keyword
https://read.qxmd.com/read/38473258/survival-of-patients-with-sinonasal-cancers-in-a-population-based-registry-lombardy-italy-2008-2023
#21
JOURNAL ARTICLE
Dario Consonni, Simona Stella, Nerina Denaro, Alessandra Binazzi, Barbara Dallari, Sabrina Rugarli, Flavia Borello, Enzo Coviello, Carolina Mensi
Sinonasal cancers (SNCs) are rare malignancies associated with occupational exposures. The aim of this study was to analyse the survival of SNC patients using data from the population-based SNC registry of the Lombardy region (10 million people), Italy. We included epithelial SNC cases registered in 2008-2020 and followed-up for vital status until 31 July 2023. Multivariate flexible parametric models with time-dependent covariates were fitted to calculate excess hazard ratios (EHRs) and 95% confidence intervals (CIs) of death...
February 23, 2024: Cancers
https://read.qxmd.com/read/38470381/allergic-rhinitis-a-review
#22
JOURNAL ARTICLE
Jonathan A Bernstein, Joshua S Bernstein, Richika Makol, Stephanie Ward
IMPORTANCE: Allergic rhinitis affects an estimated 15% of the US population (approximately 50 million individuals) and is associated with the presence of asthma, eczema, chronic or recurrent sinusitis, cough, and both tension and migraine headaches. OBSERVATIONS: Allergic rhinitis occurs when disruption of the epithelial barrier allows allergens to penetrate the mucosal epithelium of nasal passages, inducing a T-helper type 2 inflammatory response and production of allergen-specific IgE...
March 12, 2024: JAMA
https://read.qxmd.com/read/38465788/dupilumab-prevents-nasal-epithelial-function-alteration-by-il-4-in-vitro-evidence-for-its-efficacy
#23
JOURNAL ARTICLE
Maxime Fieux, Florent Carsuzaa, Yvan Bellanger, Sophie Bartier, Virginie Fournier, Jean Claude Lecron, Matthieu Bainaud, Bruno Louis, Stéphane Tringali, Xavier Dufour, André Coste, Laure Favot, Emilie Bequignon
BACKGROUND: Chronic rhinosinusitis with nasal polyp (CRSwNP) is a typical type 2 inflammation involving interleukin (IL)-4 and IL-13. Dupilumab is a fully human monoclonal antibody targeting IL-4 receptor α subunit, thereby blocking signaling by both cytokines. Our hypothesis was that IL-4 and IL-13, by inducing a severe epithelial dysregulation, are involved in CRSwNP pathogenesis. This study aimed to evaluate the in vitro direct effect of IL-4, IL-13, and dupilumab on nasal epithelial functions...
March 11, 2024: International Forum of Allergy & Rhinology
https://read.qxmd.com/read/38455868/mir-224-5p-attenuates-allergic-responses-in-mice-with-allergic-rhinitis-by-modulating-the-th1-th2-response
#24
JOURNAL ARTICLE
Yuxiao Li, Ran An, Mingjin Wu, Jiayan He, Xiaoguang He
BACKGROUND: Allergic rhinitis (AR) is a common chronic respiratory disease that has become a global health problem. miRNAs play an important role in multiple immune and inflammatory diseases, including AR. In this work, the mechanism by which miR-224-5p regulates AR in vivo and in vitro was examined. METHODS: Human nasal epithelial cells (HNEpCs) were used to establish an AR cell model induced by Der P1, and C57BL/6 mice were used to establish an AR animal model induced by OVA (ovalbumin)...
2024: Analytical Cellular Pathology (Amsterdam)
https://read.qxmd.com/read/38444858/increased-glycolysis-and-cellular-crosstalk-in-eosinophilic-chronic-rhinosinusitis-with-nasal-polyps
#25
JOURNAL ARTICLE
George X Huang, Michael V Mandanas, Sarah Djeddi, Daniela Fernandez-Salinas, Maria Gutierrez-Arcelus, Nora A Barrett
INTRODUCTION: Chronic rhinosinusitis (CRS) is a chronic inflammatory disease of the sinonasal mucosa with distinct endotypes including type 2 (T2) high eosinophilic CRS with nasal polyps (eCRSwNP), T2 low non-eosinophilic CRS with nasal polyps (neCRSwNP), and CRS without nasal polyps (CRSsNP). METHODS: Given the heterogeneity of disease, we hypothesized that assessment of single cell RNA sequencing (scRNA-seq) across this spectrum of disease would reveal connections between infiltrating and activated immune cells and the epithelial and stromal populations that reside in sinonasal tissue...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38442581/cd109-identified-in-circulating-proteomics-mitigates-postoperative-recurrence-in-chronic-rhinosinusitis-with-nasal-polyps-by-suppressing-tgf-%C3%AE-1-induced-epithelial-mesenchymal-transition
#26
JOURNAL ARTICLE
Ru Gao, Yu Chen, Huihong Liu, Maoyu Ye, Ling Chu, Tiansheng Wang
BACKGROUND: Chronic rhinosinusitis with nasal polyps (CRSwNP) is a common inflammatory disorder with a high rate of recurrence. This study aimed to explore biomarkers for identifying patients with recurrent CRSwNP (rCRSwNP). METHODS: We recruited two independent cohorts. In the discovery cohort, rCRSwNP patients and non-recurrent CRSwNP (non-rCRSwNP) patients were recruited, and the serum proteomic profile was characterized. The top 5 upregulated and downregulated proteins were confirmed in the validation cohort by ELISA, WB, and qRT-PCR, and their predictive values for postoperative recurrence were assessed...
March 4, 2024: International Immunopharmacology
https://read.qxmd.com/read/38440623/sinonasal-hamartoma-and-chronic-laryngeal-edema-causing-severe-dyspnea
#27
JOURNAL ARTICLE
Jelena Gavric, Svetlana Valjarevic, Milan B Jovanovic, Nenad Miladinovic
BACKGROUND: Sinonasal hamartomas, according to the 5th edition of the World Health Organisation classification of head and neck tumours are divided into respiratory epithelial adenomatoid hamartoma (REAH), seromucinous hamartoma and chondromesenchymal hamartoma. Seromucinous hamartoma are benign proliferations of small eosinophilic glands surrounded by fibrous stroma and cuboidal cells. Hamartomas of the nasal cavity and paranasal sinuses are rare entities, clinically presenting as sinonasal polyposis...
February 2024: Indian Journal of Otolaryngology and Head and Neck Surgery
https://read.qxmd.com/read/38433216/platycodon-d-protects-human-nasal-epithelial-cells-from-pyroptosis-through-the-nrf2-ho-1-ros-signaling-cascade-in-chronic-rhinosinusitis
#28
JOURNAL ARTICLE
Ruizhi Wang, Yongchun Wang, He Liu, Jinxiang Zhu, Caishan Fang, Weizhen Xu, Zesheng Lu, Yajie Yan, Weiping He, Yan Ruan, Min Zhou
BACKGROUND: Pyroptosis has been demonstrated being closely associated with the inflammatory progression in chronic rhinosinusitis (CRS). However, platycodon D (PLD) has emerged as a key anti-inflammatory mediator in the inflammatory progression of various respiratory diseases. This study aims at investigating whether PLD could reduce inflammatory progression of CRS by inhibiting pyroptosis. METHODS: Nasal mucosal tissues from patients with CRS and the control group (simple nasal septal deviation) were analyzed for morphological difference using hematoxylin & eosin staining and for the expression of pyroptosis-related makers by immunofluorescence (IF)...
March 4, 2024: Chinese Medicine
https://read.qxmd.com/read/38427106/comprehensive-analysis-of-dna-methylation-gene-expression-profiles-in-geo-dataset-reveals-biomarkers-related-to-malignant-transformation-of-sinonasal-inverted-papilloma
#29
JOURNAL ARTICLE
Li Mu, Shun Hu, Guoping Li, Ping Wu, Ke Zheng, Sheng Zhang
BACKGROUND: DNA methylation may be involved in the regulation of malignant transformation from sinonasal inverted papilloma (SNIP) to squamous cell carcinoma (SCC). The study of gene methylation changes and screening of differentially methylated loci (DMLs) are helpful to predict the possible key genes in the malignant transformation of SNIP-SCC. MATERIALS AND METHODS: Microarray dataset GSE125399 was downloaded from the Gene Expression Omnibus (GEO) database and differentially methylated loci (DMLs) were analyzed using R language (Limma package)...
March 1, 2024: Discover. Oncology
https://read.qxmd.com/read/38426234/eosinophil-extracellular-traps-in-eosinophilic-chronic-rhinosinusitis-induce-charcot-leyden-crystal-formation-and-eosinophil-recruitment
#30
JOURNAL ARTICLE
Siyuan Zhang, Zhenlin Wang
Eosinophil extracellular traps (EETs) are implicated in various eosinophil-associated diseases; however, their role in chronic rhinosinusitis (CRS) remains unclear. In the present study, 57 CRS patients were enrolled, and immunofluorescence was used to analyze EETs in eosinophilic (eCRS) and non-eosinophilic (Non-eCRS) tissues. MSD was used to examine IL-4, IL-5, and IL-13 concentrations in tissue homogenates. Charcot-Leyden crystals (CLCs) protein expression was detected in PMA, PMA+DNase I, and blank control eosinophils using ELISA...
March 29, 2024: Bioscience Reports
https://read.qxmd.com/read/38422887/silencing-of-forkhead-box-c1-reduces-nasal-epithelial-barrier-damage-in-mice-with-allergic-rhinitis-via-epigenetically-upregulating-secreted-frizzled-related-protein-5
#31
JOURNAL ARTICLE
Zhaohui Shi, Tianfeng Zhao, Dingbo Li, Chong Wang, Yanjie Luo, Yangshan Zheng
Allergic rhinitis (AR) is caused by immunoglobulin E (IgE)-mediated reactions to inhaled allergens, which leads to mucosal inflammation and barrier dysfunction. The transcription factor forkhead box C1 (FOXC1) has been identified to be associated with allergic inflammation. This study sought to uncover the role of FOXC1 in AR. A murine model of AR was induced by repeated intranasal ovalbumin (OVA) challenges. Results revealed that high FOXC1 expression was found in the nasal mucosal epithelium of AR mice. Nasal allergy symptoms, mucosal epithelial swelling, goblet cell hyperplasia and eosinophil infiltration in AR mice were attenuated after silencing of FOXC1...
February 28, 2024: Molecular Immunology
https://read.qxmd.com/read/38419131/pragmatic-return-to-effective-dental-infection-control-through-triage-and-testing-predict-an-observational-feasibility-study-to-improve-dental-office-safety
#32
JOURNAL ARTICLE
Janine Fredericks-Younger, Cecile A Feldman, Veerasathpurush Allareddy, Ellen Funkhouser, MaryAnn McBurnie, Cyril Meyerowitz, Pat Ragusa, Julie Chapman-Greene, Modupe Coker, Daniel Fine, Maria Laura Gennaro, Gayathri Subramanian
BACKGROUND: During the COVID-19 pandemic, there was a substantial interruption of care, with patients and workers fearful to return to the dental office. As dental practice creates a highly aerosolized environment, the potential for spread of airborne illness is magnified. As a means to increase safety and mitigate risk, pre-visit testing for SARS-CoV-2 has the potential to minimize disease transmission in dental offices. The Pragmatic Return to Effective Dental Infection Control through Testing (PREDICT) Feasibility Study examined the logistics and impact of two different testing mechanisms (laboratory-based PCR viral testing and point-of-care antigen testing) in dental offices...
February 28, 2024: Pilot and Feasibility Studies
https://read.qxmd.com/read/38419061/p80-natural-essence-spray-and-lozenges-provide-respiratory-protection-against-influenza-a-b-and-sars-cov-2
#33
JOURNAL ARTICLE
Viktoria Zaderer, Gabriel Diem, Wilfried Posch, Thomas Jakschitz, Günther K Bonn, Rosa Bellmann-Weiler, Lukas A Huber, Doris Wilflingseder
Seasonally circulating viruses, such as Influenza, as well as newly emerging viruses and variants thereof, and waning immunity urge the need for safe, easy-to-use and inexpensive drugs to protect from these challenges. To prevent transmission of these viruses and subsequent excessive inflammatory reactions on mucous membranes, we tested the efficacy of the natural essence P80 as spray and in form of lozenges against respiratory infections caused by SARS-CoV-2 variants of concern (VoCs), influenza A (H3N2) and influenza B (Victoria)...
February 28, 2024: Respiratory Research
https://read.qxmd.com/read/38414109/radiographic-and-computed-tomographic-characteristics-of-intraluminal-tracheal-adenoma-in-a-cat
#34
JOURNAL ARTICLE
Yoojin An, Yeonhee Lee, Sungsoo Kim, Kichang Lee, Hakyoung Yoon
A 13-year-old spayed female Persian cat presented with dyspnea and nasal discharge. Thoracic radiography revealed a dome-shaped soft-tissue opacity in the carina. Computed tomography confirmed a soft tissue-attenuating mass in the carina and the left and right proximal main bronchi that appeared to arise from the tracheal wall. Tracheoscopy revealed an intraluminal broad-based mass with multilobulated borders at the same location. Histopathological evaluation revealed a benign neoplastic process of the glandular epithelial lineage, which was considered an adenoma...
February 27, 2024: Veterinary Radiology & Ultrasound
https://read.qxmd.com/read/38413298/splunc1-as-a-biomarker-of-pulmonary-exacerbations-in-children-with-cystic-fibrosis
#35
JOURNAL ARTICLE
E Ben-Meir, L Perrem, M Shaw, F Ratjen, H Grasemann
BACKGROUND: Short palate, lung, and nasal epithelium clone 1 (SPLUNC1) is an innate defence protein that acts as an anti-microbial agent and regulates airway surface liquid volume through inhibition of the epithelial sodium channel (ENaC). SPLUNC1 levels were found to be reduced in airway secretions of adults with cystic fibrosis (CF). The potential of SPLUNC1 as a biomarker in children with CF is unknown. METHODS: We quantified SPLUNC1, interleukin-8 (IL-8) and neutrophil elastase (NE) in sputum of CF children treated with either intravenous antibiotics or oral antibiotics for a pulmonary exacerbation (PEx)s, and in participants of a prospective cohort of CF children with preserved lung function on spirometry, followed over a period of two years...
February 26, 2024: Journal of Cystic Fibrosis: Official Journal of the European Cystic Fibrosis Society
https://read.qxmd.com/read/38410446/cd4-and-cd8-t-cells-are-required-to-prevent-sars-cov-2-persistence-in-the-nasal-compartment
#36
Meenakshi Kar, Katherine E E Johnson, Abigail Vanderheiden, Elizabeth J Elrod, Katharine Floyd, Elizabeth Geerling, E Taylor Stone, Eduardo Salinas, Stephanie Banakis, Wei Wang, Shruti Sathish, Swathi Shrihari, Meredith E Davis-Gardner, Jacob Kohlmeier, Amelia Pinto, Robyn Klein, Arash Grakoui, Elodie Ghedin, Mehul S Suthar
SARS-CoV-2 is the causative agent of COVID-19 and continues to pose a significant public health threat throughout the world. Following SARS-CoV-2 infection, virus-specific CD4+ and CD8+ T cells are rapidly generated to form effector and memory cells and persist in the blood for several months. However, the contribution of T cells in controlling SARS-CoV-2 infection within the respiratory tract are not well understood. Using C57BL/6 mice infected with a naturally occurring SARS-CoV-2 variant (B.1.351), we evaluated the role of T cells in the upper and lower respiratory tract...
January 24, 2024: bioRxiv
https://read.qxmd.com/read/38399972/feasibility-study-of-developing-a-saline-based-antiviral-nanoformulation-containing-lipid-soluble-egcg-a-potential-nasal-drug-to-treat-long-covid
#37
JOURNAL ARTICLE
Nicolette Frank, Douglas Dickinson, William Garcia, Yutao Liu, Hongfang Yu, Jingwen Cai, Sahaj Patel, Bo Yao, Xiaocui Jiang, Stephen Hsu
UNLABELLED: A recent estimate indicates that up to 23.7 million Americans suffer from long COVID, and approximately one million workers may be out of the workforce each day due to associated symptoms, leading to a USD 50 billion annual loss of salary. Post-COVID (Long COVID) neurologic symptoms are due to the initial robust replication of SARS-CoV-2 in the nasal neuroepithelial cells, leading to inflammation of the olfactory epithelium (OE) and the central nervous system (CNS), and the OE becoming a persistent infection site...
January 27, 2024: Viruses
https://read.qxmd.com/read/38398010/a-novel-bionebulizer-approach-to-study-the-effects-of-natural-mineral-water-on-a-3d-in-vitro-nasal-model-from-allergic-rhinitis-patients
#38
JOURNAL ARTICLE
Joana Viegas, Elsa M Cardoso, Lucile Bonneau, Ana Filipa Esteves, Catarina L Ferreira, Gilberto Alves, António Jorge Santos-Silva, Marco Vitale, Fernando A Arosa, Luís Taborda-Barata
Sulfurous thermal waters (STWs) are used as a complementary treatment for allergic rhinitis. However, there is scant data on the effects of STW on nasal epithelial cells, and in vitro models are warranted. The main aim of this study was to evaluate the dose and time effects of exposure to 3D nasal inserts (MucilAirTM -HF allergic rhinitis model) with STW or isotonic sodium chloride solution (ISCS) aerosols. Transepithelial electrical resistance (TEER) and histology were assessed before and after nebulizations...
February 9, 2024: Biomedicines
https://read.qxmd.com/read/38397788/redox-imbalance-in-nasal-epithelial-cells-of-primary-ciliary-dyskinesia-patients
#39
JOURNAL ARTICLE
Ana Reula, Silvia Castillo-Corullón, Miguel Armengot, Guadalupe Herrera, Amparo Escribano, Francisco Dasí
Background: Primary Ciliary Dyskinesia (PCD) represents a rare condition marked by an abnormal mobility pattern of cilia and flagella, resulting in impaired mucociliary clearance. This deficiency leads to recurrent infections and persistent inflammation of the airways. While previous studies have indicated heightened oxidative stress levels in the exhaled breath condensate of pediatric PCD patients, the assessment of oxidative stress within the affected respiratory tissue remains unexplored. Aims: To assess the oxidative status of human nasal epithelial cells (NECs) in PCD patients...
February 2, 2024: Antioxidants (Basel, Switzerland)
https://read.qxmd.com/read/38397588/-chaenomeles-sinensis-extract-ameliorates-ovalbumin-induced-allergic-rhinitis-by-inhibiting-the-il-33-st2-axis-and-regulating-epithelial-cell-dysfunction
#40
JOURNAL ARTICLE
Juan Jin, Yan Jing Fan, Thi Van Nguyen, Zhen Nan Yu, Chang Ho Song, So-Young Lee, Hee Soon Shin, Ok Hee Chai
Chaenomeles sinensis has traditionally been used as an herbal medicine due to its characteristics that protect against inflammation, hypertension, and mutagenesis. However, the effect of Chaenomeles sinensis extract (CSE) on allergic rhinitis (AR) and its underlying mechanisms have yet to be thoroughly investigated. The current study explored the likely effect of CSE on AR in an ovalbumin (OVA)-induced AR mouse model. To this end, OVA-specific immunoglobulins, nasal symptoms, cytokine production, the infiltration of inflammatory cells, and nasal histopathology were assessed to determine the role of CSE against AR...
February 18, 2024: Foods (Basel, Switzerland)
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