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Helen A Kelly, Bernard Sawadogo, Admire Chikandiwa, Michel Segondy, Clare Gilham, Olga Lompo, Tanvier Omar, Marie-Noelle Didelot, Nicolas Nagot, Nicolas Meda, Helen A Weiss, Sinead Delany-Moretlwe, Philippe Mayaud
OBJECTIVE: To describe the effect of antiretroviral therapy (ART) and HIV-related factors on high-risk human papillomavirus (HR-HPV) and high-grade cervical intraepithelial neoplasia lesions (CIN2+) among women living with HIV/AIDS (WLHA) in sub-Saharan Africa. DESIGN: Prospective cohort of WLHA in Ouagadougou, Burkina Faso (BF) and Johannesburg, South Africa (SA). Recruitment was stratified by ART status. METHODS: At baseline and endline (median 16 months), cervical samples and biopsies were analyzed for HPV genotyping (InnoLiPA) and by histology...
October 14, 2016: AIDS
Meda Kondolot, Selim Doganay, Cüneyt Turan, Hasim Asil, Didem B Oztop, Caglar Ozdemir
Visceral injuries are not uncommon in nonaccidental trauma and often require emergent operative intervention. However, sometimes it can be difficult to assess the extent of injury. In this report, we present a case of child physical abuse resulting in bladder and rectal perforations, which was initially referred to our hospital as acute abdomen with intraperitoneal free fluid on ultrasonography. An exploratory laparotomy revealed the perforations and surgical repair was performed. The patient was evaluated by the Hospital Child Protective team and it was revealed that bladder and rectum perforations were due to insertion of rolling pin into the rectum by the stepmother...
October 4, 2016: Pediatric Emergency Care
Anca Meda Georgescu, Leonard Azamfirei, Krisztina Szalman, Edit Szekely
BACKGROUND: Over the last decades Staphylococcus aureus (SA) has become the dominant etiology of native valve infective endocarditis, with the community-acquired methicillin-sensible Staphylococcus aureus (CA-MSSA) strains being the prevailing type. CASE: We report here a case of extremely severe CA-MSSA aortic valve acute endocarditis associated with persistent Staphylococcus aureus bacteremia (SAB) in a previously healthy man and include a literature review.The patient developed severe and rare complications (purpura, purulent pericarditis, intracerebral hematoma, and rhabdomyolysis) through systemic embolism; they required drainage of pericardial empyema and cerebral hematoma, the latter eventually caused a fatal outcome...
October 2016: Medicine (Baltimore)
Kahabi Ganka Isangula, Megan E Kassick, Allan Kaijunga Kairuki, Robson Amunga Meda, Erica Thomas, Akwila Temu, Georgina Msemo, Mary Azayo, Brett D Nelson
OBJECTIVES: Worldwide, there has been renewed emphasis on reducing neonatal mortality in low-resource countries. The Helping Babies Breathe (HBB) programme has been shown to reduce newborn deaths. The aim of this study is to present provider-level perceptions and experiences of the HBB programme implemented at-scale in Tanzania and identify key lessons learned for scalability in similar and other settings. METHODS: Focus group discussions with HBB-trained providers were conducted using a prospective longitudinal study design between October 2013 and May 2015...
September 29, 2016: Paediatrics and International Child Health
Meda Kondolot, Duygu Horoz, Serpil Poyrazoğlu, Arda Borlu, Ahmet Öztürk, Selim Kurtoğlu, Mümtaz M Mazicioğlu
OBJECTIVE: Limited information is available about the use of neck circumference (NC) to determine the obesity in preschool children. This study aims to provide NC percentiles and determine the cut-off levels of NC as an additional measurement for obesity in preschool children. METHODS: The data was obtained from the Anthropometry of Turkish Children aged 0-6 years (ATCA-06) study database. A total of 21 Family Health Centers were chosen and children aged 2-6 years old were randomly selected according to the socioeconomic level from the list of district midwives...
September 23, 2016: Journal of Clinical Research in Pediatric Endocrinology
Da-Hui Li, Xiao-Yan Zhang, Chao Du, Wen-Hao Zhang, Jun Chang, Yu-Jie Ma, Zhi-Chao Li, Si-Guo Hao, Hao Ding, Rong Tao
No abstract text is available yet for this article.
September 23, 2016: Leukemia & Lymphoma
O Miró, F J Martín-Sánchez, J Jacob, J A Andueza, P Herrero, P Llorens
BACKGROUND: Analyze the adherence to the Mediterranean diet (MeD) by patients with heart failure (HF) Method. We included consecutive patients diagnosed with HF in 4 hospitals. The data collected included epidemiologi-cal, comorbidities, basal situation and usual treatment. Adherence to the MeD was assessed by telephone interview with the MEDAS-14 questionnaire. RESULTS: A total of 411 patients were included: age 77 (15) years, 56% women, with a high number of risk factors and cardiovascular comorbidity, 58...
2016: Anales del Sistema Sanitario de Navarra
E Erdas, F Medas, G Pisano, A Nicolosi, P G Calò
PURPOSE: A meta-analysis was performed to asses whether antibiotic prophylaxis is effective in reducing the incidence of surgical site infection (SSI) after open mesh repair of groin hernia. METHODS: A literature search for randomized controlled trials (RCT) evaluating the effectiveness of antibiotic prophylaxis in adult patients undergoing open mesh repair of groin hernia was performed in November 2015. Incidence of overall and deep SSI was considered as primary and secondary outcome measures, respectively...
September 3, 2016: Hernia: the Journal of Hernias and Abdominal Wall Surgery
Joseph C Dysthe, Kellie J Carim, Yvette M Paroz, Kevin S McKelvey, Michael K Young, Michael K Schwartz
Loach minnow (Rhinichthys cobitis) and spikedace (Meda fulgida) are legally protected with the status of Endangered under the U.S. Endangered Species Act and are endemic to the Gila River basin of Arizona and New Mexico. Efficient and sensitive methods for monitoring these species' distributions are critical for prioritizing conservation efforts. We developed quantitative PCR assays for detecting loach minnow and spikedace DNA in environmental samples. Each assay reliably detected low concentrations of target DNA without detection of non-target species, including other cyprinid fishes with which they co-occur...
2016: PloS One
Solange Odile Yugbaré Ouédraogo, Désiré Méda, Lassina Dao, Fla Kouéta, Kam Ludovic, Ramata Ouédraogo Traoré, Diarra Yé
No abstract text is available yet for this article.
2016: Pan African Medical Journal
Jia-Kang Wang, Shu-Wen Chang
The aim of this study was to compare the refractive errors after uneventful phacoemulsification and intraocular lens implantation in the cases of vitrectomized eyes and non-vitrectomized eyes. Vitrectomized eyes were divided into 2 groups: vitrectomy alone as Group 1, vitrectomy with gas tamponade as Group 2. Normal-controlled eyes were categorized as Group 3. Intraocular lens (IOL) power calculation and the measurements of axial length (AL) and keratometric value (K) were performed using the IOLMaster and the Haigis and SRK/T formula as subgroup A and B...
August 25, 2016: International Ophthalmology
Meda Sandra Orasan, Iulia Ioana Roman, Andrei Coneac, Adriana Muresan, Remus Ioan Orasan
Research in the field of reversal hair loss remains a challenging subject. As Minoxidil 2% or 5% and Finasteride are so far the only FDA approved topical treatments for inducing hair regrowth, research is necessary in order to improve therapeutical approach in alopecia. In vitro studies have focused on cultures of a cell type - dermal papilla or organ culture of isolated cell follicles. In vivo research on this topic was performed on mice, rats, hamsters, rabbits, sheep and monkeys, taking into consideration the advantages and disadvantages of each animal model and the depilation options...
2016: Clujul Medical (1957)
Renato Polimanti, Qian Wang, Shashwath A Meda, Krishna T Patel, Godfrey D Pearlson, Hongyu Zhao, Lindsay A Farrer, Henry R Kranzler, Joel Gelernter
To identify genetic mechanisms involved in the interplay of risky sexual behaviors (RSBs) and alcohol dependence (AD), we conducted genome-wide gene-by-AD (GW-GxAD) analyses of RSB in 3924 alcohol-exposed and sexually-experienced subjects. RSBs were defined as a score based on lifetime experiences of unprotected sex and multiple sexual partners. Diagnosis of lifetime AD was defined by DSM-IV criteria. To follow-up the genetic findings, functional magnetic resonance imaging (fMRI) analyses were conducted in an independent sample...
August 17, 2016: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
Gökmen Zararsız, Betül Çiçek, Meda Kondolot, M Mümtaz Mazıcıoğlu, Ahmet Öztürk, Selim Kurtoğlu
OBJECTIVE: We aimed to compare updated weight and height percentiles of 6-17 year-old children in Kayseri with the previous local references and some other national and international data. METHODS: The second study "Determination of Anthropometric Measurements of Turkish Children and Adolescents study (DAMTCA II)" was conducted in Kayseri, between October 2007 and April 2008. Weight and height measurements from 4.321 (1.926 boys, 2.395 girls) school children (aged between 6 to 17 years) from all socioeconomic levels were included in this cross-sectional study...
August 10, 2016: Journal of Clinical Research in Pediatric Endocrinology
Daniel Murphy, Charles E McCulloch, Feng Lin, Tanushree Banerjee, Jennifer L Bragg-Gresham, Mark S Eberhardt, Hal Morgenstern, Meda E Pavkov, Rajiv Saran, Neil R Powe, Chi-Yuan Hsu
Background: Trends in the prevalence of chronic kidney disease (CKD) are important for health care policy and planning. Objective: To update trends in CKD prevalence. Design: Repeated cross-sectional study. Setting: NHANES (National Health and Nutrition Examination Survey) for 1988 to 1994 and every 2 years from 1999 to 2012. Participants: Adults aged 20 years or older. Measurements: Chronic kidney disease (stages 3 and 4) was defined as an estimated glomerular filtration rate (eGFR) of 15 to 59 mL/min/1...
October 4, 2016: Annals of Internal Medicine
M K O'Gallagher, M A Lagan, C P Mulholland, M Parker, G McGinnity, E M McLoone
PurposeThis study aims to evaluate the accuracy of lens prediction formulae on a paediatric population.MethodsA retrospective case-note review was undertaken of patients under 8 years old who underwent cataract surgery with primary lens implantation in a regional referral centre for paediatric ophthalmology, excluding those whose procedure was secondary to trauma. Biometric and refractive data were analysed for 43 eyes, including prediction errors (PE). Statistical measures used included mean absolute error (MAE), median absolute error (MedAE), Student's t-test and Lin's correlation coefficient...
September 2016: Eye
Ulrich Siler, Susana Romao, Emilio Tejera, Oleksandr Pastukhov, Elena Kuzmenko, Rocio G Valencia, Virginia Meda Spaccamela, Bernd H Belohradsky, Oliver Speer, Markus Schmugge, Elisabeth Kohne, Manfred Hoenig, Joachim Freihorst, Ansgar S Schulz, Janine Reichenbach
BACKGROUND: Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most common enzymatic disorder of red blood cells in human subjects, causing hemolytic anemia linked to impaired nicotinamide adenine dinucleotide phosphate (NADPH) production and imbalanced redox homeostasis in erythrocytes. Because G6PD is expressed by a variety of hematologic and nonhematologic cells, a broader clinical phenotype could be postulated in G6PD-deficient patients. We describe 3 brothers with severe G6PD deficiency and susceptibility to bacterial infection...
July 22, 2016: Journal of Allergy and Clinical Immunology
Robert B Zurier, Sumner H Burstein
Cannabinoids apparently act on inflammation through mechanisms different from those of agents such as nonsteroidal anti-inflammatory drugs (NSAIDs). As a class, the cannabinoids are generally free from the adverse effects associated with NSAIDs. Their clinical development thus provides a new approach to treatment of diseases characterized by acute and chronic inflammation and fibrosis. A concise survey of the anti-inflammatory actions of the phytocannabinoids Δ(9)-tetrahydrocannabinol (THC), cannabidiol, cannabichromene, and cannabinol is presented...
July 19, 2016: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
Sara Piga, Francesco Negro, Stefano Meda, Andrea Bertuglia
A 5-year-old female Siamang (Hylobates syndactilus) in captivity sustained a displaced closed fracture of the proximal phalanx of the middle digit, resulting in finger deformity and hand functional disability. Anatomical reduction and stabilization of the fracture were obtained surgically using two multifilament wire sutures. The primate had a successful functional recovery.
July 15, 2016: Journal of Medical Primatology
Benjamin O Yarnoff, Thomas J Hoerger, Siobhan A Simpson, Meda E Pavkov, Nilka R Burrows, Sundar S Shrestha, Desmond E Williams, Xiaohui Zhuo
BACKGROUND: Although major guidelines uniformly recommend iron supplementation and erythropoietin stimulating agents (ESAs) for managing chronic anemia in persons with chronic kidney disease (CKD), there are differences in the recommended hemoglobin (Hb) treatment target and no guidelines consider the costs or cost-effectiveness of treatment. In this study, we explored the most cost-effective Hb target for anemia treatment in persons with CKD stages 3-4. METHODS AND FINDINGS: The CKD Health Policy Model was populated with a synthetic cohort of persons over age 30 with prevalent CKD stages 3-4 (i...
2016: PloS One
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