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https://www.readbyqxmd.com/read/29150150/biocompatible-hollow-polymeric-particles-produced-by-a-mild-solvent-and-template-free-strategy
#1
Eustolia Rodríguez-Velázquez, Pablo Taboada, Manuel Alatorre-Meda
Macroscopic hollow polymeric particles are attractive materials for various applications such as surgery, food industry, agriculture, etc. However, protocols reporting their synthesis have hitherto made use of organic solvents and/or sacrificial templates, compromising the encapsulation of different bioactive compounds and the process yield. Here, millimeter-size, hollow polymeric particles were synthesized, for the first time, in a solvent- and template free manner onto superhydrophobic surfaces (SHS). The particles were produced upon assembly and double superficial crosslinking of liquid droplets of DNA and methacrylamide chitosan aqueous solutions (CH:MA), leading to liquid-core particles with a hardened hydrogel shell...
November 14, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29114981/ptab-a-lim-domain-binding-protein-in-aspergillus-fumigatus-regulates-biofilm-formation-and-conidiation-through-distinct-pathways
#2
Shizhu Zhang, Yuan Chen, Zhihua Ma, Qiuyi Chen, Hanna Ostapska, Fabrice N Gravelat, Ling Lu, Donald C Sheppard
The exopolysaccharide galactosaminogalactan (GAG) plays an important role in mediating adhesion, biofilm formation and virulence in the pathogenic fungus Aspergillus fumigatus. The developmental modifiers MedA, StuA and SomA regulate GAG biosynthesis, but the mechanisms underlying this regulation are poorly understood. PtaB is a lim-domain binding protein that interacts with the transcription factor SomA and is required for normal conidiation and biofilm formation. Disruption of ptaB resulted in impaired GAG production and conidiation in association with a markedly reduced expression of GAG biosynthetic genes (uge3 and agd3), developmental regulators (medA and stuA), and genes involved in the core conidiation pathway...
November 7, 2017: Cellular Microbiology
https://www.readbyqxmd.com/read/29102605/development-and-clinical-accuracy-of-a-new-intraocular-lens-power-formula-vrf-compared-to-other-formulas
#3
Oleksiy V Voytsekhivskyy
PURPOSE: To develop and compare the accuracy and reproducibility of the VRF intraocular lens (IOL) power calculation formula with well-known methods. DESIGN: Development and validation study. METHODS: This analysis comprised 823 eyes of 823 patients at Kiev Clinical Ophthalmology Hospital Eye Microsurgery Center, Kiev, Ukraine, operated on by 1 surgeon with 3 different types of hydrophobic lenses: IQ SN60WF (494 eyes) and ReSTOR SN6AD1 (169 eyes) (Alcon Labs, Fort Worth, Texas, USA) and AMO Tecnis MF ZMB00 (160 eyes) (J&J Vision, Santa Ana, California, USA)...
November 2, 2017: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/29076784/direct-versus-indirect-revascularization-in-the-treatment-of-moyamoya-disease
#4
Seong-Eun Park, Ju-Seong Kim, Eun Kyung Park, Kyu-Won Shim, Dong-Seok Kim
OBJECTIVE For patients with moyamoya disease (MMD), surgical intervention is usually required because of progressive occlusion of the internal carotid artery. The indirect bypass method has been widely accepted as the treatment of choice in pediatric patients. However, in adult patients with MMD, the most effective treatment method remains a matter of debate. Here, the authors compared the clinical outcomes from MMD patients treated with either extracranial-intracranial arterial bypass (EIAB; 43 hemispheres) or modified encephaloduroarteriosynangiosis (mEDAS; 75 hemispheres) to investigate whether mEDAS is an effective surgical method for treating adults with symptomatic MMD...
October 27, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29069036/communication-skills-in-pediatrics-the-relationship-between-pediatrician-and-child
#5
Cristina Oana Mărginean, Lorena Elena Meliţ, Mihaela Chinceşan, Simona Mureşan, Anca Meda Georgescu, Nicoleta Suciu, Anisoara Pop, Leonard Azamfirei
Interpersonal and communication skills are 2 essential qualities of every physician. These are separate and distinct parts of the professional character of every physician. In pediatrics these abilities present even a higher impact.We performed a survey-type prospective study based on questionnaires on 100 subjects, equally divided into 4 groups: 25 children, 25 pediatricians, 25 care-givers (parents, tutors, and relatives), and 25 health care staff, in a Tertiary Pediatric Clinic from Romania, between January 2017 and April 2017...
October 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29056493/genetic-analysis-of-deep-phenotyping-projects-in-common-disorders
#6
REVIEW
Elliot S Gershon, Godfrey Pearlson, Matcheri S Keshavan, Carol Tamminga, Brett Clementz, Peter F Buckley, Ney Alliey-Rodriguez, Chunyu Liu, John A Sweeney, Sarah Keedy, Shashwath A Meda, Neeraj Tandon, Rebecca Shafee, Jeffrey R Bishop, Elena I Ivleva
Several studies of complex psychotic disorders with large numbers of neurobiological phenotypes are currently under way, in living patients and controls, and on assemblies of brain specimens. Genetic analyses of such data typically present challenges, because of the choice of underlying hypotheses on genetic architecture of the studied disorders and phenotypes, large numbers of phenotypes, the appropriate multiple testing corrections, limited numbers of subjects, imputations required on missing phenotypes and genotypes, and the cross-disciplinary nature of the phenotype measures...
October 20, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/29053847/effect-of-low-incubation-temperature-and-low-ambient-temperature-until-21-days-of-age-on-performance-and-body-temperature-in-fast-growing-chickens
#7
D Nyuiadzi, A Travel, B Méda, C Berri, L A Guilloteau, V Coustham, Y Wang, J K Tona, A Collin
Thermal manipulation during embryogenesis was previously reported to decrease the occurrence of ascites and to potentially improve cold tolerance of broilers. The objective of our study was to explore the effects of the interaction of cold incubation temperatures and cool ambient temperatures until 21 d of age on performance and body temperature. Ross 308 eggs were incubated either under control conditions I0 (37.6°C) or with cyclic cold stimulations I1 (6 h/d at 36.6°C from d 10 to 18 of incubation) or with 2 cold stimulations I2 (30 min at 15°C) at d 18 and 19 of incubation...
October 10, 2017: Poultry Science
https://www.readbyqxmd.com/read/29036228/factors-associated-to-acceptable-treatment-adherence-among-children-with-chronic-kidney-disease-in-guatemala
#8
Brooke M Ramay, Alejandro Cerón, Luis Pablo Méndez-Alburez, Randall Lou-Meda
Pediatric patients with Chronic Kidney Disease face several barriers to medication adherence that, if addressed, may improve clinical care outcomes. A cross sectional questionnaire was administered in the Foundation for Children with Kidney Disease (FUNDANIER, Guatemala City) from September of 2015 to April of 2016 to identify the predisposing factors, enabling factors and need factors related to medication adherence. Sample size was calculated using simple random sampling with a confidence level of 95%, confidence interval of 0...
2017: PloS One
https://www.readbyqxmd.com/read/29033801/heavy-drinking-in-college-students-is-associated-with-accelerated-gray-matter-volumetric-decline-over-a-2-year-period
#9
Shashwath A Meda, Alecia D Dager, Keith A Hawkins, Howard Tennen, Sarah Raskin, Rebecca M Wood, Carol S Austad, Carolyn R Fallahi, Godfrey D Pearlson
Background: Heavy and/or harmful alcohol use while in college is a perennial and significant public health issue. Despite the plethora of cross-sectional research suggesting deleterious effects of alcohol on the brain, there is a lack of literature investigating the longitudinal effects of alcohol consumption on the adolescent brain. We aim to probe the longitudinal effects of college drinking on gray matter change in students during this crucial neurodevelopmental period. Methods: Data were derived from the longitudinal Brain and Alcohol Research in College Students (BARCS) study of whom a subset underwent brain MRI scans at two time points 24 months apart...
2017: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/28982669/targeting-cx40-connexin40-expression-or-function-reduces-angiogenesis-in-the-developing-mouse-retina
#10
Jacques-Antoine Haefliger, Florent Allagnat, Lauriane Hamard, Loïc Le Gal, Paolo Meda, Denise Nardelli-Haefliger, Elisabeth Génot, Florian Alonso
OBJECTIVE: Cx40 (Connexin40) forms intercellular channels that coordinate the electric conduction in the heart and the vasomotor tone in large vessels. The protein was shown to regulate tumoral angiogenesis; however, whether Cx40 also contributes to physiological angiogenesis is still unknown. APPROACH AND RESULTS: Here, we show that Cx40 contributes to physiological angiogenesis. Genetic deletion of Cx40 leads to a reduction in vascular growth and capillary density in the neovascularization model of the mouse neonatal retina...
November 2017: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/28979638/-fight-against-maternal-mortality-in-rural-areas-decentralization-of-emergency-obstetric-cares-in-burkina-faso
#11
Souleymane Kaboré, Clément Ziemlé Méda, Issiaka Sombié, Léon Blaise Savadogo, Robert Karama, Koabié Bakouan, Djénéba Sanon Ouédraogo, Norbert Coulibaly, Robert Lucien Kargougou, Emanuel Lankoandé, Ramatou Windsouri Sawadogo, Karen Gosch
INTRODUCTION: In order to cover the shortage of midwives (MWs) in the health district of Tougan, Burkina Faso, a strategy for the decentralization of emergency obstetric cares, based on ad hoc interventions undertaken by MW to manage obstetric complications in health centers (HCs), has been developed in rural areas. This study aimed to describe this experience and to analyze the achieved results. METHODS: We conducted a cross-sectional, analytical, intervention study based on a review of routine data from all the parturients treated from 2013 to 2015...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28976321/droplet-size-aware-and-error-correcting-sample-preparation-using-micro-electrode-dot-array-digital-microfluidic-biochips
#12
Zipeng Li, Kelvin Yi-Tse Lai, Krishnendu Chakrabarty, Tsung-Yi Ho, Chen-Yi Lee
Sample preparation in digital microfluidics refers to the generation of droplets with target concentrations for on-chip biochemical applications. In recent years, digital microfluidic biochips (DMFBs) have been adopted as a platform for sample preparation. However, there remain two major problems associated with sample preparation on a conventional DMFB. First, only a (1:1) mixing/splitting model can be used, leading to an increase in the number of fluidic operations required for sample preparation. Second, only a limited number of sensors can be integrated on a conventional DMFB; as a result, the latency for error detection during sample preparation is significant...
September 29, 2017: IEEE Transactions on Biomedical Circuits and Systems
https://www.readbyqxmd.com/read/28969656/inadequate-programming-insufficient-communication-and-non-compliance-with-the-basic-principles-of-maternal-death-audits-in-health-districts-in-burkina-faso-a-qualitative-study
#13
Boukaré Congo, Djénéba Sanon, Tieba Millogo, Charlemagne Marie Ouedraogo, Wambi Maurice E Yaméogo, Ziemlé Clement Meda, Seni Kouanda
BACKGROUND: Implementation of quality maternal death audits requires good programming, good communication and compliance with core principles. Studies on compliance with core principles in the conduct of maternal death audits (MDAs) exist but were conducted in urban areas, at the 2nd or 3rd level of the healthcare system, in experimental situations, or in a context of skills-building projects or technical platforms with an emphasis on the review of "near miss". This study aims to fill the gap of evidence on the implementation of MDAs in rural settings, at the first level of care and in the routine care situation in Burkina Faso...
September 29, 2017: Reproductive Health
https://www.readbyqxmd.com/read/28964998/effect-of-pseudomonas-graminis-strain-cpa-7-on-the-ability-of-listeria-monocytogenes-and-salmonella-enterica-subsp-enterica-to-colonize-caco-2-cells-after-pre-incubation-on-fresh-cut-pear
#14
Cyrelys Collazo, Maribel Abadías, Pilar Colás-Medà, María Belén Iglesias, Ana Belén Granado-Serrano, José Serrano, Inmaculada Viñas
To further gain insight into the mechanism by which the biopreservative bacterium Pseudomonas graminis CPA-7 develops its antimicrobial activity, we have examined the effect that the prior interaction stablished by this bacterium and two foodborne pathogens on fresh-cut pear, has on their capacity to colonize human epithelial cells (Caco-2 cell line) which is crucial for establishing infection. CPA-7 inhibited the growth of L. monocytogenes and S. enterica subsp. enterica ser. Enteritidis by 5.5 and 3.1 log10, respectively, after 7d of interaction at 10°C...
December 4, 2017: International Journal of Food Microbiology
https://www.readbyqxmd.com/read/28948473/buccal-micronucleus-cytome-assay-of-populations-under-chronic-heavy-metal-and-other-metal-exposure-along-the-santiago-river-mexico
#15
B C Gómez-Meda, G M Zúñiga-González, L V Sánchez-Orozco, A L Zamora-Perez, J P Rojas-Ramírez, A D Rocha-Muñoz, A A Sobrevilla-Navarro, M A Arellano-Avelar, A A Guerrero-de León, J S Armendáriz-Borunda, M G Sánchez-Parada
The Santiago River is one of the most contaminated rivers in Mexico, with heavy metal levels above the allowed limits. Scientific evidence indicates that chronic heavy metal exposure leads to cytogenotoxic effects. The aims of this study were to evaluate the genotoxic and cytotoxic effects of such exposure in buccal mucosa cells by micronucleus (MN) assay and to identify other nuclear abnormalities (NAs), such as nuclear buds (NBUDs), binucleated cells (BNs), pyknotic nuclei (PNs), karyorrhexis (KX), karyolysis (KL), and abnormally condensed chromatin (CC)...
September 26, 2017: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/28918018/locked-nucleic-acid-gapmers-and-conjugates-potently-silence-adam33-an-asthma-associated-metalloprotease-with-nuclear-localized-mrna
#16
Hannah M Pendergraff, Pranathi Meda Krishnamurthy, Alexandre J Debacker, Michael P Moazami, Vivek K Sharma, Liisa Niitsoo, Yong Yu, Yen Nee Tan, Hans Michael Haitchi, Jonathan K Watts
Two mechanisms dominate the clinical pipeline for oligonucleotide-based gene silencing, namely, the antisense approach that recruits RNase H to cleave target RNA and the RNAi approach that recruits the RISC complex to cleave target RNA. Multiple chemical designs can be used to elicit each pathway. We compare the silencing of the asthma susceptibility gene ADAM33 in MRC-5 lung fibroblasts using four classes of gene silencing agents, two that use each mechanism: traditional duplex small interfering RNAs (siRNAs), single-stranded small interfering RNAs (ss-siRNAs), locked nucleic acid (LNA) gapmer antisense oligonucleotides (ASOs), and novel hexadecyloxypropyl conjugates of the ASOs...
September 15, 2017: Molecular Therapy. Nucleic Acids
https://www.readbyqxmd.com/read/28913511/accuracy-of-formulae-for-secondary-intraocular-lens-power-calculations-in-pediatric-aphakia
#17
Fouad R Nakhli, Khaled Emarah, Laila Jeddawi
PURPOSE: To compare the accuracy of axial length vergence formulas versus refractive vergence formulas for secondary intraocular lens (IOL) implantation in pediatric aphakia. METHODS: This retrospective comparative study, evaluated 31 eyes of 31 patients aged ≤3.5 years, who had undergone secondary IOL implantation. The median absolute error (MedAE) was compared between axial length vergence formulas (Hoffer Q, Holladay I, SRK II, and SRK/T) and refractive vergence formulas (Lanchulev, Holladay R, Mackool, and Khan) as well as between formulas within the same vergence...
September 2017: Journal of Current Ophthalmology
https://www.readbyqxmd.com/read/28901724/codeine-influences-the-serum-and-urinary-profile-of-endogenous-androgens-but-does-not-interact-with-the-excretion-rate-of-administered-testosterone
#18
M Lehtihet, A Andersson, A Börjesson, J Schulze, A Rane, M Ericsson, L Ekström
Today's doping tests involve longitudinal monitoring of urinary steroids including the testosterone glucuronide and epitestosterone glucuronide ratio (T/E) in an athlete biological passport (ABP). The aim of this study was to investigate the possible influence of short term use of codeine on the urinary excretion of androgen metabolites included in the steroidal module of the passport prior to and after the co-administration with testosterone. The study was designed as an open study with the subjects being their own control...
September 13, 2017: Drug Testing and Analysis
https://www.readbyqxmd.com/read/28898951/biocompatible-hollow-polymeric-particles-produced-by-a-mild-solvent-and-template-free-strategy
#19
Eustolia Rodríguez-Velázquez, Pablo Taboada, Manuel Alatorre-Meda
Macroscopic hollow polymeric particles are attractive materials for various applications such as surgery, food industry, agriculture, etc. However, protocols reporting their synthesis have hitherto made use of organic solvents and/or sacrificial templates, compromising the encapsulation of different bioactive compounds and the process yield. Here, millimeter-size, hollow polymeric particles were synthesized, for the first time, in a solvent- and template free manner onto superhydrophobic surfaces (SHS). The particles were produced upon assembly and double superficial crosslinking of liquid droplets of DNA and methacrylamide chitosan aqueous solutions (CH:MA), leading to liquid-core particles with a hardened hydrogel shell...
August 31, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28844780/5-aminolevulinic-acid-fluorescence-guided-resection-of-malignant-glioma-hong-kong-experience
#20
Danny Tat Ming Chan, Hsieh Yi-Pin Sonia, Wai Sang Poon
BACKGROUND: 5-Aminolevulinic Acid (5-ALA) induced fluorescence is useful in guiding glioma resection. The extent of 5-ALA accumulation is beyond gadolinium contrast enhancement.(1,2) Supratotal resection may be achieved, potentially granting patients with better survival. We present our experience on 5-ALA guided glioma resection in Chinese ethnics. METHOD: Sixteen Patients ingested 5-ALA (Gliolan, Medas Germany) 20 mg/kg·m(2) 4 h before surgery. The tumor resection was guided by fluorescence with neurosurgical microscope...
August 24, 2017: Asian Journal of Surgery
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