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https://www.readbyqxmd.com/read/29679661/evolutionary-compromises-to-metabolic-toxins-ammonia-and-urea-tolerance-in-drosophila-suzukii-and-drosophila-melanogaster
#1
Virginia Belloni, Alessia Galeazzi, Giulia Bernini, Mauro Mandrioli, Elisabetta Versace, Albrecht Haase
The invasive pest Drosophila suzukii has evolved morphological and behavioural adaptations to lay eggs under the skin of fresh fruits. This results in severe damage to a wide range of small fruits. Drosophila suzukii females typically lay few eggs per fruit, preferring healthy fruits. Hence, larvae are exposed to a reduced amount of nitrogenous waste. Differently, the innocuous Drosophila melanogaster lays eggs on fermented fruits already infested by conspecifics, with larvae developing in a crowded environment with the accumulation of nitrogenous waste such as ammonia and urea...
April 18, 2018: Physiology & Behavior
https://www.readbyqxmd.com/read/29679632/dietary-habits-associated-with-reduced-insulin-resistance-the-nagahama-study
#2
Kaori Ikeda, Tosiya Sato, Takeo Nakayama, Daisuke Tanaka, Kazuaki Nagashima, Fumika Mano, Erina Joo, Shimpei Fujimoto, Yoshimitsu Takahashi, Shinji Kosugi, Akihiro Sekine, Yasuharu Tabara, Fumihiko Matsuda, Nobuya Inagaki
AIMS: To investigate the association between insulin resistance assessed by a homeostasis model and dietary habits. METHODS: Cross-sectional analysis using a community-based cohort, the Nagahama Prospective Cohort for Comprehensive Human Bioscience. Multiple linear regression analysis was performed with log HOMA-IR or log HOMA- β as the dependent variable and 20 dietary habits, tobacco smoking, medical history, family medical history of diabetes, age and BMI as the simultaneous independent variables in each sex separately...
April 18, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29679266/changes-in-content-of-triterpenoids-and-polysaccharides-in-ganoderma-lingzhi-at-different-growth-stages
#3
Toshinori Nakagawa, Qinchang Zhu, Sonam Tamrakar, Yhiya Amen, Yasuhiro Mori, Hiroto Suhara, Shuhei Kaneko, Hiroko Kawashima, Kotaro Okuzono, Yoshiyuki Inoue, Koichiro Ohnuki, Kuniyoshi Shimizu
Ganoderma lingzhi is a traditional medicinal mushroom, and its extract contains many bioactive compounds. Triterpenoids and polysaccharides are the primary bioactive components that contribute to its medicinal properties. In this study, we quantified 18 triterpenoids, total triterpenoid content and total polysaccharide content in the ethanol and water extracts of G. lingzhi at different growth stages. Triterpenoids were quantified by liquid chromatograph-tandem mass spectrometry in the multiple-reaction-monitoring mode...
April 20, 2018: Journal of Natural Medicines
https://www.readbyqxmd.com/read/29679203/a-window-into-extreme-longevity-the-circulating-metabolomic-signature-of-the-naked-mole-rat-a-mammal-that-shows-negligible-senescence
#4
Kaitlyn N Lewis, Nimrod D Rubinstein, Rochelle Buffenstein
Mouse-sized naked mole-rats (Heterocephalus glaber), unlike other mammals, do not conform to Gompertzian laws of age-related mortality; adults show no age-related change in mortality risk. Moreover, we observe negligible hallmarks of aging with well-maintained physiological and molecular functions, commonly altered with age in other species. We questioned whether naked mole-rats, living an order of magnitude longer than laboratory mice, exhibit different plasma metabolite profiles, which could then highlight novel mechanisms or targets involved in disease and longevity...
April 20, 2018: GeroScience
https://www.readbyqxmd.com/read/29678976/fostering-active-living-and-healthy-eating-through-understanding-physical-activity-and-dietary-behaviours-of-arabic-speaking-adults-a-cross-sectional-study-from-the-middle-east
#5
Tam Truong Donnelly, Tak Shing Fung, Al-Anoud Bint Mohammad Al-Thani
OBJECTIVES: Physical inactivity and unhealthy diets increase the risk for diabetes, cardiovascular diseases and cancer. Many people in Qatar are sedentary and consume diets high in fats, salt and sugar. The purpose of this study was to determine physical activity levels, food habits and understand the variables that might predict physical activity and healthy eating behaviours among Arabic-speaking adults living in the State of Qatar. SETTING: A cross-sectional community-based survey was conducted with 1606 Arab adults ≥18 years of age from March 2013 to June 2015...
April 20, 2018: BMJ Open
https://www.readbyqxmd.com/read/29678768/safety-assessment-of-ethanolic-extract-of-olea-europaea-l-leaves-after-acute-and-subacute-administration-to-wistar-rats
#6
Camille Gaube Guex, Fernanda Ziegler Reginato, Kássia Caroline Figueredo, Andreia Regina Haas da Silva, Fernanda Brum Pires, Roberta da Silva Jesus, Cibele Lima Lhamas, Gilberti Helena Hübscher Lopes, Liliane de Freitas Bauermann
Olea europaea L., popularly known as olive, is a plant widely used worldwide. Its leaves, fruit and oil are extensively consumed and present important pharmacological properties. However, studies regarding the toxicity of olive leaves are still limited in the literature. Therefore, the aim of the study was to investigate acute and subacute oral toxicities of the ethanolic extract of olive leaves (EEO) in Wistar rats through histopathology and biochemical and hematological parameters. Acute toxicity was assessed using a single dose of 2000 mg/kg of EEO administered by oral gavage to male and female rats...
April 17, 2018: Regulatory Toxicology and Pharmacology: RTP
https://www.readbyqxmd.com/read/29678666/biochemical-deficits-and-cognitive-decline-in-brain-aging-intervention-by-dietary-supplements
#7
REVIEW
Jit Poddar, Munmun Pradhan, Gargi Ganguly, Sasanka Chakrabarti
The aging of brain in the absence of neurodegenerative diseases, usually called non-pathological brain aging or normal cognitive aging, is characterized by an impairment of memory and cognitive functions. The underlying cellular and molecular changes in the aging brain that include oxidative damage, mitochondrial impairment, changes in glucose-energy metabolism and neuroinflammation have been reported widely from animal experiments and human studies. The cognitive deficit of non-pathological brain aging is the resultant of such inter-dependent and reinforcing molecular pathologies which have striking similarities with those operating in Alzheimer's disease which causes progressive, irreversible and a devastating form of dementia and cognitive decline in the elderly people...
April 17, 2018: Journal of Chemical Neuroanatomy
https://www.readbyqxmd.com/read/29677543/garcinia-morella-fruit-a-promising-source-of-antioxidant-and-anti-inflammatory-agents-induces-breast-cancer-cell-death-via-triggering-apoptotic-pathway
#8
Bhaswati Choudhury, Raghuram Kandimalla, R Elancheran, Rupjyoti Bharali, Jibon Kotoky
A rapid rise in cancer cases worldwide, especially breast cancer in females, instigates the need for more effective and less side effect causing drugs from natural origin. Thereby, in the present study, Garcinia morella fruit was investigated for antioxidant, anti-inflammatory and anti-breast cancer activity. Preliminary antioxidant and anticancer evaluation of different fractions and crude methanol extract of G. morella fruit suggested chloroform fraction as the bioactive fraction. Time course analysis (by 24 h, 48 h and 72 h) of the bioactive fraction (1...
April 17, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29677459/hepatoprotective-and-antioxidant-properties-of-the-aqueous-extract-of-olea-europaea-leaves-against-diclofenac-induced-liver-damages-in-mice
#9
Rawya Soussi, Najla Hfaiedh, Fatma Guesmi, Mohsen Sakly, Khémais Ben Rhouma
Historically, olive tree "Olea europaea" is one of the most important fruit trees in Mediterranean countries. Several studies suggest that olive leaf is a significant source of bioactive phenolic compounds compared to olive oil and fruits. This study was undertaken to investigate, the protective effect of the aqueous extract of « Chemlali » olive leaves against diclofenac-induced damages in liver and haematological alterations in swiss albinos mice. For this, twenty-eight mice were divided into four groups: a control group, a diclofenac-treated group (2...
April 20, 2018: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/29677447/prediction-models-for-assessing-lycopene-in-open-field-cultivated-tomatoes-by-means-of-a-portable-reflectance-sensor-cultivar-and-growing-season-effects
#10
Leonardo Ciaccheri, Lorenza Tuccio, Andrea A Mencaglia, Kalina Maja Sikorska-Zimny, Ewelina Hallmann, Artur Kowalski, Anna Grazia Mignani, Stanislaw Kaniszewski, Giovanni Agati
Reflectance spectroscopy represents a useful tool for the non-destructive assessment of tomato lycopene, even in the field. For this reason, a compact, low-cost, LED-based sensor has been developed to measure reflectance in the 400-750 nm spectral range. It was calibrated against wet chemistry and evaluated by Partial Least Squares (PLS) regression analyses. The lycopene prediction models were defined for two open-field cultivated red-tomato varieties: the processing oblong tomatoes of the cv. Calista (average weight: 76 g) and the fresh-consumption round tomatoes of the cv...
April 20, 2018: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29677267/the-short-lived-epidemic-of-botulism-from-commercially-canned-foods-in-the-united-states-1919-to-1925
#11
Powel Kazanjian
In 1919, three deadly outbreaks of botulism caused by consumption of canned olives packed in California captured national headlines. In all of the outbreaks, which occurred in separate locales, unsuspecting people died after consuming tainted food during a banquet or family meal. The press's sensational portrayal of canned food as hazardous aroused alarm among consumers at a time when commercial canning was becoming more common. Intent on restoring the image of their product as safe and wholesome, canning industry leaders funded a "botulism commission" of scientific experts in 1919 to investigate how to systematically eliminate the threat of botulism that had imperiled their business...
April 17, 2018: Annals of Internal Medicine
https://www.readbyqxmd.com/read/29677110/dietary-treatment-of-metabolic-acidosis-in-chronic-kidney-disease
#12
REVIEW
Roswitha Siener
Chronic kidney disease and reduced glomerular filtration rate are risk factors for the development of chronic metabolic acidosis. The prevention or correction of chronic metabolic acidosis has been found to slow progression of chronic kidney disease. Dietary composition can strongly affect acid⁻base balance. Major determinants of net endogenous acid production are the generation of large amounts of hydrogen ions, mostly by animal-derived protein, which is counterbalanced by the metabolism of base-producing foods like fruits and vegetables...
April 20, 2018: Nutrients
https://www.readbyqxmd.com/read/29676913/glutathione-gsh-reduces-cytotoxicity-evoked-by-patulin-pat-in-hek293-cells-by-preventing-oxidative-damage-and-mitochondrial-apoptotic-pathway
#13
Xiaorui Wang, Chengni Jin, Yujie Zhong, Xuan Li, Jiahui Han, Wei Xue, Peng Wu, Xiaodong Xia, Xiaoli Peng
Patulin (PAT) is a mycotoxin which frequently detected in moldy fruits and fruit products. This study investigated the protective role of glutathione (GSH), a antioxidant agent, against PAT induced cytotoxicity and its potential mechanisms in HEK293 cells. The obtained results showed that addition of GSH significantly reduced cell viability and apoptosis induced by PAT. Additionally, GSH decreased intracellular ROS and mitochondrial ROS overproduction, suppressed the decline of mitochondrial membrane potential, and maintained the cellular ATP content...
April 20, 2018: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29676810/recent-trends-in-sorption-based-sample-preparation-and-liquid-chromatography-techniques-for-food-analysis
#14
Edvaldo V Soares Maciel, Ana Lúcia de Toffoli, Fernando Mauro Lanças
The accelerated rising of the world's population increased the consumption of food, thus demanding more rigors in the control of residue and contaminants in food-based products marketed for human consumption. In view of the complexity of most food matrices, including fruits, vegetables, different types of meat, beverages, among others, a sample preparation step is important to provide more reliable results when combined with high performance liquid chromatography separations. An adequate sample preparation step before the chromatographic analysis is mandatory in obtaining higher precision and accuracy in order to improve the extraction of the target analytes, one of the priorities in analytical chemistry...
April 20, 2018: Electrophoresis
https://www.readbyqxmd.com/read/29676579/antibacterial-indole-alkaloids-with-complex-heterocycles-from-voacanga-africana
#15
Cai-Feng Ding, Hong-Xia Ma, Jing Yang, Xu-Jie Qin, Guy S S Njateng, Hao-Fei Yu, Xin Wei, Ya-Ping Liu, Wan-Yi Huang, Zi-Feng Yang, Xin-Hua Wang, Xiao-Dong Luo
Voacafricines A and B, two unique monoterpenoid indole alkaloids each bearing five fused heterocycles, were obtained from the fruits of Voacanga africana. Their structures were elucidated by extensive spectroscopic methods and computational studies. A plausible biogenetic pathway was proposed from a common precursor, 19- epi-voacristine. Both compounds exhibited potent activity against Staphylococcus aureus and Salmonella typhi, and their activities were superior to those of the well-known antibacterial drugs berberine and fibrauretine...
April 20, 2018: Organic Letters
https://www.readbyqxmd.com/read/29676249/preharvest-farming-practices-impacting-fresh-produce-safety
#16
Eduardo Gutierrez-Rodriguez, Achyut Adhikari
Advancements in agriculture and food processing techniques have been instrumental in the development of modern human societies. Vast improvements in agronomic practices, handling, and processing have allowed us to produce and preserve mass quantities of food. Yet despite all these innovations and potentially as a consequence of these mass production practices, more and more outbreaks of human pathogens linked to raw and processed foods are identified every year. It is evident that our increased capacity for microbial detection has contributed to the greater number of outbreaks detected...
April 2018: Microbiology Spectrum
https://www.readbyqxmd.com/read/29676138/-clinical-experience-and-academic-thoughts-of-professor-liu-feng-bin-on-case-series-of-gastroesophageal-reflux-disease-based-on-data-mining
#17
Zheng-Kun Hou, Ji-Ping Li, Zhuo-Qun Chen, Feng-Bin Liu
To analyze and summarize Professor LIU Feng-bin's clinical experience and academic thoughts on gastroesophageal reflux disease (GERD), the study group adopted the retrospective study for case series and expert interview, extracted the retrospective data, including the herbs, diseases, syndrome type, medical expense and quantity of herbs of GERD patients attended the First Affiliated Hospital of Guangzhou University of Chinese Medicine. Statistical description and binary Logistic regression were used for the identification and modification of syndrome type and initial core herbs...
March 2018: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29676115/-survival-state-and-fruiting-characteristics-of-endangered-medicinal-plant-sinopodophyllum-hexandrum-plant-in-tibet-plateau
#18
Qi-Qiang Guo, Chao Gao, Hui-E Li, Yan-Hui Ye, Yan-Ying Han
This study was carried out by the methods of typical plots investigation and laboratory test aiming at analyzing the survival state and fruiting characteristics of three Sinopodophyllum hexandrum populations in different environmental habitats. Meanwhile, it could provide scientific basis for enhancing wild population quantity recovery. The results showed that more population quantity grow in the habitats of large-area gap (Population A) and bushes (Population C) with a majority of the young individuals, while the minor-area gap (Population B) was the opposite...
March 2018: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29676017/valorization-of-postharvest-discard-of-sweet-cherry-for-the-development-of-dehydrated-fruit-ingredients-compositional-physical-and-mechanical-properties
#19
Lorena Franceschinis, Paula Sette, Daniela Salvatori, Carolina Schebor
BACKGROUND: Sweet cherries are an excellent source of phenolic compounds, which may contribute to a healthy diet. The objective of this work was to generate dehydrated ingredients from postharvest discard of sweet cherries. RESULTS: Four dried ingredients were obtained from discard of fresh sweet cherry (Lapins var.), through the application of an osmotic dehydration pretreatment and freeze- or air-drying. The ingredients showed an important phenolic contribution (2...
April 20, 2018: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/29675960/translating-value-based-health-care-an-experiment-into-healthcare-governance-and-dialogical-accountability
#20
Morten Bonde, Claus Bossen, Peter Danholt
This article analyses an experiment into healthcare governance in Denmark inspired by principles of value-based health care and intended to re-orient the focus of healthcare governance from 'productivity' to 'value for the patient'. The region in charge of the experiment exempted nine hospital departments from activity-based financing and accountability based on diagnosis-related groups, which allegedly incentivised hospitals in 'perverse' and counterproductive ways. Instead, the departments were to develop new indicators from their local practices to support and account for quality and value for the patient...
April 19, 2018: Sociology of Health & Illness
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