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Xun Yuan, Andreas Mitsis, Yida Tang, Christoph A Nienaber
Acute aortic dissection is a life-threatening condition associated with high morbidity and mortality rates and a long history of challenges to both diagnose and manage this condition successfully. The International Registry of Acute Aortic Dissection (IRAD) was established in 1996 as a global database to understand this old disease better and improve care for dissection. IRAD initially targeted various areas including etiological factors of dissection, modes of presentation, clinical features, physical findings, imaging, management, and outcomes, and is currently branching out in more specific fields such as endovascular intervention, genetic profiling, and functional imaging...
September 6, 2017: General Thoracic and Cardiovascular Surgery
Hongmarn Park, Louise C McGibbon, Anastasia H Potts, Helen Yakhnin, Tony Romeo, Paul Babitzke
CsrA is a global regulatory RNA binding protein that has important roles in regulating carbon metabolism, motility, biofilm formation, and numerous other cellular processes. IraD functions as an antiadapter protein that inhibits RssB-mediated degradation of RpoS, the general stress response and stationary-phase sigma factor of Escherichia coli Here we identified a novel mechanism in which CsrA represses iraD translation via translational coupling. Expression studies with quantitative reverse transcriptase PCR, Western blotting, and lacZ fusions demonstrated that CsrA represses iraD expression...
August 29, 2017: MBio
Arnoud V Kamman, Frederik H W Jonker, Udo Sechtem, Kevin M Harris, Arturo Evangelista, Daniel G Montgomery, Himanshu J Patel, Kim A Eagle, Santi Trimarchi
BACKGROUND: We aimed to identify predictors of stable aortic dimensions in medically managed type B aortic dissections (TBAD). METHODS: Medically managed TBAD patients from the International Registry of Acute Aortic Dissection with available aortic measurements at up to 24 months were included. Growth rate was calculated by dividing the largest descending diameter at the latest end point not influenced by intervention minus initial descending diameter, by the recorded time interval...
July 2017: Annals of Vascular Surgery
Florian S Schoenhoff, Thierry P Carrel
No abstract text is available yet for this article.
December 2016: Journal of Thoracic Disease
Hasan K Siddiqi, Steven N Luminais, Dan Montgomery, Eduardo Bossone, Harry Dietz, Arturo Evangelista, Eric Isselbacher, Scott LeMaire, Roberto Manfredini, Dianna Milewicz, Christoph A Nienaber, Mary Roman, Udo Sechtem, Michael Silberbach, Kim A Eagle, Reed E Pyeritz
Marfan syndrome (MFS) is an autosomal dominant connective tissue disease associated with acute aortic dissection (AAD). We used 2 large registries that include patients with MFS to investigate possible trends in the chronobiology of AAD in MFS. We queried the International Registry of Acute Aortic Dissection (IRAD) and the Genetically Triggered Thoracic Aortic Aneurysms and Cardiovascular Conditions (GenTAC) registry to extract data on all patients with MFS who had suffered an AAD. The group included 257 patients with MFS who suffered an AAD from 1980 to 2012...
March 1, 2017: American Journal of Cardiology
Truls Myrmel, Magnus Larsen, Kristian Bartnes
An international collaboration on various aspects of acute aortic syndromes, IRAD or The International Registry of Acute Aortic Dissections, is celebrating its 20th anniversary this year (2016). In this paper, we present important lessons learned during these first 20 years.
October 2016: Scandinavian Cardiovascular Journal: SCJ
Thom Vreven, Brian G Pierce, Tyler M Borrman, Zhiping Weng
We report the performance of our protein-protein docking pipeline, including the ZDOCK rigid-body docking algorithm, on 19 targets in CAPRI rounds 28-34. Following the docking step, we reranked the ZDOCK predictions using the IRAD scoring function, pruned redundant predictions, performed energy landscape analysis, and utilized our interface prediction approach RCF. In addition, we applied constraints to the search space based on biological information that we culled from the literature, which increased the chance of making a correct prediction...
March 2017: Proteins
Eric M Isselbacher, Marc P Bonaca, Marco Di Eusanio, James Froehlich, Eduardo Bassone, Udo Sechtem, Reed Pyeritz, Himanshu Patel, Ali Khoynezhad, Hans-Henning Eckstein, Guillaume Jondeau, Fabio Ramponi, Mohammad Abbasi, Daniel Montgomery, Christoph A Nienaber, Kim Eagle, Mark E Lindsay
BACKGROUND: Improved medical care after initial aortic dissection (AD) has led to increased survivorship and a population of individuals at risk for further cardiovascular events, including recurrent AD. Reports describing recurrent ADs have been restricted to small numbers of patients from single institutions. We used the IRAD (International Registry of Acute Aortic Dissection) database to examine the clinical profiles and outcomes of patients with recurrent AD. METHODS: We identified 204 patients enrolled in IRAD with recurrent AD...
October 4, 2016: Circulation
Paolo Berretta, Himanshu J Patel, Thomas G Gleason, Thoralf M Sundt, Truls Myrmel, Nimesh Desai, Amit Korach, Antonello Panza, Joe Bavaria, Ali Khoynezhad, Elise Woznicki, Dan Montgomery, Eric M Isselbacher, Roberto Di Bartolomeo, Rossella Fattori, Christoph A Nienaber, Kim A Eagle, Santi Trimarchi, Marco Di Eusanio
Type A acute aortic dissection (TAAD) is a disease that has a catastrophic impact on a patient's life and emergent surgery represents a key goal of early treatment. Despite continuous improvements in imaging techniques, medical therapy and surgical management, early mortality in patients undergoing TAAD repair still remains high, ranging from 17% to 26%. In this setting, the International Registry of Acute Aortic Dissection (IRAD), the largest worldwide registry for acute aortic dissection, was established to assess clinical characteristics, management and outcomes of TAAD patients...
July 2016: Annals of Cardiothoracic Surgery
Foeke J H Nauta, Jip L Tolenaar, Himanshu J Patel, Jehangir J Appoo, Thomas T Tsai, Nimesh D Desai, Daniel G Montgomery, Firas F Mussa, Gilbert R Upchurch, Rosella Fattori, G Chad Hughes, Christoph A Nienaber, Eric M Isselbacher, Kim A Eagle, Santi Trimarchi
BACKGROUND: Optimal management of acute type B aortic dissection with retrograde arch extension is controversial. The effect of retrograde arch extension on operative and long-term mortality has not been studied and is not incorporated into clinical treatment pathways. METHODS: The International Registry of Acute Aortic Dissection was queried for all patients presenting with acute type B dissection and an identifiable primary intimal tear. Outcomes were stratified according to management for patients with and without retrograde arch extension...
December 2016: Annals of Thoracic Surgery
Eduardo Bossone, Reed E Pyeritz, Alan C Braverman, Mark D Peterson, Marek Ehrlich, Patrick O'Gara, Toru Suzuki, Santi Trimarchi, Dan Gilon, Kevin Greason, Nimesh D Desai, Daniel G Montgomery, Eric M Isselbacher, Christoph A Nienaber, Kim A Eagle
AIMS: Shock is among the most dreaded and common complications of type A acute aortic dissection (TAAAD). However, clinical correlates, management, and short- and long-term outcomes of TAAAD patients presenting with shock in real-world clinical practice are not known. METHODS AND RESULTS: We evaluated 2,704 patients with TAAAD enrolled in the International Registry of Acute Aortic Dissection between January 1, 1996, and August 18, 2012. On admission, 407 (15.1%) TAAAD patients presented with shock...
June 2016: American Heart Journal
Jip L Tolenaar, Stuart J Hutchison, Dan Montgomery, Patrick O'Gara, Rosella Fattori, Reed E Pyeritz, Linda Pape, Toru Suzuki, Arturo Evangelista, Frans L Moll, Vincenzo Rampoldi, Eric M Isselbacher, Cristoph A Nienaber, Kim A Eagle, Santi Trimarchi
INTRODUCTION: The classical presentation of a patient with Type B acute aortic dissection (TBAAD) is characterized by severe chest, back, or abdominal pain, ripping or tearing in nature. However, some patients present with painless acute aortic dissection, which can lead to a delay in diagnosis and treatment. We utilized the International Registry on Acute Aortic Dissections (IRAD) database to study these patients. METHODS: We analyzed 43 painless TBAAD patients enrolled in the database between January 1996 and July 2012...
July 2013: Aorta (Stamford, Conn.)
Ashish Chaddha, Eva Kline-Rogers, Alan C Braverman, Steven R Erickson, Elizabeth A Jackson, Barry A Franklin, Elise M Woznicki, Justin T Jabara, Daniel G Montgomery, Kim A Eagle
BACKGROUND: Currently no research exists assessing lifestyle modifications and emotional state of acute aortic dissection (AAD) survivors. We sought to assess activity, mental health, and sexual function in AAD survivors. HYPOTHESIS: Physical and sexual activity will decrease in AAD survivors compared to pre-dissection. Incidence of anxiety and depression will be significant after AAD. METHODS: A cross sectional survey was mailed to 197 subjects from a single academic medical center (part of larger IRAD database)...
November 2015: Clinical Cardiology
Linda A Pape, Mazen Awais, Elise M Woznicki, Toru Suzuki, Santi Trimarchi, Arturo Evangelista, Truls Myrmel, Magnus Larsen, Kevin M Harris, Kevin Greason, Marco Di Eusanio, Eduardo Bossone, Daniel G Montgomery, Kim A Eagle, Christoph A Nienaber, Eric M Isselbacher, Patrick O'Gara
BACKGROUND: Diagnosis, treatment, and outcomes of acute aortic dissection (AAS) are changing. OBJECTIVES: This study examined 17-year trends in the presentation, diagnosis, and hospital outcomes of AAD from the International Registry of Acute Aortic Dissection (IRAD). METHODS: Data from 4,428 patients enrolled at 28 IRAD centers between December 26, 1995, and February 6, 2013, were analyzed. Patients were divided according to enrollment date into 6 equal groups and by AAD type: A (n = 2,952) or B (n = 1,476)...
July 28, 2015: Journal of the American College of Cardiology
Javier S Turek, Michael Elad, Irad Yavneh
In ultrasound imaging, clutter artifacts degrade images and may cause inaccurate diagnosis. In this paper, we apply a method called Morphological Component Analysis (MCA) for sparse signal separation with the objective of reducing such clutter artifacts. The MCA approach assumes that the two signals in the additive mix have each a sparse representation under some dictionary of atoms (a matrix), and separation is achieved by finding these sparse representations. In our work, an adaptive approach is used for learning the dictionary from the echo data...
2015: International Journal of Biomedical Imaging
Yangyang Ge, Shangwei Zuo, Wei Guo, Jiang Xiong, Xin Jia, Xiaozhong Hu, Qinghua Xu, Xiaoping Liu
OBJECTIVE: To establish the ultrasonographic criteria for normal size of infrarenal aorta (IRA) and common iliac arteries (CIA) of young males in a Chinese school and to determine the associations between IRA diameter (IRAD) and CIA diameter (CIAD) and body habitus as well as traditional cardiovascular risk factors. METHODS: Cross-sectional study was done of 203 Chinese young males enrolled from a technical school in Beijing Changping district from May to June 2013...
May 2015: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
Dimce Micevski, Jessica E Zammit, Kaye N Truscott, David A Dougan
In Escherichia coli, σ(S) is the master regulator of the general stress response. The level of σ(S) changes in response to multiple stress conditions and it is regulated at many levels including protein turnover. In the absence of stress, σ(S) is rapidly degraded by the AAA+ protease, ClpXP in a regulated manner that depends on the adaptor protein RssB. This two-component response regulator mediates the recognition of σ(S) and its delivery to ClpXP. The turnover of σ(S) however, can be inhibited in a stress specific manner, by one of three anti-adaptor proteins...
2015: Frontiers in Molecular Biosciences
Philipp A Ilinykh, Ndongala M Lubaki, Steven G Widen, Lynnsey A Renn, Terence C Theisen, Ronald L Rabin, Thomas G Wood, Alexander Bukreyev
UNLABELLED: Ebola virus (EBOV) causes a severe hemorrhagic fever with a deficient immune response, lymphopenia, and lymphocyte apoptosis. Dendritic cells (DC), which trigger the adaptive response, do not mature despite EBOV infection. We recently demonstrated that DC maturation is unblocked by disabling the innate response antagonizing domains (IRADs) in EBOV VP35 and VP24 by the mutations R312A and K142A, respectively. Here we analyzed the effects of VP35 and VP24 with the IRADs disabled on global gene expression in human DC...
August 2015: Journal of Virology
Mislav Vrsalovic, Ivan Zeljkovic, Ana Vrsalovic Presecki, Hrvoje Pintaric, Bozo Kruslin
BACKGROUND: The aim of the study was to evaluate prognostic role of inflammatory biomarkers, cardiac troponin T (cTnT) and D-dimer in type A acute aortic dissection (AAD) and to examine whether they might help in risk stratification beyond values of International Registry of Acute Aortic Dissection (IRAD) score. METHODS: Baseline biomarkers were determined in 54 consecutive predominantly hypertensive patients with type A AAD and evaluated for in-hospital mortality...
2015: Blood Pressure
Aurelia Battesti, Nadim Majdalani, Susan Gottesman
RpoS, the stationary phase/stress sigma factor of Escherichia coli, regulates a large cohort of genes important for the cell to deal with suboptimal conditions. Its level increases quickly in the cell in response to many stresses and returns to low levels when growth resumes. Increased RpoS results from increased translation and decreased RpoS degradation. Translation is positively regulated by small RNAs (sRNAs). Protein stability is positively regulated by anti-adaptors, which prevent the RssB adaptor-mediated degradation of RpoS by the ClpXP protease...
April 21, 2015: Proceedings of the National Academy of Sciences of the United States of America
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