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https://www.readbyqxmd.com/read/29929015/free-antero-lateral-thigh-flap-for-total-knee-prosthesis-coverage-after-infection-complicating-malignant-tumour-resection
#1
Cécile Philandrianos, Jean-Camille Mattei, Alexandre Rochwerger, Baptiste Bertrand, Charlotte Jaloux, Dominique Casanova
BACKGROUND: Infection is a common complication of major lower limb-sparing surgery with massive total knee prosthesis (MTKP) reconstruction after extensive tumour resection. When free tissue transfer is required to cover the prosthesis, musculo-cutaneous flaps are usually preferred based on proven efficacy when used in both one-stage and two-stage procedures. The use of a free fascio-cutaneous antero-lateral thigh (FC-ALT) flap in 3 patients with infected knee reconstructions is reported here...
June 18, 2018: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/29928483/mir-146a-suppresses-5-lipoxygenase-activating-protein-flap-expression-and-leukotriene-b4-production-in-lung-cancer-cells
#2
Joseph R Iacona, Nicholas J Monteleone, Carol S Lutz
Arachidonic acid (AA) can be converted into prostaglandins (PGs) or leukotrienes (LTs) by the enzymatic actions of cyclooxygenases (COX-1 and COX-2) or 5-lipoxygenase (5-LO), respectively. PGs and LTs are lipid signaling molecules that have been implicated in various diseases, including multiple cancers. 5-LO and its activating protein (FLAP) work together in the first two conversion steps of LT production. Previous work has suggested a role for LTs in cancer development and progression. MicroRNAs (miRNAs) are small RNA molecules that negatively regulate gene expression post-transcriptionally, and have previously been shown to be involved in cancer...
June 1, 2018: Oncotarget
https://www.readbyqxmd.com/read/29928092/pneumothorax-a-rare-or-underreported-complication-following-latissimus-dorsi-muscle-flap
#3
Amish Jayantilal Gohil, Subhash Sahu, Shashank Lamba, Ashish Kumar Gupta
No abstract text is available yet for this article.
January 2018: Indian Journal of Plastic Surgery: Official Publication of the Association of Plastic Surgeons of India
https://www.readbyqxmd.com/read/29928086/immediate-breast-reconstruction-with-a-modified-fleur-de-lis-abdominal-free-flap-in-a-patient-with-previous-abdominal-surgery
#4
Manuel Robustillo, Luis Parra Pont, Georgios Pafitanis, Pedro Ciudad, Daniel Grandes, Israel Iglesias
DIEP flap has become the gold standard method for patients undergoing autologous breast reconstruction; however, previous surgery or scars in the abdominal area have been considered a relative contraindication for the use of abdominal tissue. Longitudinal midline abdominal scars may be specially problematic because of the poor midline crossover of blood and the high risk of necrosis of the distal flap. Patients with small breast may be easily reconstructed with hemi-DIEP flap; however, patients with large breast need more tissue available...
January 2018: Indian Journal of Plastic Surgery: Official Publication of the Association of Plastic Surgeons of India
https://www.readbyqxmd.com/read/29928083/infragluteal-fasciocutaneous-flap-for-management-of-recurrent-ischial-pressure-sore
#5
Umesh Kumar, Pradeep Jain
Objective: The objective of the study was to determine the feasibility of infragluteal fasciocutaneous flap in recurrent ischial pressure sore. Materials and Methods: In our study, from 2015 to 2017, nine patients suffering from recurrent ischial sore with scars of previous surgery were managed with infragluteal fasciocutaneous flap. Wound bed was prepared by surgical debridement and negative pressure wound therapy in each case. In two cases, gracilis muscle flap was used as adjuvant to fill up the residual cavity...
January 2018: Indian Journal of Plastic Surgery: Official Publication of the Association of Plastic Surgeons of India
https://www.readbyqxmd.com/read/29928080/the-reverse-dorsal-metacarpal-artery-flap-in-finger-reconstruction-a-reliable-choice
#6
Jyoshid R Balan, Shaji Mathew, Pradeep Kumar, Harsh Vardhan, Anto Francis, V G Aniljith, Raj Gopal
Background: The finger skin and soft-tissue defects are reconstructive challenges due to their nature and the intricate extensor apparatus and flexors it protects. The reverse dorsal metacarpal artery (RDMA) is a time-tested option for the reconstruction of the same. Materials and Methods: A total of 14 cases of RDMA flap for finger defects involving proximal to distal phalanx were performed. Thirteen of these patients were male and one patient female and the most common mode of injury was occupational in nature followed by road traffic accident...
January 2018: Indian Journal of Plastic Surgery: Official Publication of the Association of Plastic Surgeons of India
https://www.readbyqxmd.com/read/29928078/distal-major-pedicle-of-sartorius-muscle-flap-anatomical-study-and-its-clinical-implications
#7
K N Manjunath, M S Venkatesh, Ashwini Shivaprasad
Background: Reconstruction of the popliteal region has limited option in terms of muscle flaps or myocutaneous flaps. Gastrocnemius muscle or the myocutaneous flaps are the option for majority of cases. However, reach of Gastrocnemius is limited if the wound is on the distal one-third thigh or the lateral aspect of knee region. Similarly, if the wound injures the muscle, then coverage becomes all the more difficult. Although inferiorly based fasciocutaneous flaps can cover the wound in case of bony injuries, muscle flaps are beneficial as they help in fracture healing...
January 2018: Indian Journal of Plastic Surgery: Official Publication of the Association of Plastic Surgeons of India
https://www.readbyqxmd.com/read/29928077/reconstruction-of-type-ii-abdominal-wall-defects-anterolateral-thigh-or-tensor-fascia-lata-myocutaneous-flaps
#8
Jammula S Srinivas, Prakash Panagatla, Mukunda Reddy Damalacheru
Introduction: Reconstruction of complex abdominal wall defects is both challenging and technically demanding for plastic surgeon. Objectives in abdominal wall reconstruction are consistent and include restoration of abdominal wall integrity, protection of intra abdominal viscera and prevention of herniation. Materials: We conducted a retrospective study on five patients in whom lateral thigh flaps such as anterolateral thigh (ALT) flaps and tensor fascia lata (TFL) myocutaneous flaps as pedicled or free flaps were used for complex abdominal wall Type II defects over a 5- years period between 2007 and 2012...
January 2018: Indian Journal of Plastic Surgery: Official Publication of the Association of Plastic Surgeons of India
https://www.readbyqxmd.com/read/29928076/a-retrospective-analysis-of-latissimus-dorsi-serratus-anterior-chimeric-flap-reconstruction-in-47-patients-with-extensive-lower-extremity-trauma
#9
Ravi Kumar Mahajan, Krishnan Srinivasan, Abhiskek Bhamre, Mahipal Singh, Prakash Kumar, Ankush Tambotra
Background: Many flaps have been described for reconstruction of lower extremity defects, including, Latissimus Dorsi, Rectus abdominis, Anterolateral thigh perforator flaps, each having advantages and disadvantages. The defect location, size and specific geometric pattern of defect influences the type of flap that can be used. In this case series, we describe the specific situations where the use of chimeric latissimus dorsi-serratus anterior (LD + SA) free flaps are of advantage in providing complete wound cover...
January 2018: Indian Journal of Plastic Surgery: Official Publication of the Association of Plastic Surgeons of India
https://www.readbyqxmd.com/read/29928064/flap-endonuclease-1-is-involved-in-cccdna-formation-in-the-hepatitis-b-virus
#10
Kouichi Kitamura, Lusheng Que, Miyuki Shimadu, Miki Koura, Yuuki Ishihara, Kousho Wakae, Takashi Nakamura, Koichi Watashi, Takaji Wakita, Masamichi Muramatsu
Hepatitis B virus (HBV) is one of the major etiological pathogens for liver cirrhosis and hepatocellular carcinoma. Chronic HBV infection is a key factor in these severe liver diseases. During infection, HBV forms a nuclear viral episome in the form of covalently closed circular DNA (cccDNA). Current therapies are not able to efficiently eliminate cccDNA from infected hepatocytes. cccDNA is a master template for viral replication that is formed by the conversion of its precursor, relaxed circular DNA (rcDNA)...
June 2018: PLoS Pathogens
https://www.readbyqxmd.com/read/29927833/critical-ischemia-time-perfusion-and-drainage-function-of-vascularized-lymph-nodes
#11
Chin-Yu Yang, Olivia A Ho, Ming-Huei Cheng, Hui-Yi Hsiao
BACKGROUND: Vascularized lymph node transfer is a promising surgical treatment for lymphedema. This study investigates the effect of ischemia on the lymphatic drainage efficiency of vascularized lymph node flaps and the critical ischemia time of lymph nodes. METHODS: Twenty-four lymph nodes containing groin flaps in twelve Sprague-Dawley rats were dissected. Clamping of the vascular pedicle was performed for 0, 1, 3, 5, 6, 7 hours, then each allowed to re-perfuse via the vascular pedicle for one hour...
June 12, 2018: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/29927832/comparison-of-immediate-versus-delayed-deep-inferior-epigastric-artery-perforator-diep-flap-reconstruction-in-women-who-require-post-mastectomy-radiotherapy
#12
Rachel L O'Connell, Rosa Di Micco, Komel Khabra, Anna M Kirby, Paul A Harris, Stuart E James, Kieran Power, Kelvin Wd Ramsey, Jennifer E Rusby
INTRODUCTION: The aim of this study was to investigate aesthetic outcome and patient satisfaction in women who have undergone DIEP reconstruction in the setting of PMRT. Patients who underwent DIEP reconstruction without PMRT were the control group. METHODS: Participants who had undergone DIEP between 9/1/2009-9/1/2014 were recruited, answered the BREAST-Q and underwent 3D surface-imaging. A panel assessed the aesthetic outcome by reviewing these images. RESULTS: 167 women participated...
June 12, 2018: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/29927825/closure-of-oroantral-fistula-with-buccal-fat-pad-flap-and-endoscopic-drainage-of-the-maxillary-sinus
#13
Mosaad Abdel-Aziz, Mohamed Fawaz, Mohamed Kamel, Ahmed Kamel, Talal Aljeraisi
Oroantral fistula (OAF) is a pathologic communication between the oral cavity and the maxillary sinus. It is usually associated with maxillary sinusitis, where drainage of sinus infection is a mandatory step during closure of the fistula. The flap used for closure of OAF should be tension free, broadly based and well vascularized. The aim of this study was to assess the effectiveness of closure of OAF using buccal fat pad (BFP) flap with concomitant endoscopic middle meatal antrostomy for maxillary sinus drainage...
June 20, 2018: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29927821/a-decade-s-experience-a-sound-framework-as-the-foundation-to-nasal-reconstruction
#14
Xiaona Lu, Huan Wang, Jianjun You, Bo Zhang, Yihao Xu, Ruobing Zheng, Le Tian, Fei Fan
The goal of nasal reconstruction surgery is to restore normal nasal shape and function, and its success begins with creating a stable framework. In this article the authors discuss the most advantageous materials for building such a framework and how to design this element to achieve better and more durable outcomes. This is a retrospective study including patients who underwent nasal reconstruction in our rhinoplasty and nasal reconstruction center at a tertiary referral hospital between 2006 and 2016. Data included patient characteristics, defect location, the reason for defect, use of supporting structure, flap, lining, and complications were recorded...
June 20, 2018: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29926133/the-originating-pattern-of-deep-inferior-epigastric-artery-anatomical-study-and-surgical-considerations
#15
Yujin Myung, Bomi Choi, Sang Jun Yim, Bo La Yun, Heeyeon Kwon, Chang Sik Pak, Chanyeong Heo, Jae Hoon Jeong
PURPOSE: Studies focusing on the originating patterns of the deep inferior epigastric artery (DIEA) have not been conducted. Here, we analyzed the vascular anatomy of the DIEA with computed tomographic angiography (CTA) to provide assistance during proximal pedicle dissection of a DIEA-based flap. METHODS: We conducted a retrospective study on patients who had undergone breast reconstruction with the transverse rectus abdominis musculocutaneous flap and the deep inferior epigastric perforator flap from March 2006 to October 2016...
June 20, 2018: Surgical and Radiologic Anatomy: SRA
https://www.readbyqxmd.com/read/29926077/comparison-of-2-year-complication-rates-among-common-techniques-for-postmastectomy-breast-reconstruction
#16
Katelyn G Bennett, Ji Qi, Hyungjin M Kim, Jennifer B Hamill, Andrea L Pusic, Edwin G Wilkins
Importance: In breast reconstruction, it is critical for patients and surgeons to have comprehensive information on the relative risks of the available options. However, previous studies that evaluated complications were limited by single-center designs, inadequate follow-up, and confounding. Objective: To assess 2-year complication rates across common techniques for postmastectomy reconstruction in a multicenter patient population. Design, Setting, and Participants: This longitudinal, multicenter, prospective cohort study conducted from February 1, 2012, through July 31, 2015, took place at the 11 study sites associated with the Mastectomy Reconstruction Outcomes Consortium study...
June 20, 2018: JAMA Surgery
https://www.readbyqxmd.com/read/29924849/escherichia-coli-%C3%AE-clamp-slows-down-dna-polymerase-i-dependent-nick-translation-while-accelerating-ligation
#17
Amit Bhardwaj, Debarghya Ghose, Krishan Gopal Thakur, Dipak Dutta
The nick translation property of DNA polymerase I (Pol I) ensures the maturation of Okazaki fragments by removing primer RNAs and facilitating ligation. However, prolonged nick translation traversing downstream DNA is an energy wasting futile process, as Pol I simultaneously polymerizes and depolymerizes at the nick sites utilizing energy-rich dNTPs. Using an in vitro assay system, we demonstrate that the β-clamp of the Escherichia coli replisome strongly inhibits nick translation on the DNA substrate. To do so, β-clamp inhibits the strand displacement activity of Pol I by interfering with the interaction between the finger subdomain of Pol I and the downstream primer-template junction...
2018: PloS One
https://www.readbyqxmd.com/read/29924764/complications-after-superficial-parotidectomy-for-pleomorphic-adenoma
#18
P Infante-Cossio, E Gonzalez-Cardero, A Garcia-Perla-Garcia, E Montes-Latorre, J-L Gutierrez-Perez, E Prats-Golczer
BACKGROUND: The significance of complications after superficial parotidectomy remains unclear, since prospective studies are lacking. The aim of this study was to evaluate facial nerve dysfunction and other postoperative complications after superficial parotidectomy for pleomorphic adenoma of the superficial lobe and to identify the associated risk factors. MATERIAL AND METHODS: Prospective and descriptive clinical study on 79 patients undergoing formal superficial parotidectomy with the modified facelift incision, dissection of the facial nerve and reconstruction with the superficial musculoaponeurotic system flap...
June 20, 2018: Medicina Oral, Patología Oral y Cirugía Bucal
https://www.readbyqxmd.com/read/29924670/simultaneous-robotic-assisted-laparoscopy-for-bladder-and-bowel-reconstruction
#19
Devin R Halleran, Richard J Wood, Alejandra Vilanova-Sanchez, Rebecca M Rentea, Christopher Brown, Molly Fuchs, Venkata R Jayanthi, Christina Ching, Hira Ahmad, Alessandra C Gasior, Marc P Michalsky, Marc A Levitt, Daniel DaJusta
INTRODUCTION: Patients with neurogenic bladder frequently also have bowel dysfunction and a simultaneous urologic and colorectal reconstruction is possible. We present our experience with combined reconstructive procedures using robot-assisted laparoscopy, and demonstrate the utility of a minimally invasive approach that considers both the bowel and bladder management of these patients. METHODS: We retrospectively reviewed all patients who underwent combined bowel and urologic reconstruction at our institution since the start of our multidisciplinary robotic program...
June 20, 2018: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://www.readbyqxmd.com/read/29924215/recurrent-skin-ulcer-cross-repair-and-sensory-reconstruction-in-a-wrn-gene-mutational-patient
#20
Jiqiang He, Ding Pan, Panfeng Wu, Juyu Tang
A 37-year-old man complained of a refractory posterior malleolar ulceration on his left ankle. He was diagnosed with Werner syndrome according to the progeroid clinical features and genetic testing. To approach the ulceration, a free flow-through right anterolateral thigh perforator flap with anterolateral thigh cutaneous nerve was harvested. One year later, he was readmitted due to a new ulceration on his right ankle. We harvested the left anterolateral thigh perforator flap with anterolateral thigh cutaneous nerve to reconstruct the defect...
June 2018: Anais Brasileiros de Dermatologia
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