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https://www.readbyqxmd.com/read/28627939/off-label-prescribing-for-children-with-chronic-diseases-in-nigeria-findings-and-implications
#1
Kazeem Adeola Oshikoya, Ibrahim Adekunle Oreagba, Brian Godman, Joseph Fadare, Samuel Orubu, Amos Massele, Idowu Odunayo Senbanjo
BACKGROUND AND AIMS: Prescribing medicines in an off-label manner for children with chronic conditions is sparsely documented, even more so among developing countries. This needs addressing. The objective was to investigate the extent of this prescribing among children with epilepsy, asthma, and sickle cell anaemia in Nigeria. METHODS: Prescriptions for children ≤16 years documented in their case files that attended paediatric clinics in Lagos, Nigeria, for these three conditions between January and October 2015, were reviewed retrospectively to extract data on the medicines prescribed...
June 19, 2017: Expert Opinion on Drug Safety
https://www.readbyqxmd.com/read/28604245/state-of-the-art-or-the-art-of-medicine-transnational-mobility-and-perceptions-of-multiple-biomedicines-among-nigerian-physicians-in-the-u-s
#2
Judith Schühle
Over the last 40 years, several thousand Nigerian-trained doctors have migrated to the U.S. to practice in what they regard as the state-of-the-art of global biomedicine. Based on interviews with Nigerian physicians, this article shows how their professional mobility, and their transition to the new professional environment of U.S. biomedicine, makes them aware of local differences in practicing medicine. Adapting to local ways of practicing in the U.S. creates a new sense of belonging and professional identity...
June 12, 2017: Global Public Health
https://www.readbyqxmd.com/read/28592256/high-prevalence-of-complementary-and-alternative-medicine-use-among-patients-with-sickle-cell-disease-in-a-tertiary-hospital-in-lagos-south-west-nigeria
#3
A A Busari, M A Mufutau
BACKGROUND: Attention and interest in the use of complementary and alternative medicine (CAM) has been reignited globally, most especially in patients with chronic diseases. Sickle cell disease (SCD) is one of such chronic diseases associated with devastating clinical and psychosocial consequences, thus leading those affected to seek alternative treatment apart from orthodox medicine. Hence, this study aimed to determine the prevalence, pattern and tolerability of the use of CAM in patients with SCD in the Lagos University Teaching Hospital (LUTH)...
June 7, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28588941/physicochemical-equivalence-of-generic-antihypertensive-medicines-equimeds-protocol-for-a-quality-of-medicines-assessment
#4
Julie Redfern, Rufus Adesoji Adedoyin, Sandra Ofori, Raghupathy Anchala, Vamadevan S Ajay, Luciano De Andrade, Jose Zelaya, Harparkash Kaur, Dina Balabanova, Mahmoud U Sani
BACKGROUND: Prevention and optimal management of hypertension in the general population is paramount to the achievement of the World Heart Federation (WHF) goal of reducing premature cardiovascular disease (CVD) mortality by 25% by the year 2025 and widespread access to good quality antihypertensive medicines is a critical component for achieving the goal. Despite research and evidence relating to other medicines such as antimalarials and antibiotics, there is very little known about the quality of generic antihypertensive medicines in low-income and middle-income countries...
August 2016: BMJ Global Health
https://www.readbyqxmd.com/read/28539125/do-anti-malarials-in-africa-meet-quality-standards-the-market-penetration-of-non-quality-assured-artemisinin-combination-therapy-in-eight-african-countries
#5
Paul N Newton, Kara Hanson, Catherine Goodman
BACKGROUND: Quality of artemisinin-based combination therapy (ACT) is important for ensuring malaria parasite clearance and protecting the efficacy of artemisinin-based therapies. The extent to which non quality-assured ACT (non-QAACT), or those not granted global regulatory approval, are available and used to treat malaria in endemic countries is poorly documented. This paper uses national and sub-national medicine outlet surveys conducted in eight study countries (Benin, Kinshasa and Kantanga [Democratic Republic of the Congo, DRC], Kenya, Madagascar, Nigeria, Tanzania, Uganda and Zambia) between 2009 and 2015 to describe the non-QAACT market and to document trends in availability and distribution of non-QAACT in the public and private sector...
May 25, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28526075/testing-times-trends-in-availability-price-and-market-share-of-malaria-diagnostics-in-the-public-and-private-healthcare-sector-across-eight-sub-saharan-african-countries-from-2009-to-2015
#6
Kara Hanson, Catherine Goodman
BACKGROUND: The World Health Organization guidelines have recommended that all cases of suspected malaria should receive a confirmatory test with microscopy or a malaria rapid diagnostic test (RDT), however evidence from sub-Saharan Africa (SSA) illustrates that only one-third of children under five with a recent fever received a test. The aim of this study was to evaluate availability, price and market share of microscopy and RDT from 2009/11 to 2014/15 in 8 SSA countries, to better understand barriers to improving access to malaria confirmatory testing in the public and private health sectors...
May 19, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28512606/antimicrobial-activity-of-nigerian-medicinal-plants
#7
REVIEW
Madubuike Umunna Anyanwu, Rosemary Chinazam Okoye
Antimicrobial resistance (AMR) is currently one of the major threats facing mankind. The emergence and rapid spread of multi- and pan-drug-resistant organisms (such as vancomycin-, methicillin-, extended-spectrum β-lactam-, carbapenem- and colistin-resistant organisms) has put the world in a dilemma. The health and economic burden associated with AMR on a global scale are dreadful. Available antimicrobials have been misused and are almost ineffective with some of these drugs associated with dangerous side effects in some individuals...
April 2017: Journal of Intercultural Ethnopharmacology
https://www.readbyqxmd.com/read/28503221/management-of-musculoskeletal-pain-in-retail-drug-outlets-within-a-nigerian-community-a-descriptive-study
#8
Samirah N Abdu-Aguye, Aishatu Shehu, Ubaidullah I Ahmad
OBJECTIVE: This work aimed to describe attitudes and practices of both community pharmacies and patent and proprietary medicine vendor (PPMV) outlets towards over-the-counter (OTC) analgesic use for musculoskeletal pain states within Zaria, Nigeria. METHODS: The study was carried out in 2 phases from May to August 2016. Phase one was a cross-sectional survey of 40 retail drug outlets (10 community pharmacies and 30 PPMVs). A simulated patient scenario of a young adult male complaining of acute onset back pain was used to collect data on the type and quality of analgesic recommended, duration of consultation, as well as nature of information provided during the drug dispensing process...
January 2017: Pharmacy Practice
https://www.readbyqxmd.com/read/28497878/pharmacist-prescribing-a-cross-sectional-survey-of-the-views-of-pharmacists-in-nigeria
#9
Asa Auta, Barry Strickland-Hodge, Julia Maz, Shalkur David
OBJECTIVES: This study was carried out to: (1) explore the views of pharmacists in Nigeria on the extension of prescribing authority to them and determine their willingness to be prescribers and (2) identify the potential facilitators and barriers to introducing pharmacist prescribing in Nigeria. METHOD: An online cross-sectional survey was conducted from August to October 2014 among 775 pharmacists recruited from the Facebook group of the Pharmaceutical Society of Nigeria using a simple random technique...
May 12, 2017: International Journal of Pharmacy Practice
https://www.readbyqxmd.com/read/28492210/predictors-of-quality-of-life-in-patients-with-diabetes-mellitus-in-two-tertiary-health-institutions-in-ghana-and-nigeria
#10
Grace K Ababio, Samuel Bosomprah, Adesola Olumide, Nicholas Aperkor, Chris Aimakhu, Audrey Oteng-Yeboah, Joan Agama, William F Chaplin, Kola S Okuyemi, Albert G B Amoah, Gbenga Ogedegbe
BACKGROUND: Patients with chronic diseases such as Type 2 diabetes mellitus (DM) usually have a relatively poor quality of life (QoL), because the cost of care (living expenses and health) or diet restrictions are heavily felt by these patients, and this is of a public health concern. However, limited data on DM QoL exist in Ghana and Nigeria. This makes it imperative for data to be collated in that regard. MATERIALS AND METHODS: We adopted the Strengthening The reporting of observational studies in epidemiology (STROBE) consensus checklist to survey the patients with DM seen at the diabetic clinic at the Department of Medicine of the Korle-Bu Teaching Hospital and University College Hospital, Ibadan, Nigeria...
January 2017: Nigerian Postgraduate Medical Journal
https://www.readbyqxmd.com/read/28480400/isolation-of-novel-para-pentyl-phenyl-benzoate-from-mondia-whitei-hook-f-skeels-periplocaceae-its-structure-synthesis-and-neuropharmacological-evaluation
#11
Taiwo Bamigboye J, Osasan Josephine Y, Olubiyi Olujide O, Oyemitan Idris A, Atoyebi Shakir A M, Elsegood Mark R J, Jones Raymond C F
BACKGROUND: Mondia whitei L. (Hook. F.) Skeels (Periplocaceae) is a medicinal plant used locally in managing pain, fever, loss of appetite and as aphrodiasc in the South-Western states of Nigeria. However, the fruit is consumed habitually in the South-Eastern states of Nigeria, leading to speculation that it may possess some central nervous system effect but which has not been scientifically investigated, hence this study. METHODOLOGY: Fresh fruits of Mondia whitei were collected and identified by a taxonomist...
2017: African Journal of Traditional, Complementary, and Alternative Medicines: AJTCAM
https://www.readbyqxmd.com/read/28469118/risk-perception-of-hepatitis-b-infection-and-uptake-of-hepatitis-b-vaccine-among-students-of-tertiary-institution-in-jos
#12
M P Chingle, I A Osagie, H Adams, D Gwomson, N Emeribe, A I Zoakah
BACKGROUND: Hepatitis B virus (HBV) Infection is endemic in Nigeria. Healthcare students are more vulnerable because of direct contact with patients' body fluids and blood. Risk perception of HBV and HB vaccine uptake are also poor. The aim of this study was to assess the level of risk perception of hepatitis B infection, and uptake of the HBV vaccine, between medical and other students of the University of Jos. METHODS: A comparative cross sectional study was conducted among 1,200 students of the departments of Medicine, Nursing sciences and Public Administration, University of Jos (400 from each arm) using a pretested self-administered questionnaire...
April 2017: Annals of African Medicine
https://www.readbyqxmd.com/read/28441956/what-happened-to-anti-malarial-markets-after-the-affordable-medicines-facility-malaria-pilot-trends-in-act-availability-price-and-market-share-from-five-african-countries-under-continuation-of-the-private-sector-co-payment-mechanism
#13
Sarah Tougher, Kara Hanson, Catherine Goodman
BACKGROUND: The private sector supplies anti-malarial treatment for large proportions of patients in sub-Saharan Africa. Following the large-scale piloting of the Affordable Medicines Facility-malaria (AMFm) from 2010 to 2011, a private sector co-payment mechanism (CPM) provided continuation of private sector subsidies for quality-assured artemisinin combination therapies (QAACT). This article analyses for the first time the extent to which improvements in private sector QAACT supply and distribution observed during the AMFm were maintained or intensified during continuation of the CPM through 2015 in Kenya, Madagascar, Nigeria, Tanzania and Uganda using repeat cross-sectional outlet survey data...
April 25, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28436326/evaluation-and-characterization-of-nutritive-properties-of-the-jelly-ear-culinary-medicinal-mushroom-auricularia-auricula-judae-agaricomycetes-from-nigeria
#14
Reginald Chibueze Ohiri, Essien Eka Bassey
This study investigated the nutritive properties of the culinary-medicinal mushroom Auricularia auricula- judae. From the analysis, among the major minerals, potassium was found in the highest concentration, with a value of 172.03 ± 8.62 mg/kg, whereas manganese had the highest concentration among trace elements, with a value of 1.66 ± 0.11 mg/kg. Glutamic acid was the amino acid detected in the largest amounts in this study, with a value of 10.09 ± 1.86 mg/kg. Although glutamine and asparagine were not detected in this mushroom, cysteine and methionine had the lowest concentrations, with values of 0...
2017: International Journal of Medicinal Mushrooms
https://www.readbyqxmd.com/read/28372550/complementary-and-alternative-medicine-use-results-from-a-descriptive-study-of-pregnant-women-in-udi-local-government-area-of-enugu-state-nigeria
#15
Jane-Lovena Onyiapat, Chinyelu Okafor, Ijeoma Okoronkwo, Agnes Anarado, Ekene Chukwukelu, Ada Nwaneri, Pat Okpala
BACKGROUND: The use of CAM by pregnant women is very popular in developed countries. The trend is increasing globally and lack of evidence of safety particularly when used during pregnancy may lead to complications. Pregnancy is a vulnerable period especially during the first trimester. There is scarcity of empirical evidence on CAM use particularly among women in Udi LGA of Enugu State and South East Nigeria. Moreover, studies carried out in Nigeria have been limited to herbal medicine use, which is one aspect of CAM...
April 4, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28357128/impact-of-comorbidity-on-adverse-drug-reaction-profile-in-a-cohort-of-patients-treated-with-artemisinin-combination-therapies-for-uncomplicated-malaria-in-nigeria
#16
Peter U Bassi, Adeline I Osakwe, Comfort K Ogar, Cassandra Elagbaje, Biyaya B Nwankwo, Sulayman T Balogun, Godwin N Ntadom, Ambrose O Isah
Artemisinin-based combination antimalarial therapy (ACTs), is still highly effective in uncomplicated falciparum malaria, however, there remain some concerns in relation to its safety and tolerability. Comorbid disease conditions may influence susceptibility to adverse drug reactions (ADRs) as the presence of multiple disease conditions may predisposes patients to ADRs due to the use of many medicines. There is therefore need to assess the impact of comorbidities on the ADR profile of malaria patients treated with ACTs...
April 2017: Pharmacology Research & Perspectives
https://www.readbyqxmd.com/read/28336470/bioassay-guided-isolation-of-active-principles-from-nigerian-medicinal-plants-identifies-new-trypanocides-with-low-toxicity-and-no-cross-resistance-to-diamidines-and-arsenicals
#17
Godwin Unekwuojo Ebiloma, John Ogbaji Igoli, Evangelos Katsoulis, Anne-Marie Donachie, Anthonius Eze, Alexander Ian Gray, Harry P de Koning
ETHNOPHARMACOLOGICAL RELEVANCE: Leaves from the plant species studied herein are traditionally used in northern Nigeria against various protozoan infections. However, none of these herbal preparations have been standardized, nor have their toxicity to mammalian cells been investigated. In search of improved and non-toxic active antiprotozoal principles that are not cross-resistant with current anti-parasitics, we here report the results of the in vitro screening of extracts from seven selected medicinal plant species (Centrosema pubescens, Moringa oleifera, Tridax procumbens, Polyalthia longifolia, Newbouldia laevis, Eucalyptus maculate, Jathropha tanjorensis), used traditionally to treat kinetoplastid infections in Nigeria, and the isolation of their bioactive principles...
March 20, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28327163/injuries-in-male-and-female-semi-professional-football-soccer-players-in-nigeria-prospective-study-of-a-national-tournament
#18
Oluwatoyosi Babatunde Alex Owoeye, Ayoola Ibifubara Aiyegbusi, Oluwaseun Akinleye Fapojuwo, Oluwaseun Abdulganiyu Badru, Anike Rasheedat Babalola
BACKGROUND: Research on the epidemiology of football injuries in Africa is very sparse despite its importance for injury prevention planning in a continent with limited sports medicine resources. The vast majority of studies available in literature were conducted in Europe and only a very few studies have prospectively reported the pattern of football injury in Africa. The purpose of this study was to evaluate the incidence and pattern of injuries in a cohort of male and female semi-professional football players in Nigeria...
March 21, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28326840/a-new-benzophenone-glycoside-from-the-leaves-of-mitracarpus-villosus
#19
Kenneth G Ngwoke, Njideka Orame, Shuai Liu, Festus B C Okoye, Georgios Daletos, Peter Proksch
A new benzophenone glycoside, mitraphenone A (1), together with three known compounds (2-4) were isolated from the leaves of the traditionally used medicinal plant Mitracarpus villosus (Rubiaceae) collected in Nigeria. A combination of one- and two-dimensional NMR spectroscopic and mass spectrometric measurements were carried out to identify the structure of 1. All isolated compounds (1-4) were screened for their antibacterial activity against several Gram-positive and Gram-negative bacteria. Compound 1 exhibited moderate activity against Enterococcus faecium (strains ATCC 35667 and ATCC 700221) and Staphylococcus aureus ATCC 25923 with MIC values ranging from 25 to 50 μM...
March 22, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28256303/polyphenol-rich-fraction-of-parquetina-nigrescens-mitigates-dichlorvos-induced-neurotoxicity-and-apoptosis
#20
Grace Onyeche Ochigbo, Adebowale Bernard Saba, Ademola Adetokunbo Oyagbemi, Temidayo Olutayo Omobowale, Ebunoluwa Racheal Asenuga
BACKGROUND: Parquetina nigrescens (Afzel.) Bullock of the family Asclepiadaceae is known for its antioxidant effects with wide range of uses in Southwestern Nigeria especially in traditional medicine. This study was undertaken to explore if polyphenol-rich fraction (prf) from P. nigrescens will ameliorate dichlorvos-induced neurotoxicity and apoptosis. The exploration utilized evaluation of markers of oxidative stress, apoptosis and serum acetylcholinesterase (AchE) levels. METHODS: Forty Wistar rats randomly placed in four groups were utilized for the study...
January 2017: Journal of Ayurveda and Integrative Medicine
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