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https://www.readbyqxmd.com/read/28544688/prolonged-denervation-induces-remodeling-of-nasal-mucosa-in-rat-model-of-posterior-nasal-neurectomy
#1
Hironobu Nishijima, Kenji Kondo, Makiko Toma-Hirano, Shu Kikuta, Mizuo Ando, Rumi Ueha, Tatsuya Yamasoba
BACKGROUND: The posterior nasal nerve is the dominant source of the parasympathetic, sympathetic, and sensory fibers that innervate the nasal respiratory mucosa. Therefore, a posterior nasal neurectomy (PNN) induces denervation of the nasal mucosa and relieves the nasal symptoms of intractable rhinitis. PNN depletes nerve fibers, choline acetyltransferase, and neuropeptides in nasal respiratory mucosa, and reduces nasal secretion. However, the histological and symptomatic changes over an extended period after PNN remain unknown...
May 23, 2017: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/28542812/modulating-nasal-mucosal-permeation-using-metabolic-saturation-and-enzyme-inhibition-techniques
#2
Varsha Dhamankar, Maureen D Donovan
OBJECTIVE: Presystemic elimination resulting from local enzymatic degradation can play a key role in limiting the bioavailability of intranasally administered drugs. The aim of this study was to evaluate the transfer of a metabolically susceptible drug across the nasal mucosa to illustrate the relative contributions of drug diffusivity and metabolic susceptibility on overall nasal mucosal permeation and to understand the effects of changes in enzymatic activity on the transfer across nasal epithelial and submucosal tissues...
May 23, 2017: Journal of Pharmacy and Pharmacology
https://www.readbyqxmd.com/read/28541554/activation-of-group-2-innate-lymphoid-cells-exacerbates-and-confers-corticosteroid-resistance-to-mouse-nasal-type-2-inflammation
#3
Taiyo Morikawa, Ayumi Fukuoka, Kazufumi Matsushita, Koubun Yasuda, Naruhito Iwasaki, Shoko Akasaki, Shigeharu Fujieda, Tomohiro Yoshimoto
Both Th2 cells and group 2 innate lymphoid cells (ILC2s) contribute to allergic diseases. However, their exact role and relationship in nasal allergic disorders is unclear. In this study, we investigated the cooperation of Th2 cells and ILC2s in a mouse model of nasal allergic disorder. To differentially activate Th2 cells and/or ILC2s in nasal mucosa, mice were intranasally administered ovalbumin (OVA) antigen, papain, an ILC2-activator, or both for 2 weeks. Epithelial thickness and number of eosinophils in the nasal mucosa were evaluated at 24 hours after the final challenge...
May 25, 2017: International Immunology
https://www.readbyqxmd.com/read/28524814/genotoxic-and-cytotoxic-effects-in-exfoliated-buccal-and-nasal-cells-of-chromium-and-cobalt-exposed-electroplaters
#4
Georg Wultsch, Armen Nersesyan, Michael Kundi, Miroslav Mišík, Tahereh Setayesh, Monika Waldherr, Pavel Vodicka, Ludmila Vodickova, Siegfried Knasmüller
Results of a number of studies indicate that electroplaters have increased cancer risks as a consequence of exposure to genotoxic metals such as chromium (VI) and nickel. These effects may be due to induction of damage of the genetic material which plays a key role in the etiology of cancer, and it was found that workers in galvanization factories exhibited increased levels of DNA damage. The aim of the present study was to investigate genetic stability in workers of a bright plating factory who are exposed to chromium (Cr) and cobalt (Co)...
May 19, 2017: Journal of Toxicology and Environmental Health. Part A
https://www.readbyqxmd.com/read/28523041/functional-endoscopic-sinus-surgery-as-a-primary-modality-of-treatment-for-primary-and-recurrent-nasal-polyposis
#5
Mohammad Shahid Gohar, Saleem Asif Niazi, Sohail Baber Niazi
OBJECTIVES: To describe the efficacy of Functional Endoscopic Sinus Surgery(FESS) in our set up in comparison with other published studies to treat primary and recurrent nasal polyposis. METHOD: This descriptive study was conducted in 02 years at Ear Nose Throat Department Combined Military Hospital (CMH) Multan from October 2013 to October 2015. Convenient sample comprising 116 patients of both sexes of age group from 18 to 60 years were selected from ENT Out Patient Department, with documented diagnosis of nasal polyposis that underwent functional endoscopic sinus surgery...
March 2017: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/28521670/intranasal-drug-delivery-a-non-invasive-approach-for-the-better-delivery-of-neurotherapeutics
#6
Umesh Gupta, Hitesh Kumar, Gaurav Mishra, Ashok Kumar Sharma, Avinash Gothwal, Prashant Kesharwani
BACKGROUND: The convoluted pathophysiology of brain disorders along with penetration issue of drugs to brain represents major hurdle that requires some novel therapies. The blood-brain barrier (BBB) denotes a rigid barrier for delivery of therapeutics in vivo, to overcome this barrier intranasal delivery is an excellent strategy to deliver the drug directly to brain via olfactory and trigeminal nerve pathways that originate as olfactory neuro-epithelium in the nasal cavity and terminate in brain...
May 14, 2017: Pharmaceutical Nanotechnology
https://www.readbyqxmd.com/read/28504321/hemodynamic-responses-and-plasma-phenylephrine-concentrations-associated-with-intranasal-phenylephrine-in-children
#7
Lisa K Christensen, Valerie E Armstead, David P Bilyeu, Kenneth E Johnson, Robert H Friesen
INTRODUCTION: Intranasal phenylephrine, an alpha-1 adrenergic agonist, causes vasoconstriction of the nasal mucosa and is used to reduce bleeding associated with nasotracheal intubation or endoscopic sinus surgery. The purpose of this study was to describe the hemodynamic effects associated with plasma phenylephrine concentrations following topical intranasal administration of 0.25% and 0.5% phenylephrine in children. METHODS: After Institutional Review Board and parental approval, 77 children between the ages of 2 and 12 years were studied in a prospective, double-blind manner and randomized into three groups...
May 15, 2017: Paediatric Anaesthesia
https://www.readbyqxmd.com/read/28502093/the-tlr4-trif-pathway-can-protect-against-the-development-of-experimental-allergic-asthma
#8
Karim H Shalaby, Saba Al-Heialy, Kimitake Tsuchiya, Soroor Farahnak, Toby K McGovern, Paul-Andre Risse, Woong-Kyung Suh, Salman T Qureshi, James G Martin
The Toll-like Receptor (TLR) adaptor proteins Myeloid Differentiating Factor 88 (MyD88) and Toll, interleukin-1 Receptor and Resistance protein (TIR) domain-containing adaptor inducing interferon-β (TRIF) comprise the two principal limbs of the TLR signaling network. We studied the role of these adaptors in the TLR4-dependent inhibition of allergic airway disease and induction of CD4+ICOS+ T cells by nasal application of Protollin(™) , a mucosal adjuvant composed of TLR2 and 4 agonists. Wild-type (wt), Trif -/- or Myd88 -/- mice were sensitized to birch pollen extract (BPEx), then received intranasal Protollin followed by consecutive BPEx challenges...
May 14, 2017: Immunology
https://www.readbyqxmd.com/read/28498633/how-does-radioactive-iodine-affect-the-nose
#9
Ela Araz Server, Tolga Kirgezen, Ozlem Onerci Celebi, Muhammet Yildiz, Ozgur Yigit, Tevfik Fikret Cermik
OBJECTIVES/HYPOTHESIS: To determine the effect of radioactive iodine (RAI) treatment on the nasal mucosa and nasal functions. STUDY DESIGN: Prospective clinical study. METHODS: This study included 41 patients (31 female and 10 male) who were treated with RAI for papillary thyroid carcinoma. A visual analogue scale (VAS) was used for subjective evaluation of nasal symptoms. The saccharine test, nasal Schirmer test, and acoustic rhinometry were used for objective evaluation of nasal functions...
May 12, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28498078/kinetic-oscillatory-stimulation-of-nasal-mucosa-in-non-allergic-rhinitis-comparison-of-patient-self-administration-and-caregiver-administration-regarding-pain-and-treatment-effect-a-randomized-clinical-trial
#10
Alexander Juto, Anna Josefine Juto, Per von Hofsten, Finn Jörgensen
CONCLUSION: Patient self-administration of the Kinetic Oscillatory Stimulation (KOS)-catheter was a fully acceptable alternative to insertion of the catheter by physician with helmet fixation, in patients with non-allergic rhinitis (NAR). The approaches were equivalent regarding pain. The treatment effect in the patient self-administration group was not inferior. OBJECTIVES: To evaluate whether self-administration of a KOS-catheter was different compared to insertion by a physician, assessed with patient reported pain on a visual analogue scale (VAS)...
February 24, 2017: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/28497569/early-onset-of-efficacy-and-consistency-of-response-across-multiple-migraine-attacks-from-the-randomized-compass-study-avp-825-breath-powered-%C3%A2-exhalation-delivery-system-sumatriptan-nasal-powder-vs-oral-sumatriptan
#11
Stephen Silberstein, Paul K Winner, Peter J McAllister, Stewart J Tepper, Rashmi Halker, Ramy A Mahmoud, Joao Siffert
OBJECTIVE: To further characterize the clinical utility of AVP-825 based on additional prespecified outcomes and post hoc analyses of COMPASS, a Phase 3 comparative efficacy trial of AVP-825 vs 100 mg oral sumatriptan (NCT01667679). AVP-825 was approved in January 2016 by the US Food and Drug Administration under the name ONZETRA(®) Xsail(®) (sumatriptan nasal powder) for the acute treatment of migraine with or without aura in adults. BACKGROUND: AVP-825 is a delivery system that uses a patient's own breath to deliver low-dose sumatriptan powder to the upper posterior regions of the nasal cavity beyond the narrow nasal valve, areas lined with vascular mucosa conducive to rapid drug absorption into the systemic circulation...
May 11, 2017: Headache
https://www.readbyqxmd.com/read/28490406/closure-of-nasal-septal-perforations-with-a-polydioxanone-plate-and-temporoparietal-fascia-in-a-closed-approach
#12
Lorenz Epprecht, Christoph Schlegel, David Holzmann, Michael Soyka, Thomas Kaufmann
BACKGROUND: Septal perforation closure is still often invasive and complex, with relatively low closure rates. OBJECTIVES: We aimed to provide the first results of a case series of 20 patients with nasal septal perforations who underwent septal perforation repair by both an open and a minimally invasive technique by using a graft that consisted of temporoparietal fascia and a polydioxanone (PDS) plate without mucosal flaps. Between 2014 and 2016, we tested, for the first time, the feasibility of the insertion of this graft via a hemitransfixion incision at our institution...
May 1, 2017: American Journal of Rhinology & Allergy
https://www.readbyqxmd.com/read/28489243/nasal-pharyngeal-and-laryngeal-pemphigus-vulgaris-successfully-treated-with-rituximab
#13
Naveed Sami
Pemphigus vulgaris is a potentially fatal autoimmune blistering disease that can involve the nasopharyngeal and laryngeal tissues. The disease can be recalcitrant to conventional oral treatments, and treatment alternatives are limited. This retrospective study evaluated the efficacy of rituximab as a rescue agent in 5 patients with recalcitrant pemphigus vulgaris involving nasopharyngeal and laryngeal mucosa. All 5 patients were unresponsive to systemic steroids and at least one conventional oral immunosuppressive agent...
April 2017: Ear, Nose, & Throat Journal
https://www.readbyqxmd.com/read/28489239/therapeutic-effect-of-hyaluronic-acid-in-reducing-nasal-mucosa-recovery-time-after-septoplasty
#14
Francesco Klinger, Fabio Caviggioli, Andrea Vittorio Lisa, Luca Maione, Valeriano Vinci, Mattia Siliprandi, Federico Barbera, Marco Klinger, Luca Malvezzi
Mucociliary clearance represents a host defense mechanism of airways that can be compromised by various pathologic conditions, such as nasal septal deviation. Although septoplasty can resolve obstruction, it impairs mucociliary clearance in the immediate postoperative period. Clinical studies have demonstrated how hyaluronic acid can interfere with this function. Our study aims to provide evidence of a therapeutic effect of hyaluronic acid on nasal mucosa recovery after septoplasy. Sixty-five patients underwent septoplasty...
April 2017: Ear, Nose, & Throat Journal
https://www.readbyqxmd.com/read/28479048/digital-design-of-functional-surgery-for-odontogenic-cyst-intruding-into-maxillary-sinus
#15
Ying Kai Hu, Chi Yang, Guang Zhou Xu, Qian Yang Xie
INTRODUCTION: Traditional Caldwell-Luc approach needs modifications for odontogenic cysts intruding into the maxillary sinus, to preserve sinus mucosa and bony contour. Recently, digital technology has been widely applied to the field of maxillofacial surgery, guiding the surgical plan and improving its accuracy. OBJECTIVE: This study attempted to present and evaluate the functional surgery of odontogenic cysts intruding into the maxillary sinus using a computer-assisted pre-surgical design...
March 19, 2017: Brazilian Journal of Otorhinolaryngology
https://www.readbyqxmd.com/read/28477134/a-patient-specific-stem-cell-model-to-investigate-the-neurological-phenotype-observed-in-ataxia-telangiectasia
#16
Romal Stewart, Gautam Wali, Chris Perry, Martin F Lavin, Francois Féron, Alan Mackay-Sim, Ratneswary Sutharsan
The molecular pathogenesis of ataxia-telangiectasia (A-T) is not yet fully understood, and a versatile cellular model is required for in vitro studies. The occurrence of continuous neurogenesis and easy access make the multipotent adult stem cells from the olfactory mucosa within the nasal cavity a potential cellular model. We describe an efficient method to establish neuron-like cells from olfactory mucosa biopsies derived from A-T patients for the purpose of studying the cellular and molecular aspects of this debilitating disease...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28476614/a-strategy-for-bypassing-the-blood-brain-barrier-facial-intradermal-brain-targeted-delivery-via-the-trigeminal-nerve
#17
Xi-Chong Yu, Jing-Jing Yang, Bing-Hui Jin, He-Lin Xu, Hong-Yu Zhang, Jian Xiao, Cui-Tao Lu, Ying-Zheng Zhao, Wei Yang
Although intranasal delivery bypasses the blood-brain barrier (BBB), the anatomical location of the olfactory mucosa and respiratory airflow interference lead to less brain-targeted drug delivery. In addition to intranasal delivery, evidence indicates that facial intradermal injection might be a novel strategy for bypassing the BBB via the trigeminal nerve (TN). The hypothesis was verified by pharmacokinetic evaluation, nasal injury, lymphatic vessels inhibition and immunohistochemistry. Intradermal injection into the rat mystacial pad (i...
May 2, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28476105/case-of-disseminated-histoplasmosis-in-a-hiv-infected-patient-revealed-by-nasal-involvement-with-maxillary-osteolysis
#18
A C Lehur, M Zielinski, J Pluvy, V Grégoire, S Diamantis, A Bleibtreu, C Rioux, A Picard, D Vallois
BACKGROUND: Disseminated Histoplasmosis (DH) is a rare manifestation of Acquired Immune Deficiency Syndrome (AIDS) in European countries. Naso-maxillar osteolysis due to Histoplasma capsulatum var. capsulatum (Hcc) is unusual in endemic countries and has never been reported in European countries. Differential diagnoses such as malignant tumors, cocaine use, granulomatosis, vasculitis and infections are more frequently observed and could delay and/or bias the final diagnosis. CASE PRESENTATION: We report the case of an immunocompromised patient infected by Human Immunodeficiency Virus (HIV) with naso-maxillar histoplasmosis in a non-endemic country...
May 5, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28474799/non-allergic-rhinitis-position-paper-of-the-european-academy-of-allergology-and-clinical-immunology
#19
P W Hellings, L Klimek, C Cingi, I Agache, C Akdis, C Bachert, J Bousquet, P Demoly, P Gevaert, V Hox, C Hupin, L Kalogjera, F Manole, R Mösges, J Mullol, N B Muluk, A Muraro, N Papadopoulos, R Pawankar, C Rondon, M Rundenko, S F Seys, E Toskala, L Van Gerven, L Zhang, N Zhang, W J Fokkens
This EAACI position paper aims at providing a state-of-the-art overview on non-allergic rhinitis (NAR). A significant number of patients suffering from persistent rhinitis are defined as non-allergic non-infectious rhinitis (NANIR) patients, often denominated in short as having NAR. NAR is defined as a symptomatic inflammation of the nasal mucosa with the presence of minimal 2 nasal symptoms like nasal obstruction, rhinorrhoea, sneezing, and/or itchy nose, without clinical evidence of endonasal infection and without systemic signs of sensitization to inhalant allergens...
May 5, 2017: Allergy
https://www.readbyqxmd.com/read/28474294/influence-of-deviated-nasal-septum-on-nasal-epithelium-an-analysis
#20
Lakshit Kumar, Basavaraj P Belaldavar, Hema Bannur
Nasal obstruction is one of the most common complaint that ENT surgeon faces in his day to day practice. Deviated nasal septum is the most common cause for the nasal obstruction. It causes altered airflow dynamics which leads to various histopathological changes in nasal mucosa.Histopathological changes like lymphocytic infiltration and squamous metaplasia were studied and comparison was done between convex and concave side. A prospective randomized study conducted on 42 patients of deviated nasal septum from January 2015 to December 2015 selected from inpatient department of Otorhinolaryngology, KLES Dr...
May 4, 2017: Head and Neck Pathology
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