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Esophageal resection

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https://www.readbyqxmd.com/read/29332349/characteristics-and-clinical-significance-of-recurrent-laryngeal-nerve-lymph-node-metastasis-in-esophageal-squamous-cell-carcinoma
#1
Longfei Ma, Jiaqing Xiang, Yawei Zhang, Hong Hu, Rongrong Shao, Dong Lin
PURPOSE: The recurrent laryngeal nerve lymph nodes (RLN LNs) are among the most common metastatic sites in esophageal cancer, and the dissection of these lymph nodes (LNs) is considered beneficial. The purpose of this study was to evaluate the characteristics of RLN LN metastases from esophageal squamous cell carcinoma, and the effects of these metastases on the prognosis of patients. In addition, we aimed to determine the reasonable range of dissection of regional LNs. METHODS: The clinical data from 348 patients who underwent resection for esophageal carcinoma were retrospectively analyzed...
November 2017: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/29331036/prognostic-significance-of-mir-21-and-pdcd4-in-patients-with-stage-ii-esophageal-carcinoma-after-surgical-resection
#2
Jiandong Zhang, Lei Ma, Daimeng Shi, Zhen Zhang, Chuanshan Yao, Xulin Zhao, Quanxiao Xu, Penghao Wen, Limin He
Many studies have shown that randomized clinical trial with long-term follow-up found no improvement in stage II esophageal carcinoma (EC) patients receiving preoperative neoadjuvant chemoradiotherapy or chemotherapy treatment, this limitation underscored the urgent need for novel and reliable biomarkers for prognosis and prediction in stage II EC. miR-21 is frequently over-expressed while programmed cell death 4 (PDCD4) is often down-regulated in solid tumors. This study aimed to investigate the clinicopathological and prognostic significance of miR-21 and PDCD4 expression and to elucidate any correlation between miR-21 and PDCD4 expression in stage II EC patients...
January 13, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29327976/endoscopic-treatment-of-transesophageal-echocardiography-induced-esophageal-perforation
#3
Till Herbold, Seung-Hun Chon, Peter Grimminger, Martin K H Maus, Henner Schmidt, Hans Fuchs, Sebastian Brinkmann, Marc Bludau, Christian Gutschow, Wolfgang Schröder, Arnulf H Hölscher, Jessica M Leers
BACKGROUND: Perforation of the esophagus is the most severe complication of transesophageal echocardiography (TEE) and can lead to mediastinitis, pleural empyema, or peritonitis. Currently, the majority of patients receive operative treatment with only 6% treated endoscopically. We report our experience with endoscopic and conservative approaches. METHODS: We retrospectively reviewed all patients treated for esophageal perforation and included all patients with perforation caused by TEE...
January 12, 2018: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://www.readbyqxmd.com/read/29318416/air-bubble-sign-a-new-screening-method-for-anastomotic-leakage-after-esophagectomy-for-esophageal-cancer
#4
Yoshiaki Shoji, Hiroya Takeuchi, Kazumasa Fukuda, Rieko Nakamura, Norihito Wada, Hirofumi Kawakubo, Yuko Kitagawa
BACKGROUND: Contrast esophagography often is performed to screen for anastomotic leakage (AL) after esophagectomy. However, its sensitivity remains low. Adverse events also have been reported. This report describes a new screening method to detect AL on computed tomography (CT) after esophagectomy. METHODS: From January 2012 to December 2015, 185 patients with esophageal cancer underwent surgical resection at the authors' institution. The study comparatively reviewed patient characteristics, surgical outcomes, and findings from postoperative CT images and contrast esophagrams of 142 patients who underwent esophagectomy followed by primary gastric conduit reconstruction through a posterior mediastinum route...
January 9, 2018: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29318104/one-stage-laparoscopic-surgery-for-pulmonary-sequestration-and-hiatal-hernia-in-a-2-year-old-girl
#5
Hisayuki Miyagi, Shohei Honda, Hiromi Hamada, Masashi Minato, Momoko W Ara, Akinobu Taketomi
We herein report a case of one-stage laparoscopic surgery for extralobar pulmonary sequestration (EPS) and hiatal hernia. Our patient was a 2-year-old girl who was diagnosed as a mediastinal mass lesion. Postnatal computed tomography revealed that the mediastinal mass was an EPS. Two weeks after birth, the patient developed gastroesophageal reflux (GER), and esophagography showed a hiatal hernia. At 2 years of age, she underwent one-stage laparoscopic Nissen's fundoplication for GER with resection of the EPS in the posterior mediastinum...
January 2018: European Journal of Pediatric Surgery Reports
https://www.readbyqxmd.com/read/29311722/erratum-use-of-a-novel-submucosal-tunneling-and-endoscopic-resection-ster-technique-for-the-removal-of-an-esophageal-leiomyoma
#6
Madhusudhan R Sanaka, Malav P Parikh, Prashanthi N Thota, Niyati M Gupta, Siva Raja
This corrects the article DOI: 10.1038/ajg.2017.168.
January 2018: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/29311030/endoscopic-resection-of-a-rare-subepithelial-esophageal-hamartoma
#7
Arvind J Trindade, Cathy Fan, Bernard Bienstock
No abstract text is available yet for this article.
December 26, 2017: Digestive and Liver Disease
https://www.readbyqxmd.com/read/29310892/sarcopenia-is-not-associated-with-morbidity-mortality-or-recurrence-after-esophagectomy-for-cancer
#8
Steve R Siegal, James P Dolan, Elizabeth N Dewey, Alexander R Guimaraes, Brandon H Tieu, Paul H Schipper, John G Hunter
BACKGROUND: Sarcopenia is associated with increased morbidity and mortality in hepatic, pancreatic and colorectal cancer. We examined the effect of sarcopenia on morbidity, mortality, and recurrence after resection for esophageal cancer. METHODS: Retrospective review of consecutive esophagectomies from 2010 to 2015. Computed tomography studies were analyzed for sarcopenia. Morbidity was analyzed using Fischer's test and survival data with Kaplan Meier curves. RESULTS: The sarcopenic group (n = 127) had lower BMI, later stage disease, and higher incidence of neoadjuvant radiation than those without sarcopenia (n = 46)...
January 4, 2018: American Journal of Surgery
https://www.readbyqxmd.com/read/29302739/comparison-of-endo-cut-mode-and-forced-coag-mode-for-the-formation-of-stricture-after-esophageal-endoscopic-submucosal-dissection-in-an-in-vivo-porcine-model
#9
Masamichi Arao, Ryu Ishihara, Yusuke Tonai, Taro Iwatsubo, Satoki Shichijyo, Noriko Matsuura, Hiroko Nakahira, Sachiko Yamamoto, Yoji Takeuchi, Koji Higashino, Noriya Uedo, Shinichi Nakatsuka
BACKGROUND AND STUDY AIM: Stricture is a major complication of esophageal endoscopic submucosal dissection (ESD) for superficial esophageal carcinoma. To date, various methods have been developed to prevent stricture. However, the mechanism by which different electrosurgical unit (ESU) modes affect the formation of post-ESD stricture has not been evaluated. This study aimed to compare the degree of stricture caused by two major ESU modes (ENDO CUT mode and FORCED COAG mode) in a porcine model...
January 4, 2018: Surgical Endoscopy
https://www.readbyqxmd.com/read/29299354/post-operative-radiotherapy-is-associated-with-improved-survival-in-esophageal-cancer-with-positive-surgical-margins
#10
Sarah J Gao, Henry S Park, Christopher D Corso, Charles E Rutter, Sajid A Khan, Kimberly L Johung
Background: The optimal treatment for early-stage esophageal cancer with positive surgical margins after an upfront esophagectomy is not well-defined. This study investigates the effect of post-operative radiotherapy (PORT) on overall survival (OS) in clinical stage I-II patients with positive margins. Methods: We identified patients diagnosed between 2004 and 2012 with clinical stage I-II esophageal carcinoma from the National Cancer Data Base (NCDB) who underwent an upfront esophagectomy...
December 2017: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/29290662/combined-thoracoscopic-and-endoscopic-surgery-for-a-large-esophageal-schwannoma
#11
Yu Onodera, Toru Nakano, Daisuke Takeyama, Shota Maruyama, Yusuke Taniyama, Tadashi Sakurai, Takahiro Heishi, Chiaki Sato, Takuro Kumagai, Takashi Kamei
A 47-year-old woman presented to our hospital with complaints of dysphagia. Esophagogastroduodenoscopy identified a submucosal tumor in the left wall of the esophagus that was diagnosed as a benign schwannoma on biopsy. Computed tomography revealed a tumor of length 60 mm in the thoracic esophagus, with its cranial edge at the level of the aortic arch. On endoscopy, a submucosal tunnel was created 40 mm proximal to the cranial edge of the tumor, and its oral end was dissected from the mucosal and muscular layers...
December 14, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29290655/endoscopic-ultrasound-staging-for-early-esophageal-cancer-are-we-denying-patients-neoadjuvant-chemo-radiation
#12
Carrie Luu, Marisa Amaral, Jason Klapman, Cynthia Harris, Khaldoun Almhanna, Sarah Hoffe, Jessica Frakes, Jose M Pimiento, Jacques P Fontaine
AIM: To evaluate the accuracy of endoscopic ultrasound (EUS) in early esophageal cancer (EC) performed in a high-volume tertiary cancer center. METHODS: A retrospective review of patients undergoing esophagectomy was performed and patients with cT1N0 and cT2N0 esophageal cancer by EUS were evaluated. Patient demographics, tumor characteristics, and treatment were reviewed. EUS staging was compared to surgical pathology to determine accuracy of EUS. Descriptive statistics was used to describe the cohort...
December 14, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29288659/the-learning-curve-for-robotic-mckeown-esophagectomy-in-patients-with-esophageal-cancer
#13
Hanlu Zhang, Longqi Chen, Zihao Wang, Yu Zheng, Yingcai Geng, Fuqiang Wang, Dan Liu, Andong He, Lin Ma, Yong Yuan, Yun Wang
BACKGROUND: Robot-assisted McKeown esophagectomy (RAME) is a promising but technically demanding procedure, so a learning curve should be defined to guide training and allow implementation of this technique. METHODS: This study retrospectively reviewed a prospectively collected data of 72 consecutive patients undergoing RAME by a single surgical team experienced in open and thoracolaparoscopic esophagectomy. The cumulative sum (CUSUM) method was used to analyse the learning curve...
December 27, 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29288614/laparoscopic-hipec-for-peritoneal-carcinomatosis-from-gastric-cancer-technique-and-early-outcomes-of-our-first-cases
#14
Irina Bălescu, Daniela Godoroja, Mircea Gongu, Victor Tomulescu, Cătălin Copăescu
Gastric cancer remains one of the most aggressive malignancies, being associated with very poor therapeutic outcomes, especially in the advanced disease patients. Due to this evidence, finding a better treatment, a better control and higher survival rates is the current scientific focus of the medical community. Once the benefits of cytoreductive surgery in association with intraperitoneal hyperthermy (HIPEC) have been widely demonstrated in patients presenting peritoneal carcinomatosis from colorectal or ovarian origin,attention was focused on the possible benefit of this method in patients diagnosed with peritoneal carcinomatosis with gastric origin...
November 2017: Chirurgia
https://www.readbyqxmd.com/read/29286915/upregulation-of-the-long-noncoding-rna-foxd2-as1-predicts-poor-prognosis-in-esophageal-squamous-cell-carcinoma
#15
Jie Bao, Chenjie Zhou, Jiaqing Zhang, Jiaqiang Mo, Qing Ye, Junming He, Jingfang Diao
BACKGROUND: The long non-coding RNA FOXD2-AS1 is highly expressed in non-small cell lung cancer and promotes malignant progression. However, the role of FOXD2-AS1 in esophageal squamous cell carcinoma (ESCC) is still unclear. OBJECTIVE: In this study, we examined the relationships between the expression level of FOXD2-AS1 and the outcome of ESCC patients. METHODS: Expression of FOXD2-AS1 was evaluated in cancer tissue and adjacent non-tumor tissues samples from 147 ESCC patients who received radical surgical resection using qRT-PCR...
December 15, 2017: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/29285642/association-of-delivery-system-integration-and-outcomes-for-major-cancer-surgery
#16
Jonathan Li, Zaojun Ye, James M Dupree, Brent K Hollenbeck, Hye Sung Min, Deborah Kaye, Lindsey A Herrel, David C Miller, Chad Ellimoottil
BACKGROUND: Integrated delivery systems (IDSs) are postulated to reduce spending and improve outcomes through successful coordination of care across multiple providers. Nonetheless, the actual impact of IDSs on outcomes for complex multidisciplinary care such as major cancer surgery is largely unknown. METHODS: Using 2011-2013 Medicare data, this study identified patients who underwent surgical resection for prostate, bladder, esophageal, pancreatic, lung, liver, kidney, colorectal, or ovarian cancer...
December 29, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29285315/cxcl8-derived-from-tumor-associated-macrophages-and-esophageal-squamous-cell-carcinomas-contributes-to-tumor-progression-by-promoting-migration-and-invasion-of-cancer-cells
#17
Masayoshi Hosono, Yu-Ichiro Koma, Nobuhisa Takase, Naoki Urakawa, Nobuhide Higashino, Kazuki Suemune, Himiko Kodaira, Mari Nishio, Manabu Shigeoka, Yoshihiro Kakeji, Hiroshi Yokozaki
Tumor-associated macrophages (TAMs) are involved in tumor progression and poor prognosis in several malignancies. We previously demonstrated the interaction between high numbers of infiltrating TAMs and poor prognosis in esophageal squamous cell carcinomas (ESCCs). To investigate the significance of TAMs in ESCC, we conducted a cDNA microarray analysis of peripheral blood monocytes (PBMo)-derived macrophages and PBMo-derived macrophages stimulated with conditioned media of TE-series ESCC cell lines (TAM-like PBMo-derived macrophages)...
December 1, 2017: Oncotarget
https://www.readbyqxmd.com/read/29282603/perioperative-risk-calculator-predicts-long-term-oncologic-outcome-for-patients-with-esophageal-carcinoma
#18
Masashi Takeuchi, Hiroya Takeuchi, Hirofumi Kawakubo, Eisuke Booka, Shuhei Mayanagi, Kazumasa Fukuda, Rieko Nakamura, Koichi Suda, Norihito Wada, Yuko Kitagawa
BACKGROUND: Few risk models have been provided to predict long-term prognosis after esophagectomy. This study investigated the reliability of a risk calculator as well as classification and regression trees analysis for predicting long-term prognosis after esophagectomy for esophageal cancer. METHODS: The study enrolled 438 patients who underwent esophagectomy at Keio University Hospital, Tokyo, Japan, between July 2000 and June 2016. Patients who underwent R0 or R1 resection or esophagectomy with combined resection of other organs were included...
December 28, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29279695/undiagnosed-esophageal-adenocarcinoma-presenting-as-multiple-brain-metastases
#19
Vincent Grzywacz, Ernie Balcueva
Brain metastases from gastrointestinal malignancies are exceedingly rare occurrences that carry a very poor prognosis. This holds especially true in cases where brain metastases from esophageal primaries are the initial presentation of a previously unidentified gastrointestinal malignancy. Our patient, a 60-year-old male with a past history of a right temporal teratoma, family history of breast cancer, and no smoking history, presented with a chief complaint of recurrent headaches. His history of present illness and physical examination included a two-month history of frontal headache, progressive fatigue, and unintentional weight loss...
September 2017: Case Reports in Oncology
https://www.readbyqxmd.com/read/29278885/egfr-and-akt1-overexpression-are-mutually-exclusive-and-associated-with-a-poor-survival-in-resected-gastric-adenocarcinomas
#20
Iacopo Petrini, Monica Lencioni, Enrico Vasile, Lorenzo Fornaro, Lorenzo Belluomini, Giulia Pasquini, Laura Ginocchi, Chiara Caparello, Gianna Musettini, Caterina Vivaldi, Sara Caponi, Sergio Ricci, Agenese Proietti, Gabriella Fontanini, Antonio Giuseppe Naccarato, Vincenzo Nardini, Stefano Santi, Alfredo Falcone
PURPOSE: The evaluation of molecular targets in gastric cancer has demonstrated the predictive role of HER2 amplification for trastuzumab treatment in metastatic gastric cancer. Besides HER2, other molecular targets are under evaluation in metastatic gastric tumors. However, very little is known about their role in resected tumors. We evaluated the expression of HER2, EGFR, MET, AKT1 and phospho-mTOR in resected stage II-III adenocarcinomas. METHODS: Ninety-two patients with resected stomach (63%) or gastro-esophageal adenocarcinomas (27%) were evaluated...
December 15, 2017: Cancer Biomarkers: Section A of Disease Markers
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