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https://www.readbyqxmd.com/read/29208816/posterior-capsular-rent-prevention-and-management
#1
REVIEW
Arup Chakrabarti, Nazneen Nazm
This review article deals with a potentially sight threatening complication - rupture of the posterior capsule - during cataract surgery. Cataract surgery is the most commonly performed surgical procedure in ophthalmology and despite tremendous technical and technological advancements, posterior capsular rent (PCR) still occurs. PCR occurs both in the hands of experienced senior surgeons and the neophyte surgeons, although with a higher frequency in the latter group. Additionally, certain types of cataracts are prone to this development...
December 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29205056/ocular-bioanalysis-challenges-and-advancements-in-recent-years-for-these-rare-matrices
#2
Katja Heinig, Enric Bertran, Julian Potter, Daniela Fraier
There are many ocular diseases still presenting unmet medical needs. Therefore, new ophthalmologic drugs are being developed. Bioanalysis of eye compartments (along with plasma and other tissues) is important to determine exposure of the target organ to the drug and to help interpret local pharmacological or toxic effects. This review article identifies several challenges that occur within ocular bioanalysis. They include sample collection and preparation, analytical issues, sourcing control matrix, data interpretation and regulatory requirements...
December 5, 2017: Bioanalysis
https://www.readbyqxmd.com/read/29162153/managing-toxicities-associated-with-immune-checkpoint-inhibitors-consensus-recommendations-from-the-society-for-immunotherapy-of-cancer-sitc-toxicity-management-working-group
#3
I Puzanov, A Diab, K Abdallah, C O Bingham, C Brogdon, R Dadu, L Hamad, S Kim, M E Lacouture, N R LeBoeuf, D Lenihan, C Onofrei, V Shannon, R Sharma, A W Silk, D Skondra, M E Suarez-Almazor, Y Wang, K Wiley, H L Kaufman, M S Ernstoff
Cancer immunotherapy has transformed the treatment of cancer. However, increasing use of immune-based therapies, including the widely used class of agents known as immune checkpoint inhibitors, has exposed a discrete group of immune-related adverse events (irAEs). Many of these are driven by the same immunologic mechanisms responsible for the drugs' therapeutic effects, namely blockade of inhibitory mechanisms that suppress the immune system and protect body tissues from an unconstrained acute or chronic immune response...
November 21, 2017: Journal for Immunotherapy of Cancer
https://www.readbyqxmd.com/read/29137959/moving-from-clinic-to-home-what-the-future-holds-for-ophthalmic-telemedicine
#4
Nancy M Holekamp
PURPOSE: To describe the expanding role of telemedicine in healthcare, the key criteria required for a successful device and program implementation, and the current and future role of home monitoring in ophthalmology. DESIGN: Expert perspective METHODS: Analysis with real-world interpretation of home monitoring technologies including current adoption barriers and expanded future demands based on demographic and market forces. RESULTS: Remote patient monitoring represents a paradigm shift in the way physicians care for patients...
November 11, 2017: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/29096591/comparison-between-flipped-classroom-and-lecture-based-classroom-in-ophthalmology-clerkship
#5
Fen Tang, Chuan Chen, Yi Zhu, Chengguo Zuo, Yimin Zhong, Nan Wang, Lijun Zhou, Yuxian Zou, Dan Liang
BACKGROUND: In recent years, the flipped classroom method of teaching has received much attention in health sciences education. However, the application of flipped classrooms in ophthalmology education has not been well investigated. OBJECTIVE: The goal of this study was to investigate the effectiveness and acceptability of the flipped classroom approach to teaching ophthalmology at the clerkship level. DESIGN: Ninety-five fourth year medical students in an ophthalmology clerkship were randomly divided into two groups...
2017: Medical Education Online
https://www.readbyqxmd.com/read/29053133/-ophthalmic-disorders-as-a-manifestation-of-parkinson-s-disease
#6
N B Chesnokova, T A Pavlenko, M V Ugrumov
Parkinson's disease is a severe neurodegenerative disease accompanied with the degeneration of dopaminergic neurons in the central and peripheral nervous system. The diagnosis of Parkinson's disease can still be made only on the stage of irreversible and nearly total degeneration of the nigrostriatum dopaminergic system and exhaustion of brain compensatory mechanisms that explains the low efficacy of therapy. Ophthalmic pathology is one of the nonmotor symptoms of Parkinson's disease. This can be explained firstly by the fact that eye is a 'peripheral part of brain' and secondly by the involvement of dopaminergic neurons (dopamine-producing cells) that are subject to the selective degeneration during Parkinson's disease in the regulation of visual function in the eye and brain...
2017: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/29052094/severe-physical-complications-among-survivors-of-stevens-johnson-syndrome-and-toxic-epidermal-necrolysis
#7
Cristina Olteanu, Neil H Shear, Hall F Chew, Rena Hashimoto, Raed Alhusayen, Sonia Whyte-Croasdaile, Yaron Finkelstein, Marjorie Burnett, Michael Ziv, Shachar Sade, Marc G Jeschke, Roni P Dodiuk-Gad
INTRODUCTION: Few studies have reported the physical complications among Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) survivors. OBJECTIVE: The aim of this study was to comprehensively characterize the physical complications among SJS/TEN survivors and to learn about patients' perspectives of surviving SJS/TEN. METHODS: SJS/TEN survivors older than 18 years of age were assessed by different methods: a medical interview; a questionnaire assessing patients' perspectives; thorough skin, oral mucous membrane, and ophthalmic examinations; and a retrospective assessment of medical records...
October 19, 2017: Drug Safety: An International Journal of Medical Toxicology and Drug Experience
https://www.readbyqxmd.com/read/28992234/pharmacologic-management-of-diabetic-retinopathy
#8
Akiyoshi Uemura
Diabetic retinopathy (DR) is a leading cause of vision loss in working-age populations, primarily attributable to retinal vascular hyperpermeability, hypoperfusion, and neoangiogenesis. In the past decade, laser photocoagulation and surgical interventions to treat DR have been replaced by topical administrations of anti-vascular endothelial growth factor drugs and corticosteroids. Although these drugs have revolutionized clinical management of DR, their limited efficacy and adverse effects have raised an increasing demand for new drug development...
September 6, 2017: Journal of Biochemistry
https://www.readbyqxmd.com/read/28991343/endophthalmitis-following-pediatric-cataract-surgery-an-international-pediatric-ophthalmology-and-strabismus-council-global-perspective
#9
Almutez M Gharaibeh, Eedy Mezer, Luis H Ospina, Tamara Wygnanski-Jaffe
PURPOSE: To compile international data on the risk factors, diagnosis, and treatment of endophthalmitis following pediatric cataract surgery. METHODS: An e-mail containing a link to an online survey was sent to all members of the American Association for Pediatric Ophthalmology and Strabismus. The questionnaire examined the incidence, risk factors, treatment, outcomes, and prophylaxis of endophthalmitis following pediatric cataract surgery around the world. RESULTS: Two hundred thirty-seven ophthalmologists answered the questionnaire...
October 9, 2017: Journal of Pediatric Ophthalmology and Strabismus
https://www.readbyqxmd.com/read/28967080/new-pediatric-risk-factors-for-amblyopia-strabismic-versus-refractive
#10
Sandra Guimaraes, Maria Vieira, Tatiana Queirós, Andreia Soares, Patrício Costa, Eduardo Silva
PURPOSE: To assess the role of risk factors for amblyopia, such as family history and neonatal background, for the prediction of either strabismic amblyopia or refractive amblyopia. METHODS: In this retrospective case-control model, the study population included all children born at the Hospital de Braga during 1997-2012 (3 to 18 years old) with ophthalmologic consultation in 2014. Data collection was performed from the clinical database and through telephone questionnaire surveys...
September 11, 2017: European Journal of Ophthalmology
https://www.readbyqxmd.com/read/28958885/pathophysiology-screening-and-treatment-of-rop-a-multi-disciplinary-perspective
#11
REVIEW
Tailoi Chan-Ling, Glen A Gole, Graham E Quinn, Samuel J Adamson, Brian A Darlow
The population of infants at risk for retinopathy of prematurity (ROP) varies by world region; in countries with well developed neonatal intensive care services, the highest risk infants are those born at less than 28 weeks gestational age (GA) and less than 1 kg at birth, while, in regions where many aspects of neonatal intensive and ophthalmological care are not routinely available, more mature infants up to 2000 g at birth and 37 weeks GA are also at risk for severe ROP. Treatment options for both groups of patients include standard retinal laser photocoagulation or, more recently, intravitreal anti-VEGF drugs...
September 27, 2017: Progress in Retinal and Eye Research
https://www.readbyqxmd.com/read/28878742/zika-virus-what-have-we-learnt-since-the-start-of-the-recent-epidemic
#12
REVIEW
Juan-Carlos Saiz, Miguel A Martín-Acebes, Rubén Bueno-Marí, Oscar D Salomón, Luis C Villamil-Jiménez, Jorg Heukelbach, Carlos H Alencar, Paul K Armstrong, Tania M Ortiga-Carvalho, Rosalia Mendez-Otero, Paulo H Rosado-de-Castro, Pedro M Pimentel-Coelho
Zika is a viral disease transmitted mainly by mosquitoes of the genus Aedes. In recent years, it has expanded geographically, changing from an endemic mosquito-borne disease across equatorial Asia and Africa, to an epidemic disease causing large outbreaks in several areas of the world. With the recent Zika virus (ZIKV) outbreaks in the Americas, the disease has become a focus of attention of public health agencies and of the international research community, especially due to an association with neurological disorders in adults and to the severe neurological and ophthalmological abnormalities found in fetuses and newborns of mothers exposed to ZIKV during pregnancy...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28870710/communication-skills-training-in-ophthalmology-results-of-a-needs-assessment-and-pilot-training-program
#13
Anuradha Mishra, David Browning, Miriam J Haviland, Mary Lou Jackson, Donna Luff, Elaine C Meyer, Katherine Talcott, Carolyn E Kloek
OBJECTIVE: To conduct a needs assessment to identify gaps in communication skills training in ophthalmology residency programs and to use these results to pilot a communication workshop that prepares residents for difficult conversations. DESIGN: A mixed-methods design was used to perform the needs assessment. A pre-and postsurvey was administered to workshop participants. SETTING: Mass Eye and Ear Infirmary, Harvard Medical School (HMS), Department of Ophthalmology...
September 1, 2017: Journal of Surgical Education
https://www.readbyqxmd.com/read/28774510/perspective-on-a-formal-mentorship-program-in-ophthalmology-residency
#14
EDITORIAL
Georges Nassrallah, Sourabh Arora, Sadhana Kulkarni, Cindy M L Hutnik
No abstract text is available yet for this article.
August 2017: Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie
https://www.readbyqxmd.com/read/28670228/treatment-and-outcomes-medical-and-surgical-treatment-for-intestinal-beh%C3%A3-et-s-disease
#15
REVIEW
Tadakazu Hisamatsu, Mari Hayashida
Behçet's disease (BD) is a chronic relapsing disease involving multiple organ systems. BD is characterized clinically by oral and genital aphthae, cutaneous lesions, and ophthalmological, neurological, and/or gastrointestinal manifestations. It is widely recognized that the presence of intestinal lesions may be a poor prognostic factor in intestinal BD, increasing the risk of surgery and decreasing the quality of life. Despite this, the management of intestinal BD has not been standardized. Empirical therapies including 5-aminosalicylic acid and corticosteroids have been used anecdotally to treat intestinal BD, but recent studies have provided evidence for the efficacy of anti-tumor necrosis factor α monoclonal antibodies...
July 2017: Intestinal Research
https://www.readbyqxmd.com/read/28653208/-employed-and-self-employed-specialists-in-outpatient-ophthalmological-care-comparison-with-other-specialist-fields
#16
U Hahn, F Kretz, B Awe, J Koch
AIM: The aim of the study was to evaluate the contribution to outpatient care and the perspectives of employed and self-employed ophthalmologists in isolation and in comparison to other professional groups. METHOD: Based on statistical data (source: statistical information provided by the National Association of Statutory Health Insurance Physicians) from 31 December 2015, newly admitted physicians in 2015 and their contribution differentiated by employment relationships were evaluated according to head count and working time equivalents (using "planning of demand equivalents")...
June 26, 2017: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
https://www.readbyqxmd.com/read/28643176/a-promising-tool-in-retina-regeneration-current-perspectives-and-challenges-when-using-mesenchymal-progenitor-stem-cells-in-veterinary-and-human-ophthalmological-applications
#17
REVIEW
Anna Cislo-Pakuluk, Krzysztof Marycz
Visual impairment is a common ailment of the current world population, with more exposure to CCD screens and fluorescent lighting, approximately 285 billion people suffer from this deficiency and 13% of those are considered clinically blind. More common causes for visual impairment include age-related macular degeneration (AMD), glaucoma and diabetic retinopathy (Zhu et al. Molecular Medicine Reports, 2015; Kolb et al. 2007; Machalińska et al. Current Eye Research, 34(9),748-760, 2009) among a few. As cases of retinal and optic nerve diseases rise, it is vital to find a treatment, which has led to investigation of the therapeutic potential of various stem cells types (Bull et al...
October 2017: Stem Cell Reviews
https://www.readbyqxmd.com/read/28586930/-mid-and-longterm-experiences-with-the-boston-keratoprosthesis-the-cologne-and-salzburg-perspective
#18
Friederike Schaub, Björn O Bachmann, Orang Seyeddain, Sarah Moussa, Herbert A Reitsamer, Claus Cursiefen
Background Eyes with severe corneal opacifications and insufficient prognosis for high-risk corneal transplantation can be considered for the implantation of a Boston-keratoprosthesis. Since 2013, this technique of "artificial" corneal replacement is provided to high-risk eyes at the Department of Ophthalmology, University of Cologne and for 9 years at the University of Salzburg. In the meantime, a type I Boston keratoprosthesis (BI-KPro) has been implanted in 24 eyes in Cologne and in 28 eyes in Salzburg. Methods In this article, results and complications according to BI-KPro are discussed, both from the literature in PubMed, as well as from our own experiences...
June 2017: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/28554534/ophthalmic-manifestations-of-xeroderma-pigmentosum-a-perspective-from-the-united-kingdom
#19
Rongxuan Lim, Mieran Sethi, Ana M S Morley
PURPOSE: To document the ocular manifestations of xeroderma pigmentosum (XP), presenting via the United Kingdom (UK) XP service, and to analyze the correlations between XP genotype and ophthalmic phenotype. DESIGN: Prospective observational case series. SUBJECTS: Eighty-nine patients seen by the UK Nationally Commissioned XP Service, from April 2010 to December 2014, with a genetically confirmed diagnosis of XP. METHODS: Patients underwent a full ophthalmic examination at each visit...
November 2017: Ophthalmology
https://www.readbyqxmd.com/read/28498929/multi-stakeholder-perspectives-in-defining-health-services-quality-in-cataract-care
#20
Aline C Stolk-Vos, Joris J van de Klundert, Niels Maijers, Bart L M Zijlmans, Jan J V Busschbach
Objective: To develop a method to define a multi-stakeholder perspective on health-service quality that enables the expression of differences in systematically identified stakeholders' perspectives, and to pilot the approach for cataract care. Design: Mixed-method study between 2014 and 2015. Setting: Cataract care in the Netherlands. Participants: Stakeholder representatives. Intervention(s): We first identified and classified stakeholders using stakeholder theory...
August 1, 2017: International Journal for Quality in Health Care
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