natasa Milic, Biljana Zivojinovic, Jelica Jovanovic, Natasa Colovic, Violeta Milosevic, Andrija Bogdanovic
OBJECTIVE: Until recently, imatinib was the standard first-line treatment in chronic myeloid leukemia (CML). The inclusion of nilotinib and dasatinib as first-line options in CML raised a debate on treatment selection. The aim of our study was to analyze predictive parameters for imatinib response as the first-line treatment of CML patients. METHODS: The study included 168 consecutive patients with chronic phase Philadelphia-positive CML who were diagnosed and treated with Imatinib 400 mg once daily at a single university hospital...
March 22, 2017: Hematology (Amsterdam, Netherlands)
https://www.readbyqxmd.com/read/28299542/understanding-and-improving-knowledge-of-cancer-survivorship-care-among-college-providers
#2
Alexandra M Psihogios, Helen Pauly-Hubbard, Lisa Schwartz, Jill P Ginsberg, Wendy Hobbie, Dava Szalda
This study aimed to assess college providers' basic knowledge of the health risks of young adult cancer survivors (YAS) and related care guidelines and to determine whether an educational in-service is an effective platform for increasing college health providers' knowledge about survivorship care at a large university health center. During phase 1, staff from college health centers and office of disabilities in the Philadelphia area (n = 40 staff members from 24 colleges/universities) completed a needs assessment on their experiences with YAS and preferences for education and care coordination...
March 15, 2017: Journal of Cancer Education: the Official Journal of the American Association for Cancer Education
https://www.readbyqxmd.com/read/28278315/biochemical-effects-of-exercise-on-a-fasciocutaneous-flap-in-a-rat-model
#3
Edita Aksamitiene, Adam L Baker, Sudeep Roy, Salini Hota, Li-Hui Zhang, Julianna Rodin, Kealan Hobelmann, Jan B Hoek, Edmund A Pribitkin
Importance: An overwhelming amount of data suggest that cardiovascular exercise has a positive effect on the mind and body, although the precise mechanism is not always clear. Objective: To assess the clinical and biochemical effects of voluntary cardiovascular exercise on pedicled flaps in a rodent model. Design, Setting, and Participants: Eighteen adult Sprague-Dawley male rats were randomized into a resting animal group (RAG) (n=9) and an exercise animal group (EAG) (n=9) for 14 days (July 23, 2013, through July 30, 2013)...
March 9, 2017: JAMA Facial Plastic Surgery
https://www.readbyqxmd.com/read/28257409/a-case-study-of-the-philadelphia-sugar-sweetened-beverage-tax-policymaking-process-implications-for-policy-development-and-advocacy
#4
Jonathan Purtle, Brent Langellier, Félice Lê-Scherban
CONTEXT: Policymakers are increasingly proposing sugar-sweetened beverage (SSB) taxes as an evidence-based strategy to reduce chronic disease risk; and local health departments (LHDs) are well-positioned to play a role in SSB policy development and advocacy. However, most SSB tax proposals fail to become law and limited empiric guidance exists to inform advocacy efforts. In June 2016, Philadelphia, Pennsylvania, passed an SSB tax. OBJECTIVE: To identify features of the Philadelphia SSB tax policymaking process that contributed to the proposal's passage...
March 1, 2017: Journal of Public Health Management and Practice: JPHMP
https://www.readbyqxmd.com/read/28238705/an-informed-consent-program-enhances-surgery-resident-education
#5
Sarah E Koller, Ryan F Moore, Michael B Goldberg, Jeanette Zhang, Daohai Yu, Charles B Conklin, Richard E Milner, Amy J Goldberg
OBJECTIVE: First-year residents often obtain informed consent from patients. However, they typically receive no formal training in this area before residency. We wished to determine whether an educational program would improve residents' comfort with this process. DESIGN: Our institution created an informed consent educational program, which included a didactic component, a role-play about informed consent, and a simulation exercise using standardized patients. Residents completed surveys before and after the intervention, and responses to survey questions were compared using the signed-rank test...
February 23, 2017: Journal of Surgical Education
https://www.readbyqxmd.com/read/28159490/chemohormonal-therapy-in-metastatic-hormone-sensitive-prostate-cancer-sweeney-cj-chen-yh-carducci-m-liu-g-jarrard-df-eisenberger-m-wong-yn-hahn-n-kohli-m-cooney-mm-dreicer-r-vogelzang-nj-picus-j-shevrin-d-hussain-m-garcia-ja-dipaola-rs-department-of-medicine
#6
Eggener Scott
BACKGROUND: Androgen deprivation therapy (ADT) has been the backbone of treatment for metastatic prostate cancer since the 1940s. We assessed whether concomitant treatment with ADT plus docetaxel would result in longer overall survival than that with ADT alone. METHODS: We assigned men with metastatic, hormone-sensitive prostate cancer to receive either ADT plus docetaxel (at a dose of 75mg per square meter of body-surface area every 3wk for 6 cycles) or ADT alone...
March 2017: Urologic Oncology
https://www.readbyqxmd.com/read/28148316/design-and-initial-results-of-a-programme-for-routine-standardised-longitudinal-follow-up-after-congenital-heart-surgery
#7
Sara K Pasquali, Chitra Ravishankar, Jennifer C Romano, Kristin Kane, Suzanne Viers, Andrea Kennedy, Nancy Burnham, Ray Lowery, Karen Uzark, Lauren Retzloff, Jonathon J Rome, Joseph W Rossano, John R Charpie, Thomas L Spray, Michael G Gaies, Richard G Ohye, J William Gaynor
BACKGROUND: With improvements in early survival following congenital heart surgery, it has become increasingly important to understand longer-term outcomes; however, routine collection of these data is challenging and remains very limited. We describe the development and initial results of a collaborative programme incorporating standardised longitudinal follow-up into usual care at the Children's Hospital of Philadelphia (CHOP) and University of Michigan (UM). METHODS: We included children undergoing benchmark operations of the Society of Thoracic Surgeons...
December 2016: Cardiology in the Young
https://www.readbyqxmd.com/read/28141963/following-the-yellow-brick-road
#8
Charles H Calisher
Charles Calisher was fascinated by microorganisms from the time he was in high school. He attended Stuyvesant High School in New York City, Philadelphia College of Pharmacy and Science (now University of the Sciences) (BS), then University of Notre Dame in South Bend, Indiana (MS), and finally Georgetown University, in Washington, DC (PhD), the latter while employed at a commercial biological house. He was hired by the US Communicable Disease Center (now the Centers for Disease Control and Prevention) in Atlanta, Georgia, was transferred to its Fort Collins laboratories in 1973, and retired from there in 1992...
January 31, 2017: Annual Review of Entomology
https://www.readbyqxmd.com/read/28056115/a-tiered-approach-to-retinopathy-of-prematurity-screening-tarp-using-a-weight-gain-predictive-model-and-a-telemedicine-system
#9
Jaclyn Gurwin, Lauren A Tomlinson, Graham E Quinn, Gui-Shuang Ying, Agnieshka Baumritter, Gil Binenbaum
Importance: The Telemedicine Approaches to Evaluating Acute-Phase Retinopathy of Prematurity (e-ROP) Study telemedicine system of remote fundus image grading and The Children's Hospital of Philadelphia Retinopathy of Prematurity (CHOP-ROP) postnatal weight gain predictive model are 2 approaches for improving ROP screening efficiency. Current screening has low specificity for severe ROP. Objective: To describe a tiered approach to ROP screening (TARP) for identifying children who develop severe ROP using telemedicine and a predictive model synergistically...
January 5, 2017: JAMA Ophthalmology
https://www.readbyqxmd.com/read/27988194/hyper-cvad-compared-with-bfm-like-chemotherapy-for-the-treatment-of-adult-acute-lymphoblastic-leukemia-a-retrospective-single-center-analysis
#10
Jean El-Cheikh, Imane El Dika, Radwan Massoud, Maya Charafeddine, Rami Mahfouz, Mohamed A Kharfan-Dabaja, Ali Bazarbachi
BACKGROUND: Several induction regimens have been developed for treatment of adult patients with acute lymphoblastic leukemia (ALL). However, only a few prospective randomized trials have directly compared these regimens. PATIENTS AND METHODS: In this report, we retrospectively evaluated the outcome of 62 adult ALL patients treated with either hyper-CVAD (hyper fractionated cyclophosphamide, vincristine, doxorubicin, and dexamethasone; n = 38) or a BFM (Berlin-Frankfurt-Munster)-like regimen (n = 24) between November 2000 and January 2016 at the American university of Beirut Medical Center in Lebanon...
March 2017: Clinical Lymphoma, Myeloma & Leukemia
https://www.readbyqxmd.com/read/27925606/increasing-awareness-and-acceptance-through-mindfulness-and-somatic-education-movements
#11
Paulo Vicente Bloise, Mário César Rezende Andrade, Hans Machado, Sérgio Baxter Andreoli
Context • The main feature of mindfulness-based interventions (MBI) is the encouragement of present moment awareness and of self-regulation, which are associated with health benefits. Meditating with the body in movement has been referred to as one of the most accessible ways of reaching such awareness. An MBI program, Mindfulness and Movements of Integration (MMI), has the same structure as mindfulness-based stress reduction (MBSR) but puts more emphasis on the body and uses somatic education (SE) movements instead of yoga postures...
October 2016: Advances in Mind-body Medicine
https://www.readbyqxmd.com/read/27924188/-learning-from-yellowstone-commencement-address-to-philadelphia-university-physician-assistants-graduating-class
#12
EDITORIAL
David B Nash
No abstract text is available yet for this article.
October 2016: American Health & Drug Benefits
https://www.readbyqxmd.com/read/27921214/external-validity-of-the-chiari-severity-index-and-outcomes-among-pediatric-chiari-i-patients-treated-with-intra-or-extra-dural-decompression
#13
Jared M Pisapia, Maxwell B Merkow, Danielle Brewington, Rosemary E Henn, Leslie N Sutton, Phillip B Storm, Gregory G Heuer
INTRODUCTION: Chiari malformation type-1 (CM-1) may be treated by intradural (ID) or extradural (ED) posterior fossa decompression, although the optimal approach is debated. The Chiari Severity Index (CSI) is a pre-operative metric to predict patient-defined improvement after CM-1 surgery. In this study, we evaluate the results of ID versus ED decompression and assess the external validity of the CSI. METHODS: We performed a retrospective cohort study of pediatric CM-1 patients undergoing decompression at a single academic children's hospital...
December 5, 2016: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/27917092/colorectal-cancer-screening-navigation-for-the-underserved-experience-of-an-urban-program
#14
Alicia Lamanna, Heather Sheaffer, Carmen Guerra, Michael Kochman
Colorectal cancer is the third leading cause of cancer deaths in the United States. Although colorectal cancer screenings are effective and recommended by all clinical practice guidelines, only 65.7% of adults ages 50 to 75 years are screened. Colorectal cancer screening is disproportionately underutilized in inner city populations. In 2011, the University of Pennsylvania Health System created a navigation program to specifically address poor colorectal cancer screening rates and increase access to colorectal cancer screening colonoscopies for patients in the underserved areas of West, South, and Southwest Philadelphia...
September 2016: Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/27902574/analysis-of-hospital-readmission-patterns-in-medicare-fee-for-service-and-medicare-advantage-beneficiaries
#15
Joobong June Park Oh
PURPOSE OF STUDY: The study was conducted to examine the hospital readmission patterns of two groups of Medicare beneficiaries-those covered by traditional Medicare (Medicare fee-for-service [FFS]) and those enrolled in a Medicare risk plan (Medicare Advantage [MA])-and to determine the characteristics that significantly increase the likelihood of multiple hospital readmissions. PRIMARY PRACTICE SETTING: The study setting is the Hospital of the University of Pennsylvania (HUP) located in Philadelphia, PA...
January 2017: Professional Case Management
https://www.readbyqxmd.com/read/27834243/beyond-books-public-libraries-as-partners-for-population-health
#16
Anna U Morgan, Roxanne Dupuis, Bernadette D'Alonzo, Andria Johnson, Amy Graves, Kiahana L Brooks, Autumn McClintock, Heather Klusaritz, Hillary Bogner, Judith A Long, David Grande, Carolyn C Cannuscio
Public libraries are not usually included in discussions about improving population health. They are, however, well positioned to be partners in building a culture of health through programming that addresses the social determinants of health. The Healthy Library Initiative, a partnership between the University of Pennsylvania and the Free Library of Philadelphia (the public library system that serves the city), has undertaken such efforts in Philadelphia. In this article we report findings from an assessment of how ten highly subscribed programs address the social determinants of health, as well as results of interviews with community residents and library staff...
November 1, 2016: Health Affairs
https://www.readbyqxmd.com/read/27692076/totally-endoscopic-robotic-mitral-valve-surgery
#17
James R McCarthy, T Sloane Guy
Mitral valve dysfunction can seriously impair patients' lives and may require valve repair or replacement. Surgery can be performed using techniques including sternotomy; right thoracotomy with or without robot assistance; and the totally endoscopic robotic technique, which requires percutaneous techniques, femoral cannulation, and endovascular aortic cross-clamping. The totally endoscopic robotic technique has been facilitated by minimally invasive surgical techniques, the evolution of endoscopic techniques, and the development of surgical robots...
October 2016: AORN Journal
https://www.readbyqxmd.com/read/27623276/anterior-leaflet-augmentation-with-cormatrix-porcine-extracellular-matrix-in-twenty-five-patients-unexpected-patch-failures-and-histologic-analysis
#18
Thomas M Kelley, Mohammed Kashem, He Wang, James McCarthy, Nels D Carroll, G William Moser, T Sloane Guy
BACKGROUND: This study reported on the treatment of Carpentier type IIIa and type IIIb mitral regurgitation (MR) with a large patch anterior mitral valve leaflet augmentation technique using CorMatrix (CorMatrix Cardiovascular Inc, Alpharetta, GA) extracellular matrix (ECM). METHODS: A single-site chart review was conducted on patients who underwent anterior leaflet augmentation performed with the Da Vinci surgical robot (Intuitive Surgical, Sunnyvale, CA) or through a median sternotomy...
January 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/27617191/support-or-competition-how-online-social-networks-increase-physical-activity-a-randomized-controlled-trial
#19
Jingwen Zhang, Devon Brackbill, Sijia Yang, Joshua Becker, Natalie Herbert, Damon Centola
To identify what features of online social networks can increase physical activity, we conducted a 4-arm randomized controlled trial in 2014 in Philadelphia, PA. Students (n = 790, mean age = 25.2) at an university were randomly assigned to one of four conditions composed of either supportive or competitive relationships and either with individual or team incentives for attending exercise classes. The social comparison condition placed participants into 6-person competitive networks with individual incentives...
December 2016: Preventive Medicine Reports
https://www.readbyqxmd.com/read/27581701/culture-and-ptsd-trauma-in-global-and-historical-perspectiveedited-by-devon-e-hinton-and-byron-j-good-philadelphia-university-of-pennsylvania-press-2015-440-pp-75-00-hardcover
#20
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