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pulmonary carcinoma staging

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https://www.readbyqxmd.com/read/29343973/a-patient-with-classic-biphasic-pulmonary-blastoma-harboring-cd74-ros1-fusion-responds-to-crizotinib
#1
Zhaoting Meng, Peng Chen, Fenglin Zang, Ying Liu, Xiaoyan Xu, Yudong Su, Jinliang Chen, Li Lin, Lu Zhang, Tengfei Zhang
Pulmonary blastoma (PB) is a rare aggressive lung malignancy with a poor prognosis. Surgical resection is the treatment of choice for localized disease, and there are no standard treatment guidelines for metastatic PB. Due to its rareness, its molecular profile has not been elucidated. We present the first case of classic biphasic pulmonary blastoma (CBPB) with CD74-ROS1 rearrangement in a 44-year-old Asian female with stage IV disease diagnosed using capture-based ultra-deep targeted sequencing. It has been reported that ROS1 rearranged lung adenocarcinoma and squamous cell carcinoma are sensitive to crizotinib, an ALK/MET/ ROS1 multitargeted tyrosine kinase inhibitor...
2018: OncoTargets and Therapy
https://www.readbyqxmd.com/read/29338327/respiratory-gated-pet-ct-for-pulmonary-lesion-characterisation-promises-and-problems
#2
Russell Frood, Garry McDermott, Andrew Scarsbrook
2-Deoxy-2-(18Fluorine)-fluoro-D-glucose (FDG) positron emission tomography/computed tomography (PET/CT) is an integral part of lung carcinoma staging and frequently used in the assessment of solitary pulmonary nodules. However, a limitation of conventional 3D PET/CT when imaging the thorax is its susceptibility to motion artefact which blurs the signal from the lesion resulting in inaccurate representation of size and metabolic activity. Respiratory gated (4D) PET/CT aims to negate the effects of motion artefact and provide a more accurate interpretation of pulmonary nodules and lymphadenopathy...
January 17, 2018: British Journal of Radiology
https://www.readbyqxmd.com/read/29328439/prognostic-significance-of-hypoxia-inducible-factor-1%C3%AE-expression-in-patients-with-clear-cell-renal-cell-carcinoma
#3
Shuiqing Wu, Fen Jiang, Hongtao Wu, Yinhuai Wang, Ran Xu, Jian Cao, Qiong Lu, Xuan Zhu, Zhaohui Zhong, Xiaokun Zhao
The prognostic significance of hypoxia inducible factor-1α (HIF-1α) expression in tumors and the levels of preoperative hemoglobin in clear cell renal cell carcinoma (ccRCC), with or without concomitant chronic obstructive pulmonary disease (COPD), was investigated. A total of 128 patients with ccRCC who underwent surgery were analyzed using retrospective methods. Overall survival (OS) and progression free survival (PFS) were analyzed with clinicopathological variables, including preoperative hemoglobin levels, COPD and the levels of HIF‑1α expression, by Kaplan‑Meier survival analysis...
January 9, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29327422/prognosis-and-distribution-of-lymph-nodes-metastases-in-resectable-primary-pulmonary-lymphoepithelioma-like-carcinoma-a-large-cohort-from-a-single-center
#4
Xiangyang Yu, Yingsheng Wen, Rongqing Qin, Yongbin Lin, Xuewen Zhang, Weidong Wang, Yongqiang Chen, Lanjun Zhang
BACKGROUND: Primary pulmonary lymphoepithelioma-like carcinoma is a rare subtype of lung cancer. Until now, the characteristics of lymph nodes metastases in resectable cases have not yet been reported. METHODS: In this study, a total of 87 consecutive patients with primary pulmonary lymphoepithelioma-like carcinoma that received surgical treatment were investigated from October 1999 to August 2016. The clinical and radiological data and follow-up information were extracted from hospital records in detail...
January 12, 2018: Thoracic Cancer
https://www.readbyqxmd.com/read/29320833/-analysis-of-9-cases-of-nodular-type-of-pulmonary-cryptococcosis-with-coexisting-lung-cancer-confirmed-by-pathological-examinations
#5
H Y Li, C Q Lan, H Weng, S X Chen, Q H Lin, J B Huang
Objective: To describe the characteristics of the nodular type of pulmonary cryptococcosis (PC) with coexisting lung cancer. Methods: A total of 9 cases of PC with coexisting lung cancer, admitted to Fuzhou Pulmonary Hospital of Fujian from 1st January 2009 to 31th December 2016, and confirmed by pathological examinations, were studied and the related literature were reviewed. Results: The patients consisted of 1 male and 8 females, with a mean age of (53±10) years (range, 38 to 68 years). Four patients (44...
November 12, 2017: Chinese Journal of Tuberculosis and Respiratory Diseases
https://www.readbyqxmd.com/read/29319036/the-use-of-adaptive-intensity-modulated-radiotherapy-in-the-treatment-of-small-cell-carcinoma-lung-refractory-to-chemotherapy-in-a-patient-with-preexisting-interstitial-lung-disease
#6
Sarthak Tandon, Munish Gairola, Manoj Pal, Archana Aggarwal, Kanika Sharma, Ahmad Masroor Karimi, Avik Mandal, Rajiv Goyal, Ullas Batra, Inderjit Kaur
This is a case report of a 60-year-old diabetic, hypertensive male with a good performance status and a history of bilateral interstitial lung disease with a left upper lobe lung mass diagnosed to be a Stage IIB mixed small-cell/squamous cell carcinoma which was refractory to carboplatin- and etoposide-based chemotherapy. The patient was then taken up for adaptive intensity-modulated radiotherapy with tighter margin under image guidance with a mid-treatment replanning done at 25#. Acute toxicities were assessed weekly and showed no Grade 3 or more reactions...
January 2018: Lung India: Official Organ of Indian Chest Society
https://www.readbyqxmd.com/read/29312773/post-transplant-native-pneumonectomy-for-interstitial-fibrosis-and-small-cell-lung-cancer
#7
Ramon T Li, Sanam Zahedi, Judy Trieu, Alfred S Lea, William J Calhoun, Alexander G Duarte, Jianping Zhao, Ikenna C Okereke
Lung transplantation is a definitive treatment for select patients with end-stage pulmonary disease. Following transplantation, the reported rate of lung cancer is between 1-9% and is associated with a variety of risk factors, including smoking history and chronic immunosuppression. The majority of post-transplant lung cancer reported in the literature is histologically classified as non-small cell lung carcinoma (NSCLC). We report a unique case of early stage small cell lung carcinoma (SCLC) identified in the native lung following single lung transplantation...
December 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29312742/clinical-characteristics-and-outcomes-of-lung-cancer-patients-with-combined-pulmonary-fibrosis-and-emphysema-a-systematic-review-and-meta-analysis-of-13-studies
#8
Chuan Li, Wenwen Wu, Nan Chen, Huizi Song, Tianjian Lu, Zhenyu Yang, Zihuai Wang, Jian Zhou, Lunxu Liu
Background: The characteristic and outcomes of lung cancer patients with combined pulmonary fibrosis and emphysema (CPFE) have long been assessed, but results were controversial. Therefore, we performed a meta-analysis to assess the clinical features and prognosis of lung cancer patients with CPFE. Methods: The databases PubMed, Embase, and Web of Science (updated to October 1, 2017) were searched for eligible studies. Pooled odds ratios (ORs), weighted mean differences (WMD) or hazard ratios (HRs) with 95% confidence intervals (95% CIs) were used to evaluate the clinicopathological characteristics, the short-term outcome after operation and long-term survival of lung cancer patients with CPFE compared with lung cancer patients without CPFE (fibrosis, emphysema, and normal)...
December 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29310482/anaplastic-lymphoma-kinase-alk-rearranged-pulmonary-pleomorphic-carcinoma-successfully-treated-with-crizotinib
#9
Liping Lin, Fuxi Huang, Fang Chen, Yan He, Jiazhu Hu, Xiaolong Cao
Pulmonary pleomorphic carcinoma (PPC) is rare, and the response of patients to conventional chemotherapy is very poor. Here we present a patient with anaplastic lymphoma kinase (ALK)-rearranged advanced PPC treated with crizotinib. Computed tomography revealed a mass in the left upper lung of a nonsmoking 60-year-old woman. Pathological findings using resected tissue were consistent with PPC stage 1A, T1bN0M0. Although the patient received adjuvant radiotherapy, the disease relapsed, quickly progressed, and remained PPC according to analysis of biopsied tissue...
January 1, 2018: Journal of International Medical Research
https://www.readbyqxmd.com/read/29246019/clinicopathological-and-genetic-characteristics-of-pulmonary-large-cell-carcinoma-under-2015-who-classification-a-pilot-study
#10
Renwang Liu, Jinghao Liu, Tao Shi, Xiongfei Li, Dian Ren, Gang Chen, Ying Li, Hongyu Liu, Song Xu, Jun Chen
Pulmonary large cell carcinoma (LCC) was re-defined under the 2015 WHO classification criteria. However, the clinicopathological features and genetic mutation statuses of Chinese LCC patients based on the new classification have rarely been investigated. Twenty-four Chinese surgically resected LCC patients previously diagnosed under the 2004 WHO criteria were re-classified under the 2015 WHO criteria. Genetic analysis was performed using next-generation sequencing of 46 cancer-related genes. The correlation of clinicopathological and genetic data was further analyzed...
November 21, 2017: Oncotarget
https://www.readbyqxmd.com/read/29240878/pulmonary-sarcomatoid-carcinoma-an-analysis-of-a-rare-cancer-from-the-surveillance-epidemiology-and-end-results-database
#11
Mohamed Rahouma, Mohamed Kamel, Navneet Narula, Abu Nasar, Sebron Harrison, Benjamin Lee, Brendon Stiles, Nasser K Altorki, Jeffrey L Port
OBJECTIVES: Pulmonary sarcomatoid carcinoma (PSC) is a rare malignant neoplasm that accounts for a small percentage of non-small-cell lung carcinoma (NSCLC). At least 10% of PSCs has a spindle and/or giant cell component, which is often associated with a poor prognosis. We reviewed the Surveillance, Epidemiology, and End Results (SEER) database for the clinicopathological characteristics and surgical outcomes of PSCs. METHODS: The SEER database (1973-2013) was queried for PSC...
December 11, 2017: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/29207173/microrna%C3%A2-196b-promotes-cell-migration-and-invasion-by-targeting-foxp2-in-hepatocellular-carcinoma
#12
Zhaoxiang Yu, Xiaobo Lin, Ming Tian, Weiping Chang
Accumulating evidence indicates that microRNAs (miRNAs) play important roles in tumorigenesis and metastasis. Recent research has shown that miR‑196b is implicated in metastasis by regulating the migration and invasion of cancer cells. However, the clinical significance of miR‑196b and its role as well as the underlying mechanisms in hepatocellular carcinoma (HCC) remain largely unknown. Here, we detected miR‑196b expression in HCC and matched non-tumor tissues with qRT‑PCR. We found that miR‑196b displayed higher expression in HCC patient tissues and cells...
December 4, 2017: Oncology Reports
https://www.readbyqxmd.com/read/29201450/the-role-of-surgery-in-high-grade-neuroendocrine-tumours-of-the-lung
#13
Stefan Welter, Clemens Aigner, Christian Roesel
High grade lung neuroendocrine tumours are a heterogeneous subtype of pulmonary cancers including small cell lung cancer (SCLC) and large-cell neuroendocrine carcinoma (LCNEC). LCNEC represents approximately 2-3% of lung cancers, whereas SCLC represents 15-20% of lung cancers. Patients with SCLC and LCNEC have a poor prognosis compared with patients with non-small cell lung cancer (NSCLC). LCNEC is treated with primary surgical resection in stages I-II, which is similar to other NSCLCs. Neo-adjuvant treatment in stage III is similar to NSCLC but has not been well studied...
November 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29197520/effects-of-pirfenidone-in-acute-and-sub-chronic-liver-fibrosis-and-an-initiation-promotion-cancer-model-in-the-mouse
#14
Oleksii Seniutkin, Shinji Furuya, Yu-Syuan Luo, Joseph A Cichocki, Hisataka Fukushima, Yuki Kato, Hiromi Sugimoto, Tomoko Matsumoto, Takeki Uehara, Ivan Rusyn
Liver fibrosis results from chronic tissue damage and excessive regeneration with accumulation of extracellular matrix proteins; it is a precursor of liver cirrhosis and hepatocellular carcinoma. Liver fibrosis treatments are primarily directed at inflammation, with few options to combat fibrogenesis. Pirfenidone is a drug approved for idiopathic pulmonary fibrosis and this study was focused on anti-fibrotic and anti-cancer potential of pirfenidone in the liver of male B6C3F1/J mice. In a dose-finding study, mice were treated with CCl4 (0...
November 29, 2017: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/29191607/pik3ca-mutation-as-a-distinctive-genetic-feature-of-non-small-cell-lung-cancer-with-chronic-obstructive-pulmonary-disease-a-comprehensive-mutational-analysis-from-a-multi-institutional-cohort
#15
Kenji Sawa, Yasuhiro Koh, Tomoya Kawaguchi, Satoshi Kambayashi, Kazuhisa Asai, Shigeki Mitsuoka, Tatsuo Kimura, Naruo Yoshimura, Naoki Yoshimoto, Akihito Kubo, Hideo Saka, Akihide Matsumura, Hideki Wanibuchi, Nobuyuki Yamamoto, Noritoshi Nishiyama, Kazuto Hirata
OBJECTIVES: Non-small cell lung cancer (NSCLC) and chronic obstructive pulmonary disease (COPD) have been proposed to have a mutual developmental mechanism, but their association has not been fully understood. We aimed to examine the association of the mutational landscape of NSCLC with co-morbid COPD. MATERIALS AND METHODS: A total of 197 surgical specimens of early stage NSCLC were retrospectively collected from two independent sources, namely, the Japan Molecular Epidemiology for Lung Cancer Study and the Osaka City University Hospital cohort from 2010 to 2013...
October 2017: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/29188355/-resection-concepts-for-early-stage-neuroendocrine-tumors-of-the-lungs-and-bronchi
#16
REVIEW
T Ploenes, C Aigner
BACKGROUND: Neuroendocrine tumors of the lungs are a very inhomogeneous group of malignancies. The surgical treatment should be adapted to the anatomical localization and histological subtype and individualized according to the functional reserve. MATERIAL AND METHODS: We performed a selective review of current literature, which was supplemented by personal experiences. RESULTS: The currently available outcome data are very inhomogeneous and depend on the histological subtype of neuroendocrine pulmonary tumors...
November 29, 2017: Der Chirurg; Zeitschrift Für Alle Gebiete der Operativen Medizen
https://www.readbyqxmd.com/read/29184692/advanced-duodenal-neoplasia-and-carcinoma-in-familial-adenomatous-polyposis-outcomes-of-surgical-management
#17
Fábio Guilherme Campos, Carlos Augusto Real Martinez, Leonardo Alfonso Bustamante Lopez, Danilo Toshio Kanno, Sérgio Carlos Nahas, Ivan Cecconello
Background: In addition to the presence of neoplasia in the colon and rectum, patients with familial adenomatous polyposis (FAP) may develop numerous polyps and carcinoma within the upper gastrointestinal tract. Methods: The aim of the present paper was to review the incidence advanced duodenal polyposis or cancer and their surgical outcomes. A retrospective review of patients' records from our department was performed. Information was retrieved from a prospective collected data, including clinical (gender, age, family history), endoscopic [association with colorectal cancer (CRC), polyposis severity, age at diagnosis] and surgical management (age, time from the index surgery, type of procedure, morbidity)...
October 2017: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/29163656/the-usefulness-of-thoracic-ultrasonography-in-diagnosis-and-staging-of-bronchogenic-carcinoma
#18
Manal R Hafez, Eman Sm Sobh, Sawsan B Elsawy, Omaima I Abo-Elkheir
Aim: To evaluate (1) the usefulness of thoracic ultrasound in diagnosis and staging of bronchogenic carcinoma by comparing lesion detectability between thoracic- ultrasound and computed tomography and (2) the outcome of thoracic-ultrasound-guided biopsy in diagnosing bronchogenic carcinoma. Methods: We conducted a cross-sectional study on 53 patients of confirmed bronchogenic carcinoma. All patients had been investigated by thoracic-ultrasound and chest-computed tomography; data regarding the presence of mass (its size, necrosis), lymph nodes invasion, peritumoural atelectasis, consolidations, pleural effusion, chest wall invasion, and paralysis of the diaphragm were recorded...
November 2017: Ultrasound: Journal of the British Medical Ultrasound Society
https://www.readbyqxmd.com/read/29152116/microrna-526b-servers-as-a-prognostic-factor-and-exhibits-tumor-suppressive-property-by-targeting-sirtuin-7-in-hepatocellular-carcinoma
#19
Xin Liu, Liu Yang, Jianfeng Tu, Wenwei Cai, Meiqi Zhang, Zhangxuan Shou, Yingmin Yao, Qiuran Xu
Recent studies have reported that microRNA-526b (miR-526b) is implicated in the growth and metastasis of cancer cells. However, the clinical significance of miR-526b and its role as well as underlying mechanisms are largely unknown in hepatocellular carcinoma (HCC). Here, we detected miR-526b expression difference between HCC and matched nontumor tissues with qRT-PCR. We found that miR-526b displayed lower expression in HCC patient tissues and cells. Clinical analysis revealed that low miR-526b expression correlated with large tumor size, venous infiltration, advanced tumor-node-metastasis (TNM) stage...
October 20, 2017: Oncotarget
https://www.readbyqxmd.com/read/29142360/abnormal-fluorodeoxyglucose-uptake-in-lung-without-structural-abnormality-on-computed-tomography
#20
Prathyusha Bikkina, Swapna Kotha, Zakir Ali
Fluorodeoxyglucose (FDG) positron emission tomography-computed tomography (PET-CT) is a useful proven imaging modality in the management of many types of cancers. It is being used at various stages of treatment of cancer. Knowledge regarding the physiological biodistribution and false-positive findings should be kept in mind for correct interpretation. Pulmonary FDG uptake can be due to different causes such as infection, inflammation, and metastases which are invariably associated with structural abnormality on CT...
October 2017: Indian Journal of Nuclear Medicine: IJNM: the Official Journal of the Society of Nuclear Medicine, India
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