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https://www.readbyqxmd.com/read/29329807/nasal-adhesive-patches-approach-for-topical-application-for-dry-nasal-syndrome
#1
Flavia Laffleur
This present study intended to provide nasal adhesive formulations for the topical treatment of dry nasal syndrome. Mucoadhesive films were prepared according to solvent evaporation method consisting of well-known polymers such as gellan and carboxymethyl cellulose. Mucoadhesive films (A-E) were evaluated in respect to their physicochemical properties, stability, disintegration behavior and tensile strength. Moreover, uptake capacity of adhesive films was investigated according to three assays vapor uptake/ permeability and water uptake...
January 9, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29327590/a-simple-strategy-for-rapid-and-sensitive-detection-of-avian-influenza-a-h7n9-virus-based-on-intensity-modulated-spr-biosensor-and-new-generated-antibody
#2
Ying-Feng Chang, Wen-Hung Wang, Yi-Wei Hong, Ruei-Yu Yuan, Kuan-Hsuan Chen, Yu-Wen Huang, Po-Liang Lu, Yen-Hsu Chen, Yi-Ming Arthur Chen, Li-Chen Su, Sheng-Fan Wang
A new reassortant avian influenza A H7N9 virus have emerged in China since 2013, causing human infection with high mortality. An accurate and timely diagnosis is crucial for controlling the outbreaks of the disease. We therefore propose a simple strategy for rapidly and sensitively detecting the H7N9 virus using an intensity-modulated surface plasmon resonance (IM-SPR) biosensor integrated with a new generated monoclonal antibody. The novel antibody exhibits significant specificity to recognize H7N9 virus compared with other clinical human influenza isolates (p<0...
January 12, 2018: Analytical Chemistry
https://www.readbyqxmd.com/read/29318861/-clinical-trials-for-treatment-of-allergic-rhinitis-with-heat-sensitive-moxibustion-and-its-regularity-of-heat-sensitization-acupoint-distribution
#3
Yu-Fen Lin, Jian-Min Lu, Yan-Na Su, Ze-Bin Zhong, Zuo-Dan Zhang
OBJECTIVE: To observe the clinical effect of heat sensitive moxibustion (HSM) and its regularity of acupoint heat-sensitization in the treatment of allergic rhinitis (AR) patients. METHODS: Seventy patients with AR were randomly divided into HSM and manual acupuncture groups (n=35/group). For patients of the HSM group, acupoints Yintang (EX-HN 3), bilateral Yingxiang (LI 20), Shangxing (GV 23), Tongtian (BL 7), Feishu (BL 13), Hegu (LI 4), etc. were used, and for patients of the manual acupuncture group, bilateral LI 20 and LI 4, Bitong (EX-HN 8) and EX-HN 3 were needled and stimulated with uniform reinforcing-reducing needling method...
December 25, 2017: Zhen Ci Yan Jiu, Acupuncture Research
https://www.readbyqxmd.com/read/29317727/enhanced-nasal-drug-delivery-efficiency-by-increasing-mechanical-loading-using-hypergravity
#4
Dongjoo Kim, Young Hyo Kim, Soonjo Kwon
Nasal route drug administration for local and systemic delivery of many therapeutics has received attention because the nasal cavity is highly vascularized and provides a large surface area for drug absorption. However, nasal mucosa exhibits limited permeability to polar molecules. In this study, we developed a novel method for improving absorption efficiency of polar drugs by applying hypergravity. RPMI 2650 cells and primary human nasal epithelial cells were exposed three times to a 20 min hypergravitational condition (10 × g) with a 20 min rest period after each exposure...
January 9, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29311494/immunohistochemical-study-on-the-distribution-of-%C3%AE-defensin-1-and-%C3%AE-defensin-2-throughout-the-respiratory-tract-of-healthy-rats
#5
Natsumi Masuda, Youhei Mantani, Hideto Yuasa, Chiaki Yoshitomi, Masaya Arai, Miho Nishida, Wang-Mei Qi, Junichi Kawano, Toshifumi Yokoyama, Nobuhiko Hoshi, Hiroshi Kitagawa
The distributions of β-defensin 1 and 2 in secretory host defense system throughout respiratory tract of healthy rats were immunohistochemically investigated. In the nasal epithelium, a large number of non-ciliated and non-microvillous cells (NCs) were immunopositive for both β-defensin 1 and 2, whereas a small number of goblet cells (GCs) were immunopositive only for β-defensin 1. Beta-defensin 2-immunopositive GCs were few. In the nasal glands, a small number of acinar cells and a large number of ductal epithelial cells were immunopositive for both β-defensins...
January 1, 2018: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/29306235/expression-profiles-of-cd11b-galectin-1-beclin-1-and-caspase-3-in-nasal-polyposis
#6
Alper Dilci, Nuray Varol, İlker Kılıçcıoğlu, Ece Konac, Utku Aydil, Yusuf Kızıl, Sabri Uslu
Background/aim: Nasal polyposis is a chronic inflammatory disease affecting the paranasal sinuses and nasal mucosae. It is thought that genetic and molecular mechanisms in inflammatory and apoptotic pathways are the main factors in the etiopathogenesis of nasal polyposis. The aim of this study was to investigate the expression patterns of CD11b, galectin-1, beclin-1, and caspase-3 in nasal polyps.Materials and methods: The mRNA expression levels of CD11b, galectin-1, beclin-1, and caspase-3 protein and western blot analysis of caspase-3 protein were evaluated in inferior turbinate mucosae and nasal polyp tissues...
December 19, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/29299992/development-of-a-nasal-donepezil-loaded-microemulsion-for-treatment-of-alzheimer-s-disease-in-vitro-and-ex-vivo-characterization
#7
Lupe Carolina Espinoza, Marisol Vacacela, Beatriz Clares, Maria Luisa Garcia, Maria Jose Fabrega, Ana Cristina Calpena
BACKGROUND: Donepezil (DPZ) is widely prescribed as a specific and reversible acetylcholinesterase inhibitor for the symptomatic treatment of mild to moderate Alzheimer's disease (AD). OBJECTIVE: Considering the therapeutic potential of DPZ and the advantages offered by the intranasal route as an alternative for drug administration, the aim of this study was the development and characterization of a DPZ microemulsion (ME) for nose-to-brain delivery. METHOD: The ME was developed by construction of pseudoternary phase diagrams and characterized by dynamic light scattering and transmission electron microscopy...
January 4, 2018: CNS & Neurological Disorders Drug Targets
https://www.readbyqxmd.com/read/29290097/challenges-in-developing-mucosal-vaccine-and-antibodies-against-infectious-diarrhea-in-children
#8
REVIEW
Daisuke Tokuhara
Infectious diarrhea in children can be life-threatening and imposes a large economic burden on healthcare systems, therefore more effective prophylactic and therapeutic drugs are needed urgently. Because most of the pathogens responsible for childhood diarrhea infect the gastrointestinal mucosa, providing protective immunity at the mucosal surface is an ideal way to control pathogen invasion and toxic activity. Mucosal (e.g., oral, nasal) vaccines are superior to systemic (subcutaneous or intramuscular) vaccination for conferring both mucosal and systemic pathogen-specific immune responses...
December 31, 2017: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/29288502/type-iii-interferons-are-critical-host-factors-that-determine-susceptibility-to-influenza-a-viral-infection-in-allergic-nasal-mucosa
#9
Yung Jin Jeon, Jae Hyun Lim, Sujin An, Ara Jo, Doo Hee Han, Tae-Bin Won, Dong-Young Kim, Chae-Seo Rhee, Hyun Jik Kim
BACKGROUND: Allergic respiratory conditions have been associated with increased susceptibility to viral infection due to impaired interferon (IFN)-related immune responses but the mechanisms for reinforcement of mucosal immunity against viral infection in allergic diseases are largely unknown. OBJECTIVES: To determine whether IFN induction would be impaired in allergic nasal mucosa and to identify if higher loads of influenza A virus (IAV) in allergic nasal mucosa could be controlled with IFN treatment...
December 30, 2017: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29288039/immunoglobulin-g4-related-chronic-rhinosinusitis-a-pitfall-in-the-differential-diagnosis-of-granulomatosis-with-polyangiitis-rosai-dorfman-disease-and-fungal-rhinosinusitis
#10
Yingshi Piao, Yuan Zhang, Changli Yue, Chengshuo Wang, Luo Zhang
Immunoglobulin G4 (IgG4)-related chronic rhinosinusitis (CRS) has recently been proposed to be a new clinical entity of nasal disease, with no consensually agreed criteria for diagnosis. Moreover, the pathological features if IgG4-related CRS often overlap with other sinonasal inflammatory and autoimmune diseases such as Granulomatosis with Polyangiitis (GPA), Rosai-Dorfman disease (RDD) and Fungal Rhinosinusitis (FRS). We aimed to explore the specific similarities and differences in clinicopathologic features between IgG4-related CRS, and GPA, RDD and FRS, in order that these conditions can be diagnosed more accurately...
December 26, 2017: Human Pathology
https://www.readbyqxmd.com/read/29285053/establishment-of-a-mouse-model-of-lipopolysaccharide-induced-neutrophilic-nasal-polyps
#11
Shuibin Wang, Hanwu Zhang, Zulian Xi, Jingjing Huang, Jun Nie, Bin Zhou, Yuqin Deng, Zezhang Tao
Research has identified that gram-negative bacteria have an important role in refractory nasal polyps. In the present study, lipopolysaccharide (LPS) was used to establish a mouse model with neutrophilic nasal polyps in order to explore the effect and mechanism of LPS on the formation of neutrophilic nasal polyps in mice. A total of 5 or 10 µg of LPS was dropped into the nasal cavities of C57BL/6J mice in order to establish animal models with neutrophilic nasal polyps. Histological staining, toll-like receptor 4 (TLR4), cluster of differentiation 68 for macrophages and myeloperoxidase for neutrophil immunohistochemistry were used to observe histopathological changes in the nasal mucosa...
December 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29283946/rhinogenic-contact-point-headache-surgical-treatment-versus-medical-treatment
#12
Ignazio La Mantia, Calogero Grillo, Claudio Andaloro
Rhinogenic contact point headache (RCPH) is a headache syndrome secondary to mucosal contact points in the sinonasal cavities, in the absence of inflammatory signs, hyperplastic mucosa, purulent discharge, sinonasal polyps, or masses. It may result from pressure on the nasal mucosa due to anatomic variations among which the septal deviation, septal spur, and concha bullosa, are the most commonly observed. In recent years, RCPH has remained a subject of controversy regarding both its pathogenesis and treatment...
December 27, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29280870/components-of-the-hanging-columella-strategies-for-refinement
#13
Rod J Rohrich, Paul N Afrooz
The columella is a significant factor in the aesthetic balance of the nose, particularly the lower one-third of the nose. Its position is dependent on the anatomical constituents of the columella, and neighboring anatomical structures. Six components of the hanging columella have been identified: the caudal septum, medial crura, columellar skin, membranous septum, anterior nasal spine, and depressor septi nasi muscle. Columellar refinement begins with a careful analysis and diagnosis of the contributing components, followed by surgical techniques to address these components individually...
January 2018: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/29280492/unexpected-prominent-tension-pneumosella-five-years-after-endoscopic-endonasal-transsphenoidal-surgery
#14
Tatsuma Matsuda, Kentaro Horiguchi, Yoshinori Higuchi, Toyoyuki Hanazawa, Yoshitaka Okamoto, Yasuo Iwadate
Tension pneumosella (TP) is a rare entity reported as the invagination of the sphenoid sinus mucosa into the skull base after endonasal transsphenoidal surgery. Few studies have reported on TP, and in these studies, invagination is confined to either the intrasellar or suprasellar area. We encountered a case of unexpected prominent TP toward the intracranial space 5 years after endoscopic endonasal transsphenoidal surgery (EETS) for a nonfunctioning pituitary adenoma. In addition, we present a hypothesis of the underlying mechanism by a pressure gradient change between the extracranial and intracranial space in TP formation...
December 27, 2017: Laryngoscope
https://www.readbyqxmd.com/read/29278941/characteristics-of-lower-airway-inflammatory-changes-in-the-minimal-persistent-inflammation-of-allergic-rhinitis-in-mice
#15
Jie Xu, Li Gao, Hongbing Yao, Rong Zhang, Na Liu, Lijia Wang, Enmei Liu, Jihong Dai, Zhou Fu
OBJECTIVE: This study aims to establish an experimental mouse model of minimal persistent inflammation (MPI), observe the features of inflammation and hyper-responsiveness of the upper/lower airways, and explore the relationship between inflammation and hyper-responsiveness in the upper/lower airways. METHODS: Sixty-four female BALB/c mice were randomly divided into four groups: allergic rhinitis (AR) group as positive control, MPI group, negative control group and blank control group...
December 26, 2017: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/29277980/investigating-cross-contamination-by-yeast-strains-from-dental-solid-waste-to-waste-handling-workers-by-dna-sequencing
#16
Cristina Dutra Vieira, Thaysa Leite Tagliaferri, Maria Auxiliadora Roque de Carvalho, Maria Aparecida de Resende-Stoianoff, Rodrigo Assuncao Holanda, Thais Furtado Ferreira de Magalhães, Paula Prazeres Magalhães, Simone Gonçalves Dos Santos, Luiz de Macêdo Farias
Trying to widen the discussion on the risks associated with dental waste, this study proposed to investigate and genetically compare yeast isolates recovered from dental solid waste and waste workers. Three samples were collected from workers' hands, nasal mucosa, and professional clothing (days 0, 30, and 180), and two from dental waste (days 0 and 180). Slide culture, microscopy, antifungal drug susceptibility, intersimple sequence repeat analysis, and amplification and sequencing of internal transcribed spacer regions were performed...
December 26, 2017: MicrobiologyOpen
https://www.readbyqxmd.com/read/29274415/the-activation-and-function-of-il-36%C3%AE-in-neutrophilic-inflammation-in-chronic-rhinosinusitis
#17
Hai Wang, Zhi-Yong Li, Wen-Xiu Jiang, Bo Liao, Guan-Ting Zhai, Nan Wang, Zhen Zhen, Jian-Wen Ruan, Xiao-Bo Long, Heng Wang, Wei-Hong Liu, Geng-Tian Liang, Wei-Min Xu, Atsushi Kato, Zheng Liu
BACKGROUND: Although increased accumulation of neutrophils has been noted in chronic rhinosinusitis (CRS), the function and regulation of neutrophils in CRS are largely unknown. IL-36 family cytokines may play an important role in neutrophilic inflammation. OBJECTIVE: To investigate the expression and function of IL-36 cytokines in CRS. METHODS: Quantitative RT-PCR, immunohistochemistry, immunofluorescence, and ELISA were used to investigate the expression of IL-36 cytokines and IL-36 receptor (IL-36R) in sinonasal mucosa...
December 20, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29262451/-experimental-study-on-the-effect-of-yiqi-wenyang-decoction-on-nasal-mucosa-infiltration-of-nk-cells-in-mice-with-allergic-rhinitis
#18
X Q Chen, Q Ma, L Y Zhou, H A Ma, J Y Wu, J J Zhao, D N Yan
Objective: To observe the effect of Yiqi Wenyang Decoction on the infiltration and activation of NK cells in nasal mucosa of mouse model with allergic rhinitis (AR), and to explore the potential mechanism for effective intervention of AR with Yiqi Wenyang Decoction. Methods: Fourty-eight mice were randomly divided into blank group, model group, low, medium and high dose of Yiqi Wenyang Decoction group and Cetirizine group, with 8 rats in each group. After modeling of AR, the model group was filled with 0.9% sodium chloride solution...
December 7, 2017: Zhonghua Er Bi Yan Hou Tou Jing Wai Ke za Zhi, Chinese Journal of Otorhinolaryngology Head and Neck Surgery
https://www.readbyqxmd.com/read/29258402/pathology-of-the-emerging-mycobacterium-tuberculosis-complex-pathogen-mycobacterium-mungi-in-the-banded-mongoose-mungos-mungo
#19
Kathleen A Alexander, Peter N Laver, Mark C Williams, Claire E Sanderson, Carly Kanipe, Mitchell V Palmer
Wild banded mongooses ( Mungos mungo) in northeastern Botswana and northwest Zimbabwe are infected with a novel Mycobacterium tuberculosis complex (MTC) pathogen, Mycobacterium mungi. We evaluated gross and histologic lesions in 62 infected mongooses (1999-2017). Many tissues contained multifocal irregular, lymphohistiocytic to granulomatous infiltrates and/or multifocal or coalescing noncaseating to caseating granulomas with variable numbers of intralesional acid-fast bacilli. Over one-third of nasal turbinates examined had submucosal lymphohistiocytic to granulomatous infiltrates, erosion and ulceration of the nasal mucosa, bony remodeling, and nasal distortion...
January 1, 2017: Veterinary Pathology
https://www.readbyqxmd.com/read/29258267/cgamp-promotes-germinal-center-formation-and-production-of-iga-in-nasal-associated-lymphoid-tissue
#20
Hiromi Takaki, Ken Takashima, Hiroyuki Oshiumi, Akira Ainai, Tadaki Suzuki, Hideki Hasegawa, Misako Matsumoto, Tsukasa Seya
Induction of immunoglobulin (Ig) A in the mucosa of the upper respiratory tract and the nasal cavity protects against influenza virus infection. Cyclic dinucleotides (CDNs) are used as mucosal adjuvants to enhance the immunogenicity of intranasal influenza hemagglutinin (HA) vaccines. The adjuvant activity of 2'3' cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) on Ig production was investigated in nasal-associated lymphoid tissue (NALT), serum of wild-type C57BL/6J, and stimulator of interferon genes (STING)-deficient mice, which do not recognize cGAMP...
December 18, 2017: Medical Sciences: Open Access Journal
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