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https://www.readbyqxmd.com/read/27895016/are-prophylactic-and-therapeutic-target-concentrations-different-the-case-of-lopinavir-ritonavir-or-lamivudine-administered-to-infants-for-the-prevention-of-mother-to-child-hiv-1-transmission-during-breastfeeding
#1
Frantz Foissac, Jörn Blume, Jean-Marc Tréluyer, Thorkild Tylleskär, Chipepo Kankasa, Nicolas Meda, James K Tumwine, Mandisa Singata-Madliki, Kim Harper, Silvia M Illamola, Naïm Bouazza, Nicolas Nagot, Philippe Van de Perre, Stéphane Blanche, Déborah Hirt
The ANRS 12174 trial assessed the efficacy and tolerance of LPV/r versus 3TC prophylaxis administered to breastfed infants, whose HIV-infected mothers were not on ART. In this sub-study, we assessed LPV/r and 3TC pharmacokinetics to evaluate the percentage of infants with therapeutic plasma concentrations and to discuss these data in the context of a prophylactic treatment. Infants from the South African trial site underwent blood sampling for pharmacokinetic study at week 6, 26 and 38 of life. We applied a Bayesian approach to derive the 3TC and LPV pharmacokinetic parameters based on previously published pharmacokinetic models for HIV-infected children...
November 28, 2016: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/27889159/exposure-to-minimally-processed-pear-and-melon-during-shelf-life-could-modify-the-pathogenic-potential-of-listeria-monocytogenes
#2
Pilar Colás-Medà, Inmaculada Viñas, Márcia Oliveira, Marina Anguera, Jose C E Serrano, Maribel Abadias
Survival and virulence of foodborne pathogens can be influenced by environmental factors such as the intrinsic properties of food as well as the extrinsic properties that contribute to food shelf life (e.g., temperature and gas atmosphere). The direct contribution of food matrix characteristics on the survival of L. monocytogenes during fresh-cut fruit shelf life is not very well understood. In addition, the gastrointestinal tract is the primary route of listeriosis infection and penetration of the intestinal epithelial cell barrier is the first step in the infection process...
April 2017: Food Microbiology
https://www.readbyqxmd.com/read/27882840/a-comparison-of-health-care-resource-utilization-and-costs-for-patients-with-allergic-rhinitis-on-single-product-or-free-combination-therapy-of-intranasal-steroids-and-intranasal-antihistamines
#3
Brooke Harrow, Ahmad R Sedaghat, Amanda Caldwell-Tarr, Robert Dufour
BACKGROUND: Allergic rhinitis (AR) is a common condition that can be treated with a number of different therapies. Treatments such as intranasal antihistamines (INAs) and intranasal steroids (INSs) are widely used by AR patients. For some allergy sufferers, a combination of therapies, specifically an INA and an INS, is required to address their symptoms. A new treatment, the formulation of azelastine hydrochloride and fluticasone pro-pionate used as a single spray (MP-AzeFlu), has become available for AR patients who need both types of treatment...
December 2016: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/27870761/disease-activity-score-on-28-joints-and-polypharmacy-are-independent-predictors-for-health-related-quality-of-life-evaluated-by-incavisa-in-patients-with-rheumatoid-arthritis
#4
Linda Mariana González-Gamboa, Ana Karen Barocio-Ramírez, Alberto Daniel Rocha-Muñoz, Fabiola de Santos-Ávila, Rosa M Meda-Lara, Laura González-López, Jorge Iván Gámez-Nava, Eduardo Gómez-Bañuelos, Efrain Chavarria-Avila, Sergio Durán-Barragán, Rosa Elena Navarro-Hernández, Oscar Enrique Pizano-Martínez, Lourdes Nuñez-Atahualpa, Mónica Vázquez-Del Mercado
OBJECTIVE: The aim of this study was to investigate the main factors associated to a diminished health-related quality of life (HRQoL) evaluated by INCAVISA (Health-Related Quality of Life Inventory for Latin American Patients) in patients with rheumatoid arthritis (RA). METHODS: Female, 18 years or older, RA (American College of Rheumatology 1987 criteria and American College of Rheumatology/European League against Rheumatism 2010 criteria) patients who attended the outpatient rheumatology department of the Hospital Civil "Dr...
December 2016: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
https://www.readbyqxmd.com/read/27864449/what-are-the-critical-steps-in-processing-blood-cultures-a-prospective-audit-evaluating-current-practice-of-reporting-blood-cultures-in-a-centralised-laboratory-serving-secondary-care-hospitals
#5
Manjula Meda, James Clayton, Reela Varghese, Jayakeerthi Rangaiah, Clive Grundy, Farnaz Dashti, David Garner, Katherine Groves, Karen Fitzmaurice, E Hutley
AIMS: To assess current procedures of processing positive blood cultures against national standards with an aim to evaluate its clinical impact and to determine the utility of currently available rapid identification and susceptibility tests in processing of blood cultures. METHODS: Blood cultures from three secondary care hospitals, processed at a centralised laboratory, were prospectively audited. Data regarding processing times, communication with prescribers, changes to patient management and mortality within 30 days of a significant blood culture were collected in a preplanned pro forma for a 4-week period...
November 18, 2016: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/27837463/parathyroidectomy-for-primary-hyperparathyroidism-in-the-elderly-experience-of-a-single-endocrine-surgery-center
#6
Pietro Giorgio Calò, Fabio Medas, Giulia Loi, Giuseppe Pisano, Salvatore Sorrenti, Enrico Erdas, Angelo Nicolosi
BACKGROUND: Primary hyperparathyroidism is a common endocrine disease, and its incidence increases with age. AIMS: Our aim was to retrospectively evaluate the impact of age on patient outcomes following parathyroidectomy for primary hyperparathyroidism. METHODS: Two-hundred fifty-six consecutive patients undergoing parathyroidectomy with preoperative diagnosis of primary hyperparathyroidism were divided into three groups according to patient age: group A, ≤64 years; group B, 65-74 years; and group C, ≥75 years...
November 11, 2016: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/27837460/fixation-free-incisional-hernia-repair-in-the-elderly-our-experience-with-a-tentacle-shaped-implant
#7
Giorgio Romano, Pier Giorgio Calò, Enrico Erdas, Fabio Medas, Luca Gordini, Francesco Podda, Giuseppe Amato
BACKGROUND: Incisional hernia in aged patients represents a challenge even for experienced surgeons. Besides increased risk of complications due to comorbidities, mesh fixation and assuring a sufficient mesh overlap of the defect are the main issues in carrying out the repair. AIMS: In order to assure broader coverage of the abdominal wall and a tension- and fixation-free repair, a specifically designed prosthesis was developed for the surgical treatment of incisional hernias...
November 11, 2016: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/27836094/factors-associated-with-fresh-stillbirths-a-hospital-based-matched-case-control-study-in-burkina-faso
#8
Tieba Millogo, Gautier H Ouédraogo, Adama Baguiya, Ivlabèhiré Bertrand Meda, Seni Kouanda, Blaise Sondo
OBJECTIVE: To determine the risk factors for fresh stillbirths in hospitals in Burkina Faso. METHODS: A hospital-based, matched (1:1), case-control study was conducted from July to August 2014 in 50 hospitals across the country. All cases of stillbirth that occurred during this period in the participating facilities were included, and an appropriate control was selected for each case from the same health facility. Cases and controls were matched for gestational age...
November 2016: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/27836093/factors-associated-with-very-early-neonatal-mortality-in-burkina-faso-a-matched-case-control-study
#9
Rémi Kaboré, Ivlabèhiré Bertrand Meda, Jean-Louis Emmanuel Koulidiati, Tiéba Millogo, Seni Kouanda
OBJECTIVE: To identify the risk factors associated with very early neonatal death in Burkina Faso. METHODS: A matched case-control study including newborns born between May 2009 and April 2010. Cases comprised newborns that died within 24hours of birth, whereas controls were those of a similar birth weight to the cases who survived the first 24hours. Potential risk factors related to mothers, neonates, and healthcare provision were assessed from medical records and via interviews...
November 2016: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/27836092/predictors-of-mortality-of-low-birth-weight-newborns-during-the-neonatal-period-a-cohort-study-in-two-health-districts-of-burkina-faso
#10
Abou Coulibaly, Adama Baguiya, Tieba Millogo, Ivlabèhiré Bertrand Meda, Fla Koueta, Seni Kouanda
OBJECTIVE: To determine the neonatal mortality rate among low birth weight infants, and identify the predictors of mortality during the neonatal period in two health districts in Burkina Faso. METHODS: A prospective cohort study of live born babies delivered in health centers that weighed less than 2500 g. Their survival status at the end of the neonatal period was measured and analyzed using multivariate analysis in a Cox proportional hazards model. RESULTS: The study included 341 newborns (146 newborns from Kaya health district and 195 from Dori health district)...
November 2016: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/27836088/indicators-of-availability-use-and-quality-of-emergency-obstetric-and-neonatal-care-in-togo-in-2012
#11
Adja Mariam Ouédraogo, Laeticia Ouédraogo/Nikiema, Ivlabèhiré Bertrand Meda, Kassouta N'Tapi, Seni Kouanda
OBJECTIVE: To assess the availability, utilization, and quality of emergency obstetric and neonatal care (EmONC) in Togo. METHODS: A cross-sectional study of EmONC services in all public and private health facilities in the territory of Togo conducted from July to December, 2012. The generic tools developed by the Averting Maternal Death and Disability program were used as the basic tools for this evaluation. RESULTS: The survey involved 1019 health facilities including 864 potential EmONC facilities that constituted the final sample...
November 2016: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/27836085/rate-of-and-factors-associated-with-indications-for-cesarean-deliveries-results-of-a-national-review-in-burkina-faso
#12
Ivlabèhiré Bertrand Meda, Tieba Millogo, Adama Baguiya, Laeticia Ouédraogo/Nikiema, Abou Coulibaly, Seni Kouanda
OBJECTIVE: To determine the prevalence of cesarean deliveries in Burkina Faso, analyze the indications for them and the outcomes, and identify factors associated with non-absolute maternal indications for the procedure, as opposed to major obstetric interventions performed to save a woman's life. METHODS: In a cross-sectional study, we selected and analyzed cesarean deliveries among those most recently performed between May 2009 and April 2010 in all facilities in Burkina Faso...
November 2016: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/27836083/home-births-in-the-context-of-free-health-care-the-case-of-kaya-health-district-in-burkina-faso
#13
Seni Kouanda, Aristide Bado, Ivlabèhiré Bertrand Meda, Gisèle S Yameogo, Abou Coulibaly, Slim Haddad
OBJECTIVE: To identify the factors associated with home births in the Kaya health district in Burkina Faso, where child delivery was free of charge between 2007 and 2011. METHODS: Both qualitative and quantitative data were collected from the Kaya Health and Demographic Surveillance System (Kaya HDSS) among women who delivered at home or in a health facility between January 2008 and December 2010. Multilevel logistic regression was applied to quantitative data, while the qualitative data were analyzed thematically based on emerging themes, subthemes, and patterns across group and individual cases...
November 2016: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/27836079/availability-and-utilization-of-obstetric-and-newborn-care-in-guinea-a-national-needs-assessment
#14
Adama Baguiya, Ivlabèhiré Bertrand Meda, Tieba Millogo, Mamadou Kourouma, Halima Mouniri, Seni Kouanda
OBJECTIVE: To assess the availability and utilization of emergency obstetric and neonatal care (EmONC) in Guinea given the high maternal and neonatal mortality rates. METHODS: We used the Guinea 2012 needs assessment data collected via a national cross-sectional census of health facilities conducted from September to October 2012. All public, private, and faith-based health facilities that performed at least one delivery during the period of the study were included...
November 2016: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/27817844/brain-structure-biomarkers-in-the-psychosis-biotypes-findings-from-the-bipolar-schizophrenia-network-for-intermediate-phenotypes
#15
Elena I Ivleva, Brett A Clementz, Anthony M Dutcher, Sara J M Arnold, Haekyung Jeon-Slaughter, Sina Aslan, Bradley Witte, Gaurav Poudyal, Hanzhang Lu, Shashwath A Meda, Godfrey D Pearlson, John A Sweeney, Matcheri S Keshavan, Carol A Tamminga
BACKGROUND: The current definitions of psychotic illness lack biological validity, motivating alternative biomarker-driven disease entities. Building on experimental constructs-Biotypes-that were previously developed from cognitive and neurophysiologic measures, we contrast brain anatomy characteristics across Biotypes alongside conventional diagnoses, examining gray matter density (GMD) as an independent validator for the Biotypes. METHODS: Whole brain GMD measures were examined in probands, their relatives, and healthy subjects organized by Biotype and then by DSM-IV-TR diagnosis (n = 1409) using voxel-based morphometry with subsequent subject-level regional characterization and distribution analyses...
August 31, 2016: Biological Psychiatry
https://www.readbyqxmd.com/read/27814962/neural-complexity-as-a-potential-translational-biomarker-for-psychosis
#16
Brandon Hager, Albert C Yang, Roscoe Brady, Shashwath Meda, Brett Clementz, Godfrey D Pearlson, John A Sweeney, Carol Tamminga, Matcheri Keshavan
BACKGROUND: The adaptability of the human brain to the constantly changing environment is reduced in patients with psychotic disorders, leading to impaired cognitive functions. Brain signal complexity, which may reflect adaptability, can be readily quantified via resting-state functional magnetic resonance imaging (fMRI) signals. We hypothesized that resting-state brain signal complexity is altered in psychotic disorders, and is correlated with cognitive impairment. METHODS: We assessed 156 healthy controls (HC) and 330 probands, including 125 patients with psychotic bipolar disorder (BP), 107 patients with schizophrenia (SZ), 98 patients with schizoaffective disorder (SAD) and 230 of their unaffected first-degree relatives (76 BPR, 79 SADR, and 75 SZR) from four sites of the Bipolar-Schizophrenia Network on Intermediate Phenotypes (B-SNIP) consortium...
October 26, 2016: Journal of Affective Disorders
https://www.readbyqxmd.com/read/27813092/the-impact-of-a-cold-chain-break-on-the-survival-of-salmonella-enterica-and-listeria-monocytogenes-on-minimally-processed-conference-pears-during-their-shelf-life
#17
Pilar Colás-Medà, Inmaculada Viñas, Isabel Alegre, Maribel Abadias
BACKGROUND: In recent years, improved detection methods and increased fresh-cut processing of produce have led to an increased number of outbreaks associated with fresh fruits and vegetables. During fruit and vegetable processing, natural protective barriers are removed and tissues are cut, causing nutrient rich exudates and providing attachment sites for microbes. Consequently, fresh-cut produce is more susceptible to microbial proliferation than whole produce. RESULTS: The aim of this study was to examine the impact of storage temperature on the growth and survival of Listeria monocytogenes and Salmonella enterica on a fresh-cut 'Conference' pear over an eight day storage period...
November 4, 2016: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/27792890/micronucleated-erythrocytes-in-newborns-rats-exposed-to-three-different-types-of-ultraviolet-a-uva-lamps-from-commonly-uses-devices
#18
Guillermo M Zúñiga-González, Belinda C Gómez-Meda, Ana L Zamora-Perez, María A Martínez-González, Miguel A Bautista-Bejarano, Sebastián Patiño-Valenzuela, Juan Armendáriz-Borunda, Blanca P Lazalde-Ramos, María G Sánchez-Parada, Martha P Gallegos-Arreola
Exposure to ultraviolet-A (UVA) light can accidentally cause adverse effects in the skin and eyes. UVA induces DNA damage directly by creating pyrimidine dimers or by the formation of reactive oxygen species that can indirectly affect DNA integrity. UVA radiation is emitted by lamps from everyday devices. In adult rats, micronucleated erythrocytes (MNE) are removed from the circulation by the spleen. However, in newborn rats, MNE have been observed in peripheral blood erythrocytes. The objective of this study was to use micronucleus tests to evaluate the DNA damage caused in newborn rats exposed to UVA light from three different types of UVA lamps obtained from commonly used devices: counterfeit detectors, insecticide devices, and equipment used to harden resins for artificial nails...
October 21, 2016: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/27789186/novel-gene-brain-structure-relationships-in-psychotic-disorder-revealed-using-parallel-independent-component-analyses
#19
Neeraj Tandon, Pranav Nanda, Jaya L Padmanabhan, Ian T Mathew, Shaun M Eack, Balaji Narayanan, Shashwath A Meda, Sarah E Bergen, Gualbert Ruaño, Andreas Windemuth, Mohan Kocherla, Tracey L Petryshen, Brett Clementz, John Sweeney, Carol Tamminga, Godfrey Pearlson, Matcheri S Keshavan
BACKGROUND: Schizophrenia, schizoaffective disorder, and psychotic bipolar disorder overlap with regard to symptoms, structural and functional brain abnormalities, and genetic risk factors. Neurobiological pathways connecting genes to clinical phenotypes across the spectrum from schizophrenia to psychotic bipolar disorder remain largely unknown. METHODS: We examined the relationship between structural brain changes and risk alleles across the psychosis spectrum in the multi-site Bipolar-Schizophrenia Network for Intermediate Phenotypes (B-SNIP) cohort...
October 24, 2016: Schizophrenia Research
https://www.readbyqxmd.com/read/27780677/total-thyroidectomy-alone-versus-ipsilateral-versus-bilateral-prophylactic-central-neck-dissection-in-clinically-node-negative-differentiated-thyroid-carcinoma-a-retrospective-multicenter-study
#20
P G Calò, G Conzo, M Raffaelli, F Medas, C Gambardella, C De Crea, L Gordini, R Patrone, L Sessa, E Erdas, E Tartaglia, C P Lombardi
BACKGROUND: Central neck dissection (CND) remains controversial in clinically node-negative differentiated thyroid carcinoma (DTC) patients. The aim of this multicenter retrospective study was to determine the rate of central neck metastases, the morbidity and the rate of recurrence in patients treated with total thyroidectomy (TT) alone or in combination with bilateral or ipsilateral CND. METHODS: The clinical records of 163 clinically node-negative consecutive DTC patients treated between January 2008 and December 2010 in three endocrine surgery referral units were retrospectively evaluated...
October 13, 2016: European Journal of Surgical Oncology
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