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https://www.readbyqxmd.com/read/29775717/temozolomide-loaded-nano-lipid-based-chitosan-hydrogel-for-nose-to-brain-delivery-characterization-nasal-absorption-histopathology-and-cell-line-study
#1
Anam Khan, Mohd Aqil, Syed Sarim Imam, Abdul Ahad, Yasmin Sultana, Asgar Ali, Khalid Khan
The present study was designed to develop and optimize Temozolomide nano lipid chitosan gel delivery (TMZNLCHG) to target the brain through nasal route. The formulation was developed using chitosan as a gelling agent and Vit E: gelucire 44/14 blend as lipid. The formulations were evaluated for particle size, drug loading, morphology, drug release, nasal diffusion, cell line study, and histopathology study. The average particle size, PDI, %EE, loading, drug release, and % permeation were found to be 134 nm, 0...
May 15, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29775027/-clinical-research-of-different-characteristics-of-fungal-ball-sinusitis
#2
M J Wang, B Zhou, Y C Li, S J Cui, Q Huang
Objective: The aim of this study is to investigate the clinical features of different subtypes of fungal ball sinusitis. Method: Four hundred and forty-nine cases with fungal ball rhinosinusitis (FBS) were involved in this retrospective analysis. The clinical features including symptoms, signs, and imaging scans, pathological results were all collected for each patient and the patients were classified into different subtypes according to these clinical features and the follow-up treatment. Result: In this retrospective study, 449 patients who diagnosed with fungal ball sinusitis were involved...
February 2018: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
https://www.readbyqxmd.com/read/29775013/-effects-of-highly-selective-branches-neurotomy-of-vidian-nerve-with-low-temperature-plasma-on-vasoactive-intestinal-peptide-in-nasal-mucosal-cells-of-patients-with-allergic-rhinitis
#3
P He, X J Jin, H Zhao
Objective: The aim of this study is to investigate the effect of highly selective branches neurotomy of vidian nerve with low temperature plasma on the level of vasoactive intestinal peptide in nasal mucosa of patients with allergic rhinitis. Method: Fifty patients with allergic rhinitis were selected as the experimental group. At the same time, 50 normal adults in our hospital were selected as the control group. Highly selective branches neurotomy of vidian nerve with low temperature plasma was performed to observe the changes of vascular intestinal peptide levels in patients with nasal mucosa and the clinical efficacy...
February 2018: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
https://www.readbyqxmd.com/read/29773884/pathologic-features-and-expression-of-heat-shock-protein-47-in-the-nasal-mucosa-and-lacrimal-sac-does-it-influence-the-surgical-outcome-of-endoscopic-endonasal-dacryocystorhinostomy
#4
Jinhwan Park, Joonsik Lee, Sehyun Baek
PURPOSE: To correlate the pathologic features and heat shock protein 47 (HSP47) expression in the nasal mucosa and lacrimal sac with the surgical outcomes of endoscopic endonasal dacryocystorhinostomy (EDCR). METHODS: Specimens of the nasal mucosa and lacrimal sac over the rhinostomy site were collected during the operation. Haematoxylin-eosin and immunohistochemical staining were performed to determine the pathologic features (inflammation, fibrosis, squamous metaplasia) and the expression of HSP47 in the epithelium and sub-epithelial glands of the nasal mucosa and lacrimal sac...
May 18, 2018: Eye
https://www.readbyqxmd.com/read/29772289/nose-to-brain-drug-delivery-an-update-on-clinical-challenges-and-progress-towards-approval-of-anti-alzheimer-drugs
#5
REVIEW
Mukta Agrawal, Swarnlata Saraf, Shailendra Saraf, Sophia G Antimisiaris, Mahavir Chougule, Sunday A Shoyele, Amit Alexander
According to the Alzheimer Association Report (2017), Alzheimer's disease (AD) is the 6th primary cause of death in the USA, which affects nearly 5.5 million people. In the year 2017 itself, the cost of AD treatment in the USA has been reported to rise to $259 billion. This statistic shows the severity of the disease in the USA which is very much similar across the globe. On the other hand, the treatment remains limited to a few conventional oral medications (approved by FDA). These are mainly acting superficially from mild to the moderate AD...
May 14, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29765272/approach-to-reconstruction-of-cheek-defects
#6
REVIEW
Berkay Başağaoğlu, Mohin Bhadkamkar, Pierce Hollier, Edward Reece
The cheek is the largest facial unit with a prominent position on the face. Trauma, burns, and the resection of skin cancers constitute common sources of injury, potentially resulting in defects that, through natural healing, produce noticeable scarring. Surgical repair focuses on the reformation of three-dimensional geometries, proper establishment of symmetry, and the minimization of color and texture discrepancies to the surrounding. Defects located in this region may extend to the orbital, nasal, or buccal units and cause unique structural and functional disturbances...
May 2018: Seminars in Plastic Surgery
https://www.readbyqxmd.com/read/29764011/efficacy-and-safety-of-autologous-stromal-vascular-fraction-in-the-treatment-of-empty-nose-syndrome
#7
Do-Youn Kim, Hye Ran Hong, Eun Wook Choi, Sang Won Yoon, Yong Ju Jang
Objectives: Regenerative treatment using stem cells may serve as treatment option for empty nose syndrome (ENS), which is caused by the lack of turbinate tissue and deranged nervous system in the nasal cavity. We aimed to assess the efficacy and safety of the autologous stromal vascular fraction (SVF) in the treatment of ENS. Methods: In this prospective observational clinical study, we enrolled 10 ENS patients who volunteered to undergo treatment of ENS through the injection of autologous SVF...
May 16, 2018: Clinical and Experimental Otorhinolaryngology
https://www.readbyqxmd.com/read/29762325/endoscopy-assisted-frontal-sinus-obliteration
#8
Anna Maria Jaźwiec, Benjamin Rechner, Ewa Komorowska-Timek
Comminuted fractures of the anterior table of the frontal sinus involving frontonasal ducts are traditionally treated with sinus obliteration. This technique entails precise mucosa removal which requires unimpeded visualization of the bony recesses. To achieve adequate access to the mucosa, temporary removal of a large part of the frontal bone may often be necessary. This in turn increases fracture comminution requiring placement of additional hardware associated with the risk for bony malalignment, infection, plate palpability, and visibility, especially in thin-skin individuals...
May 14, 2018: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29761612/acute-radiotherapy-toxicity-in-57-dogs-with-gross-and-microscopic-mast-cell-tumours
#9
L Blackwood, J B Tanis, A Harper, I Amores-Fuster, D R Killick, R Finotello
Mast cell tumours (MCTs) are commonly treated with radiation therapy, most often in a microscopic disease setting. Poorer outcomes are expected in patients with gross disease, and irradiation of gross disease may be associated with greater toxicity. The aim of this study was to compare acute radiation adverse events (AE) in dogs with gross and microscopic MCTs receiving radiotherapy. Fifty-seven dogs were included, 28 with gross disease and 29 with microscopic. In order to assess mucosal and skin toxicity, patients were assigned to 2 groups: head (29 patients, 14 patients with gross and 15 microscopic) and other sites (28 patients, 14 each)...
May 15, 2018: Veterinary and Comparative Oncology
https://www.readbyqxmd.com/read/29756518/the-route-by-which-intranasally-delivered-stem-cells-enter-the-central-nervous-system
#10
Carlos Galeano, Zhifang Qiu, Anuja Mishra, Steven L Farnsworth, Jacob J Hemmi, Alvaro Moreira, Peter Edenhoffer, Peter J Hornsby
Intranasal administration is a promising route of delivery of stem cells to the central nervous system (CNS). Reports on this mode of stem cell delivery have not yet focused on the route across the cribriform plate by which cells move from the nasal cavity into the CNS. In the current experiments, human mesenchymal stem cells (MSCs) were isolated from Wharton's jelly of umbilical cords and were labeled with extremely bright quantum dots (QDs) in order to track the cells efficiently. At 2 h after intranasal delivery in immunodeficient mice, the labeled cells were found under the olfactory epithelium, crossing the cribriform plate adjacent to the fila olfactoria, and associated with the meninges of the olfactory bulb...
January 1, 2018: Cell Transplantation
https://www.readbyqxmd.com/read/29755418/microbiome-and-culture-based-analysis-of-chronic-rhinosinusitis-compared-to-healthy-sinus-mucosa
#11
Kerstin Koeller, Daniel P R Herlemann, Tobias Schuldt, Attila Ovari, Ellen Guder, Andreas Podbielski, Bernd Kreikemeyer, Bernhard Olzowy
The role of bacteria in chronic rhinosinusitis (CRS) is still not well understood. Whole microbiome analysis adds new aspects to our current understanding that is mainly based on isolated bacteria. It is still unclear how the results of microbiome analysis and the classical culture based approaches interrelate. To address this, middle meatus swabs and tissue samples were obtained during sinus surgery in 5 patients with CRS with nasal polyps (CRSwNP), 5 patients with diffuse CRS without nasal polyps (CRSsNP), 5 patients with unilateral purulent maxillary CRS (upm CRS) and 3 patients with healthy sinus mucosa...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29753583/pyoderma-gangrenosum-on-the-nose
#12
Takuya Tomioka, Keiko Soma, Yoichiro Sato, Koshiro Miura, Ayako Endo
Pyoderma gangrenosum is a rare ulcerative condition associated with various systemic diseases. Lesions on the lower extremities and the trunk are common, but lesions on the nose are rare. Here we report a case of pyoderma gangrenosum on the nose. A 33-year-old woman presented with fever, nasal obstruction, and painful swelling on the nasal bridge. Physical examination revealed swellings on the nasal septal mucosa bilaterally. Computed tomography showed a septal abscess and a subcutaneous abscess on the nasal bridge...
May 9, 2018: Auris, Nasus, Larynx
https://www.readbyqxmd.com/read/29751365/the-interplay-between-risk-and-preventive-factors-explains-why-some-children-develop-allergies-to-certain-foods-and-others-show-tolerance
#13
REVIEW
Sami Remes, Petri Kulmala
AIM: A number of studies have clarified the tolerance mechanisms and risk factors for food allergies. Our aim was to explore food allergy symptoms by target organs, together with the risk factors and how to prevent food allergies and induce tolerance. METHODS: We carried out a thorough review of studies on paediatric food allergies published in the last decade. RESULTS: Food allergy symptoms may affect the skin, nasal and oral mucosa, conjunctivae, gastrointestinal tract, or, in severe cases, the respiratory tract and cardiovascular organs...
May 11, 2018: Acta Paediatrica
https://www.readbyqxmd.com/read/29747472/combining-mucilair%C3%A2-and-vitrocell-%C3%A2-powder-chamber-for-the-in-vitro-evaluation-of-nasal-ointments-in-the-context-of-aerosolized-pollen
#14
Julia Metz, Katharina Knoth, Henrik Groß, Claus-Michael Lehr, Carolin Stäbler, Udo Bock, Marius Hittinger
Hay fever is notoriously triggered when nasal mucosa is exposed to allergenic pollen. One possibility to overcome this pollen exposure may be the application of an ointment with physical protective effects. In this context, we have investigated Bepanthen® Eye and Nose Ointment and the ointment basis petrolatum as reference while using contemporary in vitro techniques. Pollen from false ragweed ( Iva xanthiifolia ) was used as an allergy-causing model deposited as aerosol using the Vitrocell® Powder Chamber (VPC) on Transwell® inserts, while being coated with either Bepanthen® Eye and Nose Ointment and petrolatum...
May 10, 2018: Pharmaceutics
https://www.readbyqxmd.com/read/29745623/the-role-of-intraoperative-stroke-volume-variation-on-bleeding-during-functional-endoscopic-sinus-surgery
#15
Roberta Di Mauro, Fabiana Lucci, Federica Martino, Maria B Silvi, Eleonora Gidaro, Santo Di Lorenzo, Nicola Toschi, Stefano Di Girolamo, Mario Dauri
BACKGROUNDː Functional Endoscopic Sinus Surgery (FESS) is a minimally-invasive surgical technique for patients with paranasal sinus pathology. Surgical bleeding reduces operative field visibility and increases the incidence of serious complications. Epinephrine injection into the nasal mucosa and controlled hypotension are used to minimise bleeding. Hypotension carries risks and sometimes does not reduce surgical bleeding. The goal of this study is to discover which haemodynamic parameter better correlates with surgical bleeding...
May 9, 2018: Minerva Anestesiologica
https://www.readbyqxmd.com/read/29742315/solitary-chemosensory-cells-producing-interleukin-25-and-group-2-innate-lymphoid-cells-are-enriched-in-chronic-rhinosinusitis-with-nasal-polyps
#16
Neil N Patel, Michael A Kohanski, Ivy W Maina, Vasiliki Triantafillou, Alan D Workman, Charles C L Tong, Edward C Kuan, John V Bosso, Nithin D Adappa, James N Palmer, De'Broski R Herbert, Noam A Cohen
BACKGROUND: Chronic rhinosinusitis with nasal polyps (CRSwNP) is commonly characterized by type-2 inflammation. It is established that group-2 innate lymphoid cells (ILC2s) are a subset of immune cells important in orchestrating mucosal type-2 response. IL-25 is an epithelial-derived cytokine that is a critical activator of ILC2s. Recent evidence demonstrates that specialized taster epithelial cells, such as solitary chemosensory cells (SCCs), may be producers of IL-25. To elucidate the relationship between SCCs and ILC2s in CRSwNP, we sought to quantify ILC2s and SCCs to determine if these cell types are enriched in nasal polyps compared to healthy sinonasal mucosa...
May 9, 2018: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/29741560/combined-nasal-osteotomies-with-caudal-transverse-osteotomy-and-their-effect-on-dorsal-geometry
#17
Ersoy Konas, Ozan Bitik
Background: Congenital, traumatic, or developmental bony vault deformities may require additional interventions rather than classical osteotomies to correct the surface structure or angulations of the nasal bones in rhinoplasty. Objectives: The aim of the study was to determine the effects of the additional osteotomies applied for the correction of the nasal vault asymmetries retrospectively. Methods: Twenty-one patients among 512 primary rhinoplasty cases between 2011-2016 with bony vault asymmetries were included into the study...
May 8, 2018: Aesthetic Surgery Journal
https://www.readbyqxmd.com/read/29738635/nasopharyngeal-versus-hypopharyngeal-packing-during-sino-nasal-surgeries-randomized-controlled-trial
#18
Mohamed G Alfiky, Osama A Margalani, Afnan F Rajeh, Fares E Alghamdi, Omar A Abu Suliman, Sumaiya H Muathen, Soha A Elmorsy
OBJECTIVES: Primary: to compare the severity of postoperative throat pain between patients who received a nasopharyngeal pack, and those who received a hypopharyngeal pack during their sino-nasal surgery. Secondary: to assess the efficacy of using a nasopharyngeal pack in preventing postoperative nausea and vomiting (PONV) and to compare its result with patients who received a hypopharyngeal pack. DESIGN: Prospective, randomized, controlled trial. SETTING: Tertiary Hospital...
May 8, 2018: Clinical Otolaryngology
https://www.readbyqxmd.com/read/29737365/-anaphylactic-reaction-to-camomile-tea
#19
S Wahl, P-G Sator
The case of a man with type I allergy after the intake of camomile tea is presented. About 30 min after consumption he was hospitalised with palmar pruritus, swelling of the eyelids, upper lip and nasal mucosa as well as narrowness of the throat. Hereditary angioedema was excluded. The skin prick test confirmed the diagnosis of a type I allergy due to camomile tea.
May 8, 2018: Der Hautarzt; Zeitschrift Für Dermatologie, Venerologie, und Verwandte Gebiete
https://www.readbyqxmd.com/read/29731101/pathogenic-and-protective-roles-of-b-cells-and-antibodies-in-patients-with-chronic-rhinosinusitis
#20
REVIEW
Bruce K Tan, Anju T Peters, Robert P Schleimer, Kathryn E Hulse
Chronic rhinosinusitis (CRS) is a chronic inflammatory disease of the nose and sinuses that affects up to 12% of the population in Europe and the United States. This complex disease is likely driven by multiple environmental, genetic, and inflammatory mechanisms, and recent studies suggest that B cells might play a critical role in disease pathogenesis. B cells and their antibodies have undisputed roles in health and disease within the airway mucosae. Deficient or inadequate B-cell responses can lead to susceptibility to infectious disease in the nose, whereas excess antibody production, including autoantibodies, can promote damaging inflammation...
May 2018: Journal of Allergy and Clinical Immunology
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