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Esophageal resection

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https://www.readbyqxmd.com/read/28931046/clinical-relevance-of-histologic-subtypes-in-locally-advanced-esophageal-carcinoma-treated-with-pre-operative-chemoradiotherapy-experience-of-a-monographic-oncologic-centre
#1
Maria Saigí, Marc Oliva, Luisa Aliste, Mariona Calvo, Gloria Hormigo, Òlbia Serra, Anna Boladeras, Leandre Farran, Javier Robles, Gloria Creus, Ma José Paúles, Joan B Gornals, Eugenia de Lama, Josep Ma Borràs, Núria Sala, Maica Galán
BACKGROUND: Locally advanced esophageal carcinoma (LAEC) represents less than 30% of all diagnosed esophageal carcinoma worldwide. The standard of care for resectable tumours consists of preoperative chemoradiotherapy (CRT) followed by surgery. Despite the curative intent, the prognosis is still poor mainly due to relapse. A multidisciplinary approach is required in order to optimize the therapeutic strategy and follow-up. Differences in outcomes between the two main histological subtypes, adenocarcinoma (ADC) and squamous cell carcinoma (SCC), have been reported...
2017: PloS One
https://www.readbyqxmd.com/read/28927038/effects-of-neoadjuvant-chemotherapy-combined-with-radiotherapy-in-patients-with-advanced-esophageal-carcinoma
#2
Yu Liu, Deyao Xie, Chang Li, Chaoxi Lin, Jun Zhao
We analyzed the improvement of survival time and the effects of neoadjuvant chemotherapy combined with radiotherapy on treating patients with advanced esophageal carcinoma. Retrospectively, 43 patients were selected with esophageal carcinoma who were administered neoadjuvant chemotherapy combined with radiotherapy. According to gender, and tumor staging, the nearest neighbor matching was carried out. Eighty-six patients (1:2) who received neoadjuvant chemotherapy and 129 patients (1:3) who underwent surgery only were taken and compared for clinical outcomes...
September 2017: Oncology Letters
https://www.readbyqxmd.com/read/28924592/tumor-location-is-a-risk-factor-for-lymph-node-metastasis-in-superficial-barrett-s-adenocarcinoma
#3
Masayoshi Yamada, Ichiro Oda, Hirohito Tanaka, Seiichiro Abe, Satoru Nonaka, Haruhisa Suzuki, Shigetaka Yoshinaga, Aya Kuchiba, Kazuo Koyanagi, Hiroyasu Igaki, Hirokazu Taniguchi, Shigeki Sekine, Yutaka Saito, Yuji Tachimori
BACKGROUND AND STUDY AIMS : Endoscopic treatment is indicated for superficial Barrett's adenocarcinoma (BA) with a negligible risk of lymph node metastasis (LNM). However, risk factors associated with LNM in superficial BA are still not well characterized. The aim of the current study was to clarify risk factors for LNM of superficial BA. PATIENTS AND METHODS : A retrospective study was conducted in 87 consecutive patients with BA that was resected at National Cancer Center Hospital, Tokyo, Japan between 1990 and 2013...
September 2017: Endoscopy International Open
https://www.readbyqxmd.com/read/28924068/-endovascular-treatment-for-carotid-blowout-syndrome-after-radiation-for-esophageal-cancer-a-case-report
#4
Shigefumi Takahashi, Tomohiro Kawaguchi, Kuniyasu Niizuma, Atsuhiro Nakagawa, Miki Fujimura, Takenori Ogawa, Yukio Katori, Teiji Tominaga
Here, we discuss a case of carotid blowout syndrome successfully treated with endovascular parent artery occlusion. A 71-year-old woman underwent treatment for esophageal cancer resection, followed by 50-Gy radiotherapy, 19 years prior. Due to local recurrence, she underwent 66- and 72-Gy radiation treatments at 2 and 4 years after the initial treatment, respectively. Afterward, tracheostomy and enterostomy were performed. This time, she was transported to our emergency department because of acute eruptive bleeding from the tracheal tube...
September 2017: No Shinkei Geka. Neurological Surgery
https://www.readbyqxmd.com/read/28918544/tumor-regression-grading-of-gastrointestinal-cancers-after-neoadjuvant-therapy
#5
REVIEW
Rupert Langer, Karen Becker
Neoadjuvant therapy has been successfully introduced in the treatment of locally advanced gastrointestinal malignancies, particularly esophageal, gastric, and rectal cancers. The effects of preoperative chemo- or radiochemotherapy can be determined by histopathological investigation of the resection specimen following this treatment. Frequent histological findings after neoadjuvant therapy include various amounts of residual tumor, inflammation, resorptive changes with infiltrates of foamy histiocytes, foreign body reactions, and scarry fibrosis...
September 16, 2017: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/28916920/does-delayed-esophagectomy-after-endoscopic-resection-affect-outcomes-in-patients-with-stage-t1-esophageal-cancer-a-propensity-score-based-analysis
#6
Shengfei Wang, Yangle Huang, Juntao Xie, Lingdun Zhuge, Longlong Shao, Jiaqing Xiang, Yawei Zhang, Yihua Sun, Hong Hu, Sufeng Chen, Toni Lerut, James D Luketich, Jie Zhang, Haiquan Chen
BACKGROUND: Although endoscopic resection (ER) may be sufficient treatment for early-stage esophageal cancer, additional treatment is recommended when there is a high risk of cancer recurrence. It is unclear whether delaying esophagectomy by performing and assessing the success of ER affects outcomes as compared with immediate esophagectomy without ER. Additionally, long-term survival after sequential ER and esophagectomy required further investigation. METHODS: Between 2011 and 2015, 48 patients with stage T1 esophageal cancer underwent esophagectomy after ER with curative intent at our institution...
September 15, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/28916906/neoadjuvant-versus-definitive-chemoradiotherapy-for-locally-advanced-esophageal-cancer-outcomes-and-patterns-of-failure
#7
Matthias Felix Haefner, Kristin Lang, Vivek Verma, Stefan Alexander Koerber, Lorenz Uhlmann, Juergen Debus, Florian Sterzing
PURPOSE: Randomized trials examining neoadjuvant chemoradiotherapy followed by surgical resection (nCRT-S) and definitive CRT (dCRT) for esophageal cancer (EC) patients are hampered by use of nonstandard treatment paradigms. Outcomes of nCRT-S versus dCRT in a more common patient population are lacking. We investigated local control and survival, evaluated clinical factors associated with endpoints, and assessed patterns of failure between these cohorts. METHODS: We retrospectively analyzed 130 patients with locally advanced EC receiving either dCRT or nCRT-S at our institution from 2000-2012...
September 15, 2017: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/28903446/application-of-embolization-microspheres-in-interventional-therapy-of-malignant-non-hypervascular-tumor-of-liver
#8
Huanzhang Niu, Tingwei Du, Quanping Xiao, Xin Hu, Dongmin Li, Chao Wang, Wanqin Gao, Taohong Xing, Xiangmei Xu
OBJECTIVE: To investigate the efficacy and safety of transarterial embolization (TAE) using embolization microspheres in the treatment of non-hypervascular malignant liver tumors. METHODS: Patients with malignant non-hypervascular liver tumors, who were treated with TAE using embolization microspheres, were selected and analyzed retrospectively. The technical success rate, tumor response, and complications were assessed. RESULTS: Six patients were included in the study: 1 patient each with hepatocellular-cholangiocarcinoma, intrahepatic cholangiocarcinoma, hepatic metastasis after resection of common bile duct carcinoma, liver metastasis from colon cancer, liver metastasis from esophageal cancer, and liver metastasis from pancreatic cancer...
August 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28903420/high-expression-of-ki-67-is-an-independent-favorable-prognostic-factor-for-esophageal-small-cell-carcinoma
#9
Han-Yu Deng, Zi-Hang Chen, Zhi-Qiang Wang, Yun-Cang Wang, En-Min Li, Li-Yan Xu, Yi-Dan Lin, Long-Qi Chen
BACKGROUND: The prognostic value of Ki-67 expression in small cell carcinoma of the esophagus (SCCE) has not been explored in any previous studies. Therefore, we conducted this retrospective study to investigate the prognostic role of Ki-67 in SCCE for the first time. RESULTS: A total of 44 patients were included for analysis. The baseline clinicopathological data of these SCCE patients shared similar characteristics with previous studies. Ten patients were at stage I, 17 at stage II, and the remaining 17 were at stage III...
August 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28901002/-current-research-status-and-progress-of-primary-esophageal-gastrointestinal-stromal-tumors-in-china
#10
Guoren Li, Jianhua Dai
Primary esophageal gastrointestinal stromal tumors (GIST) is a rare independent disease with clinicopathological and molecular features different from other mesenchymal tumors. Authors searched and reviewed associated reports and summarized the morbidity trends, characteristics, diagnosis and treatment of esophageal GIST in China. Data show that the incidence and detection rate of esophageal GIST presents the rising trend. Imaging has some characteristics. Ultrasonography and CT are main methods and effective examinations to detect and prompt diagnosis of esophageal GIST...
September 25, 2017: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/28900998/-associated-factors-of-postoperative-relapse-and-metastasis-in-pt1bn0m0-pt4an0m0-thoracic-esophageal-squamous-cell-carcinoma
#11
Wenbiao Pan, Yangwei Xiang, Zhitao Gu, Chunyu Ji, Teng Mao, Wentao Fang
OBJECTIVE: To investigate the associated high risk factors of postoperative relapse and metastasis for patients with confined tumors (grade pT1b-4a) without lymph-node metastases (pN0) in thoracic esophageal squamous cell carcinoma (ESCC). METHODS: Clinicopathological and follow up data of ESCC patients undergoing radical surgical resection as primary treatment in the Department of Thoracic Surgery, Shanghai Chest Hospital between January 2004 and December 2012 from Hospital Database were retrospectively collected...
September 25, 2017: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/28900830/transhiatal-vs-transthoracic-esophagectomy-a-nsqip-analysis-of-postoperative-outcomes-and-risk-factors-for-morbidity
#12
Francisco Schlottmann, Paula D Strassle, Marco G Patti
BACKGROUND: Both transhiatal esophagectomy (THE) and transthoracic esophagectomy (TTE) are accepted procedures for esophageal resection. We aimed to compare postoperative outcomes between these procedures and identify risk factors for morbidity. METHODS: A retrospective analysis was performed using the American College of Surgeons National Surgical Quality Improvement Program database. Adult patients who underwent THE or TTE between 2005 and 2014 were included. Postoperative morbidity, length of stay, and 30-day mortality were compared...
September 12, 2017: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/28899721/clinical-challenges-and-images-in-gastroenterology-endoscopic-resection-of-esophageal-mucosal-bridge
#13
Abhilash Perisetti, Debdeep Banerjee, Benjamin Tharian
No abstract text is available yet for this article.
September 9, 2017: Gastroenterology
https://www.readbyqxmd.com/read/28894820/indwelling-voice-prosthesis-insertion-after-total-pharyngolaryngectomy-with-free-jejunal-reconstruction
#14
Hirofumi Fukushima, Takeharu Kanazawa, Kazuyoshi Kawabata, Hiroki Mitani, Hiroyuki Yonekawa, Toru Sasaki, Wataru Shimbashi, Akira Seto, Ryousuke Kamiyama, Kiyoshi Misawa, Takahiro Asakage
OBJECTIVES: Total pharyngolaryngectomy with free jejunal reconstruction is often performed in patients with hypopharyngeal carcinoma. However, postoperative speechlessness significantly decreases patient quality of life. We investigated whether Provox® insertion could preserve speech after total pharyngolaryngectomy with free jejunal reconstruction. STUDY DESIGN: Retrospective chart review. METHODS: A total of 130 cases of secondary Provox® insertions after total pharyngolaryngectomy with free jejunal reconstruction were analyzed...
February 2017: Laryngoscope Investigative Otolaryngology
https://www.readbyqxmd.com/read/28892579/elevated-expression-of-%C3%AE-np63-in-advanced-esophageal-squamous-cell-carcinoma
#15
Yuji Kumakura, Susumu Rokudai, Misaki Iijima, Bolag Altan, Tomonori Yoshida, Halin Bao, Takehiko Yokobori, Makoto Sakai, Makoto Sohda, Tatsuya Miyazaki, Masahiko Nishiyama, Hiroyuki Kuwano
This study aims to explore the expression level of ΔNp63 in esophageal squamous cell carcinoma (ESCC). To investigate the association between ΔNp63 (p40) expression and ESCC biology, we compared the levels of ΔNp63 expression in normal and tumor tissues, with a specific focus on the diagnostic value of ΔNp63 in ESCC. We analyzed 160 consecutive patients with ESCC who underwent surgical resection without neoadjuvant-chemotherapy at Gunma University Hospital between September 2000 and January 2010. The clinicopathological characteristics and survival of patients were subclassified based on the expression of ΔNp63 as determined by immunohistochemistry, demonstrating that ΔNp63 was highly expressed in 75...
September 11, 2017: Cancer Science
https://www.readbyqxmd.com/read/28887066/neoadjuvant-chemoradiation-is-associated-with-improved-overall-survival-in-older-patients-with-esophageal-cancer
#16
David M Guttmann, Nandita Mitra, James M Metz, John Plastaras, Weiwei Feng, Samuel Swisher-McClure
OBJECTIVES: The aim of this study was to characterize outcomes associated with neoadjuvant chemoradiation prior to esophagectomy, compared to esophagectomy alone, in older patients with esophageal cancer. MATERIALS AND METHODS: We conducted an observational cohort study in patients ≥70years with locally-advanced esophageal cancer undergoing esophagectomy ± neoadjuvant chemoradiation between 2006 and 2012 using the National Cancer Database. A Cox proportional hazards model with inverse probability of treatment weighting (IPTW) using the propensity score was developed to assess the association between trimodality therapy and overall survival...
September 5, 2017: Journal of Geriatric Oncology
https://www.readbyqxmd.com/read/28885686/refining-the-predictors-of-outcome-in-patients-with-resectable-esophageal-cancer
#17
Nabil F Saba
No abstract text is available yet for this article.
September 8, 2017: Cancer
https://www.readbyqxmd.com/read/28881911/vascular-density-of-superficial-esophageal-squamous-cell-carcinoma-determined-by-direct-observation-of-resected-specimen-using-narrow-band-imaging-with-magnifying-endoscopy
#18
D Kikuchi, T Iizuka, S Hoteya, K Nomura, Y Kuribayashi, T Toba, M Tanaka, S Yamashita, T Furuhata, A Matsui, T Mitani, N Inoshita, M Kaise
Observation of the microvasculature using narrow band imaging (NBI) with magnifying endoscopy is useful for diagnosing superficial squamous cell carcinoma. Increased vascular density is indicative of cancer, but not many studies have reported differences between cancerous and noncancerous areas based on an objective comparison. We observed specimens of endoscopic submucosal dissection (ESD) using NBI magnification, and determined the vascular density of cancerous and noncancerous areas. A total of 25 lesions of esophageal squamous cell carcinoma that were dissected en bloc by ESD between July 2013 and December 2013 were subjected to NBI magnification...
November 1, 2017: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://www.readbyqxmd.com/read/28881907/pilot-study-on-the-feasibility-of-sentinel-node-navigation-surgery-in-combination-with-thoracolaparoscopic-lymphadenectomy-without-esophagectomy-in-early-esophageal-adenocarcinoma-patients
#19
H T Künzli, M I van Berge Henegouwen, S S Gisbertz, S van Esser, S L Meijer, R J Bennink, M J Wiezer, C A Seldenrijk, J J G H M Bergman, B L A M Weusten
High-risk submucosal esophageal adenocarcinoma's might be treated curatively by means of radical endoscopic resection, followed by thoracolaparoscopic lymphadenectomy without concomitant esophagectomy. A preclinical study has shown the feasibility and safety of this approach; however, no studies are performed in a clinical setting. In addition, sentinel node navigation surgery could be valuable in tailoring the extent of the lymphadenectomy. This study aimed to evaluate the feasibility and safety of thoracolaparoscopic lymphadenectomy without esophagectomy (phase I) and sentinel node navigation surgery (phase II) in patients with early esophageal adenocarcinoma...
November 1, 2017: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://www.readbyqxmd.com/read/28881898/performance-characteristics-of-optical-coherence-tomography-in-assessment-of-barrett-s-esophagus-and-esophageal-cancer-systematic-review
#20
D R Kohli, M L Schubert, A M Zfass, T U Shah
Optical coherence tomography (OCT) can generate high-resolution images of the esophagus that allows cross-sectional visualization of esophageal wall layers. We conducted a systematic review to assess the utility of OCT for diagnosing of esophageal intestinal metaplasia (IM; Barrett's esophagus BE)), dysplasia, cancer and staging of early esophageal cancer. English language human observational studies and clinical trials published in PubMed and Embase were included if they assessed any of the following: (i) in-vivo features and accuracy of OCT at diagnosing esophageal IM, sub-squamous intestinal metaplasia (SSIM), dysplasia, or cancer, and (ii) accuracy of OCT in staging esophageal cancer...
November 1, 2017: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
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