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JOURNAL ARTICLE
Hatice Ulu Aydin, Ilknur Cifci Tekinarslan, Yesim Gulec Aslan
The pattern of behaviors and abilities that reflect the core characteristics of students with autism spectrum disorder (ASD) and an environment that lacks the ability to understand individuals with ASD can make these students targets of bullying. Bullying is a serious problem for students with ASD, and practices against it are important in terms of improving students' coping strategies and overall well-being. In this study, we used a multiple probe model with an interprobe phase across participants to evaluate the effectiveness of the power card strategy to teach three students with ASD to respond to bullying...
November 14, 2023: Journal of Autism and Developmental Disorders
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JOURNAL ARTICLE
Ismail A Ahmed, Robert C Froemke
A new study has identified the periaqueductal gray as an important brain region for play and tickle behavior in rats.
November 6, 2023: Current Biology: CB
#23
JOURNAL ARTICLE
Seyed Abolfazl Tohidast, Faezeh Fazeli, Golnoosh Golmohammadi, Ronald C Scherer, Banafshe Mansuri
INTRODUCTION: Smoking is a dangerous behavior for the human body and the vocal tract. Smoking can cause several laryngeal and vocal tract symptoms in smokers. One of these symptoms can be physical discomfort experienced by this population. Therefore, the aim of the present study was to investigate vocal tract discomfort (VTD) in smokers compared to healthy non-smoker participants. MATERIALS AND METHODS: The smokers group was forty-eight men with a mean age of 47...
October 30, 2023: Journal of Voice
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JOURNAL ARTICLE
Sara Mosca, Qianqi Lin, Robert Stokes, Tehmina Bharucha, Bevin Gangadharan, Rebecca Clarke, Laura Gomez Fernandez, Michael Deats, John Walsby-Tickle, Benediktus Yohan Arman, Shrikrishna R Chunekar, Kundan D Patil, Sunil Gairola, Kerlijn Van Assche, Susanna Dunachie, Hamid A Merchant, Rutendo Kuwana, Alexandrine Maes, James McCullagh, Céline Caillet, Nicole Zitzmann, Paul N Newton, Pavel Matousek
Preventing, detecting, and responding to substandard and falsified vaccines is of critical importance for ensuring the safety, efficacy, and public trust in vaccines. This is of heightened importance in context of public health crisis, such as the COVID-19 pandemic, in which extreme world-wide shortages of vaccines provided a fertile ground for exploitation by falsifiers. Here, a proof-of-concept study explored the feasibility of using a handheld Spatially Offset Raman Spectroscopy (SORS) device to authenticate COVID-19 vaccines through rapid analysis of unopened vaccine vials...
October 13, 2023: Vaccine
#25
JOURNAL ARTICLE
Brittany Notice, Elizabeth Soffer, Kelly Tickle, Yijin Xiang, Beatrice E Gee, Robert F Sidonio, Nancy Sokkary, Glaivy Batsuli
BACKGROUND: Sickle cell disease (SCD) is associated with hypercoagulability, but adults with SCD also have an increased incidence of bleeding including heavy menstrual bleeding (HMB). HMB is common among adolescent females, but the impact of HMB in pediatric SCD is unclear. The objectives of this study were to examine menstrual health status, knowledge, and quality of life (QOL). METHODS: We performed a single-institutional multi-clinic cross-sectional study comprised of a five-part survey in pediatric participants with SCD...
October 16, 2023: Pediatric Blood & Cancer
#26
JOURNAL ARTICLE
Quanxiao Liu, Tereza Ilčíková, Mariia Radchenko, Markéta Junková, Marek Špinka
BACKGROUND: Play is a common and developmentally important behaviour in young mammals. Specifically in Norway rats (Rattus norvegicus), reduced opportunity to engage in rough-and-tumble (RT) play has been associated with impaired development in social competence. However, RT play is a complex behaviour having both a kinematic aspect (i.e., performing complex 3D manoeuvres during play fights) and a social aspect (interacting with a playful partner). There has been little research so far on disentangling the two aspects in RT play, especially on how these two aspects affect the affective appraisal of the intense physical contact during play...
October 12, 2023: Frontiers in Zoology
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JOURNAL ARTICLE
Amelia Staton, David Dawson, Hannah Merdian, Anna Tickle, Tammy Walker
OBJECTIVES: Individuals with a diagnosis of FND report experiencing stigma in medical settings, however, there is a paucity of research exploring their experiences in psychological services. The aim of this research was to explore experiences of accessing UK psychological services, from the perspective of those with FND. METHODS: This study utilised a qualitative approach with data collected from semi-structured interviews (n = 15) and analysed using reflexive thematic analysis...
October 6, 2023: Psychology and Psychotherapy
#28
JOURNAL ARTICLE
Ana Belén Maestre-Hernández, Silvia Pérez-Piñero, Francisco Javier López-Román, Luis Andreu-Caravaca, Antonio J Luque-Rubia, Domingo J Ramos-Campo, María José Díaz-Silvestre, Vicente Ávila-Gandía
INTRODUCTION: Beta-alanine is a non-essential amino acid that has been a focus of increasing research by its role as ergogenic aid to improve muscle performance. METHODS: A randomized, double-blind and controlled trial was conducted to determine the effect of a nutritional supplement of a sustained-release formulation of β-alanine in recreational trained men. The active product was an innovative sustained-release β-alanine microgranules powder blend, administered at high doses (15 g/day) divided into 3 intakes during 30 days...
2023: Frontiers in Nutrition
#29
JOURNAL ARTICLE
Factors influencing behavioral cough suppression therapy in children with nonspecific chronic cough.
Robert Brinton Fujiki, Miranda L Wright, Amanda E Fujiki, Susan L Thibeault
BACKGROUND: Behavioral cough suppression therapy (BCST) with a speech-language pathologist is a common treatment for chronic nonspecific cough (a.k.a., tic cough) in children. Yet, the outcomes and duration of pediatric BCST have eluded formal investigation. This study examined whether BCST improves cough in children with nonspecific cough and factors that predict the course of treatment. Additionally, the cough characteristics and comorbidities associated with the condition were examined...
December 2023: Pediatric Pulmonology
#30
Pablo Vajas, Erica Von Essen, Lara Tickle, Marlène Gamelon
No abstract text is available yet for this article.
September 9, 2023: Ambio
#31
JOURNAL ARTICLE
Aishwari Talhan, Yongjae Yoo, Jeremy R Cooperstock
The ability to deliver sensations of human-like touch within virtual reality remains an important challenge to immersive, realistic experiences. Since conventional haptic actuators impart distinctively unnatural effects, we instead tackle this challenge through the design of a rendering mechanism using soft pneumatic actuators (SPA), embedded within a wearable jacket. The resulting system is then evaluated for its ability to mimic realistic touch gesture sensations of grab, touch, tap, and tickle as performed by human fingertips...
August 15, 2023: IEEE Transactions on Haptics
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JOURNAL ARTICLE
Minzhe Guo, Michael P Morley, Cheng Jiang, Yixin Wu, Guangyuan Li, Yina Du, Shuyang Zhao, Andrew Wagner, Adnan Cihan Cakar, Michal Kouril, Kang Jin, Nathan Gaddis, Joseph A Kitzmiller, Kathleen Stewart, Maria C Basil, Susan M Lin, Yun Ying, Apoorva Babu, Kathryn A Wikenheiser-Brokamp, Kyu Shik Mun, Anjaparavanda P Naren, Geremy Clair, Joshua N Adkins, Gloria S Pryhuber, Ravi S Misra, Bruce J Aronow, Timothy L Tickle, Nathan Salomonis, Xin Sun, Edward E Morrisey, Jeffrey A Whitsett, Yan Xu
Accurate cell type identification is a key and rate-limiting step in single-cell data analysis. Single-cell references with comprehensive cell types, reproducible and functionally validated cell identities, and common nomenclatures are much needed by the research community for automated cell type annotation, data integration, and data sharing. Here, we develop a computational pipeline utilizing the LungMAP CellCards as a dictionary to consolidate single-cell transcriptomic datasets of 104 human lungs and 17 mouse lung samples to construct LungMAP single-cell reference (CellRef) for both normal human and mouse lungs...
July 29, 2023: Nature Communications
#33
JOURNAL ARTICLE
Natalie Gloveli, Jean Simonnet, Wei Tang, Miguel Concha-Miranda, Eduard Maier, Anton Dvorzhak, Dietmar Schmitz, Michael Brecht
The persistence of play after decortication points to a subcortical mechanism of play control. We found that global blockade of the rat periaqueductal gray with either muscimol or lidocaine interfered with ticklishness and play. We recorded vocalizations and neural activity from the periaqueductal gray of young, playful rats during interspecific touch, play, and tickling. Rats vocalized weakly to touch and more strongly to play and tickling. Periaqueductal gray units showed diverse but strong modulation to tickling and play...
July 14, 2023: Neuron
#34
JOURNAL ARTICLE
Kovilen Sawmynaden, Nicholas Wong, Sarah Davies, Richard Cowan, Richard Brown, David Tang, Maud Henry, David Tickle, David Matthews, Mark Carr, Preeti Bakrania, Hong Hoi Ting, Gareth Hall
Human epidermal growth factor receptor-2 (HER2) is a well-recognised biomarker associated with 25% of breast cancers. In most cases, early detection and/or treatment correlates with an increased chance of survival. This study, has identified and characterised a highly specific anti-HER2 single-domain antibody (sdAb), NM-02, as a potential theranostic tool. Complete structural description by X-ray crystallography has revealed a non-overlapping epitope with current anti-HER2 antibodies. To reduce the immunogenicity risk, NM-02 underwent a humanisation process and retained wild type-like binding properties...
2023: PloS One
#35
JOURNAL ARTICLE
Michael Hawrylycz, Maryann E Martone, Giorgio A Ascoli, Jan G Bjaalie, Hong-Wei Dong, Satrajit S Ghosh, Jesse Gillis, Ronna Hertzano, David R Haynor, Patrick R Hof, Yongsoo Kim, Ed Lein, Yufeng Liu, Jeremy A Miller, Partha P Mitra, Eran Mukamel, Lydia Ng, David Osumi-Sutherland, Hanchuan Peng, Patrick L Ray, Raymond Sanchez, Aviv Regev, Alex Ropelewski, Richard H Scheuermann, Shawn Zheng Kai Tan, Carol L Thompson, Timothy Tickle, Hagen Tilgner, Merina Varghese, Brock Wester, Owen White, Hongkui Zeng, Brian Aevermann, David Allemang, Seth Ament, Thomas L Athey, Cody Baker, Katherine S Baker, Pamela M Baker, Anita Bandrowski, Samik Banerjee, Prajal Bishwakarma, Ambrose Carr, Min Chen, Roni Choudhury, Jonah Cool, Heather Creasy, Florence D'Orazi, Kylee Degatano, Benjamin Dichter, Song-Lin Ding, Tim Dolbeare, Joseph R Ecker, Rongxin Fang, Jean-Christophe Fillion-Robin, Timothy P Fliss, James Gee, Tom Gillespie, Nathan Gouwens, Guo-Qiang Zhang, Yaroslav O Halchenko, Nomi L Harris, Brian R Herb, Houri Hintiryan, Gregory Hood, Sam Horvath, Bingxing Huo, Dorota Jarecka, Shengdian Jiang, Farzaneh Khajouei, Elizabeth A Kiernan, Huseyin Kir, Lauren Kruse, Changkyu Lee, Boudewijn Lelieveldt, Yang Li, Hanqing Liu, Lijuan Liu, Anup Markuhar, James Mathews, Kaylee L Mathews, Chris Mezias, Michael I Miller, Tyler Mollenkopf, Shoaib Mufti, Christopher J Mungall, Joshua Orvis, Maja A Puchades, Lei Qu, Joseph P Receveur, Bing Ren, Nathan Sjoquist, Brian Staats, Daniel Tward, Cindy T J van Velthoven, Quanxin Wang, Fangming Xie, Hua Xu, Zizhen Yao, Zhixi Yun, Yun Renee Zhang, W Jim Zheng, Brian Zingg
Characterizing cellular diversity at different levels of biological organization and across data modalities is a prerequisite to understanding the function of cell types in the brain. Classification of neurons is also essential to manipulate cell types in controlled ways and to understand their variation and vulnerability in brain disorders. The BRAIN Initiative Cell Census Network (BICCN) is an integrated network of data-generating centers, data archives, and data standards developers, with the goal of systematic multimodal brain cell type profiling and characterization...
June 2023: PLoS Biology
#36
JOURNAL ARTICLE
Dean Tickles, Daniel Friedman
No abstract text is available yet for this article.
June 9, 2023: Physics of Life Reviews
#37
JOURNAL ARTICLE
Brian J Haas, Alexander Dobin, Mahmoud Ghandi, Anne Van Arsdale, Timothy Tickle, James T Robinson, Riaz Gillani, Simon Kasif, Aviv Regev
Here, we present FusionInspector for in silico characterization and interpretation of candidate fusion transcripts from RNA sequencing (RNA-seq) and exploration of their sequence and expression characteristics. We applied FusionInspector to thousands of tumor and normal transcriptomes and identified statistical and experimental features enriched among biologically impactful fusions. Through clustering and machine learning, we identified large collections of fusions potentially relevant to tumor and normal biological processes...
May 22, 2023: Cell Rep Methods
#38
JOURNAL ARTICLE
Caixia Li, Xiling Lu, Fei Gao, Eunice Lee, Carmen W H Chan
OBJECTIVE: Hepatocellular carcinoma (HCC) is frequently diagnosed late. Although ultrasound-based HCC screening is recommended, its effectiveness is restricted by underutilization. This study aimed to develop a nurse-led decision counseling program used to improve HCC screening in patients with hepatitis B and to evaluate its feasibility in terms of process, resources, management, and cultural acceptance. METHODS: The nurse-led decision counseling program was developed following the Medical Research Council framework and the preventive health model...
June 2023: Asia-Pacific Journal of Oncology Nursing
#39
JOURNAL ARTICLE
Nikki Tickle, Debra K Creedy, Amanda G Carter, Janice Bass, Jenny Gamble
PROBLEM: Little is known about the educational impact of providing routine, online feedback from women on midwifery student learning and clinical practice. BACKGROUND: Feedback on students' clinical performance has historically been provided by lecturers and clinical supervisors. Women's feedback is not routinely collected or evaluated for impact on student learning. AIM: To evaluate the impact of women's feedback about continuity of care experiences with a midwifery student on learning and practice...
May 26, 2023: Women and Birth
#40
JOURNAL ARTICLE
Tingting Xu, Ye Yang, Wenzhi Zhan, Mingtong Lin, Wenbin Ding, Zhiyin Chen, Yuling Li, Dongting Xu, Kefang Lai
BACKGROUND: Not all gastroesophageal reflux-induced cough (GERC) patients respond to anti-reflux treatment. It is not certain whether reflux-related symptoms or other clinical characteristics could indicate a successful response to anti-reflux treatment. In this study, we aimed to investigate the relationship between clinical features and anti-reflux response. METHODS: We retrospectively analyzed the clinical characteristics of suspected GERC who had reflux-related symptoms or reflux evidence based on abnormal 24-hour esophageal pH value monitoring, or who had no evidence of other common causes of chronic cough in our chronic cough database with a standard case report form...
April 28, 2023: Journal of Thoracic Disease
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