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Carlos Lahoz, Elisa Castillo, Jose M Mostaza, Olaya de Dios, Miguel A Salinero-Fort, Teresa González-Alegre, Francisca García-Iglesias, Eva Estirado, Fernando Laguna, Vanesa Sanchez, Concesa Sabín, Silvia López, Victor Cornejo, Carmen de Burgos, Carmen Garcés
Background: Adherence to a Mediterranean diet seems to be inversely associated with C-reactive protein (CRP) concentration. A 14-point Mediterranean Diet Adherence Screener (MEDAS) has been developed to assess dietary compliance. Objective: The aim of this study was to assess whether each of the MEDAS questions as well as their final score were associated with the levels of CRP in general Spanish population. METHODS: Cross-sectional analysis of 1411 subjects (mean age 61 years, 43.0% males) randomly selected from the general population...
March 20, 2018: Nutrients
G L Canu, J S Bulla, M L Lai, F Medas, G Baghino, E Erdas, S Mariotti, P G Calò
Primary thyroid leiomyosarcoma (LMS) is an extremely rare tumor. We report a case of a 47-year-old male with a rapidly growing neck mass and disfagia. Preoperative investigations were diagnostic of anaplastic carcinoma. Total thyroidectomy with partial esophagectomy and dissection of right infrahyoid muscles was performed. Through histolological and immunohistochemical evaluations a primary thyroid high-grade LMS was diagnosed. At 2 months of follow-up a local recurrence was detected and consequently the patient was submitted to chemotherapy with partial response...
January 2018: Il Giornale di Chirurgia
Meda E Pavkov, Jessica L Harding, Nilka R Burrows
Acute kidney injury is a sudden decrease in kidney function with or without kidney damage, occurring over a few hours or days. Diabetes, hypertension, and advanced age are primary risk factors for acute kidney injury. It is increasingly recognized as an in-hospital complication of sepsis, heart conditions, and surgery (1,2). Its most severe stage requires treatment with dialysis. Acute kidney injury is also associated with higher likelihood of long-term care, incidence of chronic kidney disease and hospital mortality, and health care costs (1,2)...
March 16, 2018: MMWR. Morbidity and Mortality Weekly Report
Simona Bertoli, Alberto Battezzati, Alessandra Petruzzi, Alessandro Leone, Ramona De Amicis, Elena Tramacere, Maddalena Meda, Andrea Foppiani, Antonio Silvani, Elena Lamperti
Nutritional status in adults with high-grade gliomas (HGGs) has been poorly investigated. We studied anthropometrics and fat mass (FM), fat free mass (FFM), and body water in HGGs patients also in relation to disease-related variables. Fifty-one patients (17 III and 34 IV-grade) and fifty-one control group (CG) matched for sex, age, and BMI were enrolled. Neurological scales, anthropometry, bioimpedance, and blood sampling were performed and analyzed according to grade, lesion location, extent of resection, phase of treatment, current steroids and antiepileptic therapy, and age of patient...
March 14, 2018: Nutrition and Cancer
Adriana Cambón, Eva Villar-Alvarez, Manuel Alatorre-Meda, Alberto Pardo, Baltazar Hiram, Silvia Barbosa, Pablo Taboada, Víctor Mosquera
The complexation process and underlying mechanisms that rule the interaction of DNA with the cationic block copolymer Tetronic T901 to form polyplexes and their potential transfection efficiency have been studied under different solution conditions. We noted that T901 favors the formation of self-assembled structures with partially condensed DNA at smaller polymer concentrations than other Pluronic™/Tetronic™-type copolymers previously analysed. The observed polyplexes display sizes from the nano- to the micro- range as derived from DLS, electronic and optical microscopies...
February 17, 2018: Journal of Colloid and Interface Science
James K Tumwine, Victoria Nankabirwa, Hama Abdoulaye Diallo, Ingunn Marie Stadskleiv Engebretsen, Grace Ndeezi, Paul Bangirana, Anselme Simeon Sanou, Espérance Kashala-Abotnes, Michael Boivin, Bruno Giordani, Irene Bircow Elgen, Penny Holding, Angelina Kakooza-Mwesige, Vilde Skylstad, Joyce Nalugya, Thorkild Tylleskar, Nicolas Meda
BACKGROUND: The beneficial effects from exclusive breastfeeding (EBF) have been widely acknowledged. We assessed the effect of exclusive breastfeeding promotion by peer counsellors in Uganda and Burkina Faso, on cognitive abilities, social emotional development, school performance and linear growth among 5-8 years old children. METHODS: Children in the PROMISE EBF trial (2006-2008) were re-enrolled in the follow-up PROMISE Saving Brains (SB) study (2013-2015). Caretaker interviews captured sociodemographic characteristics and social emotional development using the parent version of the Strengths and Difficulties Questionnaire (SDQ)...
2018: PloS One
Jodi L Lukkes, Shirisha Meda, Kevin J Norman, Susan L Andersen
Early life adversity increases depressive behavior that emerges during adolescence. Sensitive periods have been associated with fewer GABAergic interneurons, especially parvalbumin (PV), brain derived growth factor, and its receptor, TrkB. Here, maternal separation (MS) and social isolation (ISO) were used to establish a sensitive period for anhedonic depression using the learned helplessness (LH) paradigm. Female Sprague-Dawley rat pups underwent MS for 4-h/day or received typical care (CON) between postnatal days 2-20; for the ISO condition, separate cohorts were individually housed between days 20-40 or served as controls (CON2)...
February 13, 2018: Journal of Psychiatric Research
Akiko Kunita, Vanessa Baeriswyl, Claudia Meda, Erik Cabuy, Kimiko Takeshita, Enrico Giraudo, Andreas Wicki, Masashi Fukayama, Gerhard Christofori
Tumor invasion is a critical first step in the organismic dissemination of cancer cells and the formation of metastasis in distant organs, the most important prognostic factor and the actual cause of death in most of the cancer patients. We report here that the cell surface protein podoplanin (PDPN), a potent inducer of cancer cell invasion, is conspicuously expressed by the invasive front of squamous cell carcinomas (SCC) of the cervix in patients and in the transgenic HPV/E2 mouse model of cervical cancer...
February 16, 2018: American Journal of Pathology
Mingue Kim, Youngsub Eom, Hwa Lee, Young-Woo Suh, Jong Suk Song, Hyo Myung Kim
Purpose: To evaluate the accuracy of IOL power calculation using adjusted corneal power according to the posterior/anterior corneal curvature radii ratio. Methods: Nine hundred twenty-eight eyes from 928 reference subjects and 158 eyes from 158 cataract patients who underwent phacoemulsification surgery were enrolled. Adjusted corneal power of cataract patients was calculated using the fictitious refractive index that was obtained from the geometric mean posterior/anterior corneal curvature radii ratio of reference subjects and adjusted anterior and predicted posterior corneal curvature radii from conventional keratometry (K) using the posterior/anterior corneal curvature radii ratio...
February 1, 2018: Investigative Ophthalmology & Visual Science
Beth A Taylor, Alecia D Dager, Gregory A Panza, Amanda L Zaleski, Shashwath Meda, Gregory Book, Michael C Stevens, Sarah Tartar, C Michael White, Donna M Polk, Godfrey D Pearlson, Paul D Thompson
BACKGROUND: Functional magnetic resonance imaging (fMRI) has not been used to assess the effects of statins on the brain. We assessed the effect of statins on cognition using standard neuropsychological assessments and brain neural activation with fMRI on two tasks. METHODS: Healthy statin-naïve men and women (48±15 years) were randomized to 80 mg/day atorvastatin (n=66; 27 men) or placebo (n=84; 48 men) for 6 months. Participants completed cognitive testing while on study drug and 2 months after treatment cessation using alternative test and task versions...
March 2018: American Heart Journal
Iulia Ioana Roman, Teodora Mocan, Meda-Sandra Orasan, Elena Mihaela Jianu, Carmen-Angela Sfrangeu, Remus-Ioan Orasan
Background and aim: Psoriasis vulgaris, a chronic inflammatory skin disease, requires a long term medication, in order to avoid relapsing episodes. TNF-alpha, one of the targeted molecule in psoriasis therapy, seems to be also involved in thyroid disorders etiopathogenesis. The aim of this study was to evaluate the relationship between anti TNF-alpha therapy and thyroid parameters: serum level of triiodothyronine (T3), free thyroxine (FT4), thyroid-stimulating hormone (TSH) and antithyroidperoxidase antibody (AbTPO) in psoriasis treated population...
2018: Clujul Medical (1957)
Ludovico Furlan, Monica Solbiati, Veronica Pacetti, Franca Dipaola, Martino Meda, Mattia Bonzi, Elisa Fiorelli, Giulia Cernuschi, Daniele Alberio, Giovanni Casazza, Nicola Montano, Raffaello Furlan, Giorgio Costantino
PURPOSE: Syncope is a common condition that affects individuals of all ages and is responsible for 1-3% of all emergency department (ED) visits. Prospective studies on syncope are often limited by the exiguous number of subjects enrolled. A possible alternative approach would be to use of hospital discharge diagnoses from administrative databases to identify syncope subjects in epidemiological observational studies. We assessed the accuracy of the International Classification of Diseases, Ninth Revision (ICD-9) code 780...
February 12, 2018: Clinical Autonomic Research: Official Journal of the Clinical Autonomic Research Society
Gabriella Fabbrocini, Sara Cacciapuoti, Giuseppe Monfrecola
INTRODUCTION: The negative impact of acne on aspects of health-related quality of life (HRQL) has been demonstrated in many quantitative studies; however, there has been relatively little qualitative research exploring the impact of acne and the use of topical treatment. The study aimed to explore the impact of moderate-severe acne on HRQL in adolescents and adults with inflammatory and non-inflammatory lesions and to develop a conceptual model to illustrate the impact. In addition, the study aimed to identify the attributes of topical acne treatments that are most important for patients...
March 2018: Dermatology and Therapy
Sophie Sarrassat, Nicolas Meda, Hermann Badolo, Moctar Ouedraogo, Henri Some, Robert Bambara, Joanna Murray, Pieter Remes, Matthiew Lavoie, Simon Cousens, Roy Head
BACKGROUND: Media campaigns can potentially reach a large audience at relatively low cost but, to our knowledge, no randomised controlled trials have assessed their effect on a health outcome in a low-income country. We aimed to assess the effect of a radio campaign addressing family behaviours on all-cause post-neonatal under-5 child mortality in rural Burkina Faso. METHODS: In this repeated cross-sectional, cluster randomised trial, clusters (distinct geographical areas in rural Burkina Faso with at least 40 000 inhabitants) were selected by Development Media International based on their high radio listenership (>60% of women listening to the radio in the past week) and minimum distances between radio stations to exclude population-level contamination...
March 2018: Lancet Global Health
Adama Sana, Serge M A Somda, Nicolas Meda, Catherine Bouland
Introduction: Chronic obstructive pulmonary disease (COPD) is a major and growing cause of morbidity and mortality worldwide. The global prevalence of COPD is growing faster in women than in men. Women are often exposed to indoor pollutants produced by biomass fuels burning during household activities. Methods: We conducted a meta-analysis to establish the association between COPD and exposure to biomass smoke in women.Following Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, we searched MEDLINE and Scopus databases in 31December 2016, with the terms: "wood", "charcoal", "biomass", "solid fuels", "organic fuel", "biofuel", "female", "women", "COPD", "chronic bronchitis", "emphysema", "chronic obstructive pulmonary disease"...
2018: BMJ Open Respiratory Research
Angeliki Papadaki, Laura Johnson, Zoi Toumpakari, Clare England, Manmita Rai, Stu Toms, Chris Penfold, Itziar Zazpe, Miguel A Martínez-González, Gene Feder
The aim of this study was to examine the validity of the English version of the PREvencion con DIetaMEDiterranea (PREDIMED) 14-item Mediterranean Diet Adherence Screener (MEDAS), a brief questionnaire assessing adherence to the Mediterranean diet (MedDiet), which was used in the PREDIMED trial for assessment and immediate feedback. This instrument (MEDAS) was administered to 96 adults with a high cardiovascular risk (66% women, mean age 68.3 ± 6.0 years), recruited from general practices in Bristol, UK. Participants then completed a 3-day estimated food record, and the MEDAS was administered again one month later...
January 28, 2018: Nutrients
Giuseppe Pisano, Enrico Erdas, Fabio Medas, Umberto Pisano, Pietro Giorgio Calò
Transanal intestinal evisceration is a very uncommon and dramatic occurrence, linked most frequently to rectal prolapse rupture or, very rarely, to traumatic pathology. The Authors describe a case of a 74-year-old female patient who required urgent hospital admission because of a seemingly strangulated rectal prolapse. During surgical preparation the protruding mass was recognized as small bowel loops herniating from the anus. Evisceration was due to spontaneous rectal wall rupture, most likely caused by increased abdominal pressure and consequent breach through the weakened rectum...
November 20, 2017: Annali Italiani di Chirurgia
Fabio Medas, Ernico Erdas, Gian Luigi Canu, Alessandro Longheu, Giuseppe Pisano, Massimiliano Tuveri, Pietro Giorgio Calò
BACKGROUND: Hyperthyroidism is associated with high incidence of thyroid carcinoma; furthermore, tumors arisen in hyperthyroid tissue show an aggressive behavior. Thyroid Stimulating Hormone (TSH) and Thyroid-stimulating antibodies, present in Graves's disease, seem to play a key role in carcinogenesis and tumoral growth. METHODS: We retrospectively reviewed our series of patients who underwent thyroidectomy for thyroid carcinoma. We compared pathological features and surgical outcomes of hyperthyroid versus euthyroid patients...
January 22, 2018: Journal of Otolaryngology—Head & Neck Surgery
Joseph K Wulifan, Albrecht Jahn, Hervé Hien, Patrick Christian Ilboudo, Nicolas Meda, Paul Jacob Robyn, T Saidou Hamadou, Ousmane Haidara, Manuela De Allegri
BACKGROUND: Unmet need for family planning has implications for women and their families, such as unsafe abortion, physical abuse, and poor maternal health. Contraceptive knowledge has increased across low-income settings, yet unmet need remains high with little information on the factors explaining it. This study assessed factors associated with unmet need among pregnant women in rural Burkina Faso. METHOD: We collected data on pregnant women through a population-based survey conducted in 24 rural districts between October 2013 and March 2014...
December 19, 2017: BMC Pregnancy and Childbirth
Prasanthi Malapati, Vagolu Siva Krishna, Radhika Nallangi, Nikhila Meda, Rudraraju Reshma Srilakshmi, Dharmarajan Sriram
Mycobacterium tuberculosis glutamate racemase is an essential enzyme involved in peptidoglycan synthesis and conserved in most bacteria. Small molecule inhibitors were reported on other bacterial species whereas in M. tuberculosis it wasn't explored much. In this study we have screened in house compound library using fluorescence thermal shift assay and enzyme inhibition assay, form this (1-(3-(benzo[d]thiazol-2-yl)phenyl)-3-(p-tolyl)thiourea) was identified as lead compound with IC50 19.47 ± 0.81 μM...
November 21, 2017: Bioorganic & Medicinal Chemistry
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