keyword
MENU ▼
Read by QxMD icon Read
search

Diabetes type 1 rct

keyword
https://www.readbyqxmd.com/read/28718236/dose-comparison-and-side-effect-profile-of-metformin-extended-release-versus-metformin-immediate-release
#1
Maliha Hameed, Khurshid Khan, Sadia Salman, Nasir Mehmood
BACKGROUND: Diabetes Mellitus type 2 is very common worldwide, with majority of cases in Asia Pacific region. Metformin is the first line therapy, along with lifestyle modification for all type 2 diabetics as recommended by ADA. Metformin is available as conventional Metformin Immediate Release (MIR) and Metformin Extended Release (MXR). Metformin XR has better gastrointestinal tolerability and fewer side effects as compared to Metformin IR, with similar efficacy regarding anti-hyperglycaemic effects...
April 2017: Journal of Ayub Medical College, Abbottabad: JAMC
https://www.readbyqxmd.com/read/28716847/nonnutritive-sweeteners-and-cardiometabolic-health-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials-and-prospective-cohort-studies
#2
Meghan B Azad, Ahmed M Abou-Setta, Bhupendrasinh F Chauhan, Rasheda Rabbani, Justin Lys, Leslie Copstein, Amrinder Mann, Maya M Jeyaraman, Ashleigh E Reid, Michelle Fiander, Dylan S MacKay, Jon McGavock, Brandy Wicklow, Ryan Zarychanski
BACKGROUND: Nonnutritive sweeteners, such as aspartame, sucralose and stevioside, are widely consumed, yet their long-term health impact is uncertain. We synthesized evidence from prospective studies to determine whether routine consumption of non-nutritive sweeteners was associated with long-term adverse cardiometabolic effects. METHODS: We searched MEDLINE, Embase and Cochrane Library (inception to January 2016) for randomized controlled trials (RCTs) that evaluated interventions for nonnutritive sweeteners and prospective cohort studies that reported on consumption of non-nutritive sweeteners among adults and adolescents...
July 17, 2017: CMAJ: Canadian Medical Association Journal, Journal de L'Association Medicale Canadienne
https://www.readbyqxmd.com/read/28716522/exercise-individualized-by-trimpi-method-reduces-arterial-stiffness-in-early-onset-type-2-diabetic-patients-a-randomized-controlled-trial-with-aerobic-interval-training
#3
Alfonso Bellia, Ferdinando Iellamo, Elisa De Carli, Aikaterini Andreadi, Elvira Padua, Mauro Lombardo, Giuseppe Annino, Francesca Campoli, Sara Tartaglione, Stefano D'Ottavio, David Della-Morte, Davide Lauro
BACKGROUND: Arterial stiffness (AS) and baroreflex sensitivity (BRS) are subclinical markers of vascular diseases in type 2 diabetes (T2D). We evaluated the effects of aerobic interval training (AIT), with loads prescribed according to individual heart rate and lactate profiling obtained during a baseline treadmill test (TRIMPi method), on AS and BRS in patients with early-onset T2D without cardiovascular complications. POPULATION STUDY AND METHODS: Twenty-two sedentary overweight T2D patients (aged 57±7years) were randomized to 12-weeks open-label of supervised AIT by TRIMPi (n=8) or unsupervised physical activity as per usual care (SOC) (n=11)...
June 17, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28700718/reduction-of-diabetes-related-distress-predicts-improved-depressive-symptoms-a-secondary-analysis-of-the-diamos-study
#4
André Reimer, Andreas Schmitt, Dominic Ehrmann, Bernhard Kulzer, Norbert Hermanns
OBJECTIVE: Depressive symptoms in people with diabetes are associated with increased risk of adverse outcomes. Although successful psychosocial treatment options are available, little is known about factors that facilitate treatment response for depression in diabetes. This prospective study aims to examine the impact of known risk factors on improvement of depressive symptoms with a special interest in the role of diabetes-related distress. METHODS: 181 people with diabetes participated in a randomized controlled trial...
2017: PloS One
https://www.readbyqxmd.com/read/28695579/exploring-the-evidence-base-for-tier-3-weight-management-interventions-for-adults-a-systematic-review
#5
REVIEW
T J Brown, C O'Malley, J Blackshaw, V Coulton, A Tedstone, C Summerbell, L J Ells
Specialist weight management services provide a treatment option for severe obesity. The objective of the study is to review the characteristics, impact and practice implications of specialist weight management services for adults in the UK. Systematic review: EMBASE, MEDLINE and PsycINFO were searched from January 2005 to March 2016 with supplementary searches. Adults with a body mass index of ≥40 kg m(-2) , or ≥35 kg m(-2) with comorbidity or ≥30 kg m(-2) with type 2 diabetes and any study of multicomponent interventions, in any UK or Ireland setting, delivered by a specialist multidisciplinary team are the inclusion criteria...
July 10, 2017: Clinical Obesity
https://www.readbyqxmd.com/read/28689524/effects-of-supervised-structured-aerobic-exercise-training-program-on-interleukin-6-nitric-oxide-synthase-1-and-cyclooxygenase-2-in-type-2-diabetes-mellitus
#6
Hossein Karimi, Syed Shakil Ur Rehman, Syed Amir Gillani
OBJECTIVE: To determine the effects of supervised structured aerobic exercise training (SSAET) program on interleukin-6 (IL-6), nitric oxide synthase 1 (NOS-1), and cyclooxygenase-2 (COX-2) in type 2 diabetes mellitus (T2DM). STUDY DESIGN: Randomized controlled trial. PLACE AND DURATION OF STUDY: Riphah Rehabilitation and Research Centre, Railways General Hospital, Rawalpindi, from January 2015 to June 2016. METHODOLOGY: Patients of either gender of minimum one year history of T2DM ranging from 40-70 years of age were included...
June 2017: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/28687275/avoidance-of-cow-s-milk-based-formula-for-at-risk-infants-does-not-reduce-development-of-celiac-disease-a-randomized-controlled-trial
#7
Mila Hyytinen, Erkki Savilahti, Suvi M Virtanen, Taina Härkönen, Jorma Ilonen, Kristiina Luopajärvi, Raivo Uibo, Outi Vaarala, Hans K Åkerblom, Mikael Knip
BACKGROUND & AIMS: Feeding during first months of life might affect risk of celiac disease. Individuals with celiac disease or type 1 diabetes have been reported to have high titers of antibodies against cow´s milk proteins. Avoidance of cow's milk-based formula for infants with genetic susceptibility for type 1 diabetes reduced the cumulative incidence of diabetes-associated autoantibodies. We performed a randomized controlled trial, in the same population, to study whether weaning to an extensively hydrolyzed formula reduced the risk of celiac disease autoimmunity or celiac disease...
July 4, 2017: Gastroenterology
https://www.readbyqxmd.com/read/28677892/chromium-supplementation-for-adjuvant-treatment-of-type-2-diabetes-mellitus-results-from-a-pooled-analysis
#8
Haohai Huang, Guangzhao Chen, Yong Dong, Yongkun Zhu, Honglang Chen
SCOPE: We conducted a pooled analysis of randomized controlled trials to evaluate the effects of chromium supplementation on clinically relevant metabolic biomarkers in type 2 diabetes mellitus (T2DM) patients. METHODS AND RESULTS: Electronic searches were conducted and the bibliographies of located articles were searched, and 28 studies were suitable for statistical pooling. Endpoints were calculated as weighted mean differences (WMDs) with 95% confidence intervals (CIs) by using fixed-effects or random-effects models...
July 5, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28672172/baseline-red-blood-cell-distribution-width-predicts-long-term-glycemic-remission-in-patients-with-type-2-diabetes
#9
Lijuan Xu, Liangjiao Wang, Xinwei Huang, Liehua Liu, Weijian Ke, Xiaoying He, Zhimin Huang, Juan Liu, Xuesi Wan, Xiaopei Cao, Yanbing Li
AIMS: We explored whether red blood cell distribution width (RDW), a routinely checked item of complete blood cell counts, was an indicator of long-term euglycemia remission in patients with type 2 diabetes after short-term continuous subcutaneous insulin infusion (CSII). METHODS: We analyzed the original data of patients enrolled in three randomized control trials from 2002 to 2014. CSII was administered to drug-naїve patients with newly diagnosed type 2 diabetes to achieve and maintain euglycemia for 2weeks...
June 15, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28669666/a-randomized-controlled-trial-on-the-efficacy-of-resistant-dextrin-as-functional-food-in-women-with-type-2-diabetes-targeting-the-hypothalamic-pituitary-adrenal-axis-and-immune-system
#10
Mahdieh Abbasalizad Farhangi, Ahmad Zare Javid, Bahareh Sarmadi, Poran Karimi, Parvin Dehghan
OBJECTIVE: The aim of this trial was to determine the efficacy of a resistant dextrin on immune-mediated inflammation and hypothalamic-pituitary-adrenal axis in women with type 2 diabetes mellitus (T2DM). METHODS: Females (n = 55) with T2DM were randomly allocated into intervention group (n = 30) and control group (n = 25), in which they received 10 g/d of Nutriose(®)06 (a resistant dextrin) or maltodextrin for 8 weeks, respectively. Fasting blood samples were taken to measure immune system related parameters like white blood cell count, CD4, CD8, interferon-γ (IFNγ), interleukins (IL12, IL4, IL10), cortisol, tryptophan (TRP), ACTH (Adrenocorticotropic hormone), Kynurenine (KYN) and plasma lipopolysaccharide (LPS) at the beginning and end of trial...
June 10, 2017: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/28663934/effects-of-sodium-glucose-co-transporter-2-sglt2-inhibition-on-renal-function-and-albuminuria-in-patients-with-type-2-diabetes-a-systematic-review-and-meta-analysis
#11
Lubin Xu, Yang Li, Jiaxin Lang, Peng Xia, Xinyu Zhao, Li Wang, Yang Yu, Limeng Chen
AIM: To evaluate the effects of sodium-glucose co-transporter 2 (SGLT2) inhibition on renal function and albuminuria in patients with type 2 diabetes. METHODS: We conducted systematic searches of PubMed, Embase and Cochrane Central Register of Controlled Trials up to June 2016 and included randomized controlled trials of SGLT2 inhibitors in adult type 2 diabetic patients reporting estimated glomerular filtration rate (eGFR) and/or urine albumin/creatinine ratio (ACR) changes...
2017: PeerJ
https://www.readbyqxmd.com/read/28662074/fiber-rich-diet-with-brown-rice-improves-endothelial-function-in-type-2-diabetes-mellitus-a-randomized-controlled-trial
#12
Keiko Kondo, Katsutaro Morino, Yoshihiko Nishio, Atsushi Ishikado, Hisatomi Arima, Keiko Nakao, Fumiyuki Nakagawa, Fumio Nikami, Osamu Sekine, Ken-Ichi Nemoto, Makoto Suwa, Motonobu Matsumoto, Katsuyuki Miura, Taketoshi Makino, Satoshi Ugi, Hiroshi Maegawa
BACKGROUND & AIMS: A fiber-rich diet has a cardioprotective effect, but the mechanism for this remains unclear. We hypothesized that a fiber-rich diet with brown rice improves endothelial function in patients with type 2 diabetes mellitus. METHODS: Twenty-eight patients with type 2 diabetes mellitus at a single general hospital in Japan were randomly assigned to a brown rice (n = 14) or white rice (n = 14) diet and were followed for 8 weeks. The primary outcome was changes in endothelial function determined from flow debt repayment by reactive hyperemia using strain-gauge plethysmography in the fasting state...
2017: PloS One
https://www.readbyqxmd.com/read/28656707/efficacy-and-safety-of-sodium-glucose-cotransporter-2-inhibitors-versus-dipeptidyl-peptidase-4-inhibitors-as-monotherapy-or-add-on-to-metformin-in-patients-with-type-2-diabetes-mellitus-a-systematic-review-and-meta-analysis
#13
Zhiying Wang, Jiahui Sun, Ruobing Han, Dongzhu Fan, Xinyi Dong, Zenghui Luan, Rongwu Xiang, Mingyi Zhao, Jingyu Yang
AIMS: To compare the efficacy and safety of dipeptidyl peptidase-4 inhibitors (DPP-4is) and sodium-glucose cotransporter-2 inhibitors (SGLT-2is) as monotherapy or add-on to metformin (Met) in patients with type 2 diabetes mellitus (T2DM). MATERIALS AND METHODS: PubMed, Embase, and ClinicalTrials.gov were systematically searched for randomized controlled trials to assess the efficacy and safety of DPP-4is and SGLT-2is in patients with T2DM. Risk ratio (RR) and weighted mean difference (WMD) were used to evaluate the outcomes...
June 28, 2017: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/28639706/exercise-for-pregnant-women-with-gestational-diabetes-for-improving-maternal-and-fetal-outcomes
#14
REVIEW
Julie Brown, Gilles Ceysens, Michel Boulvain
BACKGROUND: Gestational diabetes mellitus (GDM) is associated with both short- and long-term complications for the mother and her baby. Exercise interventions may be useful in helping with glycaemic control and improve maternal and infant outcomes.The original review on Exercise for diabetic pregnant women has been split into two new review titles reflecting the role of exercise for pregnant women with gestational diabetes and for pregnant women with pre-existing diabetes. Exercise for pregnant women with gestational diabetes for improving maternal and fetal outcomes (this review) Exercise for pregnant women with pre-existing diabetes for improving maternal and fetal outcomes OBJECTIVES: To evaluate the effects of exercise interventions for improving maternal and fetal outcomes in women with GDM...
June 22, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28638006/effect-of-probiotics-on-glucose-and-lipid-metabolism-in-type-2-diabetes-mellitus-a-meta-analysis-of-12-randomized-controlled-trials
#15
Kecheng Yao, Linghai Zeng, Qian He, Wei Wang, Jiao Lei, Xiulan Zou
BACKGROUND It has been unclear whether supplemental probiotics therapy improves clinical outcomes in type 2 diabetic patients. This meta-analysis aimed to summarize the effect of probiotics on glucose and lipid metabolism and C-reactive protein (CRP) from 12 randomized controlled trials (RCTs). MATERIAL AND METHODS An up-to-date search was performed for all relevant RCTs up to April 2016 from PubMed, Embase, and Cochrane Library. Standardized mean difference (SMD) and weighted mean difference (WMD) were calculated for a fixed-effect and random-effect meta-analysis to assess the impact of supplemental probiotics on fasting plasma glucose (FPG), glycated hemoglobin (HbA1c), fasting insulin, homeostasis model assessment of insulin resistance (HOMA-IR), lipid profile, and CRP level...
June 22, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28630037/a-mobile-app-for-the-self-management-of-type-1-diabetes-among-adolescents-a-randomized-controlled-trial
#16
Shivani Goyal, Caitlin A Nunn, Michael Rotondi, Amy B Couperthwaite, Sally Reiser, Angelo Simone, Debra K Katzman, Joseph A Cafazzo, Mark R Palmert
BACKGROUND: While optimal blood glucose control is known to reduce the long-term complications associated with type 1 diabetes mellitus, adolescents often struggle to achieve their blood glucose targets. However, their strong propensity toward technology presents a unique opportunity for the delivery of novel self-management interventions. To support type 1 diabetes self-management in this population, we developed the diabetes self-management app bant, which included wireless blood glucose reading transfer, out-of-range blood glucose trend alerts, coaching around out-of-range trend causes and fixes, and a point-based incentive system...
June 19, 2017: JMIR MHealth and UHealth
https://www.readbyqxmd.com/read/28619307/pilot-randomized-controlled-trial-of-a-mindfulness-based-group-intervention-in-adolescent-girls-at-risk-for-type-2-diabetes-with-depressive-symptoms
#17
RANDOMIZED CONTROLLED TRIAL
Lauren B Shomaker, Stephanie Bruggink, Bernadette Pivarunas, Amanda Skoranski, Jillian Foss, Ella Chaffin, Stephanie Dalager, Shelly Annameier, Jordan Quaglia, Kirk Warren Brown, Patricia Broderick, Christopher Bell
OBJECTIVE: (1) Evaluate feasibility and acceptability of a mindfulness-based group in adolescent girls at-risk for type 2 diabetes (T2D) with depressive symptoms, and (2) compare efficacy of a mindfulness-based versus cognitive-behavioral group for decreasing depressive symptoms and improving insulin resistance. DESIGN AND SETTING: Parallel-group, randomized controlled pilot trial conducted at a university. PARTICIPANTS: Thirty-three girls 12-17y with overweight/obesity, family history of diabetes, and elevated depressive symptoms were randomized to a six-week mindfulness-based (n=17) or cognitive-behavioral program (n=16)...
June 2017: Complementary Therapies in Medicine
https://www.readbyqxmd.com/read/28616805/effects-of-insulin-plus-glucagon-like-peptide-1-receptor-agonists-glp-1ras-in-treating-type-1-diabetes-mellitus-a-systematic-review-and-meta-analysis
#18
REVIEW
Weihao Wang, Hongyan Liu, Shumin Xiao, Shuaihui Liu, Xin Li, Pei Yu
INTRODUCTION: Combination therapy with insulin and glucagon-like peptide-1 receptor agonists (GLP-1RAs) has already been proven an efficient treatment option for type 2 diabetes. This combination can effectively improve glycated hemoglobin levels, cause weight loss and reduce the dosage of insulin. In addition, it can also reduce the risk of hypoglycemia. Several randomized controlled trials have confirmed that this treatment may be just as effective for type 1 diabetes mellitus (T1DM) patients...
June 14, 2017: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://www.readbyqxmd.com/read/28616804/hypoglycemic-event-frequency-and-the-effect-of-continuous-glucose-monitoring-in-adults-with-type-1-diabetes-using-multiple-daily-insulin-injections
#19
Tonya Riddlesworth, David Price, Nathan Cohen, Roy W Beck
INTRODUCTION: The benefits of continuous glucose monitoring (CGM) in type 1 diabetes have been established among adults using insulin pumps. The DIAMOND randomized clinical trial examined the effectiveness of using CGM in improving glycemic control in participants using insulin injections. The frequency of hypoglycemic events in this trial has not been previously examined. METHODS: Adults with type 1 diabetes using multiple daily insulin injections (MDI) with A1C values of 7...
June 14, 2017: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://www.readbyqxmd.com/read/28611856/a-randomized-controlled-trial-of-vildagliptin-versus-alogliptin-effective-switch-from-sitagliptin-in-patients-with-type-2-diabetes
#20
Erina Shigematsu, Tadashi Yamakawa, Mari S Oba, Jun Suzuki, Jo Nagakura, Kazuaki Kadonosono, Yasuo Terauchi
BACKGROUND: We investigated the effects of vildagliptin or alogliptin on blood glucose and hemoglobin A1c (HbA1c) in patients with type 2 diabetes inadequately controlled by sitagliptin. METHODS: In a single-center open-label trial, 35 patients with inadequate glycemic control on sitagliptin therapy (50 mg once daily) were randomly switched to treatment with vildagliptin (50 mg twice daily) or alogliptin (25 mg once daily). After 12 weeks, patients who failed to achieve the target HbA1c level of < 7...
July 2017: Journal of Clinical Medicine Research
keyword
keyword
115696
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"