Meenakshi Kar, Katherine E E Johnson, Abigail Vanderheiden, Elizabeth J Elrod, Katharine Floyd, Elizabeth Geerling, E Taylor Stone, Eduardo Salinas, Stephanie Banakis, Wei Wang, Shruti Sathish, Swathi Shrihari, Meredith E Davis-Gardner, Jacob Kohlmeier, Amelia Pinto, Robyn Klein, Arash Grakoui, Elodie Ghedin, Mehul S Suthar
SARS-CoV-2 is the causative agent of COVID-19 and continues to pose a significant public health threat throughout the world. Following SARS-CoV-2 infection, virus-specific CD4+ and CD8+ T cells are rapidly generated to form effector and memory cells and persist in the blood for several months. However, the contribution of T cells in controlling SARS-CoV-2 infection within the respiratory tract are not well understood. Using C57BL/6 mice infected with a naturally occurring SARS-CoV-2 variant (B.1.351), we evaluated the role of T cells in the upper and lower respiratory tract...
January 24, 2024: bioRxiv