Shalini Mani, Divya Jindal, Hitesh Chopra, Saurabh Kumar Jha, Sachin Kumar Singh, Gulam Md Ashraf, Mehnaz Kamal, Danish Iqbal, Dinesh Kumar Chellappan, Abhijit Dey, Saikat Dewanjee, Keshav K Singh, Shreesh Ojha, Inderbir Singh, Rupesh K Gautam, Niraj Kumar Jha
Neurons depend on mitochondrial functions for membrane excitability, neurotransmission, and plasticity.Mitochondrialdynamicsare important for neural cell maintenance. To maintain mitochondrial homeostasis, lysosomes remove dysfunctionalmitochondria through mitophagy. Mitophagy promotes mitochondrial turnover and prevents the accumulation of dysfunctional mitochondria. In many neurodegenerative diseases (NDDs), including Alzheimer's disease (AD), mitophagy is disrupted in neurons.Mitophagy is regulated by several proteins; recently,Rho-associated coiled-coil containing protein kinase 2 (ROCK2) has been suggested to negatively regulate the Parkin-dependent mitophagy pathway...
September 16, 2022: Neuroscience and Biobehavioral Reviews