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https://www.readbyqxmd.com/read/27898233/hyaluronan-stimulates-chondrogenic-gene-expression-in-human-meniscus-cells
#1
Takaaki Tanaka, Takayuki Furumatsu, Shinichi Miyazawa, Masataka Fujii, Hiroto Inoue, Yuya Kodama, Toshifumi Ozaki
: Purpose/Aim of the Study: Inner meniscus cells have a chondrocytic phenotype, whereas outer meniscus cells have a fibroblastic phenotype. In this study, we examined the effect of hyaluronan on chondrocytic gene expression in human meniscus cells. MATERIALS AND METHODS: Human meniscus cells were prepared from macroscopically intact lateral meniscus. Inner and outer meniscus cells were obtained from the inner and outer halves of the meniscus. The cells were stimulated with hyaluronan diluted in Dulbecco's modified Eagle's medium without serum to the desired concentration (0, 10, 100, and 1000 μg/mL) for 2-7 days...
November 29, 2016: Connective Tissue Research
https://www.readbyqxmd.com/read/27876676/anatomical-region-dependent-enhancement-of-3-dimensional-chondrogenic-differentiation-of-human-mesenchymal-stem-cells-by-soluble-meniscus-extracellular-matrix
#2
Benjamin B Rothrauff, Kazunori Shimomura, Riccardo Gottardi, Peter G Alexander, Rocky S Tuan
: Extracellular matrix (ECM) derived from decellularized tissues has been found to promote tissue neogenesis, most likely mediated by specific biochemical and physical signaling motifs that promote tissue-specific differentiation of progenitor cells. Decellularized ECM has been suggested to be efficacious for the repair of tissue injuries. However, decellularized meniscus contains a dense collagenous structure, which impedes cell seeding and infiltration and is not readily applicable for meniscus repair...
November 19, 2016: Acta Biomaterialia
https://www.readbyqxmd.com/read/27783214/selenium-reduces-early-signs-of-tumor-necrosis-factor-alpha-induced-meniscal-tissue-degradation
#3
Klaus Häfelein, Andrea Preuße-Prange, Peter Behrendt, Bodo Kurz
Meniscal integrity is a prerequisite for sustained knee joint health and prevention of meniscal degeneration is a main research goal. Cartilage-protective effects of selenium have been described, but little is known about the impact on the meniscus. We therefore investigated the influence of sodium selenite on meniscal explants under tumor necrosis factor-alpha (TNFα)-stimulated proinflammatory conditions. Meniscal explant disks (3 mm diameter × 1 mm thickness) were isolated from 2-year-old cattle and incubated with TNFα (10 ng/ml) and sodium selenite (low dose, LoD 6...
October 25, 2016: Biological Trace Element Research
https://www.readbyqxmd.com/read/27729320/overlap-between-anterior-cruciate-ligament-and-anterolateral-meniscal-root-insertions-a-scanning-electron-microscopy-study
#4
Brett D Steineman, Samuel G Moulton, Tammy L Haut Donahue, Cristián A Fontboté, Christopher M LaPrade, Tyler R Cram, Chase S Dean, Robert F LaPrade
BACKGROUND: The anterolateral meniscal root (ALMR) has been reported to intricately insert underneath the tibial insertion of the anterior cruciate ligament (ACL). Previous studies have begun to evaluate the relationship between the insertion areas and the risk of iatrogenic injuries; however, the overlap of the insertions has yet to be quantified in the sagittal and coronal planes. PURPOSE: To investigate the insertions of the human tibial ACL and ALMR using scanning electron microscopy (SEM) and to quantify the overlap of the ALMR insertion in the coronal and sagittal planes...
October 11, 2016: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/27697006/meniscal-surgery-risk-of-radiographic-joint-space-narrowing-progression-and-subsequent-knee-replacement-data-from-the-osteoarthritis-initiative
#5
Bashir Zikria, Nima Hafezi-Nejad, Frank W Roemer, Ali Guermazi, Shadpour Demehri
Purpose To investigate the risk of radiographic joint space narrowing (JSN) progression evaluated in subjects with and those without underlying osteoarthritis at baseline and knee replacement (KR) associated with meniscal surgery in subjects with and those without a reported history of preceding knee trauma. Materials and Methods The HIPAA-compliant protocol was approved by the institutional review boards of the participating centers. Written informed consent was obtained from all participants. Subjects who underwent meniscal surgery with a preceding knee trauma at baseline (n = 564) and those without (n = 147) were drawn from the Osteoarthritis Initiative cohort (n = 4796)...
October 3, 2016: Radiology
https://www.readbyqxmd.com/read/27638845/structural-pathology-is-not-related-to-patient-reported-pain-and-function-in-patients-undergoing-meniscal-surgery
#6
Simon Maretti Tornbjerg, Nis Nissen, Martin Englund, Uffe Jørgensen, Jeppe Schjerning, L Stefan Lohmander, Jonas Bloch Thorlund
BACKGROUND: The relationship between meniscal tears and other joint pathologies with patient-reported symptoms is not clear. We investigated associations between structural knee pathologies identified at surgery with preoperative knee pain and function in patients undergoing arthroscopic meniscal surgery. METHODS: This study included 443 patients from the Knee Arthroscopy Cohort Southern Denmark (KACS), a prospective cohort following patients 18 years or older undergoing arthroscopic meniscal surgery at 4 hospitals between 1 February 2013 and 31 January 2014...
September 16, 2016: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/27141865/paediatric-acl-repair-reinforced-with-temporary-internal-bracing
#7
James O Smith, Sam K Yasen, Harry C Palmer, Breck R Lord, Edward M Britton, Adrian J Wilson
PURPOSE: Instability following non-operative treatment of anterior cruciate ligament (ACL) rupture in young children frequently results in secondary chondral and/or meniscal injuries. Therefore, many contemporary surgeons advocate ACL reconstruction in these patients, despite the challenges posed by peri-articular physes and the high early failure rate. We report a novel management approach, comprising direct ACL repair reinforced by a temporary internal brace in three children. METHODS: Two patients (aged 5 and 6 years) with complete proximal ACL ruptures and a third (aged seven) with an associated tibial spine avulsion underwent direct surgical repair, supplemented with an internal brace that was removed after 3 months...
June 2016: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/27041085/probing-the-relation-between-vitamin-d-deficiency-and-progression-of-medial-femoro-tibial-osteoarthitis-of-the-knee
#8
Hassan Bassiouni, Hany Aly, Khaled Zaky, Nouran Abaza, Thomas Bardin
OBJECTIVE: To compare serum 25 OH vitamin D (25 (OH) D) levels between medial femoro-tibial knee osteoarthritis (OA) patients and controls, and to detect structural progression in patients with mild to moderate knee osteoarthritis in relation to baseline 25(OH) D levels in a one-year longitudinal prospective cohort study. METHODS: Thirty eight patients with medial femoro-tibial knee OA according to the ACR criteria and no knee malalignement, and 20 age, sex and BMI-matched pain free controls were included in the vitamin D study...
April 4, 2016: Current Rheumatology Reviews
https://www.readbyqxmd.com/read/27039684/editorial-commentary-how-to-achieve-accurate-graft-placement-in-lateral-meniscal-allograft-transplantation
#9
EDITORIAL
Shinichi Yoshiya
The lateral tibial spine may not be a reliable reference for determining the direction of the guide pin for the keyhole in the lateral meniscal allograft transplantation procedure. Supplemental landmarks may be required to improve the accuracy in graft placement.
April 2016: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/26895663/daily-sesame-oil-supplement-attenuates-joint-pain-by-inhibiting-muscular-oxidative-stress-in-osteoarthritis-rat-model
#10
Dur-Zong Hsu, Pei-Yi Chu, I-Ming Jou
Osteoarthritis (OA) is the most common form of arthritis, affecting approximately 15% of the population. The aim of this study was to evaluate the efficacy of sesame oil in controlling OA pain in rats. Rat joint pain was induced by medial meniscal transection in Sprague-Dawley rats and assessed by using hindlimb weight distribution method. Muscular oxidative stress was assessed by determining lipid peroxidation, reactive oxygen species and circulating antioxidants. Sesame oil significantly decreased joint pain compared with positive control group in a dose-dependent manner...
March 2016: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/26511364/a-combination-of-biomolecules-enhances-expression-of-e-cadherin-and-peroxisome-proliferator-activated-receptor-gene-leading-to-increased-cell-proliferation-in-primary-human-meniscal-cells-an-in-vitro-study
#11
Mamatha M Pillai, V Elakkiya, J Gopinathan, C Sabarinath, S Shanthakumari, K Santosh Sahanand, B K Dinakar Rai, Amitava Bhattacharyya, R Selvakumar
The present study investigates the impact of biomolecules (biotin, glucose, chondroitin sulphate, proline) as supplement, (individual and in combination) on primary human meniscus cell proliferation. Primary human meniscus cells isolated from patients undergoing meniscectomy were maintained in Dulbecco's Modified Eagle's Medium (DMEM). The isolated cells were treated with above mentioned biomolecules as individual (0-100 µg/ml) and in combinations, as a supplement to DMEM. Based on the individual biomolecule study, a unique combination of biomolecules (UCM) was finalized using one way ANOVA analysis...
October 2016: Cytotechnology
https://www.readbyqxmd.com/read/25917638/meniscus-is-more-susceptible-than-cartilage-to-catabolic-and-anti-anabolic-effects-of-adipokines
#12
J F Nishimuta, M E Levenston
OBJECTIVE: This study compared the effects on cartilage and meniscus matrix catabolism and biosynthesis of several adipokines implicated in osteoarthritis (OA). DESIGN: Bovine cartilage and meniscus explants were cultured for 1 or 9 days in serum-free medium alone or with 0.02, 0.2, or 2 μg/ml of leptin, visfatin, adiponectin, or resistin. Media were supplemented with (3)H-proline or (35)S-sodium sulfate to evaluate protein and sulfated glycosaminoglycan (sGAG) accumulation on the last day of culture...
September 2015: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/25490015/radiofrequency-stimulation-for-potential-healing-of-meniscal-injuries-in-the-avascular-zone
#13
Christopher S Lee, James P Tasto, Robert M Healey, Sakae Sano, David Amiel
We conducted this study to evaluate the effect of radiofrequency (RF) stimulation with suture repair on the healing of tears in the meniscal white-white zone. Fifty-four New Zealand white rabbits underwent surgically induced meniscal injuries within the white-white region. RF was applied using a 0.8-mm TOPAZ MicroDebrider RF wand (ArthroCare) at level 4 for 500 milliseconds. Rabbits were sacrificed at 28 and 84 days for gross and histologic analysis by 3 blinded observers and at 9, 28, and 84 days for biochemical examination...
December 2014: American Journal of Orthopedics
https://www.readbyqxmd.com/read/25307081/endothelial-cells-enhance-the-migration-of-bovine-meniscus-cells
#14
Xiaoning Yuan, George M Eng, Derya E Arkonac, Pen-Hsiu Grace Chao, Gordana Vunjak-Novakovic
OBJECTIVE: To study the interactions between vascular endothelial cells and meniscal fibrochondrocytes from the inner avascular and outer vascular regions of the meniscus and to identify angiogenic factors that enhance cell migration and integrative repair. METHODS: Bovine meniscal fibrochondrocytes (bMFCs) from the inner and outer regions of meniscus were cultured for 7 days with or without human umbilical vein endothelial cells (HUVECs) in a micropatterned 3-dimensional hydrogel system for assessment of cell migration...
January 2015: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/25106782/anatomy-of-the-anterior-root-attachments-of-the-medial-and-lateral-menisci-a-quantitative-analysis
#15
Christopher M LaPrade, Michael B Ellman, Matthew T Rasmussen, Evan W James, Coen A Wijdicks, Lars Engebretsen, Robert F LaPrade
BACKGROUND: While the biomechanical importance of the meniscal roots has been demonstrated, the anatomy of the anterior meniscal roots remains largely unknown. Defining the quantitative anatomy of the anterior meniscal root attachments is essential for developing improved diagnostic and surgical techniques. HYPOTHESIS: The anterior medial (AM) and anterior lateral (AL) meniscal roots could be quantitatively defined relative to open and arthroscopic surgical landmarks...
October 2014: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/25019436/mr-imaging-based-diagnosis-and-classification-of-meniscal-tears
#16
Jie C Nguyen, Arthur A De Smet, Ben K Graf, Humberto G Rosas
Magnetic resonance (MR) imaging is currently the modality of choice for detecting meniscal injuries and planning subsequent treatment. A thorough understanding of the imaging protocols, normal meniscal anatomy, surrounding anatomic structures, and anatomic variants and pitfalls is critical to ensure diagnostic accuracy and prevent unnecessary surgery. High-spatial-resolution imaging of the meniscus can be performed using fast spin-echo and three-dimensional MR imaging sequences. Normal anatomic structures that can mimic a tear include the meniscal ligament, meniscofemoral ligaments, popliteomeniscal fascicles, and meniscomeniscal ligament...
July 2014: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/24888224/repair-of-a-complete-radial-tear-in-the-midbody-of-the-medial-meniscus-using-a-novel-crisscross-suture-transtibial-tunnel-surgical-technique-a-case-report
#17
Evan W James, Christopher M LaPrade, John A Feagin, Robert F LaPrade
Complete radial meniscus tears have been reported to result in deleterious effects in the knee joint if left unrepaired. An emphasis on meniscal preservation is important in order to restore native meniscal function. In this case report, a complete radial tear of the medial meniscus midbody was repaired using a novel crisscross suture transtibial technique. This technique secured the anterior and posterior meniscal horns, which were released from their extruded and scarred position along the capsule, using crisscrossing sutures passed through two transtibial tunnels and secured over a bone bridge on the anterolateral tibia...
September 2015: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/24799425/structural-properties-of-the-meniscal-roots
#18
Michael B Ellman, Christopher M LaPrade, Sean D Smith, Matthew T Rasmussen, Lars Engebretsen, Coen A Wijdicks, Robert F LaPrade
BACKGROUND: Current surgical techniques for meniscal root repair reattach the most prominent, dense portion of the meniscal root and fail to incorporate recently identified peripheral, supplemental attachment fibers. The contribution of supplemental fibers to the biomechanical properties of native meniscal roots is unknown. HYPOTHESIS/PURPOSE: The purpose was to quantify the ultimate failure strengths, stiffness, and attachment areas of the native posterior medial (PM), posterior lateral (PL), anterior medial (AM), and anterior lateral (AL) meniscal roots compared with the most prominent, dense meniscal root attachment after sectioning of supplemental fibers...
August 2014: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/24330551/matrix-forming-characteristics-of-inner-and-outer-human-meniscus-cells-on-3d-collagen-scaffolds-under-normal-and-low-oxygen-tensions
#19
Roger Croutze, Nadr Jomha, Hasan Uludag, Adetola Adesida
BACKGROUND: Limited intrinsic healing potential of the meniscus and a strong correlation between meniscal injury and osteoarthritis have prompted investigation of surgical repair options, including the implantation of functional bioengineered constructs. Cell-based constructs appear promising, however the generation of meniscal constructs is complicated by the presence of diverse cell populations within this heterogeneous tissue and gaps in the information concerning their response to manipulation of oxygen tension during cell culture...
2013: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/24210471/enhanced-boundary-lubrication-properties-of-engineered-menisci-by-lubricin-localization-with-insulin-like-growth-factor-i-treatment
#20
Edward D Bonnevie, Jennifer L Puetzer, Lawrence J Bonassar
In this study we analyzed the effects of IGF-I on the boundary lubricating ability of engineered meniscal tissue using a high density collagen gel seeded with meniscal fibrochondrocytes. Biochemical, histological, immunohistochemical, and tribological analyses were carried out to determine a construct's ability to functionally localize lubricin. Our study revealed that supplementation with IGF-I enhanced both the proliferation of cells within the construct as well as enhanced the anabolic activity of the seeded cells...
June 27, 2014: Journal of Biomechanics
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