Nathan Kuppermann, Simona Ghetti, Jeff E Schunk, Michael J Stoner, Arleta Rewers, Julie K McManemy, Sage R Myers, Lise E Nigrovic, Aris Garro, Kathleen M Brown, Kimberly S Quayle, Jennifer L Trainor, Leah Tzimenatos, Jonathan E Bennett, Andrew D DePiero, Maria Y Kwok, Clinton S Perry, Cody S Olsen, T Charles Casper, J Michael Dean, Nicole S Glaser
BACKGROUND: Diabetic ketoacidosis in children may cause brain injuries ranging from mild to severe. Whether intravenous fluids contribute to these injuries has been debated for decades. METHODS: We conducted a 13-center, randomized, controlled trial that examined the effects of the rate of administration and the sodium chloride content of intravenous fluids on neurologic outcomes in children with diabetic ketoacidosis. Children were randomly assigned to one of four treatment groups in a 2-by-2 factorial design (0...
June 14, 2018: New England Journal of Medicine