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JOURNAL ARTICLE
Yotam Dery, Matan Yechezkel, Irad Ben-Gal, Dan Yamin
Current global COVID-19 booster scheduling strategies mainly focus on vaccinating high-risk populations at predetermined intervals. However, these strategies overlook key data: the direct insights into individual immunity levels from active serological testing and the indirect information available either through sample-based sero-surveillance, or vital demographic, location, and epidemiological factors. Our research, employing an age-, risk-, and region-structured mathematical model of disease transmission-based on COVID-19 incidence and vaccination data from Israel between 15 May 2020 and 25 October 2021-reveals that a more comprehensive strategy integrating these elements can significantly reduce COVID-19 hospitalizations without increasing existing booster coverage...
April 6, 2024: Scientific Reports
#2
JOURNAL ARTICLE
Axillary vs Femoral Arterial Cannulation in Acute Type A Dissection: International Multicenter Data.
Malak Elbatarny, Santi Trimarchi, Amit Korach, Marco Di Eusanio, Davide Pacini, Raffi Bekeredjian, Truls Myrmel, Joseph E Bavaria, Nimesh D Desai, Ibrahim Sultan, Derek R Brinster, Chih-Wen Pai, Kim A Eagle, Himanshu J Patel, Mark D Peterson
BACKGROUND: Cannulation strategy in acute Type A dissection (ATAD) varies widely without known gold standards. We compared ATAD outcomes of Axillary versus Femoral cannulation in a large cohort from the International Registry of Acute Aortic Dissection (IRAD). METHODS: We retrospectively reviewed 2145 IRAD Interventional Cohort patients (1996-2021) undergoing ATAD repair with axillary or femoral cannulation (Axillary: N=1106, 52%; Femoral: N=1039, 48%). Endpoints included: early mortality; neurologic, respiratory and renal complications; malperfusion; and tamponade...
March 6, 2024: Annals of Thoracic Surgery
#3
JOURNAL ARTICLE
Francesco Pollari, Paolo Nardi, Elisa Mikus, Francesco Ferraro, Marco Gemelli, Ilaria Franzese, Ilaria Chirichilli, Claudia Romagnoni, Giuseppe Santarpino, Salvatore Nicolardi, Roberto Scrofani, Francesco Musumeci, Enzo Mazzaro, Gino Gerosa, Massimo Massetti, Carlo Savini, Giovanni Ruvolo, Michele Di Mauro, Luca Di Marco, Fabio Barili, Alessandro Parolari, Theodor Fischlein
OBJECTIVES: In last decades, 4 different scores for prediction of mortality following surgery for type A acute aortic dissection (TAAD) were proposed. We aimed to validate these scores in a large external multicentre cohort. METHODS: We retrospectively analyzed patients who underwent surgery for TAAD between 2000 and 2020. Patients were enrolled from 10 centers from 2 European countries. Outcomes were the early (30-days and/or in-hospital), and 1-year mortality...
January 11, 2024: European Journal of Cardio-thoracic Surgery
#4
JOURNAL ARTICLE
Yasunori Iida
The International Registry of Aortic Dissection (IRAD) reported that the incidence of limb ischemia in Stanford type A aortic dissection( TAAD) was 17%. The incidence of lower limb ischemia in Stanford type B aortic dissection( TBAD) ranged from 5.7% to 30.0%, and in-hospital mortality was high in patients with lower limb ischemia complications. The reasons for this are:ischemia of other organs, especially intestinal ischemia, often coexists in patients with lower limb ischemia, resulting in a high incidence of myonephropathic metabolic syndrome (MNMS);thoracic aortic open surgery is often prioritized under the concept of central repair, and prolonged lower limb ischemia time results in compartmentalization due to ischemia-reperfusion injury...
September 2023: Kyobu Geka. the Japanese Journal of Thoracic Surgery
#5
JOURNAL ARTICLE
Lianfeng Lu, Yanan Ma, Yang Cong, Baotong Zhou, Yeye Chen, Jingwen Niu, Yun He, Wei Cao, Taisheng Li
BACKGROUND: Comorbidity of Myasthenia gravis (MG) and Graves' disease (GD) in treated HIV-infected individuals has rarely been described and little study has been done on the link between HIV-related immune reconstitution and autoimmune diseases occurring post antiretroviral therapy. CASE PRESENTATION: Here we report on a 33-year-old Chinese man with HIV infection who had been virologically suppressed since 2018. The patient was diagnosed with GD and was treated in 2020...
November 22, 2023: HIV Medicine
#6
JOURNAL ARTICLE
Christiane Brugger, Jacob Schwartz, Scott Novick, Song Tong, Joel Hoskins, Nadim Majdalani, Rebecca Kim, Martin Filipovski, Sue Wickner, Susan Gottesman, Patrick Griffin, Alexandra M Deaconescu
In enterobacteria such as Escherichia coli, the general stress response is mediated by σs , the stationary phase dissociable promoter specificity subunit of RNA polymerase. σs is degraded by ClpXP during active growth in a process dependent on the RssB adaptor, which is thought to be stimulated by phosphorylation of a conserved aspartate in its N-terminal receiver domain. Here we present the crystal structure of full-length RssB bound to a beryllofluoride phosphomimic. Compared to the structure of RssB bound to the IraD anti-adaptor, our new RssB structure with bound beryllofluoride reveals conformational differences and coil-to-helix transitions in the C-terminal region of the RssB receiver domain and in the inter-domain segmented helical linker...
November 8, 2023: Journal of Biological Chemistry
#7
Nikita S D Sahadeo, Soren Nicholls, Filipe R R Moreira, Áine O'Toole, Vernie Ramkissoon, Charles Whittaker, Verity Hill, John T McCrone, Nicholas Mohammed, Anushka Ramjag, Arianne Brown Jordan, Sarah C Hill, Risha Singh, Sue-Min Nathaniel-Girdharrie, Avery Hinds, Nuala Ramkissoon, Kris V Parag, Naresh Nandram, Roshan Parasram, Zobida Khan-Mohammed, Lisa Edghill, Lisa Indar, Aisha Andrewin, Rhonda Sealey-Thomas, Pearl McMillan, Ayoola Oyinloye, Kenneth George, Irad Potter, John Lee, David Johnson, Shawn Charles, Narine Singh, Jacquiline Bisesor-McKenzie, Hazel Laws, Sharon Belmar-George, Simone Keizer-Beache, Sharra Greenaway-Duberry, Nadia Ashwood, Jerome E Foster, Karla Georges, Rahul Naidu, Marsha Ivey, Stanley Giddings, Rajini Haraksingh, Adesh Ramsubhag, Jayaraj Jayaraman, Chinnaraja Chinnadurai, Christopher Oura, Oliver G Pybus, Joy St John, Gabriel Gonzalez-Escobar, Nuno R Faria, Christine V F Carrington
[This corrects the article DOI: 10.1371/journal.pgph.0001455.].
2023: PLOS Glob Public Health
#8
JOURNAL ARTICLE
Santi Trimarchi, Tim J Mandigers, Daniele Bissacco, Christoph Nienaber, Eric M Isselbacher, Arturo Evangelista, Toru Suzuki, Eduardo Bossone, Linda A Pape, James L Januzzi, Kevin M Harris, Patrick T O'Gara, Dan Gilon, Stuart Hutchison, Himanshu J Patel, Elise M Woznicki, Daniel Montgomery, Eva Kline-Rogers, Kim A Eagle
OBJECTIVE: The International Registry of Acute Aortic Dissection (IRAD) celebrated its 25th anniversary in January 2021. This study evaluated IRAD's role in promoting the understanding and management of acute aortic dissection (AD) over these years. METHODS: IRAD studies were identified, analyzed, and ranked according to their citations per year (c/y) to determine the most-cited IRAD studies and topics. A systematic search of the literature identified cardiovascular guidelines on the diagnosis and management of acute AD...
July 13, 2023: Journal of Thoracic and Cardiovascular Surgery
#9
JOURNAL ARTICLE
Nikita S D Sahadeo, Soren Nicholls, Filipe R R Moreira, Áine O'Toole, Vernie Ramkissoon, Charles Whittaker, Verity Hill, John T McCrone, Nicholas Mohammed, Anushka Ramjag, Arianne Brown Jordan, Sarah C Hill, Risha Singh, Sue-Min Nathaniel-Girdharrie, Avery Hinds, Nuala Ramkissoon, Kris V Parag, Naresh Nandram, Roshan Parasram, Zobida Khan-Mohammed, Lisa Edghill, Lisa Indar, Aisha Andrewin, Rhonda Sealey-Thomas, Pearl McMillan, Ayoola Oyinloye, Kenneth George, Irad Potter, John Lee, David Johnson, Shawn Charles, Narine Singh, Jacquiline Bisesor-McKenzie, Hazel Laws, Sharon Belmar-George, Simone Keizer-Beache, Sharra Greenaway-Duberry, Nadia Ashwood, Jerome E Foster, Karla Georges, Rahul Naidu, Marsha Ivey, Stanley Giddings, Rajini Haraksingh, Adesh Ramsubhag, Jayaraj Jayaraman, Chinnaraja Chinnadurai, Christopher Oura, Oliver G Pybus, Joy St John, Gabriel Gonzalez-Escobar, Nuno R Faria, Christine V F Carrington
The COVID-19 pandemic highlighted the importance of global genomic surveillance to monitor the emergence and spread of SARS-CoV-2 variants and inform public health decision-making. Until December 2020 there was minimal capacity for viral genomic surveillance in most Caribbean countries. To overcome this constraint, the COVID-19: Infectious disease Molecular epidemiology for PAthogen Control & Tracking (COVID-19 IMPACT) project was implemented to establish rapid SARS-CoV-2 whole genome nanopore sequencing at The University of the West Indies (UWI) in Trinidad and Tobago (T&T) and provide needed SARS-CoV-2 sequencing services for T&T and other Caribbean Public Health Agency Member States (CMS)...
2023: PLOS Glob Public Health
#10
Kirandeep Gill, Carolina Moore, Onyekachi Nwogu, John W Kroner, Wan-Chi Chang, Mariana L Stevens, Asel Baatyrbek Kyzy, Jocelyn M Biagini, Ashley L Devonshire, Leah Kottyan, Justin T Schwartz, Amal H Assaâ Ad, Lisa J Martin, Sandra Andorf, Gurjit K Khurana Hershey, Krishna M Roskin
UNLABELLED: The skin is a major immune organ and skin barrier dysfunction is a major risk factor for the development of the inappropriate immune response seen in allergic disease. Skin barrier disruption alters the landscape of antigens experienced by the immune system and the downstream impacts on the antibody repertoire remain poorly characterized, particularly for the IgE isotype responsible for allergic specificity and in early life, when allergic disease is developing. In this study, we sequenced antibody gene repertoires from a large and well-characterized cohort of children with atopic dermatitis and found that food sensitization was associated with lower mutation frequencies in the IgE compartment...
February 3, 2023: bioRxiv
#11
JOURNAL ARTICLE
Vishnu M Chandra, Elizabeth L Norton, Minhaj S Khaja, Daniel Giraldo Herrera, David M Williams, Bo Yang
OBJECTIVES: Mesenteric malperfusion is a feared complication of aortic dissection, with high mortality. The purpose of this study was to systematically review in-hospital mortality (IHM) of endovascular and surgical management of acute and chronic Stanford type B aortic dissections (TBAD) complicated by mesenteric malperfusion (MesMP). METHODS: A systematic search of English language articles was conducted in relevant databases. Data on patient demographics, procedure details, and survival outcomes were collected...
December 2022: JTCVS open
#12
JOURNAL ARTICLE
George J Arnaoutakis, Takuya Ogami, Himanshu J Patel, Chih-Wen Pai, Elise M Woznicki, Derek R Brinster, Bradley G Leshnower, Derek Serna-Gallegos, Raffi Bekeredjian, Thoralf M Sundt, Andrew W Shaffer, Mark D Peterson, Guillaume S C Geuzebroek, Kim A Eagle, Santi Trimarchi, Ibrahim Sultan
BACKGROUND: Acute kidney injury (AKI) following repair of type A acute aortic dissection (TAAAD) has been shown to affect both short- and long-term outcomes. This study aimed to validate the impact of post-operative AKI on in-hospital and long-term outcomes in a large population of dissection patients presenting to multinational aortic centers. Additionally, we assessed risk factors for AKI including surgical details. METHODS: Patients undergoing surgical repair for TAAAD enrolled in the International Registry of Acute Aortic Dissection database were evaluated to determine the incidence and risk factors for the development of AKI...
November 9, 2022: Annals of Thoracic Surgery
#13
JOURNAL ARTICLE
Stanley B Wolfe, Thoralf M Sundt, Eric M Isselbacher, Duke E Cameron, Santi Trimarchi, Raffi Bekeredjian, Bradley Leshnower, Joseph E Bavaria, Derek R Brinster, Ibrahim Sultan, Chih-Wen Pai, Puja Kachroo, Maral Ouzounian, Joseph S Coselli, Truls Myrmel, Davide Pacini, Kim Eagle, Himanshu J Patel, Arminder S Jassar
OBJECTIVE: Approximately one-quarter of patients with acute type A aortic dissection (TAAD) present with concomitant malperfusion of coronary arteries, mesenteric circulation, lower extremities, kidneys, brain, and/or coma. It is generally accepted that TAAD patients who present with malperfusion experience higher mortality rates than patients without, although how specific malperfusion syndromes, alone or in combination, affect mortality is not well described. METHODS: The International Registry of Acute Aortic Dissection database was queried for patients who underwent surgical repair of TAAD...
September 29, 2022: Journal of Thoracic and Cardiovascular Surgery
#14
JOURNAL ARTICLE
Obafemi Ibitayo Obajemihi, Jun-Hu Cheng, Da-Wen Sun
Infrared drying (IRD) is considered an innovative drying solution for the food industry with advantages of energy-saving potentials, reduced drying time and production cost-effectiveness. However, IRD also suffers from drawbacks such as weak penetrative ability, and product overheating and burning. Therefore, over the years, significant progress has been made to overcome these shortcomings by developing infrared-accelerated drying (IRAD) technology based on the combination of IRD with other drying technologies...
October 14, 2022: Critical Reviews in Food Science and Nutrition
#15
JOURNAL ARTICLE
Michael A Catalano, Tania Mamdouhi, Stevan Pupovac, Kevin F Kennedy, Derek R Brinster, Alan Hartman, Pey-Jen Yu
Objective: Acute type A aortic dissection (ATAAD) is a surgical emergency with significant morbidity and mortality, as well as significant center-level variation in outcomes. Our study aims to leverage a nationally representative database to assess contemporary in-hospital outcomes in surgical repair of ATAAD, as well as the association of age and sex with outcomes. Methods: The National Inpatient Sample was queried to identify hospital discharge records of patients aged ≥18 years who underwent urgent surgical repair of ATAAD between 2017 and 2018...
September 2022: JTCVS open
#16
JOURNAL ARTICLE
Yuval Shalev, Amichai Painsky, Irad Ben-Gal
Estimating the entropy of a discrete random variable is a fundamental problem in information theory and related fields. This problem has many applications in various domains, including machine learning, statistics, and data compression. Over the years, a variety of estimation schemes have been suggested. However, despite significant progress, most methods still struggle when the sample is small, compared to the variable's alphabet size. In this work, we introduce a practical solution to this problem, which extends the work of McAllester and Statos...
September 26, 2022: IEEE Transactions on Neural Networks and Learning Systems
#17
JOURNAL ARTICLE
Barouch Matzliach, Irad Ben-Gal, Evgeny Kagan
This paper addresses the problem of detecting multiple static and mobile targets by an autonomous mobile agent acting under uncertainty. It is assumed that the agent is able to detect targets at different distances and that the detection includes errors of the first and second types. The goal of the agent is to plan and follow a trajectory that results in the detection of the targets in a minimal time. The suggested solution implements the approach of deep Q-learning applied to maximize the cumulative information gain regarding the targets' locations and minimize the trajectory length on the map with a predefined detection probability...
August 22, 2022: Entropy
#18
JOURNAL ARTICLE
Amer Harky, Sabrina Mason, Ahmed Othman, Matthew Shaw, Omar Nawaytou, Deborah Harrington, Manoj Kuduvalli, Mark Field
Objective: We sought to report our experience of repairing acute type A aortic dissection (ATAAD) over 21 years during in-hours versus out-of-hours before and after the establishment of specialized aortic service and rota. Methods: A retrospective analysis of all patients who had ATAAD repair between November 1998 and December 2019 in our center. In-hours were defined as 08:00 to 19:59 hours and out of hours were defined as 20:00 to 07:59 hours. Results: A total of 286 patients underwent repair of ATAAD...
September 2021: JTCVS open
#19
JOURNAL ARTICLE
Ian F Walker, Laura Asher, Anees Pari, Jennifer Attride-Stirling, Ayoola O Oyinloye, Chantelle Simmons, Irad Potter, Virginia Rubaine, June M Samuel, Aisha Andrewin, Janett Flynn, Arline L McGill, Sharra Greenaway-Duberry, Alicia B Malcom, Gemma Mann, Ahmed Razavi, Roger C Gibson
BACKGROUND: Small island developing states (SIDS) have particular mental health system needs due to their remoteness and narrow resource base. We conducted situational analyses to support mental health system strengthening in six SIDS: Anguilla, Bermuda, British Virgin Islands, Cayman Islands, Montserrat and Turks and Caicos Islands. METHODS: The situational analyses covered five domains: 1. Socio-economic context and burden of mental disorders, 2. Leadership and governance for mental health 3...
August 12, 2022: International Journal of Mental Health Systems
#20
JOURNAL ARTICLE
C Knobloch, M Metzner, F Kehrein, C Schömers, S Scheloske, S Brons, R Hermann, A Peters, O Jäkel, M Martišíková, T Gehrke
PURPOSE: A clinical implementation of ion-beam radiography (iRad) is envisaged to provide a method for on-couch verification of ion-beam treatment plans. The aim of this work is to introduce and evaluate a method for quantitative water-equivalent thickness (WET) measurements for a specific helium-ion imaging system for WETs that are relevant for imaging thicker body parts in the future. METHODS: Helium-beam radiographs (αRads) are measured at the Heidelberg Ion-beam Therapy Center (HIT) with an initial beam energy of 239...
June 6, 2022: Medical Physics
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