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https://www.readbyqxmd.com/read/28918018/locked-nucleic-acid-gapmers-and-conjugates-potently-silence-adam33-an-asthma-associated-metalloprotease-with-nuclear-localized-mrna
#1
Hannah M Pendergraff, Pranathi Meda Krishnamurthy, Alexandre J Debacker, Michael P Moazami, Vivek K Sharma, Liisa Niitsoo, Yong Yu, Yen Nee Tan, Hans Michael Haitchi, Jonathan K Watts
Two mechanisms dominate the clinical pipeline for oligonucleotide-based gene silencing, namely, the antisense approach that recruits RNase H to cleave target RNA and the RNAi approach that recruits the RISC complex to cleave target RNA. Multiple chemical designs can be used to elicit each pathway. We compare the silencing of the asthma susceptibility gene ADAM33 in MRC-5 lung fibroblasts using four classes of gene silencing agents, two that use each mechanism: traditional duplex small interfering RNAs (siRNAs), single-stranded small interfering RNAs (ss-siRNAs), locked nucleic acid (LNA) gapmer antisense oligonucleotides (ASOs), and novel hexadecyloxypropyl conjugates of the ASOs...
September 15, 2017: Molecular Therapy. Nucleic Acids
https://www.readbyqxmd.com/read/28913511/accuracy-of-formulae-for-secondary-intraocular-lens-power-calculations-in-pediatric-aphakia
#2
Fouad R Nakhli, Khaled Emarah, Laila Jeddawi
PURPOSE: To compare the accuracy of axial length vergence formulas versus refractive vergence formulas for secondary intraocular lens (IOL) implantation in pediatric aphakia. METHODS: This retrospective comparative study, evaluated 31 eyes of 31 patients aged ≤3.5 years, who had undergone secondary IOL implantation. The median absolute error (MedAE) was compared between axial length vergence formulas (Hoffer Q, Holladay I, SRK II, and SRK/T) and refractive vergence formulas (Lanchulev, Holladay R, Mackool, and Khan) as well as between formulas within the same vergence...
September 2017: Journal of Current Ophthalmology
https://www.readbyqxmd.com/read/28901724/codeine-influences-the-serum-and-urinary-profile-of-endogenous-androgens-but-does-not-interact-with-the-excretion-rate-of-administered-testosterone
#3
M Lehtihet, A Andersson, A Börjesson, J Schulze, A Rane, M Ericsson, L Ekström
Today's doping tests involve longitudinal monitoring of urinary steroids including the testosterone glucuronide and epitestosterone glucuronide ratio (T/E) in an athlete biological passport (ABP). The aim of this study was to investigate the possible influence of short term use of codeine on the urinary excretion of androgen metabolites included in the steroidal module of the passport prior to and after the co-administration with testosterone. The study was designed as an open study with the subjects being their own control...
September 13, 2017: Drug Testing and Analysis
https://www.readbyqxmd.com/read/28898951/biocompatible-hollow-polymeric-particles-produced-by-a-mild-solvent-and-template-free-strategy
#4
Eustolia Rodríguez-Velázquez, Pablo Taboada, Manuel Alatorre-Meda
Macroscopic hollow polymeric particles are attractive materials for various applications such as surgery, food industry, agriculture, etc. However, protocols reporting their synthesis have hitherto made use of organic solvents and/or sacrificial templates, compromising the encapsulation of different bioactive compounds and the process yield. Here, millimeter-size, hollow polymeric particles were synthesized, for the first time, in a solvent- and template free manner onto superhydrophobic surfaces (SHS). The particles were produced upon assembly and double superficial crosslinking of liquid droplets of DNA and methacrylamide chitosan aqueous solutions (CH:MA), leading to liquid-core particles with a hardened hydrogel shell...
August 31, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28844780/5-aminolevulinic-acid-fluorescence-guided-resection-of-malignant-glioma-hong-kong-experience
#5
Danny Tat Ming Chan, Hsieh Yi-Pin Sonia, Wai Sang Poon
BACKGROUND: 5-Aminolevulinic Acid (5-ALA) induced fluorescence is useful in guiding glioma resection. The extent of 5-ALA accumulation is beyond gadolinium contrast enhancement.(1,2) Supratotal resection may be achieved, potentially granting patients with better survival. We present our experience on 5-ALA guided glioma resection in Chinese ethnics. METHOD: Sixteen Patients ingested 5-ALA (Gliolan, Medas Germany) 20 mg/kg·m(2) 4 h before surgery. The tumor resection was guided by fluorescence with neurosurgical microscope...
August 24, 2017: Asian Journal of Surgery
https://www.readbyqxmd.com/read/28811698/effect-of-tulsi-ocimum-sanctum-linn-supplementation-on-metabolic-parameters-and-liver-enzymes-in-young-overweight-and-obese-subjects
#6
Swayamjeet Satapathy, Namrata Das, Debapriya Bandyopadhyay, Sushil Chandra Mahapatra, Dip Sundar Sahu, Mruthyumjayarao Meda
Ocimum sanctum Linn. (also known as Tulsi) is a sacred Indian plant, the beneficial role of which, in obesity and diabetes is described traditionally. This is a randomized, parallel group, open label pilot study to investigate the effect of O. sanctum on metabolic and biochemical parameters in thirty overweight/obese subjects, divided into two groups A and B. Group A (n = 16) received one 250 mg capsule of Tulsi (O. sanctum) extract twice daily in empty stomach for 8 weeks and group B (n = 14) received no intervention...
July 2017: Indian Journal of Clinical Biochemistry: IJCB
https://www.readbyqxmd.com/read/28797840/nerves-h2o2-and-shh-three-players-in-the-game-of-regeneration
#7
REVIEW
Francesca Meda, Christine Rampon, Edmond Dupont, Carole Gauron, Aurélien Mourton, Isabelle Queguiner, Marion Thauvin, Michel Volovitch, Alain Joliot, Sophie Vriz
The tight control of reactive oxygen species (ROS) levels is required during regeneration. H2O2 in particular assumes clear signalling functions at different steps in this process. Injured nerves induce high levels of H2O2 through the activation of the Hedgehog (Shh) pathway, providing an environment that promotes cell plasticity, progenitor recruitment and blastema formation. In turn, high H2O2 levels contribute to growing axon attraction. Once re-innervation is completed, nerves subsequently downregulate H2O2 levels to their original state...
August 7, 2017: Seminars in Cell & Developmental Biology
https://www.readbyqxmd.com/read/28793255/%C3%AE-e-catenin-is-a-positive-regulator-of-pancreatic-islet-cell-lineage-differentiation
#8
Antonio J Jimenez-Caliani, Rudolf Pillich, Wendy Yang, Giuseppe R Diaferia, Paolo Meda, Laura Crisa, Vincenzo Cirulli
The development and function of epithelia depend on the establishment and maintenance of cell-cell adhesion and intercellular junctions, which operate as mechanosensor hubs for the transduction of biochemical signals regulating cell proliferation, differentiation, survival, and regeneration. Here, we show that αE-catenin, a key component of adherens junctions, functions as a positive regulator of pancreatic islet cell lineage differentiation by repressing the sonic hedgehog pathway (SHH). Thus, deletion of αE-catenin in multipotent pancreatic progenitors resulted in (1) loss of adherens junctions, (2) constitutive activation of SHH, (3) decrease in islet cell lineage differentiation, and (4) accumulation of immature Sox9(+) progenitors...
August 8, 2017: Cell Reports
https://www.readbyqxmd.com/read/28791823/echocardiographic-characteristics-of-pulmonary-arterial-hypertension-in-children-with-horizontally-transmitted-hiv
#9
Anca Meda Georgescu, Cosmin Moldovan, Janos Szederjesi, Dan Georgescu, Leonard Azamfirei
BACKGROUND: The prevalence of primitive pulmonary arterial hypertension (PAH) in patients with human immunodeficiency virus infection (HIV) is estimated at approximately 0.5%, significantly higher than in the general population. OBJECTIVES: This study aimed to assess the echocardiographic modifications in HIV-associated pulmonary arterial hypertension (PAH). MATERIAL AND METHODS: A group of 117 patients, aged under 16, with horizontally transmitted HIV staged according to the U...
May 2017: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/28761746/clinical-value-of-early-detection-of-circulating-tumour-dna-braf-v600mut-in-patients-with-metastatic-melanoma-treated-with-a-braf-inhibitor
#10
Baptiste Louveau, Jörg Tost, Florence Mauger, Aurélie Sadoux, Marie-Pierre Podgorniak, Alexandre How-Kit, Cécile Pages, Jennifer Roux, Laetitia Da Meda, Céleste Lebbe, Samia Mourah
No abstract text is available yet for this article.
2017: ESMO Open
https://www.readbyqxmd.com/read/28749411/advances-in-testing-techniques-for-digital-microfluidic-biochips
#11
REVIEW
Vineeta Shukla, Fawnizu Azmadi Hussin, Nor Hisham Hamid, Noohul Basheer Zain Ali
With the advancement of digital microfluidics technology, applications such as on-chip DNA analysis, point of care diagnosis and automated drug discovery are common nowadays. The use of Digital Microfluidics Biochips (DMFBs) in disease assessment and recognition of target molecules had become popular during the past few years. The reliability of these DMFBs is crucial when they are used in various medical applications. Errors found in these biochips are mainly due to the defects developed during droplet manipulation, chip degradation and inaccuracies in the bio-assay experiments...
July 27, 2017: Sensors
https://www.readbyqxmd.com/read/28741383/adherence-to-mediterranean-diet-and-metabolic-syndrome-in-brca-mutation-carriers
#12
Eleonora Bruno, Siranoush Manoukian, Elisabetta Venturelli, Andreina Oliverio, Francesca Rovera, Giovanna Iula, Daniele Morelli, Bernard Peissel, Jacopo Azzolini, Eliana Roveda, Patrizia Pasanisi
BACKGROUND: Insulin resistance is associated with higher breast cancer (BC) penetrance in BRCA mutation carriers. Metabolic syndrome (MetS), an insulin resistance syndrome, can be reversed by adhering to the Mediterranean diet (MedDiet). In a dietary intervention trial on BRCA mutation carriers, we evaluated adherence to the MedDiet, and the association with the MetS, by analyzing data from the Mediterranean Diet Adherence Screener (MEDAS). METHODS: BRCA mutation carriers, with or without BC, aged 18 to 70 years, were eligible for the trial...
July 1, 2017: Integrative Cancer Therapies
https://www.readbyqxmd.com/read/28737332/-knowledge-attitudes-and-condom-use-skills-among-youth-in-burkina-faso
#13
Clétus Come Yélian Adohinzin, Nicolas Méda, Adrien Marie Gaston Belem, Georges Anicet Ouédraogo, Abdramane Berthé, Issiaka Sombié, Georgette Damienne Avimadjenon, Ibrahima Diallo, Laurence Fond-Harmant
Introduction: Condom use is recognized by the WHO as the only contraceptive that protects against both HIV / AIDS and unwanted pregnancies. But to be effective, condoms must be used consistently and correctly. The objective of this study was to assess young people’s skills in male condom used, to identify the challenges faced by them when using condoms to better guide future interventions.Methods: Based on a two-level sampling representing 94,947 households within Bobo-Dioulasso municipality, 573 youth aged between 15 and 24 were interviewed...
March 6, 2017: Santé Publique: Revue Multidisciplinaire Pour la Recherche et L'action
https://www.readbyqxmd.com/read/28737320/-trends-in-caesarean-section-rates-and-places-of-delivery-in-burkina-faso
#14
Issiaka Sombié, Ziemlé Clément Méda, Gueswendé Blaise Léon Savadogo, Gwladys Sanou, Moussa Dadjoari
Objective: The objective of this study was to evaluate the trends, mortality rates and places of caesarean section by level of care in Burkina Faso.Method: A retrospective study was conducted using data from Burkina Faso Ministry of Health annual health statistics and public hospital reports from 2000 to 2014. Linear regression was used to analyse caesarean section trends and mortality rates in District Hospitals (HD), Regional Hospitals (CHR) and University Hospitals (CHU).Results: From 2000 to 2014, the number of caesarean sections performed in Burkina Faso public hospitals increased almost tenfold from approximately 2,365 to 19,081, corresponding to a growth of the caesarean section rate from 0...
March 6, 2017: Santé Publique: Revue Multidisciplinaire Pour la Recherche et L'action
https://www.readbyqxmd.com/read/28693050/long-term-results-of-fixation-free-incisional-hernia-repair-using-a-tentacle-shaped-implant
#15
Giuseppe Amato, Giorgio Romano, Thorsten Goetze, Luca Gordini, Enrico Erdas, Fabio Medas, Piergiorgio Calò
INTRODUCTION: The fixation and the overlap of the mesh represent an open issue in incisional hernia repair. An exclusively designed prosthesis has been developed to assure a suture-free repair and a broader coverage of the abdominal wall. This study describes the long-term results of incisional hernia procedures carried out positioning a tentacle-shaped implant through a specifically developed surgical technique. MATERIALS AND METHODS: A proprietary symmetrically-shaped flat mesh constituted by a large central body with integrated radiating arms was used to repair incisional hernias in 68 patients...
July 25, 2017: Surgical Technology International
https://www.readbyqxmd.com/read/28692456/focal-necrotizing-myopathy-with-dropped-head-syndrome-induced-by-cobimetinib-in-metastatic-melanoma
#16
Marie-Léa Gauci, Pauline Laly, Leonard-Louis Sarah, Anthony Behin, Jérémy Gottlieb, Isabelle Madelaine-Chambrin, Barouyr Baroudjian, Laetitia Da-Meda, Samia Mourah, Maxime Battistella, Nicole Basset Seguin, Martine Bagot, Cécile Pages, Laetitia Vercellino, Thierry Maisonobe, Céleste Lebbé
Therapeutic advances derived from targeted therapy and immune checkpoint inhibitors can improve melanoma prognosis. Since 2015, cobimetinib has been approved in combination with vemurafenib in the first-line treatment for BRAF-mutated melanoma. For NRAS-mutated melanomas, MEK inhibition seems to be a therapeutic target, and association with checkpoint inhibitor provides a further therapeutic perspective. Infraclinical creatine phosphokinase (CPK) elevation is an MEK inhibitor side effect. We describe a case of focal necrotizing myopathy with 'dropped-head syndrome' induced by cobimetinib, 1 month after its introduction...
July 7, 2017: Melanoma Research
https://www.readbyqxmd.com/read/28687878/suitability-of-dpph-spiking-for-antioxidant-screening-in-natural-products-the-example-of-galloyl-derivatives-from-red-maple-bark-extract
#17
Thibaud R Geoffroy, Naamwin R Meda, Tatjana Stevanovic
To investigate the antioxidant potential in natural products, radical scavenging tests (ABTS, DPPH, ORAC, etc.) are usually considered as the first approach. In addition to the standard colorimetric assays, methods using separation techniques (on-line and pre-column assays) have been developed in the past decades. Based on the peak area (PA) reductions of compounds monitored by HPLC, the pre-column spiking method allows rapid characterisation of natural matrices avoiding laborious isolation steps. However, available information about the significance of the results produced remains scarce...
July 7, 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/28674660/maternal-alcohol-consumption-during-pregnancy-and-child-s-cognitive-performance-at-6-8-years-of-age-in-rural-burkina-faso-an-observational-study
#18
Anselme Simeon Sanou, Abdoulaye Hama Diallo, Penny Holding, Victoria Nankabirwa, Ingunn Marie S Engebretsen, Grace Ndeezi, James K Tumwine, Nicolas Meda, Thorkild Tylleskar, Esperance Kashala-Abotnes
BACKGROUND: In Burkina Faso, it is not uncommon for mothers to drink alcohol, even during pregnancy. We aimed to study the association between maternal alcohol consumption during pregnancy and the child's cognitive performance using the Kaufman Assessment Battery for Children, 2nd edition (KABC-II) and the Children's Category Test Level 1 (CCT-1) in rural Burkina Faso. METHODS: We conducted a follow-up study of a community cluster-randomised Exclusive breastfeeding trial, and re-enrolled the children in rural Burkina Faso...
2017: PeerJ
https://www.readbyqxmd.com/read/28634928/comparison-of-formulas-and-methods-for-high-myopia-patients-requiring-intraocular-lens-powers-less-than-six-diopters
#19
Harry S Geggel
PURPOSE: To determine the best method to minimize postoperative hyperopia and achieve mild myopia in patients requiring low-powered (<6.00 D) MN60MA intraocular lenses (IOLs). METHODS: This retrospective non-comparative case series consists of 32 eyes (20 patients). Postoperative spherical equivalent (SE) refractions were compared using four methods: standard formulas with varying target refractions (Haigis -1.00 D, Hoffer Q -1.75 D, Holladay 1 -1.50 D and SRK/T -1...
June 20, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28634815/autoimmune-diabetes-induced-by-pd-1-inhibitor-retrospective-analysis-and-pathogenesis-a-case-report-and-literature-review
#20
Marie-Léa Gauci, Pauline Laly, Tiphaine Vidal-Trecan, Barouyr Baroudjian, Jérémy Gottlieb, Nika Madjlessi-Ezra, Laetitia Da Meda, Isabelle Madelaine-Chambrin, Martine Bagot, Nicole Basset-Seguin, Cécile Pages, Samia Mourah, Philippe Boudou, Céleste Lebbé, Jean-François Gautier
Anti-PD-1 antibody treatment is approved in advanced melanoma and provides median overall survival over 24 months. The main treatment-related side effects are immune-related adverse events, which include rash, pruritus, vitiligo, thyroiditis, diarrhoea, hepatitis and pneumonitis. We report a case of autoimmune diabetes related to nivolumab treatment. A 73-year-old man was treated in second line with nivolumab at 3 mg/kg every two weeks for metastatic melanoma. At 6 weeks of treatment, he displayed diabetic ketoacidosis...
June 20, 2017: Cancer Immunology, Immunotherapy: CII
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