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https://www.readbyqxmd.com/read/29243970/reactive-oxygen-species-damage-drives-cardiac-and-mitochondrial-dysfunction-following-acute-nano-titanium-dioxide-inhalation-exposure
#1
Cody E Nichols, Danielle L Shepherd, Quincy A Hathaway, Andrya J Durr, Dharendra Thapa, Alaeddin Abukabda, Jinghai Yi, Timothy R Nurkiewicz, John M Hollander
Nanotechnology offers innovation in products from cosmetics to drug delivery, leading to increased engineered nanomaterial (ENM) exposure. Unfortunately, health impacts of ENM are not fully realized. Titanium dioxide (TiO2) is among the most widely produced ENM due to its use in numerous applications. Extrapulmonary effects following pulmonary exposure have been identified and may involve reactive oxygen species (ROS). The goal of this study was to determine the extent of ROS involvement on cardiac function and the mitochondrion following nano-TiO2 exposure...
December 15, 2017: Nanotoxicology
https://www.readbyqxmd.com/read/29243830/proceedings-of-the-food-and-drug-administration-s-public-workshop-on-new-red-blood-cell-product-regulatory-science-2016
#2
Jaroslav G Vostal, Paul W Buehler, Monique P Gelderman, Abdu I Alayash, Alan Doctor, James C Zimring, Simone A Glynn, John R Hess, Harvey Klein, Jason P Acker, Philip C Spinella, Angelo D'Alessandro, Bernhard Palsson, Thomas J Raife, Michael P Busch, Timothy J McMahon, Marcos Intaglietta, Harold M Swartz, Michael A Dubick, Sylvain Cardin, Rakesh P Patel, Charles Natanson, John W Weisel, Jennifer A Muszynski, Philip J Norris, Paul M Ness
The US Food and Drug Administration (FDA) held a workshop on red blood cell (RBC) product regulatory science on October 6 and 7, 2016, at the Natcher Conference Center on the National Institutes of Health (NIH) Campus in Bethesda, Maryland. The workshop was supported by the National Heart, Lung, and Blood Institute, NIH; the Department of Defense; the Office of the Assistant Secretary for Health, Department of Health and Human Services; and the Center for Biologics Evaluation and Research, FDA. The workshop reviewed the status and scientific basis of the current regulatory framework and the available scientific tools to expand it to evaluate innovative and future RBC transfusion products...
December 15, 2017: Transfusion
https://www.readbyqxmd.com/read/29243275/in-vitro-toxicity-assessment-of-nanocrystals-in-tissue-type-cells-and-macrophage-cells
#3
Meiling Chen, Ying Li, Jiezhao Zhou, Zhenbo Yang, Zhiyuan Wang, Yang Yang, Hui Zhang, Zhiping Li, Xingguo Mei
Nanocrystals (NCs), a type of innovative material particle, are a potential drug delivery platform that aims to improve the bioavailability of hydrophobic drugs. However, due to the lack of consideration of their toxicity, existing studies have not investigated whether the nanoscale properties of NCs, such as particle sizes, may lead to NC-induced toxicity. Because of the disparity between the rapid development of NCs and the lack of studies regarding NC toxicity, the present study investigated possible NC toxicity and clarified the relationship between particle sizes and NC toxicity...
December 15, 2017: Journal of Applied Toxicology: JAT
https://www.readbyqxmd.com/read/29242901/designed-host-defense-peptides-for-the-treatment-of-bacterial-keratitis
#4
L Edward Clemens, Jesse Jaynes, Edward Lim, Satya S Kolar, Rose Y Reins, Hasna Baidouri, Samuel Hanlon, Alison M McDermott, Kathryn W Woodburn
Purpose: To limit corneal damage and potential loss of vision, bacterial keratitis must be treated aggressively. Innovation in antimicrobials is required due to the need for empirical treatment and the rapid emergence of bacterial resistance. Designed host defense peptides (dHDPs) are synthetic analogues of naturally occurring HDPs, which provide defense against invading pathogens. This study investigates the use of novel dHDPs for the treatment of bacterial keratitis. Methods: The minimum inhibitory concentrations (MICs) were determined for dHDPs on both Gram-positive and -negative bacteria...
December 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29242379/high-throughput-and-sensitive-immunopeptidomics-platform-reveals-profound-ifn%C3%AE-mediated-remodeling-of-the-hla-ligandome
#5
Chloe Chong, Fabio Marino, Hui-Song Pak, Julien Racle, Roy T Daniel, Markus Müller, David Gfeller, George Coukos, Michal Bassani-Sternberg
Comprehensive knowledge of the human leukocyte antigen (HLA) class-I and class-II peptides presented to T-cells is crucial for designing innovative therapeutics against cancer and other diseases. However methodologies for their purification for mass-spectrometry analysis have been a major limitation. We designed a novel high-throughput, reproducible and sensitive method for sequential immuno-affinity purification of HLA-I and -II peptides from up to 96 samples in a plate format, suitable for both cell lines and tissues...
December 14, 2017: Molecular & Cellular Proteomics: MCP
https://www.readbyqxmd.com/read/29240712/developing-an-agent-based-drug-model-to-investigate-the-synergistic-effects-of-drug-combinations
#6
Hongjie Gao, Zuojing Yin, Zhiwei Cao, Le Zhang
The growth and survival of cancer cells are greatly related to their surrounding microenvironment. To understand the regulation under the impact of anti-cancer drugs and their synergistic effects, we have developed a multiscale agent-based model that can investigate the synergistic effects of drug combinations with three innovations. First, it explores the synergistic effects of drug combinations in a huge dose combinational space at the cell line level. Second, it can simulate the interaction between cells and their microenvironment...
December 14, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29240330/regulating-black-box-medicine
#7
W Nicholson Price
Data drive modern medicine. And our tools to analyze those data are growing ever more powerful. As health data are collected in greater and greater amounts, sophisticated algorithms based on those data can drive medical innovation, improve the process of care, and increase efficiency. Those algorithms, however, vary widely in quality. Some are accurate and powerful, while others may be riddled with errors or based on faulty science. When an opaque algorithm recommends an insulin dose to a diabetic patient, how do we know that dose is correct? Patients, providers, and insurers face substantial difficulties in identifying high-quality algorithms; they lack both expertise and proprietary information...
2017: Michigan Law Review
https://www.readbyqxmd.com/read/29239690/antibody-drug-conjugates-design-and-development-for-therapy-and-imaging-in-and-beyond-cancer-labex-mabimprove-industrial-workshop-july-27-28-2017-tours-france
#8
Camille Martin, Claire Kizlik-Masson, André Pèlegrin, Hervé Watier, Marie-Claude Viaud-Massuard, Nicolas Joubert
The annual "Antibody Industrial Symposium", co organized by LabEx MAbImprove, MabDesign and Polepharma, was held in Tours, France on June 27-28, 2017. The focus was on antibody-drug-conjugates (ADCs), new entities which realize the hope of Paul Ehrlich's magic bullet. ADCs result from the bioconjugation of a highly cytotoxic drug to a selective monoclonal antibody, which acts as a vector. Building on knowledge gained during the development of three approved ADCs, brentuximab vedotin (Adcetris®), ado trastuzumab emtansine (Kadcyla®) and inotuzumab ozogamicin (Besponsa®), and the many ADCs in development, this meeting addressed strategies and the latest innovations in the field from fundamental research to manufacturing...
December 14, 2017: MAbs
https://www.readbyqxmd.com/read/29239595/explaining-the-absence-of-surgical-procedure-regulation
#9
Jonathan J Darrow
Each year in the United States, surgeons perform approximately 64 million surgical procedures, ranging from tooth extraction to open heart surgery. Yet, notwithstanding the frequency of surgical procedures and their often critical importance to patient health, no state or federal agency either approves the use of new surgical procedures or directly regulates existing procedures. The absence of surgical procedure regulation differs from the regulation of new pharmaceutical products, which can be introduced into interstate commerce only after the Food and Drug Administration (FDA) has reviewed "adequate and well-controlled [clinical] investigations" and concluded the data from those studies sufficiently establish the drug's safety and efficacy...
2017: Cornell Journal of Law and Public Policy
https://www.readbyqxmd.com/read/29239189/-immunotherapy-in-the-treatment-of-lung-cancer
#10
O Fiala, O Šorejs, M Pešek, J Fínek
BACKGROUND: Lung cancer occupies the leading position of cancer incidence and mortality worldwide, including in the Czech Republic. Despite significant advances in systemic oncology treatments, lung cancer still has the worst prognosis, which is driving the need for innovative therapies and methods to treat this disease. Immunotherapy is a developing area of systemic oncology treatment, which has recently begun to be significantly applied to patients with lung carcinoma. The most useful type of immunotherapy currently employs checkpoint inhibitors, including CTLA-4 inhibitors (ipilimumab and tremelimumab) and PD-1/PD-L1 inhibitors (nivolumab, pembrolizumab, durvalumab, and avelumab)...
2017: Klinická Onkologie: Casopis Ceské a Slovenské Onkologické Spolecnosti
https://www.readbyqxmd.com/read/29238188/effects-of-major-parameters-of-nanoparticles-on-their-physical-and-chemical-properties-and-recent-application-of-nanodrug-delivery-system-in-targeted-chemotherapy
#11
REVIEW
Jing Zhang, Hua Tang, Zefa Liu, Baoan Chen
Chemotherapy is still one of the main cancer therapy treatments, but the curative effect of chemotherapy is relatively low, as such the development of a new cancer treatment is highly desirable. The gradual maturation of nanotechnology provides an innovative perspective not only for cancer therapy but also for many other applications. There are a diverse variety of nanoparticles available, and choosing the appropriate carriers according to the demand is the key issue. The performance of nanoparticles is affected by many parameters, mainly size, shape, surface charge, and toxicity...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29236237/outcome-of-children-and-adolescents-with-central-nervous-system-tumors-in-phase-i-trials
#12
Fernando Carceller, Francisco Bautista, Irene Jiménez, Raquel Hladun-Álvaro, Cécile Giraud, Luca Bergamaschi, Madhumita Dandapani, Isabelle Aerts, François Doz, Didier Frappaz, Michela Casanova, Bruce Morland, Darren R Hargrave, Gilles Vassal, Andrew D J Pearson, Birgit Geoerger, Lucas Moreno, Lynley V Marshall
Central nervous system (CNS) tumors are a leading cause of death in pediatric oncology. New drugs are desperately needed to improve survival. We evaluated the outcome of children and adolescents with CNS tumors participating in phase I trials within the Innovative Therapies for Children with Cancer (ITCC) consortium. Patients with solid tumors aged < 18 years at enrollment in their first dose-finding trial between 2000 and 2014 at eight ITCC centers were included retrospectively. Survival was evaluated using univariate/multivariate analyses...
December 13, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/29234483/the-influence-of-emerging-markets-on-the-pharmaceutical-industry
#13
REVIEW
Maya Tannoury, Zouhair Attieh
Emerging markets represent an exceptional opportunity for the pharmaceutical industry. Although a precise definition is not yet available, economists define emerging markets as developing prosperous countries in which investment is expected to result in higher income despite high risks. Qualifying a market as emerging is not merely based on the economic status of the country, but also on several criteria that render the definition applicable to each country. Jim O'Neil, retired chairman of asset management at Goldman Sachs, identified leading economies of emerging markets: Brazil, Russia, India, and China (BRIC) and later Brazil, Russia, India, China, and South Africa (BRICS) and then Mexico, Indonesia, South Korea, and Turkey (MIST), which followed years later as the second tier of nations...
2017: Current Therapeutic Research, Clinical and Experimental
https://www.readbyqxmd.com/read/29234063/the-sam-sam-interaction-between-ship2-and-the-epha2-receptor-design-and-analysis-of-peptide-inhibitors
#14
Flavia Anna Mercurio, Concetta Di Natale, Luciano Pirone, Roberta Iannitti, Daniela Marasco, Emilia Maria Pedone, Rosanna Palumbo, Marilisa Leone
The lipid phosphatase Ship2 represents a drug discovery target for the treatment of different diseases, including cancer. Its C-terminal sterile alpha motif domain (Ship2-Sam) associates with the Sam domain from the EphA2 receptor (EphA2-Sam). This interaction is expected to mainly induce pro-oncogenic effects in cells therefore, inhibition of the Ship2-Sam/EphA2-Sam complex may represent an innovative route to discover anti-cancer therapeutics. In the present work, we designed and analyzed several peptide sequences encompassing the interaction interface of EphA2-Sam for Ship2-Sam...
December 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29233449/a-pilot-study-assessing-the-value-of-3d-printed-molecular-modelling-tools-for-pharmacy-student-education
#15
Susan Hall, Gary Grant, Devinder Arora, Abdullah Karaksha, Amelia McFarland, Anna Lohning, Shailendra Anoopkumar-Dukie
BACKGROUND AND PURPOSE: Medicinal chemistry and pharmacology are difficult topics to both teach and learn given the complex nature of drug mechanisms and drug-receptor interactions. This highlights the need for innovative teaching methods to deliver this information to students. One such method is through three-dimensional (3D) printing of enzymes and ligands in the teaching of molecular modelling concepts relating to drug-receptor and enzyme interactions be ligands. This type of printing has been shown to be beneficial in several educational settings; however, to our knowledge, its effectiveness in pharmacy, medicinal chemistry and pharmacology learning and teaching is largely unknown...
July 2017: Currents in Pharmacy Teaching & Learning
https://www.readbyqxmd.com/read/29233414/teaching-drug-utilization-review-skills-via-a-simulated-clinical-decision-making-exercise
#16
Cortney M Mospan, Katelyn M Alexander
BACKGROUND: Drug utilization review (DUR) is a central role of the pharmacist, especially within the community pharmacy setting. Previous literature has shown risk of "alert fatigue", supporting the necessity of pharmacists to utilize a step-wise approach in evaluation of drug therapy during the verification process. Many students are intimidated by this process, and may lack verification practice or experience until their first day as a licensed pharmacist. EDUCATIONAL ACTIVITY AND SETTING: An innovative skills-based laboratory exercise was developed for third-year pharmacy students to develop DUR skills...
March 2017: Currents in Pharmacy Teaching & Learning
https://www.readbyqxmd.com/read/29233399/management-education-within-pharmacy-curricula-a-need-for-innovation
#17
Cortney M Mospan
OBJECTIVE: To encourage the academy to pursue innovative management education strategies within pharmacy curricula and highlight these experiences in a scholarly dialogue. SUMMARY: Management has often been a dreaded, dry, and often neglected aspect of pharmacy curricula. With the release of Center for Advancement of Pharmacy Education (CAPE) Educational Outcomes 2013 as well as Entry-Level Competencies Needed for Community Pharmacy Practice by National Association of Chain Drug Stores (NACDS) Foundation, National Community Pharmacists Association (NCPA), and Accreditation Council for Pharmacy Education (ACPE) in 2012, managerial skills have seen a new emphasis in pharmacy education...
March 2017: Currents in Pharmacy Teaching & Learning
https://www.readbyqxmd.com/read/29233212/percutaneous-closure-of-a-large-patent-ductus-arteriosus-in-a-preterm-newborn-weighing-1400-g-without-using-arterial-sheath-an-innovative-technique
#18
Gaurav Garg, Vishal Garg, Amit Prakash
Percutaneous closure of patent ductus arteriosus is well established in infants weighing >5 kg, but data regarding outcome of preterm especially very low birth weight infants is minimal. Although surgical ligation of patent ductus arteriosus is the preferred and well-accepted modality of treatment after failure of drug therapy in preterm infants, it has also got its own demerits in such a small and fragile subset. Device closure in infants weighing <1.5 kg is rarely attempted because of high chances of complications, especially acute arterial injury due to the arterial sheath...
December 13, 2017: Cardiology in the Young
https://www.readbyqxmd.com/read/29231904/protective-effects-of-%C3%AF-3-pufa-in-anthracycline-induced-cardiotoxicity-a-critical-review
#19
REVIEW
Simona Serini, Renata Ottes Vasconcelos, Renata Nascimento Gomes, Gabriella Calviello
It has been demonstrated that ω-3 polyunsaturated fatty acids (ω-3 PUFA) may exert a beneficial role as adjuvants in the prevention and treatment of many disorders, including cardiovascular diseases and cancer. Particularly, several in vitro and in vivo preclinical studies have shown the antitumor activity of ω-3 PUFA in different kinds of cancers, and several human studies have shown that ω-3 PUFA are able to decrease the risk of a series of cardiovascular diseases. Several mechanisms have been proposed to explain their pleiotropic beneficial effects...
December 12, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29231691/medical-devices-gastroenterology-urology-devices-classification-of-the-prostatic-artery-embolization-device-final-order
#20
(no author information available yet)
The Food and Drug Administration (FDA or we) is classifying the prostatic artery embolization device into class II (special controls). The special controls that apply to the device type are identified in this order and will be part of the codified language for the prostatic artery embolization device's classification. We are taking this action because we have determined that classifying the device into class II (special controls) will provide a reasonable assurance of safety and effectiveness of the device...
November 14, 2017: Federal Register
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