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https://www.readbyqxmd.com/read/28344564/investigating-the-grammatical-and-pragmatic-origins-of-wh-questions-in-children-with-autism-spectrum-disorders
#1
Manya Jyotishi, Deborah Fein, Letitia Naigles
Compared to typically developing children, children with autism (ASD) show delayed production of wh-questions. It is currently controversial the degree to which such deficits derive from social-pragmatic requirements and/or because these are complex grammatical structures. The current study employed the intermodal preferential looking (IPL) paradigm, which reduces social-pragmatic demands. The IPL paradigm can help distinguish these proposals, as successful comprehension promotes the "pragmatics-origins" argument whereas comprehension difficulties would implicate a "grammatical-origins" argument...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28293554/sonic-hedgehog-signaling-in-limb-development
#2
REVIEW
Cheryll Tickle, Matthew Towers
The gene encoding the secreted protein Sonic hedgehog (Shh) is expressed in the polarizing region (or zone of polarizing activity), a small group of mesenchyme cells at the posterior margin of the vertebrate limb bud. Detailed analyses have revealed that Shh has the properties of the long sought after polarizing region morphogen that specifies positional values across the antero-posterior axis (e.g., thumb to little finger axis) of the limb. Shh has also been shown to control the width of the limb bud by stimulating mesenchyme cell proliferation and by regulating the antero-posterior length of the apical ectodermal ridge, the signaling region required for limb bud outgrowth and the laying down of structures along the proximo-distal axis (e...
2017: Frontiers in Cell and Developmental Biology
https://www.readbyqxmd.com/read/28269402/myoelectric-intuitive-control-and-transcutaneous-electrical-stimulation-of-the-forearm-for-vibrotactile-sensation-feedback-applied-to-a-3d-printed-prosthetic-hand
#3
Enrique I Germany, Esteban J Pino, Pablo E Aqueveque
This paper presents the development of a myoelectric prosthetic hand based on a 3D printed model. A myoelectric control strategy based on artificial neural networks is implemented on a microcontroller for online position estimation. Position estimation performance achieves a correlation index of 0.78. Also a study involving transcutaneous electrical stimulation was performed to provide tactile feedback. A series of stimulations with controlled parameters were tested on five able-body subjects. A single channel stimulator was used, positioning the electrodes 8 cm on the wrist over the ulnar and median nerve...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28264677/does-capitation-affect-the-delivery-of-oral-healthcare-and-access-to-services-evidence-from-a-pilot-contact-in-northern-ireland
#4
Harry Hill, Stephen Birch, Martin Tickle, Ruth McDonald, Michael Donaldson, Donncha O'Carolan, Paul Brocklehurst
BACKGROUND: In May 2009, the Northern Ireland government introduced General Dental Services (GDS) contracts based on capitation in dental practices newly set up by a corporate dental provider to promote access to dental care in populations that had previously struggled to secure service provision. Dental service provision forms an important component of general health services for the population, but the implications of health system financing on care delivered and the financial cost of services has received relatively little attention in the research literature...
March 6, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28252338/changes-in-funding-developing-the-team
#5
Joy Tickle
No abstract text is available yet for this article.
March 2017: British Journal of Community Nursing
https://www.readbyqxmd.com/read/28247407/context-dependent-individual-differences-in-playfulness-in-male-rats
#6
Jessica F Lampe, Oliver Burman, Hanno Würbel, Luca Melotti
Play has been proposed as an indicator of positive emotions and welfare in higher vertebrates. This study investigated playfulness in male rats by exploring its consistency across motivational states (with/without prior short social isolation) and two age points at early and late adolescence. Twenty-four male Lister Hooded rats housed in cages of four underwent two play tests: conspecific Play-in-Pairs and Tickling by the experimenter, which were compared with play in the home cage and basal anxiety levels...
March 1, 2017: Developmental Psychobiology
https://www.readbyqxmd.com/read/28239951/the-technical-efficiency-of-oral-healthcare-provision-evaluating-role-substitution-in-national-health-service-dental-practices-in-england
#7
Harry Hill, Stephen Birch, Martin Tickle, Ruth McDonald, Paul Brocklehurst
OBJECTIVES: In many countries increasing use is being made of dental care professionals (DCPs) to provide aspects of clinical activity previously undertaken by dentists. This study evaluates the differences in practice efficiency associated with the utilisation of DCPs in the provision of General Dental Services in the National Health Service (NHS) in England. METHODS: One hundred twenty-one NHS practices completed a questionnaire and shared practice information held at the NHS Business Services Authority...
February 27, 2017: Community Dentistry and Oral Epidemiology
https://www.readbyqxmd.com/read/28227645/myoelectric-intuitive-control-and-transcutaneous-electrical-stimulation-of-the-forearm-for-vibrotactile-sensation-feedback-applied-to-a-3d-printed-prosthetic-hand
#8
Enrique I Germany, Esteban J Pino, Pablo E Aqueveque, Enrique I Germany, Esteban J Pino, Pablo E Aqueveque, Enrique I Germany, Pablo E Aqueveque, Esteban J Pino
This paper presents the development of a myoelectric prosthetic hand based on a 3D printed model. A myoelectric control strategy based on artificial neural networks is implemented on a microcontroller for online position estimation. Position estimation performance achieves a correlation index of 0.78. Also a study involving transcutaneous electrical stimulation was performed to provide tactile feedback. A series of stimulations with controlled parameters were tested on five able-body subjects. A single channel stimulator was used, positioning the electrodes 8 cm on the wrist over the ulnar and median nerve...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28202072/a-pilot-randomised-controlled-trial-evaluating-mini-and-conventional-implant-retained-dentures-on-the-function-and-quality-of-life-of-patients-with-an-edentulous-mandible
#9
Sarra Jawad, Craig Barclay, William Whittaker, Martin Tickle, Tanya Walsh
BACKGROUND: Total tooth loss (edentulism) can be a debilitating condition, impacting on ability to chew, speak and interact with others. The most common treatment is with complete removable dentures, which may be successful, but in the lower jaw, bone resorption that worsens over time makes denture-wearing difficult. Two dental implants in the mandible to retain the lower denture has been advocated as the gold standard of treatment, but has not been universally provided due largely to financial constraints and also patient fear...
February 15, 2017: BMC Oral Health
https://www.readbyqxmd.com/read/28099853/a-tissue-mapped-axolotl-de-novo-transcriptome-enables-identification-of-limb-regeneration-factors
#10
Donald M Bryant, Kimberly Johnson, Tia DiTommaso, Timothy Tickle, Matthew Brian Couger, Duygu Payzin-Dogru, Tae J Lee, Nicholas D Leigh, Tzu-Hsing Kuo, Francis G Davis, Joel Bateman, Sevara Bryant, Anna R Guzikowski, Stephanie L Tsai, Steven Coyne, William W Ye, Robert M Freeman, Leonid Peshkin, Clifford J Tabin, Aviv Regev, Brian J Haas, Jessica L Whited
Mammals have extremely limited regenerative capabilities; however, axolotls are profoundly regenerative and can replace entire limbs. The mechanisms underlying limb regeneration remain poorly understood, partly because the enormous and incompletely sequenced genomes of axolotls have hindered the study of genes facilitating regeneration. We assembled and annotated a de novo transcriptome using RNA-sequencing profiles for a broad spectrum of tissues that is estimated to have near-complete sequence information for 88% of axolotl genes...
January 17, 2017: Cell Reports
https://www.readbyqxmd.com/read/27994116/perspectives-on-the-history-of-evo-devo-and-the-contemporary-research-landscape-in-the-genomics-era
#11
Cheryll Tickle, Araxi O Urrutia
A fundamental question in biology is how the extraordinary range of living organisms arose. In this theme issue, we celebrate how evolutionary studies on the origins of morphological diversity have changed over the past 350 years since the first publication of the Philosophical Transactions of The Royal Society Current understanding of this topic is enriched by many disciplines, including anatomy, palaeontology, developmental biology, genetics and genomics. Development is central because it is the means by which genetic information of an organism is translated into morphology...
February 5, 2017: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
https://www.readbyqxmd.com/read/27986921/development-of-a-cancer-marker-activated-enzymatic-switch-from-the-herpes-simplex-virus-thymidine-kinase
#12
Nirav Y Shelat, Sidhartha Parhi, Marc Ostermeier
Discovery of new cancer biomarkers and advances in targeted gene delivery mechanisms have made gene-directed enzyme prodrug therapy (GDEPT) an attractive method for treating cancer. Recent focus has been placed on increasing target specificity of gene delivery systems and reducing toxicity in non-cancer cells in order to make GDEPT viable. To help address this challenge, we have developed an enzymatic switch that confers higher prodrug toxicity in the presence of a cancer marker. The enzymatic switch was derived from the herpes simplex virus thymidine kinase (HSV-TK) fused to the CH1 domain of the p300 protein...
December 15, 2016: Protein Engineering, Design & Selection: PEDS
https://www.readbyqxmd.com/read/27956212/voluntary-ethanol-consumption-changes-anticipatory-ultrasonic-vocalizations-but-not-novelty-response
#13
Erik J Garcia, Emily T Jorgensen, Lukas S Sprick, Mary E Cain
Novelty and sensation seeking (NSS) and affective disorders are correlated with earlier ethanol (ETOH) consumption, and sustained drinking into adulthood. Understanding the NSS response and affective response before and after voluntary ETOH consumption could elucidate important individual differences promoting sustained ETOH consumption. This study determined that NSS and affective response to rewarding stimulation-measured by ultrasonic vocalizations (USVs)-change after adolescent ETOH voluntary drinking. Rats were tested for their NSS response using the inescapable novelty test...
March 1, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/27902721/facial-indicators-of-positive-emotions-in-rats
#14
Kathryn Finlayson, Jessica Frances Lampe, Sara Hintze, Hanno Würbel, Luca Melotti
Until recently, research in animal welfare science has mainly focused on negative experiences like pain and suffering, often neglecting the importance of assessing and promoting positive experiences. In rodents, specific facial expressions have been found to occur in situations thought to induce negatively valenced emotional states (e.g., pain, aggression and fear), but none have yet been identified for positive states. Thus, this study aimed to investigate if facial expressions indicative of positive emotional state are exhibited in rats...
2016: PloS One
https://www.readbyqxmd.com/read/27900823/high-frequency-mechanostimulation-of-cell-adhesion
#15
Laith F Kadem, K Grace Suana, Michelle Holz, Wei Wang, Hannes Westerhaus, Rainer Herges, Christine Selhuber-Unkel
Cell adhesion is regulated by molecularly defined protein interactions and by mechanical forces, which can activate a dynamic restructuring of adhesion sites. Previous attempts to explore the response of cell adhesion to forces have been limited to applying mechanical stimuli that involve the cytoskeleton. In contrast, we here apply a new, oscillatory type of stimulus through push-pull azobenzenes. Push-pull azobenzenes perform a high-frequency, molecular oscillation upon irradiation with visible light that has frequently been applied in polymer surface relief grating...
January 2, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/27884965/-can-you-recommend-any-good-sti-apps-a-review-of-content-accuracy-and-comprehensiveness-of-current-mobile-medical-applications-for-stis-and-related-genital-infections
#16
Jo Gibbs, Voula Gkatzidou, Laura Tickle, Sarah R Manning, Tilna Tilakkumar, Kate Hone, Richard E Ashcroft, Pam Sonnenberg, S Tariq Sadiq, Claudia S Estcourt
OBJECTIVE: Seeking sexual health information online is common, and provision of mobile medical applications (apps) for STIs is increasing. Young people, inherently at higher risk of STIs, are avid users of technology, and apps could be appealing sources of information. We undertook a comprehensive review of content and accuracy of apps for people seeking information about STIs. METHODS: Search of Google Play and iTunes stores using general and specific search terms for apps regarding STIs and genital infections (except HIV), testing, diagnosis and management, 10 September 2014 to 16 September 2014...
November 24, 2016: Sexually Transmitted Infections
https://www.readbyqxmd.com/read/27853620/forward-modelling-the-rubber-hand-illusion-of-ownership-modifies-motor-sensory-predictions-by-the-brain
#17
Laura Aymerich-Franch, Damien Petit, Abderrahmane Kheddar, Gowrishankar Ganesh
The question of how we attribute observed body parts as our own, and the consequences of this attribution on our sensory-motor processes, is fundamental to understand how our brain distinguishes between self and other. Previous studies have identified interactions between the illusion of ownership, and multi-sensory integration and cross-sensory predictions by the brain. Here we show that illusory ownership additionally modifies the motor-sensory predictions by the brain. In our preliminary experiments, we observed a new numbness illusion following the classical rubber-hand illusion (RHI); brushing only the rubber hand after induction of the RHI results in illusory numbness in one's real hand...
August 2016: Royal Society Open Science
https://www.readbyqxmd.com/read/27853216/neuroscience-brain-circuit-for-tickling-found
#18
(no author information available yet)
No abstract text is available yet for this article.
November 17, 2016: Nature
https://www.readbyqxmd.com/read/27847355/crystal-structure-of-the-marburg-virus-vp35-oligomerization-domain
#19
Jessica F Bruhn, Robert N Kirchdoerfer, Sarah M Urata, Sheng Li, Ian J Tickle, Gérard Bricogne, Erica Ollmann Saphire
Marburg virus (MARV) is a highly pathogenic filovirus that is classified in a genus distinct from that of Ebola virus (EBOV) (genera Marburgvirus and Ebolavirus, respectively). Both viruses produce a multifunctional protein termed VP35, which acts as a polymerase cofactor, a viral protein chaperone, and an antagonist of the innate immune response. VP35 contains a central oligomerization domain with a predicted coiled-coil motif. This domain has been shown to be essential for RNA polymerase function. Here we present crystal structures of the MARV VP35 oligomerization domain...
January 15, 2017: Journal of Virology
https://www.readbyqxmd.com/read/27846607/neural-correlates-of-ticklishness-in-the-rat-somatosensory-cortex
#20
S Ishiyama, M Brecht
Rats emit ultrasonic vocalizations in response to tickling by humans. Tickling is rewarding through dopaminergic mechanisms, but the function and neural correlates of ticklishness are unknown. We confirmed that tickling of rats evoked vocalizations, approach, and unsolicited jumps (Freudensprünge). Recordings in the trunk region of the rat somatosensory cortex showed intense tickling-evoked activity in most neurons, whereas a minority of cells were suppressed by tickling. Tickling responses predicted nontactile neural responses to play behaviors, which suggests a neuronal link between tickling and play...
November 11, 2016: Science
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