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antirretroviral therapy

Ivana Cristina Vieira de Lima, Maria da Conceição Dos Santos Oliveira Cunha, Gilmara Holanda da Cunha, Marli Teresinha Gimeniz Galvão
OBJECTIVE: To analyze the reproductive aspects and knowledge of family planning among women with Acquired Immunodeficiency Syndrome (AIDS). METHOD: Cross-sectional and descriptive study carried out from January to December, 2015, in the outpatient care of infectious disease unit in a hospital located in Fortaleza, Ceará. Data were collected through a form applied by interview in a private setting. RESULTS: 102 women participated in the study...
May 25, 2017: Revista da Escola de Enfermagem da U S P
Eva Poveda, Enrique Martin-Gayo
In the absence of antirretroviral therapy (ART), HIV infection leads to progression to AIDS in most infected individuals. However, there is a small group of HIV-infected patients capable of spontaneously controlling HIV infection, known as the elite controllers (less than 1% of total infected population). These patients maintain undetectable levels of HIV replication, in part, due to a continuously effective HIV specific T cell response. Moreover, in HIV-infected patients with suppressed viremia under ART, a chronic activation of the immune system persist, which can be related to a poor clinical outcome including death, development of co-morbidities, AIDS and non-AIDS defining events...
January 2017: AIDS Reviews
Wendel Mombaque Dos Santos, Silvia Regina Secoli, Stela Maris de Mello Padoin
Objective: to investigate potential drug-drug interactions (PDDI) in patients with HIV infection on antiretroviral therapy. Methods: a cross-sectional study was conducted on 161 adults with HIV infection. Clinical, socio demographic, and antiretroviral treatment data were collected. To analyze the potential drug interactions, we used the software Micromedex(r). Statistical analysis was performed by binary logistic regression, with a p-value of ≤0.05 considered statistically significant...
November 21, 2016: Revista Latino-americana de Enfermagem
Juan Macías, Antonio Rivero
Related to the use of telaprevir in patients with HIV and genotype 1 hepatitis C virus, there is available data from a phase IIb clinical trial in patients not previously treated for HCV, study 110; and preliminary data from a real practice study in patients with previous failure to a HCV treatment, study ARNSHC26 (TelapreVIH). Additionally, there are two ongoing phase III studies in coinfected patients, C3008 and 115, both in naive and previously treated patients. In the 110 study, rates of sustained viral response (SVR) in patients receiving the triple combination of pegylated interferon + ribavirin + telaprevir was 74%...
July 2013: Enfermedades Infecciosas y Microbiología Clínica
Sara Corchado, Mercedes Márquez, Montserrat Montes de Oca, Paula Romero-Cores, Clotilde Fernández-Gutiérrez, José-Antonio Girón-González
OBJECTIVE: Analysis of the contribution of genetic (single nucleotide polymorphisms (SNP) at position -238 and -308 of the tumor necrosis factor alpha (TNF-α) and -592 of the interleukin-10 (IL-10) promotor genes) and of classical factors (age, alcohol, immunodepression, antirretroviral therapy) on the risk of liver cirrhosis in human immunodeficiency (HIV)-hepatitis C (HCV) virus coinfected patients. PATIENTS AND METHODS: Ninety one HIV-HCV coinfected patients (50 of them with chronic hepatitis and 41 with liver cirrhosis) and 55 healthy controls were studied...
2013: PloS One
Enric Pedrol, Juan Carlos López-Bernaldo, Sheila Ruiz, Henar Hevia, Francisco Ledesma
INTRODUCTION: In 2009 a deep change in ARV treatment took place in Spain with the introduction of new ARV drugs. The principal objective of the study was to determine the clinical situation of the patients in which DRV/r was introduced in the ARV therapy. METHODS: Observational, cross sectional and multicentre study in which 91 reference hospitals participated. Patient's enrollment was carried out between 2008 and 2009. Data were collected retrospectively considering standard clinical practice...
June 2013: Revista Española de Quimioterapia: Publicación Oficial de la Sociedad Española de Quimioterapia
Yanneth Moya, Fernando Bernal, Eliana Rojas, Elizabeth Barthel
Adherence to antiretroviral therapy is key contributor to decreasing morbidity and mortality from HIV/ AIDS infection. However, it is affected by treatment-related factors including the multiple adverse reactions and interactions arising from chronic polypharmacy. In order to determine drug-related problems, 66 outpatients from Hospital Carlos Van Buren on antiretroviral therapy were monitored. 100 % had medication-related problems and 46.1% of those problems were related to the safety of the therapy. Hypertriglyceridemia associated to the combined use of both nucleoside reverse transcriptase inhibitor and a non-nucleoside reverse transcriptase inhibitor was the most frequent adverse reaction...
August 2012: Revista Chilena de Infectología: órgano Oficial de la Sociedad Chilena de Infectología
Pedro Raimundo, A Miranda, J Ribeiro, Kamal Mansinho
The increased cardiovascular risk has been implicated in both HIV infection and antirretroviral therapy. The endothelial dysfunction triggered by the infection and the metabolic abnormalities associated with therapy predispose to premature atherosclerosis. The recognition of the increased cardiovascular risk in these patients will allow more appropriate prevention strategies, as well as therapy optimization with lipid-lowering agents and antirretroviral therapy modification.
July 2010: Acta Médica Portuguesa
Armando Herrera-Arellano, Minerva Jaime-Delgado, Sara Herrera-Alvarez, Jesús Oaxaca-Navarro, Eduardo Salazar-Martínez
OBJECTIVE: To evaluate the use of complementary alternative medicine (CAM) in patients infected with the human immunodeficiency virus (HIV), and to identify the type and factors associated to its use. METHODS: Cross-sectional study made in HIV clinics of three majors institutions from Morelos State, Mexico; the sample was 293 subjects; a specific questionnaire looking for demographic information and CAM use was applied. RESULTS: The use of CAM was 73...
November 2009: Revista Médica del Instituto Mexicano del Seguro Social
J I Bernardino de la Serna, M Mora Rillo, J R Arribas López
Highly active antirretroviral therapy has transformed the prognosis of patient infected with human immunodeficiency virus. The efficacy of these drugs has shifted the clinicians; attention to other therapeutic aspects like QD regimens, fixed dose combinations and clinical safety. Tenofovir disoproxil fumarate(TDF) is a nucleoside monophosphate (nucleotide) analogue that inhibits reverse trascriptase enzyme. It's administered in a q.d. regimen and it's recommended by most of the clinical guidelines as a start regimen in combination with two other drugs...
June 2008: Enfermedades Infecciosas y Microbiología Clínica
Ireneia Lino, António Sousa, José Correia
The spectrum of human immunodeficiency virus infection (HIV) is changing. New drug treatments have reduced morbidity and mortality of this disease, therefore it is necessary to start treating the HIV infection as a chronical disease. The association of the stroke with the HIV infection was inicially thought to be a result of other opportunistic infeccions and tumors. However, the vascular disease associated with HIV infection has been a subject of research and debate. New evidence shows that the vascular diseases could be a threat for the pacients doing highly active antirretroviral therapy (HAART)...
November 2007: Acta Médica Portuguesa
E Santos Corraliza, A Fuertes Martín
The suppression of plasma viral loads in HIV infected patients to less than the limit of quantification of the most sensitive commercially available assays and the coincident improvement in CD4 T cell counts is associated with a decrease in the risk of new opportunistic infections in this patients. The descent at the morbibility and mortality is specialy important since the introduction in 1996 the hard activity antirretroviral therapy (HAART). However, prolonged treatment with combination regimens can be difficult to sustain because of problems with adherence and toxic effects...
July 2006: Anales de Medicina Interna: Organo Oficial de la Sociedad Española de Medicina Interna
Cristina Rius, Gemma Binefa, Alexandra Montoliu, Anna Esteve, Glòria Ribas, Rosa Gispert, Jordi Casabona
BACKGROUND AND OBJECTIVE: Our goal was to assess survival changes among AIDS patients in Catalonia. PATIENTS AND METHOD: We analyzed AIDS cases older than 13 years notified in the Catalonian AIDS Registry from January 1981 to December 2001. Sex, age, transmission category, AIDS-defining disease and diagnostic period were included. The survival cumulative risk was computed for each diagnostic period with Kaplan-Meier methods. RESULTS: During the study period 13,485 AIDS cases were reported...
July 1, 2006: Medicina Clínica
B Roca
In the last few years, recently developed antirretroviral treatment has allowed a dramatic improvement in the prognosis of HIV disease. As a result, other medical problems are taking increasing relevance in the follow up of the patients infected by such virus. In this article, metabolic disorders associated with HIV, as well as those provoked by antiretroviral therapy, are comprehensively reviewed.
November 2003: Anales de Medicina Interna: Organo Oficial de la Sociedad Española de Medicina Interna
M A Mur Lalaguna, R Cobo Campos, M F T Hurtado Gómez, M J Martínez Tutor
UNLABELLED: Clinical efficacy of antiretroviral treatment requires drugs to maintain a plasma concentration over MIC90. One of the facts that can prevent drugs from reaching and maintaining required concentrations are pharmacological drug interactions. OBJECTIVE: The aim of this study is to identify the main interactions between antiretroviral medicines and concomitant treatment in a HIV positive group of patients in a general hospital. Clinical significance and the way to avoid or minimize these interactions is indicated...
March 2003: Farmacia Hospitalaria
E Sáiz Hervas, V Castilla Castellano, J Miquel Plaza, A M Benito Blanco, M M Martín Llorens, M Pastor de Blas, P Izquierdo, M A Muñoz Jareño, A Sierra, M A Nieto, A M Moreno Collado, C Fraguas
INTRODUCTION: Early use of prophylactic regimens against Pneumocystis carinii and zidovudine therapy, may have modified the natural history of patients with HIV-1 infection. We describe the incidence of opportunistic infections and analize the mortality rate in those patients to check the occurrence of any change in the above mentioned natural history. PATIENTS: Clinical charts of patients with HIV-1 infection attending our hospital are reviewed, from november 1987 to june 1994...
March 1998: Anales de Medicina Interna: Organo Oficial de la Sociedad Española de Medicina Interna
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