Read by QxMD icon Read


Tadeu A Fantaneanu, Benjamin Tolchin, Vincent Alvarez, Raymond Friolet, Kathleen Avery, Benjamin M Scirica, Molly O'Brien, Galen V Henderson, Jong Woo Lee
OBJECTIVE: Electroencephalogram (EEG) background reactivity is a reliable outcome predictor in cardiac arrest patients post therapeutic hypothermia. However, there is no consensus on modality testing and prior studies reveal only fair to moderate agreement rates. The aim of this study was to explore different stimulus modalities and report interrater agreements. METHODS: We studied a multicenter, prospectively collected cohort of cardiac arrest patients who underwent therapeutic hypothermia between September 2014 and December 2015...
September 10, 2016: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
Martin Tickle, Ciaran O'Neill, Michael Donaldson, Stephen Birch, Solveig Noble, Seamus Killough, Lynn Murphy, Margaret Greer, Julie Brodison, Rejina Verghis, Helen V Worthington
BACKGROUND: Dental caries is the most common disease of childhood. The NHS guidelines promote preventative care in dental practices, particularly for young children. However, the cost-effectiveness of this policy has not been established. OBJECTIVE: To measure the effects and costs of a composite fluoride intervention designed to prevent caries in young children attending dental services. DESIGN: The study was a two-arm, parallel-group, randomised controlled trial, with an allocation ratio of 1 : 1...
September 2016: Health Technology Assessment: HTA
Ella L James, Alex Lau-Zhu, Hannah Tickle, Antje Horsch, Emily A Holmes
BACKGROUND AND OBJECTIVES: Visuospatial working memory (WM) tasks performed concurrently or after an experimental trauma (traumatic film viewing) have been shown to reduce subsequent intrusive memories (concurrent or retroactive interference, respectively). This effect is thought to arise because, during the time window of memory consolidation, the film memory is labile and vulnerable to interference by the WM task. However, it is not known whether tasks before an experimental trauma (i...
December 2016: Journal of Behavior Therapy and Experimental Psychiatry
Jessica J Falco-Walter, Michael Stein, Maggie McNulty, Lubov Romantseva, Peter Heydemann
We report a 10-year-old boy with mild developmental delay and epilepsy with new events of right back tickling and emotional upset. These initially appeared behavioral, causing postulation of habit behaviors or psychogenic nonepileptic seizures. Several ictal and interictal EEGs were unrevealing. Continuous EEG revealed only poorly localized frontal ictal activity. Given that his clinical symptoms suggested a parietal localization, double-density EEG electrodes were placed to better localize the epileptogenic and symptomatogenic zones...
2016: Epilepsy & Behavior Case Reports
Claire Anderson, Mohsin A F Khan, Frances Wong, Tatiana Solovieva, Nidia M M Oliveira, Richard A Baldock, Cheryll Tickle, Dave W Burt, Claudio D Stern
Organizers are regions of the embryo that can both induce new fates and impart pattern on other regions. So far, surprisingly few organizers have been discovered, considering the number of patterned tissue types generated during development. This may be because their discovery has relied on transplantation and ablation experiments. Here we describe a new approach, using chick embryos, to discover organizers based on a common gene expression signature, and use it to uncover the anterior intestinal portal (AIP) endoderm as a putative heart organizer...
2016: Nature Communications
Zoe Young, Nima Moghaddam, Anna Tickle
OBJECTIVE: To systematically review the literature on published randomized controlled trials (RCTs) of cognitive behavioral therapy (CBT) for adult ADHD and to establish the effectiveness of CBT in reducing ADHD symptoms. METHOD: A systematic review of nine RCTs and two subsequent meta-analyses of eight of the studies were conducted. RESULTS: Just nine studies were identified, of generally good quality but with some limitations. Four trials (total N = 160) compared CBT with waiting list controls, and three trials (total N = 191) compared CBT with appropriate active control groups...
August 22, 2016: Journal of Attention Disorders
Z Q Liu, J Xia, G L Wang, N Kuermanali
Hyalomma asiaticum tick, an important ectozoic parasite causes tickle, pain, anemia, weight loss, and paralysis in its hosts, which include humans, cattle, sheep, horses, camels, and hares. The 4D8 gene can be a potential vaccine candidate antigen for H. asiaticum. In the present study, we cloned and expressed the 4D8 gene of H. asiaticum from Xinjiang Province. Primers were designed according to the H. asiaticum tick 4D8 gene sequence available in GenBank. The gene was amplified by reverse transcription-polymerase chain reaction and the fragments were subcloned into the prokaryotic expression vector pET30a and the recombinant vector pET30a-4D8 was constructed...
2016: Genetics and Molecular Research: GMR
Sarah D Gunnery, Barbara Habermann, Marie Saint-Hilaire, Cathi A Thomas, Linda Tickle-Degnen
BACKGROUND: Though hypomimia, also called facial masking, is experienced by many people with Parkinson's disease (PD), little is known about how the experience of this motor impairment relates to their own and their care partners' (CP) social life and relationship quality. OBJECTIVE: To test if the experience of facial masking relates to social wellbeing in people with PD and their CPs. METHOD: Forty individuals with PD and their CPs rated PD's difficulty showing facial expression (facial masking), and completed questionnaires about their own social wellbeing and depression...
June 3, 2016: Journal of Parkinson's Disease
Nick Parr, Jackie Li, Leonie Tickle
The economic implications of increasing life expectancy are important concerns for governments in developed countries. The aims of this study were as follows: (i) to forecast mortality for 14 developed countries from 2010 to 2050, using the Poisson Common Factor Model; (ii) to project the effects of the forecast mortality patterns on support ratios; and (iii) to calculate labour force participation increases which could offset these effects. The forecast gains in life expectancy correlate negatively with current fertility...
July 2016: Population Studies
Hui-Ing Ma, Marie Saint-Hilaire, Cathi A Thomas, Linda Tickle-Degnen
PURPOSE: People with Parkinson's disease (PD) may experience stigma due to their visible features of movement and communication difficulties. This paper aimed to examine the role of experienced stigma in health-related quality of life (QOL), after controlling for personal and clinical characteristics. METHODS: This is a preliminary analysis of a subset of baseline data from the Social Self-Management of Parkinson's Disease Study (SocM-PD), an ongoing 3-year prospective cohort study...
June 3, 2016: Quality of Life Research
Terry Ellis, Linda Tickle-Degnen, Marie Saint-Hilaire
No abstract text is available yet for this article.
July 1, 2016: JAMA Neurology
S Sekhar, A Jalligampala, E Zrenner, D L Rathbun
OBJECTIVE: The field of retinal prosthetics has made major progress over the last decade, restoring visual percepts to people suffering from retinitis pigmentosa. The stimulation pulses used by present implants are suprathreshold, meaning individual pulses are designed to activate the retina. In this paper we explore subthreshold pulse sequences as an alternate stimulation paradigm. Subthreshold pulses have the potential to address important open problems such as fading of visual percepts when patients are stimulated at moderate pulse repetition rates and the difficulty in preferentially stimulating different retinal pathways...
August 2016: Journal of Neural Engineering
Joy Tickle
A survey was undertaken with the aim of identifying health professionals' understanding of wound exudate and their ability to assess and manage it. The survey was carried out at Wound Expo, which is a large annual event that provides generalist nurses with interactive education on the core aspects of wound care, including wound exudate. The sample comprised 223 delegates. Almost all delegates (89%) included exudate in every wound assessment, but only 20% based assessment of excess exudate on colour, viscosity and malodour, with the majority (67%) basing it on leakage and increased frequency of dressing changes...
January 28, 2016: British Journal of Nursing: BJN
Oleg Borbulevych, Roger I Martin, Ian J Tickle, Lance M Westerhoff
Gaining an understanding of the protein-ligand complex structure along with the proper protonation and explicit solvent effects can be important in obtaining meaningful results in structure-guided drug discovery and structure-based drug discovery. Unfortunately, protonation and tautomerism are difficult to establish with conventional methods because of difficulties in the experimental detection of H atoms owing to the well known limitations of X-ray crystallography. In the present work, it is demonstrated that semiempirical, quantum-mechanics-based macromolecular crystallographic refinement is sensitive to the choice of a protonation-state/tautomer form of ligands and residues, and can therefore be used to explore potential states...
April 2016: Acta Crystallographica. Section D, Structural Biology
Catarina Vicente
Abigail Tucker is a professor at King's College London, UK and her lab works on various aspects of craniofacial development - from basic, evolutionary and clinical biology perspectives. This year, Abigail will be awarded the first Cheryll Tickle Medal by the British Society for Developmental Biology (BSDB). We chatted with Abigail about her research, her commitment to public engagement and the challenges and rewards of working with emerging model systems.
April 1, 2016: Development
Catarina Vicente
Cheryll Tickle is an Emeritus Professor at the University of Bath, UK. She dedicated her long research career mainly to the study of limb development in the chick, and has received numerous awards for her contributions to science, including being elected a Fellow of The Royal Society and receiving a CBE from the Queen. This year the British Society for Developmental Biology (BSDB) has created a new award in her honour, the Cheryll Tickle Medal, to be awarded to a mid-career, female scientist for outstanding achievements in the field...
April 1, 2016: Development
Kadri Kõiv, Mait Metelitsa, Marten Vares, Kai Tiitsaar, Karita Raudkivi, Külli Jaako, Kaspar Vulla, Ruth Shimmo, Jaanus Harro
The relationship between stress response and positive affective states is thought to be bidirectional: whilst stress can lead to a blunted hedonic response, positive affect reduces the negative effects of stress. We have previously shown that persistently high positive affectivity as measured by 50-kHz ultrasonic vocalizations (USVs) is protective against chronic variable stress (CVS). The present study examined the effect of CVS on 50-kHz USVs elicited by amphetamine administration, simultaneously considering the stable inter-individual differences in positive affectivity...
April 2016: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
Joy Tickle
No abstract text is available yet for this article.
March 2016: British Journal of Community Nursing
Hjalmar S Kühl, Ammie K Kalan, Mimi Arandjelovic, Floris Aubert, Lucy D'Auvergne, Annemarie Goedmakers, Sorrel Jones, Laura Kehoe, Sebastien Regnaut, Alexander Tickle, Els Ton, Joost van Schijndel, Ekwoge E Abwe, Samuel Angedakin, Anthony Agbor, Emmanuel Ayuk Ayimisin, Emma Bailey, Mattia Bessone, Matthieu Bonnet, Gregory Brazolla, Valentine Ebua Buh, Rebecca Chancellor, Chloe Cipoletta, Heather Cohen, Katherine Corogenes, Charlotte Coupland, Bryan Curran, Tobias Deschner, Karsten Dierks, Paula Dieguez, Emmanuel Dilambaka, Orume Diotoh, Dervla Dowd, Andrew Dunn, Henk Eshuis, Rumen Fernandez, Yisa Ginath, John Hart, Daniela Hedwig, Martijn Ter Heegde, Thurston Cleveland Hicks, Inaoyom Imong, Kathryn J Jeffery, Jessica Junker, Parag Kadam, Mohamed Kambi, Ivonne Kienast, Deo Kujirakwinja, Kevin Langergraber, Vincent Lapeyre, Juan Lapuente, Kevin Lee, Vera Leinert, Amelia Meier, Giovanna Maretti, Sergio Marrocoli, Tanyi Julius Mbi, Vianet Mihindou, Yasmin Moebius, David Morgan, Bethan Morgan, Felix Mulindahabi, Mizuki Murai, Protais Niyigabae, Emma Normand, Nicolas Ntare, Lucy Jayne Ormsby, Alex Piel, Jill Pruetz, Aaron Rundus, Crickette Sanz, Volker Sommer, Fiona Stewart, Nikki Tagg, Hilde Vanleeuwe, Virginie Vergnes, Jacob Willie, Roman M Wittig, Klaus Zuberbuehler, Christophe Boesch
The study of the archaeological remains of fossil hominins must rely on reconstructions to elucidate the behaviour that may have resulted in particular stone tools and their accumulation. Comparatively, stone tool use among living primates has illuminated behaviours that are also amenable to archaeological examination, permitting direct observations of the behaviour leading to artefacts and their assemblages to be incorporated. Here, we describe newly discovered stone tool-use behaviour and stone accumulation sites in wild chimpanzees reminiscent of human cairns...
2016: Scientific Reports
Anne-Laure Lemaitre, Marion Luyat, Gilles Lafargue
We assessed self-tickling sensations in a group of participants high in schizotypal traits (n=27) and group of participants low in schizotypal traits (n=27). The groups were formed by screening a pool of 397 students for extreme scores in the French version of the Schizotypal Personality Questionnaire. As observed in a previous study involving psychiatric people with auditory hallucinations and/or passivity experiences our results showed that self-applied tactile stimulations are felt to be more ticklish by healthy individuals high in schizotypal traits...
April 2016: Consciousness and Cognition
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"