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https://www.readbyqxmd.com/read/28738672/physiological-and-physical-responses-to-wearing-compression-garments-during-soccer-matches-and-recovery
#1
Diego Marqués-Jiménez, Julio Calleja-González, Iñaki Arratibel, Anne Delextrat, Fernando Uriarte, Nicolás Terrados
BACKGROUND: There is not enough information on the effects of compression therapy in soccer players during recovery after matches. So the objective of this study was to examine the effect of wearing compression garments during soccer matches and during recovery period on physical responses. METHODS: Eighteen semi-professional soccer players participated in this study. A two-stage crossover design was chosen. Participants acted as controls in one match and were assigned to an experimental group (compression stockings group, full-leg compression group, shorts group) in the other match...
July 24, 2017: Journal of Sports Medicine and Physical Fitness
https://www.readbyqxmd.com/read/28738408/cgas-surveillance-of-micronuclei-links-genome-instability-to-innate-immunity
#2
Karen J Mackenzie, Paula Carroll, Carol-Anne Martin, Olga Murina, Adeline Fluteau, Daniel J Simpson, Nelly Olova, Hannah Sutcliffe, Jacqueline K Rainger, Andrea Leitch, Ruby T Osborn, Ann P Wheeler, Marcin Nowotny, Nick Gilbert, Tamir Chandra, Martin A M Reijns, Andrew P Jackson
DNA is strictly compartmentalized within the nucleus to prevent autoimmunity; despite this, cyclic GMP-AMP synthase (cGAS), a cytosolic sensor of double-stranded DNA, is activated in autoinflammatory disorders and by DNA damage. Precisely how cellular DNA gains access to the cytoplasm remains to be determined. Here, we report that cGAS localizes to micronuclei arising from genome instability in a mouse model of monogenic autoinflammation, after exogenous DNA damage and spontaneously in human cancer cells. Such micronuclei occur after mis-segregation of DNA during cell division and consist of chromatin surrounded by its own nuclear membrane...
July 24, 2017: Nature
https://www.readbyqxmd.com/read/28738402/biodistribution-of-liver-derived-mesenchymal-stem-cells-after-peripheral-injection-in-a-hemophilia-a-patient
#3
Etienne M Sokal, Catherine Anne Lombard, Véronique Roelants, Mustapha Najimi, Sharat Varma, Camillo Sargiacomo, Joachim Ravau, Giuseppe Mazza, François Jamar, Julia Versavau, Vanessa Jacobs, Marc Jacquemin, Stéphane Eeckhoudt, Catherine Lambert, Xavier Stéphenne, Françoise Smets, Cédric Hermans
BACKGROUND: With the exception of liver transplantation, there is no cure for hemophilia, which is currently managed by preemptive replacement therapy. Liver-derived stem cells are in clinical development for inborn and acquired liver diseases and could represent a curative treatment for hemophilia A. The liver is a major factor VIII (FVIII) synthesis site, and mesenchymal stem cells have been shown to control joint bleeding in animal models of hemophilia. Adult-derived human liver stem cells (ADHLSCs) have mesenchymal characteristics and have been shown able to engraft in and repopulate both animal and human livers...
August 2017: Transplantation
https://www.readbyqxmd.com/read/28738342/a-succinct-history-of-sleep-medicine
#4
Leh-Kiong Anne Huon, Christian Guilleminault
Although sleep and sleep disorders have been studied for centuries, it was the development of sophisticated tools to monitor eye movements, brain waves, and muscle tone in the mid-20th century that led to modern sleep research. These tools allowed neuroscientists to distinguish between different "states" or "phases" of sleep, and to relate these findings to sleep disorders. This review chronicles the groundbreaking work of the pioneers in this field, and the impact their findings have had on patients today.
2017: Advances in Oto-rhino-laryngology
https://www.readbyqxmd.com/read/28738331/future-perspectives-in-sleep-medicine
#5
Leh-Kiong Anne Huon, Christian Guilleminault
"Sleep Medicine" is now a specialty in its own right. Currently, there is increasing recognition of the very negative impact sleep disorders have on learning, education, safety, and quality of life. Technological advances will help us to break down diagnoses (e.g., narcolepsy has now been subdivided into types 1 and 2, depending upon the hypocretin levels in the spinal fluid) and to discover relationships to other bodily systems (e.g., type 1 narcolepsy potentially being an autoimmune disorder). The modern lifestyle of many, as characterized by a shortening of sleep periods, shift work, jet lag, and the need to be constantly available, means that advances in sleep medicine may result in a major understanding of more balanced "work-rest lifestyle" modifications...
2017: Advances in Oto-rhino-laryngology
https://www.readbyqxmd.com/read/28738287/perceived-stress-and-poly-tobacco-product-use-across-adolescence-patterns-of-association-and-gender-differences
#6
Adam M Leventhal, Robert Urman, Jessica L Barrington-Trimis, Nicholas I Goldenson, Katia Gallegos, Chih Ping Chou, Kejia Wang, Kiros Berhane, Tess Boley Cruz, Mary Ann Pentz, Jennifer Unger, Rob S McConnell
Perceived stress-an endophenotype indicative of the tendency to appraise stress as frequent, unpredictable and unmanageable-is associated with adolescent cigarette smoking. It is unclear whether this association: (1) extends to alternative tobacco products, like electronic cigarettes and hookah (tobacco water pipe), which are increasingly popular among youth, and (2) differs by gender. In this report, data were drawn from a population-based longitudinal cohort of youth in Southern California. Perceived stress was assessed at baseline (7th or 8th grade; 2010)...
July 14, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/28738258/open-label-multicentre-randomised-phase-ii-study-of-the-epssg-and-the-itcc-evaluating-the-addition-of-bevacizumab-to-chemotherapy-in-childhood-and-adolescent-patients-with-metastatic-soft-tissue-sarcoma-the-bernie-study
#7
Julia C Chisholm, Johannes H M Merks, Michela Casanova, Gianni Bisogno, Daniel Orbach, Jean-Claude Gentet, Anne-Sophie Thomassin-Defachelles, Pascal Chastagner, Stephen Lowis, Milind Ronghe, Kieran McHugh, Rick R van Rijn, Magalie Hilton, Jeanette Bachir, Sabine Fürst-Recktenwald, Birgit Geoerger, Odile Oberlin
PURPOSE: We evaluated the role of bevacizumab as part of the multi-modality treatment of children and adolescents with metastatic rhabdomyosarcoma (RMS) or non-rhabdomyosarcoma soft tissue sarcoma (NRSTS). PATIENTS AND METHODS: Eligible patients aged ≥6 months to <18 years were randomised to receive induction chemotherapy (four cycles of IVADo + five cycles of IVA, ±bevacizumab), surgery and/or radiotherapy, followed by maintenance chemotherapy (12 cycles of low-dose cyclophosphamide + vinorelbine, ±bevacizumab)...
July 21, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28738248/the-reliability-and-validity-of-measurements-of-human-dental-casts-made-by-an-intra-oral-3d-scanner-with-conventional-hand-held-digital-callipers-as-the-comparison-measure
#8
Mithun Rajshekar, Roberta Julian, Anne-Marie Williams, Marc Tennant, Alex Forrest, Laurence J Walsh, Gary Wilson, Leigh Blizzard
AIM: Intra-oral 3D scanning of dentitions has the potential to provide a fast, accurate and non-invasive method of recording dental information. The aim of this study was to assess the reliability of measurements of human dental casts made using a portable intra-oral 3D scanner appropriate for field use. METHOD: Two examiners each measured 84 tooth and 26 arch features of 50 sets of upper and lower human dental casts using digital hand-held callipers, and secondly using the measuring tool provided with the Zfx IntraScan intraoral 3D scanner applied to the virtual dental casts...
July 13, 2017: Forensic Science International
https://www.readbyqxmd.com/read/28738135/development-of-a-shortened-version-of-the-spatial-hearing-questionnaire-shq-s-for-screening-spatial-hearing-ability
#9
Hua Ou, Ann Perreau, Richard Tyler
Purpose: The Spatial Hearing Questionnaire (SHQ) was developed to address how to measure spatial-hearing ability in complex listening situations (Tyler, Perreau, & Ji, 2009). It has been translated and validated into various languages, including Chinese, Dutch, French, and Persian. Although the SHQ contains only 24 items, it could be time-consuming in a busy clinic to administer. The purposes of this study were to develop and validate a shortened version of the SHQ (SHQ-S) and to compare self-perceived spatial-hearing ability across adults with normal hearing (NH), hearing loss (HL), and cochlear implants (CIs)...
July 24, 2017: American Journal of Audiology
https://www.readbyqxmd.com/read/28738117/shining-laser-light-on-traumatic-brain-injury-blood-biomarkers
#10
Lee E Goldstein, Ann C McKee
No abstract text is available yet for this article.
July 24, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/28738048/scalp-cooling-the-prevention-of-chemotherapy-induced-alopecia%C3%A2
#11
Anne Katz
Hair loss (alopecia) from chemotherapy is one of the most feared side effects of many patients, particularly women. Many patients and their healthcare providers believe that cryotherapy can help prevent or mitigate these changes. Scalp cooling has been used for more than 30 years to prevent alopecia caused by chemotherapy, particularly taxanes and anthracyclines. This article presents an overview of the evidence for this strategy, as well as its impact on nursing care provision.
August 1, 2017: Clinical Journal of Oncology Nursing
https://www.readbyqxmd.com/read/28737960/optimization-and-interpretation-of-serial-quantiferon-testing-to-measure-acquisition-of-m-tuberculosis-infection
#12
Elisa Nemes, Virginie Rozot, Hennie Geldenhuys, Nicole Bilek, Simbarashe Mabwe, Deborah Abrahams, Lebohang Makhethe, Mzwandile Erasmus, Alana Keyser, Asma Toefy, Yolundi Cloete, Frances Ratangee, Thomas Blauenfeldt, Morten Ruhwald, Gerhard Walzl, Bronwyn Smith, Andre G Loxton, Willem A Hanekom, Jason R Andrews, Maria D Lempicki, Ruth Ellis, Ann M Ginsberg, Mark Hatherill, Thomas J Scriba
RATIONALE: Conversion from a negative to positive QuantiFERON-TB test is indicative of Mycobacterium tuberculosis (M.tb) infection, which predisposes to tuberculosis disease. Interpretation of serial tests is confounded by immunological and technical variability. OBJECTIVES: To improve consistency of serial QuantiFERON-TB testing algorithms and provide a data-driven definition of conversion. METHODS: Sources of QuantiFERON-TB variability were assessed and optimal procedures identified...
July 24, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28737930/self-collapse-lithography
#13
Chuanzhen Zhao, Xiaobin Xu, Qing Yang, Tianxing Man, Steven Jonas, Jeffrey J Schwartz, Anne M Andrews, Paul S Weiss
We report a facile, high-throughput soft lithography process that utilizes nanoscale channels formed naturally at the edges of microscale relief features on soft, elastomeric stamps. Upon contact with self-assembled monolayer (SAM) functionalized substrates, the roof of the stamp collapses, resulting in the selective removal of SAM molecules via a chemical lift-off process. With this technique, which we call self-collapse lithography (SCL), sub-30-nm patterns were achieved readily using masters with microscale features prepared by conventional photolithography...
July 24, 2017: Nano Letters
https://www.readbyqxmd.com/read/28737922/disentangling-the-complex-vibrational-spectrum-of-the-protonated-water-trimer-h-h2o-3-with-two-color-ir-ir-photodissociation-of-the-bare-ion-and-anharmonic-vscf-vci-theory
#14
Chinh H Duong, Olga Gorlova, Nan Yang, Patrick J Kelleher, Qi Yu, Anne B McCoy, Joel M Bowman, Mark A Johnson
Vibrational spectroscopy of the protonated water trimer provides a stringent constraint on the details of the potential energy surface (PES) and vibrational dynamics governing excess proton motion far from equilibrium. Here we report the linear spectrum of the cold, bare H(+)(H2O)3 ion using a two-color, IR-IR photofragmentation technique and follow the evolution of the bands with increasing temperature. The key low energy features are insensitive to both D2-tagging and internal energy. The D2-tagged D(+)(D2O)3 spectrum is reported for the first time, and the isotope dependence of the band pattern is surprisingly complex...
July 24, 2017: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/28737888/discovery-of-novel-proline-based-neuropeptide-ff-receptor-antagonists
#15
Thuy Nguyen, Ann M Decker, Tiffany L Langston, Kelly M Mathews, Justin N Siemian, Jun-Xu Li, Danni L Harris, Scott P Runyon, Yanan Zhang
The neuropeptide FF (NPFF) system has been implicated in a number of physiological processes including modulating the pharmacological activity of opioid analgesics and several other classes of drugs of abuse. In this study, we report the discovery of a novel proline scaffold with antagonistic activity at the NPFF receptors through a high throughput screening campaign using a functional calcium mobilization assay. Focused structure-activity relationship studies on the initial hit 1 have resulted in several analogs with calcium mobilization potencies in the submicromolar range and modest selectivity for the NPFF1 receptor...
July 24, 2017: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/28737722/induction-of-a-regulatory-phenotype-in-cd3-cd4-hla-dr-t-cells-after-allogeneic-mixed-lymphocyte-culture-indications-of-both-contact-dependent-and-independent-activation
#16
Anne Louise Schacht Revenfeld, Rikke Bæk, Malene Møller Jørgensen, Kim Varming, Allan Stensballe
Although the observation of major histocompatibility complex II (MHCII) receptors on T cells is longstanding, the explanation for this occurrence remains enigmatic. Reports of an inducible, endogenous expression exist, as do studies demonstrating a protein acquisition from other cells by mechanisms including vesicle transfer. Irrespective of origin, the presence of the human MHCII isotype, human leukocyte antigen DR (HLA-DR), potentially identifies a regulatory T cell population. Using an allogeneic mixed lymphocyte culture (MLC) to induce an antigen-specific immune response, the role of antigen-presenting cells (APCs) for the presence of HLA-DR on cluster of differentiation 3(CD3)+ CD4+ T cells was evaluated...
July 24, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28737680/mapping-quantitative-trait-loci-qtl-for-resistance-to-late-blight-in-tomato
#17
Dilip R Panthee, Ann Piotrowski, Ragy Ibrahem
Late blight caused by Phytophthora infestans (Montagne, Bary) is a devastating disease of tomato worldwide. There are three known major genes, Ph-1, Ph-2, and Ph-3, conferring resistance to late blight. In addition to these three genes, it is also believed that there are additional factors or quantitative trait loci (QTL) conferring resistance to late blight. Precise molecular mapping of all those major genes and potential QTL is important in the development of suitable molecular markers and hence, marker-assisted selection (MAS)...
July 22, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28737649/race-age-and-geography-impact-hepatitis-c-genotype-distribution-in-the-united-states
#18
Stuart C Gordon, Sheri Trudeau, Jia Li, Yueren Zhou, Loralee B Rupp, Scott D Holmberg, Anne C Moorman, Philip R Spradling, Eyasu Teshale, Joseph A Boscarino, Yihe G Daida, Mark A Schmidt, Mei Lu
GOALS: To determine the impact of geography and patient characteristics on hepatitis C virus (HCV) genotype and subtype distribution in a large sample of patients under routine clinical care BACKGROUND:: HCV genotype impacts disease course and response to treatment. Although several studies have reported genotype distribution within specific US populations, there are no comprehensive descriptions in large, geographically diverse cohorts. STUDY: Using data from the Chronic Hepatitis Cohort Study, we present the distribution of HCV genotypes (GT) and subtypes (ST) among a racially diverse cohort of over 8000 HCV-infected patients from four large US health systems...
July 21, 2017: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/28737571/breast-feeding-and-infant-hospitalization-for-infections-large-cohort-and-sibling-analysis
#19
Ketil Størdal, Karen M Lundeby, Anne L Brantsæter, Margaretha Haugen, Britt Nakstad, Nicolai A Lund-Blix, Lars C Stene
OBJECTIVES: Breast-feeding may protect against infections, but its optimal duration remains controversial. We aimed to study the association of the duration of full and any breast-feeding with infections the first 18 months of life. METHODS: The Norwegian Mother and Child study (MoBa) is a prospective birth cohort which recruited expecting mothers giving birth from 2000 to 2009. We analyzed data from the full cohort (n = 70,511) and sibling sets (n = 21,220) with parental report of breast-feeding and infections...
August 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28737486/-no-daddy-a-kind-of-daddy-words-used-by-donor-conceived-children-and-aspiring-parents-to-refer-to-the-sperm-donor
#20
Veerle Provoost, Jodie Bernaerdt, Hanna Van Parys, Ann Buysse, Petra De Sutter, Guido Pennings
Research has shown that the recipients of donor sperm can experience difficulties finding appropriate language to refer to the donor. Based on two qualitative analysis techniques, namely word count and empirical discourse analysis, we studied the words used to refer to the donor in heterosexual and lesbian (aspiring) parents and in donor conceived children. Findings show that the words used in these households are highly diverse and have at least four different interlinked functions: (1) to position the donor in relation to the nuclear family; (2) to safeguard the role of the social parent; (3) to clarify family structure; and (4) to present a positive picture of the donor...
July 24, 2017: Culture, Health & Sexuality
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