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https://www.readbyqxmd.com/read/28099853/a-tissue-mapped-axolotl-de-novo-transcriptome-enables-identification-of-limb-regeneration-factors
#1
Donald M Bryant, Kimberly Johnson, Tia DiTommaso, Timothy Tickle, Matthew Brian Couger, Duygu Payzin-Dogru, Tae J Lee, Nicholas D Leigh, Tzu-Hsing Kuo, Francis G Davis, Joel Bateman, Sevara Bryant, Anna R Guzikowski, Stephanie L Tsai, Steven Coyne, William W Ye, Robert M Freeman, Leonid Peshkin, Clifford J Tabin, Aviv Regev, Brian J Haas, Jessica L Whited
Mammals have extremely limited regenerative capabilities; however, axolotls are profoundly regenerative and can replace entire limbs. The mechanisms underlying limb regeneration remain poorly understood, partly because the enormous and incompletely sequenced genomes of axolotls have hindered the study of genes facilitating regeneration. We assembled and annotated a de novo transcriptome using RNA-sequencing profiles for a broad spectrum of tissues that is estimated to have near-complete sequence information for 88% of axolotl genes...
January 17, 2017: Cell Reports
https://www.readbyqxmd.com/read/27994116/perspectives-on-the-history-of-evo-devo-and-the-contemporary-research-landscape-in-the-genomics-era
#2
Cheryll Tickle, Araxi O Urrutia
A fundamental question in biology is how the extraordinary range of living organisms arose. In this theme issue, we celebrate how evolutionary studies on the origins of morphological diversity have changed over the past 350 years since the first publication of the Philosophical Transactions of The Royal Society Current understanding of this topic is enriched by many disciplines, including anatomy, palaeontology, developmental biology, genetics and genomics. Development is central because it is the means by which genetic information of an organism is translated into morphology...
February 5, 2017: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
https://www.readbyqxmd.com/read/27986921/development-of-a-cancer-marker-activated-enzymatic-switch-from-the-herpes-simplex-virus-thymidine-kinase
#3
Nirav Y Shelat, Sidhartha Parhi, Marc Ostermeier
Discovery of new cancer biomarkers and advances in targeted gene delivery mechanisms have made gene-directed enzyme prodrug therapy (GDEPT) an attractive method for treating cancer. Recent focus has been placed on increasing target specificity of gene delivery systems and reducing toxicity in non-cancer cells in order to make GDEPT viable. To help address this challenge, we have developed an enzymatic switch that confers higher prodrug toxicity in the presence of a cancer marker. The enzymatic switch was derived from the herpes simplex virus thymidine kinase (HSV-TK) fused to the CH1 domain of the p300 protein...
December 15, 2016: Protein Engineering, Design & Selection: PEDS
https://www.readbyqxmd.com/read/27956212/voluntary-ethanol-consumption-changes-anticipatory-ultrasonic-vocalizations-but-not-novelty-response
#4
Erik J Garcia, Emily T Jorgensen, Lukas S Sprick, Mary E Cain
Novelty and sensation seeking (NSS) and affective disorders are correlated with earlier ethanol (ETOH) consumption, and sustained drinking into adulthood. Understanding the NSS response and affective response before and after voluntary ETOH consumption could elucidate important individual differences promoting sustained ETOH consumption. This study determined that NSS and affective response to rewarding stimulation-measured by ultrasonic vocalizations (USVs)-change after adolescent ETOH voluntary drinking. Rats were tested for their NSS response using the inescapable novelty test...
March 1, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/27902721/facial-indicators-of-positive-emotions-in-rats
#5
Kathryn Finlayson, Jessica Frances Lampe, Sara Hintze, Hanno Würbel, Luca Melotti
Until recently, research in animal welfare science has mainly focused on negative experiences like pain and suffering, often neglecting the importance of assessing and promoting positive experiences. In rodents, specific facial expressions have been found to occur in situations thought to induce negatively valenced emotional states (e.g., pain, aggression and fear), but none have yet been identified for positive states. Thus, this study aimed to investigate if facial expressions indicative of positive emotional state are exhibited in rats...
2016: PloS One
https://www.readbyqxmd.com/read/27900823/high-frequency-mechanostimulation-of-cell-adhesion
#6
Laith F Kadem, K Grace Suana, Michelle Holz, Wei Wang, Hannes Westerhaus, Rainer Herges, Christine Selhuber-Unkel
Cell adhesion is regulated by molecularly defined protein interactions and by mechanical forces, which can activate a dynamic restructuring of adhesion sites. Previous attempts to explore the response of cell adhesion to forces have been limited to applying mechanical stimuli that involve the cytoskeleton. In contrast, we here apply a new, oscillatory type of stimulus through push-pull azobenzenes. Push-pull azobenzenes perform a high-frequency, molecular oscillation upon irradiation with visible light that has frequently been applied in polymer surface relief grating...
January 2, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/27884965/-can-you-recommend-any-good-sti-apps-a-review-of-content-accuracy-and-comprehensiveness-of-current-mobile-medical-applications-for-stis-and-related-genital-infections
#7
Jo Gibbs, Voula Gkatzidou, Laura Tickle, Sarah R Manning, Tilna Tilakkumar, Kate Hone, Richard E Ashcroft, Pam Sonnenberg, S Tariq Sadiq, Claudia S Estcourt
OBJECTIVE: Seeking sexual health information online is common, and provision of mobile medical applications (apps) for STIs is increasing. Young people, inherently at higher risk of STIs, are avid users of technology, and apps could be appealing sources of information. We undertook a comprehensive review of content and accuracy of apps for people seeking information about STIs. METHODS: Search of Google Play and iTunes stores using general and specific search terms for apps regarding STIs and genital infections (except HIV), testing, diagnosis and management, 10 September 2014 to 16 September 2014...
November 24, 2016: Sexually Transmitted Infections
https://www.readbyqxmd.com/read/27853620/forward-modelling-the-rubber-hand-illusion-of-ownership-modifies-motor-sensory-predictions-by-the-brain
#8
Laura Aymerich-Franch, Damien Petit, Abderrahmane Kheddar, Gowrishankar Ganesh
The question of how we attribute observed body parts as our own, and the consequences of this attribution on our sensory-motor processes, is fundamental to understand how our brain distinguishes between self and other. Previous studies have identified interactions between the illusion of ownership, and multi-sensory integration and cross-sensory predictions by the brain. Here we show that illusory ownership additionally modifies the motor-sensory predictions by the brain. In our preliminary experiments, we observed a new numbness illusion following the classical rubber-hand illusion (RHI); brushing only the rubber hand after induction of the RHI results in illusory numbness in one's real hand...
August 2016: Royal Society Open Science
https://www.readbyqxmd.com/read/27853216/neuroscience-brain-circuit-for-tickling-found
#9
(no author information available yet)
No abstract text is available yet for this article.
17, 2016: Nature
https://www.readbyqxmd.com/read/27847355/crystal-structure-of-the-marburg-virus-vp35-oligomerization-domain
#10
Jessica F Bruhn, Robert N Kirchdoerfer, Sarah M Urata, Sheng Li, Ian J Tickle, Gérard Bricogne, Erica Ollmann Saphire
: Marburg virus (MARV) is a highly pathogenic filovirus that is classified in a genus distinct from that of Ebola virus (EBOV) (genera Marburgvirus and Ebolavirus, respectively). Both viruses produce a multifunctional protein termed VP35, which acts as a polymerase cofactor, a viral protein chaperone, and an antagonist of the innate immune response. VP35 contains a central oligomerization domain with a predicted coiled-coil motif. This domain has been shown to be essential for RNA polymerase function...
January 15, 2017: Journal of Virology
https://www.readbyqxmd.com/read/27846607/neural-correlates-of-ticklishness-in-the-rat-somatosensory-cortex
#11
S Ishiyama, M Brecht
Rats emit ultrasonic vocalizations in response to tickling by humans. Tickling is rewarding through dopaminergic mechanisms, but the function and neural correlates of ticklishness are unknown. We confirmed that tickling of rats evoked vocalizations, approach, and unsolicited jumps (Freudensprünge). Recordings in the trunk region of the rat somatosensory cortex showed intense tickling-evoked activity in most neurons, whereas a minority of cells were suppressed by tickling. Tickling responses predicted nontactile neural responses to play behaviors, which suggests a neuronal link between tickling and play...
November 11, 2016: Science
https://www.readbyqxmd.com/read/27805067/the-peacock-train-does-not-handicap-cursorial-locomotor-performance
#12
Nathan K Thavarajah, Peter G Tickle, Robert L Nudds, Jonathan R Codd
Exaggerated traits, like the peacock train, are recognized as classic examples of sexual selection. The evolution of sexual traits is often considered paradoxical as, although they enhance reproductive success, they are widely presumed to hinder movement and survival. Many exaggerated traits represent an additional mechanical load that must be carried by the animal and therefore may influence the metabolic cost of locomotion and constrain locomotor performance. Here we conducted respirometry experiments on peacocks and demonstrate that the exaggerated sexually selected train does not compromise locomotor performance in terms of the metabolic cost of locomotion and its kinematics...
November 2, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27798135/physiological-and-perceptual-sensory-attenuation-have-different-underlying-neurophysiological-correlates
#13
Clare E Palmer, Marco Davare, James M Kilner
: Sensory attenuation, the top-down filtering or gating of afferent information, has been extensively studied in two fields: physiological and perceptual. Physiological sensory attenuation is represented as a decrease in the amplitude of the primary and secondary components of the somatosensory evoked potential (SEP) before and during movement. Perceptual sensory attenuation, described using the analogy of a persons' inability to tickle oneself, is a reduction in the perception of the afferent input of a self-produced tactile sensation due to the central cancellation of the reafferent signal by the efference copy of the motor command to produce the action...
October 19, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/27693940/effect-of-stimulus-type-and-temperature-on-eeg-reactivity-in-cardiac-arrest
#14
Tadeu A Fantaneanu, Benjamin Tolchin, Vincent Alvarez, Raymond Friolet, Kathleen Avery, Benjamin M Scirica, Molly O'Brien, Galen V Henderson, Jong Woo Lee
OBJECTIVE: Electroencephalogram (EEG) background reactivity is a reliable outcome predictor in cardiac arrest patients post therapeutic hypothermia. However, there is no consensus on modality testing and prior studies reveal only fair to moderate agreement rates. The aim of this study was to explore different stimulus modalities and report interrater agreements. METHODS: We studied a multicenter, prospectively collected cohort of cardiac arrest patients who underwent therapeutic hypothermia between September 2014 and December 2015...
September 10, 2016: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/27685609/a-randomised-controlled-trial-to-measure-the-effects-and-costs-of-a-dental-caries-prevention-regime-for-young-children-attending-primary-care-dental-services-the-northern-ireland-caries-prevention-in-practice-nic-pip-trial
#15
Martin Tickle, Ciaran O'Neill, Michael Donaldson, Stephen Birch, Solveig Noble, Seamus Killough, Lynn Murphy, Margaret Greer, Julie Brodison, Rejina Verghis, Helen V Worthington
BACKGROUND: Dental caries is the most common disease of childhood. The NHS guidelines promote preventative care in dental practices, particularly for young children. However, the cost-effectiveness of this policy has not been established. OBJECTIVE: To measure the effects and costs of a composite fluoride intervention designed to prevent caries in young children attending dental services. DESIGN: The study was a two-arm, parallel-group, randomised controlled trial, with an allocation ratio of 1 : 1...
September 2016: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/27664818/playing-the-computer-game-tetris-prior-to-viewing-traumatic-film-material-and-subsequent-intrusive-memories-examining-proactive-interference
#16
Ella L James, Alex Lau-Zhu, Hannah Tickle, Antje Horsch, Emily A Holmes
BACKGROUND AND OBJECTIVES: Visuospatial working memory (WM) tasks performed concurrently or after an experimental trauma (traumatic film viewing) have been shown to reduce subsequent intrusive memories (concurrent or retroactive interference, respectively). This effect is thought to arise because, during the time window of memory consolidation, the film memory is labile and vulnerable to interference by the WM task. However, it is not known whether tasks before an experimental trauma (i...
December 2016: Journal of Behavior Therapy and Experimental Psychiatry
https://www.readbyqxmd.com/read/27579251/-tickling-seizures-originating-in-the-left-frontoparietal-region
#17
Jessica J Falco-Walter, Michael Stein, Maggie McNulty, Lubov Romantseva, Peter Heydemann
We report a 10-year-old boy with mild developmental delay and epilepsy with new events of right back tickling and emotional upset. These initially appeared behavioral, causing postulation of habit behaviors or psychogenic nonepileptic seizures. Several ictal and interictal EEGs were unrevealing. Continuous EEG revealed only poorly localized frontal ictal activity. Given that his clinical symptoms suggested a parietal localization, double-density EEG electrodes were placed to better localize the epileptogenic and symptomatogenic zones...
2016: Epilepsy & Behavior Case Reports
https://www.readbyqxmd.com/read/27557800/a-strategy-to-discover-new-organizers-identifies-a-putative-heart-organizer
#18
Claire Anderson, Mohsin A F Khan, Frances Wong, Tatiana Solovieva, Nidia M M Oliveira, Richard A Baldock, Cheryll Tickle, Dave W Burt, Claudio D Stern
Organizers are regions of the embryo that can both induce new fates and impart pattern on other regions. So far, surprisingly few organizers have been discovered, considering the number of patterned tissue types generated during development. This may be because their discovery has relied on transplantation and ablation experiments. Here we describe a new approach, using chick embryos, to discover organizers based on a common gene expression signature, and use it to uncover the anterior intestinal portal (AIP) endoderm as a putative heart organizer...
2016: Nature Communications
https://www.readbyqxmd.com/read/27554190/the-efficacy-of-cognitive-behavioral-therapy-for-adults-with-adhd-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#19
Zoe Young, Nima Moghaddam, Anna Tickle
OBJECTIVE: To systematically review the literature on published randomized controlled trials (RCTs) of cognitive behavioral therapy (CBT) for adult ADHD and to establish the effectiveness of CBT in reducing ADHD symptoms. METHOD: A systematic review of nine RCTs and two subsequent meta-analyses of eight of the studies were conducted. RESULTS: Just nine studies were identified, of generally good quality but with some limitations. Four trials (total N = 160) compared CBT with waiting list controls, and three trials (total N = 191) compared CBT with appropriate active control groups...
August 22, 2016: Journal of Attention Disorders
https://www.readbyqxmd.com/read/27323189/cloning-and-expression-of-the-4d8-gene-from-hyalomma-asiaticum-tick
#20
Z Q Liu, J Xia, G L Wang, N Kuermanali
Hyalomma asiaticum tick, an important ectozoic parasite causes tickle, pain, anemia, weight loss, and paralysis in its hosts, which include humans, cattle, sheep, horses, camels, and hares. The 4D8 gene can be a potential vaccine candidate antigen for H. asiaticum. In the present study, we cloned and expressed the 4D8 gene of H. asiaticum from Xinjiang Province. Primers were designed according to the H. asiaticum tick 4D8 gene sequence available in GenBank. The gene was amplified by reverse transcription-polymerase chain reaction and the fragments were subcloned into the prokaryotic expression vector pET30a and the recombinant vector pET30a-4D8 was constructed...
June 17, 2016: Genetics and Molecular Research: GMR
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