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https://www.readbyqxmd.com/read/28811307/an-interview-with-jenny-nichols
#1
Aidan Maartens
Jennifer Nichols is a Principal Investigator at the Cambridge Stem Cell Institute and Department of Physiology, Development and Neuroscience at the University of Cambridge, UK. Her lab works on lineage segregation and the establishment of pluripotency in the mammalian embryo. In 2017 she was awarded the British Society for Developmental Biology's Cheryll Tickle Medal, given to mid-career female scientists with outstanding achievements in developmental biology. We met Jenny in her Cambridge office to talk about pluripotency in vitro and in vivo, the importance of collaboration in her career path, and what playing a musical instrument has in common with research...
August 15, 2017: Development
https://www.readbyqxmd.com/read/28761514/microsurgical-management-of-benign-lesions-interior-to-the-cavernous-sinus-a-case-series
#2
Forhad Hossain Chowdhury, Mohammod Raziul Haque
BACKGROUND: Benign lesion interior to the cavernous sinus (CS) is very rare. OBJECTIVE: In this series we found nonneoplastic lymphatic aggregation and osteoclastoma inside the CS which is very rare and probably not reported in literature. One interesting postoperative complaint of feeling of tickling down of warm water under the skin forehead was found in the patient of inflammatory disease of CS which is not reported in literature. Here we also describe our experiences of microsurgical management of series of benign lesions inside the CS...
July 2017: Asian Journal of Neurosurgery
https://www.readbyqxmd.com/read/28748624/the-relationship-between-coping-style-and-psychological-distress-in-people-with-head-and-neck-cancer-a-systematic-review
#3
REVIEW
Nicolle Morris, Nima Moghaddam, Anna Tickle, Sanchia Biswas
OBJECTIVE: Individuals diagnosed with head and neck cancer (HNC) are at an elevated risk of experiencing psychological distress and a reduced quality of life. The aim of this review was to systematically examine and assess the quality of empirical evidence on the associations between coping mechanisms and psychological distress among people with HNC. METHODS: CINAHL, MEDLINE, PsycINFO, EMBASE and Web of Science were accessed to conduct this review. Studies were included if they used reliable and valid measures to investigate the relationship between coping style and psychological distress...
July 27, 2017: Psycho-oncology
https://www.readbyqxmd.com/read/28671715/the-critically-endangered-western-chimpanzee-declines-by-80
#4
Hjalmar S Kühl, Tenekwetche Sop, Elizabeth A Williamson, Roger Mundry, David Brugière, Genevieve Campbell, Heather Cohen, Emmanuel Danquah, Laura Ginn, Ilka Herbinger, Sorrel Jones, Jessica Junker, Rebecca Kormos, Celestin Y Kouakou, Paul K N'Goran, Emma Normand, Kathryn Shutt-Phillips, Alexander Tickle, Elleni Vendras, Adam Welsh, Erin G Wessling, Christophe Boesch
African large mammals are under extreme pressure from unsustainable hunting and habitat loss. Certain traits make large mammals particularly vulnerable. These include late age at first reproduction, long inter-birth intervals, and low population density. Great apes are a prime example of such vulnerability, exhibiting all of these traits. Here we assess the rate of population change for the western chimpanzee, Pan troglodytes verus, over a 24-year period. As a proxy for change in abundance, we used transect nest count data from 20 different sites archived in the IUCN SSC A...
July 3, 2017: American Journal of Primatology
https://www.readbyqxmd.com/read/28652793/evaluation-of-a-novel-very-high-sun-protection-factor-moisturizer-in-adults-with-rosacea-prone-sensitive-skin
#5
Mathieu Grivet-Seyve, Francine Santoro, Nadège Lachmann
BACKGROUND/OBJECTIVE: Rosacea-prone sensitive skin requires high sun-protection factor (SPF) moisturizers. This study evaluated Daylong Extreme SPF 50+ lotion, a novel cream containing five ultraviolet filters, two emollients, and three skin conditioners. SUBJECTS AND METHODS: This was an open-label, single-center study. On day 1, before treatment, subjects answered a questionnaire on their skin conditions and sunscreen habits, and both subjects and dermatologist evaluated skin status...
2017: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/28628536/forging-alliances-in-interdisciplinary-rehabilitation-research-fairr-a-logic-model
#6
Simone V Gill, Mary A Khetani, Leanne Yinusa-Nyahkoon, Beth McManus, Paula M Gardiner, Linda Tickle-Degnen
In a patient-centered care era, rehabilitation can benefit from researcher-clinician collaboration to effectively and efficiently produce the interdisciplinary science that is needed to improve patient-centered outcomes. The authors propose the use of the Forging Alliances in Interdisciplinary Rehabilitation Research (FAIRR) logic model to provide guidance to rehabilitation scientists and clinicians who are committed to growing their involvement in interdisciplinary rehabilitation research. We describe the importance and key characteristics of the FAIRR model for conducting interdisciplinary rehabilitation research...
July 2017: American Journal of Physical Medicine & Rehabilitation
https://www.readbyqxmd.com/read/28625869/an-historical-perspective-on-the-pioneering-experiments-of-john-saunders
#7
REVIEW
Cheryll Tickle
John Saunders was a highly skilled embryologist who pioneered the study of limb development. His studies on chick embryos provided the fundamental framework for understanding how vertebrate limbs develop. This framework inspired generations of scientists and formed the bridge from experimental embryology to molecular mechanisms. Saunders investigated how feathers become organized into tracts in the skin of the chick wing and also identified regions of programmed cell death. He discovered that a region of thickened ectoderm that rims the chick wing bud - the apical ectodermal ridge - is required for outgrowth and the laying down of structures along the proximo-distal axis (long axis) of the wing, identified the zone of polarizing activity (ZPA; polarizing region) that controls development across the anteroposterior axis ("thumb to little finger "axis) and contributed to uncovering the importance of the ectoderm in development of structures along the dorso-ventral axis ( "back of hand to palm" axis)...
June 15, 2017: Developmental Biology
https://www.readbyqxmd.com/read/28573841/productive-efficiency-and-its-determinants-in-the-community-dental-service-in-the-north-west-of-england
#8
H Hill, S Birch, M Tickle, R McDonald, P Brocklehurst
OBJECTIVES: To assess the efficiency of service provision in the Community Dental Services and its determinants in the North-West of England. SETTING AND SAMPLE: 40 Community Dental Services sites operating across the North-West of England. BASIC RESEARCH DESIGN: A data envelopment analysis was undertaken of inputs (number of surgeries, hours worked by dental officers, therapists, hygienists and others) and outputs (treatments delivered, number of courses of treatment and patients seen) of the Community Dental Services to produce relative efficiency ratings by health authority...
June 2017: Community Dental Health
https://www.readbyqxmd.com/read/28571506/longitudinal-study-of-caries-development-from-childhood-to-adolescence
#9
E Hall-Scullin, H Whitehead, K Milsom, M Tickle, T-L Su, T Walsh
The World Health Organization (WHO) stated that globally, dental caries is the most important oral condition. To develop effective prevention strategies requires an understanding of how this condition develops and progresses over time, but there are few longitudinal studies of caries onset and progression in children. The aim of the study was to establish the pattern of caries development from childhood into adolescence and to explore the role of potential risk factors (age, sex, ethnicity, and social deprivation)...
July 2017: Journal of Dental Research
https://www.readbyqxmd.com/read/28565899/post-infectious-persistent-cough-pathogenesis-and-therapeutic-options
#10
Carlo Capristo, Giovanni A Rossi
Post-infectious cough is a common symptom associated with common colds and/or upper respiratory tract infection. This cough is expected to last for only for few days and resolve spontaneously, whilst when persists for longer than three weeks is defined "persistent" and is associated tickling or an irritating sensation in the throat which often leads to paroxysms of coughing. Persistent post-infectious cough can cause morbidity since it may interfere with usual living. Despite the recent advances in understanding the mechanisms that regulate cough, in physiological and pathological conditions, current therapeutic options for post-infectious cough are little or only moderately effective...
May 31, 2017: Minerva Pediatrica
https://www.readbyqxmd.com/read/28538821/sensory-symptoms-in-patients-undergoing-thyroidectomy
#11
COMPARATIVE STUDY
Lillian Fernandes de Araújo, Leonardo Wanderley Lopes, Priscila Oliveira Costa Silva, Victor Jose Ferreira Perrusi, Vívian Lisboa de Lucena Farias, Elma Heitmann Mares Azevedo
Purpose: To verify the occurrence of sensory symptoms in thyroidectomy patients pre- and post-operatively. Methods: This is a prospective, quantitative, descriptive study conducted with a sample of twelve patients undergoing thyroidectomy. The participants underwent visual laryngeal examination and responded to the Upper Aerodigestive Symptoms (UADS) and Vocal Tract Discomfort Scale (VTDS) questionnaires before and after the surgery. Results: There was higher occurrence of vocal fatigue, hoarseness, pharyngeal bolus, dry throat, and throat clearing preoperatively, whereas higher occurrence of hoarseness, vocal fatigue, cough, and pharyngeal bolus was observed postoperatively for the UADS...
May 15, 2017: CoDAS
https://www.readbyqxmd.com/read/28521109/cost-effectiveness-of-caries-prevention-in-practice-a-randomized-controlled-trial
#12
C O'Neill, H V Worthington, M Donaldson, S Birch, S Noble, S Killough, L Murphy, M Greer, J Brodison, R Verghis, M Tickle
A 2-arm parallel-group randomized controlled trial measured the cost-effectiveness of caries prevention in caries-free children aged 2 to 3 y attending general practice. The setting was 22 dental practices in Northern Ireland. Participants were centrally randomized into intervention (22,600 ppm fluoride varnish, toothbrush, a 50-mL tube of 1,450 ppm fluoride toothpaste, and standardized prevention advice) and control (advice only), both provided at 6-monthly intervals during a 3-y follow-up. The primary outcome measure was conversion from caries-free to caries-active states assessed by calibrated and blinded examiners; secondary outcome measures included decayed, missing, or filled teeth surfaces (dmfs); pain; and extraction...
May 1, 2017: Journal of Dental Research
https://www.readbyqxmd.com/read/28509865/detecting-and-classifying-human-touches-in-a-social-robot-through-acoustic-sensing-and-machine-learning
#13
Fernando Alonso-Martín, Juan José Gamboa-Montero, José Carlos Castillo, Álvaro Castro-González, Miguel Ángel Salichs
An important aspect in Human-Robot Interaction is responding to different kinds of touch stimuli. To date, several technologies have been explored to determine how a touch is perceived by a social robot, usually placing a large number of sensors throughout the robot's shell. In this work, we introduce a novel approach, where the audio acquired from contact microphones located in the robot's shell is processed using machine learning techniques to distinguish between different types of touches. The system is able to determine when the robot is touched (touch detection), and to ascertain the kind of touch performed among a set of possibilities: stroke, tap, slap, and tickle (touch classification)...
May 16, 2017: Sensors
https://www.readbyqxmd.com/read/28500871/the-ability-to-tickle-oneself-is-associated-with-level-of-psychometric-schizotypy-in-non-clinical-individuals
#14
Thomas J Whitford, Amelia M Mitchell, Damien J Mannion
A recent study (Lemaitre et al., 2016, Consciousness and Cognition, 41, 64-71) found that non-clinical individuals who scored highly on a psychometric scale of schizotypy were able to tickle themselves. The present study aimed to extend this finding by investigating whether the ability to tickle oneself was associated with level of psychometric schizotypy considered as a continuous variable. One hundred and eleven students completed the Schizotypal Personality Questionnaire (SPQ). A mechanical device delivered tactile stimulation to participants' palms...
May 10, 2017: Consciousness and Cognition
https://www.readbyqxmd.com/read/28450389/mertk-expressing-hepatic-macrophages-promote-the-resolution-of-inflammation-in-acute-liver-failure
#15
Evangelos Triantafyllou, Oltin T Pop, Lucia A Possamai, Annika Wilhelm, Evaggelia Liaskou, Arjuna Singanayagam, Christine Bernsmeier, Wafa Khamri, Gemma Petts, Rebecca Dargue, Scott P Davies, Joseph Tickle, Muhammed Yuksel, Vishal C Patel, Robin D Abeles, Zania Stamataki, Stuart M Curbishley, Yun Ma, Ian D Wilson, Muireann Coen, Kevin J Woollard, Alberto Quaglia, Julia Wendon, Mark R Thursz, David H Adams, Chris J Weston, Charalambos G Antoniades
OBJECTIVE: Acute liver failure (ALF) is characterised by overwhelming hepatocyte death and liver inflammation with massive infiltration of myeloid cells in necrotic areas. The mechanisms underlying resolution of acute hepatic inflammation are largely unknown. Here, we aimed to investigate the impact of Mer tyrosine kinase (MerTK) during ALF and also examine how the microenvironmental mediator, secretory leucocyte protease inhibitor (SLPI), governs this response. DESIGN: Flow cytometry, immunohistochemistry, confocal imaging and gene expression analyses determined the phenotype, functional/transcriptomic profile and tissue topography of MerTK+ monocytes/macrophages in ALF, healthy and disease controls...
April 27, 2017: Gut
https://www.readbyqxmd.com/read/28437140/a-proven-alternative-to-compression-bandaging
#16
Joy Tickle, Liz Ovens, Kirsten Mahoney, Sharon Hunt, Elaine Harris, Laura Hodgman
No abstract text is available yet for this article.
April 1, 2017: Journal of Wound Care
https://www.readbyqxmd.com/read/28428344/vascular-adhesion-protein-1-is-elevated-in-primary-sclerosing-cholangitis-is-predictive-of-clinical-outcome-and-facilitates-recruitment-of-gut-tropic-lymphocytes-to-liver-in-a-substrate-dependent-manner
#17
Palak J Trivedi, Joseph Tickle, Mette Nåmdal Vesterhus, Peter J Eddowes, Tony Bruns, Jani Vainio, Richard Parker, David Smith, Evaggelia Liaskou, Liv Wenche Thorbjørnsen, Gideon M Hirschfield, Kaisa Auvinen, Stefan G Hubscher, Marko Salmi, David H Adams, Chris J Weston
OBJECTIVE: Primary sclerosing cholangitis (PSC) is the classical hepatobiliary manifestation of IBD. This clinical association is linked pathologically to the recruitment of mucosal T cells to the liver, via vascular adhesion protein (VAP)-1-dependent enzyme activity. Our aim was to examine the expression, function and enzymatic activation of the ectoenzyme VAP-1 in patients with PSC. DESIGN: We examined VAP-1 expression in patients with PSC, correlated levels with clinical characteristics and determined the functional consequences of enzyme activation by specific enzyme substrates on hepatic endothelium...
April 20, 2017: Gut
https://www.readbyqxmd.com/read/28422581/-straight-from-the-heavens-into-your-bucket-domestic-rainwater-harvesting-as-a-measure-to-improve-water-security-in-a-subarctic-indigenous-community
#18
Nicholas Mercer, Maura Hanrahan
BACKGROUND: Black Tickle-Domino is an extremely water-insecure remote Inuit community in the Canadian subarctic that lacks piped-water. Drinking water consumption in the community is less than a third of the Canadian national average. Water insecurity in the community contributes to adverse health, economic, and social effects and requires urgent action. OBJECTIVES: To test the ability of domestic rainwater harvesting (DRWH) for the first time in the subarctic with the goal of improving water access and use in the community...
2017: International Journal of Circumpolar Health
https://www.readbyqxmd.com/read/28384364/rat-tickling-a-systematic-review-of-applications-outcomes-and-moderators
#19
Megan R LaFollette, Marguerite E O'Haire, Sylvie Cloutier, Whitney B Blankenberger, Brianna N Gaskill
INTRODUCTION: Rats initially fear humans which can increase stress and impact study results. Additionally, studying positive affective states in rats has proved challenging. Rat tickling is a promising habituation technique that can also be used to model and measure positive affect. However, current studies use a variety of methods to achieve differential results. Our objective was to systematically identify, summarize, and evaluate the research on tickling in rats to provide direction for future investigation...
2017: PloS One
https://www.readbyqxmd.com/read/28375708/a-randomized-controlled-trial-of-caries-prevention-in-dental-practice
#20
M Tickle, C O'Neill, M Donaldson, S Birch, S Noble, S Killough, L Murphy, M Greer, J Brodison, R Verghis, H V Worthington
We conducted a parallel group randomized controlled trial of children initially aged 2 to 3 y who were caries free, to prevent the children becoming caries active over the subsequent 36 mo. The setting was 22 dental practices in Northern Ireland, and children were randomly assigned by a clinical trials unit (CTU) (using computer-generated random numbers, with allocation concealed from the dental practice until each child was recruited) to the intervention (22,600-ppm fluoride varnish, toothbrush, 50-mL tube of 1,450 ppm fluoride toothpaste, and standardized, evidence-based prevention advice) or advice-only control at 6-monthly intervals...
July 2017: Journal of Dental Research
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