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https://www.readbyqxmd.com/read/28034414/the-effect-of-short-message-system-sms-reminder-on-adherence-to-a-healthy-diet-medication-and-cessation-of-smoking-among-adult-patients-with-cardiovascular-diseases
#1
Laila M Akhu-Zaheya, Wa'ed Y Shiyab
BACKGROUND: Cardiovascular Disease is the leading cause of death worldwide. Non-adherence to a recommended regimen among patients with Cardiovascular Diseases represents a significant problem which could lead to an increase in Cardiovascular Diseases. PURPOSE: This study aimed to assess the effects of Short Message System (SMS) reminders on adherence to a healthy diet, medication, and cessation of smoking among adult patients with Cardiovascular Diseases. METHODS: Randomized controlled trial design with three groups was used for this study...
February 2017: International Journal of Medical Informatics
https://www.readbyqxmd.com/read/28018917/micronucleated-erythrocytes-in-peripheral-blood-from-neonate-rats-exposed-by-breastfeeding-to-cyclophosphamide-colchicine-or-cytosine-arabinoside
#2
Belinda C Gómez-Meda, Luis R Bañales-Martínez, Ana L Zamora-Perez, María de Lourdes Lemus-Varela, Xóchitl Trujillo, María G Sánchez-Parada, Blanca M Torres-Mendoza, Juan Armendáriz-Borunda, Guillermo M Zúñiga-González
Genotoxic exposure to chemical substances is common, and nursing mothers could transmit harmful substances or their metabolites to their offspring through breast milk. We explored the possibility of determining genotoxic effects in the erythrocytes of breastfeeding rat pups whose mothers received a genotoxic compound while nursing. Ten groups of female rats and five pups per dam were studied. The control group received sterile water, and the experimental groups received one of three different doses of cyclophosphamide, colchicine, or cytosine-arabinoside...
2016: BioMed Research International
https://www.readbyqxmd.com/read/28017910/nutrition-knowledge-and-mediterranean-diet-adherence-in-the-southeast-united-states-validation-of-a-field-based-survey-instrument
#3
Mary Rose Bottcher, Patricia Z Marincic, Katie L Nahay, Brittany E Baerlocher, Amy W Willis, Jieun Park, Philippe Gaillard, Michael W Greene
The Mediterranean diet (MD) can reduce chronic disease risk and is a recommended diet for prevention and management of diabetes. Adherence to the MD in the southeast United States where obesity and diabetes are highly prevalent is unknown. The purpose of the present study was to: 1) construct a survey instrument relevant to the general population integrating both MD related nutrition knowledge and adherence questions from previously validated instruments, and 2) assess MD related nutrition knowledge and adherence in a sample population in the southest United States...
December 23, 2016: Appetite
https://www.readbyqxmd.com/read/28006000/glibenclamide-prevents-diabetes-in-nod-mice
#4
Smaragda Lamprianou, Conny Gysemans, Joanna Bou Saab, Helena Pontes, Chantal Mathieu, Paolo Meda
Previous work has revealed that Cx36, the sole connexin expressed in the insulin-producing beta cells, enhances the secretion of insulin, and promotes the resistance of beta cells against pro-inflammatory cytokines. In parallel, the anti-diabetic sulphonylurea glibenclamide was shown to promote the assembly and function of Cx36 channels. Here, we assessed whether glibenclamide could protect the insulin-producing cells against conditions mimicking those expected at the onset of type 1 diabetes. We found that the drug 1) protected in vitro the mouse MIN6 cells from the apoptosis and loss of Cx36, which are induced by Th1 cytokines; 2) prevented the development of hyperglycemia as well as the loss of beta cells and Cx36, which rapidly develop with aging in untreated NOD mice; 3) modified the proportion of effector CD4+ and CD8+ T cells in pancreatic draining lymph nodes...
2016: PloS One
https://www.readbyqxmd.com/read/28002526/micro-ct-and-optical-microscopy-imagistic-investigations-of-root-canal-morphology
#5
Emanuela Lidia Crăciunescu, Marius Boariu, Ciprian IoniŢă, Daniela Maria Pop, Cosmin Sinescu, Mihai Romînu, Meda Lavinia NegruŢiu
Protecting the root's internal morphology is the first key toward the success of the endodontic treatment. Due to the vast diversity of endodontic space, it is difficult to visualize and to establish the shape and limits of the root canal, especially the morphology of apical area and lateral root canals. Optical microscopy is a classical imagistic investigation method, widely used along classical methods like radiographs that also offer limited information about root morphology and extension of decay. Micro-computed tomography (micro-CT), a modern imagistic investigation method can provide detailed three-dimensional reconstructions of root canal...
2016: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
https://www.readbyqxmd.com/read/28002510/caspase-3-expression-and-plasma-level-of-fas-ligand-as-apoptosis-biomarkers-in-inflammatory-endotoxemic-lung-injury
#6
Raluca Ştefania Fodor, Anca Meda Georgescu, Bianca Liana Grigorescu, Adrian Dan Cioc, Mihaly Veres, Ovidiu Simion Cotoi, Pal Fodor, Sanda Maria Copotoiu, Leonard Azamfirei
OBJECTIVE: The objective of this study is to evaluate if the immunohistochemical expression of a pulmonary apoptosis marker and plasma level of Fas ligand (FasL) correlates with the dose- and time-dependent severity of lung injury, induced by the administration of lipo-polysaccharide (LPS) in an endotoxemic rat model. MATERIALS AND METHODS: Our study included 30 male Wistar rats, randomly divided into three groups: one control group (n=6) and two experimental groups (n=12÷group), in whom we induced endotoxemia by intraperitoneal injection of progressively increasing doses of LPS (5, 10 mg÷kg)...
2016: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
https://www.readbyqxmd.com/read/27943298/a-physiologically-based-pharmacokinetic-model-for-chickens-exposed-to-feed-supplemented-with-monensin-during-their-lifetime
#7
J Henri, R Carrez, B Méda, M Laurentie, P Sanders
We developed a flow-limited physiologically based pharmacokinetic model for residues of monensin in chickens and evaluated its predictive ability by comparing it with an external data set describing concentration decays after the end of treatment. One advantage of this model is that the values for most parameters (34 of 38) were taken directly from the literature or from field data (for growth and feed intake). Our model included growth (changes in body weight) to describe exposure throughout the life of the chicken...
December 12, 2016: Journal of Veterinary Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/27938530/surgical-management-of-gynecomastia-experience-of-a-general-surgery-center
#8
A Longheu, F Medas, F Corrias, S Farris, A Tatti, G Pisano, E Erdas, P G Calò
AIM: Gynecomastia is a common finding in male population of all ages. The aim of our study was to present our experience and goals in surgical treatment of gynecomastia. PATIENTS AND METHODS: Clinical records of patients affected by gynecomastia referred to our Department of Surgery between September 2008 and January 2015 were analyzed. 50 patients were included in this study. RESULTS: Gynecomastia was monolateral in 12 patients (24%) and bilateral in 38 (76%); idiopathic in 41 patients (82%) and secondary in 9 (18%)...
July 2016: Il Giornale di Chirurgia
https://www.readbyqxmd.com/read/27922171/connexins-and-pannexins-from-biology-towards-clinical-targets
#9
Paolo Meda, Jacques-Antoine Haefliger
Efficient cell communication is a prerequisite for the coordinated function of tissues and organs. In vertebrates, this communication is mediated by a variety of mechanisms, including the exchange of molecules between cells, and between cells and the extracellular medium, via membrane channels made of connexin and pannexin proteins. These channels are a necessary component of all human tissues. Here, we review the biological essentials of the connexin and pannexin families, and the roles of these proteins in the function of cells which are central to major human diseases...
2016: Swiss Medical Weekly
https://www.readbyqxmd.com/read/27908286/cost-analysis-of-large-scale-implementation-of-the-helping-babies-breathe-newborn-resuscitation-training-program-in-tanzania
#10
Sumona Chaudhury, Lauren Arlington, Shelby Brenan, Allan Kaijunga Kairuki, Amunga Robson Meda, Kahabi G Isangula, Victor Mponzi, Dunstan Bishanga, Erica Thomas, Georgina Msemo, Mary Azayo, Alice Molinier, Brett D Nelson
BACKGROUND: Helping Babies Breathe (HBB) has become the gold standard globally for training birth-attendants in neonatal resuscitation in low-resource settings in efforts to reduce early newborn asphyxia and mortality. The purpose of this study was to do a first-ever activity-based cost-analysis of at-scale HBB program implementation and initial follow-up in a large region of Tanzania and evaluate costs of national scale-up as one component of a multi-method external evaluation of the implementation of HBB at scale in Tanzania...
December 1, 2016: BMC Health Services Research
https://www.readbyqxmd.com/read/27895016/are-prophylactic-and-therapeutic-target-concentrations-different-the-case-of-lopinavir-ritonavir-or-lamivudine-administered-to-infants-for-the-prevention-of-mother-to-child-hiv-1-transmission-during-breastfeeding
#11
Frantz Foissac, Jörn Blume, Jean-Marc Tréluyer, Thorkild Tylleskär, Chipepo Kankasa, Nicolas Meda, James K Tumwine, Mandisa Singata-Madliki, Kim Harper, Silvia M Illamola, Naïm Bouazza, Nicolas Nagot, Philippe Van de Perre, Stéphane Blanche, Déborah Hirt
The ANRS 12174 trial assessed the efficacy and tolerance of LPV/r versus 3TC prophylaxis administered to breastfed infants, whose HIV-infected mothers were not on ART. In this sub-study, we assessed LPV/r and 3TC pharmacokinetics to evaluate the percentage of infants with therapeutic plasma concentrations and to discuss these data in the context of a prophylactic treatment. Infants from the South African trial site underwent blood sampling for pharmacokinetic study at week 6, 26 and 38 of life. We applied a Bayesian approach to derive the 3TC and LPV pharmacokinetic parameters based on previously published pharmacokinetic models for HIV-infected children...
November 28, 2016: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/27889159/exposure-to-minimally-processed-pear-and-melon-during-shelf-life-could-modify-the-pathogenic-potential-of-listeria-monocytogenes
#12
Pilar Colás-Medà, Inmaculada Viñas, Márcia Oliveira, Marina Anguera, Jose C E Serrano, Maribel Abadias
Survival and virulence of foodborne pathogens can be influenced by environmental factors such as the intrinsic properties of food as well as the extrinsic properties that contribute to food shelf life (e.g., temperature and gas atmosphere). The direct contribution of food matrix characteristics on the survival of L. monocytogenes during fresh-cut fruit shelf life is not very well understood. In addition, the gastrointestinal tract is the primary route of listeriosis infection and penetration of the intestinal epithelial cell barrier is the first step in the infection process...
April 2017: Food Microbiology
https://www.readbyqxmd.com/read/27882840/a-comparison-of-health-care-resource-utilization-and-costs-for-patients-with-allergic-rhinitis-on-single-product-or-free-combination-therapy-of-intranasal-steroids-and-intranasal-antihistamines
#13
Brooke Harrow, Ahmad R Sedaghat, Amanda Caldwell-Tarr, Robert Dufour
BACKGROUND: Allergic rhinitis (AR) is a common condition that can be treated with a number of different therapies. Treatments such as intranasal antihistamines (INAs) and intranasal steroids (INSs) are widely used by AR patients. For some allergy sufferers, a combination of therapies, specifically an INA and an INS, is required to address their symptoms. A new treatment, the formulation of azelastine hydrochloride and fluticasone pro-pionate used as a single spray (MP-AzeFlu), has become available for AR patients who need both types of treatment...
December 2016: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/27870761/disease-activity-score-on-28-joints-and-polypharmacy-are-independent-predictors-for-health-related-quality-of-life-evaluated-by-incavisa-in-patients-with-rheumatoid-arthritis
#14
Linda Mariana González-Gamboa, Ana Karen Barocio-Ramírez, Alberto Daniel Rocha-Muñoz, Fabiola de Santos-Ávila, Rosa M Meda-Lara, Laura González-López, Jorge Iván Gámez-Nava, Eduardo Gómez-Bañuelos, Efrain Chavarria-Avila, Sergio Durán-Barragán, Rosa Elena Navarro-Hernández, Oscar Enrique Pizano-Martínez, Lourdes Nuñez-Atahualpa, Mónica Vázquez-Del Mercado
OBJECTIVE: The aim of this study was to investigate the main factors associated to a diminished health-related quality of life (HRQoL) evaluated by INCAVISA (Health-Related Quality of Life Inventory for Latin American Patients) in patients with rheumatoid arthritis (RA). METHODS: Female, 18 years or older, RA (American College of Rheumatology 1987 criteria and American College of Rheumatology/European League against Rheumatism 2010 criteria) patients who attended the outpatient rheumatology department of the Hospital Civil "Dr...
December 2016: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
https://www.readbyqxmd.com/read/27864449/what-are-the-critical-steps-in-processing-blood-cultures-a-prospective-audit-evaluating-current-practice-of-reporting-blood-cultures-in-a-centralised-laboratory-serving-secondary-care-hospitals
#15
Manjula Meda, James Clayton, Reela Varghese, Jayakeerthi Rangaiah, Clive Grundy, Farnaz Dashti, David Garner, Katherine Groves, Karen Fitzmaurice, E Hutley
AIMS: To assess current procedures of processing positive blood cultures against national standards with an aim to evaluate its clinical impact and to determine the utility of currently available rapid identification and susceptibility tests in processing of blood cultures. METHODS: Blood cultures from three secondary care hospitals, processed at a centralised laboratory, were prospectively audited. Data regarding processing times, communication with prescribers, changes to patient management and mortality within 30 days of a significant blood culture were collected in a preplanned pro forma for a 4-week period...
November 18, 2016: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/27837463/parathyroidectomy-for-primary-hyperparathyroidism-in-the-elderly-experience-of-a-single-endocrine-surgery-center
#16
Pietro Giorgio Calò, Fabio Medas, Giulia Loi, Giuseppe Pisano, Salvatore Sorrenti, Enrico Erdas, Angelo Nicolosi
BACKGROUND: Primary hyperparathyroidism is a common endocrine disease, and its incidence increases with age. AIMS: Our aim was to retrospectively evaluate the impact of age on patient outcomes following parathyroidectomy for primary hyperparathyroidism. METHODS: Two-hundred fifty-six consecutive patients undergoing parathyroidectomy with preoperative diagnosis of primary hyperparathyroidism were divided into three groups according to patient age: group A, ≤64 years; group B, 65-74 years; and group C, ≥75 years...
November 11, 2016: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/27837460/fixation-free-incisional-hernia-repair-in-the-elderly-our-experience-with-a-tentacle-shaped-implant
#17
Giorgio Romano, Pier Giorgio Calò, Enrico Erdas, Fabio Medas, Luca Gordini, Francesco Podda, Giuseppe Amato
BACKGROUND: Incisional hernia in aged patients represents a challenge even for experienced surgeons. Besides increased risk of complications due to comorbidities, mesh fixation and assuring a sufficient mesh overlap of the defect are the main issues in carrying out the repair. AIMS: In order to assure broader coverage of the abdominal wall and a tension- and fixation-free repair, a specifically designed prosthesis was developed for the surgical treatment of incisional hernias...
November 11, 2016: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/27836094/factors-associated-with-fresh-stillbirths-a-hospital-based-matched-case-control-study-in-burkina-faso
#18
Tieba Millogo, Gautier H Ouédraogo, Adama Baguiya, Ivlabèhiré Bertrand Meda, Seni Kouanda, Blaise Sondo
OBJECTIVE: To determine the risk factors for fresh stillbirths in hospitals in Burkina Faso. METHODS: A hospital-based, matched (1:1), case-control study was conducted from July to August 2014 in 50 hospitals across the country. All cases of stillbirth that occurred during this period in the participating facilities were included, and an appropriate control was selected for each case from the same health facility. Cases and controls were matched for gestational age...
November 2016: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/27836093/factors-associated-with-very-early-neonatal-mortality-in-burkina-faso-a-matched-case-control-study
#19
Rémi Kaboré, Ivlabèhiré Bertrand Meda, Jean-Louis Emmanuel Koulidiati, Tiéba Millogo, Seni Kouanda
OBJECTIVE: To identify the risk factors associated with very early neonatal death in Burkina Faso. METHODS: A matched case-control study including newborns born between May 2009 and April 2010. Cases comprised newborns that died within 24hours of birth, whereas controls were those of a similar birth weight to the cases who survived the first 24hours. Potential risk factors related to mothers, neonates, and healthcare provision were assessed from medical records and via interviews...
November 2016: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/27836092/predictors-of-mortality-of-low-birth-weight-newborns-during-the-neonatal-period-a-cohort-study-in-two-health-districts-of-burkina-faso
#20
Abou Coulibaly, Adama Baguiya, Tieba Millogo, Ivlabèhiré Bertrand Meda, Fla Koueta, Seni Kouanda
OBJECTIVE: To determine the neonatal mortality rate among low birth weight infants, and identify the predictors of mortality during the neonatal period in two health districts in Burkina Faso. METHODS: A prospective cohort study of live born babies delivered in health centers that weighed less than 2500 g. Their survival status at the end of the neonatal period was measured and analyzed using multivariate analysis in a Cox proportional hazards model. RESULTS: The study included 341 newborns (146 newborns from Kaya health district and 195 from Dori health district)...
November 2016: International Journal of Gynaecology and Obstetrics
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