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https://www.readbyqxmd.com/read/29201595/microbes-tickling-your-tummy-the-importance-of-the-gut-brain-axis-in-parkinson-s-disease
#1
REVIEW
Paula Perez-Pardo, Mitch Hartog, Johan Garssen, Aletta D Kraneveld
Purpose of Review: Patients suffering from Parkinson's disease (PD) are known to experience gastrointestinal dysfunction that might precede the onset of motor symptoms by several years. Evidence suggests an important role of the gut-brain axis in PD pathogenesis. These interactions might be essentially influenced by the gut microbiota. Here, we review recent findings supporting that changes in the gut microbiota composition might be a trigger for inflammation contributing to neurodegeneration in PD...
2017: Current Behavioral Neuroscience Reports
https://www.readbyqxmd.com/read/29191946/thrombopoietin-tickling-the-hsc-s-fancy
#2
Ah Ram Kim, Vijay G Sankaran
No abstract text is available yet for this article.
November 30, 2017: EMBO Molecular Medicine
https://www.readbyqxmd.com/read/29143821/erratum-the-neuropeptide-nmu-amplifies-ilc2-driven-allergic-lung-inflammation
#3
Antonia Wallrapp, Samantha J Riesenfeld, Patrick R Burkett, Raja-Elie E Abdulnour, Jackson Nyman, Danielle Dionne, Matan Hofree, Michael S Cuoco, Christopher Rodman, Daneyal Farouq, Brian J Haas, Timothy L Tickle, John J Trombetta, Pankaj Baral, Christoph S N Klose, Tanel Mahlakõiv, David Artis, Orit Rozenblatt-Rosen, Isaac M Chiu, Bruce D Levy, Monika S Kowalczyk, Aviv Regev, Vijay K Kuchroo
This corrects the article DOI: 10.1038/nature24029.
November 15, 2017: Nature
https://www.readbyqxmd.com/read/29120681/introducing-a-new-superabsorbent-dressing-to-manage-wound-exudate
#4
Joy Tickle
The production of wound exudate is a natural and normal consequence of healing. However, when the constituents, volume and consistency of the exudate alter, problems can occur. This article discusses the different types of exudate and its impact on both the patient and the clinician and outlines appropriate exudate assessment and effective management and dressing selection. If these are performed appropriately, this can improve quality of life for the patient and save time and money for healthcare providers...
November 8, 2017: British Journal of Nursing: BJN
https://www.readbyqxmd.com/read/29094780/the-effect-of-psychological-interventions-on-quality-of-life-in-patients-with-head-and-neck-cancer-a-systematic-review-and-meta-analysis
#5
L Calver, A Tickle, N Moghaddam, S Biswas
This systematic review and meta-analysis aimed to evaluate the effectiveness of psychological interventions in improving quality of life for head and neck cancer patients. Five databases were systematically searched in July 2016. Studies were included if they reported original empirical data from intervention studies utilising psychological approaches (excluding psychoeducational-only interventions) and provided data on quality of life outcomes. Six studies, involving 185 participants, fulfilled eligibility criteria...
November 2, 2017: European Journal of Cancer Care
https://www.readbyqxmd.com/read/29083027/a-longitudinal-study-of-the-relationship-between-dental-caries-and-obesity-in-late-childhood-and-adolescence
#6
Emma Patricia Hall-Scullin, Hilary Whitehead, Helen Rushton, Keith Milsom, Martin Tickle
OBJECTIVES: To determine whether caries experience in late childhood (aged 7-9 years) was predictive of adolescent obesity (ages 12-16 years) to inform the use of a common risk factor approach (CRFA) for prevention. METHODS: A cohort study was conducted in an area of North West England. Clinical assessment of caries took place using the same methodology at ages 7-9 years and 12-16 years. Body mass index (BMI) category was calculated from height and weight measurements using age and gender specific cut-offs at 12-16 years only...
October 30, 2017: Journal of Public Health Dentistry
https://www.readbyqxmd.com/read/29034599/process-and-impact-of-dialectical-behaviour-therapy-a-systematic-review-of-perceptions-of-clients-with-a-diagnosis-of-borderline-personality-disorder
#7
REVIEW
Hannah Little, Anna Tickle, Roshan das Nair
PURPOSE: To identify, appraise, and synthesize findings from qualitative studies of individuals diagnosed with borderline personality disorder who have experienced dialectical behaviour therapy, to gain further understanding of their perceptions of the process and impact of therapy. METHODS: We conducted a comprehensive systematic search of the literature from several online databases, and appraised them using an adapted version of the Critical Appraisal Skills Programme tool...
October 16, 2017: Psychology and Psychotherapy
https://www.readbyqxmd.com/read/28988193/using-the-esexual-health-clinic-to-access-chlamydia-treatment-and-care-via-the-internet-a-qualitative-interview-study
#8
Catherine R H Aicken, Lorna J Sutcliffe, Jo Gibbs, Laura J Tickle, Kate Hone, Emma M Harding-Esch, Catherine H Mercer, Pam Sonnenberg, S Tariq Sadiq, Claudia S Estcourt, Maryam Shahmanesh
OBJECTIVE: We developed the eSexual Health Clinic (eSHC), an innovative, complex clinical and public health intervention, embedded within a specialist sexual health service. Patients with genital chlamydia access their results online and are offered medical management via an automated online clinical consultation, leading to antibiotic collection from community pharmacy. A telephone helpline, staffed by Sexual Health Advisers, is available to support patients and direct them to conventional services if appropriate...
October 7, 2017: Sexually Transmitted Infections
https://www.readbyqxmd.com/read/28934614/development-of-mother-infant-interaction-in-tickling-play-the-relationship-between-infants-ticklishness-and-social-behaviors
#9
Konomi Ishijima, Koichi Negayama
This study examined the development of mother-infant tickling interaction and the relationship between infants' ticklishness and social behaviors including infants' looking at mothers' face, mothers' narrative tickling, and mothers' laughter. Twenty-two Japanese infants aged 5 months (n=10, five girls) and 7 months (n=12, four girls) and their mothers were videotaped. Results revealed that the mothers' narrative tickling was more frequent at 7 than at 5 months and the infants' strong ticklishness showed the same tendency...
September 18, 2017: Infant Behavior & Development
https://www.readbyqxmd.com/read/28927396/socioeconomic-disparities-in-orthodontic-treatment-outcomes-and-expenditure-on-orthodontics-in-england-s-state-funded-national-health-service-a-retrospective-observational-study
#10
Juliet Price, William Whittaker, Stephen Birch, Paul Brocklehurst, Martin Tickle
BACKGROUND: This study aimed to assess whether there are potential areas for efficiency improvements in the National Health Service (NHS) orthodontic service in North West England and to assess the socioeconomic status (SES)-related equity of the outcomes achieved by the NHS. METHODS: The study involved a retrospective analysis of 2008-2012 administrative data, and the study population comprised patients aged ≥10 who started NHS primary care orthodontic treatment in North West England in 2008...
September 19, 2017: BMC Oral Health
https://www.readbyqxmd.com/read/28902842/the-neuropeptide-nmu-amplifies-ilc2-driven-allergic-lung-inflammation
#11
Antonia Wallrapp, Samantha J Riesenfeld, Patrick R Burkett, Raja-Elie E Abdulnour, Jackson Nyman, Danielle Dionne, Matan Hofree, Michael S Cuoco, Christopher Rodman, Daneyal Farouq, Brian J Haas, Timothy L Tickle, John J Trombetta, Pankaj Baral, Christoph S N Klose, Tanel Mahlakõiv, David Artis, Orit Rozenblatt-Rosen, Isaac M Chiu, Bruce D Levy, Monika S Kowalczyk, Aviv Regev, Vijay K Kuchroo
Type 2 innate lymphoid cells (ILC2s) both contribute to mucosal homeostasis and initiate pathologic inflammation in allergic asthma. However, the signals that direct ILC2s to promote homeostasis versus inflammation are unclear. To identify such molecular cues, we profiled mouse lung-resident ILCs using single-cell RNA sequencing at steady state and after in vivo stimulation with the alarmin cytokines IL-25 and IL-33. ILC2s were transcriptionally heterogeneous after activation, with subpopulations distinguished by expression of proliferative, homeostatic and effector genes...
September 21, 2017: Nature
https://www.readbyqxmd.com/read/28882594/terbinafine-is-a-novel-and-selective-activator-of-the-two-pore-domain-potassium-channel-task3
#12
Paul D Wright, Emma L Veale, David McCoull, David C Tickle, Jonathan M Large, Emma Ococks, Gemma Gothard, Catherine Kettleborough, Alistair Mathie, Jeffrey Jerman
Two-pore domain potassium channels (K2Ps) are characterized by their four transmembrane domain and two-pore topology. They carry background (or leak) potassium current in a variety of cell types. Despite a number of important roles there is currently a lack of pharmacological tools with which to further probe K2P function. We have developed a cell-based thallium flux assay, using baculovirus delivered TASK3 (TWIK-related acid-sensitive K(+) channel 3, KCNK9, K2P9.1) with the aim of identifying novel, selective TASK3 activators...
November 4, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28873769/reconnecting-people-with-dementia-by-using-the-interactive-instrument-crdl
#13
Lisanne Teunissen, Tom Luyten, Luc de Witte
Dementia is a progressive brain disease with a decline in functioning over time. CRDL (pronounced as Cradle) is an interactive instrument, developed to stimulate communication between users through sound and touch. It recognises the intention of the touch (tickle, holding, grabbing, fondling, kneading, and tapping) and will adjust the sound accordingly. This qualitative observational study explores whether this innovative product has the potential to be used in elderly care to create a moment of interaction between the person with dementia and someone else or multiple others...
2017: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/28811307/an-interview-with-jenny-nichols
#14
Aidan Maartens
Jennifer Nichols is a Principal Investigator at the Cambridge Stem Cell Institute and Department of Physiology, Development and Neuroscience at the University of Cambridge, UK. Her lab works on lineage segregation and the establishment of pluripotency in the mammalian embryo. In 2017 she was awarded the British Society for Developmental Biology's Cheryll Tickle Medal, given to mid-career female scientists with outstanding achievements in developmental biology. We met Jenny in her Cambridge office to talk about pluripotency in vitro and in vivo, the importance of collaboration in her career path, and what playing a musical instrument has in common with research...
August 15, 2017: Development
https://www.readbyqxmd.com/read/28761514/microsurgical-management-of-benign-lesions-interior-to-the-cavernous-sinus-a-case-series
#15
Forhad Hossain Chowdhury, Mohammod Raziul Haque
BACKGROUND: Benign lesion interior to the cavernous sinus (CS) is very rare. OBJECTIVE: In this series we found nonneoplastic lymphatic aggregation and osteoclastoma inside the CS which is very rare and probably not reported in literature. One interesting postoperative complaint of feeling of tickling down of warm water under the skin forehead was found in the patient of inflammatory disease of CS which is not reported in literature. Here we also describe our experiences of microsurgical management of series of benign lesions inside the CS...
July 2017: Asian Journal of Neurosurgery
https://www.readbyqxmd.com/read/28748624/the-relationship-between-coping-style-and-psychological-distress-in-people-with-head-and-neck-cancer-a-systematic-review
#16
REVIEW
Nicolle Morris, Nima Moghaddam, Anna Tickle, Sanchia Biswas
OBJECTIVE: Individuals diagnosed with head and neck cancer (HNC) are at an elevated risk of experiencing psychological distress and a reduced quality of life. The aim of this review was to systematically examine and assess the quality of empirical evidence on the associations between coping mechanisms and psychological distress among people with HNC. METHODS: CINAHL, MEDLINE, PsycINFO, EMBASE and Web of Science were accessed to conduct this review. Studies were included if they used reliable and valid measures to investigate the relationship between coping style and psychological distress...
July 27, 2017: Psycho-oncology
https://www.readbyqxmd.com/read/28671715/the-critically-endangered-western-chimpanzee-declines-by-80
#17
Hjalmar S Kühl, Tenekwetche Sop, Elizabeth A Williamson, Roger Mundry, David Brugière, Genevieve Campbell, Heather Cohen, Emmanuel Danquah, Laura Ginn, Ilka Herbinger, Sorrel Jones, Jessica Junker, Rebecca Kormos, Celestin Y Kouakou, Paul K N'Goran, Emma Normand, Kathryn Shutt-Phillips, Alexander Tickle, Elleni Vendras, Adam Welsh, Erin G Wessling, Christophe Boesch
African large mammals are under extreme pressure from unsustainable hunting and habitat loss. Certain traits make large mammals particularly vulnerable. These include late age at first reproduction, long inter-birth intervals, and low population density. Great apes are a prime example of such vulnerability, exhibiting all of these traits. Here we assess the rate of population change for the western chimpanzee, Pan troglodytes verus, over a 24-year period. As a proxy for change in abundance, we used transect nest count data from 20 different sites archived in the IUCN SSC A...
September 2017: American Journal of Primatology
https://www.readbyqxmd.com/read/28652793/evaluation-of-a-novel-very-high-sun-protection-factor-moisturizer-in-adults-with-rosacea-prone-sensitive-skin
#18
Mathieu Grivet-Seyve, Francine Santoro, Nadège Lachmann
BACKGROUND/OBJECTIVE: Rosacea-prone sensitive skin requires high sun-protection factor (SPF) moisturizers. This study evaluated Daylong Extreme SPF 50+ lotion, a novel cream containing five ultraviolet filters, two emollients, and three skin conditioners. SUBJECTS AND METHODS: This was an open-label, single-center study. On day 1, before treatment, subjects answered a questionnaire on their skin conditions and sunscreen habits, and both subjects and dermatologist evaluated skin status...
2017: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/28628536/forging-alliances-in-interdisciplinary-rehabilitation-research-fairr-a-logic-model
#19
Simone V Gill, Mary A Khetani, Leanne Yinusa-Nyahkoon, Beth McManus, Paula M Gardiner, Linda Tickle-Degnen
In a patient-centered care era, rehabilitation can benefit from researcher-clinician collaboration to effectively and efficiently produce the interdisciplinary science that is needed to improve patient-centered outcomes. The authors propose the use of the Forging Alliances in Interdisciplinary Rehabilitation Research (FAIRR) logic model to provide guidance to rehabilitation scientists and clinicians who are committed to growing their involvement in interdisciplinary rehabilitation research. We describe the importance and key characteristics of the FAIRR model for conducting interdisciplinary rehabilitation research...
July 2017: American Journal of Physical Medicine & Rehabilitation
https://www.readbyqxmd.com/read/28625869/an-historical-perspective-on-the-pioneering-experiments-of-john-saunders
#20
REVIEW
Cheryll Tickle
John Saunders was a highly skilled embryologist who pioneered the study of limb development. His studies on chick embryos provided the fundamental framework for understanding how vertebrate limbs develop. This framework inspired generations of scientists and formed the bridge from experimental embryology to molecular mechanisms. Saunders investigated how feathers become organized into tracts in the skin of the chick wing and also identified regions of programmed cell death. He discovered that a region of thickened ectoderm that rims the chick wing bud - the apical ectodermal ridge - is required for outgrowth and the laying down of structures along the proximo-distal axis (long axis) of the wing, identified the zone of polarizing activity (ZPA; polarizing region) that controls development across the anteroposterior axis ("thumb to little finger "axis) and contributed to uncovering the importance of the ectoderm in development of structures along the dorso-ventral axis ( "back of hand to palm" axis)...
September 15, 2017: Developmental Biology
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