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Intraperitoneal bupivacaine

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https://www.readbyqxmd.com/read/27761040/a-comparison-of-intraperitoneal-bupivacaine-tramadol-with-bupivacaine-magnesium-sulphate-for-pain-relief-after-laparoscopic-cholecystectomy-a-prospective-randomised-study
#1
Anurag Yadava, Sunil K Rajput, Sarika Katiyar, Rajnish K Jain
BACKGROUND AND AIMS: In laparoscopic surgeries, intraperitoneal instillation of local anaesthetics and opioids is gaining popularity, for better pain relief. This study compared the quality and duration of post-operative analgesia using intraperitoneal tramadol plus bupivacaine (TB) or magnesium plus bupivacaine (MB). METHODS: In this study, 186 patients undergoing laparoscopic cholecystectomy were randomly divided into two groups: group TB received intraperitoneal tramadol with bupivacaine and group MB received intraperitoneal magnesium sulphate (MgSO4) with bupivacaine...
October 2016: Indian Journal of Anaesthesia
https://www.readbyqxmd.com/read/27678271/can-intraperitoneal-bupivacaine-decreases-pain-in-patients-undergoing-laparoscopic-live-donor-nephrectomy-a-randomized-control-trial
#2
Ankush Jairath, Arvind Ganpule, Shinu Gupta, Shashikant Mishra, Ravindra Sabnis, Mahesh Desai
PURPOSE: To evaluate effect of intraperitoneal bupivacaine on postoperative pain in patients undergoing laparoscopic live donor nephrectomy. METHODS: Hundred patients undergoing laparoscopic live donor nephrectomy were included in the study and were divided randomly into two groups based on computer-generated randomization chart of fifty each. Patients were made familiar with VAS chart preoperatively. Group A received 20 mL of 0.5 % bupivacaine, while group B patients received 20 mL of 0...
September 27, 2016: World Journal of Urology
https://www.readbyqxmd.com/read/27537538/intraperitoneal-local-anesthetic-for-laparoscopic-appendectomy-in-children-a-randomized-controlled-trial
#3
James K Hamill, Andrew Liley, Andrew G Hill
OBJECTIVE: The aim of this study was to investigate the efficacy of intraperitoneal local anesthetic (IPLA) on pain after acute laparoscopic appendectomy in children. SUMMARY OF BACKGROUND: IPLA reduces pain in adult elective surgery. It has not been well studied in acute peritoneal inflammatory conditions. We hypothesized that IPLA would improve recovery in pediatric acute laparoscopic appendectomy. METHODS: This randomized controlled trial in acute laparoscopic appendectomy recruited children aged 8 to 14 years to receive 20 mL 0...
August 17, 2016: Annals of Surgery
https://www.readbyqxmd.com/read/27281728/giving-priority-to-lipid-administration-can-reduce-lung-injury-caused-by-epinephrine-in-bupivacaine-induced-cardiac-depression
#4
Mengxu Luo, Xia Yun, Chaoxing Chen, Nana Bao, Xiaona Feng, Linmin Pan, Zhousheng Jin, Cong Wu, Xianqin Wang, Thomas J Papadimos, Xuzhong Xu
BACKGROUND AND OBJECTIVES: Epinephrine is usually administered in concert with a lipid emulsion during local anesthetic toxicity. However, the timing and role of epinephrine administration in combination with a lipid emulsion remain unclear. Specifically, the temporal association of epinephrine and lipid emulsion administration with related changes in pulmonary vascular pressures that may lead to pulmonary edema and hemorrhage needs to be determined. METHODS: This study consisted of 2 parts, experiments A and B...
July 2016: Regional Anesthesia and Pain Medicine
https://www.readbyqxmd.com/read/27279399/comparative-study-of-postoperative-analgesic-effect-of-intraperitoneal-instillation-of-dexmedetomidine-with-bupivacaine-and-bupivacaine-alone-after-laparoscopic-surgery
#5
Vrinda P Oza, Vandana Parmar, Jigisha Badheka, Dharam S Nanavati, Pradip Taur, Ajay M Rajyaguru
AIMS: This prospective double-blinded study was designed with the aim of comparing the analgesic effect of intraperitoneal instillation of dexmedetomidine with bupivacaine with that with bupivacaine alone in patients undergoing laparoscopic surgeries. MATERIALS AND METHODS: A total of 100 patients of either sex undergoing elective laparoscopic surgery were randomly divided into two groups containing 50 patients in each group. Group B received intraperitoneal instillation with 50 mL of bupivacaine 0...
July 2016: Journal of Minimal Access Surgery
https://www.readbyqxmd.com/read/27275060/intraperitoneal-pre-insufflation-of-0-125-bupivaciane-with-tramadol-for-postoperative-pain-relief-following-laparoscopic-cholecystectomy
#6
Aslam Jamal, Hammad Usmani, Mohd Mozaffar Khan, Amjad Ali Rizvi, Mohd Masood Hussain Siddiqi, Mohammad Aslam
BACKGROUND AND AIMS: Laparoscopic cholecystectomy is associated with a fairly high incidence of postoperative discomfort which is more of visceral origin than somatic. Studies have concluded that the instillation of local anesthetic with opioid around gall bladder bed provides more effective analgesia than either local anesthetic or opioid alone. MATERIAL AND METHODS: The study included 90 American Society of Anesthesiologists I-II patients of age 16-65 years scheduled for laparoscopic cholecystectomy under general anesthesia...
April 2016: Journal of Anaesthesiology, Clinical Pharmacology
https://www.readbyqxmd.com/read/27251828/comparative-study-of-postoperative-analgesic-effect-of-intraperitoneal-instillation-of-dexmedetomidine-with-bupivacaine-and-bupivacaine-alone-after-laparoscopic-surgery
#7
Vrinda P Oza, Vandana Parmar, Jigisha Badheka, Dharam S Nanavati, Pradip Taur, Ajay M Rajyaguru
AIMS: This prospective double-blinded study was designed with the aim of comparing the analgesic effect of intraperitoneal instillation of dexmedetomidine with bupivacaine with that with bupivacaine alone in patients undergoing laparoscopic surgeries. MATERIALS AND METHODS: A total of 100 patients of either sex undergoing elective laparoscopic surgery were randomly divided into two groups containing 50 patients in each group. Group B received intraperitoneal instillation with 50 mL of bupivacaine 0...
April 28, 2016: Journal of Minimal Access Surgery
https://www.readbyqxmd.com/read/27227503/pharmacokinetics-of-bupivacaine-after-intraperitoneal-administration-to-cats-undergoing-ovariohysterectomy
#8
Javier Benito, Beatriz P Monteiro, Francis Beaudry, Anne-Marie Lavoie, B Duncan X Lascelles, Paulo V Steagall
OBJECTIVE To evaluate pharmacokinetics of bupivacaine after IP administration to cats undergoing ovariohysterectomy. ANIMALS 8 healthy cats. PROCEDURES Anesthesia was induced with propofol and maintained with isoflurane. Buprenorphine (0.02 mg/kg, IV) and meloxicam (0.2 mg/kg, SC) were administered. A 20-gauge catheter was inserted into a jugular vein for blood sample collection. A ventral midline incision was made, and a solution of 0.5% bupivacaine (2 mg/kg) diluted with an equal volume of saline (0.9% NaCl) solution (final concentration, 0...
June 2016: American Journal of Veterinary Research
https://www.readbyqxmd.com/read/26957685/a-comparative-study-on-postoperative-pain-relief-in-laparoscopic-cholecystectomy-intraperitoneal-bupivacaine-versus-combination-of-bupivacaine-and-buprenorphine
#9
Sandeep Khurana, Kamakshi Garg, Anju Grewal, Tej K Kaul, Abhishek Bose
CONTEXT: To assess the analgesic efficacy of the combination of bupivacaine and buprenorphine in alleviating postoperative pain following laparoscopic cholecystectomy. AIMS: Laparoscopic cholecystectomy is comparatively advantageous as it offers less pain in the postoperative period and requires a shorter hospital stay. There are only a few studies performed to evaluate the analgesic efficacy of intraperitoneal instillation of buprenorphine and bupivacaine during laparoscopic cholecystectomy...
January 2016: Anesthesia, Essays and Researches
https://www.readbyqxmd.com/read/26870925/intraperitoneal-bupivacaine-with-or-without-incisional-bupivacaine-for-postoperative-analgesia-in-dogs-undergoing-ovariohysterectomy
#10
Karin S Kalchofner Guerrero, Ivo Campagna, Rodolfo Bruhl-Day, Cecilia Hegamin-Younger, Tomas G Guerrero
OBJECTIVE: Intraperitoneal (IP) bupivacaine provides postoperative analgesia in dogs undergoing ovariohysterectomy (OHE) alone or in combination with incisional (INC) bupivacaine. This study investigated whether the combination of INC and IP bupivacaine is superior to IP bupivacaine alone. STUDY DESIGN: Prospective, randomized, blinded clinical study. ANIMALS: Thirty-nine privately owned dogs undergoing OHE, aged 25 ± 23 months and weighing 11...
September 2016: Veterinary Anaesthesia and Analgesia
https://www.readbyqxmd.com/read/26467541/analgesic-efficacy-of-intraperitoneal-administration-of-bupivacaine-in-cats
#11
Javier Benito, Beatriz Monteiro, Anne-Marie Lavoie, Guy Beauchamp, B Duncan X Lascelles, Paulo V Steagall
OBJECTIVES: The aim of this study was to evaluate the analgesic efficacy of intraperitoneal (IP) bupivacaine in cats undergoing ovariohysterectomy. METHODS: Forty-five cats were included in a randomized, prospective, blinded study after owners' written consent was obtained. The anesthetic protocol included acepromazine-buprenorphine-propofol-isoflurane. A ventral midline incision was made and cats (n = 15/group) were administered either IP saline 0.9% (negative and positive control groups; NG and PG, respectively) or IP bupivacaine (2 mg/kg; bupivacaine group; BG)...
October 14, 2015: Journal of Feline Medicine and Surgery
https://www.readbyqxmd.com/read/26216095/effect-of-intraperitoneal-bupivacaine-on-postoperative-pain-in-the-gynecologic-oncology-patient
#12
Colleen Rivard, Rachel Isaksson Vogel, Deanna Teoh
STUDY OBJECTIVE: To evaluate if the administration of intraperitoneal bupivacaine decreased postoperative pain in patients undergoing minimally invasive gynecologic and gynecologic cancer surgery. DESIGN: Retrospective cohort study (Canadian Task Force classification II-3). SETTING: University-based gynecologic oncology practice operating at a tertiary medical center. PATIENTS: All patients on the gynecologic oncology service undergoing minimally invasive surgery between September 2011 and June 2013...
November 2015: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/26161328/intraperitoneal-bupivacaine-meperidine-infiltration-versus-intravenous-paracetamol-a-comparison-of-analgesic-efficacy-in-post-gynecologic-diagnostic-laparoscopic-pain
#13
Sousan Rasooli, Farnaz Moslemi, Samad E J Golzari
BACKGROUND: Pain following laparoscopy could be due to different causes requiring effective postoperative analgesia. OBJECTIVES: In the present study, we evaluated the combined effect of intraperitoneal infiltration of bupivacaine-meperidine versus intravenous infusion of paracetamol on pain relief after diagnostic gynecologic laparoscopy. PATIENTS AND METHODS: In this prospective study, 90 female subjects with ASA class I or II scheduled for gynecologic diagnostic laparoscopy were studied in two groups; group B + M received intraperitoneal infiltration of 40 mL bupivacaine 0...
June 2015: Anesthesiology and Pain Medicine
https://www.readbyqxmd.com/read/26049779/the-local-and-systemic-actions-of-duloxetine-in-allodynia-and-hyperalgesia-using-a-rat-skin-incision-pain-model
#14
Chi-Fei Wang, Gabriella Russell, Gary R Strichartz, Ging-Kuo Wang
BACKGROUND: Duloxetine is an antidepressant effective for major depressive disorder and also the alleviation of pain for patients with diabetic peripheral neuropathy, chronic musculoskeletal pain, and fibromyalgia. How duloxetine works in pain relief remains unknown. In this study, we address whether duloxetine could act as an analgesic via systemic and local applications. METHODS: Efficacies of bupivacaine and duloxetine applied subcutaneously at the incision site against acute postoperative pain were compared after rat skin incision...
August 2015: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/26018054/effectiveness-of-local-anesthetics-in-laparoscopic-cholecystectomy-a-randomized-clinical-trial
#15
RANDOMIZED CONTROLLED TRIAL
Marcelo M Souto, Eloisa Radaelli, Andiara E Giordani, Analuíza Savaris, Guilherme F Bassols
BACKGROUND: Laparoscopic cholecystectomy is the gold standard for gallstone disease. Postoperative pain still is considerable and may prevent early discharge. METHODS: A randomized controlled blind clinical trial was designed for all patients undergoing laparoscopic cholecystectomy. The groups were control (group A), preincisional trocar wound infiltration with bupivacaine (group B), and preincisional trocar wound infiltration and intraperitoneal instillation of bupivacaine over the gallbladder and liver surface before starting the dissection (group C)...
August 2015: Surgical Laparoscopy, Endoscopy & Percutaneous Techniques
https://www.readbyqxmd.com/read/25937650/intraperitoneal-bupivacaine-alone-or-with-dexmedetomidine-or-tramadol-for-post-operative-analgesia-following-laparoscopic-cholecystectomy-a-comparative-evaluation
#16
Usha Shukla, T Prabhakar, Kiran Malhotra, Dheeraj Srivastava, Kriti Malhotra
BACKGROUND AND AIMS: Intraperitoneal instillation of local anaesthetics has been shown to minimise post-operative pain after laparoscopic surgeries. We compared the antinociceptive effects of intraperitoneal dexmedetomidine or tramadol combined with bupivacaine to intraperitoneal bupivacaine alone in patients undergoing laparoscopic cholecystectomy. METHODS: A total of 120 patients were included in this prospective, double-blind, randomised study. Patients were randomly divided into three equal sized (n = 40) study groups...
April 2015: Indian Journal of Anaesthesia
https://www.readbyqxmd.com/read/25899736/efficacy-of-a-laparoscopically-delivered-transversus-abdominis-plane-block-technique-during-elective-laparoscopic-cholecystectomy-a-prospective-double-blind-randomized-trial
#17
RANDOMIZED CONTROLLED TRIAL
Ghassan Elamin, Peadar S Waters, Hytham Hamid, Hannah M O'Keeffe, Ronan M Waldron, Michelle Duggan, Waqar Khan, Michael Kevin Barry, Iqbal Z Khan
BACKGROUND: The management of postoperative pain is paramount to facilitate the delivery of day case surgical programs. In recent years, the complexity of procedures carried out has increased to include laparoscopic cholecystectomy. The aim of this study was to evaluate the impact of laparoscopic-assisted 4-quadrant transversus abdominis plane (TAP) block vs periportal local anesthetic wound infiltration in managing postoperative pain. STUDY DESIGN: A prospective, randomized, double-blinded trial was conducted with patients undergoing elective laparoscopic cholecystectomy...
August 2015: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/25832632/protective-effects-of-bupivacaine-against-kainic-acid-induced-seizure-and-neuronal-cell-death-in-the-rat-hippocampus
#18
Kuan Ming Chiu, Chia Chan Wu, Ming Jiuh Wang, Ming Yi Lee, Su Jane Wang
The excessive release of glutamate is a critical element in the neuropathology of epilepsy, and bupivacaine, a local anesthetic agent, has been shown to inhibit the release of glutamate in rat cerebrocortical nerve terminals. This study investigated whether bupivacaine produces antiseizure and antiexcitotoxic effects using a kainic acid (KA) rat model, an animal model used for temporal lobe epilepsy, and excitotoxic neurodegeneration experiments. The results showed that administering bupivacaine (0.4 mg/kg or 2 mg/kg) intraperitoneally to rats 30 min before intraperitoneal injection of KA (15 mg/kg) increased seizure latency and reduced the seizure score...
2015: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/25585502/efficacy-and-safety-of-intraperitoneal-dexmedetomidine-with-bupivacaine-in-laparoscopic-colorectal-cancer-surgery-a-randomized-trial
#19
RANDOMIZED CONTROLLED TRIAL
Khaled Mohamed Fares, Sahar Abd-Elbaky Mohamed, Ahmad Mohammad Abd El-Rahman, Ashraf Amin Mohamed, Anwar Tawfik Amin
OBJECTIVE: Our objective is to investigate the efficacy and safety of intraperitoneal dexmedetomidine (Dex) combined with bupivacaine in patients undergoing laparoscopic colorectal cancer surgery. DESIGN: Randomized double-blind study. SETTING: Academic medical center. PATIENTS AND METHODS: Forty-five patients scheduled for laparoscopic colorectal cancer surgery were randomly assigned for intraperitoneal administration of 50 mL saline (control group; GI, n = 15), 50 mL bupivacaine 0...
June 2015: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/25571981/efficacy-of-surgical-transversus-abdominis-plane-block-for-postoperative-pain-relief-following-abdominal-surgery-in-pediatric-patients
#20
RANDOMIZED CONTROLLED TRIAL
Saowaphak Lapmahapaisan, Niramol Tantemsapya, Naiyana Aroonpruksakul, Wiriya Maisat, Suwannee Suraseranivongse
BACKGROUND: Transversus abdominis plane (TAP) block is a promising effective method for postoperative pain control after major abdominal surgery. Using a landmark technique, it is easily performed, but its popularity has decreased because of less efficacy due to inaccurate injection and the potential for intraperitoneal organ damage. Ultrasound-guided TAP block provides better results and less complications, but it requires experienced operators. Surgically administered TAP (sTAP) block is a simple technique and may cause less complications...
June 2015: Paediatric Anaesthesia
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