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https://www.readbyqxmd.com/read/29169174/melatonin-induced-changes-in-cytosolic-calcium-might-be-responsible-for-apoptosis-induction-in-tumour-cells
#1
Barbora Chovancova, Sona Hudecova, Lubomira Lencesova, Petr Babula, Ingeborg Rezuchova, Adela Penesova, Marian Grman, Roman Moravcik, Michal Zeman, Olga Krizanova
BACKGROUND/AIMS: Melatonin is a hormone transferring information about duration of darkness to the organism and is known to modulate several signaling pathways in the cells, e.g. generation of endoplasmic reticulum stress, oxidative status of the cells, etc. Melatonin has been shown to exert antiproliferative and cytotoxic effects on various human cancers. We proposed that this hormone can differently affect tumour cells and healthy cells. METHODS: We compared the effect of 24 h melatonin treatment on calcium transport (by fluorescent probes FLUO-3AM and Rhod-5N), ER stress (determined as changes in the expression of CHOP, XBP1 and fluorescently, using Thioflavin T), ROS formation (by CellROX® Green/Orange Reagent) and apoptosis induction (by Annexin-V-FLUOS/propidiumiodide) in two tumour cell lines - ovarian cancer cell line A2780 and stable cell line DLD1 derived from colorectal carcinoma, with non-tumour endothelial cell line EA...
November 23, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29169125/functional-connectivity-between-salience-default-mode-and-frontoparietal-networks-in-post-stroke-depression
#2
Vladislav Balaev, Ivan Orlov, Alexey Petrushevsky, Olga Martynova
BACKGROUND: Previous studies have demonstrated altered resting state functional connectivity (rsFC) in patients with post-stroke depression (PSD). It remains unclear whether rsFC is changed at the network level as was shown for major depressive disorder (MDD). To address this question, we investigated rsFC of resting sate networks (RSNs) in PSD. METHODS: Eleven subjects with PSD underwent fMRI scanning at rest before and after treatment. The severity of depression was assessed using the aphasic depression rating scale (ADRS)...
November 13, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29168976/biological-therapies-in-psoriasis-revisited
#3
Maria-Isabela Sârbu, Simona-Roxana Georgescu, Mircea Tampa, Alexandra-Elena Sârbu, Olga Simionescu
Psoriasis is a chronic, immune mediated disorder affecting approximately 2% of the population. Even in our days, patients with psoriasis are confronted with stigmatization and social rejection. As a result, their quality of life is significantly impaired. Biological therapies have revolutionized the treatment of moderate to severe psoriasis. The aim of this paper is to look over the most important biological therapies available for the management of plaque-type psoriasis.
November 27, 2017: Romanian Journal of Internal Medicine, Revue Roumaine de Médecine Interne
https://www.readbyqxmd.com/read/29168784/optimization-of-the-use-of-his%C3%A2-oph-based-enzymatic-biocatalysts-for-the-destruction-of-chlorpyrifos-in-soil
#4
Olga Senko, Olga Maslova, Elena Efremenko
Applying enzymatic biocatalysts based on hexahistidine-containing organophosphorus hydrolase (His₆-OPH) is suggested for the decomposition of chlorpyrifos, which is actively used in agriculture in many countries. The application conditions were optimized and the following techniques was suggested to ensure the highest efficiency of the enzyme: first, the soil is alkalinized with hydrated calcitic lime Ca(OH)₂, then the enzyme is introduced into the soil at a concentration of 1000 U/kg soil. Non-equilibrium low temperature plasma (NELTP)-modified zeolite is used for immobilization of the relatively inexpensive polyelectrolyte complexes containing the enzyme His₆-OPH and a polyanionic polymer: poly-l-glutamic acid (PLE50) or poly-l-aspartic acid (PLD50)...
November 23, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29168754/a-bioinformatic-pipeline-for-monitoring-of-the-mutational-stability-of-viral-drug-targets-with-deep-sequencing-technology
#5
Yuri Kravatsky, Vladimir Chechetkin, Daria Fedoseeva, Maria Gorbacheva, Galina Kravatskaya, Olga Kretova, Nickolai Tchurikov
The efficient development of antiviral drugs, including efficient antiviral small interfering RNAs (siRNAs), requires continuous monitoring of the strict correspondence between a drug and the related highly variable viral DNA/RNA target(s). Deep sequencing is able to provide an assessment of both the general target conservation and the frequency of particular mutations in the different target sites. The aim of this study was to develop a reliable bioinformatic pipeline for the analysis of millions of short, deep sequencing reads corresponding to selected highly variable viral sequences that are drug target(s)...
November 23, 2017: Viruses
https://www.readbyqxmd.com/read/29168748/variety-and-dynamics-of-proteoforms-in-the-human-proteome-aspects-of-markers-for-hepatocellular-carcinoma
#6
Stanislav Naryzhny, Victor Zgoda, Artur Kopylov, Elena Petrenko, Olga Kleist, Аlexander Archakov
We have previously developed an approach, where two-dimensional gel electrophoresis (2DE) was used, followed by sectional analysis of the whole gel using high-resolution nano-liquid chromatography-mass spectrometry (ESI LC-MS/MS). In this study, we applied this approach on the panoramic analysis of proteins and their proteoforms from normal (liver) and cancer (HepG2) cells. This allowed us to detect, in a single proteome, about 20,000 proteoforms coded by more than 4000 genes. A set of 3D-graphs showing distribution of these proteoforms in 2DE maps (profiles) was generated...
November 23, 2017: Proteomes
https://www.readbyqxmd.com/read/29168740/dietary-intake-of-cadmium-lead-and-mercury-and-its-association-with-bone-health-in-healthy-premenopausal-women
#7
Jesus M Lavado-García, Luis M Puerto-Parejo, Raul Roncero-Martín, Jose M Moran, Juan D Pedrera-Zamorano, Ignacio J Aliaga, Olga Leal-Hernández, Maria L Canal-Macias
The bone is one of the relevant target organs of heavy metals, and heavy metal toxicity is associated with several degenerative processes, such osteoporosis and bone mineral alterations, that could lead to fractures. We aimed to study a presumed relationship between bone density, evaluated by quantitative bone ultrasound (QUS), dual-energy X-ray absorptiometry (DXA) and peripheral quantitative computed tomography (pQCT) and the dietary intake of cadmium, lead and mercury in healthy premenopausal women. A total of 158 healthy, non-smoking, premenopausal women were incorporated into the study...
November 23, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29168035/prevalence-and-correlates-of-high-fear-of-cancer-recurrence-in-late-adolescents-and-young-adults-consulting-a-specialist-adolescent-and-young-adult-aya-cancer-service
#8
Belinda Thewes, Suzanne E J Kaal, Jose A E Custers, Eveliene Manten-Horst, Rosemarie Jansen, Petra Servaes, Winette T A van der Graaf, Judith B Prins, Olga Husson
OBJECTIVE: High fear of cancer recurrence (FCR) is a frequently reported problem among cancer patients. Previous research has shown that younger age is associated with higher levels of FCR. However, little attention has been given to date about how FCR manifests itself among adolescent and young adult (AYA) cancer patients. This study explores the prevalence, correlates of high FCR, and its association with HRQoL in cancer patients in their late adolescence or young adulthood. METHODS: Seventy-three AYA cancer patients, aged 18-35 years at diagnosis, consulted the AYA team of the Radboud University Medical Center completed questionnaires including the Cancer Worry Scale (CWS), Quality of Life-Cancer Survivors (QOL-CS), and Hospital Anxiety and Depression Scale (HADS)...
November 22, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/29167582/pyridoxine-dipharmacophore-derivatives-as-potent-glucokinase-activators-for-the-treatment-of-type-2-diabetes-mellitus
#9
Mikhail S Dzyurkevich, Denis A Babkov, Nikita V Shtyrlin, Olga Yu Mayka, Alfiya G Iksanova, Pavel M Vassiliev, Konstantin V Balakin, Alexander A Spasov, Vadim V Tarasov, George Barreto, Yurii G Shtyrlin, Gjumrakch Aliev
Glucokinase is one of the promising targets for glucose-lowering agents, and the development of GK activators are now considered as one of the most promising strategies for the treatment of type 2 diabetes mellitus. In this work, a series of novel symmetric molecular constructs, in which two pyridoxine moieties are connected via sulfur-containing linkers, have been synthesized and tested in vitro for glucokinase activation potential. The enzyme activation rates by two most active compounds at 100 μM (~150% and 130%) were comparable to that of the reference agent PF-04937319 (~154%)...
November 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29167354/advances-in-imaging-plant-cell-dynamics
#10
Jozef Samaj, George Komis, Dominik Novak, Miroslav Ovecka, Olga Samajova
No abstract text is available yet for this article.
November 22, 2017: Plant Physiology
https://www.readbyqxmd.com/read/29167252/metagenome-of-the-siberian-underground-water-reservoir
#11
Vitaly V Kadnikov, Yulia A Frank, Andrey V Mardanov, Alexey V Beletsky, Olga V Karnachuk, Nikolai V Ravin
We report on the metagenome of a deep subsurface aquifer in the Tomsk region of Russia, sampled via an oil exploration borehole drilled to a depth of 2.8 km. Methanogenic archaea were present in the water along with members of various bacterial phyla, including Firmicutes, Chloroflexi, Bacteroidetes, Ignavibacteriae, and uncultured candidate divisions.
November 22, 2017: Genome Announcements
https://www.readbyqxmd.com/read/29166634/sodium-prescription-in-the-prevention-of-intradialytic-hypotension-new-insights-into-an-old-concept
#12
Gabriele Donati, Mauro Ursino, Alessandra Spazzoli, Nicolò Natali, Roberto Schillaci, Diletta Conte, Andrea Angeletti, Anna Laura Croci Chiocchini, Irene Capelli, Olga Baraldi, Gaetano La Manna
BACKGROUND: Sodium prescription in patients with intradialytic hypotension remains a challenge for the attending nephrologist, as it increases dialysate conductivity in hypotension-prone patients, thereby adding to dietary sodium levels. METHODS: New sodium prescription strategies are now available, including the use of a mathematical model to compute the sodium mass to be removed during dialysis as a physiological controller. RESULTS: This review describes the sodium load of patients with end-stage renal disease on chronic hemodialysis (HD) and discusses 2 strategies to remove excess sodium in patients prone to intradialytic hypotension, namely, Profiled HD and the hemodiafiltration Aequilibrium System...
November 23, 2017: Blood Purification
https://www.readbyqxmd.com/read/29166132/imaging-of-iatrogenic-esophageal-injuries-using-optimized-ct-esophageal-leak-protocol-pearls-and-pitfalls
#13
Rachna Madan, Olga Laur, Breland Crudup, Latia Peavy, Brett W Carter
Iatrogenic injury to the esophagus is a serious complication which is increasingly seen in clinical practice secondary to expansion and greater acceptability of surgical and endoscopic esophageal procedures. Morbidity and mortality following such injury is high. This is mostly due to an inflammatory response to gastric contents in the mediastinum, and the negative intra-thoracic pressures that may further draw out esophageal contents into the mediastinum leading to mediastinitis. Subsequently, pulmonary complications such as pneumonia or abscess may ensue leading to rapid clinical deterioration...
November 22, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/29166030/dissolution-and-characterization-of-boron-nitride-nanotubes-in-superacid
#14
Olga Kleinerman, Mohammed Adnan, Daniel M Marincel, Anson Wk Ma, E Amram Bengio, Cheol Park, Sang-Hyon Chu, Matteo Pasquali, Yeshayahu Talmon
Boron nitride nanotubes (BNNTs) are of interest for their unique combination of high tensile strength, high electrical resistivity, high neutron cross-section, and low reactivity. The fastest route to employing these properties in composites and macroscopic articles is through solution processing. However, dispersing BNNTs without functionalization or use of a surfactant is challenging. We show here by cryogenic transmission electron microscopy that BNNTs spontaneously dissolve in chlorosulfonic acid as disentangled individual molecules...
November 22, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29165933/transmission-scenarios-of-major-vector-borne-diseases-in-colombia-1990-2016
#15
Julio César Padilla, Fredy Eberto Lizarazo, Olga Lucía Murillo, Fernando Antonio Mendigaña, Edwin Pachón, Mauricio Javier Vera
Introducción. Las enfermedades transmitidas por vectores representan más de 17 % de todas las enfermedades infecciosas y causan anualmente un millón de defunciones a nivel mundial. En Colombia, la malaria, el dengue, la enfermedad de Chagas y las leishmaniasis son condiciones endemoepidémicas persistentes.Objetivo. Determinar el comportamiento epidemiológico de las enfermedades transmitidas por vectores en zonas urbanas y rurales de Colombia entre 1990 y 2016.Materiales y métodos. Se hizo un estudio descriptivo del comportamiento epidemiológico de las principales enfermedades transmitidas por vectores en zonas urbanas y rurales de Colombia entre 1990 y 2016, con la información proveniente de fuentes oficiales secundarias...
March 29, 2017: Biomédica: Revista del Instituto Nacional de Salud
https://www.readbyqxmd.com/read/29165464/analytical-sers-general-discussion
#16
Hannah Aitchison, Javier Aizpurua, Heike Arnolds, Jeremy Baumberg, Steven Bell, Alois Bonifacio, Rohit Chikkaraddy, Paul Dawson, Bart de Nijs, Volker Deckert, Ines Delfino, Giuliana Di Martino, Olga Eremina, Karen Faulds, Augustus Fountain, Sylwester Gawinkowski, Mayte Gomez Castano, Roy Goodacre, Jennifer Gracie, Duncan Graham, Jason Guicheteau, Laurence Hardwick, Mike Hardy, Christian Heck, Lauren Jamieson, Marlous Kamp, Alex Keeler, Christian Kuttner, Judith Langer, Sumeet Mahajan, Natalia Martín Sabanés, Kei Murakoshi, Marc Porter, George Schatz, Sebastian Schlücker, Zhongqun Tian, Ashish Tripathi, Richard Van Duyne, Peter Vikesland
No abstract text is available yet for this article.
November 22, 2017: Faraday Discussions
https://www.readbyqxmd.com/read/29165333/pressure-for-pattern-specific-intertypic-recombination-between-sabin-polioviruses-evolutionary-implications
#17
Ekaterina Korotkova, Majid Laassri, Tatiana Zagorodnyaya, Svetlana Petrovskaya, Elvira Rodionova, Elena Cherkasova, Anatoly Gmyl, Olga E Ivanova, Tatyana P Eremeeva, Galina Y Lipskaya, Vadim I Agol, Konstantin Chumakov
Complete genomic sequences of a non-redundant set of 70 recombinants between three serotypes of attenuated Sabin polioviruses as well as location (based on partial sequencing) of crossover sites of 28 additional recombinants were determined and compared with the previously published data. It is demonstrated that the genomes of Sabin viruses contain distinct strain-specific segments that are eliminated by recombination. The presumed low fitness of these segments could be linked to mutations acquired upon derivation of the vaccine strains and/or may have been present in wild-type parents of Sabin viruses...
November 22, 2017: Viruses
https://www.readbyqxmd.com/read/29165077/physicochemical-and-toxic-properties-of-novel-genipin-drug-delivery-systems-prepared-by-mechanochemistry
#18
Wenhao Xu, Murong Wen, Weike Su, Alexander V Dushkin, Lubov P Suntsova, Irina D Markova, Olga Yu Selyutina, Nikolay E Polyakov
Complexes of Genipin and differents water-soluble adjuvant polysaccharides such as arabinogalactane, hydroxyethyl starch, fibergum,and oligosaccharides β-CD and HP-β-CD,were synthesized as drug delivery system using mechanochemical technology. We have investigated physicochemical properties, stability, and hepatotoxicity of the synthesized complexes in solid state and aqueous solution. The formation of the complexes was evidenced by different physical and spectroscopy assays, and the stability constants of our synthesized Genipin-based complexes were also calculated...
November 20, 2017: Current Drug Delivery
https://www.readbyqxmd.com/read/29164972/molecular-subtyping-of-breast-cancer-improves-identification-of-both-high-and-low-risk-patients
#19
Maria Rossing, Olga Østrup, Wiktor W Majewski, Savvas Kinalis, Maj-Britt Jensen, Ann Knoop, Niels Kroman, Maj-Lis Talman, Thomas V O Hansen, Bent Ejlertsen, Finn C Nielsen
BACKGROUND: Transcriptome analysis enables classification of breast tumors into molecular subtypes that correlate with prognosis and effect of therapy. We evaluated the clinical benefits of molecular subtyping compared to our current diagnostic practice. MATERIALS AND METHODS: Molecular subtyping was performed on a consecutive and unselected series of 524 tumors from women with primary breast cancer (n = 508). Tumors were classified by the 256 gene expression signature (CIT) and compared to conventional immunohistochemistry (IHC) procedures...
November 22, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/29164790/comparative-study-of-fatty-acids-profile-in-eleven-wild-mushrooms-of-boletacea-and-russulaceae-families
#20
Marija V Dimitrijevic, Violeta D Mitic, Olga P Jovanovic, Vesna P Stankov Jovanovic, Jelena S Nikolic, Goran M Petrovic, Gordana S Stojanovic
Eleven species of wild mushrooms which belong to Boletaceae and Russulaceae families were examined by gas chromatography (GC) and gas chromatography-mass spectrometry (GC-MS) analysis for the presence of fatty acids. As far as we know, the fatty acid profiles of B. purpureus and B. rhodoxanthus were described for the first time. Twenty-six fatty acids were determined. Linoleic (19.5 - 72%), oleic (0.11 - 64%), palmitic (5.9 - 22%) and stearic acids (0.81 - 57%) were present in the highest contents. In all samples, unsaturated fatty acids dominate...
November 21, 2017: Chemistry & Biodiversity
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