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Thyroid rct children

Carmen L Soto-Rivera, Michael S D Agus, Jaclyn E Sawyer, Duncan J Macrae
OBJECTIVE: To provide an overview of the current literature on the use of hormone replacement therapies in pediatric cardiac critical care. DATA SOURCES: PubMed, EMBASE, and the Cochrane Library were searched using keywords relevant to the hormonal therapy, with no limits on language but restricting the search to children 0-18 years old. STUDY SELECTION: All clinical studies believed to have relevance were considered. Where studies in children were sparse, additional evidence was sought from adult studies...
March 2016: Pediatric Critical Care Medicine
Saliha Kanık Yüksek, Zehra Aycan, Özgür Öner
OBJECTIVE: To investigate the incidence of iodine deficiency (ID) and its effects on mental function in children referred to the Dr. Sami Ulus Maternity and Children's Training and Research Hospital with a prospective diagnosis of attention deficit/hyperactivity disorder (ADHD). METHODS: The study was conducted on 89 children referred in the period from September 2009 to June 2010 with a diagnosis of ADHD. A questionnaire was given to all parents. Conners' rating scales were applied to the parents (CPRS) and teachers (CTRS), and revised Wechsler intelligence scale for children (WISC-R) to the children...
March 5, 2016: Journal of Clinical Research in Pediatric Endocrinology
Xi Jin, Liam Masterson, Anant Patel, Liz Hook, James Nicholson, Sarah Jefferies, Mark Gaze, Ramez Nassif, Robert Eller, Tony Hulse, Piyush Jani
BACKGROUND: Pediatric papillary thyroid carcinoma (PTC) is characterized by an aggressive clinical course. Early diagnosis is a challenge and treatment consists principally of partial or total thyroidectomy±neck dissection and radioactive iodine therapy. Due to the rarity of PTC in children, there is no consensus on optimal surgical treatment. METHODS AND RESULTS: A literature search was carried out using PubMed, Embase, Medline, Cochrane and Web of Science. Seven studies (489 patients) investigating the outcome of surgically managed pediatric PTC were identified...
October 2015: International Journal of Pediatric Otorhinolaryngology
Helmuth G Dörr, Markus Bettendorf, Gerhard Binder, Beate Karges, Carolin Kneppo, Heinrich Schmidt, Egbert Voss, Martin Wabitsch, Jörg Dötsch
BACKGROUND: Levothyroxine (L-T4) treatment of euthyroid children with Hashimoto thyroiditis (HT) is a controversial issue. PATIENTS AND METHODS: We conducted a prospective, randomized, controlled clinical trial. Out of 79 identified euthyroid patients, 59 started the study; 25 patients (21 female, 4 male; age: 11.8 ± 2.3 years) received L-T4 at a mean dose of 1.6 µg/kg (SD, 0.8) daily, and 34 (27 female, 7 male; age: 12.6 ± 1.2 years) were not treated. Patients developing subclinical hypothyroidism during follow-up (n = 13) were treated with L-T4 and removed from the observation group...
2015: Hormone Research in Pædiatrics
Margaret P Rayman, Sarah C Bath
Adequate iodine intake is important during pregnancy as it is a component of the thyroid hormones that are crucial for fetal brain and neurological development. While randomized controlled trials in severe iodine deficiency have shown that iodine deficiency in pregnancy causes impaired offspring cognition, less is known of the effects in regions of mild/mild-to-moderate deficiency. The United Kingdom is now classified as mildly iodine deficient by the World Health Organization, based on a 2011 national study of 14-15-year-old schoolgirls...
November 2015: Annals of Clinical Biochemistry
Debika Nandi-Munshi, Craig E Taplin
BACKGROUND: Thyroid hormones exert critical roles throughout the body and play an important and permissive role in neuroendocrine, neurological, and neuromuscular function. METHODS: We performed a PubMed search through June 2014 with search terms including "hypothyroidism," "hyperthyroidism," "neurological complications," "neuropathy," "myopathy," "congenital hypothyroidism," and "encephalopathy." Relevant publications reviewed included case series, individual case reports, systematic reviews, retrospective analyses, and randomized controlled trials...
April 2015: Pediatric Neurology
Danijela Ristić-Medić, Carla Dullemeijer, Jasna Tepsić, Gordana Petrović-Oggiano, Tamara Popović, Aleksandra Arsić, Marija Glibetić, Olga W Souverein, Rachel Collings, Adriënne Cavelaars, Lisette de Groot, Pieter van't Veer, Mirjana Gurinović
The objective of this systematic review was to identify studies investigating iodine intake and biomarkers of iodine status, to assess the data of the selected studies, and to estimate dose-response relationships using meta-analysis. All randomized controlled trials, prospective cohort studies, nested case-control studies, and cross-sectional studies that supplied or measured dietary iodine and measured iodine biomarkers were included. The overall pooled regression coefficient (β) and the standard error of β were calculated by random-effects meta-analysis on a double-log scale, using the calculated intake-status regression coefficient (β) for each individual study...
March 2014: Nutrition Reviews
Shao J Zhou, Amanda J Anderson, Robert A Gibson, Maria Makrides
BACKGROUND: Routine iodine supplementation during pregnancy is recommended by leading health authorities worldwide, even in countries where the iodine status of the population is sufficient. OBJECTIVES: We evaluated the efficacy and safety of iodine supplementation during pregnancy or the periconceptional period on the development and growth of children. Secondary outcomes included pregnancy outcome and thyroid function. DESIGN: A systematic review of randomized controlled trials (RCTs) was conducted...
November 2013: American Journal of Clinical Nutrition
Danijela Ristić-Medić, Romana Novaković, Maria Glibetić, Mirjana Gurinović
Iodine is an essential component of thyroid hormones, and current recommendations for intake are based on urinary iodine excretion, assessment of thyroid size, thyroidal iodine accumulation and turnover, radioactive iodine uptake, balance studies, and epidemiological studies. Dietary iodine is rapidly and almost completely absorbed. The prevalence of inadequate iodine intake is high: 29% of the world's population lives in iodine-deficient areas and 44% of Europe remains mildly iodine deficient. To assess current data and update evidence for setting dietary recommendations for iodine, the EURRECA Network of Excellence has undertaken systematic review and evaluation of (i) the usefulness of iodine status biomarkers (ii) the relationship between iodine status biomarkers and dietary iodine intake, and (iii) the relationship between iodine intake and health outcomes (endemic goiter, hypothyroidism, and cognitive function)...
2013: Critical Reviews in Food Science and Nutrition
K King, C O'Gorman, S Gallagher
INTRODUCTION: This article is an evidence-based review of thyroid disease in children with Down syndrome, including a comparison between various professional guidelines for the management of thyroid disease in children with Down syndrome. Aspects of thyroid disease which are discussed include: congenital hypothyroidism; autoimmune thyroid disease; subclinical hypothyroidism; and hyperthyroidism. The national professional guidelines of Ireland, the United Kingdom, the United States of America, Australia and Canada are reviewed and compared...
March 2014: Irish Journal of Medical Science
(no author information available yet)
UNLABELLED: OBJECTIVE OF ANALYSIS: The objective of this evidence-based evaluation is to assess the accuracy of serologic tests in the diagnosis of celiac disease in subjects with symptoms consistent with this disease. Furthermore the impact of these tests in the diagnostic pathway of the disease and decision making was also evaluated. CELIAC DISEASE: Celiac disease is an autoimmune disease that develops in genetically predisposed individuals. The immunological response is triggered by ingestion of gluten, a protein that is present in wheat, rye, and barley...
2010: Ontario Health Technology Assessment Series
Marijke Gielen, Dieter Mesotten, Pieter J Wouters, Lars Desmet, Dirk Vlasselaers, Ilse Vanhorebeek, Lies Langouche, Greet Van den Berghe
CONTEXT: Tight glucose control (TGC) to normal-for-age fasting blood glucose levels reduced morbidity and mortality in surgical adult and pediatric intensive care unit (ICU) patients. In adults, TGC did not affect the illness-induced alterations in thyroid hormones. With better feeding in children than in adult patients, we hypothesized that TGC in pediatric ICU patients reactivates the thyroid axis. OBJECTIVE: The aim of this study was to assess the impact of TGC on the thyroid axis in pediatric ICU patients and to investigate how these changes affect the TGC outcome benefit...
October 2012: Journal of Clinical Endocrinology and Metabolism
Akhgar Ghassabian, Henning Tiemeier
During the past decades, observational studies have demonstrated a relationship between thyroid dysfunction in pregnancy and a range of adverse outcomes in both mother and offspring. However, results from the few randomized trials of screening for thyroid dysfunction in pregnant women have not shown any benefit for women or their children. Before implementing screening in pregnant women at population level, randomized trials are needed to show that screening with subsequent intervention is effective for mothers or children...
December 2012: Clinical Endocrinology
Roberto Negro, Offie P Soldin, Maria-Jesus Obregon, Alex Stagnaro-Green
OBJECTIVE: To evaluate the peer-reviewed literature on iodine deficiency and hypothyroxinemia in pregnancy. METHODS: We review published studies on isolated hypothyroxinemia in pregnancy, methodology of free thyroxine (T4) assays, impact of iodine deficiency on free T4 levels, and status of ongoing prospective randomized trials of isolated hypothyroxinemia during pregnancy. RESULTS: Hypothyroxinemia during pregnancy is common. Studies have demonstrated the pivotal role exerted by maternal T4 on fetal brain development and the negative impact of hypothyroxinemia on neurobehavioral performance in offspring...
May 2011: Endocrine Practice
Rei Ogawa, Sumiko Yoshitatsu, Ken Yoshida, Tsuguhiro Miyashita
BACKGROUND: Keloids have been treated by using radiation for over a century, and it is currently suggested that keloids are best treated by a combination of surgery and postoperative radiation therapy, although randomized controlled trials testing this are still lacking. However, plastic surgeons tend to avoid radiation therapy for keloids for fear of inducing malignant tumors. Thus, the authors searched for previous reports of associations between carcinogenesis and keloid radiation therapy, and examined the evidence-based opinions of radiation oncologists regarding the acceptability of using radiation to treat keloids...
October 2009: Plastic and Reconstructive Surgery
Danijela Ristic-Medic, Zlata Piskackova, Lee Hooper, Jiri Ruprich, Amélie Casgrain, Kate Ashton, Mirjana Pavlovic, Maria Glibetic
BACKGROUND: Biomarkers of iodine status are required to study iodine deficiency disorders in different parts of the world and to evaluate the effects of fortification strategies. OBJECTIVE: The objective was to assess the usefulness of biomarkers of iodine status in humans by systematically reviewing intervention studies that altered iodine status. DESIGN: We performed a structured search for iodine intervention studies on Ovid MEDLINE, EMBASE (Ovid), and the Cochrane Library...
June 2009: American Journal of Clinical Nutrition
Beate Karges, Rainer Muche, Ina Knerr, Waldemar Ertelt, Thomas Wiesel, Regine Hub, Andreas Neu, Albrecht Klinghammer, Julia Aufschild, Andrea Rapp, Andreas Schirbel, Bernhard O Boehm, Klaus M Debatin, Eberhard Heinze, Wolfram Karges
CONTEXT: Patients with type 1 diabetes (T1D) have an increased risk of autoimmune thyroiditis (AIT). OBJECTIVE: Our objective was to determine whether levothyroxine (l-T(4)) treatment prevents the clinical manifestation of AIT in euthyroid subjects with T1D. DESIGN AND SETTING: We conducted a prospective, randomized, open, controlled clinical trial at six tertiary care centers for pediatric endocrinology and diabetes. PATIENTS: Of 611 children and adolescents with T1D, 89 individuals (14...
May 2007: Journal of Clinical Endocrinology and Metabolism
D A Osborn, R W Hunt
BACKGROUND: Observational studies have shown an association between transiently low thyroid hormone levels in preterm infants in the first weeks of life (transient hypothyroxinaemia) and abnormal neurodevelopmental outcome. Thyroid hormone replacement might prevent this. OBJECTIVES: To determine whether prophylactic thyroid hormones given to preterm infants without congenital hypothyroidism result in clinically important changes in neonatal and long term outcomes...
2007: Cochrane Database of Systematic Reviews
Aleid G van Wassenaer, Jolanda Westera, Bregje A Houtzager, Joke H Kok
BACKGROUND: Thyroid hormones are essential for brain development. We conducted a randomized, controlled trial with thyroxine (T4) supplementation in infants <30 weeks' gestation and with the last neurodevelopmental follow-up moment at the age of 5.5 years. T4 supplementation was associated with improved outcome of infants <28 weeks' gestation and worse outcome of infants of 29 weeks' gestation. We studied gestational age-dependent effects of T4 supplementation at the mean age of 10...
November 2005: Pediatrics
Charmian A Quigley, Anne M Gill, Brenda J Crowe, Kristen Robling, John J Chipman, Susan R Rose, Judith L Ross, Fernando G Cassorla, Anne M Wolka, Jan M Wit, Lyset T M Rekers-Mombarg, Gordon B Cutler
CONTEXT: Recombinant human GH was approved by the United States Food and Drug Administration in 2003 for the treatment of idiopathic short stature (ISS). However, to date, the safety of GH in this patient population has not been rigorously studied. OBJECTIVE: The objective of this study was to address the safety of GH treatment in children with ISS compared with GH safety in patient populations for which GH has been approved previously: Turner syndrome (TS) and GH deficiency (GHD)...
September 2005: Journal of Clinical Endocrinology and Metabolism
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