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https://www.readbyqxmd.com/read/28339502/histological-and-anatomical-structure-of-the-nasal-cavity-of-bama-minipigs
#1
Jingjing Yang, Lei Dai, Qinghua Yu, Qian Yang
OBJECTIVE: The nasal mucosa is equipped with abundant lymphatic tissues, serving as the first line of defense against invasion by microorganisms. In this study, we characterized the features of the nasal mucosa of Bama minipigs (Sus scrofa domestica) via histological analysis. METHODS: Five cross sections (I, II, III, IV, and V) were obtained from the distal end of the nasal cavity toward the pharynx (along the cavity axis) and examined. Specifically, CD3+ T cells, immunoglobulin A (IgA)+ cells, and M cells were detected by immunohistochemistry, while dendritic cells (DCs) were detected by immunofluorescence...
2017: PloS One
https://www.readbyqxmd.com/read/28332735/non-hodgkin-lymphoma-in-south-east-asia-an-analysis-of-the-histopathology-clinical-features-and-survival-from-thailand
#2
Tanin Intragumtornchai, Udomsak Bunworasate, Kitsada Wudhikarn, Arnuparp Lekhakula, Jakrawadi Julamanee, Kanchana Chansung, Chittima Sirijerachai, Lalita Norasetthada, Weerasak Nawarawong, Archrob Khuhapinant, Noppadol Siritanaratanakul, Tontanai Numbenjapon, Kannadit Prayongratana, Suporn Chuncharunee, Pimjai Niparuck, Tawatchai Suwanban, Nongluk Kanitsap, Somchai Wongkhantee, Rutchanid Pornvipavee, Peerapon Wong, Nisa Makruasi, Pongsak Wannakrairot, Thamathorn Assanasen, Sanya Sukpanichnant, Paisarn Boonsakan, Wasana Kanoksil, Charin Ya-In, Kanita Kayasut, Winyu Mitranun, Naree Warnnissorn
Systemic reports on the descriptive epidemiology of non-Hodgkin lymphoma (NHL) from Southeast Asia are scarce. A nationwide multi-institutional registry was conducted to compare the histopathology, clinical features, and survival of Thai adult patients with NHL using large registries, especially those from Far East Asia (FEA). Using a web-based registry system, 13 major medical centers from the 4 geographic regions of Thailand prospectively collected, from 2007 to 2014, the diagnostic pathology, according to the World Health Organization classification, 2008, clinical features and survival of 4056 patients who were newly diagnosed with NHL...
March 23, 2017: Hematological Oncology
https://www.readbyqxmd.com/read/28327534/the-anti-allergic-rhinitis-effect-of-traditional-chinese-medicine-of-shenqi-by-regulating-mast-cell-degranulation-and-th1-th2-cytokine-balance
#3
Yang-Yang Shao, Yi-Ming Zhou, Min Hu, Jin-Ze Li, Cheng-Juan Chen, Yong-Jiang Wang, Xiao-Yun Shi, Wen-Jie Wang, Tian-Tai Zhang
Shenqi is a traditional Chinese polyherbal medicine has been widely used for the treatment of allergic rhinitis (AR). The aim of this study was to investigate the anti-allergic rhinitis activity of Shenqi and explore its underlying molecular mechanism. Ovalbumin (OVA)-induced allergic rhinitis rat model was used to evaluate the anti-allergic rhinitis effect of Shenqi. The effect of Shenqi on IgE-mediated degranulation was measured using rat basophilic leukemia (RBL-2H3) cells. Primary spleen lymphocytes were isolated to investigate the anti-allergic mechanism of Shenqi by detecting the expression of transcription factors via Western blot and the level of cytokines (IL-4 and IFN-γ) via ELISA...
March 22, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28322448/superior-turbinate-eosinophilia-correlates-with-olfactory-deficit-in-chronic-rhinosinusitis-patients
#4
Jennifer Lavin, Jin-Young Min, Alcina K Lidder, Julia He Huang, Atsushi Kato, Kent Lam, Eric Meen, Joan S Chmiel, James Norton, Lydia Suh, Mahboobeh Mahdavinia, Kathryn E Hulse, David B Conley, Rakesh K Chandra, Stephanie Shintani-Smith, Robert C Kern, Robert P Schleimer, Bruce K Tan
OBJECTIVE: To evaluate if molecular markers of eosinophilia in olfactory-enriched mucosa are associated with olfactory dysfunction. STUDY DESIGN: Cross-sectional study of tissue biopsies from 99 patients, and an additional 30 patients who underwent prospective olfactory testing prior to sinonasal procedures. METHODS: Tissue biopsies were processed for analysis of inflammatory markers using quantitative real time polymerase chain reaction (qRT-PCR)...
March 21, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28321216/facilitated-peptide-transport-via-the-mucosal-epithelium-impact-on-tolerance-induction
#5
Elisabeth E Kenngott, Jennifer Pfeil, Ute Hoffmann, Uta Lauer, Anja A Kühl, Anne Rigby, Anton Pernthaner, Alf Hamann
A hallmark of autoimmunity is the breakdown of tolerance and generation of effector responses against self-antigens. Re-establishment of tolerance in autoimmune disorders was always the most desired treatment option; however, despite many efforts, clinical trials have been largely unsuccessful. This also applies to the generation of oral tolerance, which seems to be a default response type of the mucosa-associated lymphoid tissues to harmless antigens. In this study, we report improved efficacy of oral tolerance induction by coupling antigen with the newly identified mucosal carrier peptide 13C...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28315627/cytological-evaluation-of-the-nasal-mucosa-in-neonates-exposed-to-tobacco-smoke-during-fetal-life
#6
(no author information available yet)
OBJECTIVES: The objective of this study is to assess the cytological picture of the nasal mucosa of neonates born to mothers who are active smokers, passive smokers and non-smokers. METHODS: A prospective study was conducted in a group of 86 neonates born between 23 and 41 weeks of gestation. The assignation of neonates to one of the three aforementioned groups was based on a questionnaire concerning exposure to tobacco smoke, and on the concentration of cotinine in maternal urine...
November 19, 2016: Neuro Endocrinology Letters
https://www.readbyqxmd.com/read/28315292/hypoxic-culture-promotes-dopaminergic-neuronal-differentiation-of-nasal-olfactory-mucosa-mesenchymal-stem-cells-via-up-regulation-of-hypoxia-inducible-factor-1%C3%AE
#7
Yi Zhuo, Lei Wang, Lite Ge, Xuan Li, Ping Chen, Da Duan, Xiaohua Teng, Miao Jiang, Kai Liu, Ting Yuan, Pei Wu, Hao Wang, Yujia Deng, Huali Xie, Ying Xia, Ming Lu
<p><b>Background</b> Olfactory mucosa mesenchymal stem cells (OM-MSCs) display significant clonogenicactivity and may be easily propagated for Parkinson's disease therapies. Methods of inducing OM-MSCs to differentiate into dopaminergic (DAergic) neurons using olfactory ensheathing cells (OECs) is thus an attractive topic of research.</p><p><b>Methods</b> We designed a hypoxic-induction protocol to generate DAergic neurons from OM-MSCs using a physiological oxygen (O2) level of 3% and OEC-conditioned medium (HI group)...
March 17, 2017: Cell Transplantation
https://www.readbyqxmd.com/read/28295381/upper-lateral-cartilage-composite-flap-for-closure-of-complicated-septal-perforations
#8
David F Smith, Monirah Albathi, Andrew Lee, Linda N Lee, Kofi D Boahene
OBJECTIVES/HYPOTHESIS: To present a novel technique for the repair of large complicated nasal septal perforations using an upper lateral cartilage composite flap. STUDY DESIGN: This is a case series of five patients with large septal perforations seen at an academic tertiary care center, who have failed previous treatment measures and were selected to undergo this novel reconstruction for closure of their defects. METHODS: Patients were followed clinically to determine the success of the repair...
March 14, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28293965/endoscopic-approach-for-a-delayed-post-traumatic-ethmoidal-mucocele-a-technical-note
#9
Mahmoud Messerer, Giulia Cossu, Roy Thomas Daniel
OBJECTIVE: Delayed post-traumatic mucoceles are rare. We describe the surgical treatment of a post-traumatic ethmoidal mucocele with intra-orbital extension. METHOD: A uninostril endoscopic endonasal approach (EEA) was performed. The access was contralateral to the lesion to provide a wider lateral view. After a large sphenoid and ethmoid sinuses opening, the collection was drained and the optic nerve precociously identified. The orbital roof was eroded and the frontal dura mater directly visible...
March 15, 2017: British Journal of Neurosurgery
https://www.readbyqxmd.com/read/28293930/anti-interleukin-9-antibody-increases-the-effect-of-allergen-specific-immunotherapy-in-murine-allergic-rhinitis
#10
Ji Hyeon Shin, Do Hyun Kim, Boo Young Kim, Sung Won Kim, Se Hwan Hwang, Joohyung Lee, Soo Whan Kim
PURPOSE: Interleukin (IL)-9 induces allergic responses; however, the roles of anti-IL-9 antibody in the induction of tolerance remain unclear. This study investigated the effects of anti-IL-9 antibody on oral tolerance (OT) in a mouse model of allergic rhinitis (AR). METHODS: BALB/c mice were divided into 4 groups: the control, AR, OT, and OT with anti-IL-9 antibody (OT+IL9AB) groups. Ovalbumin (OVA) was used for sensitization and challenge. Mice in the OT and OT+IL9AB groups were fed OVA for immunotherapy...
May 2017: Allergy, Asthma & Immunology Research
https://www.readbyqxmd.com/read/28291371/activity-of-multidrug-resistance-associated-proteins-1-5-mrp1-5-in-the-rpmi-2650-cell-line-and-explants-of-human-nasal-turbinate
#11
Anne M Dolberg, Stephan Reichl
The profound influence of ATP-binding cassette (ABC) transporters on the disposition of numerous drugs has led to increased interest in characterizing their expression profiles in various epithelial and endothelial barriers. The present work examined the presence and functional activity of five ABC efflux proteins, i.e. MRP 1 - 5, in freshly isolated human nasal epithelial cells and two in vitro models based on the human RPMI 2650 cell line. To evaluate the expression patterns of MRP1, MRP2, MRP3, MRP4 and MRP5 at the mRNA and protein levels in the ex vivo model and the differently cultured RPMI 2650 cells, reverse transcriptase polymerase chain reaction (RT-PCR), Western blot analysis and indirect immunofluorescence staining were used...
March 14, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/28289401/sleep-disorders-is-the-trigemino-cardiac-reflex-a-missing-link
#12
REVIEW
Tumul Chowdhury, Barkha Bindu, Gyaninder Pal Singh, Bernhard Schaller
Trigeminal innervated areas in face, nasolacrimal, and nasal mucosa can produce a wide array of cardiorespiratory manifestations that include apnea, bradypnea, bradycardia, hypotension, and arrhythmias. This reflex is a well-known entity called "trigemino-cardiac reflex" (TCR). The role of TCR is investigated in various pathophysiological conditions especially in neurosurgical, but also skull base surgery procedures. Additionally, its significance in various sleep-related disorders has also been highlighted recently...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28281209/formulation-and-evaluation-of-thermoreversible-in-situ-nasal-gels-containing-mometasone-furoate-for-allergic-rhinitis
#13
Ebru Altuntaş, Gülgün Yener
The purpose of the present work was to develop a mucoadhesive thermoreversible nasal gel with a tailored gelling temperature to provide the prolonged contact between mometasone furoate and the nasal mucosa and in order to prevent drainage of the formulation. For this purpose, in situ gel containing a thermogelling polymer poloxamer 407 (Pluronic® F-127) and a mucoadhesive polymer Carbopol® 974P NF was prepared. In this content, formulations were designed to have gelation temperature below 34°C to obtain gelation at intranasal cavity...
March 9, 2017: AAPS PharmSciTech
https://www.readbyqxmd.com/read/28279492/group-2-innate-lymphoid-cells-are-recruited-to-the-nasal-mucosa-in-patients-with-aspirin-exacerbated-respiratory-disease
#14
Jacqueline J Eastman, Kellen J Cavagnero, Adam S Deconde, Alex S Kim, Maya R Karta, David H Broide, Bruce L Zuraw, Andrew A White, Sandra C Christiansen, Taylor A Doherty
BACKGROUND: Aspirin-exacerbated respiratory disease (AERD) is characterized by tissue eosinophilia and mast cell activation, including abundant production of prostaglandin D2 (PGD2). Group 2 innate lymphoid cells (ILC2s), which promote tissue eosinophilia and mast cell responses, undergo chemotaxis and cytokine production in response to PGD2, but it is unknown whether ILC2s are active in patients with AERD. OBJECTIVE: We sought to determine whether ILC2 numbers change in peripheral blood and the nasal mucosa during COX-1 inhibitor-induced reactions in patients with AERD...
January 27, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28275474/effects-of-leukotriene-d4-nasal-challenge-on-bronchial-responsiveness-and-inflammation-in-asthmatic-patients-with-allergic-rhinitis
#15
Zheng Zhu, Yanqing Xie, Weijie Guan, Yi Gao, Rongquan Huang, Shu Xia, Wenhua Jian, Zhiyu Liang, Jinping Zheng
BACKGROUND: In asthmatic patients with allergic rhinitis (AR), increased cysteinyl leukotrienes (CysLTs) production in the secretion of nasal mucosa has been associated with greater bronchial hyperresponsiveness (BHR) after nasal allergen challenge. However, the role of CysLTs in eliciting BHR after nasal allergen challenge has not been evaluated. The aim of this study is to evaluate the effect of LTD4 nasal challenge on BHR and inflammation in asthmatic patients with AR. METHODS: In this self-controlled study, fifteen eligible consecutively recruited subjects underwent methacholine (Mch) bronchial provocation test before and 30 minutes after LTD4 nasal provocation test...
February 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28267500/formulation-of-olfactory-targeted-microparticles-with-tamarind-seed-polysaccharide-to-improve-nose-to-brain-transport-of-drugs
#16
Sasi B Yarragudi, Robert Richter, Helen Lee, Greg F Walker, Andrew N Clarkson, Haribalan Kumar, Shakila B Rizwan
Targeted delivery and retention of drug formulations in the olfactory mucosa, the target site for nose-to-brain drug absorption is a major challenge due to the geometrical complexity of the nose and nasal clearance. Recent modelling data indicates that 10μm-sized microparticles show maximum deposition in the olfactory mucosa. In the present study we tested the hypothesis that 10μm-sized mucoadhesive microparticles would preferentially deposit on, and increase retention of drug on, the olfactory mucosa in a novel 3D-printed human nasal-replica cast under simulated breathing...
May 1, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28265747/the-effect-of-allergic-rhinitis-with-positive-skin-prick-test-on-choroidal-thickness
#17
Alper Yenigun, Ahmet Elbay, Remzi Dogan, Orhan Ozturan, Mehmet Hakan Ozdemir
Allergic rhinitis is an inflammatory disease that develops through immunoglobulin E in the rhino-ocular mucosa due to allergy. The main symptoms are runny nose, nasal congestion, sneezing and itchy nose. This study was designed to investigate the effect of allergic rhinitis on choroidal thickness. This study was planned as a case-control study. This study performed in a tertiary referral center. The study included 61 patients with allergic rhinitis and 35 healthy subjects. Patients in both groups underwent skin prick test...
March 6, 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/28259526/review-of-intranasally-administered-medications-for-use-in-the-emergency-department
#18
Abby M Bailey, Regan A Baum, Karolyn Horn, Tameka Lewis, Kate Morizio, Amy Schultz, Kyle Weant, Stephanie N Justice
BACKGROUND: Intranasal (IN) medication delivery is a viable alternative to other routes of administration, including intravenous (IV) and intramuscular (IM) administration. The IN route bypasses the risk of needle-stick injuries and alleviates the emotional trauma that may arise from the insertion of an IV catheter. OBJECTIVE: This review aims to evaluate published literature on medications administered via the IN route that are applicable to practice in emergency medicine...
March 1, 2017: Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28258963/interferon-%C3%AE-induced-insufficient-autophagy-contributes-to-p62-dependent-apoptosis-of-epithelial-cells-in-chronic-rhinosinusitis-with-nasal-polyps
#19
Bao-Feng Wang, Ping-Ping Cao, Zhi-Chao Wang, Zhi-Yong Li, Zhe-Zheng Wang, Jin Ma, Bo Liao, Yi-Ke Deng, Xiao-Bo Long, Kai Xu, Heng Wang, Hai Wang, Ming Zeng, Xiang Lu, Zheng Liu
BACKGROUND: Autophagy is a lysosomal degradation pathway that is essential for cell survival, differentiation, and homeostasis. This study aimed to investigate the contribution of autophagy to the pathogenesis of CRS with nasal polyps (CRSwNP). METHODS: The expression of autophagic proteins [microtubule-associated protein 1 light chain 3B (LC3B)-II, autophagy-related proteins (Atg), and Beclin 1], substrate proteins (p62 and ubiquitinated proteins), and apoptotic signaling molecules [cysteine-aspartic protease-3 and 8, and poly-ADP-ribose polymerase] in the sinonasal mucosa and nasal epithelial cells (NECs) was detected by immunohistochemistry and Western blotting...
March 4, 2017: Allergy
https://www.readbyqxmd.com/read/28241864/ccl2-and-ccl5-driven-attraction-of-cd172a-monocytic-cells-during-an-equine-herpesvirus-type-1-ehv-1-infection-in-equine-nasal-mucosa-and-the-impact-of-two-migration-inhibitors-rosiglitazone-rsg-and-quinacrine-qc
#20
Jing Zhao, Katrien C K Poelaert, Jolien Van Cleemput, Hans J Nauwynck
Equine herpesvirus type 1 (EHV-1) causes respiratory disease, abortion and neurological disorders in horses. Besides epithelial cells, CD172a(+) monocytic cells become infected with EHV-1 in the respiratory mucosa and transport the virus from the apical side of the epithelium to the lamina propria en route to the lymph and blood circulation. Whether CD172a(+) monocytic cells are specifically recruited to the infection sites in order to pick up virus is unknown. In our study, equine nasal mucosa explants were inoculated with EHV-1 neurological strains 03P37 and 95P105 or the non-neurological strains 97P70 and 94P247 and the migration of monocytic cells was examined by immunofluorescence...
February 27, 2017: Veterinary Research
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