keyword
https://read.qxmd.com/read/38533720/tumor-associated-macrophages-as-key-contributors-and-targets-in-current-and-future-therapies-for-melanoma
#1
REVIEW
Shabana Habib, Gabriel Osborn, Zena Willsmore, Min Waye Chew, Sophie Jakubow, Amanda Fitzpatrick, Yin Wu, Khushboo Sinha, Hawys Lloyd-Hughes, Jenny L C Geh, Alastair D MacKenzie-Ross, Sean Whittaker, Victoria Sanz-Moreno, Katie E Lacy, Sophia N Karagiannis, Rebecca Adams
INTRODUCTION: Despite the success of immunotherapies for melanoma in recent years, there remains a significant proportion of patients who do not yet derive benefit from available treatments. Immunotherapies currently licensed for clinical use target the adaptive immune system, focussing on Tcell interactions and functions. However, the most prevalent immune cells within the tumor microenvironment (TME) of melanoma are macrophages, a diverse immune cell subset displaying high plasticity, to which no current therapies are yet directly targeted...
March 27, 2024: Expert Review of Clinical Immunology
https://read.qxmd.com/read/38531202/dehydrozaluzanin-c-derivative-protects-septic-mice-by-alleviating-over-activated-inflammatory-response-and-promoting-the-phagocytosis-of-macrophages
#2
JOURNAL ARTICLE
Ying-Xiang Zou, Tian-Nan Xiang, Li-Rong Xu, Huan Zhang, Yu-He Ma, Lu Zhang, Chun-Xian Zhou, Xiao Wu, Qi-Lin Huang, Biao Lei, Jing-Wen Mu, Xiang-Yang Qin, Xin Jiang, Yue-Juan Zheng
Host-directed therapy (HDT) is a new adjuvant strategy that interfere with host cell factors that are required by a pathogen for replication or persistence. In this study, we assessed the effect of dehydrozaluzanin C-derivative (DHZD), a modified compound from dehydrozaluzanin C (DHZC), as a potential HDT agent for severe infection. LPS-induced septic mouse model and Carbapenem resistant Klebsiella pneumoniae (CRKP) infection mouse model was used for testing in vivo. RAW264.7 cells, mouse primary macrophages, and DCs were used for in vitro experiments...
March 25, 2024: International Immunopharmacology
https://read.qxmd.com/read/38531201/cirp-increases-foxp3-regulatory-t-cells-and-inhibits-development-of-th17-cells-by-enhancing-tlr4-il-2-signaling-in-the-late-phase-of-sepsis
#3
JOURNAL ARTICLE
Zongsheng Wu, Xu Liu, Wei Huang, Jing Chen, Songli Li, Jie Chao, Jianfeng Xie, Ling Liu, Yi Yang, Xiaojing Wu, Haibo Qiu
BACKGROUND: T helper (Th) cell imbalances have been associated with the pathophysiology of sepsis, including the Th1/Th2 and Th17/T regulatory cells (Treg) paradigms. Cold-inducible RNA-binding protein (CIRP), a novel damage-associated molecular pattern (DAMP) was reported that could induce T cell activation, and skew CD4+ T cells towards a Th1 profile. However, the effect and underlying mechanisms of CIRP on Th17/Treg differentiation in sepsis still remains unknown. METHODS: A prospective exploratory study including patients with sepsis was conducted...
March 25, 2024: International Immunopharmacology
https://read.qxmd.com/read/38531200/ischemia-inhibited-ferric-chelate-reductase-1-improves-ferroptosis-mediated-intestinal-ischemia-injury-via-hippo-signaling
#4
JOURNAL ARTICLE
Pengzhen Liang, Wei Xie, Xing Wang, Zhaohui Du, Chuanming Zheng, Hongchang Zhao, Zhenjie Wang, Zhong Ji
The precise mechanism of ferroptosis as a regulatory cell death in intestinal ischemia injury induced by vascular intestinal obstruction (Vio) remains to be elucidated. Here, we evaluated iron levels, glutathione peroxidase 4 (GPX4) and Acyl-CoA synthetase long-chain family member 4 (ACSL4) changes after intestinal ischemia injury to validate ferroptosis. As an enzyme for Fe3+ reduction to Fe2+ , Ferric Chelate Reductase 1 (FRRS1) is involved in the electron transport chain and the tricarboxylic acid (TCA) cycle in mitochondria...
March 25, 2024: International Immunopharmacology
https://read.qxmd.com/read/38531171/efficacy-and-safety-of-mesenchymal-stem-cell-derived-microvesicles-in-mouse-inflammatory-arthritis
#5
JOURNAL ARTICLE
Shixiong Wei, Chenyang Lu, Sujia Li, Qiuping Zhang, Ruijuan Cheng, ShuYue Pan, QiuHong Wu, Xueting Zhao, Xinping Tian, Xiaofeng Zeng, Yi Liu
OBJECTIVE: To determine the effective and safe intravenous doses of mesenchymal stem cells (MSCs)-derived microvesicles (MVs) and to elucidate the possible causes of death in mice receiving high-dose MVs. METHODS: MVs were isolated from human MSCs by gradient centrifugation. Mice with collagen-induced arthritis were treated with different doses of intravenous MVs or MSCs. Arthritis severity, white blood cell count, and serum C-reactive protein levels were measured...
March 25, 2024: International Immunopharmacology
https://read.qxmd.com/read/38529710/sq-sublingual-immunotherapy-tablets-for-children-with-allergic-rhinitis-a-review-of-phase-three-trials
#6
REVIEW
Péter Csonka, Eckard Hamelmann, Mirjana Turkalj, Graham Roberts, Douglas P Mack
AIM: To provide paediatricians with a summary of efficacy and safety of SQ sublingual immunotherapy (SLIT) tablets from phase three, randomised, double-blind, placebo-controlled trials in children and adolescents with allergic rhinitis or rhinoconjunctivitis, with and without asthma. METHODS: PubMed searches were conducted and unpublished data were included if necessary. RESULTS: Of the 93 publications, 12 were identified reporting 10 trials...
March 26, 2024: Acta Paediatrica
https://read.qxmd.com/read/38528707/psychological-support-needs-for-children-with-food-allergy-and-their-families-a-systematic-review
#7
REVIEW
Rebecca C Knibb, Christina J Jones, Linda J Herbert, Cassandra Screti
This systematic review aimed to review the evidence for psychological support for children with food allergies and their families, identify effective psychological interventions, and highlight the support needs for this group. A systematic search was undertaken across six databases (up to October 2023). Articles were checked by three reviewers for inclusion. Study data were extracted, and quality was assessed using the Mixed Methods Appraisal Tool. A narrative synthesis was undertaken. A total of 11 papers were included (n = 838 participants)...
March 2024: Pediatric Allergy and Immunology
https://read.qxmd.com/read/38527402/up-regulation-of-hsp90%C3%AE-in-hdm-induced-asthma-causes-pyroptosis-of-airway-epithelial-cells-by-activating-the-cgas-sting-er-stress-pathway
#8
JOURNAL ARTICLE
Haohua Huang, Yujie Qiao, Lanhe Chu, Cuiping Ye, Lishan Lin, Hua Liao, Xiaojing Meng, Fei Zou, Haijin Zhao, Mengchen Zou, Shaoxi Cai, Hangming Dong
Heat Shock protein 90 α (HSP90α), an main subtype of chaperone protein HSP90, involves important biological functions such as DNA damage repair, protein modification, innate immunity. However, the potential role of HSP90α in asthma occurrence and development is still unclear. This study aimed to elucidate the underlying mechanism of HSP90α in asthma by focusing on the cGAS-STING-Endoplasmic Reticulum stress pathway in inflammatory airway epithelial cell death (i.e., pyroptosis; inflammatory cell death)...
March 24, 2024: International Immunopharmacology
https://read.qxmd.com/read/38527401/the-role-of-fpr2-mediated-ferroptosis-in-formyl-peptide-induced-acute-lung-injury-against-endothelial-barrier-damage-and-protective-effect-of-the-mitochondria-derived-peptide-mots-c
#9
JOURNAL ARTICLE
Ziang Wen, Jidan Fan, Faliang Zhan, Xiaopei Li, Ben Li, Peng Lu, Xin Yao, Zihao Shen, Zhaoyang Liu, Chufan Wang, Xiangyu Li, Wanjun Jin, Xiao Zhang, Yuanpu Qi, Xiaowei Wang, Meijuan Song
BACKGROUND: Acute lung injury (ALI) has garnered significant attention in the field of respiratory and critical care due to its high mortality and morbidity, and limited treatment options. The role of the endothelial barrier in the development of ALI is crucial. Several bacterial pathogenic factors, including the bacteria-derived formyl peptide (fMLP), have been implicated in damaging the endothelial barrier and initiating ALI. However, the mechanism by which fMLP causes ALI remains unclear...
March 24, 2024: International Immunopharmacology
https://read.qxmd.com/read/38526693/from-skin-to-solution-exploring-epicutaneous-immunotherapy-for-peanut-allergy-a-systematic-review-and-meta-analysis
#10
REVIEW
Umm E Salma Shabbar Banatwala, Muhammad Moiz Nasir, Reema Javed, Areeba Ahmed, Syed Ali Farhan, Ali Ajam
Peanut allergy is a leading cause of severe food reactions. This meta-analysis evaluates the efficacy and safety of epicutaneous immunotherapy (EPIT) compared to placebo for peanut-allergic individuals. After prospectively registering on PROSPERO, we searched three databases (PubMed, Google Scholar, and Cochrane CENTRAL) and 2 trial registries till September 2023. Analysis was conducted via RevMan where data was computed using risk ratios (RR). The Cochrane Risk of Bias tool and GRADE criteria were used to appraise and evaluate the evidence...
March 25, 2024: Clinical Reviews in Allergy & Immunology
https://read.qxmd.com/read/38525925/boosting-immune-responses-in-lung-tumor-immune-microenvironment-a-comprehensive-review-of-strategies-and-adjuvants
#11
REVIEW
Fei Gao, Xiaoqing You, Liu Yang, Xiangni Zou, Bowen Sui
The immune system has a substantial impact on the growth and expansion of lung malignancies. Immune cells are encompassed by a stroma comprising an extracellular matrix (ECM) and different cells like stromal cells, which are known as the tumor immune microenvironment (TIME). TME is marked by the presence of immunosuppressive factors, which inhibit the function of immune cells and expand tumor growth. In recent years, numerous strategies and adjuvants have been developed to extend immune responses in the TIME, to improve the efficacy of immunotherapy...
March 25, 2024: International Reviews of Immunology
https://read.qxmd.com/read/38522934/-two-cases-of-laryngeal-edema-caused-by-sublingual-allergen-immunotherapy
#12
JOURNAL ARTICLE
Yuki Maruyama, Kojiro Hirano, Eriko Sekino, Sawa Kamimura, Youichirou Narikawa, Isao Suzaki, Toshikazu Shimane
Sublingual immunotherapy is a widely used treatment, and serious adverse reactions such as anaphylaxis are rare. We report two cases of laryngeal edema as adverse reactions to sublingual immunotherapy, which could be continued due to a change in the administration method. Case 1 presents a 15-year-old male suspected to have had anaphylaxis due to the dust at the age of 6 years. He started treatment with Miticure® and developed laryngeal edema 30 minutes after taking the 10000JAU dose on the 10th day. laryngeal edema was treated with intravenous infusion...
2024: Arerugī, [Allergy]
https://read.qxmd.com/read/38522928/-classification-of-rhinitis-and-treatment-for-severe-allergic-rhinitis
#13
JOURNAL ARTICLE
Takechiyo Yamada
No abstract text is available yet for this article.
2024: Arerugī, [Allergy]
https://read.qxmd.com/read/38522142/a-cluster-of-type-i-interferon-regulated-genes-associates-with-disease-activity-and-prognosis-in-patients-with-iga-nephropathy
#14
JOURNAL ARTICLE
Shu Qu, Ting Gan, Yan-Na Wang, Yuan-Yuan Qi, Yue-Miao Zhang, Celine C Berthier, Li-Jun Liu, Su-Fang Shi, Ji-Cheng Lv, Hong Zhang, Xu-Jie Zhou
The exact pathogenesis of IgA nephropathy (IgAN) is complex and so far, not well defined. Since it has been shown that microbial infections could induce high levels of type I interferon (IFN-I) and there is an evident link between mucosal infection and gross hematuria in IgAN, we hypothesized that IFN-I may play a role in the pathogenic process. In this study, we investigated the type I interferon status in IgAN based on the expression of 17 IFN-regulated genes (IRGs) in whole blood from 59 IgAN patients in a cross-sectional study, of which 34 patients followed longitudinally...
March 23, 2024: International Immunopharmacology
https://read.qxmd.com/read/38522141/ascorbyl-palmitate-ameliorates-inflammatory-diseases-by-inhibition-of-nlrp3-inflammasome
#15
JOURNAL ARTICLE
Luchen Zhang, Guoyang Li, Bolong Lin, Hongbin He, Rongbin Zhou, Wei Jiang
The aberrant activation of NLRP3 inflammasome contributes to pathogenesis of multiple inflammation-driven human diseases. However, the medications targeting NLRP3 inflammasome are not approved for clinic use to date. Here, we show that ascorbyl palmitate (AP), a lipophilic derivative of ascorbic acid (AA) and a safe food additive, is a potent inhibitor of NLRP3 inflammasome. Compared with AA, AP inhibited the activation of NLRP3 inflammasome with increased potency and specificity. Mechanistically, AP directly scavenged mitochondrial reactive oxygen species (mitoROS) by its antioxidant activity and blocked NLRP3-NEK7 interaction and NLRP3 inflammasome assembly...
March 23, 2024: International Immunopharmacology
https://read.qxmd.com/read/38522140/citrus-pectin-protects-mice-from-burn-injury-by-modulating-intestinal-microbiota-glp-1-secretion-and-immune-response
#16
JOURNAL ARTICLE
Ji-Wei Hao, Hong-Sheng Liu, Ling-Ying Liu, Qing-Hong Zhang
Water-soluble rhamnogalacturonan-I enriched citrus pectin (WRP) has promising effect on antimicrobial defense. We aim to determine whether the modified acidic (A) or neutral (B) WRP solutions can improve intestinal microbial dysbiosis in burn-injured mice. Male Balb/c mice were gavaged with WRPs at 80, 160, 320 mg/kg. Body weight daily for 21 days before exposed to thermal injury of 15 % total body surface area and mortality was monitored. Mice with 80 mg/kg WRPs were also subjected to fecal DNAs and T cell metabonomics analysis, intestinal and plasma glucagon-like peptide 1 (GLP-1) detection, plasma defensin, immunoglobin and intestinal barrier examinations at 1 and 3d postburn (p...
March 23, 2024: International Immunopharmacology
https://read.qxmd.com/read/38522139/single-cell-transcriptome-profiling-of-infrapatellar-fat-pad-highlights-the-role-of-interstitial-inflammatory-fibroblasts-in-osteoarthritis
#17
JOURNAL ARTICLE
Hongxu Pu, Chenghao Gao, Yi Zou, Liming Zhao, Guanghao Li, Changyu Liu, Libo Zhao, Meng Zheng, Gaohong Sheng, Xuying Sun, Xingjie Hao, Chaolong Wang, Ximiao He, Jun Xiao
OBJECTIVES: Osteoarthritis (OA) is a whole-joint disease in which the role of the infrapatellar fat pad (IFP) in its pathogenesis is unclear. Our study explored the cellular heterogeneity of IFP to understand OA and identify therapeutic targets. METHODS: Single-cell and single-nuclei RNA sequencing were used to analyze 10 IFP samples, comprising 5 from OA patients and 5 from healthy controls. Analyses included differential gene expression, enrichment, pseudotime trajectory, and cellular communication, along with comparative studies with visceral and subcutaneous fats...
March 23, 2024: International Immunopharmacology
https://read.qxmd.com/read/38522138/role-of-trpv1-and-trpa1-in-tslp-production-in-nasal-epithelial-cells
#18
JOURNAL ARTICLE
Jiani Li, Fang Wang, Cuida Meng, Dongdong Zhu
BACKGROUND: TRP protein is sensitive to external temperature changes, but its pathogenic mechanism in the upper airway mucosa is still unclear. OBJECTIVE: To investigate the mechanism of TRPV1and TRPA1 in regulating the secretion of inflammatory factors in nasal epithelial cells. METHODS: The expression of TRPV1 and TRPA1 in nasal mucosal epithelial cells was investigated using immunofluorescence assays. Epithelial cells were stimulated with TRPV1 and TRPA1 agonists and antagonists, and changes in Ca2+ release and inflammatory factor secretion in epithelial cells were detected...
March 23, 2024: International Immunopharmacology
https://read.qxmd.com/read/38522137/magnolol-attenuates-macrophage-pyroptosis-triggered-by-streptococcus-equi-subsp-zooepidemicus
#19
JOURNAL ARTICLE
Yuxuan Liu, Meijun Lu, Qian Sun, Zheng Guo, Yongjin Lin, Shun Li, Yunfei Huang, Yajuan Li, Qiang Fu
Streptococcus equi subsp. zooepidemicus (SEZ) is a zoonotic bacterial pathogen that causes life-threatening infections and various diseases such as meningitis, endocarditis and pneumonia. With the use of antibiotics being severely restricted in the international community, an alternative to antibiotics is urgently needed against bacterial. In the present study, the herbal extract magnolol protected mice against SEZ infection, reflected by increased survival rate and reduced bacterial burden. A pro-inflammatory form of cell death occurred in SEZ-infected macrophage...
March 23, 2024: International Immunopharmacology
https://read.qxmd.com/read/38521942/the-role-of-molecular-diagnosis-in-anaphylactic-patients-with-dual-or-triple-sensitization-to-hymenoptera-venoms
#20
JOURNAL ARTICLE
Mohammad Hassan Bemanian, Raheleh Shokouhi Shoormasti, Saba Arshi, Mahsa Jafari, Sima Shokri, Morteza Fallahpour, Mohammad Nabavi, Fatemeh Zaremehrjardi
BACKGROUND: The poly-sensitization to Hymenoptera venom makes it difficult to select genuine allergens for immunotherapy and increases patients' costs. The objective of this study was to determine the culprit allergen in dual or triple-sensitized patients to three Hymenoptera venoms through molecular diagnosis and evaluating the results of incorporating the molecular diagnosis with skin tests. METHODS: Thirty-two patients with anaphylactic reactions and dual or triple-sensitization to Hymenoptera venoms in skin tests entered this study...
March 23, 2024: Allergy, Asthma, and Clinical Immunology
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