Canying Liu, Jiahui Tang, Yuze Chen, Qi Zhang, Jicheng Lin, Siting Wu, Jiaxu Han, Zhe Liu, Caiqing Wu, Yehong Zhuo, Yiqing Li
Given the widespread application of glucocorticoids in ophthalmology, the associated elevation of intraocular pressure (IOP) has long been a vexing concern for clinicians, yet the underlying mechanisms remain inconclusive. Much of the discussion focuses on the extracellular matrix (ECM) of trabecular meshwork (TM). It's widely agreed that glucocorticoids impact the expression of Matrix metalloproteinases (MMPs), leading to ECM deposition. Since Zn2+ is vital for MMPs, we explored its role in ECM alterations induced by dexamethasone (DEX)...
March 25, 2024: American Journal of Physiology. Cell Physiology