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https://www.readbyqxmd.com/read/28720784/snap-tagged-chikungunya-virus-replicons-improve-visualisation-of-non-structural-protein-3-by-fluorescence-microscopy
#1
Roland Remenyi, Grace C Roberts, Carsten Zothner, Andres Merits, Mark Harris
Chikungunya virus (CHIKV), a mosquito-borne alphavirus, causes febrile disease, muscle and joint pain, which can become chronic in some individuals. The non-structural protein 3 (nsP3) plays essential roles during infection, but a complete understanding of its function is lacking. Here we used a microscopy-based approach to image CHIKV nsP3 inside human cells. The SNAP system consists of a self-labelling enzyme tag, which catalyses the covalent linking of exogenously supplemented synthetic ligands. Genetic insertion of this tag resulted in viable replicons and specific labelling while preserving the effect of nsP3 on stress granule responses and co-localisation with GTPase Activating Protein (SH3 domain) Binding Proteins (G3BPs)...
July 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28720606/re-using-blood-products-as-an-alternative-supplement-in-the-optimisation-of-clinical-grade-adipose-derived-mesenchymal-stem-cell-culture
#2
J Phetfong, T Tawonsawatruk, K Seenprachawong, A Srisarin, C Isarankura-Na-Ayudhya, A Supokawej
OBJECTIVES: Adipose-derived mesenchymal stem cells (ADMSCs) are a promising strategy for orthopaedic applications, particularly in bone repair. Ex vivo expansion of ADMSCs is required to obtain sufficient cell numbers. Xenogenic supplements should be avoided in order to minimise the risk of infections and immunological reactions. Human platelet lysate and human plasma may be an excellent material source for ADMSC expansion. In the present study, use of blood products after their recommended transfusion date to prepare human platelet lysate (HPL) and human plasma (Hplasma) was evaluated for in vitro culture expansion and osteogenesis of ADMSCs...
July 2017: Bone & Joint Research
https://www.readbyqxmd.com/read/28719806/effect-of-cage-design-supplemental-posterior-instrumentation-and-approach-on-primary-stability-of-a-lumbar-interbody-fusion-a-biomechanical-in-vitro-study
#3
Werner Schmoelz, Sabrina Sandriesser, Oded Loebl, Marlies Bauer, Dietmar Krappinger
BACKGROUND: There are various techniques and approaches for lumbar interbody fusion differing in access, cage type and type of supplemental posterior instrumentation. While a transforaminal access usually includes a hemifacetectomy, the facet joint can be preserved with a more lateral extraforaminal access. The supplemental posterior instrumentation required for both fusion techniques is still debated. The purpose of the present study was to compare primary stability of the two accesses for two different cage types with none, unilateral and bilateral supplemental posterior instrumentation...
July 8, 2017: Clinical Biomechanics
https://www.readbyqxmd.com/read/28717958/-the-8th-edition-of-the-ajcc-cancer-staging-manual-updates-in-otorhinolaryngology-head-and-neck-surgery
#4
REVIEW
J Doescher, J A Veit, T K Hoffmann
BACKGROUND: The TNM system is an established tool for classification of solid tumors by means of tumor size and extent, the involvement of local lymph nodes, and the presence of distant metastases. The classification was established in order to visualize prognostic implications and to allow establishment of systematic therapeutic algorithms. Since the beginning of 2017 a revised version of the classification has applied. Particularly the classification of otorhinolaryngologic tumors has been thoroughly revised in the 8th edition, partly on the basis of new prognostically relevant parameters, such as infection with oncogenic human papillomavirus (HPV) subtypes...
July 17, 2017: HNO
https://www.readbyqxmd.com/read/28707517/joint-effect-of-triclosan-and-copper-nanoparticles-on-wastewater-biological-nutrient-removal
#5
Hong Chen, Yuying Cheng, Di Meng, Gang Xue, Mingji Jiang, Xiang Li
Triclosan (TCS) is widely used in household and personal care products, and its release to wastewater might have impact on wastewater biological treatment due to its broad-spectrum antibacterial property. In addition, emerging pollutant such as copper nanoparticles (CuNPs) will release as well from nanoparticle-containing products, and show joint effect with TCS on biological nutrient removal. It was found that TCS of 1 mg/L and 10 mg/L could inhibit the nitrosification and nitrification stage, and the first step of denitrification was supressed as well, resulting in the final total nitrogen removal efficiency decline...
July 14, 2017: Environmental Technology
https://www.readbyqxmd.com/read/28690952/targeted-radiofrequency-ablation-as-an-adjunct-in-treatment-of-lumbar-facet-cysts
#6
Jesse Hatgis, Michelle Granville, Aldo Berti, Robert E Jacobson
Lumbar facet cysts are frequently found in patients with facet degeneration and segmental instability. When the facet cyst is localized in the neural foramina and lateral recess or becomes large, it can cause radiculopathy or neurogenic claudication. These symptomatic cysts are typically treated interventionally with drainage and a corticosteroid injection or attempts via overinflation to rupture the cyst; however, these procedures have a significant recurrence rate (up to 50%) and often need to be repeated or lead to lumbar surgery if unsuccessful...
June 6, 2017: Curēus
https://www.readbyqxmd.com/read/28689431/what-is-known-about-the-psychodermatology-clinic-model-of-care-a-systematic-scoping-review
#7
Stephanie Zhou, Ilya Mukovozov, An-Wen Chan
BACKGROUND: Psychodermatology focuses on the interaction between skin and mental health. Existing research discusses the recognition and treatment of these disorders. However, little is known about the operational structure of subspecialised psychodermatology clinics. OBJECTIVE: To identify literature on the structure and logistics of delivering a psychodermatology service. METHODS: A systematic search of MEDLINE, PsycINFO, Embase, and Google Scholar was performed...
July 1, 2017: Journal of Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/28688664/a-novel-flight-surgeon-training-model-at-a-joint-military-and-civilian-surgical-residency-program
#8
Erik S DeSoucy, Scott A Zakaluzny, Joseph M Galante
BACKGROUND: Graduating military preliminary interns are often required to fill flight surgeon billets. General surgery preliminary interns get experience evaluating surgical and trauma patients, but receive very little training in primary care and flight medicine. At a joint military and civilian training program, we developed a supplemental curriculum to help transition our interns into flight medicine. METHODS: From 2013 to 2016, we developed a lecture series focused on aerospace medicine, primary care, and specialty topics including dermatology, ophthalmology, orthopedics, pediatrics, psychiatry, and women's health...
July 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/28683124/hybrid-spectral-ct-reconstruction
#9
Darin P Clark, Cristian T Badea
Current photon counting x-ray detector (PCD) technology faces limitations associated with spectral fidelity and photon starvation. One strategy for addressing these limitations is to supplement PCD data with high-resolution, low-noise data acquired with an energy-integrating detector (EID). In this work, we propose an iterative, hybrid reconstruction technique which combines the spectral properties of PCD data with the resolution and signal-to-noise characteristics of EID data. Our hybrid reconstruction technique is based on an algebraic model of data fidelity which substitutes the EID data into the data fidelity term associated with the PCD reconstruction, resulting in a joint reconstruction problem...
2017: PloS One
https://www.readbyqxmd.com/read/28674255/amelioration-of-the-development-of-osteoarthritis-by-daily-intake-of-%C3%AE-cryptoxanthin
#10
Gyujin Park, Tetsuhiro Horie, Kazuya Fukasawa, Kakeru Ozaki, Yuki Onishi, Takashi Kanayama, Takashi Iezaki, Katsuyuki Kaneda, Minoru Sugiura, Eiichi Hinoi
β-Cryptoxanthin, which is primarily obtained from citrus fruits such as Satsuma mandarins, is a major carotenoid routinely found in human serum. Recently, we demonstrated that daily oral intake of β-cryptoxanthin prevented ovariectomy-induced bone loss and ameliorated neuropathic pain in mice. Although β-cryptoxanthin exerts preventive effects on various lifestyle-related diseases, there have been no studies on the effect of β-cryptoxanthin on the development of osteoarthritis, the most common degenerative joint disease, which frequently leads to loss of ability and stiffness in the elderly...
2017: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28672901/evaluation-of-the-effect-of-salmon-nasal-proteoglycan-on-biomarkers-for-cartilage-metabolism-in-individuals-with-knee-joint-discomfort-a-randomized-double-blind-placebo-controlled-clinical-study
#11
Akihito Tomonaga, Tatsuji Takahashi, Yuka Tsuda Tanaka, Makoto Tsuboi, Kumie Ito, Isao Nagaoka
A randomized double-blind placebo-controlled clinical trial was conducted to evaluate the chondroprotective action of salmon nasal cartilage proteoglycan on joint health. The effect of oral administration of proteoglycan (10 mg/day) on cartilage metabolism was evaluated in individuals with knee joint discomfort but without diagnosis of knee osteoarthritis. The average age of patients was 52.6±1.1 years old. The effect of proteoglycan was evaluated by analyzing markers for type II collagen degradation (C1,2C) and synthesis (PIICP), and the ratio of type II collagen degradation to synthesis...
July 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28666499/concurrence-of-torus-palatinus-torus-mandibularis-and-buccal-exostosis
#12
Sarfaraz Khan, Syed Asif Haider Shah, Farman Ali, Dil Rasheed
Torus palatinus (TP), torus mandibularis (TM), and buccal exostosis are localised, benign, osseous projections, occurring in maxilla and mandible. Etiology is multifactorial and not well established. Tori and exostoses have been associated with parafunctional occlusal habits, temporomandibular joint (TMJ) disorders, migraine and consumption of fish. Concurrence of TP, TM, and exostosis in the same individual is very rare. Concurrence of TPand TM has not been reported from Pakistan. We report a case of a 22-year female patient manifesting concurrence of TP, bilateral TM, and maxillary buccal exostoses; with possible association of abnormal occlusal stresses and use of calcium and vitamin D supplements...
November 2016: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/28665876/adolescents-young-people-and-the-90-90-90-goals-a-call-to-improve-hiv-testing-and-linkage-to-treatment
#13
Vincent J Wong, Kate R Murray, B Ryan Phelps, Sten H Vermund, Donna R McCarraher
: The current low rates of HIV diagnosis and treatment initiation among adolescents and young people ages 15-24 continues to present a significant challenge to the epidemic control of HIV. With a 'business as usual' approach to HIV testing and linkage to treatment, new infections among adolescents and youth will likely increase, with the burden compounded by the increasing number of youth in Africa, expected to reach 293 million by 2025. Recent studies reveal significant gaps in the HIV clinical cascade among young people as the global community pursues the Joint United Nations Programme on HIV and AIDS 90-90-90 targets...
July 1, 2017: AIDS
https://www.readbyqxmd.com/read/28665646/editorial-supplemental-material-or-joint-submission
#14
Pierre Meystre
No abstract text is available yet for this article.
June 16, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28665279/modified-methods-for-efficiently-differentiating-human-embryonic-stem-cells-into-chondrocyte-like-cells
#15
Wiktoria Maria Suchorska, Ewelina Augustyniak, Magdalena Richter, Magdalena Łukjanow, Violetta Filas, Jacek Kaczmarczyk, Tomasz Trzeciak
INTRODUCTION: Human articular cartilage has a poor regenerative capacity. This often results in the serious joint disease- osteoarthritis (OA) that is characterized by cartilage degradation. An inability to self-repair provided extensive studies on AC regeneration. The cell-based cartilage tissue engineering is a promising approach for cartilage regeneration. So far, numerous cell types have been reported to show chondrogenic potential, among others human embryonic stem cells (hESCs)...
June 19, 2017: Postȩpy Higieny i Medycyny Doświadczalnej
https://www.readbyqxmd.com/read/28661926/the-discriminative-values-of-the-bath-ankylosing-spondylitis-disease-activity-index-ankylosing-spondylitis-disease-activity-score-c-reactive-protein-and-erythrocyte-sedimentation-rate-in-spondyloarthritis-related-axial-arthritis
#16
Helen Hoi Lun Tsang, Ho Yin Chung
OBJECTIVES: The aims of this study were to determine the effectiveness of Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), Ankylosing Spondylitis Disease Activity Score-C-Reactive Protein (ASDAS-CRP), Ankylosing Spondylitis Disease Activity Score-Erythrocyte Sedimentation Rate (ASDAS-ESR), and inflammatory markers in screening for axial-joint inflammation as detected by magnetic resonance imaging (MRI) and to find out factors that could affect scoring of the indices. METHODS: One hundred fifty-three Chinese spondyloarthritis patients were recruited...
June 29, 2017: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
https://www.readbyqxmd.com/read/28644913/supplement-2-for-the-2004-update-of-the-aapm-task-group-no-43-report-joint-recommendations-by-the-aapm-and-gec-estro
#17
Mark J Rivard, Facundo Ballester, Wayne M Butler, Larry A DeWerd, Geoffrey S Ibbott, Ali S Meigooni, Christopher S Melhus, Michael G Mitch, Ravinder Nath, Panagiotis Papagiannis
Since publication of the 2004 update to the American Association of Physicists in Medicine (AAPM) Task Group No. 43 Report (TG-43U1) and its 2007 supplement (TG-43U1S1), several new low-energy photon-emitting brachytherapy sources have become available. Many of these sources have satisfied the AAPM prerequisites for routine clinical purposes and are posted on the Brachytherapy Seed Registry managed jointly by the AAPM and the Imaging and Radiation Oncology Core Houston Quality Assurance Center (IROC Houston)...
June 23, 2017: Medical Physics
https://www.readbyqxmd.com/read/28635116/maternal-smoking-alcohol-and-caffeine-exposures-and-risk-of-hypospadias
#18
Suzan L Carmichael, Chen Ma, Gary M Shaw
BACKGROUND: We examined the association of hypospadias risk with maternal smoking and consumption of alcohol and caffeine. METHODS: We analyzed data from mothers of 2437 moderate/severe cases and 5472 nonmalformed controls born from 1997 to 2011 who participated in the National Birth Defects Prevention Study (NBDPS). Exposures were assessed by maternal telephone interviews. Logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (95% CIs) adjusted for mother's age, parity, race-ethnicity, education, vitamin/mineral supplement intake, obesity, and study center...
June 21, 2017: Birth defects research
https://www.readbyqxmd.com/read/28628054/personal-and-workplace-environmental-factors-associated-with-reduced-worker-productivity-among-older-workers-with-chronic-knee-pain-a-cross-sectional-survey
#19
Maria Agaliotis, Martin G Mackey, Robert Heard, Stephen Jan, Marlene Fransen
OBJECTIVES: The aim of this study was to explore personal and workplace environmental factors as predictors of reduced worker productivity among older workers with chronic knee pain. METHODS: A questionnaire-based survey was conducted among 129 older workers who had participated in a randomized clinical trial evaluating dietary supplements. Multivariable analyses were used to explore predictors of reduced work productivity among older workers with chronic knee pain...
April 2017: Journal of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/28611391/isothiocyanates-are-detected-in-human-synovial-fluid-following-broccoli-consumption-and-can-affect-the-tissues-of-the-knee-joint
#20
Rose Davidson, Sarah Gardner, Orla Jupp, Angela Bullough, Sue Butters, Laura Watts, Simon Donell, Maria Traka, Shikha Saha, Richard Mithen, Mandy Peffers, Peter Clegg, Yongping Bao, Aedin Cassidy, Ian Clark
Osteoarthritis is a major cause of disability and there is no current pharmaceutical treatment which can prevent the disease or slow its progression. Dietary advice or supplementation is clearly an attractive option since it has low toxicity and ease of implementation on a population level. We have previously demonstrated that sulforaphane, a dietary isothiocyanate derived from its glucosinolate precursor which is found in broccoli, can prevent cartilage destruction in cells, in in vitro and in vivo models of osteoarthritis...
June 13, 2017: Scientific Reports
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