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https://www.readbyqxmd.com/read/28643176/a-promising-tool-in-retina-regeneration-current-perspectives-and-challenges-when-using-mesenchymal-progenitor-stem-cells-in-veterinary-and-human-ophthalmological-applications
#1
REVIEW
Anna Cislo-Pakuluk, Krzysztof Marycz
Visual impairment is a common ailment of the current world population, with more exposure to CCD screens and fluorescent lighting, approximately 285 billion people suffer from this deficiency and 13% of those are considered clinically blind. More common causes for visual impairment include age-related macular degeneration (AMD), glaucoma and diabetic retinopathy (Zhu et al. Molecular Medicine Reports, 2015; Kolb et al. 2007; Machalińska et al. Current Eye Research, 34(9),748-760, 2009) among a few. As cases of retinal and optic nerve diseases rise, it is vital to find a treatment, which has led to investigation of the therapeutic potential of various stem cells types (Bull et al...
June 22, 2017: Stem Cell Reviews
https://www.readbyqxmd.com/read/28586930/-mid-and-longterm-experiences-with-the-boston-keratoprosthesis-the-cologne-and-salzburg-perspective
#2
Friederike Schaub, Björn O Bachmann, Orang Seyeddain, Sarah Moussa, Herbert A Reitsamer, Claus Cursiefen
Background Eyes with severe corneal opacifications and insufficient prognosis for high-risk corneal transplantation can be considered for the implantation of a Boston-keratoprosthesis. Since 2013, this technique of "artificial" corneal replacement is provided to high-risk eyes at the Department of Ophthalmology, University of Cologne and for 9 years at the University of Salzburg. In the meantime, a type I Boston keratoprosthesis (BI-KPro) has been implanted in 24 eyes in Cologne and in 28 eyes in Salzburg. Methods In this article, results and complications according to BI-KPro are discussed, both from the literature in PubMed, as well as from our own experiences...
June 2017: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/28554534/ophthalmic-manifestations-of-xeroderma-pigmentosum-a-perspective-from-the-united-kingdom
#3
Rongxuan Lim, Mieran Sethi, Ana M S Morley
PURPOSE: To document the ocular manifestations of xeroderma pigmentosum (XP), presenting via the United Kingdom (UK) XP service, and to analyze the correlations between XP genotype and ophthalmic phenotype. DESIGN: Prospective observational case series. SUBJECTS: Eighty-nine patients seen by the UK Nationally Commissioned XP Service, from April 2010 to December 2014, with a genetically confirmed diagnosis of XP. METHODS: Patients underwent a full ophthalmic examination at each visit...
May 26, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28498929/multi-stakeholder-perspectives-in-defining-health-services-quality-in-cataract-care
#4
Aline C Stolk-Vos, Joris J van de Klundert, Niels Maijers, Bart L M Zijlmans, Jan J V Busschbach
Objective: To develop a method to define a multi-stakeholder perspective on health-service quality that enables the expression of differences in systematically identified stakeholders' perspectives, and to pilot the approach for cataract care. Design: Mixed-method study between 2014 and 2015. Setting: Cataract care in the Netherlands. Participants: Stakeholder representatives. Intervention(s): We first identified and classified stakeholders using stakeholder theory...
May 11, 2017: International Journal for Quality in Health Care
https://www.readbyqxmd.com/read/28476437/sjogren-s-syndrome-from-the-perspective-of-ophthalmology
#5
Eric Kuklinski, Penny A Asbell
Sjogren's syndrome (SS) is an autoimmune disease affecting the lacrimal glands resulting in dry eye disease (DED). Ophthalmologists may be the first line of detection of Sjogren's syndrome given the frequency of DED in SS and that dry eye is often the presenting symptom. Numerous symptom questionnaires and tests have been developed to help diagnose DED, but as of yet, there is no "gold standard." Minimally invasive objective metrics are needed for a reliable diagnosis of DED. Currently there is no single test to diagnose SS-associated DED...
May 2, 2017: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://www.readbyqxmd.com/read/28455280/-the-patient-is-speaking-discovering-the-patient-voice-in-ophthalmology
#6
REVIEW
Samera Dean, Jonathan M Mathers, Melanie Calvert, Derek G Kyte, Dolores Conroy, Annie Folkard, Sue Southworth, Philip I Murray, Alastair K Denniston
Eye disease can be devastating. The most feared impact is sight loss, but in a number of ophthalmic conditions, there can be wide-ranging systemic, psychological, emotional and social effects of both the disease and its treatment. External tests of visual function, such as visual acuity, are inadequate to understand the overall impact of ophthalmic disease on a patient's functional vision or daily life. This can lead to a discordance between the patient's priorities and perspective on the one hand and the efforts of clinicians and other stakeholders on the other hand...
June 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28440246/what-s-new-for-us-in-strabismus
#7
Pradeep Sharma, Nripen Gaur, Swati Phuljhele, Rohit Saxena
Strabismus is one of the most challenging subspecialties encountered in the field of ophthalmology. The concept of etiology of strabismus is being advanced with the development of newer imaging modalities and increased understanding of the genetics of strabismus. Imaging is also being used to aid in the planning of strabismus surgery. Newer horizons are being explored in the amblyopia management. The good old eye-pad is being replaced with the iPad. Early detection of loss of stereopsis is being used to decide the timing for strabismus surgery...
March 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/28439655/-ocular-graft-versus-host-disease-corneal-complications
#8
H Westekemper, S L Scholz, H Thomasen, C Halfwassen, K-P Steuhl
BACKGROUND: Ocular graft-versus-host disease (GvHD) following allogeneic blood stem cell transplantation leads to immunologically induced alterations in many ocular tissues, particularly at the ocular surface. Within the framework of the main topic, this article focuses primarily on corneal complications in chronic ocular GvHD. OBJECTIVE: This article aims to promote understanding of the influencing factors, diagnostics, and therapeutic options pertaining to corneal complications in ocular GvHD...
April 24, 2017: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
https://www.readbyqxmd.com/read/28414044/the-impact-of-the-medicare-access-and-chip-reauthorization-act-macra-on-the-field-of-ophthalmology
#9
Brenton Kinker, Kaitlyn Dobesh, Nariman Nassiri, Mark S Juzych, M Roy Wilson
PURPOSE: To analyze the impact of the Medicare Access and CHIP Reauthorization Act of 2015 (MACRA) on the field of ophthalmology. DESIGN: A perspective on the effects of MACRA's Quality Payment Program after analysis of the proposed rule, final rule, and commentary submitted by relevant stakeholders. RESULTS: Physicians will need to use one of two payment structures: Merit Based Incentive Payment Systems (MIPS), or Alternative Payment Models (APMs)...
April 13, 2017: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/28271003/optical-coherence-tomography-based-angiography-invited
#10
REVIEW
Chieh-Li Chen, Ruikang K Wang
Optical coherence tomography (OCT)-based angiography (OCTA) provides in vivo, three-dimensional vascular information by the use of flowing red blood cells as intrinsic contrast agents, enabling the visualization of functional vessel networks within microcirculatory tissue beds non-invasively, without a need of dye injection. Because of these attributes, OCTA has been rapidly translated to clinical ophthalmology within a short period of time in the development. Various OCTA algorithms have been developed to detect the functional micro-vasculatures in vivo by utilizing different components of OCT signals, including phase-signal-based OCTA, intensity-signal-based OCTA and complex-signal-based OCTA...
February 1, 2017: Biomedical Optics Express
https://www.readbyqxmd.com/read/28191476/pharmacological-treatments-of-presbyopia-a-review-of-modern-perspectives
#11
REVIEW
Antonio Renna, Jorge Luciano Alió, Luis Felipe Vejarano
INTRODUCTION: Presbyopia affects people from the 4(th) decade of life and is characterized by accommodative loss that leads to negative effects on vision-targeted health-related quality of life. A non-invasive pharmacological treatment providing near-lenses independence would be a truly groundbreaking approach in the treatment of presbyopia. The purpose of this review is to analyze the emerging pharmacological solutions proposed to address presbyopia. RESULTS: Several ophthalmic eye drops compounds solutions have been described in peer-reviewed papers or presented in ophthalmological tabloids and congresses...
2017: Eye and Vision (London, England)
https://www.readbyqxmd.com/read/28161930/electronic-referrals-and-digital-imaging-systems-in-ophthalmology-a-global-perspective
#12
V Swetha E Jeganathan, H Nikki Hall, Roshini Sanders
Ophthalmology departments face intensifying pressure to expedite sight-saving treatments and reduce the global burden of disease. The use of electronic communication systems, digital imaging, and redesigned service care models is imperative for addressing such demands. The recently developed Scottish Eyecare Integration Project involves an electronic referral system from community optometry to the hospital ophthalmology department using National Health Service (NHS) email with digital ophthalmic images attached, via a virtual private network connection...
January 2017: Asia-Pacific Journal of Ophthalmology
https://www.readbyqxmd.com/read/28138753/-evaluation-of-methodological-quality-in-published-rcts-on-cataract-surgery-pilot-study-on-the-degree-of-adherence-to-consort-statement-requirements-and-their-qualitative-validity
#13
C Baulig, F Krummenauer, S Knippschild
BACKGROUND: The CONSORT statement can be considered as a guideline to ensure transparency in the reporting of randomized clinical trials (RCT), in addition to specific author instructions and requirements of journals. It provides a total of 25 criteria and 12 additional subcriteria on methodological and regulatorical determinants of clinical trials. The availability of the CONSORT recommendations, however, does not necessarily imply adherence to their obligations and correct realisation of the latter from a methodological perspective, so that even in ophthalmology a lack of transparency in trial reporting cannot be excluded...
January 30, 2017: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
https://www.readbyqxmd.com/read/28004586/psycho-ophthalmology-contributions-of-health-psychology-to-the-assessment-and-treatment-of-glaucoma
#14
REVIEW
Jorge Luis Méndez-Ulrich, Antoni Sanz
BACKGROUND: Asymptomatic in its early stages, glaucoma is the second leading cause of blindness worldwide. While psychosocial factors are taken into consideration for a host of diseases such as cancer, heart disease and autoimmune conditions, to date, psychological issues have been ignored in the clinical management of glaucoma. OBJECTIVE: This work reviews the most relevant contributions from a health psychology perspective for the assessment and treatment of glaucoma, which is emerging in the field of psycho-ophthalmology...
March 2017: Psychology & Health
https://www.readbyqxmd.com/read/27787744/simulation-modelling-in-ophthalmology-application-to-cost-effectiveness-of-ranibizumab-and-aflibercept-for-the-treatment-of-wet-age-related-macular-degeneration-in-the-united-kingdom
#15
Lindsay Claxton, Robert Hodgson, Matthew Taylor, Bill Malcolm, Ruth Pulikottil Jacob
BACKGROUND: Previously developed models in ophthalmology have generally used a Markovian structure. There are a number of limitations with this approach, most notably the ability to base patient outcomes on best-corrected visual acuity (BCVA) in both eyes, which may be overcome using a different modelling structure. Simulation modelling allows for this to be modelled more precisely, and therefore may provide more accurate and relevant estimates of the cost effectiveness of ophthalmology interventions...
February 2017: PharmacoEconomics
https://www.readbyqxmd.com/read/27769318/perspectives-on-canadian-postgraduate-education-in-ophthalmology
#16
EDITORIAL
Ian M MacDonald, Bernard Hurley, Chris Seamone
No abstract text is available yet for this article.
October 2016: Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie
https://www.readbyqxmd.com/read/27703662/in-vivo-evaluation-of-the-biomechanical-properties-of-optic-nerve-and-peripapillary-structures-by-ultrasonic-shear-wave-elastography-in-glaucoma
#17
Atilla Suleyman Dikici, Ismail Mihmanli, Fahrettin Kilic, Ahmet Ozkok, Gokhan Kuyumcu, Pinar Sultan, Cesur Samanci, Mehmet Halit Yilmaz, Babak Rafiee, Nevbahar Tamcelik, Zehra Isik Hasiloglu, Fatih Kantarci
BACKGROUND: Primary open-angle glaucoma is a multifactorial serious disease characterized by progressive retinal ganglion cell death and loss of visual field. OBJECTIVES: The purposes of this study were to investigate shear wave elastography (SWE) use in the evaluation of the optic nerve (ON) and peripapillary structures, and to compare the findings between glaucomatous and control eyes. PATIENTS AND METHODS: A case-controlled study, including 21 patients with primary open-angle glaucoma and 21 age-matched control subjects, was carried out...
April 2016: Iranian Journal of Radiology: a Quarterly Journal Published By the Iranian Radiological Society
https://www.readbyqxmd.com/read/27679736/novel-insights-into-the-polycythemia-paraganglioma-somatostatinoma-syndrome
#18
Roland Därr, Joan Nambuba, Jaydira Del Rivero, Ingo Janssen, Maria Merino, Milena Todorovic, Bela Balint, Ivana Jochmanova, Josef T Prchal, Ronald M Lechan, Arthur S Tischler, Vera Popovic, Dragana Miljic, Karen T Adams, F Ryan Prall, Alexander Ling, Meredith R Golomb, Michael Ferguson, Naris Nilubol, Clara C Chen, Emily Chew, David Taïeb, Constantine A Stratakis, Tito Fojo, Chunzhang Yang, Electron Kebebew, Zhengping Zhuang, Karel Pacak
Worldwide, the syndromes of paraganglioma (PGL), somatostatinoma (SOM) and early childhood polycythemia are described in only a few patients with somatic mutations in the hypoxia-inducible factor 2 alpha (HIF2A). This study provides detailed information about the clinical aspects and course of 7 patients with this syndrome and brings into perspective these experiences with the pertinent literature. Six females and one male presented at a median age of 28 years (range 11-46). Two were found to have HIF2A somatic mosaicism...
December 2016: Endocrine-related Cancer
https://www.readbyqxmd.com/read/27664288/historical-perspectives-on-the-management-of-macular-degeneration-diabetic-retinopathy-and-retinal-detachment-personal-reminiscences
#19
Stuart L Fine, Morton F Goldberg, William Tasman
We were challenged and delighted when Dr. Sharon Solomon, guest editor of this Retina Supplement, invited us to reminisce about caring for patients with common retinal disorders before there was access to the diagnostic and therapeutic tools that are readily available today. We agreed to confine our remarks to 3 common, but serious, conditions: age-related macular degeneration (Dr. Fine), diabetic retinopathy (Dr. Goldberg), and retinal detachment (Dr. Tasman). Each of us completed our ophthalmology training about half a century ago...
October 2016: Ophthalmology
https://www.readbyqxmd.com/read/27579460/perspective-of-ophthalmology-residents-in-the-united-states-about-residency-programs-and-competency-in-relation-to-the-international-council-of-ophthalmology-guidelines
#20
Nizar Saleh Abdelfattah, Ahmed E Radwan, Srinivas R Sadda
PURPOSE: To evaluate the perspective of ophthalmology residents in the US about their residency programs and compare the competency of residency programs to international competency levels set by the International Council of Ophthalmology (ICO). METHODS: A cross-sectional web-based survey extracted from the ICO published competency standards was sent to program directors of ophthalmology residency programs in the US to forward it to current PGY-3, 4 residents, and residency graduates from 2011 to 2014...
September 2016: Journal of Current Ophthalmology
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