keyword
https://read.qxmd.com/read/38530825/application-of-covalent-binding-body-burden-in-the-h%C3%AE-rel-human-hepatocyte-coculture-model-for-reactivity-risk-assessment-of-metabolically-low-turnover-drugs
#1
JOURNAL ARTICLE
Jackie Shang, Kevin J Coe, Heng Keang Lim, Lu Chen, Buddha B Khatri, Rhys Salter, Kaushik Mitra, Ramaswamy Iyer
The human hepatocyte suspension model has been a valuable tool to study covalent binding (CVB) for compounds that form reactive metabolites. However, accurately measuring CVB values with the suspension model becomes challenging for metabolically low turnover compounds. In this study, we evaluated the HμREL human hepatocyte coculture model relative to existing literature using human hepatocyte suspension for drugs of known drug-induced liver injury category. Our results indicate that this coculture model provides ample metabolic turnover to reproducibly measure CVB...
March 26, 2024: Chemical Research in Toxicology
https://read.qxmd.com/read/38530432/chemotherapy-initiated-cysteine-rich-protein-61-decreases-acute-b-lymphoblastic-leukemia-chemosensitivity
#2
JOURNAL ARTICLE
Pengchong Shi, Zhen Lin, Yanfang Song, Zhaozhong Li, Menglu Zeng, Li Luo, Yingping Cao, Xianjin Zhu
PURPOSE: Chemoresistance is a major challenge for acute lymphoblastic leukemia (ALL) treatment. Cysteine-rich protein 61 (Cyr61) plays an important role in drug resistance modulation of tumor cells, and Cyr61 levels are increased in the bone marrow of patients with ALL and contribute to ALL cell survival. However, the effect of Cyr61 on B cell acute lymphoblastic leukemia (B-ALL) cell chemosensitivity and the regulatory mechanisms underlying Cyr61 production in bone marrow remain unknown...
March 26, 2024: Journal of Cancer Research and Clinical Oncology
https://read.qxmd.com/read/38530272/individualized-digitally-designed-surgical-template-for-guided-soft-tissue-surgery-in-cases-with-severe-gingival-enlargement-a-clinical-application-in-hereditary-gingival-fibromatosis
#3
JOURNAL ARTICLE
Maria Sykara, Panagiotis Ntovas, Nikolaos Markou, Phoebus Madianos, Spyridon Vassilopoulos
AIM: The purpose of this study was to present the use of computer-assisted periodontal surgery utilizing a novel surgical guide for cases with severe gingival enlargement through a clinical application in a patient with hereditary gingival fibromatosis. MATERIALS AND METHODS: The treatment plan included nonsurgical periodontal therapy, surgical periodontal treatment, and regular periodontal maintenance before the initiation of orthodontic treatment. Due to the increased soft tissue thickness, a surgical guide with a novel design was fabricated to facilitate the periodontal surgery since most of the patient's teeth were malpositioned and underexposed due to fibromatosis...
March 26, 2024: International Journal of Computerized Dentistry
https://read.qxmd.com/read/38529960/correction-for-huang-et-al-chemotherapeutic-drugs-induce-different-gut-microbiota-disorder-pattern-and-nod-rip2-nf-%C3%AE%C2%BAb-signaling-pathway-activation-that-lead-to-different-degrees-of-intestinal-injury
#4
JOURNAL ARTICLE
Bin Huang, Mengxuan Gui, Zhuona Ni, Yanbin He, Jinyan Zhao, Jun Peng, Jiumao Lin
No abstract text is available yet for this article.
March 26, 2024: Microbiology Spectrum
https://read.qxmd.com/read/38529697/has-the-rescheduling-of-modified-release-paracetamol-in-australia-affected-the-frequency-of-overdoses
#5
JOURNAL ARTICLE
Michaela J Ryan, Andis Graudins, Nicole O'Shea, Firouzeh Noghrehchi, Anselm Wong
OBJECTIVES: In June 2020, modified-release paracetamol (paracetamol-MR) preparations were up-scheduled from schedule-2 (available in pharmacy) to schedule-3 (available by request to a pharmacist only). The present study aims to ascertain whether up-scheduling affected the frequency of paracetamol-MR overdoses. METHODS: This is a retrospective cohort study of two data sets from 1 June 2017 to 31 May 2022. Monash Health data were extracted using the diagnosis of paracetamol overdose coding and electronic medical records data...
March 26, 2024: Emergency Medicine Australasia: EMA
https://read.qxmd.com/read/38529465/a-case-report-of-neuro-beh%C3%A3-et-syndrome-frequent-neurological-manifestations-concurrent-with-life-threatening-illnesses
#6
Omar Ballut, Mayas M Almahi, Banan S Alghamdi, Najla K Alzahrani, Maali A Alghamdi
​​​​Behçet disease (BD) is a recurrent, multisystemic autoimmune vasculitis that affects both small and large vessels. A combination of neurological signs and symptoms in BD is called neuro-Behçet syndrome (NBS). We present the case of a 31-year-old male diagnosed with chronic progressive NBS who presented with multiple relapsing episodes concurrent with infective endocarditis due to intravenous drug abuse, drug-induced hepatitis, acute kidney injury, and septic shock that is not related to BD...
February 2024: Curēus
https://read.qxmd.com/read/38529375/case-report-a-case-of-metastatic-brafv600-mutated-melanoma-with-heart-failure-treated-with-immune-checkpoint-inhibitors-and-braf-mek-inhibitors
#7
Aya Nishizawa, Misaki Kawakami, Yasuyuki Kitahara
BACKGROUND: Novel therapies, immune checkpoint inhibitors (ICIs), and BRAF/MEK inhibitors (BRAFi/MEKi) provide unprecedented survival benefits for patients with advanced melanoma. However, the management of drug-induced adverse events is problematic for both agents and, although rare, can cause serious cardiac dysfunction. CASE REPORT: A 42-year-old male patient with no significant medical history noticed a fading dark brown patch on his left anterior chest, which had been there for 20 years, after his second coronavirus disease 2019 (COVID-19) vaccination...
2024: Frontiers in Oncology
https://read.qxmd.com/read/38528719/difference-in-the-mechanism-of-iron-overload-enhanced-acute-hepatotoxicity-induced-by-thioacetamide-and-carbon-tetrachloride-in-rats
#8
JOURNAL ARTICLE
Yohei Inai, Takeshi Izawa, Tomomi Kamei, Sho Fujiwara, Miyuu Tanaka, Jyoji Yamate, Mitsuru Kuwamura
Iron overload has been recognized as a risk factor for liver disease; however, little is known about its pathological role in the modification of liver injury. The purpose of this study is to investigate the influence of iron overload on liver injury induced by two hepatotoxicants with different pathogenesis in rats. Rats were fed a control (Cont), 0.8% high-iron (0.8% Fe), or 1% high-iron diet (1% Fe) for 4 weeks and were then administered with saline, thioacetamide (TAA), or carbon tetrachloride (CCl4 ). Hepatic and systemic iron overload were seen in the 0...
March 25, 2024: Toxicologic Pathology
https://read.qxmd.com/read/38527170/unraveling-the-genetic-link-an-umbrella-review-on-hla-b-15-02-and-antiepileptic-drug-induced-stevens-johnson-syndrome-toxic-epidermal-necrolysis
#9
JOURNAL ARTICLE
Kar Mun Tham, Jacklyn Jia Lin Yek, Christopher Wei Yang Liu
PURPOSE: This umbrella review was conducted to summarize the association between HLA*1502 allele with antiepileptic induced Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN). METHODS: Pubmed, Scopus and EMBASE were searched for eligible reviews in May 2023. Two authors independently screened titles and abstracts and assessed full-text reviews for eligibility. The quality of meta-analyses and case-control studies was appraised with Assessing the Methodological Quality of Systematic Reviews 2 and Newcastle-Ottawa Scale, respectively...
March 22, 2024: Pharmacogenetics and Genomics
https://read.qxmd.com/read/38526762/pharmacovigilance-of-nephrotoxic-drugs-in-neonates-the-pottel-method-for-acute-kidney-injury-detection-in-elbw-neonates
#10
JOURNAL ARTICLE
Mathilde Dumoulin, Hans Pottel, Djalila Mekahli, Annouschka Laenen, Anne Smits, Karel Allegaert
BACKGROUND: Extremely low birth weight (ELBW) neonates (birth weight ≤ 1000 g) are at high risk to develop drug-induced acute kidney injury (AKI). However, we lack a pragmatic detection tool to capture their time-dependent (patho)physiologic serum creatinine (Scr) patterns. Pottel et al. suggested rescaling Scr by dividing Scr with the mean Scr value of the age- and sex-specific reference population. We explored if this Pottel method can detect drug-related nephrotoxicity in ELBW neonates...
March 25, 2024: Pediatric Nephrology
https://read.qxmd.com/read/38526585/detection-of-drug-induced-interstitial-lung-disease-caused-by-cancer-treatment-using-electronic-nose-exhaled-breath-analysis
#11
JOURNAL ARTICLE
Iris G van der Sar, Marlies S Wijsenbeek, Daphne W Dumoulin, Agnes Jager, Astrid A M van der Veldt, Mariska J P Rossius, Anne-Marie C Dingemans, Catharina C Moor
No abstract text is available yet for this article.
March 25, 2024: Annals of the American Thoracic Society
https://read.qxmd.com/read/38523994/anaphylactic-reaction-to-patent-blue-dye-after-supermicrosurgical-lymphaticovenular-anastomosis-for-the-treatment-of-secondary-lymphedema
#12
Sina Heymans, Arie Sleutel, Thomas Schoeller, Laurenz Weitgasser
For decades, patent blue dye (PBV) has been utilized for sentinel lymph node biopsy and lymphatic mapping in breast cancer and melanoma staging and treatment. Fistulography and intraoperative display of lymphatic vessels for lymphaticovenular anastomosis (LVA) are frequent applications. Although its anaphylactic potential is well described, PBV is used routinely. We present the case of a 71-year-old female patient, who underwent LVA for the treatment of chronic secondary lymphedema and experienced a postoperative anaphylactic reaction including a blue-colored drug-induced maculopapular exanthema after PBV administration...
February 2024: Curēus
https://read.qxmd.com/read/38523545/dopaminergic-drugs-and-valproate-associated-refractory-hyponatremia-over-levosulpiride-induced-parkinsonism-in-an-elderly-female-patient-when-deprescribing-was-the-only-therapy
#13
JOURNAL ARTICLE
Amol Dehade, Sankha Shubhra Chakrabarti, Not Taruni Srija Reddy, Upinder Kaur
INTRODUCTION: Prescribing cascade is a condition in which a drug administered to a patient causes an adverse reaction that is misinterpreted as a new condition, resulting in the addition of a new drug. CASE PRESENTATION: Here, we report the case of an elderly female patient who suffered from metabolic, neurologic, and urinary consequences of a prescribing cascade of antiemetic, antiepileptic, and dopaminergic drugs. While levosulpiride caused Parkinsonian symptoms, the dopaminergic drugs and valproate caused refractory hyponatremia followed by altered sensorium, and clidinium contributed to urinary retention...
March 20, 2024: Current Drug Safety
https://read.qxmd.com/read/38522696/mechanisms-of-lipopolysaccharide-protection-in-tumor-drug-induced-macrophage-damage
#14
JOURNAL ARTICLE
Shuliang Song, Xiao Zhang, Lei Cui, Yan Wang, Xiao Tian, Ke Wang, Kai Ji
Malignant tumors contribute significantly to human mortality. Chemotherapy is a commonly used treatment for tumors. However, due to the low selectivity of chemotherapeutic drugs, immune cells can be damaged during antitumor treatment, resulting in toxicity. Lipopolysaccharide (LPS) can stimulate immune cells to respond to foreign substances. Here, we found that 10 ng/mL LPS could induce tolerance to antitumor drugs in macrophages without altering the effect of the drugs on tumor cells. Differentially expressed genes (DEGs) were identified between cells before and after LPS administration using transcriptome sequencing and found to be mainly associated with ATP-binding cassette (ABC)-resistant transporters and glutathione S-transferase (GST)...
March 22, 2024: International Journal of Biological Macromolecules
https://read.qxmd.com/read/38522313/multi-omics-reveals-that-5-o-methylvisammioside-prevention-acute-liver-injury-in-mice-by-regulating-the-tnf-mapk-nf-%C3%AE%C2%BAb-arachidonic-acid-pathway
#15
JOURNAL ARTICLE
Tingwen Zhang, Yue Zhong, Yan Shi, Chengcheng Feng, Lu Xu, Zheng Chen, Xin Sun, Yan Zhao, Xialin Sun
BACKGROUND: The pathogenesis of acute liver injury (ALI) has been a pressing issue in the medical scientific community. We previously found that 5-O-methylvisammioside (MeV) from Saposhnikovia divaricata (Turcz.) Schischk has excellent anti-inflammatory properties. However, the mechanism by which MeV protects against ALI still needs to be deeply investigated. PURPOSE: In the present study, we established an acetaminophen (APAP) -induced ALI mouse model and pre-protected the mice with MeV...
March 19, 2024: Phytomedicine
https://read.qxmd.com/read/38521841/aortitis-after-switching-short-acting-granulocyte-colony-stimulating-factors-in-a-lymphoma-patient-with-hla-b52
#16
JOURNAL ARTICLE
Misato Tane, Hideki Kosako, Hiroki Hosoi, Yoshiaki Furuya, Yoshikazu Hori, Yusuke Yamashita, Shogo Murata, Toshiki Mushino, Takashi Sonoki
Aortitis is a rare adverse event of granulocyte colony-stimulating factor (G-CSF) treatment. Several previous studies have described recurrent aortitis caused by re-administration of the same G-CSF. However, no previous studies have examined the safety of switching between short-acting G-CSFs in patients who develop aortitis. We report the case of a 55-year-old man with refractory diffuse large B-cell lymphoma, who developed G-CSF-associated aortitis. The aortitis was triggered by filgrastim and recurred after treatment with lenograstim...
March 23, 2024: International Journal of Hematology
https://read.qxmd.com/read/38521541/cytokeratin-18-is-a-sensitive-biomarker-of-alanine-transaminase-increase-in-a-placebo-controlled-randomized-crossover-trial-of-therapeutic-paracetamol-dosing-path-bp-biomarker-sub-study
#17
JOURNAL ARTICLE
Kathleen M Scullion, Iain M MacIntyre, Sian Sloan-Dennison, Benjamin Clark, Paul Fineran, Joanne Mair, David Creasey, Cicely Rathmell, Karen Faulds, Duncan Graham, David J Webb, James W Dear
Drug-induced liver injury (DILI) is a challenge in clinical medicine and drug development. Highly sensitive novel biomarkers have been identified for detecting DILI following a paracetamol overdose. The study objective was to evaluate biomarker performance in a 14-day trial of therapeutic dose paracetamol. The PATH-BP trial was a double-blind, placebo-controlled, crossover study. Individuals (n = 110) were randomized to receive 1 g paracetamol 4×daily or matched placebo for 2 weeks followed by a 2-week washout before crossing over to the alternate treatment...
March 23, 2024: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://read.qxmd.com/read/38521003/concurrent-inhibition-of-alk-and-src-kinases-disrupts-the-alk-lung-tumor-cell-proteome
#18
JOURNAL ARTICLE
Alberto Diaz-Jimenez, Maria Ramos, Barbara Helm, Sara Chocarro, Dario Lucas Frey, Shubham Agrawal, Kalman Somogyi, Ursula Klingmüller, Junyan Lu, Rocio Sotillo
Precision oncology has revolutionized the treatment of ALK-positive lung cancer with targeted therapies. However, an unmet clinical need still to address is the treatment of refractory tumors that contain drug-induced resistant mutations in the driver oncogene or exhibit resistance through the activation of diverse mechanisms. In this study, we established mouse tumor-derived cell models representing the two most prevalent EML4-ALK variants in human lung adenocarcinomas and characterized their proteomic profiles to gain insights into the underlying resistance mechanisms...
March 19, 2024: Drug Resistance Updates: Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy
https://read.qxmd.com/read/38519293/advanced-diagnostic-techniques-in-obstructive-sleep-apnea
#19
REVIEW
Seckin O Ulualp, Eric J Kezirian
Optimal surgical and medical management of obstructive sleep apnea (OSA) requires clinically reliable identification of patterns and sites of upper airway obstruction. A wide variety of modalities has been used to evaluate upper airway obstruction. Drug-induced sleep endoscopy (DISE) and cine MRI are increasingly used to identify upper airway obstruction sites, to characterize airway obstruction patterns, to determine optimum medical and surgical treatment, and to plan individualized surgical management. Here, the authors provide an overview of the applications of DISE and cine MRI in assessing upper airway obstruction in children and adults with OSA...
March 21, 2024: Otolaryngologic Clinics of North America
https://read.qxmd.com/read/38518604/senolytic-drugs-dasatinib-and-quercetin-combined-with-carboplatin-or-olaparib-reduced-the-peritoneal-and-adipose-tissue-metastasis-of-ovarian-cancer
#20
JOURNAL ARTICLE
Lian Wang, Bing Xiong, Wei Lu, Yujie Cheng, Jihui Zhu, Guihai Ai, Xiaojie Zhang, Xiuni Liu, Zhongping Cheng
Chemotherapy and targeted drugs-induced senescent ovarian cancer cells that accumulate in peritoneal adipose tissue contribute significantly to chronic inflammation, disrupt homeostasis, and may fuel various aspects of cancer progression. However, the pro-senescence effects of chemotherapy and targeted drugs on adipose derived stem cells (ADSCs) within peritoneal adipose tissue remain poorly understood. In this study, we show that the first-line chemotherapy and targeted drugs can induce the cellular senescence of ADSCs in vitro and increase the aging of peritoneal adipose tissue in vivo...
March 21, 2024: Biomedicine & Pharmacotherapy
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