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marijuana pancreatitis

Wesley K Utomo, Marjan de Vries, Henri Braat, Marco J Bruno, Kaushal Parikh, Mònica Comalada, Maikel P Peppelenbosch, Harry van Goor, Gwenny M Fuhler
Medical marijuana is increasingly prescribed as an analgesic for a growing number of indications, amongst which terminal cancer and multiple sclerosis. However, the mechanistic aspects and properties of cannabis remain remarkably poorly characterized. In this study we aimed to investigate the immune-cell modulatory properties of medical cannabis. Healthy volunteers were asked to ingest medical cannabis, and kinome profiling was used to generate comprehensive descriptions of the cannabis challenge on inflammatory signal transduction in the peripheral blood of these volunteers...
2017: Frontiers in Molecular Neuroscience
Neerja Gulati, Rakesh Vadde, Setu Patolia, Frances Schmidt, Muhammad Perwaiz, Dharani Narendra, Joseph Quist, Danilo Enriquez, Saurav Pokharel
SESSION TYPE: Pleural Case Report PostersPRESENTED ON: Tuesday, October 23, 2012 at 01:30 PM - 02:30 PMINTRODUCTION: Primary spontaneous pneumothoraces are usually due to rupture of apical pleural blebs,small cystic spaces that lie within or immediately under the visceral pleura. Recurrent spontaneous pneumothorax (SP) may present either as a primary pneumothorax in young and otherwise healthy patients or as a secondary pneumothorax because of a complication of an underlying lung disease.CASE PRESENTATION: 48 year old male presented to emergency department with complaint of multiple episodes of vomiting and upper abdominal pain of 2 days duration...
October 1, 2012: Chest
Mehran Howaizi, Mouhamad Chahine, Fadi Haydar, Yassine Jemaa, Emmanuel Lapoile
Acute pancreatitis has a large number of causes. Major causes are alcohol and gallstones. Toxic causes, mainly represented by medication-induced pancreatitis account for less than 2% of the cases. Cannabis is an anecdotally reported cause of acute pancreatitis. Six cases have previously been reported. Herein we report a new case of cannabis-induced recurrent acute pancreatitis.
December 2012: Acta Gastro-enterologica Belgica
Houissa Fatma, Bouraoui Mouna, Mouelhi Leila, Debbeche Radhouane, Najjar Taoufik
CONTEXT: Drugs of all types are related to the etiology of pancreatitis in approximately 2% of cases. However, there have been very few reports of acute pancreatitis associated with cannabis use in the general population. CASE REPORT: This report is the first such case in our country, and involves a 22-year-old North African man who presented to our emergency department with transfixiant epigastric abdominal pain, nausea and vomiting. The patient denied any past or familial medical history, was taking no medications chronically and had no history of trauma...
February 2013: Clinics and Research in Hepatology and Gastroenterology
Olivier Belze, Annick Legras, Stephan Ehrmann, Denis Garot, Dominique Perrotin
No abstract text is available yet for this article.
January 2011: American Journal of Emergency Medicine
Beth Han, Joseph C Gfroerer, James D Colliver
PURPOSE: To estimate and compare prevalence rates of lifetime health conditions by inferred duration of illicit drug use among the general U.S. adult population and to investigate associations between duration of use of each specific illicit drug (marijuana, cocaine, heroin, hallucinogens, or inhalant) and each lifetime health condition after controlling for potential confounding factors. METHODS: Data from respondents aged 35 to 49 (N = 29,195) from the 2005-2007 National Surveys on Drug Use and Health (NSDUH) were analyzed...
April 2010: Annals of Epidemiology
Kurt A Wargo, Bridget N Geveden, Victoria J McConnell
CONTEXT: There is only one previously published case report of acute pancreatitis secondary to the use of tetrahydrocannabinoid. While drugs, in general, account for 2% of all the causes of acute pancreatitis, we add to the literature three additional cases of cannabis-induced pancreatitis. CASES: The first case occurred in a 22-year-old man who admitted to smoking tetrahydrocannabinoid heavily over the days prior to admission. The second case involved a 23-year-old man with multiple admissions for tetrahydrocannabinoid-induced pancreatitis...
2007: JOP: Journal of the Pancreas
L Weiss, M Zeira, S Reich, M Har-Noy, R Mechoulam, S Slavin, R Gallily
Cannabidinoids are components of the Cannabis sativa (marijuana) plant that have been shown capable of suppressing inflammation and various aspects of cell-mediated immunity. Cannabidiol (CBD), a non-psychoactive cannabidinoid has been previously shown by us to suppress cell-mediated autoimmune joint destruction in an animal model of rheumatoid arthritis. We now report that CBD treatment significantly reduces the incidence of diabetes in NOD mice from an incidence of 86% in non-treated control mice to an incidence of 30% in CBD-treated mice...
March 2006: Autoimmunity
Kazuhisa Matsuda, Yukio Mikami, Kazunori Takeda, Shoji Fukuyama, Shinichi Egawa, Makoto Sunamura, Ikurou Maruyama, Seiki Matsuno
It has recently been recognized that anandamide (arachidonylethanolamide), which is an endogeneous-cannabinoid (endocannabinoid), mediates septic shock. Cannabinoid means a mind-active material in cannabis (marijuana). Anandamide is mainly produced by macrophages. Cannabinoid 1 (CB1) receptor, which is one of the cannabiniod receptors, is also known to mediate hypotensive shock. The role of endocannabinoids in the progression of acute pancreatitis is unclear. The aims of this study are to clarify their relationship and to find a new therapeutic strategy by regulating the endocannabinoid signaling in acute pancreatitis...
October 2005: Tohoku Journal of Experimental Medicine
(no author information available yet)
1-Trans-delta(9)-tetrahydrocannabinol (THC) was nominated by the National Cancer Institute to the NTP for study because it is the major psychoactive component of marijuana and a widely used Schedule I substance. Male and female F344/N rats and B6C3F1 mice received THC (97% pure) in corn oil by gavage for 13 weeks, 13 weeks with a 9-week recovery period, or 2 years. Genetic toxicology studies were conducted in Salmonella typhimurium, cultured Chinese hamster ovary cells, and mouse peripheral blood cells. 13-WEEK STUDY IN RATS: Groups of 10 male and 10 female rats received 0, 5, 15, 50, 150, or 500 mg THC/kg body weight in corn oil by gavage, 5 days per week for 13 weeks...
November 1996: National Toxicology Program Technical Report Series
J G Duarte, A F do Nascimento, J G Pantoja, C P Chaves
BACKGROUND: The acute and chronic effects of cocaine over various organ systems have been well documented. A more recent approach to the effects of this drug has focused on the immunological consequences of its exposure, with results that indicate a possible carcinogenic effect. METHODS: A chart review was made in order to search for young pancreatic adenocarcinoma patients (arbitrarily defined as younger than 40) who made use of inhaled cocaine. This age was chosen because of a higher probability of cocaine addiction than at older ages...
November 1999: American Journal of Surgery
R M Whitfield, L M Bechtel, G H Starich
Therapeutic observations suggest that azidothymidine (AZT)-resistant HIV+/AIDS patients are frequently offered AZT/dideoxycytidine (DDC) or dideoxyinosine (DDI) therapy. The latter therapies have been associated with the development of acute pancreatitis. During the initial portion of this study, when patients reported limiting ethanol consumption, an increase in CD4+, a decrease in amylase, and a decrease in lipase was observed in patients on DDI monotherapy. Marinol/marijuana usage was associated with depressed CD4+ counts and elevated amylase levels within the DDI subgroup...
February 1997: Alcoholism, Clinical and Experimental Research
A Dionyssiou-Asteriou, A Kalofoutis, C Maravelias, A Koutselinis
No abstract text is available yet for this article.
1990: Journal of Toxicology. Clinical Toxicology
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