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https://www.readbyqxmd.com/read/28102610/outcomes-of-hiv-positive-patients-lost-to-follow-up-in-african-treatment-programs
#1
REVIEW
Kathrin Zürcher, Anne Mooser, Nanina Anderegg, Olga Tymejczyk, Margaret J Couvillon, Denis Nash, Matthias Egger
OBJECTIVE: The retention of patients on antiretroviral therapy (ART) is key to achieving global targets in response to the HIV epidemic. Loss to follow-up (LTFU) can be substantial, with unknown outcomes for patients lost to ART programs. We examined changes in outcomes of patients LTFU over calendar time, assessed associations with other studies and program characteristics, and investigated the relative success of different tracing methods. METHODS: We performed a systematic review and logistic random-effects meta-regression analysis of studies that traced adults or children who started ART and were LTFU in sub-Saharan African treatment programs...
January 19, 2017: Tropical Medicine & International Health: TM & IH
https://www.readbyqxmd.com/read/28102082/characterization-of-the-molecular-mechanisms-underlying-the-chronic-phase-of-stroke-in-a-cynomolgus-monkey-model-of-induced-cerebral-ischemia
#2
Henry C H Law, Samuel S W Szeto, Quan Quan, Yun Zhao, Zaijun Zhang, Olga Krakovska, Leong Ting Lui, Chengyou Zheng, Simon Ming Yuen Lee, K W Michael Siu, Yuqiang Wang, Ivan K Chu
Stroke is one of the main causes of mortality and long-term disability worldwide. The pathophysiological mechanisms underlying this disease are not well understood, particularly in the chronic phase after the initial ischemic episode. In this study, a Macaca fascicularis stroke model consisting of two sample groups, as determined by MRI-quantified infarct volumes as a measure of the stroke severity 28 days after the ischemic episode, was evaluated using qualitative and quantitative proteomics analyses. By using multiple online multidimensional liquid chromatography platforms, 8790 non-redundant proteins that condensed to 5223 protein groups at 1% global false discovery rate (FDR)...
January 19, 2017: Journal of Proteome Research
https://www.readbyqxmd.com/read/28101847/off-target-anti-inflammatory-activity-of-the-p2x7-receptor-antagonist-az11645373
#3
Olga V Oskolkova, Viktoria Godschachner, Valery N Bochkov
We have found that a well-characterized P2X7 receptor antagonist AZ11645373 blocked production of pro-inflammatory chemokine IL-8 in endothelial cells treated with OxPAPC. The effect was not due to toxicity of AZ11645373 as documented by cellular metabolic activity assay. The mechanism of inhibition by AZ11645373 was apparently independent of the P2X7 receptor because this receptor was not involved in induction of IL-8 under our experimental conditions. In support of this notion, two P2X7 agonists ATP and BzATP did not upregulate IL-8...
January 19, 2017: Inflammation
https://www.readbyqxmd.com/read/28101143/clinical-aspects-of-pancreatogenic-diabetes-secondary-to-hereditary-pancreatitis
#4
Marcio Garrison Dytz, Pedro Arthur Hamamoto Marcelino, Olga de Castro Santos, Lenita Zajdenverg, Flavia Lucia Conceição, Tânia Maria Ortiga-Carvalho, Melanie Rodacki
BACKGROUND: Hereditary pancreatitis is a rare inherited form of pancreatitis, characterized by recurrent episodes of acute pancreatitis with early onset and/or chronic pancreatitis, and presenting brittle diabetes, composed of episodes of nonketotic hyperglycemia and severe hypoglycemia. The existing literature regarding this form of diabetes is scarce. In this report, clinical features of pancreatogenic diabetes secondary to hereditary pancreatitis are presented along with recommendations for appropriate medical treatment...
2017: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/28100849/the-role-genes-encoding-of-killer-cell-immunoglobulin-like-receptors-kirs-and-their-ligands-in-susceptibility-to-and-progression-of-hiv-infection
#5
Olga Błachowicz, Katarzyna Zwolińska
NK cells are a part of the innate antiviral response. Their activity is regulated by signals from the surface receptors. Some of them, known as killer cell immunoglobulin-like receptors (KIRs), determine the quality and intensity of the immunological response, together with their ligands (HLA class I). KIR genes are very polymorphic, and this is reflected in the NK activity modulation. The stimulation of NK cells, especially in the early stages of the infection, can reduce the transmission of HIV or slow down the progression of infection...
December 31, 2016: Postȩpy Higieny i Medycyny Doświadczalnej
https://www.readbyqxmd.com/read/28100818/lowland-biotic-attrition-revisited-body-size-and-variation-among-climate-change-winners-and-losers
#6
Jedediah F Brodie, Matthew Strimas-Mackey, Jayasilan Mohd-Azlan, Alys Granados, Henry Bernard, Anthony J Giordano, Olga E Helmy
The responses of lowland tropical communities to climate change will critically influence global biodiversity but remain poorly understood. If species in these systems are unable to tolerate warming, the communities-currently the most diverse on Earth-may become depauperate ('biotic attrition'). In response to temperature changes, animals can adjust their distribution in space or their activity in time, but these two components of the niche are seldom considered together. We assessed the spatio-temporal niches of rainforest mammal species in Borneo across gradients in elevation and temperature...
January 25, 2017: Proceedings. Biological Sciences
https://www.readbyqxmd.com/read/28099035/-let-the-algorithm-do-the-work-reduction-of-hypoglycemia-using-sensor-augmented-pump-therapy-with-predictive-insulin-suspension-smartguard-in-pediatric-type-1-diabetes-patients
#7
Torben Biester, Olga Kordonouri, Martin Holder, Kerstin Remus, Dorothee Kieninger-Baum, Tanja Wadien, Thomas Danne
BACKGROUND: A sensor-augmented insulin pump (SAP) using the MiniMed(®) 640G system with SmartGuard™ technology allows an automatic stop of insulin delivery based on prediction of low glucose levels. Since pediatric patients are particularly prone to hypoglycemia, this device may offer additional protection beyond conventional sensor-augmented therapy. METHODS: This prospective, pediatric multicenter user evaluation assessed 6 weeks of SAP with SmartGuard (threshold setting for hypoglycemia: 70 mg/dL) compared to a preceding period of 2 weeks with SAP only...
January 18, 2017: Diabetes Technology & Therapeutics
https://www.readbyqxmd.com/read/28098939/a-systematic-review-of-economic-evaluations-of-treatments-for-patients-with-epilepsy
#8
REVIEW
Ben F M Wijnen, Ghislaine A P G van Mastrigt, Silvia M A A Evers, Olga Gershuni, Danielle A J E Lambrechts, Marian H J M Majoie, Debby Postulart, Bert A P Aldenkamp, Reina J A de Kinderen
The increasing number of treatment options and the high costs associated with epilepsy have fostered the development of economic evaluations in epilepsy. It is important to examine the availability and quality of these economic evaluations and to identify potential research gaps. As well as looking at both pharmacologic (antiepileptic drugs [AEDs]) and nonpharmacologic (e.g., epilepsy surgery, ketogenic diet, vagus nerve stimulation) therapies, this review examines the methodologic quality of the full economic evaluations included...
January 18, 2017: Epilepsia
https://www.readbyqxmd.com/read/28098298/recent-progress-in-mild-csp-3-h-bond-dehydrogenative-or-mono-oxidative-functionalization
#9
REVIEW
Andrea Gini, Tobias Brandhofer, Olga García Mancheño
Over the past few years, the development of oxidative methodologies towards efficient and selective direct Csp(3)-H bond functionalization processes has attracted tremendous attention from synthetic chemists. However, only a little attention has been given to the key role of the nature of the oxidant. This review aims at providing a brief summary of the recent advances in mild and more benign oxidative Csp(3)-H bond functionalization reactions, which are classified according to the type of oxidation system employed...
January 18, 2017: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/28097734/how-lay-people-understand-and-make-sense-of-personalized-disease-risk-information
#10
Olga C Damman, Nina M M Bogaerts, Maaike J van den Haak, Danielle R M Timmermans
BACKGROUND: Disease risk calculators are increasingly web-based, but previous studies have shown that risk information often poses problems for lay users. OBJECTIVE: To examine how lay people understand the result derived from an online cardiometabolic risk calculator. DESIGN: A qualitative study was performed, using the risk calculator in the Dutch National Prevention Program for cardiometabolic diseases. The study consisted of three parts: (i) attention: completion of the risk calculator while an eye tracker registered eye movements; (ii) recall: completion of a recall task; and (iii) interpretation: participation in a semi-structured interview...
January 17, 2017: Health Expectations: An International Journal of Public Participation in Health Care and Health Policy
https://www.readbyqxmd.com/read/28097389/observation-time-after-outpatient-non-arterial-interventional-procedures-standards-safety-and-outcomes
#11
Christine K Chen, Johannes Boos, Ammar Sarwar, Bridget O'Bryan-Alberts, Muneeb Ahmed, Olga R Brook
PURPOSE: To evaluate the impact of standardized reduced post-procedure observation time on subsequent healthcare encounters such as emergency department (ED) visits, hospital admissions, and clinic visits. METHODS: 800 consecutive patients undergoing outpatient non-arterial interventional radiologic procedures within the vascular interventional department between 1 June 2013 and 21 July 2014 were included in this IRB-approved, HIPAA-compliant single center observational retrospective study...
January 17, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/28097184/kif6-719arg-genetic-variant-and-risk-for-thoracic-aortic-dissection
#12
Olga A Iakoubova, Carmen H Tong, Joseph Catanese, Charles M Rowland, May M Luke, Maryann Tranquilli, John A Elefteriades
BACKGROUND: Carriers of the 719Arg variant in KIF6, compared with noncarriers, have been reported to be at greater risk for coronary heart disease (CHD) in six prospective studies. Because CHD, thoracic aortic dissection, and nondissection thoracic aortic aneurysm share some risk factors and aspects of pathophysiology, we investigated whether carriers of the 719Arg variant also have greater odds of thoracic aortic dissection or nondissected thoracic aortic aneurysm than noncarriers. METHODS: We genotyped 140 thoracic aortic dissection cases, 497 nondissection thoracic aortic aneurysm cases, and 275 disease-free controls collected in the United States, Hungary, and Greece and investigated the association between KIF6 719Arg carrier status and thoracic aortic dissection, and between KIF6 719Arg carrier status and nondissection thoracic aortic aneurysm, using logistic regression models adjusted for age, sex, hypertension, smoking, and country...
June 2016: Aorta (Stamford, Conn.)
https://www.readbyqxmd.com/read/28096349/structure-of-eukaryotic-cmg-helicase-at-a-replication-fork-and-implications-to-replisome-architecture-and-origin-initiation
#13
Roxana Georgescu, Zuanning Yuan, Lin Bai, Ruda de Luna Almeida Santos, Jingchuan Sun, Dan Zhang, Olga Yurieva, Huilin Li, Michael E O'Donnell
The eukaryotic CMG (Cdc45, Mcm2-7, GINS) helicase consists of the Mcm2-7 hexameric ring along with five accessory factors. The Mcm2-7 heterohexamer, like other hexameric helicases, is shaped like a ring with two tiers, an N-tier ring composed of the N-terminal domains, and a C-tier of C-terminal domains; the C-tier contains the motor. In principle, either tier could translocate ahead of the other during movement on DNA. We have used cryo-EM single-particle 3D reconstruction to solve the structure of CMG in complex with a DNA fork...
January 17, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28095492/growth-hormone-deficiency-is-associated-with-worse-cardiac-function-physical-performance-and-outcome-in-chronic-heart-failure-insights-from-the-t-o-s-ca-ghd-study
#14
Michele Arcopinto, Andrea Salzano, Francesco Giallauria, Eduardo Bossone, Jörgen Isgaard, Alberto M Marra, Emanuele Bobbio, Olga Vriz, David N Åberg, Daniele Masarone, Amato De Paulis, Lavinia Saldamarco, Carlo Vigorito, Pietro Formisano, Massimo Niola, Francesco Perticone, Domenico Bonaduce, Luigi Saccà, Annamaria Colao, Antonio Cittadini
BACKGROUND: Although mounting evidence supports the concept that growth hormone (GH) deficiency (GHD) affects cardiovascular function, no study has systematically investigated its prevalence and role in a large cohort of chronic heart failure (CHF) patients. Aim of this study is to assess the prevalence of GHD in mild-to-moderate CHF and to explore clinical and functional correlates of GHD. METHODS: One-hundred thirty CHF patients underwent GH provocative test with GHRH+arginine and accordingly categorized into GH-deficiency (GHD, n = 88, age = 61...
2017: PloS One
https://www.readbyqxmd.com/read/28095415/klk5-and-klk7-ablation-fully-rescues-lethality-of-netherton-syndrome-like-phenotype
#15
Petr Kasparek, Zuzana Ileninova, Olga Zbodakova, Ivan Kanchev, Oldrich Benada, Karel Chalupsky, Maria Brattsand, Inken M Beck, Radislav Sedlacek
Netherton syndrome (NS) is a severe skin disease caused by the loss of protease inhibitor LEKTI, which leads to the dysregulation of epidermal proteases and severe skin-barrier defects. KLK5 was proposed as a major protease in NS pathology, however its inactivation is not sufficient to rescue the lethal phenotype of LEKTI-deficient mice. In this study, we further elucidated the in vivo roles of the epidermal proteases in NS using a set of mouse models individually or simultaneously deficient for KLK5 and KLK7 on the genetic background of a novel NS-mouse model...
January 17, 2017: PLoS Genetics
https://www.readbyqxmd.com/read/28095351/level-of-granzyme-b-positive-t-regulatory-cells-is-a-strong-predictor-biomarker-of-acute-graft-versus-host-disease-after-day-30-after-allo-hsct
#16
Mikhail Y Drokov, Julia O Davydova, Larisa A Kuzmina, Irina V Galtseva, Nikolay M Kapranov, Vera A Vasilyeva, Darya S Dubnyak, Olga M Koroleva, Ekaterina D Mikhalcova, Natalia N Popova, Elena N Parovichnikova, Valery G Savchenko
Acute Graft-versus-host-disease (aGVHD), the major complication and one of the main causes of poor outcomes of allogeneic hematopoietic stem cell transplantation (allo-HSCT). Nowadays there are no widely accepted cell, plasma or another biomarker that can be used for aGVHD prediction. We hypothesized that a level of Granzyme B-positive T regulatory (GZMB-positive Treg) cells on day+30 after allo-HSCT could be the measure of immune response suppression and could predict aGVHD development after day +30. We applied a widespread and easy-to-perform method of multicolor flow cytometry to measure level of GZMB-positive Treg cells...
January 10, 2017: Leukemia Research
https://www.readbyqxmd.com/read/28095151/health-related-quality-of-life-in-adolescent-and-young-adult-patients-with-cancer-a-longitudinal-study
#17
Olga Husson, Brad J Zebrack, Rebecca Block, Leanne Embry, Christine Aguilar, Brandon Hayes-Lattin, Steve Cole
Purpose To examine changes in health-related quality of life (HRQoL) and its predictors during the first 2 years after initial cancer diagnosis in adolescent and young adult (AYA) patients with cancer. Patients and Methods A multicenter, longitudinal, prospective study was conducted among a diverse sample of AYA patients with cancer ages 15 to 39 years. One hundred seventy-six patients (75% response) completed a self-report measure of HRQoL (Short Form-36 [SF-36]) within the first 4 months after diagnosis and again 12 and 24 months later...
January 17, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28094318/hydrogen-reduction-of-molybdenum-oxide-at-room-temperature
#18
Andreas Borgschulte, Olga Sambalova, Renaud Delmelle, Sandra Jenatsch, Roland Hany, Frank Nüesch
The color changes in chemo- and photochromic MoO3 used in sensors and in organic photovoltaic (OPV) cells can be traced back to intercalated hydrogen atoms stemming either from gaseous hydrogen dissociated at catalytic surfaces or from photocatalytically split water. In applications, the reversibility of the process is of utmost importance, and deterioration of the layer functionality due to side reactions is a critical challenge. Using the membrane approach for high-pressure XPS, we are able to follow the hydrogen reduction of MoO3 thin films using atomic hydrogen in a water free environment...
January 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28094117/maternal-weight-after-childbirth-versus-aging-related-weight%C3%A2-changes
#19
Olga Yakusheva, Kandice Kapinos, Marianne Weiss
BACKGROUND: Pregnancy weight gain is believed to contribute to female overweight and obesity. However, most studies do not account for the changes in body weight expected to occur as women age. We examined the long-term weight trajectory of childbearing women relative to weight progression that could be expected in the absence of pregnancy. METHODS: From the hospital records of 32,187 women with two births in Wisconsin during 2006 to 2013, we extracted the maternal weight at pregravid, delivery, and subsequent pregravid...
January 13, 2017: Women's Health Issues: Official Publication of the Jacobs Institute of Women's Health
https://www.readbyqxmd.com/read/28093694/comparative-analysis-on-the-effect-of-plantago-species-aqueous-extracts-on-tissue-trace-element-content-in-rats
#20
Evgenia R Gatiatulina, Olga N Nemereshina, Joanna Suliburska, Tejo Prakash Nagaraja, Anastasia A Skalnaya, Alexandr A Nikonorov, Anatoly V Skalny, Alexey A Tinkov
The primary objective of this study is to assess the influence of water extracts of Plantago major L., Plantago lanceolata L., and Plantago maxima Juss. ex Jacq. leaves on tissue trace element content in healthy adult Wistar rats. Twenty-eight female Wistar rats consumed pure drinking water or one of the three aqueous extracts of Plantago for 1 month. The extracts and liver, serum, hair, and adipose tissue of the rats were examined for trace element contents using inductively coupled plasma mass spectrometry...
January 16, 2017: Biological Trace Element Research
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