keyword
https://read.qxmd.com/read/38537011/effect-of-zro2-paste-surface-treatments-and-storage-on-weibull-characteristics-and-resin-bond-strength-to-zirconia
#1
JOURNAL ARTICLE
Anne Heloyse Teixeira Crispim, Sarah Emille Gomes da Silva, Fernanda Gurgel de Gois Moreira, Bianca Cristina Dantas da Silva, Amanda Maria de Oliveira Dal Piva, Liliana Gressler May, Natália de Freitas Daudt, Rodrigo Othávio Assunção Souza
The objective is to evaluate the effect of different surface treatments and storage on the shear strength of ultratranslucent zirconia. 36 blocks of ultra-translucent zirconia were fabricated (7x7x2mm) and sintered. Then, divided into 12 groups according to the "surface treatment" (C -Primer; Al -Sandblasting with Al2O3 + Primer; Si -Silicate + Primer; Gl -Glaze + HF + Primer; Z -Zirlink; Zp -Zirlink + Primer) and "storage" factors (ST-with 150 days/37º and without). After surface treatment, five cylinders (Ø=2mm; h=2...
2024: Brazilian Dental Journal
https://read.qxmd.com/read/38536952/familial-recurrence-of-incontinentia-pigmenti-due-to-de-novo-pathogenic-variants-in-the-ikbkg-gene
#2
Julie Steffann, Judite De Oliveira Santos, Anne-Laure Zelbin, Smail Hadj-Rabia, Fabienne Charbit-Henrion, Florence Petit
Incontinentia pigmenti (IP, Bloch-Sulzberger syndrome) is a multisystem disorder which associates specific skin lesions that evolves in four stages, and occasionally, central nervous system, eye, hair, and teeth involvement. Familial (35%) and sporadic (65%) cases are caused by pathogenic variants in the IKBKG gene. Here we report an unusual family, where, in two half-sisters affected by typical IP, molecular genetic analysis identified a likely pathogenic non-sense variant in the IKBKG gene of one of the sisters, the other being not a carrier...
March 27, 2024: American Journal of Medical Genetics. Part A
https://read.qxmd.com/read/38536900/optimized-bags-of-artificial-neural-networks-can-predict-the-viability-of-organisms-exposed-to-nanoparticles
#3
JOURNAL ARTICLE
Ravithree D Senanayake, Clyde A Daly, Rigoberto Hernandez
Prediction of organismal viability upon exposure to a nanoparticle in varying environments─as fully specified at the molecular scale─has emerged as a useful figure of merit in the design of engineered nanoparticles. We build on our earlier finding that a bag of artificial neural networks (ANNs) can provide such a prediction when such machines are trained with a relatively small data set (with ca. 200 examples). Therein, viabilities were predicted by consensus using the weighted means of the predictions from the bags...
March 27, 2024: Journal of Physical Chemistry. A
https://read.qxmd.com/read/38536883/maternal-and-umbilical-cord-blood-lead-levels-in-selected-informal-settlements-in-nairobi-kenya-a-cross-sectional-study
#4
JOURNAL ARTICLE
Edith A Lumumba, Anne M Riederer, John O Onyatta, Sarah Benki-Nugent, Catherine J Karr, Faridah H Were
No abstract text is available yet for this article.
March 2024: Environmental Health Perspectives
https://read.qxmd.com/read/38536875/investigating-hill-sheep-farmers-and-crofters-experiences-of-blackloss-in-the-highlands-and-islands-of-scotland
#5
JOURNAL ARTICLE
Fiona McAuliffe, Ann McLaren, Neil Sargison, Franz Brülisauer, Andrew Kent, Davy McCracken
Hill sheep farming is an important component of Scottish agriculture and comprises a significant land use in much of the Highlands and Islands. However it faces significant challenges due to the natural constraints of the landscape. Hill sheep farming uses hardy traditional breeds, such as the Scottish blackface and North Country Cheviot to graze extensive areas, where the sheep are not housed and tend to lamb on the open hill. Flocks are gathered several times a year for stock checks, husbandry, and health treatments...
2024: PloS One
https://read.qxmd.com/read/38536816/iqgap1-and-nwasp-promote-human-cancer-cell-dissemination-and-metastasis-by-regulating-%C3%AE-1-integrin-via-fak-and-mrtf-srf
#6
JOURNAL ARTICLE
Camilla Cerutti, Serena Lucotti, Sofia T Menendez, Nicolas Reymond, Ritu Garg, Ignacio A Romero, Ruth Muschel, Anne J Ridley
Attachment of circulating tumor cells to the endothelial cells (ECs) lining blood vessels is a critical step in cancer metastatic colonization, which leads to metastatic outgrowth. Breast and prostate cancers are common malignancies in women and men, respectively. Here, we observe that β1-integrin is required for human prostate and breast cancer cell adhesion to ECs under shear-stress conditions in vitro and to lung blood vessel ECs in vivo. We identify IQGAP1 and neural Wiskott-Aldrich syndrome protein (NWASP) as regulators of β1-integrin transcription and protein expression in prostate and breast cancer cells...
March 26, 2024: Cell Reports
https://read.qxmd.com/read/38536806/lower-autonomic-arousal-as-a-risk-factor-for-criminal-offending-and-unintentional-injuries-among-female-conscripts
#7
JOURNAL ARTICLE
Sofi Oskarsson, Anneli Andersson, Bridget M Bertoldi, Antti Latvala, Ralf Kuja-Halkola, Brittany Evans, Adrian Raine, Christopher J Patrick, Henrik Larsson, Catherine Tuvblad
BACKGROUND: Lower autonomic arousal is a well-known correlate of criminal offending and other risk-taking behaviors in men, but few studies have investigated this association in women. AIM: To test associations between autonomic arousal and criminal offending as well as unintentional injuries among female conscripts. METHODS: All women born 1958-1994 in Sweden who participated in voluntary military conscription (n = 12,499) were identified by linking Swedish population-based registers...
2024: PloS One
https://read.qxmd.com/read/38536724/in-silico-methods-for-immunogenicity-risk-assessment-and-human-homology-screening-for-therapeutic-antibodies
#8
JOURNAL ARTICLE
Aimee E Mattei, Andres H Gutierrez, Soorya Seshadri, Jacob Tivin, Matt Ardito, Amy S Rosenberg, William D Martin, Anne S De Groot
In silico immunogenicity risk assessment has been an important step in the development path for many biologic therapeutics, including monoclonal antibodies. Even if the source of a given biologic is 'fully human', T cell epitopes that are contained in the sequences of the biologic may activate the immune system, enabling the development of anti-drug antibodies that can reduce drug efficacy and may contribute to adverse events. Computational tools that identify T cell epitopes from primary amino acid sequences have been used to assess the immunogenic potential of therapeutic candidates for several decades...
2024: MAbs
https://read.qxmd.com/read/38536438/-parental-strain-inattention-hyperactivity-symptoms-and-parent-reported-adhd-in-children-and-adolescents-results-of-the-kiggs-study
#9
JOURNAL ARTICLE
Laura Neuperdt, Ann-Kristin Beyer, Stephan Junker, Elvira Mauz, Heike Hölling, Robert Schlack
BACKGROUND: A child's attention deficit hyperactivity disorder (ADHD) is associated with strain for the parents. In turn, psychosocial parental strain is associated with higher probabilities for the occurrence of inattention/hyperactivity symptoms (IHS) in their children. The aim of this paper is to assess the association between parental strain, IHS, and a parent-reported ADHD diagnosis of the children. METHODOLOGY: Based on data from n = 4596 participants of the KiGGS cohort (wave 2: 2014-2017), the type and extent of parental strain was set in relation to IHS and an ADHD diagnosis of the child in cross-sectional analysis...
March 27, 2024: Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz
https://read.qxmd.com/read/38536215/infant-mortality-by-selected-maternal-characteristics-and-race-and-hispanic-origin-in-the-united-states-2019-2021
#10
JOURNAL ARTICLE
Danielle M Ely, Anne K Driscoll
Objectives- This report presents infant mortality rates for selected maternal characteristics (prepregnancy body mass index, cigarette smoking during pregnancy, receipt of Special Supplemental Nutrition Program for Women, Infants, and Children (WIC) benefits during pregnancy, timing of prenatal care, and source of payment for delivery) for the five largest maternal race and Hispanic-origin groups in the United States for combined years 2019-2021. Methods-Descriptive tabulations based on data from the linked birth/infant death files for 2019-2021 are presented...
March 2024: National Vital Statistics Reports
https://read.qxmd.com/read/38536177/sitting-time-reduction-and-blood-pressure-in-older-adults-a-randomized-clinical-trial
#11
JOURNAL ARTICLE
Dori E Rosenberg, Weiwei Zhu, Mikael Anne Greenwood-Hickman, Andrea J Cook, Stefani Florez Acevedo, Jennifer B McClure, David E Arterburn, Julie Cooper, Neville Owen, David Dunstan, Stephen R Perry, Laura Yarborough, Kayne D Mettert, Beverly B Green
IMPORTANCE: Practical health promotion strategies for improving cardiometabolic health in older adults are needed. OBJECTIVE: To examine the efficacy of a sedentary behavior reduction intervention for reducing sitting time and improving blood pressure in older adults. DESIGN, SETTING, AND PARTICIPANTS: This parallel-group randomized clinical trial was conducted in adults aged 60 to 89 years with high sitting time and body mass index of 30 to 50 from January 1, 2019, to November 31, 2022, at a health care system in Washington State...
March 4, 2024: JAMA Network Open
https://read.qxmd.com/read/38536098/-escherichia-coli-isolated-from-bovine-sources-encoding-the-fosfomycin-resistance-gene-fosa7-5
#12
JOURNAL ARTICLE
Bradd J Haley, Seon Woo Kim, Jo Ann Van Kessel
Dairy animals are reservoirs of antimicrobial-resistant Escherichia coli that are frequently resistant to tetracycline, aminoglycoside, β-lactam, sulfonamide, and macrolide-lincosamide-streptogramin B antibiotics. However, resistance to other classes of antimicrobials is less frequently observed, and resistance to fosfomycin is rarely observed in E. coli . In this study, we describe the genomic characteristics of E. coli encoding fosA7.5 that have been recovered from bovine sources in the United States...
March 27, 2024: Foodborne Pathogens and Disease
https://read.qxmd.com/read/38536036/the-gtpase-activating-protein-gyp7-regulates-rab7-ypt7-activity-on-late-endosomes
#13
JOURNAL ARTICLE
Nadia Füllbrunn, Raffaele Nicastro, Muriel Mari, Janice Griffith, Eric Herrmann, René Rasche, Ann-Christin Borchers, Kathrin Auffarth, Daniel Kümmel, Fulvio Reggiori, Claudio De Virgilio, Lars Langemeyer, Christian Ungermann
Organelles of the endomembrane system contain Rab GTPases as identity markers. Their localization is determined by guanine nucleotide exchange factors (GEFs) and GTPase activating proteins (GAPs). It remains largely unclear how these regulators are specifically targeted to organelles and how their activity is regulated. Here, we focus on the GAP Gyp7, which acts on the Rab7-like Ypt7 protein in yeast, and surprisingly observe the protein exclusively in puncta proximal to the vacuole. Mistargeting of Gyp7 to the vacuole strongly affects vacuole morphology, suggesting that endosomal localization is needed for function...
June 3, 2024: Journal of Cell Biology
https://read.qxmd.com/read/38535835/use-of-monoglycerides-and-diglycerides-to-mitigate-poultry-production-losses-a-review
#14
REVIEW
Stacie R Appleton, Anne Ballou, Kevin L Watkins
Consumer preference dictates not only what food is consumed but also how that food is produced. Ingredients in livestock feed that are not antibiotics, not genetically modified, and not of animal origin but that are nutrient-like tend to be more acceptable to consumers, retailers, and producers. Mono- and diglycerides (MDG) fit these criteria, are commonly used in food, and are generally recognized as safe. But beyond being emulsifiers and a source of energy, MDG are also known to have antimicrobial, immune, and microbiome modulation and angiogenic activity...
February 27, 2024: Veterinary Sciences
https://read.qxmd.com/read/38535725/patient-reported-association-between-covid-19-infection-or-vaccination-and-onset-of-allergic-contact-dermatitis
#15
JOURNAL ARTICLE
Nicholas Battis, Samuel F Ekstein, Eric Eugene Paul Cosky, Anne B Neeley
<u> Background: </u> Over the course of the COVID-19 pandemic, our clinic has encountered numerous patients who report that either COVID-19 vaccination or infection was the precipitating event for their development of allergic contact dermatitis (ACD). Up to this time, there is no formal investigation regarding COVID-19 vaccination or infection causing ACD. However, there have been several registry-based case series of associated dermatoses after COVID-19 infection or vaccination. <u> Objective: </u> This study aimed to describe patient-reported associations between COVID-19 infection or vaccination and onset of ACD...
March 27, 2024: Dermatitis
https://read.qxmd.com/read/38535565/wildlife-as-food-and-medicine-in-brazil-a-neglected-zoonotic-risk
#16
JOURNAL ARTICLE
Caio Graco Zeppelini, Ianei de Oliveira Carneiro, Poliana Mascarenhas de Abreu, Ann Katelynn Linder, Romulo Romeu Nóbrega Alves, Federico Costa
The practice of consuming wild fauna in Brazil is both culturally and socioeconomically questionable. Wild animals and their byproducts are sought for nutritional, medicinal, and/or supernatural reasons, with some taxa (e.g., songbirds) being kept as pets. This practice is concentrated in traditional and rural communities, as well as the rural exodus populations in large urban centers, maintained both by cultural preferences and for their role in food safety in part of the rural exodus community. A total of 564 taxa are known to be sold in wet markets in Brazil, with birds, fish, and mammals being the most commonly listed...
March 2, 2024: Pathogens
https://read.qxmd.com/read/38535296/vertical-metabolome-transfer-from-mother-to-child-an-explainable-machine-learning-method-for-detecting-metabolomic-heritability
#17
JOURNAL ARTICLE
Mario Lovrić, David Horner, Liang Chen, Nicklas Brustad, Ann-Marie Malby Schoos, Jessica Lasky-Su, Bo Chawes, Morten Arendt Rasmussen
Vertical transmission of metabolic constituents from mother to child contributes to the manifestation of disease phenotypes in early life. This study probes the vertical transmission of metabolites from mothers to offspring by utilizing machine learning techniques to differentiate between true mother-child dyads and randomly paired non-dyads. Employing random forests (RF), light gradient boosting machine (LGBM), and logistic regression (Elasticnet) models, we analyzed metabolite concentration discrepancies in mother-child pairs, with maternal plasma sampled at 24 weeks of gestation and children's plasma at 6 months...
February 24, 2024: Metabolites
https://read.qxmd.com/read/38535152/analyzing-data-modalities-for-cattle-weight-estimation-using-deep-learning-models
#18
JOURNAL ARTICLE
Hina Afridi, Mohib Ullah, Øyvind Nordbø, Solvei Cottis Hoff, Siri Furre, Anne Guro Larsgard, Faouzi Alaya Cheikh
We investigate the impact of different data modalities for cattle weight estimation. For this purpose, we collect and present our own cattle dataset representing the data modalities: RGB, depth, combined RGB and depth, segmentation, and combined segmentation and depth information. We explore a recent vision-transformer-based zero-shot model proposed by Meta AI Research for producing the segmentation data modality and for extracting the cattle-only region from the images. For experimental analysis, we consider three baseline deep learning models...
March 21, 2024: Journal of Imaging
https://read.qxmd.com/read/38535127/expanded-newborn-screening-for-inborn-errors-of-metabolism-in-hong-kong-results-and-outcome-of-a-7-year-journey
#19
JOURNAL ARTICLE
Kiran Moti Belaramani, Toby Chun Hei Chan, Edgar Wai Lok Hau, Matthew Chun Wing Yeung, Anne Mei Kwun Kwok, Ivan Fai Man Lo, Terry Hiu Fung Law, Helen Wu, Sheila Suet Na Wong, Shirley Wai Lam, Gladys Ha Yin Ha, Toby Pui Yee Lau, Tsz Ki Wong, Venus Wai Ching Or, Rosanna Ming Sum Wong, Wong Lap Ming, Jasmine Chi Kwan Chow, Eric Kin Cheong Yau, Antony Fu, Josephine Shuk Ching Chong, Ho Chung Yau, Grace Wing Kit Poon, Kwok Leung Ng, Kwong Tat Chan, Yuen Yu Lam, Joannie Hui, Chloe Miu Mak, Cheuk Wing Fung
Newborn screening (NBS) is an important public health program that aims to identify pre-symptomatic healthy babies that will develop significant disease if left undiagnosed and untreated. The number of conditions being screened globally is expanding rapidly in parallel with advances in technology, diagnosis, and treatment availability for these conditions. In Hong Kong, NBS for inborn errors of metabolism (NBSIEM) began as a pilot program in October 2015 and was implemented to all birthing hospitals within the public healthcare system in phases, with completion in October 2020...
March 11, 2024: International Journal of Neonatal Screening
https://read.qxmd.com/read/38535123/harnessing-next-generation-sequencing-as-a-timely-and-accurate-second-tier-screening-test-for-newborn-screening-of-inborn-errors-of-metabolism
#20
JOURNAL ARTICLE
Toby Chun Hei Chan, Chloe Miu Mak, Matthew Chun Wing Yeung, Eric Chun-Yiu Law, Jana Cheung, Tsz Ki Wong, Vincent Wing-Sang Cheng, Jacky Kwan Ho Lee, Jimmy Chi Lap Wong, Cheuk Wing Fung, Kiran Moti Belaramani, Anne Mei Kwun Kwok, Kwok Yeung Tsang
In this study, we evaluated the implementation of a second-tier genetic screening test using an amplicon-based next-generation sequencing (NGS) panel in our laboratory during the period of 1 September 2021 to 31 August 2022 for the newborn screening (NBS) of six conditions for inborn errors of metabolism: citrullinemia type II (MIM #605814), systemic primary carnitine deficiency (MIM #212140), glutaric acidemia type I (MIM #231670), beta-ketothiolase deficiency (#203750), holocarboxylase synthetase deficiency (MIM #253270) and 3-hydroxy-3-methylglutaryl-CoA lyase deficiency (MIM # 246450)...
March 5, 2024: International Journal of Neonatal Screening
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