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Smoking AND multiple sclerosis

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https://www.readbyqxmd.com/read/28432518/correlation-between-heavy-metal-exposure-and-gstm1-polymorphism-in-iranian-multiple-sclerosis-patients
#1
Mehdi Aliomrani, Mohammad A Sahraian, Hamid Shirkhanloo, Mohammad Sharifzadeh, Mohammad R Khoshayand, Mohammad H Ghahremani
Multiple sclerosis (MS) is an immune-mediated chronic inflammatory disease of the central nervous system. Various exposures to heavy metals can lead to toxicity and oxidative stress. While glutathione-S-transferases are known as oxidative stress-related genes and involved in metal biotransformation. The aim of the present study is to investigate the correlation of GSTM1 polymorphism in MS patients and the possible association with blood concentration of arsenic (As) and cadmium (Cd) as major heavy metal pollutants...
April 21, 2017: Neurological Sciences
https://www.readbyqxmd.com/read/28427711/maternal-and-perinatal-characteristics-of-infants-who-later-in-life-developed-multiple-sclerosis-record-linkage-study
#2
Alexander Goldacre, Julia Pakpoor, Michael Goldacre
BACKGROUND: Pre-natal and early life factors may have a role in multiple sclerosis (MS) pathogenesis in some people. However, the reporting of any influence of maternal and perinatal factors on MS risk has been limited. We aimed to study maternal and perinatal characteristics of babies who went on to develop MS. METHODS: Data were analysed from the historical Oxford Record Linkage Study dataset 1970-1989, which incorporated a specialised maternity dataset with record linkage between mother and baby, covering a population of 850,000...
April 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/28402456/smoking-cessation-and-the-reduction-of-disability-progression-in-multiple-sclerosis-a-cohort-study
#3
Radu Tanasescu, Cris S Constantinescu, Christopher R Tench, Ali Manouchehrinia
Background: Smoking is associated with a more severe disease course in people with multiple sclerosis (MS). The magnitude of effect of smoking cessation on MS progression is unknown. The aim of this study was to quantify the impact of smoking cessation on reaching MS disability milestones. Methods: This is a cross-sectional study with retrospective reports. A comprehensive smoking questionnaire was sent to 1270 patients with MS registered between 1994 and 2013 in the Nottingham University Hospital MS Clinics database...
April 10, 2017: Nicotine & Tobacco Research: Official Journal of the Society for Research on Nicotine and Tobacco
https://www.readbyqxmd.com/read/28386263/adaptive-immunity-is-the-key-to-the-understanding-of-autoimmune-and-paraneoplastic-inflammatory-central-nervous-system-disorders
#4
REVIEW
Robert Weissert
There are common aspects and mechanisms between different types of autoimmune diseases such as multiple sclerosis (MS), neuromyelitis optica spectrum disorders (NMOSDs), and autoimmune encephalitis (AE) as well as paraneoplastic inflammatory disorders of the central nervous system. To our present knowledge, depending on the disease, T and B cells as well as antibodies contribute to various aspects of the pathogenesis. Possibly the events leading to the breaking of tolerance between the different diseases are of great similarity and so far, only partially understood...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28367411/multiple-sclerosis-pathogenesis-symptoms-diagnoses-and-cell-based-therapy
#5
REVIEW
Nazem Ghasemi, Shahnaz Razavi, Elham Nikzad
Multiple sclerosis (MS) is a chronic inflammatory disease characterized by central nervous system (CNS) lesions that can lead to severe physical or cognitive disability as well as neurological defects. Although the etiology and pathogenesis of MS remains unclear, the present documents illustrate that the cause of MS is multifactorial and include genetic predisposition together with environmental factors such as exposure to infectious agents, vitamin deficiencies, and smoking. These agents are able to trigger a cascade of events in the immune system which lead to neuronal cell death accompanied by nerve demyelination and neuronal dysfunction...
April 2017: Cell Journal
https://www.readbyqxmd.com/read/28351749/the-link-between-smoking-status-and-co-morbid-conditions-in-individuals-with-multiple-sclerosis-ms
#6
Pamela Newland, Louise Flick, Amber Salter, David Dixon, Mark P Jensen
BACKGROUND: In individuals with multiple sclerosis (MS) comorbidities and quality of life (QOL) may be affected by tobacco use. OBJECTIVE: To evaluate the associations between smoking status, in particular quit attempts, and comorbidities among individuals with MS. METHODS: We used a web-based survey to obtain cross-sectional data from 335 individuals with MS who were members of the Gateway Chapter of the National MS Society email registry...
March 23, 2017: Disability and Health Journal
https://www.readbyqxmd.com/read/28283105/perinatal-characteristics-and-obstetric-complications-in-mothers-with-multiple-sclerosis-record-linkage-study
#7
Alexander Goldacre, Julia Pakpoor, Michael Goldacre
BACKGROUND: Multiple sclerosis (MS) predominantly onsets in women of reproductive age. The possibility of adverse obstetric and perinatal outcomes is a likely source of concern to pregnant women with MS and their clinicians. We aimed to compare the characteristics of the pregnancies of mothers with or without MS. METHODS: The historical Oxford Record Linkage Study specialised maternity dataset (850,000 people, 1970-1989), with record-linkage between mother and baby, was analysed...
February 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/28273774/physical-activity-is-associated-with-a-decreased-multiple-sclerosis-risk-the-envims-study
#8
Kristin Wesnes, Kjell-Morten Myhr, Trond Riise, Marianna Cortese, Maura Pugliatti, Inger Boström, Anne-Marie Landtblom, Christina Wolfson, Kjetil Bjørnevik
BACKGROUND: The lifestyle factors smoking and obesity have been associated with the risk of multiple sclerosis (MS). Physical activity (PA) may also be of importance. OBJECTIVE: To examine the association between PA and MS risk in Italy, Norway, and Sweden and to evaluate the possible influence by established risk factors. METHODS: In this case-control study, 1904 cases and 3694 controls were asked to report their average weekly amounts of light and vigorous PA during adolescence on a scale ranging from none to more than 3 hours activity...
February 1, 2017: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/28239937/smoking-does-not-influence-disability-accumulation-in-primary-progressive-multiple-sclerosis
#9
O Javizian, L M Metz, S Deighton, M W Koch
BACKGROUND AND PURPOSE: The modifiable risk factor cigarette smoking has been associated with an increased risk of developing multiple sclerosis (MS) and with disease activity in relapsing-remitting MS. However, less is known about the effect of smoking on disease progression in progressive MS. Here the association between cigarette smoking and disability accumulation in primary progressive MS (PPMS) is investigated. METHODS: Kaplan-Meier survival analyses and Cox proportional hazard modelling were used to investigate the influence of cigarette smoking on the risk of reaching Expanded Disability Status Scale (EDSS) 4 and 6 as well as the time from EDSS 4 to 6 in patients with PPMS...
April 2017: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/28179539/smoking-reduces-circulating-cd26-hi-cd161-hi-mait-cells-in-healthy-individuals-and-patients-with-multiple-sclerosis
#10
Cecilie Ammitzbøll, Lars Börnsen, Jeppe Romme Christensen, Rikke Ratzer, Birgitte Romme Nielsen, Helle B Søndergaard, Marina R von Essen, Finn Sellebjerg
Upon chronic cigarette smoke exposure, inhaled antigens and irritants cause altered lung immune homeostasis. Circulating immune cells are affected, and smoking is associated with an increased risk of developing various disorders, including multiple sclerosis (MS). This study was conducted to determine the impact of smoking on circulating immune cell subsets. Furthermore, we determined whether any smoking-associated changes were related to MS. With the use of flow cytometry, CFSE assays, and ELISpot assays, we analyzed circulating immune cell phenotypes and quantified antigen-induced proliferation and cytokine secretion in smokers and nonsmokers in a cohort of 100 healthy individuals (HI)...
February 8, 2017: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/28165143/potentially-modifiable-factors-associated-with-physical-activity-in-individuals-with-multiple-sclerosis
#11
Nadia Reider, Amber R Salter, Gary R Cutter, Tuula Tyry, Ruth Ann Marrie
Physical activity levels among persons with multiple sclerosis (MS) are worryingly low. We aimed to identify the factors associated with physical activity for people with MS, with an emphasis on factors that have not been studied previously (bladder and hand dysfunction) and are potentially modifiable. This study was a secondary analysis of data collected in the spring of 2012 during the North American Research Committee on Multiple Sclerosis (NARCOMS) Registry. NARCOMS participants were surveyed regarding smoking using questions from the Behavioral Risk Factor Surveillance Survey; disability using the Patient Determined Disease Steps; fatigue, cognition, spasticity, sensory, bladder, vision and hand function using self-reported Performance Scales; health literacy using the Medical Term Recognition Test; and physical activity using questions from the Health Information National Trends Survey...
April 2017: Research in Nursing & Health
https://www.readbyqxmd.com/read/28156186/polyunsaturated-fatty-acids-and-the-risk-of-multiple-sclerosis
#12
Kjetil Bjørnevik, Tanuja Chitnis, Alberto Ascherio, Kassandra L Munger
BACKGROUND: Results from previous studies on polyunsaturated fatty acid (PUFA) intake and multiple sclerosis (MS) risk are conflicting. OBJECTIVE: To prospectively investigate the association between dietary intake of PUFA and MS risk. METHODS: We followed 80,920 women from Nurses' Health Study (1984-2004) and 94,511 women from Nurses' Health Study II (1991-2009) who reported on diet using a validated food frequency questionnaire every 4 years and identified 479 incident MS cases during follow-up...
January 1, 2017: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/28151074/a-systematic-review-of-the-effects-of-modifiable-risk-factor-interventions-on-the-progression-of-multiple-sclerosis
#13
Susanne Hempel, Glenn D Graham, Ning Fu, Elena Estrada, Annie Y Chen, Isomi Miake-Lye, Jeremy N V Miles, Roberta Shanman, Paul G Shekelle, Jessica M Beroes, Mitchell T Wallin
BACKGROUND: Several risk factors are associated with multiple sclerosis (MS) progression and may be amenable to intervention. OBJECTIVE: To systematically review the evidence for interventions targeting risk factors for MS progression. METHODS: We searched six databases and existing reviews till March 2015 and consulted with experts to identify randomized controlled trials (RCTs) of interventions targeting MS risk factors (PROSPERO 2015:CRD42015016461)...
April 2017: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/28151053/a-systematic-review-of-modifiable-risk-factors-in-the-progression-of-multiple-sclerosis
#14
Susanne Hempel, Glenn D Graham, Ning Fu, Elena Estrada, Annie Y Chen, Isomi Miake-Lye, Jeremy N V Miles, Roberta Shanman, Paul G Shekelle, Jessica M Beroes, Mitchell T Wallin
BACKGROUND: The presenting symptoms and rate of progression of multiple sclerosis (MS) are very heterogeneous. The diverse clinical manifestations and the clinical course of the disease may vary with modifiable risk factors. OBJECTIVE: To systematically review modifiable risk factors and exposures associated with MS progression. METHODS: We searched six databases till March 2015, reference-mined reviews, and consulted with experts (PROSPERO 2015:CRD42015016461)...
April 2017: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/28127518/the-lack-of-association-between-angiotensin-converting-enzyme-gene-insertion-deletion-polymorphism-and-nicotine-dependence-in-multiple-sclerosis
#15
Sergej Nadalin, Alena Buretić-Tomljanović, Polona Lavtar, Nada Starčević Čizmarević, Alenka Hodžić, Juraj Sepčić, Miljenko Kapović, Borut Peterlin, Smiljana Ristić
OBJECTIVE: Blood-borne angiotensin II is generated from angiotensinogen via cleavage by renin and angiotensin-converting enzyme (ACE), an enzymatic cascade known as the renin-angiotensin system (RAS). Several lines of evidence indicate that ACE, beyond its classical role of mediating blood pressure regulation, might contribute to the etiology of substance addictions by influencing dopaminergic signaling. A functional insertion/deletion (I/D) polymorphism of the ACE gene was associated with risk for being a smoker among individuals with depression and with smoking severity in studies comprising patients with depression and healthy controls...
January 2017: Brain and Behavior
https://www.readbyqxmd.com/read/28073764/causal-effect-of-genetic-variants-associated-with-body-mass-index-on-multiple-sclerosis-susceptibility
#16
Milena A Gianfrancesco, M Maria Glymour, Stefan Walter, Brooke Rhead, Xiaorong Shao, Ling Shen, Hong Quach, Alan Hubbard, Ingileif Jónsdóttir, Kári Stefánsson, Pernilla Strid, Jan Hillert, Anna Hedström, Tomas Olsson, Ingrid Kockum, Catherine Schaefer, Lars Alfredsson, Lisa F Barcellos
Multiple sclerosis (MS) is an autoimmune disease with both genetic and environmental risk factors. Recent studies indicate that childhood and adolescent obesity double the risk of MS, but this association may reflect unmeasured confounders rather than causal effects of obesity. We used separate-sample Mendelian randomization to estimate the causal effect of body mass index (BMI) on susceptibility to MS. Using data from non-Hispanic white members of the Kaiser Permanente Medical Care Plan of Northern California (KPNC) (2006-2014; 1,104 cases of MS and 10,536 controls) and a replication data set from Sweden (the Epidemiological Investigation of MS (EIMS) and the Genes and Environment in MS (GEMS) studies, 2005-2013; 5,133 MS cases and 4,718 controls), we constructed a weighted genetic risk score using 97 variants previously established to predict BMI...
February 1, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28059618/smokers-with-ms-have-greater-decrements-in-quality-of-life-and-disability-than-non-smokers
#17
Farren Bs Briggs, Douglas D Gunzler, Daniel Ontaneda, Ruth Ann Marrie
BACKGROUND: Tobacco smoke plays a pathogenic role in multiple sclerosis (MS) and may accelerate disease progression, yet, some people with MS continue to smoke after disease onset. The average smoker reports diminished health-related quality of life (HRQOL) across many populations. OBJECTIVES: To describe the relationships between smoking status and HRQOL, disease activity, and global disability in a US population with MS. METHODS: We compared smokers to non-smokers in 950 responders to the Spring 2014 update survey completed by North American Research Committee on Multiple Sclerosis (NARCOMS) registry participants...
January 1, 2017: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/27999524/individual-and-co-occurring-snap-risk-factors-smoking-nutrition-alcohol-consumption-and-physical-activity-in-people-with-multiple-sclerosis
#18
Julia M Balto, Ipek Ensari, Elizabeth A Hubbard, Naiman Khan, Jennifer L Barnes, Robert W Motl
Background: Smoking, poor nutrition, excess alcohol consumption, and insufficient physical activity underlie most preventable causes of morbidity in the general population and may be associated with comorbidities and health outcomes in multiple sclerosis (MS). However, the frequency of co-occurrence of these risk factors in people with MS remains unclear. Methods: Sixty-nine individuals with MS completed self-report measures of smoking status, nutrition, alcohol use, physical activity levels, and sociodemographic and clinical characteristics...
November 2016: International Journal of MS Care
https://www.readbyqxmd.com/read/27998160/risk-factors-of-multiple-sclerosis-and-their-relation-with-disease-severity-a-cross-sectional-study-from-iran
#19
Maryam Abbasi, Seyed Massood Nabavi, Seyed-Mohammad Fereshtehnejad, Iman Ansari, Nikan Zerafatjou, Vahid Shayegannejad, Seyed Ehsan Mohammadianinejad, Mahdi Farhoudi, Abbas Noorian, Nazanin Razazian, Mahmoud Abedini, Fardin Faraji
BACKGROUND: Many risk factors have been investigated in multiple sclerosis (MS); however, few studies have focused on the association between risk factors and the disease severity. The aim of our study was to evaluate the association between some of these risk factors and MS severity in a population sample of Iranian patients. METHODS: This cross-sectional study was conducted on 660 patients with MS. In addition to demographic variables, many potential risk factors were recorded...
December 2016: Archives of Iranian Medicine
https://www.readbyqxmd.com/read/27996340/geographic-variation-as-a-risk-factor-for-digital-ulcers-in-systemic-sclerosis-patients-a-multicentre-registry
#20
Ejr Souza, C S Muller, Amc Horimoto, R A Rezende, I Guimarães, H A Mariz, A T Dantas, I P Da Costa, Apt Del-Rio, J Sekiyama, C B Kahwage, C Kayser
OBJECTIVE: To evaluate the influence of geographic variation on the risk of digital ulcer (DU) development in systemic sclerosis (SSc) patients. METHODS: This cross-sectional, multicentre study evaluated patients with SSc from centres located in different geographic regions of Brazil (subtropical and tropical climate zones). Demographic and clinical data were collected. RESULTS: The study included 141 patients with SSc (26 from the subtropical and 115 from the tropical zone)...
December 20, 2016: Scandinavian Journal of Rheumatology
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