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Hyperglycemia neonate

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https://www.readbyqxmd.com/read/27909691/6q24-transient-neonatal-diabetes-how-to-manage-while-waiting-for-genetic-results
#1
Julie Fudvoye, Khaldoun Farhat, Virginie De Halleux, Corina Ramona Nicolescu
Diabetes, rare in the neonatal period, should be evoked in every newborn presenting with unexplained intrauterine and early postnatal growth retardation. This case report illustrates the clinical course and therapeutic approach of a newborn diagnosed with transient diabetes. The baby was born at 37 weeks of gestation with a severe intrauterine growth restriction. Except a mild macroglossia and signs of growth restriction, physical examination was normal. On the fifth day of life, hyperglycemia (180 mg/dl) was noted, and the next day, the diagnosis of diabetes was confirmed (high blood sugar, glucosuria, undetectable levels of insulin and C-peptide)...
2016: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/27869777/the-effects-of-mild-gestational-hyperglycemia-on-exclusive-breastfeeding-cessation
#2
Sergio Verd, Diego de Sotto, Consuelo Fernández, Antonio Gutiérrez
Gestational diabetes increases the risk of a range of adverse perinatal outcomes, including breastfeeding failure, but the best cut-off point for gestational diabetes is unknown. The purpose of this study was to evaluate the association between mild gestational glucose tolerance impairment and the early cessation of exclusive breastfeeding (EBF). This is an observational study of 768 women with full term pregnancies that were screened for gestational diabetes at 24-28 weeks gestation. Subjects were divided into two groups: those with a normal 1-h glucose challenge test and those with an elevated 1-h glucose challenge test but still did not qualify for gestational diabetes...
November 19, 2016: Nutrients
https://www.readbyqxmd.com/read/27854328/parenchymal-and-stromal-cells-contribute-to-pro-inflammatory-myocardial-environment-at-early-stages-of-diabetes-protective-role-of-resveratrol
#3
Monia Savi, Leonardo Bocchi, Roberto Sala, Caterina Frati, Costanza Lagrasta, Denise Madeddu, Angela Falco, Serena Pollino, Letizia Bresciani, Michele Miragoli, Massimiliano Zaniboni, Federico Quaini, Daniele Del Rio, Donatella Stilli
Background: Little information is currently available concerning the relative contribution of cardiac parenchymal and stromal cells in the activation of the pro-inflammatory signal cascade, at the initial stages of diabetes. Similarly, the effects of early resveratrol (RSV) treatment on the negative impact of diabetes on the different myocardial cell compartments remain to be defined. Methods: In vitro challenge of neonatal cardiomyocytes and fibroblasts to high glucose and in vivo/ex vivo experiments on a rat model of Streptozotocin-induced diabetes were used to specifically address these issues...
November 16, 2016: Nutrients
https://www.readbyqxmd.com/read/27817783/-pancytopenia-and-metabolic-decompensation-in-a-neonate
#4
Jian-Qiang Tan, Da-Yu Chen, Zhen-Qin Mo, Zhe-Tao Li, Ji-Wei Huang, Ren Cai, Ti-Zhen Yan
A 9-day-old male patient was admitted to the hospital because of cough, anhelation, feeding difficulty and lethargy. The diagnostic examinations indicated pulmonary infection, severe metabolic acidosis, hyperglycemia, hyperammonemia and pancytopenia in the patient. Blood and urine screening and isovaleryl-CoA dehydrogenase (IVD) gene detection for inherited metabolic diseases were performed to clarify the etiology. Tandem mass spectrometric screening for blood showed an elevated isovalerylcarnitine (C5) level...
November 2016: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/27809389/epidemiology-clinical-characteristics-and-genetic-etiology-of-neonatal-diabetes-in-japan
#5
Kazuaki Nagashima, Daisuke Tanaka, Nobuya Inagaki
Neonatal diabetes mellitus (NDM) is a rare but potentially devastating metabolic disorder, with reported incidence of one per 300,000-500,000 births generally, and hyperglycemia develops within the first 6 months of life (1-4). NDM is classified into two categories clinically. One is transient NDM (TNDM), in which insulin secretion is spontaneously recovered by several months of age, but sometimes recurs later, and the other is permanent NDM (PNDM), requiring lifelong medication. Recent molecular analysis of NDM identified at least 12 genetic abnormalities: chromosome 6q24, KCNJ11, ABCC8, INS, FOXP3, GCK, IPF1, PTF1A, EIF2AK3, GLUT2, HNF1β, and GLIS3 (5-22)...
November 3, 2016: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/27741952/maternal-antecedents-of-adiposity-and-studying-the-transgenerational-role-of-hyperglycemia-and-insulin-maasthi-a-prospective-cohort-study-protocol-of-birth-cohort-at-bangalore-india
#6
Giridhara R Babu, Gvs Murthy, R Deepa, Yamuna, Prafulla, H Kiran Kumar, Maithili Karthik, Keerti Deshpande, Sara E Benjamin Neelon, D Prabhakaran, Anura Kurpad, Sanjay Kinra
BACKGROUND: India is experiencing an epidemic of obesity-hyperglycaemia, which coincides with child bearing age for women. The epidemic can be sustained and augmented through transgenerational transmission of adiposity and glucose intolerance in women. This presents an opportunity for exploring a clear strategy for the control of this epidemic in India. We conducted a study between November 2013 and May 2015 to inform the design of a large pregnancy cohort study. Based on the findings of this pilot, we developed the protocol for the proposed birth cohort of 5000 women, the recruitment for which will start in April 2016...
October 14, 2016: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/27681178/expression-of-the-mitochondrial-calcium-uniporter-in-cardiac-myocytes-improves-impaired-mitochondrial-calcium-handling-and-metabolism-in-simulated-hyperglycemia
#7
Julieta Diaz-Juarez, Jorge Suarez, Federico Cividini, Brian T Scott, Tanja Diemer, Anzhi Dai, Wolfgang H Dillmann
Diabetic cardiomyopathy is associated with metabolic changes including decreased glucose oxidation (Gox) and increased fatty acid oxidation (FAox), which result in cardiac energetic deficiency. Diabetic hyperglycemia is a pathophysiological mechanism that triggers multiple maladaptive phenomena. The mitochondrial calcium uniporter (MCU) is the channel responsible for Ca(2+) uptake in mitochondria and free mitochondrial calcium concentration ([Ca(2+)]m) regulates mitochondrial metabolism. Experiments with cardiac myocytes (CM) exposed to simulated hyperglycemia revealed both reduced [Ca(2+)]m and MCU protein levels...
September 28, 2016: American Journal of Physiology. Cell Physiology
https://www.readbyqxmd.com/read/27671701/derangement-of-calcium-metabolism-in-diabetes-mellitus-negative-outcome-from-the-synergy-between-impaired-bone-turnover-and-intestinal-calcium-absorption
#8
Kannikar Wongdee, Nateetip Krishnamra, Narattaphol Charoenphandhu
Both types 1 and 2 diabetes mellitus (T1DM and T2DM) are associated with profound deterioration of calcium and bone metabolism, partly from impaired intestinal calcium absorption, leading to a reduction in calcium uptake into the body. T1DM is associated with low bone mineral density (BMD) and osteoporosis, whereas the skeletal changes in T2DM are variable, ranging from normal to increased and to decreased BMD. However, both types of DM eventually compromise bone quality through production of advanced glycation end products and misalignment of collagen fibrils (so-called matrix failure), thereby culminating in a reduction of bone strength...
September 26, 2016: Journal of Physiological Sciences: JPS
https://www.readbyqxmd.com/read/27659110/acute-hyperglycemia-suppresses-left-ventricular-diastolic-function-and-inhibits-autophagic-flux-in-mice-under-prohypertrophic-stimulation
#9
Jiahe Xie, Kai Cui, Huixin Hao, Yingxue Zhang, Hairuo Lin, Zhenhuan Chen, Xiaobo Huang, Shiping Cao, Wangjun Liao, Jianping Bin, Masafumi Kitakaze, Yulin Liao
BACKGROUND: Left ventricular (LV) dysfunction is closely associated with LV hypertrophy or diabetes, as well as insufficient autophagic flux. Acute or chronic hyperglycemia is a prognostic factor for patients with myocardial infarction. However, the effect of acute hyperglycemia on LV dysfunction of the hypertrophic heart and the mechanisms involved are still unclear. This study aimed to confirm our hypothesis that either acute or chronic hyperglycemia suppresses LV diastolic function and autophagic flux...
September 22, 2016: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/27634392/maternal-and-neonatal-morbidity-for-women-who-would-be-added-to-the-diagnosis-of-gdm-using-iadpsg-criteria-a-secondary-analysis-of-the-hyperglycemia-and-adverse-pregnancy-outcome-study
#10
Thaddeus P Waters, Alan R Dyer, Denise M Scholtens, Sharon L Dooley, Elaine Herer, Lynn P Lowe, Jeremy J N Oats, Bengt Persson, David A Sacks, Boyd E Metzger, Patrick M Catalano
OBJECTIVE: To assess the frequency of adverse outcomes for women who are diagnosed with gestational diabetes mellitus (GDM) by the International Association of the Diabetes and Pregnancy Study Groups (IADPSG) criteria using data from the Hyperglycemia and Adverse Pregnancy Outcome (HAPO) study. RESEARCH DESIGN AND METHODS: This is a secondary analysis from the North American HAPO study centers. Glucose measurements from a 75-g oral glucose tolerance test were used to group participants into three nonoverlapping categories: GDM based on Carpenter-Coustan (CC) criteria (also GDM based on IADPSG criteria), GDM diagnosed based on IADPSG criteria but not CC criteria, and no GDM...
December 2016: Diabetes Care
https://www.readbyqxmd.com/read/27632150/effect-of-diabetes-on-circulating-pancreatic-hormones-in-pregnant-rats-and-their-offspring
#11
I L Iessi, Y K Sinzato, F Q Gallego, J H Nielsen, D C Damasceno
The aim of the study was to investigate the role of diabetic intrauterine environment on circulating insulin, glucagon, and somatostatin levels in pregnant rats, fetuses, and offspring. Diabetes was induced in female Wistar rats by streptozotocin at birth or as adult and the animals were assigned into: control (C); mildly diabetic (MD); and severely diabetic (SD). The rats were mated and distributed into 2 subgroups: euthanasia at day 21 of pregnancy and at day 10 postpartum. Both MD and SD dams showed impaired oral glucose tolerance...
September 2016: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://www.readbyqxmd.com/read/27622484/streptozotocin-diabetogenic-action-in-an-experimental-neonatal-induction-model
#12
Leticia Bequer, Tahiry Gómez, José Luis Molina, Daniel Artiles, Rosa Bermúdez, Sonia Clapés
INTRODUCTION: The use of experimental models is essential to study the pathophysiological mechanisms of diabetes.  OBJECTIVES: To compare in adult Wistar rats the diabetogenic action of streptozotocin according to the moment and route of administration during the neonatal period by evaluating biochemical, metabolic and histological variables.  MATERIALS AND METHODS: Eight groups of neonatal female Wistar rats (n=10) were formed. We evaluated the induction with streptozotocin (100 mg/kg of body weight) on days 2 and 5 after birth, as well as the administration routes (subcutaneous or intraperitoneal)...
2016: Biomédica: Revista del Instituto Nacional de Salud
https://www.readbyqxmd.com/read/27603367/the-association-between-maternal-hyperglycemia-and-perinatal-outcomes-in-gestational-diabetes-mellitus-patients-a-retrospective-cohort-study
#13
Hee Young Cho, Inkyung Jung, So Jung Kim
Pregnancies complicated by gestational diabetes mellitus (GDM) are associated with increased risks of adverse maternal and fetal outcomes. The risks of adverse pregnancy outcomes differ depending on the glucose values among GDM patients. For accurate and effective prenatal counseling, it is necessary to understand the relationship between different maternal hyperglycemia values and the severity of adverse outcomes. With this objective, this study reexamines the relationship between maternal hyperglycemia versus maternal and perinatal outcomes in GDM patients...
September 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27578621/role-of-pancreatic-duct-cell-in-beta-cell-neogenesis-a-mini-review-study
#14
Mahsa Zare, Shahdokht Rastegar, Esmaeel Ebrahimi, Azade Roohipoor, Saeed Shirali
Today diabetes mellitus is known as main threatening for health society. Beta cells have pivotal role in energy homeostasis by balance in blood glucose. Proliferation and neogenesis are two factors for preservation of beta cell mass but these have lower rate during adulthood rather than neonatal. Beta cell destruction occurs during diabetes that leads to hyperglycemia. Continues production of beta cell is a therapeutic strategy to keep normal blood glucose and pancreatic duct cell can be one of the sources of new beta cells...
August 27, 2016: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/27561267/evaluation-of-the-pharmacokinetics-of-glibenclamide-tablet-given-off-label-orally-to-children-suffering-from-neonatal-syndromic-hyperglycemia
#15
Naïm Bouazza, Zoubir Djerada, Claire Gozalo, Kanetee Busiah, Jacques Beltrand, Marianne Berdugo, Saik Urien, Jean-Marc Treluyer, Michel Polak
PURPOSE: Glibenclamide (Gb) is used in type II diabetes mellitus but also in the last 10 years, off label, in patients with neonatal syndromic hyperglycemia carrying a mutation of Kir6.2 or SUR1. No studies have reported Gb pharmacokinetics in children. In this study, oral Gb pharmacokinetics was investigated in children in order to describe the concentration time courses, the influence of covariates, and the relationships between drug concentrations and efficacy. METHODS: Gb concentrations were measured in 18 children after the switch from subcutaneous insulin to oral tablets of Gb (crushed tablets for 33 % of patients)...
November 2016: European Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/27549179/maternal-hyperglycemia-during-labor-and-related-immediate-post-partum-maternal-and-perinatal-outcomes-at-the-yaound%C3%A3-central-hospital-cameroon
#16
Manuella Djomhou, Eugene Sobngwi, Jean Jacques N Noubiap, Mickael Essouma, Philip Nana, Nelson J Fomulu
BACKGROUND: Data on the prevalence and complications of gestational diabetes are very scarce in Cameroon. The aim of this study was to evaluate the uptake of screening for gestational diabetes and assess the immediate post-partum outcome of hyperglycemic parturient mothers and perinatal outcome of their babies. METHODS: A prospective cohort study was held at the Maternity of the Yaoundé Central Hospital from March to June 2013. One hundred volunteer women in labor without overt diabetes mellitus and having fasted for 8 to 12 h were recruited...
2016: Journal of Health, Population, and Nutrition
https://www.readbyqxmd.com/read/27540106/prematurity-and-genetic-testing-for-neonatal-diabetes
#17
Rachel E J Besser, Sarah E Flanagan, Deborah G J Mackay, I K Temple, Maggie H Shepherd, Beverley M Shields, Sian Ellard, Andrew T Hattersley
BACKGROUND: Hyperglycemia in premature infants is usually thought to reflect inadequate pancreatic development rather than monogenic neonatal diabetes. No studies, to our knowledge, have investigated the prevalence of monogenic forms of diabetes in preterm infants. METHODS: We studied 750 patients with diabetes diagnosed before 6 months of age. We compared the genetic etiology and clinical characteristics of 146 preterm patients born <37 weeks and compared them with 604 born ≥37 weeks...
September 2016: Pediatrics
https://www.readbyqxmd.com/read/27510937/controversies-in-screening-and-diagnosis-of-gestational-diabetes-cuba-s-position
#18
Jeddú Cruz-Hernández, Pilar Hernández-García, Jacinto Lang-Prieto, Marelys Yanes-Quesada, Ileydis Iglesias-Marichal, Antonio Márquez-Guillén
Gestational diabetes is the most common endocrine disorder affecting pregnant women and its prevalence is on the rise. Prevalence in Cuba is about 5.8%, and global prevalence ranges from 2% to 18% depending on the criteria applied. Gestational diabetes can lead to adverse gestational outcomes, such as fetal death, preterm delivery, dystocia, perinatal asphyxia and neonatal complications. Prompt, accurate diagnosis allowing early treatment can benefit both mother and child. The disease is asymptomatic, so clinical laboratory testing plays a key role in its screening and diagnosis...
July 2016: MEDICC Review
https://www.readbyqxmd.com/read/27493437/dying-for-milk-a-neonate-with-severe-hypernatremia-associated-with-inadequate-breast-feeding
#19
Omer S M Suliman
Inadequate breastfeeding may result in malnutrition, hypernatremic dehydration and catastrophic outcomes. We describe a case of severe breast feeding associated hypernatremia which was complicated by acute seizures and severe hyperglycemia. The baby's condition was initially confused with neonatal diabetes mellitus.
2015: Sudanese Journal of Paediatrics
https://www.readbyqxmd.com/read/27487489/novel-homozygous-likely-pathogenic-intronic-variant-in-ins-causing-permanent-neonatal-diabetes-in-siblings
#20
Rachel Courtney, Candace Gamble, Monica L Arango, Avni Shah, Nunilo I Rubio, Joanne Nguyen, David Rodriguez-Buritica
Permanent neonatal diabetes (PNDM) is a rare genetic condition characterized by hyperglycemia, insulinopenia, and failure to thrive beginning in the first 6 months of life. Recessive mutations in INS lead to decreased production of insulin via a variety of mechanisms. We present a case of two brothers, born to consanguineous parents, with a novel homozygous intronic variant in the INS gene. Each patient presented with intrauterine growth restriction (IUGR) and significant hyperglycemia within the first 24 h of life...
September 1, 2016: Journal of Pediatric Endocrinology & Metabolism: JPEM
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