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controlled drug screening tests

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https://www.readbyqxmd.com/read/28918577/microarray-based-snp-genotyping-to-identify-genetic-risk-factors-of-triple-negative-breast-cancer-tnbc-in-south-indian-population
#1
M Aravind Kumar, Vineeta Singh, Shaik Mohammad Naushad, Uday Shanker, M Lakshmi Narasu
In the view of aggressive nature of Triple-Negative Breast cancer (TNBC) due to the lack of receptors (ER, PR, HER2) and high incidence of drug resistance associated with it, a case-control association study was conducted to identify the contributing genetic risk factors for Triple-negative breast cancer (TNBC). A total of 30 TNBC patients and 50 age and gender-matched controls of Indian origin were screened for 9,00,000 SNP markers using microarray-based SNP genotyping approach. The initial PLINK association analysis (p < 0...
September 16, 2017: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/28916103/controlled-synchronized-actuation-of-microdroplets-by-gravity-in-a-superhydrophobic-3d-printed-device
#2
P E Oomen, J P S H Mulder, E Verpoorte, R D Oleschuk
Droplet manipulation over open surfaces allows one to perform assays with a large degree of control and high throughput, making them appealing for applications in drug screening or (bio)analysis. However, the design, manufacturing and operation of these systems comes with high technical requirements. In this study we employ a commercial, low-friction, superhydrophobic coating, Ultra-Ever Dry(®), on a 3D-printed microfluidic device. The device features individual droplet compartments, which allow the manipulation of discrete droplets (10-50 μL) actuated by gravity alone...
October 2, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/28913613/risk-factor-analysis-between-newly-screened-and-established-hepatitis-c-in-gi-and-hepatology-clinics
#3
Newaz Hossain, Bharat Puchakayala, Pushpjeet Kanwar, Siddharth Verma, George Abraham, Zhanna Ivanov, Muhammad Obaid Niaz, Smruti R Mohanty
BACKGROUND: Several studies show inconsistencies in the rate of hepatitis C virus (HCV) detection among baby boomers (born 1945-1965). We conducted a cross-sectional HCV screening followed by a case-controlled comparison of the newly screened population with established HCV subjects. METHOD: Enrollment was offered to subjects aged 40-75 at our gastroenterology and hepatology clinics. Demographic data and potential risk factors were obtained, and HCV antibody test was offered to those who had never been screened and compared with a group with established HCV...
September 14, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28899692/in-vitro-efficacy-of-bumped-kinase-inhibitors-against-besnoitia-besnoiti-tachyzoites
#4
Alejandro Jiménez-Meléndez, Kayode K Ojo, Alexandra M Wallace, Tess R Smith, Andrew Hemphill, Vreni Balmer, Javier Regidor-Cerrillo, Luis M Ortega-Mora, Adrian B Hehl, Erkang Fan, Dustin J Maly, Wesley C Van Voorhis, Gema Álvarez-García
Besnoitia besnoiti is an apicomplexan parasite responsible for bovine besnoitiosis, a chronic and debilitating disease that causes systemic and skin manifestations and sterility in bulls. Neither treatments nor vaccines are currently available. In the search for therapeutic candidates, calcium-dependent protein kinases (CDPKs) have arisen as promising drug targets in other apicomplexans (e.g. Neospora caninum, Toxoplasma gondii, Plasmodium spp. and Eimeria spp.) and are effectively targeted by bumped kinase inhibitors (BKIs)...
September 9, 2017: International Journal for Parasitology
https://www.readbyqxmd.com/read/28894573/prevalence-of-hepatitis-c-in-people-who-inject-drugs-in-the-cities-of-rawalpindi-and-islamabad-pakistan
#5
Yasir Waheed, Muzammil Hasan Najmi, Hafsa Aziz, Hasnain Waheed, Muhammad Imran, Sher Zaman Safi
Pakistan has the second highest burden of hepatitis C (HCV) in the world. The major route of HCV transmission is contaminated blood or needle sharing. Seventy percent of people who inject drugs (PWIDs) shared needles at some time in their addiction history. The aim of the present study was to estimate the prevalence of HCV in PWIDs in cities of Pakistan. We enrolled 100 PWIDs from the Rawalpindi and Islamabad cities of Pakistan. Blood samples were taken in collection tubes and were subjected to HCV screening by using three rapid HCV screening kits including one step anti-HCV test, onsite HCV Ab rapid test and advance quality rapid anti-HCV test...
September 2017: Biomedical Reports
https://www.readbyqxmd.com/read/28893570/phytoestrogenic-effect-of-inula-racemosa-hook-f-a-cardioprotective-root-drug-in-traditional-medicine
#6
Kalachaveedu Mangathayaru, Divya Raghavan, Srivani Telapolu, Sarah Kuruvilla, Kedike Balakrishna
ETHNOPHARMACOLOGICAL RELEVANCE: Roots of Inula racemosa are used as a cardio protective in Ayurveda in India, being prescribed as a medicine for precordial chest pain, cough and dyspnoea, both singly and as a poly herbal. AIM: Evaluation of Phytoestrogenic activity of the root extracts of Inula racemosa and compounds isolated therefrom in vivo, in silico and in vitro. MATERIALS AND METHODS: Alcohol (IrA) and hexane (IrH) extracts characterized by HPTLC/GC-MS analysis respectively and processed for compound isolation were evaluated for estrogenic activity (100 &250mg/kg bw) by the Immature rat uterotrophic assay using ethinylestradiol (EE -30µg/kg bw) as standard drug...
September 8, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28893216/antimalarial-efficacy-of-pongamia-pinnata-l-pierre-against-plasmodium-falciparum-3d7-strain-and-plasmodium-berghei-anka
#7
P V V Satish, K Sunita
BACKGROUND: The objective of the current study was to assess the in vitro antiplasmodial activities of leaf, bark, flower, and the root of Pongamia pinnata against chloroquine-sensitive Plasmodium falciparum (3D7 strain), cytotoxicity against Brine shrimp larvae and THP-1 cell line. For in vivo study, the plant extract which has shown potent in vitro antimalarial activity was tested against Plasmodium berghei (ANKA strain). METHODS: The plant Pongamia pinnata was collected from the herbal garden of Acharya Nagarjuna University of Guntur district, Andhra Pradesh, India...
September 11, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28891445/patient-variables-associated-with-the-assignment-of-a-formal-dementia-diagnosis-to-positively-screened-primary-care-patients
#8
Tilly Eichler, Jochen René Thyrian, Johannes Hertel, Steffen Richter, Bernhard Michalowsky, Diana Wucherer, Adina Dreier, Ingo Kilimann, Stefan Teipel, Wolfgang Hoffmann
BACKGROUND: Main objective was to analyze the associations of patient variables (depression, quality of life, anti-dementia drug treatment, knowledge about dementia) with the assignment of a formal diagnosis of dementia to community-dwelling primary care patients who have screened positive for dementia. METHODS: DelpHi-MV (Dementia: life- and person-centered help in Mecklenburg-Western Pomerania) is a general practitioner based randomized controlled intervention trial...
September 7, 2017: Current Alzheimer Research
https://www.readbyqxmd.com/read/28891235/financial-arrangements-for-health-systems-in-low-income-countries-an-overview-of-systematic-reviews
#9
REVIEW
Charles S Wiysonge, Elizabeth Paulsen, Simon Lewin, Agustín Ciapponi, Cristian A Herrera, Newton Opiyo, Tomas Pantoja, Gabriel Rada, Andrew D Oxman
BACKGROUND: One target of the Sustainable Development Goals is to achieve "universal health coverage, including financial risk protection, access to quality essential health-care services and access to safe, effective, quality and affordable essential medicines and vaccines for all". A fundamental concern of governments in striving for this goal is how to finance such a health system. This concern is very relevant for low-income countries. OBJECTIVES: To provide an overview of the evidence from up-to-date systematic reviews about the effects of financial arrangements for health systems in low-income countries...
September 11, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28889312/discovering-selective-diguanylate-cyclase-inhibitors-from-pled-to-discrimination-of-the-active-site-of-cyclic-di-gmp-phosphodiesterases
#10
S Rinaldo, G Giardina, F Mantoni, A Paiardini, Alessio Paone, Francesca Cutruzzolà
One of the most important signals involved in controlling biofilm formation is represented by the intracellular second messenger 3',5'-cyclic diguanylic acid (c-di-GMP). Since the pathways involved in c-di-GMP biosynthesis and breakdown are found only in bacteria, targeting c-di-GMP metabolism represents an attractive strategy for the development of biofilm-disrupting drugs. Here, we present the workflow required to perform a structure-based design of inhibitors of diguanylate cyclases, the enzymes responsible for c-di-GMP biosynthesis...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28886591/predictors-of-early-dropout-in-treatment-for-gambling-disorder-the-role-of-personality-disorders-and-clinical-syndromes
#11
G Maniaci, C La Cascia, F Picone, A Lipari, C Cannizzaro, D La Barbera
Several treatment options for gambling disorder (GD) have been tested in recent years; however dropout levels still remain high. This study aims to evaluate whether the presence of psychiatric comorbidities predicts treatment outcome according to Millon's evolutionary theory, following a six-month therapy for GD. The role of severity, duration of the disorder, typology of gambling (mainly online or offline) and pharmacological treatment were also analysed. The recruitment included 194 pathological gamblers (PGs) to be compared with 78 healthy controls (HCs)...
August 5, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28885219/recognition-of-possible-risk-factors-for-clinically-significant-drug-drug-interactions-among-indian-people-living-with-hiv-receiving-highly-active-antiretroviral-therapy-and-concomitant-medications
#12
Poka Siva Sai Lakshmi Priyanka, Danturulu Muralidhar Varma, Kavyasri Immadisetti, Radhakrishnan Rajesh, Sudha Vidyasagar, Vasudeva Guddattu
BACKGROUND: Greatest challenges for clinician is to recognize risk factors for clinically significant drug interactions (CSDIs). There is a lack of awareness about CSDIs among healthcare professionals in India. OBJECTIVE: To recognize all possible risk factors for drug-drug interactions (DDIs) and to identify clinically significant drug interactions (CSDIs), the prevalence, pattern of occurrence of DDIs in People Living with HIV (PLW-HIV) receiving highly active antiretroviral therapy (HAART) and concomitant medications...
2017: International Journal of Risk & Safety in Medicine
https://www.readbyqxmd.com/read/28879439/mannose-binding-lectin-mbl-deficiency-and-tuberculosis-infection-in-patients-with-ankylosing-spondylitis
#13
Renato Nisihara, Thelma Skare, Vinícius Maestri, Juliana S Alegretti, Ana Paula B Campos, Iara Messias-Reason
Ankylosing spondylitis (AS) patients may have higher prevalence of mannose-binding lectin (MBL) deficiency than normal individuals. MBL deficiency may influence susceptibility to infections. The aim of the study was to verify if MBL deficiency in patients with AS predisposes to infections. We studied 60 patients with AS diagnosed according to the Assessment of SpondyloArthritis international Society (ASAS) criteria. These patients had their MBL serum levels determinated. Twenty-five individuals were identified as MBL deficient (serum values 100 ng/mL)...
September 6, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28879163/diagnostic-system-strengthening-for-drug-resistant-tuberculosis-in-nigeria-impact-and-challenges
#14
Gambo Aliyu, Nicholas Ezati, Mosunmola Iwakun, Sam Peters, Alash'le Abimiku
BACKGROUND: The increasing prevalence of drug-resistant tuberculosis and the threat of extensively-drug-resistant tuberculosis in HIV hotspots have made the detection and treatment of drug-resistant tuberculosis in the sub-Saharan Africa setting a global public health priority. OBJECTIVE: We sought to examine the impact and challenges of tuberculosis diagnostic capacity development for the detection of drug-resistant tuberculosis and bio-surveillance using a modular biosafety level 3 (BSL-3) laboratory in Nigeria...
2017: African Journal of Laboratory Medicine
https://www.readbyqxmd.com/read/28879021/diamond-digital-alcohol-management-on-demand-a-mixed-methods-feasibility-rct-and-embedded-process-evaluation-of-a-digital-health-intervention-to-reduce-hazardous-and-harmful-alcohol-use
#15
Fiona L Hamilton, Jo Hornby, Jessica Sheringham, Stuart Linke, Charlotte Ashton, Kevin Moore, Fiona Stevenson, Elizabeth Murray
BACKGROUND: Alcohol is a major risk factor for preventable illness, with huge cost to healthcare economies. There is a role for alcohol-specific digital health interventions (DHI), but there have been few randomised controlled trials (RCT) comparing DHI with face-to-face treatment. Such trials are complex and face obstacles in recruitment and retention. METHODS: Mixed-methods feasibility RCT of an alcohol DHI, testing recruitment, online data-collection and randomisation processes, with an embedded process evaluation...
2017: Pilot and Feasibility Studies
https://www.readbyqxmd.com/read/28876533/multi-objective-optimization-of-benzamide-derivatives-as-rho-kinase-inhibitors
#16
Giovanna Cardoso Gajo, Daniela Rodrigues Silva, Stephen J Barigye, Elaine Fontes Ferreira da Cunha
Despite recent advances in Computer Aided Drug Discovery and High Throughput Screening, the attrition rates of drug candidates continue to be high, underscoring the inherent complexity of the drug discovery paradigm. Indeed, a compromise between several objectives is often required to obtain successful clinical drugs. The present manuscript details a multi-objective workflow that integrates the 4D-QSAR and molecular docking methods in the simultaneous modeling of the Rho Kinase inhibitory activity and acute toxicity of Benzamide derivatives...
September 6, 2017: Molecular Informatics
https://www.readbyqxmd.com/read/28873095/longistyline-c-acts-antidepressant-in-vivo-and-neuroprotection-in-vitro-against-glutamate-induced-cytotoxicity-by-regulating-nmdar-nr2b-erk-pathway-in-pc12-cells
#17
Yamin Liu, Ning Zhao, Chenchen Li, Qi Chang, Xinmin Liu, Yonghong Liao, Ruile Pan
Depressive disorder is a common psychiatric disease which ranks among the leading cause of disability worldwide. The antidepressants presently used had low cure rate and caused a variety of side-effects. The screening of antidepressant drugs is usually used classic behavioural tests and neuroprotective strategy. Longistyline C, a natural stilbene isolated from the leaves of Cajanuscajan (L.) Millsp, was firstly investigated the antidepressant effect using animal behavioural tests, and studied the neuroprotection and its possible signaling pathways on glutamate-induced injury in PC12 cells...
2017: PloS One
https://www.readbyqxmd.com/read/28871151/time-resolved-pharmacological-studies-using-automated-on-line-monitoring-of-five-parallel-suspension-cultures
#18
Ala A Alhusban, Michael C Breadmore, Nuri Gueven, Rosanne M Guijt
Early stage pharmacological studies rely on in vitro methodologies for screening and testing compounds. Conventional assays based on endpoint measurements provide limited information because the lack in temporal resolution may not determine the pharmacological effect at its maximum. We developed an on-line, automated system for near real-time monitoring of extracellular content from five parallel suspension cultures, combining cell density measurements with a high-resolution separations every 12 minutes for 4 days...
September 4, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28867497/bictegravir-emtricitabine-and-tenofovir-alafenamide-versus-dolutegravir-abacavir-and-lamivudine-for-initial-treatment-of-hiv-1-infection-gs-us-380-1489-a-double-blind-multicentre-phase-3-randomised-controlled-non-inferiority-trial
#19
Joel Gallant, Adriano Lazzarin, Anthony Mills, Chloe Orkin, Daniel Podzamczer, Pablo Tebas, Pierre-Marie Girard, Indira Brar, Eric S Daar, David Wohl, Jürgen Rockstroh, Xuelian Wei, Joseph Custodio, Kirsten White, Hal Martin, Andrew Cheng, Erin Quirk
BACKGROUND: Integrase strand transfer inhibitors (INSTIs) are recommended components of initial antiretroviral therapy with two nucleoside reverse transcriptase inhibitors. Bictegravir is a novel, potent INSTI with a high in-vitro barrier to resistance and low potential as a perpetrator or victim of clinically relevant drug-drug interactions. We aimed to assess the efficacy and safety of bictegravir coformulated with emtricitabine and tenofovir alafenamide as a fixed-dose combination versus coformulated dolutegravir, abacavir, and lamivudine...
August 31, 2017: Lancet
https://www.readbyqxmd.com/read/28867267/testing-and-linkage-to-hiv-care-in-china-a-cluster-randomised-trial
#20
Zunyou Wu, Zhenzhu Tang, Yurong Mao, Paul Van Veldhuisen, Walter Ling, David Liu, Zhiyong Shen, Roger Detels, Guanghua Lan, Lynda Erinoff, Robert Lindblad, Diane Gu, Houlin Tang, Lian Hu, Qiuying Zhu, Li Lu, Neal Oden, Albert L Hasson, Yan Zhao, Jennifer M McGoogan, Xianmin Ge, Nanci Zhang, Keming Rou, Jinhui Zhu, Hui Wei, Cynthia X Shi, Xia Jin, Jian Li, Julio S G Montaner
BACKGROUND: Multistage, stepwise HIV testing and treatment procedures can result in lost opportunities to provide timely antiretroviral therapy (ART). Incomplete engagement of patients along the care cascade translates into high preventable mortality. We aimed to identify whether a structural intervention to streamline testing and linkage to HIV health care would improve testing completeness, ART initiation, and viral suppression and reduce mortality. METHODS: We did a cluster-randomised, controlled trial in 12 hospitals in Guangxi, China...
August 31, 2017: Lancet HIV
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