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correlation of diabetic retinopathy and ischemic heart disease

Jitka Brožová, Daniela Čechurová, Silvie Lacigová
Aim of this retrospective observational study was to determine the prevalence of metabolic syndrome (MS) in patients with diabetes mellitus type 1 (DM1Z) at baseline (in 2003) and find the parameters that determine the difference between group with (MS+) and without MS (MS-). Did the presence of MS affect morbidity and mortality in the subsequent 10 years? METHODS: 278 patients were enrolled to the study with age average 39 ± 13 years with medical history of diabetes 15.9 ± 9 years...
2016: Vnitr̆ní Lékar̆ství
Miao Liu, Yihe Li, Jiaqi Li, Xianyu Lv, Yao He
AIMS: This study aimed to evaluate the association between total bilirubin (TBiL) and major diabetic complications among Chinese senile diabetic patients. METHODS: A cross-sectional study was conducted in all the cadre sanitariums in Beijing, between May 2012 and December 2014. All the diagnoses of diabetic complications were extracted from the medical records including chronic kidney disease, retinopathy, peripheral vascular disease, coronary heart disease, and ischemic stroke...
January 2017: Journal of Diabetes and its Complications
Eva Aguilera, Enric Serra-Planas, M Luisa Granada, Silvia Pellitero, Jordi L Reverter, Núria Alonso, Berta Soldevila, Dídac Mauricio, Manel Puig-Domingo
BACKGROUND: The glycoprotein YKL-40 is a new marker of early inflammation and endothelial dysfunction. Adiponectin is a collagen-like protein with anti-atherogenic and anti-inflammatory effects. Increased concentrations of both markers have been reported in patients with type 1 diabetes (T1D). AIM: To assess the possible role of YKL-40 and adiponectin as a marker of subclinical cardiovascular disease in asymptomatic patients with type 1 diabetes with no history of ischemic or macrovascular heart disease and its relationship with other classic inflammatory biomarkers...
September 18, 2015: Cardiovascular Diabetology
Faranak Sharifi, Yahya Jaberi, Fatemeh Mirzamohammadi, Hamid Mirzamohammadi, Nouraddin Mousavinasab
AIMS: To detect the risk factors of diabetes mellitus (DM) and cardiovascular complications in subjects with impaired fasting glucose (IFG). MATERIALS AND METHODS: One hundred and twenty three subjects with proved IFG in Zanjan Healthy Heart Study (2002-2003) were recalled and participated in this study (2009-2010). Demographic and laboratoryinformation of the participants were collected.Ischemic heart disease (IHD) was assessed by the exercise tolerance test (ETT)...
September 2013: Indian Journal of Endocrinology and Metabolism
Anthony J Viera, Micah Mooberry, Nigel S Key
Microparticles (MPs) are vesicles less than one micron in diameter shed from the plasma membranes of cells that are injured, activated, or undergoing apoptosis. MPs are shed from several types of cells, and the cells of origin can be identified using combinations of antigenic markers. Platelet MPs, which play a role in coagulation and atherogenesis, are the most abundant MPs in the circulation. In vivo studies have demonstrated platelet MP levels to be higher in patients who have had acute ischemic stroke and in patients with greater degrees of retinopathy...
July 2012: Journal of the American Society of Hypertension: JASH
Mohammadreza Peyman, Iqbal Tajunisah, Angela Loo, Khai Choon Chuah, Visvaraja Subrayan
To correlate Heidelberg Retina Tomograph (HRT) derived macular edema (DME) index with severity of diabetic retinopathy and systemic factors. A total of 300 diabetic patients were recruited for the study for each of them a value for the macular edema index was obtained using the HRT II. Patients' age, gender, duration and type of diabetes mellitus, latest HbA1c result and presence or absence of co-morbid factors (hypertension, ischemic heart disease, nephropathy) were recorded together with the stage of diabetic retinopathy...
May 2012: Journal of Diabetes and its Complications
John M Wentworth, Spiros Fourlanos, Peter G Colman
AIMS: Comprehensive data describing the effect of obesity on type 2 diabetes outcomes is lacking. We sought to address this by analyzing a tertiary hospital clinical database. METHODS: We extracted clinical and biochemical data for patients who attended a tertiary hospital diabetes clinic between 1998 and 2011 and were aged less than 65 years. Body mass index (BMI) was correlated with the prevalence of vascular complications and with cardiovascular risk factors...
July 2012: Diabetes Research and Clinical Practice
S Vigili de Kreutzenberg, A Coracina, A Volpi, G P Fadini, A C Frigo, G Guarneri, A Tiengo, A Avogaro
BACKGROUND AND AIMS: Common mechanisms for the development of micro- and macroangiopathic diabetic complications have been suggested. We aimed to cross-sectionally investigate strength and characteristics of the association between carotid atherosclerosis and microangiopathy in type 2 diabetic patients. METHODS AND RESULTS: Common carotid artery intima-media thickness (cIMT), carotid plaque (CP) type and degree of stenosis were evaluated by ultrasound, along with the determination of anthropometric parameters, HbA1c, lipid profile, assessment of diabetic retinopathy and nephropathy, in 662 consecutive patients with type 2 diabetes mellitus (T2DM)...
April 2011: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
Hideo Kusuoka, Yoshimitsu Yamasaki, Tohru Izumi, Atsunori Kashiwagi, Ryuzo Kawamori, Kazuaki Shimamoto, Nobuhiro Yamada, Tsunehiko Nishimura
OBJECTIVE: Diabetes mellitus is an independent risk factor for acute myocardial infarction. Thus, a surveillance study was conducted as part of studies to create a national database related to electrocardiogram (ECG)-gated myocardial perfusion single-photon emission computed tomography (SPECT) of ischemic heart disease. METHODS: Single-photon emission computed tomography was conducted in patients with type 2 diabetes mellitus and their prognoses will be followed for 3 years, stratified by patients' clinical background and SPECT findings...
January 2008: Annals of Nuclear Medicine
Maria Mota, Corina Lichiardopol, E Mota, Camelia Pănuş, A Pănuş
Erectile dysfunction (ED) is 2-3 times more frequent in men with diabetes mellitus than in men without such a history and might be an early marker of endothelial dysfunction. We studied a group of 310 unselected male patients within the Clinical Center of Diabetes and Metabolic Diseases of Dolj County, with ages ranging between 20-78 years (57.43 + 0.835) and a positive history of diabetes mellitus for 1-47 years (10.09 +/- 8.715). Erectile dysfunction, quantified using SHIM (Sexual Health Inventory for Men), was present in 196 patients (63...
2003: Romanian Journal of Internal Medicine, Revue Roumaine de Médecine Interne
David Hauser, Haia Katz, Russell Pokroy, Amir Bukelman, Edna Shechtman, Ayala Pollack
PURPOSE: To evaluate the risk factors associated with the occurrence and progression of diabetic retinopathy (DR) after phacoemulsification cataract surgery. SETTING: Department of Ophthalmology, Kaplan Medical Center, Rehovot, Israel. METHODS: The medical charts of 52 eyes of 48 consecutive patients who had phacoemulsification were retrospectively reviewed. The occurrence of DR (new development of any DR) and progression (DR requiring laser treatment) were correlated with patients' age, sex, duration of diabetes, control of diabetes, hypertension, ischemic heart disease, and surgical technique...
February 2004: Journal of Cataract and Refractive Surgery
Z Wagner, I Wittmann, I Mazák, R Schinzel, A Heidland, R Kientsch-Engel, J Nagy
Advanced glycation end products (AGEs) such as N(epsilon)-(carboxymethyl)lysine (CML) have been implicated in the development and progression of diabetic nephropathy. The aim of the present study is to investigate AGE levels in patients with type 2 diabetes with special regard to the role of renal impairment. Serum and urine CML levels (using a newly developed enzyme-linked immunosorbent assay), as well as serum AGE-fluorescence, were measured in 109 patients with type 2 diabetes. Patients were divided into groups with normal and impaired renal function...
October 2001: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
C Chang, F Lu, Y C Yang, J S Wu, T J Wu, M S Chen, L M Chuang, T Y Tai
Diabetes mellitus (DM) in adults is a global health problem, although its prevalence varies widely between different populations and the rate has generally increased worldwide. In Taiwan, the mortality rate from DM has almost doubled over the past 10 years. The prevalence of DM in Taiwan was established between 1985 and 1996 and the rates were between 4.9 and 9.2%. The prevalence of impaired glucose tolerance (IGT) was 15.5% (men 15% and women 15.9%). The prevalence of DM and IGT increased significantly with age for both genders...
October 2000: Diabetes Research and Clinical Practice
M Yoshida, J Takamatsu, S Yoshida, K Tanaka, K Takeda, H Higashi, H Kitaoka, N Ohsawa
This study was aimed at investigating the degree of calcification of coronary arteries in type II diabetes mellitus for the purpose of examining as risk factors for coronary disease as well as parameters of diabetic complications. One hundred and three patients with type II diabetes were studied by the newly developed noninvasive technology of electron beam computed tomography, in which the degree of calcification was expressed as coronary calcification scores. The mean +/- SE value of coronary calcification scores were 247...
October 1999: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
S Sugiyama, T Miyata, Y Ueda, H Tanaka, K Maeda, S Kawashima, C Van Ypersele de Strihou, K Kurokawa
Nonenzymatic reactions between glucose and proteins yield advanced glycation end products (AGE) such as pentosidine. AGE accumulate in diabetic patients, alter the structure and function of tissue proteins, stimulate cellular response, and have thus been implicated in diabetic tissue damage. The present study was undertaken to assess the factors determining plasma total pentosidine level in diabetic patients and the possible relation between plasma pentosidine level and diabetic complications. In diabetic patients, including patients with renal failure, plasma pentosidine levels, assessed by HPLC assay, were correlated with serum creatinine (P < 0...
September 1998: Journal of the American Society of Nephrology: JASN
R Takeda, M Shimizu
The risk of death by ischemic heart disease (IHD) in patients with diabetes mellitus is higher than in non-diabetics, and the average life span of the diabetics is shorter than in non-diabetics in Japan. There is no direct correlation between the occurrence of IHD and severity or glycemic control of diabetes. However, the mortality by IHD increases in diabetic patients with severe retinopathy and/or massive proteinuria. Regarding the management of IHD, diabetes is not considered a contraindication to thrombolytic therapy...
October 1994: Diabetes Research and Clinical Practice
T Onuma, T Kikuchi, M Shimura, M Tsutsui, J Matsui, A Boku, K Takebe
Relationship of the lipoprotein(a) [Lp(a)] concentration as a risk factor independent of other factors with the severity of diabetic retinopathy were evaluated by multiple regression analysis. The subjects were 158 patients with non-insulin-dependent diabetes mellitus (NIDDM). Multiple regression analysis was carried with the severity of diabetic retinopathy as the dependent variable and 13 independent variables, namely the Lp(a) concentration, sex, age, body mass index, duration of diabetes, ischemic heart disease, fasting plasma glucose, glycosylated hemoglobin A1c, total cholesterol, triglyceride, high-density lipoprotein cholesterol, anti-diabetic treatments, and diabetic nephropathy...
June 1994: Tohoku Journal of Experimental Medicine
N V Nielsen
The prevalence of glaucoma and ocular hypertension was investigated in an epidemiological study of diabetics traced by registration of prescriptions on insulin and oral hypoglycaemic agents (OHA) on the island of Falster (inhabitants 44 498), Denmark. Among 533 diabetics (227 insulin- and 306 OHA-treated) the prevalence rate of primary open angle glaucoma and ocular hypertension was 6.0% and 3.0%, respectively. Neovascular glaucoma occurred in 2.1% of all diabetics and in 21.3% of diabetics with proliferative retinopathy...
August 1983: Acta Ophthalmologica
P Pacuła, E Janeczko, D Trusiewicz, A Koneczna, M Tomaszczyk, K Dembe, D Stryjek-Kamińska
The authors made a retrospective analysis of late ineffectiveness of sulphonylurea derivatives and its correlation with the age of diabetes onset, duration of the disease, sex, body mass, smoking cigarettes, diabetes history in the family, coexistence with some diabetic complications as retinopathy, ischemic heart disease, arterial hypertension and vascular diseases in lower limbs. The study was carried out in a group of 220 patients with diabetes type 2 lasting from 1 up to 25 years, aged 30-77 undergoing therapy in the Department of Gastroenterology and Metabolic Diseases in the years 1976-1987 in whom a late ineffectiveness appeared to sulphonylurea derivatives...
April 1989: Polskie Archiwum Medycyny Wewnętrznej
I N Migdalis, V Iliopoulou, K Kalogeropoulou, K Koutoulidis, M Samartzis
Serum levels of angiotensin-converting enzyme (ACE) were measured in 53 patients with type II (non-insulin-dependent) diabetes (25 without ophthalmologic complications, 20 with background retinopathy, and eight with proliferative retinopathy) and in 33 healthy nondiabetic subjects. Diabetic subjects were excluded if they had hypertension, ischemic heart disease, peripheral vascular disease, or an elevated urine albumin level. After an overnight fast, blood was taken for determination of ACE, blood glucose, glycosylated hemoglobin (HbA1), and C peptide levels...
April 1990: Southern Medical Journal
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