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https://www.readbyqxmd.com/read/29748059/experience-with-the-axillary-artery-as-an-arterial-cannulation-site-in-patients-with-acute-type-a-aortic-dissection
#1
Arpit Talwar, Elvina Wiadji, Manu N Mathur
BACKGROUND: The optimal arterial cannulation site in patients undergoing surgical management of acute type A aortic dissection (ATAAD) remains controversial. The axillary artery is rarely involved in the dissection process, provides antegrade flow in the descending aorta and minimises intraoperative malperfusion. The purpose of this study is to evaluate a single surgeon's experience of axillary artery cannulation for ATAAD repair. METHODS: All consecutive patients over a 15-year period having surgical repair of ATAAD were included in this study...
March 29, 2018: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/29685932/insights-from-the-international-registry-of-acute-aortic-dissection-a-20-year-experience-of-collaborative-clinical-research
#2
REVIEW
Arturo Evangelista, Eric M Isselbacher, Eduardo Bossone, Thomas G Gleason, Marco Di Eusanio, Udo Sechtem, Marek P Ehrlich, Santi Trimarchi, Alan C Braverman, Truls Myrmel, Kevin M Harris, Stuart Hutchinson, Patrick O'Gara, Toru Suzuki, Christoph A Nienaber, Kim A Eagle
Acute aortic dissection (AAD) is a life-threatening condition associated with high morbidity and mortality rates, and it remains a challenge to diagnose and treat. The International Registry of Acute Aortic Dissection was established in 1996 with the mission to raise awareness of this condition and provide insights to guide diagnosis and treatment. Since then, >7300 cases have been included from >51 sites in 12 countries. Although presenting symptoms and physical findings have not changed significantly over this period, the use of computed tomography in the diagnosis has increased, and more patients are managed with interventional procedures: surgery in type A AAD and endovascular therapy in type B AAD; with these changes in care, there has been a significant decrease in overall in-hospital mortality in type A AAD but not in type B AAD...
April 24, 2018: Circulation
https://www.readbyqxmd.com/read/29685689/insulin-resistance-adipocyte-derived-exosomes-aggravate-atherosclerosis-by-increasing-vasa-vasorum-angiogenesis-in-diabetic-apoe-mice
#3
Feng Wang, Fang-Fang Chen, Yuan-Yuan Shang, Ya Li, Zhi-Hao Wang, Lu Han, Yi-Hui Li, Lei Zhang, Yun Ti, Wei Zhang, Ming Zhong
BACKGROUND: Vasa vasorum (VV) angiogenesis is increased in type 2 diabetes mellitus (T2DM) and may promote atherosclerotic plaque rupture. We sought to determine whether insulin resistance adipocyte-derived exosomes (IRADEs) played a major role in modulating VV angiogenesis and the mechanisms involved. METHODS: The characterization of IRADEs was performed by electron microscopy, NTA (Nanoparticle Tracking Analysis) and western blot. The cellular effects of IRADEs on angiogenesis were explored in human umbilical vein endothelial cells (HUVECs) and murine aortic endothelial cells (MAECs) in vitro...
April 9, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29682475/malperfusion-syndromes-in-type-a-aortic-dissection-what-we-have-learned-from-irad
#4
REVIEW
Paolo Berretta, Santi Trimarchi, Himanshu J Patel, Thomas G Gleason, Kim A Eagle, Marco Di Eusanio
Patients presenting with type A acute aortic dissection (TAAD) complicated by malperfusion syndromes represent one of the highest surgical risk cohorts for cardiovascular surgeons. In the setting of aortic dissection, end-organ ischemia may involve any of the major arterial side branches resulting in myocardial, cerebral, spinal cord, visceral and/or limb ischemia. In TAAD patients with malperfusion, notwithstanding continuous improvement in diagnostic and management strategies, surgical and clinical outcomes remain poor and the optimal therapy is controversial...
2018: Journal of Visualized Surgery
https://www.readbyqxmd.com/read/29311417/theoretical-and-experimental-comparison-of-proton-and-helium-beam-radiography-using-silicon-pixel-detectors
#5
T Gehrke, C Amato, S Berke, M Martišíková
Ion-beam radiography (iRad) could potentially improve the quality control of ion-beam therapy. The main advantage of iRad is the possibility to directly measure the integrated stopping power. Until now there is no clinical implementation of iRad. Topics of ongoing research include developing dedicated detection systems to achieve the desired spatial resolution (SR) and investigating different ion types as imaging radiation. This work focuses on the theoretical and experimental comparison of proton (pRad) and helium-beam radiography (αRad)...
February 5, 2018: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29277603/comparing-evolutionary-distances-via-adaptive-distance-functions
#6
Yanir Damti, Ilan Gronau, Shlomo Moran, Irad Yavneh
Distance-based methods for phylogenetic reconstruction are based on a two-step approach: first, pairwise distances are computed from DNA sequences associated with a given set of taxa, and then these distances are used to reconstruct the phylogenetic relationships between taxa. Because the estimated distances are based on finite sequences, they are inherently noisy, and this noise may result in reconstruction errors. Previous attempts to improve reconstruction accuracy focused either on improving the robustness of reconstruction algorithms to this stochastic noise, or on improving the accuracy of the distance estimates...
December 23, 2017: Journal of Theoretical Biology
https://www.readbyqxmd.com/read/29235123/proof-of-principle-of-helium-beam-radiography-using-silicon-pixel-detectors-for-energy-deposition-measurement-identification-and-tracking-of-single-ions
#7
Tim Gehrke, Raya Gallas, Oliver Jäkel, Maria Martišíková
PURPOSE: Hadron therapy has the capability to provide a high dose conformation to tumor regions. However, it requires an accurate target positioning. Thus, the precise monitoring of the patient's anatomical positioning during treatment is desirable. For this purpose, hadron-beam radiography with protons (pRad) and ions (iRad) could be an attractive tool complementing the conventional imaging technologies. On the pathway to an envisaged clinical application, several challenges have to be addressed...
February 2018: Medical Physics
https://www.readbyqxmd.com/read/28879585/the-irad-and-beyond-what-have-we-unravelled-so-far
#8
REVIEW
Xun Yuan, Andreas Mitsis, Yida Tang, Christoph A Nienaber
Acute aortic dissection is a life-threatening condition associated with high morbidity and mortality rates and a long history of challenges to both diagnose and manage this condition successfully. The International Registry of Acute Aortic Dissection (IRAD) was established in 1996 as a global database to understand this old disease better and improve care for dissection. IRAD initially targeted various areas including etiological factors of dissection, modes of presentation, clinical features, physical findings, imaging, management, and outcomes, and is currently branching out in more specific fields such as endovascular intervention, genetic profiling, and functional imaging...
September 6, 2017: General Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28851853/translational-repression-of-the-rpos-antiadapter-irad-by-csra-is-mediated-via-translational-coupling-to-a-short-upstream-open-reading-frame
#9
Hongmarn Park, Louise C McGibbon, Anastasia H Potts, Helen Yakhnin, Tony Romeo, Paul Babitzke
CsrA is a global regulatory RNA binding protein that has important roles in regulating carbon metabolism, motility, biofilm formation, and numerous other cellular processes. IraD functions as an antiadapter protein that inhibits RssB-mediated degradation of RpoS, the general stress response and stationary-phase sigma factor of Escherichia coli Here we identified a novel mechanism in which CsrA represses iraD translation via translational coupling. Expression studies with quantitative reverse transcriptase PCR, Western blotting, and lacZ fusions demonstrated that CsrA represses iraD expression...
August 29, 2017: MBio
https://www.readbyqxmd.com/read/28390915/predictors-of-stable-aortic-dimensions-in-medically-managed-acute-aortic-syndromes
#10
Arnoud V Kamman, Frederik H W Jonker, Udo Sechtem, Kevin M Harris, Arturo Evangelista, Daniel G Montgomery, Himanshu J Patel, Kim A Eagle, Santi Trimarchi
BACKGROUND: We aimed to identify predictors of stable aortic dimensions in medically managed type B aortic dissections (TBAD). METHODS: Medically managed TBAD patients from the International Registry of Acute Aortic Dissection with available aortic measurements at up to 24 months were included. Growth rate was calculated by dividing the largest descending diameter at the latest end point not influenced by intervention minus initial descending diameter, by the recorded time interval...
July 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/28149632/marfan-syndrome-is-the-main-independent-predictor-of-recurrent-aortic-dissection-in-patients-enrolled-in-the-international-registry-of-aortic-dissection-irad
#11
COMMENT
Florian S Schoenhoff, Thierry P Carrel
No abstract text is available yet for this article.
December 2016: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28065489/chronobiology-of-acute-aortic-dissection-in-the-marfan-syndrome-from-the-national-registry-of-genetically-triggered-thoracic-aortic-aneurysms-and-cardiovascular-conditions-and-the-international-registry-of-acute-aortic-dissection
#12
Hasan K Siddiqi, Steven N Luminais, Dan Montgomery, Eduardo Bossone, Harry Dietz, Arturo Evangelista, Eric Isselbacher, Scott LeMaire, Roberto Manfredini, Dianna Milewicz, Christoph A Nienaber, Mary Roman, Udo Sechtem, Michael Silberbach, Kim A Eagle, Reed E Pyeritz
Marfan syndrome (MFS) is an autosomal dominant connective tissue disease associated with acute aortic dissection (AAD). We used 2 large registries that include patients with MFS to investigate possible trends in the chronobiology of AAD in MFS. We queried the International Registry of Acute Aortic Dissection (IRAD) and the Genetically Triggered Thoracic Aortic Aneurysms and Cardiovascular Conditions (GenTAC) registry to extract data on all patients with MFS who had suffered an AAD. The group included 257 patients with MFS who suffered an AAD from 1980 to 2012...
March 1, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/27806642/the-international-registry-of-acute-aortic-dissections-irad-experiences-from-the-first-20-years
#13
Truls Myrmel, Magnus Larsen, Kristian Bartnes
An international collaboration on various aspects of acute aortic syndromes, IRAD or The International Registry of Acute Aortic Dissections, is celebrating its 20th anniversary this year (2016). In this paper, we present important lessons learned during these first 20 years.
October 2016: Scandinavian Cardiovascular Journal: SCJ
https://www.readbyqxmd.com/read/27718275/performance-of-zdock-and-irad-in-capri-rounds-28-34
#14
Thom Vreven, Brian G Pierce, Tyler M Borrman, Zhiping Weng
We report the performance of our protein-protein docking pipeline, including the ZDOCK rigid-body docking algorithm, on 19 targets in CAPRI rounds 28-34. Following the docking step, we reranked the ZDOCK predictions using the IRAD scoring function, pruned redundant predictions, performed energy landscape analysis, and utilized our interface prediction approach RCF. In addition, we applied constraints to the search space based on biological information that we culled from the literature, which increased the chance of making a correct prediction...
March 2017: Proteins
https://www.readbyqxmd.com/read/27587434/recurrent-aortic-dissection-observations-from-the-international-registry-of-aortic-dissection
#15
Eric M Isselbacher, Marc P Bonaca, Marco Di Eusanio, James Froehlich, Eduardo Bassone, Udo Sechtem, Reed Pyeritz, Himanshu Patel, Ali Khoynezhad, Hans-Henning Eckstein, Guillaume Jondeau, Fabio Ramponi, Mohammad Abbasi, Daniel Montgomery, Christoph A Nienaber, Kim Eagle, Mark E Lindsay
BACKGROUND: Improved medical care after initial aortic dissection (AD) has led to increased survivorship and a population of individuals at risk for further cardiovascular events, including recurrent AD. Reports describing recurrent ADs have been restricted to small numbers of patients from single institutions. We used the IRAD (International Registry of Acute Aortic Dissection) database to examine the clinical profiles and outcomes of patients with recurrent AD. METHODS: We identified 204 patients enrolled in IRAD with recurrent AD...
October 4, 2016: Circulation
https://www.readbyqxmd.com/read/27563547/irad-experience-on-surgical-type-a-acute-dissection-patients-results-and-predictors-of-mortality
#16
Paolo Berretta, Himanshu J Patel, Thomas G Gleason, Thoralf M Sundt, Truls Myrmel, Nimesh Desai, Amit Korach, Antonello Panza, Joe Bavaria, Ali Khoynezhad, Elise Woznicki, Dan Montgomery, Eric M Isselbacher, Roberto Di Bartolomeo, Rossella Fattori, Christoph A Nienaber, Kim A Eagle, Santi Trimarchi, Marco Di Eusanio
Type A acute aortic dissection (TAAD) is a disease that has a catastrophic impact on a patient's life and emergent surgery represents a key goal of early treatment. Despite continuous improvements in imaging techniques, medical therapy and surgical management, early mortality in patients undergoing TAAD repair still remains high, ranging from 17% to 26%. In this setting, the International Registry of Acute Aortic Dissection (IRAD), the largest worldwide registry for acute aortic dissection, was established to assess clinical characteristics, management and outcomes of TAAD patients...
July 2016: Annals of Cardiothoracic Surgery
https://www.readbyqxmd.com/read/27424469/impact-of-retrograde-arch-extension-in-acute-type-b-aortic-dissection-on-management-and-outcomes
#17
Foeke J H Nauta, Jip L Tolenaar, Himanshu J Patel, Jehangir J Appoo, Thomas T Tsai, Nimesh D Desai, Daniel G Montgomery, Firas F Mussa, Gilbert R Upchurch, Rosella Fattori, G Chad Hughes, Christoph A Nienaber, Eric M Isselbacher, Kim A Eagle, Santi Trimarchi
BACKGROUND: Optimal management of acute type B aortic dissection with retrograde arch extension is controversial. The effect of retrograde arch extension on operative and long-term mortality has not been studied and is not incorporated into clinical treatment pathways. METHODS: The International Registry of Acute Aortic Dissection was queried for all patients presenting with acute type B dissection and an identifiable primary intimal tear. Outcomes were stratified according to management for patients with and without retrograde arch extension...
December 2016: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/27264225/shock-complicating-type-a-acute-aortic-dissection-clinical-correlates-management-and-outcomes
#18
Eduardo Bossone, Reed E Pyeritz, Alan C Braverman, Mark D Peterson, Marek Ehrlich, Patrick O'Gara, Toru Suzuki, Santi Trimarchi, Dan Gilon, Kevin Greason, Nimesh D Desai, Daniel G Montgomery, Eric M Isselbacher, Christoph A Nienaber, Kim A Eagle
AIMS: Shock is among the most dreaded and common complications of type A acute aortic dissection (TAAAD). However, clinical correlates, management, and short- and long-term outcomes of TAAAD patients presenting with shock in real-world clinical practice are not known. METHODS AND RESULTS: We evaluated 2,704 patients with TAAAD enrolled in the International Registry of Acute Aortic Dissection between January 1, 1996, and August 18, 2012. On admission, 407 (15.1%) TAAAD patients presented with shock...
June 2016: American Heart Journal
https://www.readbyqxmd.com/read/26798680/painless-type-b-aortic-dissection-insights-from-the-international-registry-of-acute-aortic-dissection
#19
Jip L Tolenaar, Stuart J Hutchison, Dan Montgomery, Patrick O'Gara, Rosella Fattori, Reed E Pyeritz, Linda Pape, Toru Suzuki, Arturo Evangelista, Frans L Moll, Vincenzo Rampoldi, Eric M Isselbacher, Cristoph A Nienaber, Kim A Eagle, Santi Trimarchi
INTRODUCTION: The classical presentation of a patient with Type B acute aortic dissection (TBAAD) is characterized by severe chest, back, or abdominal pain, ripping or tearing in nature. However, some patients present with painless acute aortic dissection, which can lead to a delay in diagnosis and treatment. We utilized the International Registry on Acute Aortic Dissections (IRAD) database to study these patients. METHODS: We analyzed 43 painless TBAAD patients enrolled in the database between January 1996 and July 2012...
July 2013: Aorta (Stamford, Conn.)
https://www.readbyqxmd.com/read/26769699/survivors-of-aortic-dissection-activity-mental-health-and-sexual-function
#20
Ashish Chaddha, Eva Kline-Rogers, Alan C Braverman, Steven R Erickson, Elizabeth A Jackson, Barry A Franklin, Elise M Woznicki, Justin T Jabara, Daniel G Montgomery, Kim A Eagle
BACKGROUND: Currently no research exists assessing lifestyle modifications and emotional state of acute aortic dissection (AAD) survivors. We sought to assess activity, mental health, and sexual function in AAD survivors. HYPOTHESIS: Physical and sexual activity will decrease in AAD survivors compared to pre-dissection. Incidence of anxiety and depression will be significant after AAD. METHODS: A cross sectional survey was mailed to 197 subjects from a single academic medical center (part of larger IRAD database)...
November 2015: Clinical Cardiology
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