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malignant phyllodes work up

Aykut Soyder, Füsun Taşkin, Serdar Ozbas
BACKGROUND: The objectives of this study were to determine the frequency of imaging-histological discordance and to compare the frequency of carcinoma between discordant lesions at ultrasound (US)-guided core needle biopsy. MATERIALS AND METHODS: From November 2009 to June 2012, we performed US-guided 14-gauge core needle biopsies on 989 breast lesions in 961 women. We reviewed 58 (5.8%) cases that had imaging-histological discordance after percutaneous breast biopsy and underwent subsequent excisional biopsy...
February 2015: Breast Care
Sonal Varma, Sandra J Shin
Spindle cell lesions arising in the breast represent reactive, benign, and malignant tumors with overlapping morphologic, clinico-radiologic, and immunohistochemical characteristics. Moreover, common entities comprising this subset are usually uncommon entities in overall prevalence. The combination of such diagnostic "disadvantages" can make the practicing pathologist feel uncertain from the onset of encountering such a case. We hope to dispel some of this discomfort by delineating a simple algorithm that provides structure and direction to the diagnostic work-up...
March 2013: Advances in Anatomic Pathology
G Bernardi, G Cavallaro, M Indinnimeo, A Fiore, L Basso, G D'Ermo, G De Toma, A Cavallaro
INTRODUCTION: Breast phyllodes tumors (PT) are uncommon fibroepithelial lesions having potential malignant features. These tumors have characteristic features, like pleomorphism, mitoses and overgrowth of the stroma with possible infiltrative margins. The clinical behaviour could be unpredictable, since the relatively high recurrence rate despite correct surgical strategy. Conventional diagnostic examinations show high sensitivity and specificity, but cannot demonstrate the differences between benign and malignant PT...
March 2012: Il Giornale di Chirurgia
Yifoong Chia, Aye Aye Thike, Poh Yian Cheok, Luke Yong-Zheng Chong, Gary Man-Kit Tse, Puay Hoon Tan
AIM: To determine the frequency, pattern and distribution of stromal keratin expression in phyllodes tumours if any, which may impact diagnostic approaches. METHODS: The clinicopathological features of 109 phyllodes tumours comprising 70 (64.2%) benign, 30 (27.5%) borderline and nine (8.3%) malignant grades were evaluated, and the immunohistochemical expression of a keratin panel (MNF116, 34βE12, CK7, CK14, AE1/3, Cam5.2), p63 and CD34 in their stromal component was assessed...
April 2012: Journal of Clinical Pathology
K J Chepla, B S Armijo, T A Ponsky, H T Soltanian
Giant fibroadenoma is a rare, benign stromal tumor that typically occurs in adolescent women. This rapidly-growing tumor can result in a significant aesthetic and psychosocial morbidity due to gross asymmetry changes in the overlying skin envelope and concerns about malignancy. On initial work-up this lesion must be differentiated from other rare primary breast tumors, including phyllodes tumor, or metastatic disease. Appropriate treatment of giant fibroadenoma requires surgical excision; however, many surgeons are reluctant to perform a concomitant mastopexy or reconstruction at the time of tumor extirpation...
September 2011: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
F Draghi, L Sabolla, R Campani, G Meloni
Phyllodes tumors are rare fibro-epithelial neoplasms; they may be classified as benign, borderline and malignant according to their histologic features of mitotic index, stroma pleomorphism and lesion outline. Their epidemiology is rather different from that of other breast neoplasms, since these lesions most frequently affect white Latin women 45 to 49 years old. The incidence of metastases is strictly correlated with the degree of histologic aggressiveness, although even small lesions, either borderline or with low malignancy, may metastasize...
May 1996: La Radiologia Medica
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