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hemolytic anaemia

G S Kew, J Cho, A Lateef
We describe a gravid 37-year-old Chinese lady with known triple positive primary antiphospholipid syndrome with previous recurrent deep vein thrombosis and early spontaneous miscarriages. She was managed with low-molecular weight heparin, aspirin, hydroxychloroquine, prednisolone and monthly intravenous immunoglobulin.She presented with recurrent per-vaginal bleeding at 22 weeks of gestation and was found to have abruptio placentae. Anti-coagulation was held off. She subsequently delivered a stillborn at 24 weeks and anti-coagulation was restarted...
October 1, 2016: Lupus
Ghada O M Ali, Yahya S Abdal Gader, Elfatih S Abuzedi, Bakhieta A I Attalla
Sickle cell anaemia (SCA) is one of the commonest chronic hemolytic anaemias in the Sudan; it is a disease with high mortality and morbidity. This study was conducted aiming to observe the clinical pattern of cardiac abnormalities in children with sickle cell anaemia, and to assess the relationship between the cardiac abnormalities and the severity of the disease. The study was conducted in sickle cell disease clinic at Khartoum Children Emergency Hospital. The study group consisted of 289 patients with sickle cell anaemia, age range from 6 months to 18 years...
2012: Sudan J Paediatr
O Taton, M Delhaye, P Stordeur, T Goodship, A Le Moine, A Massart
Atypical haemolytic uraemic syndrome (aHUS) is a rare but life-threatening complement system-related disorder, characterized by renal failure, non-immune haemolytic anaemia and thrombo-cytopenia. We report on a young woman who developed a pancreatitis-induced aHUS following a routine procedure of endoscopic retrograde cholangiopancreatography. The patient was successively treated by 2 plasma exchanges with fresh frozen plasma and eculizumab, a monoclonal antibody designed to block terminal complement activation...
April 2016: Acta Gastro-enterologica Belgica
S Meade, S Kotha, A Gera, A Loganayagam
No abstract text is available yet for this article.
June 2016: British Journal of Hospital Medicine
A Thedsawad, O Taka, W Wanachiwanawin
OBJECTIVES: This study was to investigate the use of flow cytometry for detection and quantitation of red blood cells (RBC) bound IgG in immune hemolysis of patients with autoimmune hemolytic anaemia (AIHA) and systematic lupus erythematosus (SLE). BACKGROUND: Two to ten percent of patients with warm-autoimmune hemolytic anaemia (WAIHA) exhibit a negative direct Coombs test. Flow cytometry has been applied to detect RBC bound IgG with high accuracy, reproducibility and sensitivity...
April 2016: Transfusion Medicine
Iulia Tudorascu, Simona Neamtu, Liliana Stanca, Mirela Siminel, Lorena Dijmarescu, Magdalena Manolea, Liliana Novac, Elis Pirgaru, Suzana Danoiu
Haemoglobinopathies are hereditary conditions in which the fundamental lesion affects the synthesis rate or the structure of the globin in normal hemoglobin. The synthesis of the polypeptide chains in globin is genetically coded. Clinically, haemoglobinopathies manifest most commonly in the form of hemolytic anemia and, more rarely, cyanosis and polyglobulia. They differ from "acquired haemoglobinopathies", such as methemoglobinemia, in which hemoglobin is usually compromised due to the action of toxic substances...
October 2014: Current Health Sciences Journal
D Laužikienė, D Ramašauskaitė, T Lūža, R Lenkutienė
Background: Autoimmune haemolytic anaemia (AIHA), caused primarily by pregnancy, is poorly described in the literature. There is especially little information on coping with cases that are not responsive to glucocorticoid treatment, monitoring a fetal condition, and identifying fetal haemolytic anaemia as early as possible. Case: A case of pregnancy-induced autoimmune haemolytic anaemia is reported with major problems in differential diagnosis, treatment and the risks posed to both the mother and the fetus...
November 2015: Geburtshilfe und Frauenheilkunde
Sim Kheng, Sinoun Muth, Walter R J Taylor, Narann Tops, Khem Kosal, Khon Sothea, Phum Souy, Saorin Kim, Chuor Meng Char, Chan Vanna, Po Ly, Pascal Ringwald, Virak Khieu, Alexandra Kerleguer, Pety Tor, John K Baird, Steven Bjorge, Didier Menard, Eva Christophel
BACKGROUND: Primaquine is used to prevent Plasmodium vivax relapse; however, it is not implemented in many malaria-endemic countries, including Cambodia, for fear of precipitating primaquine-induced acute haemolytic anaemia in patients with glucose-6-phosphate dehydrogenase deficiency (G6PDd). Reluctance to use primaquine is reinforced by a lack of quality safety data. This study was conducted to assess the tolerability of a primaquine regimen in Cambodian severely deficient G6PD variants to ascertain whether a weekly primaquine could be given without testing for G6PDd...
2015: BMC Medicine
D K Gold, T Loirat, A P Farrell
To quantify cardiorespiratory response to experimental anaemia in rainbow trout Oncorhynchus mykiss, a 24 h phenylhydrazine treatment was used to reduce haematocrit to almost one third of its initial value over 4-5 days. In response, relative blood velocity in the ventral aorta (an index of cardiac output) progressively increased to more than double to its normocythaemic value and there was no significant change in routine oxygen uptake. Thus, the primary compensatory response to anaemia was an increase in cardiac output...
October 2015: Journal of Fish Biology
Johannes G Krabbe, Evelien W M Kemna, Annuska L M Strunk, Pieter A Jobse, P A Kramer, L D Dikkeschei, L P W J van den Heuvel, Rob Fijnheer, Leo F Verdonck
Thrombotic thrombocytopenic purpura (TTP) is a life-threatening disease, characterized by microangiopathic hemolytic anaemia and thrombocytopenia, resulting in neurologic and/or renal abnormalities. We report a 49-year-old patient with a history of thrombotic events, renal failure, and thrombocytopenia. Blood analysis demonstrated no ADAMTS13 activity in the absence of antibodies against ADAMTS13. The complete ADAMTS13 gene was sequenced, and two mutations were identified: one mutation on exon 24 (Arg1060Asp), which had previously been described, and a mutation on exon 27 (Met1260IlefsX34), which has not been reported...
October 2015: International Journal of Hematology
Alexander J Hamilton, Lynsey H Webb, Jennifer K Williams, Richard J D'Souza, Loretta S P Ngu, Jason Moore
BACKGROUND: Autoimmune haemolytic anaemia (AIHA) is a rare complication following kidney transplantation and usually occurs early in its course. It is characterised by autoantibodies or alloantibodies directed against red blood cells (RBCs). CASE PRESENTATION: We describe a 44 year old woman who presented 5 years after kidney transplantation with profound transfusion dependent warm AIHA. Investigations confirmed an IgG autoantibody against RBCs and high titre Epstein-Barr virus (EBV) viraemia...
2015: BMC Nephrology
J A Cartwright, D J Gow, A G Gow, I Handel, N Reed, A J Brown, R Cash, A Foote, D Mackenzie, R Bell, R J Mellanby
OBJECTIVES: The measurement of serum cardiac troponin I concentrations in dogs with a range of non-primary cardiac illnesses suggests that cardiac myocyte damage is commonplace. Dogs with primary immune-mediated haemolytic anaemia have increased serum cardiac troponin I concentrations at the time of diagnosis. However, it is unclear whether biochemical evidence of cardiac myocyte damage improves following successful treatment of anaemia. METHODS: A haematology profile was performed and serum cardiac troponin I concentrations were measured in 19 dogs with primary immune-mediated haemolytic anaemia before and after treatment...
August 2015: Journal of Small Animal Practice
Katherine Plewes, Md Shafiul Haider, Hugh W F Kingston, Tsin W Yeo, Aniruddha Ghose, Md Amir Hossain, Arjen M Dondorp, Gareth D H Turner, Nicholas M Anstey
BACKGROUND: Severe falciparum malaria may be complicated by haemolysis after parasite clearance, however the mechanisms remain unclear. Recent reports describe a pattern of delayed onset haemolysis among non-immune travellers with hyperparasitaemia treated with intravenous artesunate, termed post-artesunate delayed haemolysis (PADH). The occurrence and clinical impact of PADH following severe malaria infections in areas of unstable transmission are unknown. CASE: A 45-year-old Bangladeshi male was initially admitted to a local hospital with severe falciparum malaria complicated by hyperparasitaemia and treated with intravenous artesunate...
2015: Malaria Journal
Hermann S Füeßl
No abstract text is available yet for this article.
March 26, 2015: MMW Fortschritte der Medizin
Hsiang-Ying Lee, Xiaofei Gao, M Inmaculada Barrasa, Hu Li, Russell R Elmes, Luanne L Peters, Harvey F Lodish
Many acute and chronic anaemias, including haemolysis, sepsis and genetic bone marrow failure diseases such as Diamond-Blackfan anaemia, are not treatable with erythropoietin (Epo), because the colony-forming unit erythroid progenitors (CFU-Es) that respond to Epo are either too few in number or are not sensitive enough to Epo to maintain sufficient red blood cell production. Treatment of these anaemias requires a drug that acts at an earlier stage of red cell formation and enhances the formation of Epo-sensitive CFU-E progenitors...
June 25, 2015: Nature
Sarah Case, Thomas J Johnston, Michael O'Sullivan, Will Thomas, Oliver J Wiseman
No abstract text is available yet for this article.
2015: BMJ: British Medical Journal
Alice Wolfromm, Christophe Rodriguez, Marc Michel, Anoosha Habibi, Vincent Audard, Emmanuel Benayoun, Olivier Rogier, Dominique Challine, Olivier Chosidow, Jean-Daniel Lelièvre, Xavier Chevalier, Fabien Le Bras, Cécile Pautas, Michèle Imbert, Jean-Michel Pawlotsky, Orianne Wagner-Ballon
The virological diagnosis of Parvovirus B19 (PvB19) infection is currently based on sero-diagnosis, molecular methods or both, yet without clear recommendations. We retrospectively identified patients with polymerase chain reaction-positive PvB19 and/or positive serological assay between 2007 and 2013. Eighty-two adults with at least one diagnostic criterion of recent PvB19 infection (IgM antibodies, viral DNA in blood and/or in marrow) were included and classified into three homogeneous groups: 30 patients had no underlying predisposing condition, 25 a hereditary haemolytic anaemia, 27 an underlying immunodeficiency...
July 2015: British Journal of Haematology
Gouranga Santra, Rudrajit Paul, Partha Sarathi Choudhury, Sumit Kr Ghosh, Dibyendu De, Shubhabrata Das
Wilson's disease can have different manifestations like jaundice, cirrhosis of liver, extrapyramidal symptoms and dementia. Haemolytic anaemia may occur but it is commonly associated with florid manifestation of liver disease. Sometimes, liver cell necrosis can release huge free copper ions in blood, giving rise to oxidant damage to erythrocytes. Oxidative damage to cell membrane, haemoglobin and erythrocyte metabolism causes haemolytic crisis. In some cases, liver involvement is subclinical, but nonetheless, free copper is released from necrosed hepatocytes and causes oxidative damage to erythrocytes...
October 2014: Journal of the Association of Physicians of India
Dhwanee Thakkar, Nita Radhakrishnan, P K Pruthi, Anupam Sachdeva
BACKGROUND: Association of autoimmune haemolytic anaemia has been seldom reported with Kawasaki disease. CASE CHARACTERISTICS: A 7-month-old boy, presented with prolonged fever, erythematous rash, severe pallor and hepatosplenomegaly. OBSERVATIONS: Positive Direct Coombs test and coronary artery aneurysm on echocardiography. He was managed with steroids along with intravenous immunoglobulins and aspirin. OUTCOME: Early identification of the condition helped in the management...
March 8, 2015: Indian Pediatrics
S S Ke, G A Anderson, S L Connolly
OBJECTIVE: Apply a previously described scoring system retrospectively to cases of canine primary immune-mediated haemolytic anaemia (pIMHA) to determine its accuracy and reliability for the determination of prognosis in Victoria, Australia. METHODS: Retrospective cohort study of 41 dogs diagnosed with pIMHA at the University of Melbourne Veterinary Hospital (UMVH) between August 2006 to December 2012. RESULTS: Of the 41 dogs included, 70...
April 2015: Australian Veterinary Journal
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