keyword
MENU ▼
Read by QxMD icon Read
search

nasal epithelial

keyword
https://www.readbyqxmd.com/read/27908567/the-effect-of-topical-5-flurouracil-application-post-endoscopic-inferior-turbinoplasty
#1
Amjad F Nuseir, Mohammad Alsalem, Mouhamad Alzahr, Muthanna Ababneh, Ahmad I Alomari, Firas Alzoubi
RATIONALE AND OBJECTIVES: Adhesions are the most common complication after nasal surgery and revision. 5-Fluorouracil (5-FU) reduces various adhesions and epithelial growth related complications. The aim of this study was to evaluate the effects of 5-flurouracil application in the nasal cavity after a multi-procedure nasal surgery in term of complications frequency. MATERIALS AND METHODOLOGY: Institutional ethical approval was granted and a double-blinded prospective clinical trial was conducted to study the effect of 5-fu on post-operative complications...
November 23, 2016: American Journal of Otolaryngology
https://www.readbyqxmd.com/read/27906054/is-radical-surgery-of-an-inverted-papilloma-of-the-maxillary-sinus-obsolete-a-case-report
#2
Vedat Yildirim, Niels Christian Pausch, Dirk Halama, Heinz-Theo Lübbers, Ayhan Yildirim
BACKGROUND: Sinonasal inverted papilloma is a locally aggressive tumor arising from the Schneiderian membrane which lines the nasal cavity and paranasal sinuses. Aggressive surgical approaches, such as lateral rhinotomy, were used until recently for complete removal of the inverted papilloma. Currently, endoscopic resection is the gold standard in the treatment of inverted papilloma. However, there are situations that justify an open approach. For example there are studies that report a higher postoperative recurrence rate after endonasal endoscopic resection, particularly in the treatment of recurrent diseases...
December 1, 2016: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/27902722/canonical-wnt-signaling-drives-tumor-like-lesions-from-sox2-positive-precursors-of-the-murine-olfactory-epithelium
#3
Nils W Engel, Julia E Neumann, Julia Ahlfeld, Annika K Wefers, Daniel J Merk, Jasmin Ohli, Ulrich Schüller
Canonical Wnt signaling is known to promote proliferation of olfactory stem cells. In order to investigate the effects of a constitutive activation of Wnt signaling in Sox2-positive precursor cells of the olfactory epithelium, we used transgenic mice that allowed an inducible deletion of exon 3 of the Ctnnb1 gene, which is responsible for the phosphorylation and degradation of Ctnnb1 protein. After induction of aberrant Wnt activation by Ctnnb1 deletion at embryonic day 14, such mice developed tumor-like lesions in upper parts of the nasal cavity...
2016: PloS One
https://www.readbyqxmd.com/read/27897275/an-ex-vivo-model-contributing-to-the-diagnosis-and-evaluation-of-new-drugs-in-cystic-fibrosis
#4
A M Di Lullo, M Scorza, F Amato, M Comegna, V Raia, L Maiuri, G Ilardi, E Cantone, G Castaldo, M Iengo
Cystic fibrosis (CF) is an autosomal recessive disease caused by mutations in the cystic fibrosis transmembrane regulator (CFTR) gene. About 2000 mutations have been described so far. We setup an ex vivo model of human nasal epithelial cells (HNECs) to study CF patients testing the effect of novel mutations and molecular therapies. We performed the sampling (by brushing), followed by culture and analysis of HNECs using a series of molecular techniques. We performed 50 brushings from CF patients and controls...
November 29, 2016: Acta Otorhinolaryngologica Italica
https://www.readbyqxmd.com/read/27894610/-reconstruction-of-proximal-nasal-defect-after-deep-carcinological-resection-interest-to-combine-titane-mesh-with-fat-grafting
#5
R Aimard, C Lalloué, C Ho Quoc, D Girodet, P Zrounba, E Delay
INTRODUCTION: The mucosal cylindroma or adenoid cystic carcinoma is the second sinonasal non-epithelial malignant tumor frequency argument. Due to the achievement of the nasal mucosa and a late diagnosis reconstructions are often complex. We report the case of a mucous cylindroma recurrence of nasal septum requiring a wide and deep excision of the root of the nose with nasal reconstruction. CASE REPORT: A patient aged 66 years whose history resection two years ago with a mucous adenoid cystic carcinoma of the right side of the nasal septum, had a local recurrence T2NOM0 imposing a wide excision with amputation nasal septum own bones of nose, the anterior portion of the triangular cartilages...
November 25, 2016: Annales de Chirurgie Plastique et Esthétique
https://www.readbyqxmd.com/read/27890621/nasal-drug-delivery-design-of-a-novel-mucoadhesive-and-in-situ-gelling-polymer
#6
Claudia Menzel, Max Jelkmann, Flavia Laffleur, Andreas Bernkop-Schnürch
The aim of the present study was to establish a novel polymeric excipient for liquid nasal dosage forms exhibiting viscosity increasing properties, improved mucoadhesion and stability towards oxidation in solution. In order to achieve this goal, 2-mercaptonicotinic acid was first coupled to L-cysteine by disulfide exchange reaction and after purification directly attached to the polymeric backbone of xanthan gum by carbodiimide mediated amide bond formation. The resulting conjugate was characterized with respect to the amount of coupled ligand, the in situ gelling behavior, mucoadhesive properties and stability towards oxidation...
November 24, 2016: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/27888644/myrtol-standardized-affects-mucociliary-clearance
#7
Ying Ying Li, Jing Liu, Chun Wei Li, Somasundaram Subramaniam, Siew Shuen Chao, Feng Gang Yu, Noam A Cohen, Shi Li, Yun Wang
BACKGROUND: Myrtol standardized (Gelomyrtol forte) has been shown to be effective in controlling nasal symptoms of rhinosinusitis by promoting mucociliary clearance. Our aim was to evaluate the short- and long-term effects of myrtol on ciliated columnar cells and goblet cells in an in-vitro setting. METHODS: Nasal epithelial cells were harvested (42 days) from an air-liquid interface (ALI) culture of human nasal epithelial stem/progenitor cells (hNESPCs), which was derived from biopsies of nasal inferior turbinate mucosa...
November 26, 2016: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/27885166/the-role-of-interleukin-33-in-chronic-rhinosinusitis
#8
Dong-Kyu Kim, Hong Ryul Jin, Kyoung Mi Eun, Ji-Hun Mo, Seong H Cho, Sohee Oh, David Cho, Dae Woo Kim
RATIONALE: Interleukin (IL)-33, a new member of the IL-1 family, is constitutively expressed in epithelial tissues and lymphoid organs and plays an important role in the pathogenesis of allergic disease. However, the role of IL-33 in chronic rhinosinusitis with nasal polyps (CRSwNP) remains unclear. OBJECTIVE: To investigate the role of IL-33 in the pathophysiology of CRSwNP. METHODS: We investigated IL-33 expression and its cellular origins in the nasal polyps (NPs) of human subjects by immunohistochemistry (IHC), quantitative reverse transcription PCR (qRT-PCR), and multiplex cytokine assays...
November 24, 2016: Thorax
https://www.readbyqxmd.com/read/27878968/proprotein-convertase-inhibition-promotes-ciliated-cell-differentiation-a-potential-mechanism-for-the-inhibition-of-notch1-signalling-by-decanoyl-rvkr-chloromethylketone
#9
Sang-Nam Lee, In-Suk Choi, Hyun Jun Kim, Eun Jin Yang, Hyun Jin Min, Joo-Heon Yoon
Chronic repetitive rounds of injury and repair in the airway lead to airway remodelling, including ciliated cell loss and mucous cell hyperplasia. Airway remodelling is mediated by many growth and differentiation factors including Notch1, which are proteolytically processed by proprotein convertases (PCs). The present study evaluated a novel approach for controlling basal cell-type determination based on the inhibition of PCs. It was found that decanoyl-RVKR-chloromethylketone (CMK), a PC inhibitor, promotes ciliated cell differentiation and has no effect on the ciliary beat frequency in air-liquid interface (ALI) cultures of human nasal epithelial cells (HNECs)...
November 22, 2016: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/27876739/-the-state-of-the-nasal-mucosa-and-the-paranasal-sinuses-in-the-late-postoperative-period-following-radical-and-minimally-invasive-surgery
#10
M M Magomedov, D F Zeinalova, D V Andriyashkin, N M Magomedova, A E Starostina, M V Zvereva
We have investigated the functional state of the mucous membrane of the nasal cavity and maxillary sinus after radical and minimally invasive surgical procedures during the log-term postoperative period, i.e. three and more months after the intervention. The materials for the study were brushings and histological biopsies; in addition, the functional parameters of the mucous membranes of the nose and maxillary sinuses were estimated before and after surgery. It has been found that the type of the surgical intervention on the inferior turbinate bones for the treatment of chronic rhinitis, such as gentle turbinotomy, has no significant influence on the state of the mucous membrane...
2016: Vestnik Otorinolaringologii
https://www.readbyqxmd.com/read/27870664/targeting-il-25-as-a-novel-therapy-in-chronic-rhinosinusitis-with-nasal-polyps
#11
Mingyu Lee, Dae Woo Kim, Hyun-Woo Shin
PURPOSE OF REVIEW: Chronic rhinosinusitis with nasal polyps (CRSwNPs) is a heterogeneous inflammatory disorder with a poorly understood pathophysiology. Recent findings show that epithelial-derived cytokines, including thymic stromal lymphopoietin, IL-33, and IL-25, can exacerbate Th2 immune responses, ultimately leading to recalcitrant chronic rhinosinusitis and nasal polyp. Although IL-25 is increased in CRSwNP, the targeting of IL-25 as a therapeutic strategy remains largely unexplored...
November 18, 2016: Current Opinion in Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/27864672/rhinophototherapy-in-persistent-allergic-rhinitis
#12
Zsolt Bella, Ágnes Kiricsi, Éva Dósa-Rácz Viharosné, Attila Dallos, Ádám Perényi, Mária Kiss, Andrea Koreck, Lajos Kemény, József Jóri, László Rovó, Edit Kadocsa
Previous published results have revealed that Rhinolight(®) intranasal phototherapy is safe and effective in intermittent allergic rhinitis. The present objective was to assess whether phototherapy is also safe and effective in persistent allergic rhinitis. Thirty-four patients with persistent allergic rhinitis were randomized into two groups; twenty-five subjects completed the study. The Rhinolight(®) group was treated with a combination of UV-B, UV-A, and high-intensity visible light, while the placebo group received low-intensity visible white light intranasal phototherapy on a total of 13 occasions in 6 weeks...
November 18, 2016: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/27864285/il-23-secreted-by-bronchial-epithelial-cells-contributes-allergic-sensitization-in-asthma-model
#13
Hyun Seung Lee, Da-Eun Park, Ji-Won Lee, Yuna Chang, Hye Young Kim, Woo-Jung Song, Hye-Ryun Kang, Heung-Woo Park, Yoon-Seok Chang, Sang-Heon Cho
BACKGROUND: IL-23 has been postulated to be a critical mediator contributing to various inflammatory diseases. Dermatophagoides pteronyssinus (Der p) is one of the most common inhalant allergens. However, the role of IL-23 in Der p-induced mouse asthma model is not well understood, particularly with regard to the development of allergic sensitization in the airways. OBJECTIVE: To evaluate roles of IL-23 in Der p-sensitization and asthma development. METHODS: BALB/c mice were repeatedly administered with Der p intra-nasally to develop Der p-allergic sensitization and asthma...
November 18, 2016: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://www.readbyqxmd.com/read/27860365/fetal-development-of-the-incisive-canal-especially-of-the-delayed-closure-due-to-the-nasopalatine-duct-a-study-using-serial-sections-of-human-fetuses
#14
Ji Hyun Kim, Kyoko Oka, Zhe Wu Jin, Gen Murakami, José Francisco Rodríguez-Vázquez, Sung Woo Ahn, Hong Pil Hwang
The incisive canal of the incisive bone or premaxilla is a narrow bony canal through which pass the nasopalatine nerve and its concomitant vessels. However, its fetal development remains obscure. To assess its development, serial frontal sections of the heads of 26 human fetuses, of gestational age 9-20 weeks (crown-rump length, 46-183 mm), were examined. The nerve initially passed through a wide loose tissue space, but after ossification of the upper part of the incisive bone at 12-15 weeks, the canal became narrow and filled with tight fibrous tissue...
November 18, 2016: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
https://www.readbyqxmd.com/read/27853945/endoscopic-closure-of-large-septal-perforations-with-bilateral-hadad-bassagasteguy-flaps
#15
Eduardo Morera Serna, Luis Ferrán de la Cierva, Meritxell Tomás Fernández, Santiago Quer Canut, Jacoba Alba Mesquida, Francisco José García Purriños
: Surgical closure of nasal septal perforations is one of the most challenging procedures in nasal surgery. Defects greater than 2 cm are especially difficult to repair with the traditional approaches due to the challenges of mobilizing enough mucosa to close big gaps, and avoiding airway stenosis in the process. We present a new technique to endoscopically close major septal perforations using bilateral Hadad-Bassagasteguy flaps. Four consecutive patients with septal perforations greater than 2 cm were operated at our institution...
November 16, 2016: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/27825650/development-of-a-multi-matrix-lc-ms-ms-method-for-urea-quantitation-and-its-application-in-human-respiratory-disease-studies
#16
Jianshuang Wang, Yang Gao, Drew W Dorshorst, Fang Cai, Meire Bremer, Dennis Milanowski, Tracy L Staton, Stephanie S Cape, Brian Dean, Xiao Ding
In human respiratory disease studies, liquid samples such as nasal secretion (NS), lung epithelial lining fluid (ELF), or upper airway mucosal lining fluid (MLF) are frequently collected, but their volumes often remain unknown. The lack of volume information makes it hard to estimate the actual concentration of recovered active pharmaceutical ingredient or biomarkers. Urea has been proposed to serve as a sample volume marker because it can freely diffuse through most body compartments and is less affected by disease states...
January 30, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/27825300/identification-of-novel-and-differentially-expressed-micrornas-in-goat-enzootic-nasal-adenocarcinoma
#17
Bin Wang, Ni Ye, San-Jie Cao, Xin-Tian Wen, Yong Huang, Qi-Gui Yan
BACKGROUND: MicroRNAs (miRNAs) post-transcriptionally regulate a variety of genes involved in eukaryotic cell growth, development, metabolism and other biological processes, and numerous miRNAs are implicated in the initiation and progression of cancer. Enzootic nasal adenocarcinoma (ENA), an epithelial tumor induced in goats and sheep by enzootic nasal tumor virus (ENTV), is a chronic, progressive, contact transmitted disease. METHODS: In this work, small RNA Illumina high-throughput sequencing was used to construct a goat nasal miRNA library...
November 8, 2016: BMC Genomics
https://www.readbyqxmd.com/read/27820923/the-proinflammatory-potential-of-nitrogen-dioxide-and-its-influence-on-the-house-dust-mite-allergen-der-p-1
#18
Christian Koehler, Michael Paulus, Christian Ginzkey, Stephan Hackenberg, Agmal Scherzad, Pascal Ickrath, Rudolf Hagen, Norbert Kleinsasser
Asthma and allergies are both major global health problems with an increasing prevalence, and environmental data implicate an influence of air pollutants on their development. The present study focuses on the influence of nitrogen dioxide (NO2) and the major allergen of the house dust mite Der p 1 on human nasal epithelial cells of nonallergic patients in vitro. Nasal epithelial mucosa samples of 11 donors were harvested during nasal air passage surgery and cultured as an air-liquid interface. Exposure to 0...
2016: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/27817798/advances-in-rhinitis-and-rhinosinusitis-in-2015
#19
REVIEW
Claus Bachert, Elien Gevaert
The last year has seen great progress in the understanding of upper airway disease and in its management. For allergic rhinitis, authors focused on the prediction of and effect on the natural course of disease. New evidence was published for the disease-modifying effect of allergen immunotherapy in terms of avoidance of new sensitizations and prevention of asthma in either randomized or real-life studies. Specifically, for patients with house dust mite allergies, which are often underestimated and difficult to diagnose, the efficacy of SQ house dust mite sublingual immunotherapy tablets has been demonstrated in patients with allergic rhinitis and asthma...
November 2016: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/27812543/duox1-mediates-persistent-epithelial-egfr-activation-mucous-cell-metaplasia-and-airway-remodeling-during-allergic-asthma
#20
Aida Habibovic, Milena Hristova, David E Heppner, Karamatullah Danyal, Jennifer L Ather, Yvonne M W Janssen-Heininger, Charles G Irvin, Matthew E Poynter, Lennart K Lundblad, Anne E Dixon, Miklos Geiszt, Albert van der Vliet
Chronic inflammation with mucous metaplasia and airway remodeling are hallmarks of allergic asthma, and these outcomes have been associated with enhanced expression and activation of EGFR signaling. Here, we demonstrate enhanced expression of EGFR ligands such as amphiregulin as well as constitutive EGFR activation in cultured nasal epithelial cells from asthmatic subjects compared with nonasthmatic controls and in lung tissues of mice during house dust mite-induced (HDM-induced) allergic inflammation. EGFR activation was associated with cysteine oxidation within EGFR and the nonreceptor tyrosine kinase Src, and both amphiregulin production and oxidative EGFR activation were diminished by pharmacologic or genetic inhibition of the epithelial NADPH oxidase dual oxidase 1 (DUOX1)...
November 3, 2016: JCI Insight
keyword
keyword
115735
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"